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1 | status as of October 2022 | developer | manufacturer | manufacturer country | vaccine | platform | announcement url | date tech transfer deal was announced | quarter announced | time between agreement annoucement date and estimated or actual manufacture start date_1 | time between agreement annoucement date and estimated or actual manufacture start date_2 | time between agreement annoucement date and estimated or actual manufacture start date_3 | details about the estimated or actual manufacturing start date | only involves fill-and-finish or other substances aside from active ingredients | details about the manufacturing steps or activities to be carried out | stage of development when tech transfer deal was announced | months between the phase 3 trial and the tech transfer deal date | date when earliest phase 3 trial started | months between approval and the tech transfer deal date | date of first known authorization | place of first known authorization | date |
2 | authorized | Pfizer/BioNTech | Polymun | Austria | BNT162b2 | mRNA | https://investors.biontech.de/news-releases/news-release-details/biontech-reports-rapid-progress-covid-19-vaccine-program-address/ | March 16, 2020 | 2020 Q1 | phase 1 | -4.4 | July 27, 2020 | -8.6 | December 2, 2020 | United Kingdom | 2020-3 | ||||||
3 | phase 3 | Inovio | Ology Bioservices | United States | INO-4800 | DNA-based | https://www.prnewswire.com/news-releases/ology-bioservices-inovio-partner-to-manufacture-covid-19-dna-vaccine-with-11-9-million-department-of-defense-grant-301028626.html | March 24, 2020 | 2020 Q1 | - | - | - | entire process, active ingredient, others | "Ology Bioservices will work with Inovio Pharmaceuticals to manufacture Inovio's DNA vaccine (INO-4800) for prevention of infection with the COVID-19 virus" | pre-clinical | -8.0 | November 24, 2020 | 2020-3 | ||||
4 | authorized | Johnson & Johnson | Emergent BioSolutions | United States | Ad26.COV2-S | viral vector | https://www.jnj.com/johnson-johnson-announces-collaboration-to-expand-manufacturing-capabilities-for-its-covid-19-vaccine-candidate-in-support-of-the-companys-goal-to-supply-more-than-one-billion-vaccine-doses-globally | April 23, 2020 | 2020 Q2 | nine months | 9-12 | 7-9 | according to Emergent, when the announcement was made delivery was set to start at the begining of 2021. However, it is likely that they held of from starting delivery earlier to wait for the regulatory authorization of the vaccine, which was still several months away when the tech transfer deal was signed: https://investors.emergentbiosolutions.com/news-releases/news-release-details/emergent-biosolutions-signs-five-year-agreement-large-scale-drug | entire process, active ingredient, others | "Emergent will provide drug substance manufacturing services with its molecule-to-market CDMO offering, beginning in 2020, and will also reserve operations capacity to potentially support commercial manufacturing of Johnson & Johnson’s COVID-19 vaccine candidate leveraging Janssen’s proven AdVac® and PER.C6® technologies beginning in 2021" | pre-clinical | -3.6 | August 10, 2020 | -10.2 | February 27, 2021 | United States | 2020-4 |
5 | authorized | Johnson & Johnson | Catalent | United States | Ad26.COV2-S | viral vector | https://www.catalent.com/catalent-news/catalent-signs-agreement-with-johnson-johnson-for-lead-covid-19-vaccine-candidate/ | April 29, 2020 | 2020 Q2 | eight months | 7-8 | 7-9 | "Catalent plans to hire approximately 300 additional employees at the site for this program starting in July 2020 to meet operational readiness and 24×7 manufacturing schedules by January 2021." | entire process, active ingredient, others | "Catalent’s Biologics business unit will accelerate availability of manufacturing capacity and prepare for large-scale commercial manufacturing at its facility in Bloomington, Indiana of Johnson & Johnson’s lead vaccine candidate for COVID-19" | pre-clinical | -3.4 | August 10, 2020 | -10.0 | February 27, 2021 | United States | 2020-4 |
6 | phase 3 | Inovio | Richter-Helm BioLogics GmbH & Co | Germany | INO-4800 | DNA-based | https://ir.inovio.com/news-releases/news-releases-details/2020/INOVIO-Expands-Manufacturing-of-COVID-19-DNA-Vaccine-INO-4800-With-New-Funding-from-CEPI/default.aspx | April 30, 2020 | 2020 Q2 | - | - | - | entire process, active ingredient, others | "large-scale manufacturing of INOVIO's investigational DNA vaccine INO-4800" | phase 1 | -6.8 | November 24, 2020 | 2020-4 | ||||
7 | authorized | Moderna | Lonza | Switzerland | mRNA-1273 | mRNA | https://www7.lonza.com/~/media/Files/japan/News/200501_Press_Release__Moderna_Lonza_COVID_FINAL.pdf | May 1, 2020 | 2020 Q2 | one month | 1-2 | 1-3 | "Technology transfer is expected to begin in June 2020, and the companies intend to manufacture the first batches of mRNA-1273 at Lonza U.S. in July 2020" | entire process, active ingredient, others | "Under the terms of the agreement, the companiesplan toestablish manufacturing suites at Lonza’s facilities in the United States and Switzerland for the manufacture of mRNA-1273 at both sites.Technology transfer is expected to begin in June2020, and the companies intend to manufacture the first batches of mRNA-1273 at Lonza U.S. in July 2020." | phase 1 | -2.9 | July 27, 2020 | -7.6 | December 18, 2020 | United States | 2020-5 |
8 | phase 2 | Arcturus Therapeutics | Catalent | United States | ARCT-021, LUNAR-COV19 | RNA-based | https://www.catalent.com/catalent-news/arcturus-therapeutics-and-catalent-announce-partnership-to-manufacture-mrna-based-covid-19-vaccine/ | May 4, 2020 | 2020 Q2 | two months | 1-2 | 1-3 | "Technology transfer will be completed this month and manufacture of the first cGMP batches of LUNAR-COV19 mRNA are expected to be completed by June 2020." https://www.catalent.com/catalent-news/arcturus-therapeutics-and-catalent-announce-partnership-to-manufacture-mrna-based-covid-19-vaccine/ | entire process, active ingredient, others | "The manufacture of LUNAR-COV19 at Catalent’s state-of-the-art drug substance biomanufacturing facility in Madison, Wisconsin will support human clinical studies and, if successful, commercialization of the vaccine. The COVID-19 vaccine program will take advantage of the facility’s flex-suite, a cGMP manufacturing suite that can produce batches at multiple scales and support Arcturus’ proprietary mRNA manufacturing process." | pre-clinical | 2020-5 | |||||
9 | authorized | Johnson & Johnson | Vibalogics | Germany | Ad26.COV2-S | viral vector | https://vibalogics.com/vibalogics-announces-collaboration-with-janssens-to-provide-additional-clinical-trial-material-for-covid-19-vaccine-candidate/ | May 14, 2020 | 2020 Q2 | - | - | - | entire process, active ingredient, others | "From its GMP accredited facility in Cuxhaven, Germany, the company is contracted to manufacture multiple batches, which will result in many thousands of doses of an investigational COVID-19 vaccine candidate." | pre-clinical | -2.9 | August 10, 2020 | -9.5 | February 27, 2021 | United States | 2020-5 | |
10 | authorized | Moderna | CordenPharma | France | mRNA-1273 | mRNA | https://www.cordenpharma.com/CordenPharma_and_Moderna_Extend_Lipid_Supply_Agreement_for_Moderna_Vaccine_mRNA-1273_Against_Novel_Coronavirus_SARS-CoV-2 | May 28, 2020 | 2020 Q2 | - | - | - | lipid supply agreement | entire process, active ingredient, others | "manufacture large-scale volumes of Moderna’s lipid excipients to be used in the manufacture of Moderna’s vaccine candidate (mRNA-1273) against the novel coronavirus (SARS-CoV-2)." | phase 2 | -2.0 | July 27, 2020 | -6.7 | December 18, 2020 | United States | 2020-5 |
11 | authorized | AstraZeneca/Oxford | Oxford Biomedica | United Kingdom | AZD1222 | viral vector | https://www.oxb.com/news-media/press-release/oxford-biomedica-signs-clinical-commercial-supply-agreement-astrazeneca | May 28, 2020 | 2020 Q2 | four months | 3-4 | 4-6 | According to a September 17, 2020 interview, Oxford Biomedica was already producing: https://www.youtube.com/watch?v=fc4eK09tnIU | entire process, active ingredient, others | "AstraZeneca will have access to Oxford Biomedica’s new 7,800 m2 commercial manufacturing centre Oxbox, located in Oxford, UK. In April 2020 Oxford Biomedica announced that it had joined a consortium including the Jenner Institute in relation to the potential for large scale manufacture of AZD1222" | phase 2/3 | 0.1 | May 26, 2020 | -7.1 | December 30, 2020 | United Kingdom, Argentina | 2020-5 |
12 | authorized | Novavax | AGC Biologics | Denmark | NVX-CoV2373 | protein-based | http://www.agcbio.com/news/novavax-selects-agc-biologics-to-manufacture-matrix-m-adjuvant-for-novel-covid-19-vaccine | June 3, 2020 | 2020 Q2 | eight months | 7-8 | 7-9 | Novavax said that this agreement could help them deliver doses "in 2020": https://www.sec.gov/ix?doc=/Archives/edgar/data/1000694/000110465920092782/nvax-20200630x10q.htm | entire process, active ingredient, others | "AGC Biologics will manufacture Matrix-M™, the adjuvant component of the vaccine, in order to enhance the immune response and stimulate high levels of neutralizing antibodies." | phase 1/2 | -4.3 | October 12, 2020 | -18.6 | December 20, 2021 | EMA | 2020-6 |
13 | authorized | AstraZeneca/Oxford | Serum Institute | India | AZD1222 | viral vector | https://www.astrazeneca.com/media-centre/articles/2020/astrazeneca-takes-next-steps-towards-broad-and-equitable-access-to-oxford-universitys-potential-covid-19-vaccine.html | June 4, 2020 | 2020 Q2 | six months | 5-6 | 4-6 | On November 12, 2020. SII said it had already produced 40 million doses of the AZ vaccine | entire process, active ingredient, others | "supply one billion doses for low-and-middle-income countries, with a commitment to provide 400 million before the end of 2020." | phase 2/3 | 0.3 | May 26, 2020 | -6.9 | December 30, 2020 | United Kingdom, Argentina | 2020-6 |
14 | authorized | Novavax | PolyPeptide Group | Switzerland | NVX-CoV2373 | protein-based | https://www.polypeptide.com/press-release-polypeptide-group-selected-by-novavax-to-manufacture-critical-intermediates-of-matrix-m-adjuvant-for-its-covid-19-vaccine/ | June 4, 2020 | 2020 Q2 | - | - | - | "In June 2020, we entered into contract manufacturing arrangements with AGC Biologics and the Polypeptide Group to provide contract development and manufacturing services, supplying us with large-scale production of Matrix-M. These arrangements are expected to allow us to significantly increase our capacity to deliver doses of NVX-CoV2373 in 2020 and 2021." https://www.sec.gov/ix?doc=/Archives/edgar/data/1000694/000110465920092782/nvax-20200630x10q.htm | entire process, active ingredient, others | "PolyPeptide Group will produce two key intermediates used in the production of Matrix-M™, the adjuvant component of the vaccine, which is being used to enhance the vaccine’s immune response and stimulate high levels of neutralizing antibodies." | phase 1/2 | -4.3 | October 12, 2020 | -18.5 | December 20, 2021 | EMA | 2020-6 |
15 | authorized | Sinovac | Butantan Institute | Brazil | CoronaVac | inactivated virus | https://www.biospace.com/article/releases/sinovac-and-butantan-join-efforts-to-advance-the-clinical-development-of-an-inactivated-vaccine-for-covid-19-to-phase-iii/ | June 11, 2020 | 2020 Q2 | six months | 5-6 | 4-6 | "The Butantan Institute, a Brazilian biological research center, has started manufacturing CoronaVac, a vaccine against the novel coronavirus (COVID-19), still in its testing phase. Production will be conducted in partnership with Chinese pharmaceutical company Sinovac." https://agenciabrasil.ebc.com.br/en/saude/noticia/2020-12/brazilian-institute-start-production-vaccine-coronavac | fill-and-finish | fill-and-finish | phase 1/2 | -0.7 | July 2, 2020 | -7.0 | January 11, 2021 | Indonesia | 2020-6 |
16 | authorized | AstraZeneca/Oxford | Emergent BioSolutions | United States | AZD1222 | viral vector | https://investors.emergentbiosolutions.com/news-releases/news-release-details/emergent-biosolutions-signs-agreement-be-us-manufacturing-0?field_nir_news_date_value%5Bmin%5D= | June 11, 2020 | 2020 Q2 | seven months | 7-8 | 7-9 | Manufacturing started as of February 2021, per Emergent BioSolutions CEO Bob Kramer interview | entire process, active ingredient, others | "Emergent will provide development services, technology transfer, analytical testing, drug substance process and performance qualification and will reserve certain large-scale manufacturing capacity through 2020." | phase 2/3 | 0.5 | May 26, 2020 | -6.6 | December 30, 2020 | United Kingdom, Argentina | 2020-6 |
17 | authorized | AstraZeneca/Oxford | Novasep (plant acquired by Thermo Fisher) | France | AZD1222 | viral vector | https://web.archive.org/web/20201127123206/https://www.novasep.com/home/about-novasep/media-events/press-release/coronavirus-novasep-partners-with-astrazeneca-to-produce-covid-19-oxford-vaccine-for-europe.html | June 15, 2020 | 2020 Q2 | seven months | 7-8 | 7-9 | althought with shortfalls, Novasep was already producing by January 2021 according to reports: https://www.wsj.com/articles/astrazenecas-covid-19-vaccine-shortfall-threatens-eu-plans-to-boost-inoculations-11611423256 | entire process, active ingredient, others | large-scale production of adenovirus vectors | phase 2/3 | 0.7 | May 26, 2020 | -6.5 | December 30, 2020 | United Kingdom, Argentina | 2020-6 |
18 | authorized | AstraZeneca/Oxford | Catalent | United States | AZD1222 | viral vector | https://www.catalent.com/catalent-news/catalent-signs-agreement-with-astrazeneca-to-manufacture-covid-19-vaccine-candidate/ | June 15, 2020 | 2020 Q2 | three months | 3-4 | 1-3 | "Catalent will prepare the facility to enable round-the-clock manufacturing schedules and supply hundreds of millions of doses of the vaccine candidate from August 2020, and potentially through to March 2022 should the product be approved by regulatory agencies." | entire process, active ingredient, others | "Catalent Biologics will provide vial filling and packaging capacity to AstraZeneca PLC at Catalent’s manufacturing facility in Anagni, Italy, and prepare for large-scale commercial supply of the University of Oxford’s adenovirus vector based COVID-19 vaccine candidate, AZD1222." | phase 2/3 | 0.7 | May 26, 2020 | -6.5 | December 30, 2020 | United Kingdom, Argentina | 2020-6 |
19 | authorized | AstraZeneca/Oxford | Cobra Biologics | United States | AZD1222 | viral vector | https://www.cobrabio.com/news/june-2020/cobra-supply-agreement-astrazeneca-covid19-vaccine | June 16, 2020 | 2020 Q2 | three months | 3-4 | 1-3 | September 2020 | entire process, active ingredient, others | "GMP manufacture of the adenovirus vector-based COVID-19 vaccine candidate AZD1222, previously known as ChAdOx1 n-CoV-19." | phase 2/3 | 0.7 | May 26, 2020 | -6.5 | December 30, 2020 | United Kingdom, Argentina | 2020-6 |
20 | authorized | Moderna | Catalent | United States | mRNA-1273 | mRNA | https://www.catalent.com/catalent-news/moderna-and-catalent-announce-collaboration-for-fill-finish-manufacturing-of-modernas-covid-19-vaccine-candidate/ | June 25, 2020 | 2020 Q2 | three months | 3-4 | 1-3 | "third quarter of 2020" | fill-and-finish | fill-and-finish | phase 2 | -1.1 | July 27, 2020 | -5.8 | December 18, 2020 | United States | 2020-6 |
21 | authorized | AstraZeneca/Oxford | Fiocruz | Brazil | AZD1222 | viral vector | https://portal.fiocruz.br/en/news/covid-19-fiocruz-will-sign-agreement-produce-vaccines-university-oxford#:~:text=The%20Oswaldo%20Cruz%20Foundation%20(Fiocruz,by%20the%20University%20of%20Oxford.&text=Combined%20with%20other%20actions%2C%20it,fight%20the%20Covid%2D19%20pandemic. | June 30, 2020 | 2020 Q2 | six months | 5-6 | 4-6 | December 2020 | entire process, active ingredient, others | "The investment includes not only the vaccine batches, but also the transference of technology, so that the production can be fully internalized and national." | phase 2/3 | 1.1 | May 26, 2020 | -6.0 | December 30, 2020 | United Kingdom, Argentina | 2020-6 |
22 | authorized | Medicago | GlaxoSmithKline | United Kingdom | Covifenz | virus-like particles | https://www.medicago.com/en/media-room/gsk-and-medicago-announce-collaboration-to-develop-a-novel-adjuvanted-covid-19-candidate-vaccine/ | July 7, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | "The companies will use Medicago's plant-based production platform to manufacture the COVID-19 vaccine antigen. This innovative technology uses the leaves of a plant as bioreactors to produce the S-spike protein which self-assemble into VLPs for use in the CoVLP vaccine candidate. It is highly scalable and can support the production of large amounts of vaccine in a significantly shortened timeline." | pre-clinical | -4.4 | November 19, 2020 | -19.6 | February 24, 2022 | Canada | 2020-7 | |
23 | authorized | Moderna | ROVI | Spain | mRNA-1273 | mRNA | https://investors.modernatx.com/news-releases/news-release-details/moderna-and-rovi-announce-collaboration-ous-fill-finish | July 9, 2020 | 2020 Q3 | eight months | 7-8 | 7-9 | "starting in early 2021" | fill-and-finish | "ROVI will provide vial filling and packaging capacity by procuring a new production line and equipment for compounding, filling, automatic visual inspection and labeling to support production of hundreds of millions of doses of the vaccine candidate intended in principle to supply markets outside of the U.S. starting in early 2021." | phase 2 | -0.6 | July 27, 2020 | -5.3 | December 18, 2020 | United States | 2020-7 |
24 | authorized | AstraZeneca/Oxford | R-Pharm | Russian Federation | AZD1222 | viral vector | https://www.reuters.com/article/us-health-coronavirus-cyber-russia-vacci/russias-r-pharm-signs-deal-to-make-uk-developed-covid-19-vaccine-idUSKCN24I1XF | July 17, 2020 | 2020 Q3 | twelve months | 9-12 | 10-12 | R-Pharm said in May 2021 that they were starting exports in June 2021: https://gxpnews.net/en/2021/05/r-pharm-plans-to-release-a-batch-of-astrazeneca-vaccine-in-june/ | entire process, active ingredient, others | "manufacture a COVID-19 vaccine being developed by the British pharmaceuticals giant and Oxford University, it said on Friday." | phase 2/3 | 1.7 | May 26, 2020 | -5.5 | December 30, 2020 | United Kingdom, Argentina | 2020-7 |
25 | authorized | AstraZeneca/Oxford | SK Bioscience | South Korea | AZD1222 | viral vector | https://www.reuters.com/article/us-health-coronavirus-southkorea-astraze/south-koreas-sk-bioscience-in-deal-with-astrazeneca-on-vaccine-idUSKCN24M0ZF | July 21, 2020 | 2020 Q3 | four months | 3-4 | 4-6 | According to news reports, SK Bioscience was already producting by late November 2020: http://www.koreaherald.com/view.php?ud=20201120000748 | entire process, active ingredient, others | "SK Bioscience, a unit of SK Chemicals, said it will start producing undiluted solutions of the vaccine after discussing production plans with AstraZeneca." | phase 2/3 | 1.8 | May 26, 2020 | -5.3 | December 30, 2020 | United Kingdom, Argentina | 2020-7 |
26 | authorized | Novavax | FUJIFILM Diosynth Biotechnologies | Japan | NVX-CoV2373 | protein-based | https://fujifilmdiosynth.com/about-us/news/novavax-and-fujifilm-diosynth-biotechnologies-initiate-large-scale-manufacturing-of-covid-19-vaccine-candidate/ | July 23, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | Two facilities were already producing by January 2021: https://www.fujifilm.com/us/en/news/FUJIFILM-Diosynth-Biotechnologies-Begins-Manufacture-of-COVID-19-Vaccine-in-Texas | entire process, active ingredient, others | "manufacture bulk drug substance for NVX-CoV2373" | phase 1/2 | -2.7 | October 12, 2020 | -16.9 | December 20, 2021 | EMA | 2020-7 |
27 | n/a | Intravacc | Celonic Group | Switzerland | CovOMV | protein-based | https://www.celonic.com/general/intravacc-and-celonic-to-develop-and-produce-a-novel-covid-19-vaccine/ | July 29, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | "Swiss based Celonic Group will construct cell lines producing the S-protein in high quantities and develop a GMP production process." | pre-clinical | 2020-7 | ||||||
28 | authorized | AstraZeneca/Oxford | Wockhardt, CP Pharmaceuticals | United Kingdom | AZD1222 | viral vector | http://www.wockhardt.com/pdfs/press-release-wockhardt-03-08-20.pdf | August 2, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | Wockhardt said in December 2020 that they were prepare to manufacture 100 million doses, pending regulatory approval: https://scrip.pharmaintelligence.informa.com/SC143408/Wockhardt-Preps-To-Deliver-100M-Doses-Of-AZ-Vaccine | fill-and-finish | "Wockhardt, the global pharmaceutical and biotechnology major today announced that it has entered into an agreement with the UK Government to fill finish COVID-19 vaccines." | phase 2/3 | 2.2 | May 26, 2020 | -4.9 | December 30, 2020 | United Kingdom, Argentina | 2020-8 |
29 | authorized | Gamaleya | Generium | Russia | Sputnik V | viral vector | https://tass.com/society/1185199 | August 3, 2020 | 2020 Q3 | three months | 1-2 | 1-3 | Production launched in October: https://www.generium.ru/en/news/generium-launched-the-production-of-sputnik-v-vaccine/ | -0.8 | August 28, 2020 | -4.6 | December 21, 2020 | Belarus | 2020-8 | |||
30 | phase 3 | AnGes | Kaneka Eurogentec | Belgium | AG0302-COVID19 | DNA-based | https://www.kaneka.co.jp/en/topics/news/2020/ennr2008041.html | August 4, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | "Kaneka Eurogentec, an affiliate of Kaneka Corporation, will join the task force led by Takara Bio Inc. that will aim to mass produce a DNA vaccine for the novel coronavirus, which is being developed by AnGes Inc." | phase 1/2 | -3.6 | November 23, 2020 | pending authorization | pending authorization | 2020-8 | ||
31 | authorized | AstraZeneca/Oxford | BioKangtai | China | AZD1222 | viral vector | https://www.fiercepharma.com/manufacturing/astrazeneca-takes-covid-19-vaccine-to-china-biokangtai-deal-for-200m-dose-capacity-by | August 6, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | https://www.reuters.com/article/us-health-coronavirus-kangtai-astrazenec/astrazenecas-china-partner-expects-to-be-able-to-make-400-million-covid-19-vaccine-doses-a-year-idUSKBN2A20VB | 2.4 | May 26, 2020 | -4.8 | December 30, 2020 | United Kingdom, Argentina | 2020-8 | |||
32 | authorized | AstraZeneca/Oxford | Shenzhen Kangtai Biological Products | China | AZD1222 | viral vector | https://www.biospace.com/article/astrazeneca-inks-covid-19-vaccine-deal-with-china-s-shenzhen-kangtai/ | August 6, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | Shenzhen Kangtai said on February 1, 2021, that it had completed building a new facility and started production: https://www.reuters.com/article/health-coronavirus-kangtai-astrazeneca-idCNL1N2K80GN When the deal was announced in August 2020 news reports said that the company had to delivery 100 million doses by December 2020: https://www.bioworld.com/articles/496620-astrazeneca-partners-with-kangtai-bio-to-bring-covid-19-vaccine-to-china | entire process, active ingredient, others | "manufacture AstraZeneca and the University of Oxford’s COVID-19 vaccine in mainland China" | phase 2/3 | 2.4 | May 26, 2020 | -4.8 | December 30, 2020 | United Kingdom, Argentina | 2020-8 |
33 | authorized | Novavax | Serum Institute | India | NVX-CoV2373 | protein-based | https://ir.novavax.com/news-releases/news-release-details/novavax-and-serum-institute-india-announce-development-and | August 6, 2020 | 2020 Q3 | - | - | - | - | entire process, active ingredient, others | "For LMICs and India, Novavax and SIIPL are partnering on clinical development, co-formulation, filling and finishing and commercialization of NVX-CoV2373. SIIPL will be responsible for regulatory submissions and marketing authorizations. Novavax will provide to SIIPL both vaccine antigen and Matrix‑M adjuvant, and Novavax and SIIPL are in discussions to have SIIPL manufacture vaccine antigen in India. Novavax and SIIPL will split the revenue from the sale of product, net of agreed costs." | phase 1/2 | -2.2 | October 12, 2020 | -16.5 | December 20, 2021 | EMA | 2020-8 |
34 | authorized | AstraZeneca/Oxford | Vaccines Manufacturing and Innovation Centre (VMIC) | United Kingdom | AZD1222 | viral vector | https://web.archive.org/web/20201024125213/https://www.oxfordbiomedica.co.uk/news-media/press-release/oxford-biomedica-signs-five-year-collaboration-agreement-vaccines | August 6, 2020 | 2020 Q3 | - | - | - | - | entire process, active ingredient, others | "VMIC will provide manufacturing equipment for Oxford Biomedica to rapidly equip two new GMP manufacturing suites within Oxford Biomedica’s new 7,800 m2 commercial manufacturing centre, Oxbox, located in Oxford, UK" | phase 2/3 | 2.4 | May 26, 2020 | -4.8 | December 30, 2020 | United Kingdom, Argentina | 2020-8 |
35 | authorized | Gamaleya | Tecpar | Brazil | Sputnik V | viral vector | https://rdif.ru/Eng_fullNews/5574/ | August 12, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | "RDIF together with pharmaceutical companies in the state of Parana will organize the production of the “Sputnik V” vaccine and its distribution in Brazil and other Latin American countries." | phase 2 | -0.5 | August 28, 2020 | -4.3 | December 21, 2020 | Belarus | 2020-8 | |
36 | authorized | Johnson & Johnson | Biological E | India | Ad26.COV2-S | viral vector | https://www.biologicale.com/news.html | August 13, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | "for the creation / enhancement of manufacturing capacities for drug substance and drug product for Johnson & Johnson’s COVID-19 vaccine candidate, Ad26.COV2.S. Johnson & Johnson’s COVID-19 vaccine candidate is currently in Phase 1/2a clinical trials." | phase 1/2 | 0.1 | August 10, 2020 | -6.5 | February 27, 2021 | United States | 2020-8 | |
37 | authorized | Baylor | Biological E | India | Corbevax | protein-based | https://www.bcm.edu/news/baylor-and-biological-e-limited-team-up-for-a-global-covid-19-vaccine | August 13, 2020 | 2020 Q3 | entire process, active ingredient, others | pre-clinical | -10.7 | July 6, 2021 | -16.5 | December 28, 2021 | India | 2020-8 | |||||
38 | authorized | Novavax | SK Bioscience | South Korea | NVX-CoV2373 | protein-based | https://ir.novavax.com/news-releases/news-release-details/novavax-and-sk-bioscience-announce-collaboration-novavax-covid | August 13, 2020 | 2020 Q3 | one month | 1-2 | 1-3 | "beginning in August 2020" | entire process, active ingredient, others | "SK bioscience will manufacture the vaccine antigen component for use in the final drug product globally during the pandemic period" | phase 1/2 | -2.0 | October 12, 2020 | -16.2 | December 20, 2021 | EMA | 2020-8 |
39 | authorized | CanSino Biologics | Petrovax | Russia | Ad5-nCoV | viral vector | https://petrovax.com/press_centre/news/2020/1878/ | August 15, 2020 | 2020 Q3 | five months | 5-6 | 4-6 | By December 2021, Petrovax had already launch a phase 3 trial and said that it was ready to manufacture at commercial scale. https://petrovax.com/press_centre/news/2020/2085/ | -0.4 | August 26, 2020 | -5.9 | February 10, 2021 | Mexico | 2020-8 | |||
40 | authorized | AstraZeneca/Oxford | mAbxience | Argentina | AZD1222 | viral vector | https://www.mabxience.com/mabxience-enters-into-an-agreement-with-astrazeneca-to-produce-covid-19-vaccine/ | August 17, 2020 | 2020 Q3 | four months | 3-4 | 4-6 | Hugo Sigman announced on November 13, 2020, that production would start in two weeks. | entire process, active ingredient, others | "produce the active ingredient, which will subsequently be sent to Mexico to complete the production and filling process." | phase 2/3 | 2.7 | May 26, 2020 | -4.4 | December 30, 2020 | United Kingdom, Argentina | 2020-8 |
41 | authorized | AstraZeneca/Oxford | Laboratorio Liomont | Mexico | AZD1222 | viral vector | https://elpais.com/mexico/sociedad/2021-05-10/mexico-distribuira-la-vacuna-latinoamericana-a-finales-de-mayo-despues-de-semanas-de-atraso.html | August 17, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | "El plan original, confirmado por Ebrard, suponía que las vacunas comenzarían a entregarse en abril" | fill-and-finish | phase 2/3 | 2.7 | May 26, 2020 | -4.4 | December 30, 2020 | United Kingdom, Argentina | 2020-8 | |
42 | authorized | Sinovac | Bio Farma | Indonesia | CoronaVac | inactivated virus | https://www.biospace.com/article/releases/sinovac-signs-agreement-with-bio-farma-indonesia-for-covid-19-vaccine-cooperation/ | August 25, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | "As of Thursday, January 21, there have been 4 million doses that have been produced. The status of these products is in the process of quality control, which will be sent to the POM to get a lot release so that it can be distributed, and it is estimated that until February. In the coming 2021, 4 million doses of vaccine will be ready, "said Director of Bio Farma, Honesti Basyir in an official statement received in Jakarta, reported by Antara, Saturday, January 23." https://voi.id/en/news/28470/bio-farma-is-ready-to-distribute-4-million-doses-of-covid-19-vaccine-in-february | fill-and-finish | Sinovac is committed to supply Bio Farma bulk vaccine to enable the latter to produce at least 40 million doses of CoronaVac in Indonesia before March 2021 | phase 3 | 1.8 | July 2, 2020 | -4.6 | January 11, 2021 | Indonesia | 2020-8 |
43 | authorized | Sinopharm | BCHT Bioteknologi | Indonesia | BBIBP-CorV | inactivated virus | https://www.cnbcindonesia.com/news/20200812184641-4-179386/jokowi-siapkan-rp-50-t-buat-vaksin-covid-19 | August 25, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | - | phase 3 | 0.4 | August 12, 2020 | -3.5 | December 9, 2020 | United Arab Emirates | 2020-8 | |
44 | authorized | Sinopharm | Bio Farma | Indonesia | BBIBP-CorV | inactivated virus | https://asia.nikkei.com/Spotlight/Coronavirus/Indonesia-teams-with-China-s-Sinovac-for-COVID-vaccine | August 25, 2020 | 2020 Q3 | - | - | - | fill-and-finish | fill-and-finish | phase 3 | 0.4 | August 12, 2020 | -3.5 | December 9, 2020 | United Arab Emirates | 2020-8 | |
45 | authorized | AstraZeneca/Oxford | Albany Molecular Research | United States | AZD1222 | viral vector | https://www.amriglobal.com/blog/news-and-events/news/amri-selected-to-support-astrazeneca-in-delivery-of-covid-19-vaccine/ | September 3, 2020 | 2020 Q3 | four months | 3-4 | 4-6 | Albany Molecular Research said in January 2021 that their Albuquerque location was "currently supporting COVID-19 vaccine production." Albuquerque is the location were Albany agreed to do fill-and-finish for AZ. https://www.amriglobal.com/blog/news-and-events/news/amri-included-in-barda-cdmo-network-in-support-of-covid-19-pandemic-response-in-the-u-s/ | fill-and-finish | fill-and-finish | phase 2/3 | 3.3 | May 26, 2020 | -3.9 | December 30, 2020 | United Kingdom, Argentina | 2020-9 |
46 | authorized | AstraZeneca/Oxford | CSL Behring Ltd. | Australia | AZD1222 | viral vector | https://www.csl.com/news/2020/20200907-csl-to-manufacture-and-supply-uq-and-ou-vaccine-candidates-for-australia | September 7, 2020 | 2020 Q3 | three months | 3-4 | 1-3 | CSL said that it will start manufacturing on November 9, 2020: https://www.csl.com/news/2020/20201108-csl-commences-manufacturing-of-university-of-oxford-astrazeneca-vaccine-candidate It is unclear when this deal was first announced, but it appears to be either July or August. | entire process, active ingredient, others | "manufacture approximately 30 million doses of the AZD1222 vaccine candidate, with first doses planned for release to Australia early next year" | phase 2/3 | 3.4 | May 26, 2020 | -3.7 | December 30, 2020 | United Kingdom, Argentina | 2020-9 |
47 | abandoned | University of Queensland | CSL Behring Ltd. | Australia | V451 | protein-based | https://www.csl.com/news/2020/20200907-csl-to-manufacture-and-supply-uq-and-ou-vaccine-candidates-for-australia | September 7, 2020 | 2020 Q3 | eight months | 7-8 | 7-9 | "mid-2021" | entire process, active ingredient, others | "supply of 51 million doses" | phase 1 | abandoned | abandoned | 2020-9 | |||
48 | phase 3 | Inovio | Thermo Fisher | United States | INO-4800 | DNA-based | http://ir.inovio.com/news-releases/news-releases-details/2020/INOVIO-Adds-Thermo-Fisher-Scientific-To-Global-Manufacturing-Consortium/default.aspx | September 8, 2020 | 2020 Q3 | - | - | - | entire process, active ingredient, others | "manufacture INO-4800 drug substance as well as perform fill and finish of INO-4800 drug product at its commercial facilities in the US" | phase 2 | -2.5 | November 24, 2020 | 2020-9 | ||||
49 | authorized | Pfizer/BioNTech | Dermapharm | Germany | BNT162b2 | mRNA | https://www.pharmiweb.com/press-release/2020-09-10/dermapharm-holding-se-signs-cooperation-and-delivery-agreement-with-biontech-se-on-the-production | September 10, 2020 | 2020 Q3 | three months | 3-4 | 1-3 | "Dermapharm Holding SE ("Dermapharm"), a leading manufacturer of patent-free branded pharmaceuticals for selected therapeutic areas, will support the vaccine developer BioNTech SE in part of the vaccine production of BNT162b2 starting in the fourth quarter of 2020. Once approval for the vaccine has been received, the Dermapharm Group will make production capacities available and expand them at its German site in order to offer BioNTech the greatest possible support." https://www.pharmiweb.com/press-release/2020-09-10/dermapharm-holding-se-signs-cooperation-and-delivery-agreement-with-biontech-se-on-the-production | fill-and-finish | "The active ingredient, the mRNA, is manufactured in Germany by BioNTech." | phase 3 | 1.5 | July 27, 2020 | -2.7 | December 2, 2020 | United Kingdom | 2020-9 |
50 | authorized | Pfizer/BioNTech | Siegfried | Switzerland | BNT162b2 | mRNA | https://www.siegfried.ch/pages/mod/getMedById.cfm?medId=14212 | September 14, 2020 | 2020 Q3 | - | - | - | fill-and-finish | "large-scale filling and packaging of commercial quantities of BNT162b2" | phase 3 | 1.6 | July 27, 2020 | -2.6 | December 2, 2020 | United Kingdom | 2020-9 | |
51 | authorized | Novavax | Biofabri | Spain | NVX-CoV2373 | protein-based | https://ir.novavax.com/news-releases/news-release-details/novavax-announces-covid-19-vaccine-manufacturing-agreement-serum | September 15, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | Biofabri CEO said in March 2021 that they were already producing 1,000 liters of the Novavax antigent per week: https://www.farodevigo.es/sociedad/2021/03/13/fabricamos-lotes-semanales-1-000-41671474.html | entire process, active ingredient, others | "antigen component of NVX-CoV2373" | phase 1/2 | -0.9 | October 12, 2020 | -15.1 | December 20, 2021 | EMA | 2020-9 |
52 | authorized | Gamaleya | Dr Reddy's | India | Sputnik V | viral vector | https://www.drreddys.com/media/904781/sputnikv-india_dr-reddys.pdf | September 16, 2020 | 2020 Q3 | four months | 3-4 | 4-6 | "Deliveries could potentially begin in late 2020 subject to completion of successful trials and registration of the vaccine by regulatory authorities in India." https://www.drreddys.com/media/904781/sputnikv-india_dr-reddys.pdf | entire process, active ingredient, others | - | phase 1/2 | 0.6 | August 28, 2020 | -3.2 | December 21, 2020 | Belarus | 2020-9 |
53 | authorized | Gamaleya | Pharco Pharmaceuticals | Egypt | Sputnik V | viral vector | https://www.prnewswire.com/ae/news-releases/rdif-and-pharco-agree-to-supply-25-million-doses-of-sputnik-v-vaccine-to-egypt-823006786.html | September 20, 2020 | 2020 Q3 | seven months | 7-8 | 7-9 | "Local reports last year say that Pharco will start manufacturing the Russian vaccine starting April as per a memorandum of understanding between Biogenix Corporation, an affiliate of Pharco Pharmaceutical Group, and the RIF." https://english.ahram.org.eg/NewsContent/1/64/404860/Egypt/Politics-/Egypts-coronavirus-vaccination-campaign-A-timeline.aspx | fill-and-finish | fill-and-finish | phase 1/2 | 0.8 | August 28, 2020 | -3.0 | December 21, 2020 | Belarus | 2020-9 |
54 | authorized | CanSino Biologics | Solbio | Malaysia | Ad5-nCoV | viral vector | https://www.businesstoday.com.my/2020/09/29/solbio-forges-partnership-with-cansino-biologics-to-distribute-coronavirus-vaccine-in-malaysia/ | September 23, 2020 | 2020 Q3 | six months | 5-6 | 4-6 | Malaysia started receiving filled and finished vaccines in April 2021. "He said the procurement of the vaccine is being made in two categories, namely finished product of 500,000 doses, and the rest delivery in bulk to be filled and packaged by local company Solutions Biologics Sdn Bhd (SolBio)." https://www.thestar.com.my/news/nation/2021/04/01/malaysia-will-start-receiving-cansino-covid-19-vaccine-from-this-month | fill-and-finish | "SOLBIO will establish a “state-of-the-art” fill and finish facility while CanSinoBio will provide the technology transfer and relevant technical know-how for the operation of the facility." | phase 3 | 0.9 | August 26, 2020 | -4.6 | February 10, 2021 | Mexico | 2020-9 |
55 | authorized | Gamaleya | BIOCAD | Russia | Sputnik V | viral vector | https://sputniknews.com/20200924/russian-biotech-company-biocad-set-to-produce-covid-19-vaccine-sputnik-v-1080556918.html | September 24, 2020 | 2020 Q3 | four months | 3-4 | 4-6 | Althought with challenges, they were scaling up by December 2020. https://www.wsj.com/articles/russia-struggles-to-make-promised-doses-of-its-sputnik-v-vaccine-11607601609 and producing by April 2021: https://tass.com/society/1273533 | 0.9 | August 28, 2020 | -2.9 | December 21, 2020 | Belarus | 2020-9 | |||
56 | authorized | Novavax | Endo International | United States | NVX-CoV2373 | protein-based | https://investor.endo.com/news-releases/news-release-details/endo-announces-fill-finish-manufacturing-and-services-agreement | September 25, 2020 | 2020 Q3 | one month | 1-2 | 1-3 | "Under the terms of the agreement, Par Sterile's Rochester facility has begun production of NVX-CoV2373 final drug product, with initial batches to be used in Novavax' pivotal Phase 3 clinical trial in the United States." | fill-and-finish | fill and finish | phase 3 | -0.6 | October 12, 2020 | -14.8 | December 20, 2021 | EMA | 2020-9 |
57 | authorized | Johnson & Johnson | Grand River Aseptic Manufacturing (GRAM) | United States | Ad26.COV2-S | viral vector | https://www.grandriverasepticmfg.com/news/gram-partners-with-johnson-johnson-on-manufacturing-in-fight-against-covid-19/ | September 25, 2020 | 2020 Q3 | three months | 3-4 | 1-3 | When the J&J vaccine was authorized there were news reports suggesting that GRAM had been manufacturing since the Fall 2020: https://www.youtube.com/watch?v=A8zLMxwPJNg In late February 2020 GRAM said that they had been manufacturing "for a few months": https://www.youtube.com/watch?v=L5CFaowp0Qo | fill-and-finish | "technical transfer and fill and finish manufacture" | phase 3 | 1.5 | August 10, 2020 | -5.1 | February 27, 2021 | United States | 2020-9 |
58 | authorized | Gamaleya | Belmedpreparaty | Belarus | Sputnik V | viral vector | https://tass.com/world/1287621 | October 1, 2020 | 2020 Q4 | - | - | - | In February 2021. "The first batch of the Gam-COVID-Vak (Sputnik V) vaccine developed by the Gamaleya National Center has been produced for validation at Belmedpreparaty production facilities, utilizing technology transferred by the Russian company Generium. Upon obtaining the results of the stability study for the first batch of Sputnik V, preparations will begin for mass production. RDIF and its partners are also working on testing the full-cycle technology used for Sputnik V production at facilities in the Republic of Belarus. Production of Sputnik V at Belmedpreparaty sites will meet 100% of vaccine requirements in Belarus in order to protect its citizens against COVID-19." https://rdif.ru/Eng_fullNews/6473/ | entire process, active ingredient, others | "The three-week laboratory trials of next series of Sputnik V vaccine, which were produced by the Belmedpreparaty enterprise, have been completed at the Gamaleya National Research Center for Epidemiology and Microbiology. The vaccine has passed quality control," the statement says. | phase 3 | 1.1 | August 28, 2020 | -2.7 | December 21, 2020 | Belarus | 2020-10 |
59 | phase 1 | VLP Therapeutics | Fujifilm | Japan | VLP Therapeutics' | RNA-based | https://www.fujifilm.com/mm/en/news/hq/5493 | October 1, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "Fujifilm will utilize its manufacturing facilities and infrastructure for lipid nanoparticle to handle operations relating to VLP Therapeutics’ COVID-19 vaccine formulations, from process development to manufacturing for clinical trials." | pre-clinical | 2020-10 | ||||||
60 | phase 2 | Arcturus Therapeutics | Recipharm | France | ARCT-021, LUNAR-COV19 | RNA-based | https://www.recipharm.com/press/recipharm-signs-agreement-arcturus-therapeutics-support-manufacture-lunar%C2%AE-cov19-arct-021 | October 6, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "Arcturus has secured manufacturing slots with Recipharm to support the manufacture of ARCT-021, Arcturus’ COVID-19 vaccine candidate that is in an ongoing phase 1/2 clinical trial." | phase 1/2 | 2020-10 | ||||||
61 | authorized | Pfizer/BioNTech | Rentschler Biopharma | Germany | BNT162b2 | mRNA | https://www.rentschler-biopharma.com/news/press-releases-and-announcements/detail/view/joining-forces-against-sars-cov-2/ | October 7, 2020 | 2020 Q4 | two months | 1-2 | 1-3 | According to news reports, production started by November 20, 2020: https://www.swr.de/swraktuell/baden-wuerttemberg/friedrichshafen/rentschler-laupheim-beginnt-produktion-fuer-corona-impfstoff-100.html | entire process, active ingredient, others | "key aspects of cGMP (current good manufacturing practice) drug substance manufacturing of BNT162b2" | phase 3 | 2.4 | July 27, 2020 | -1.8 | December 2, 2020 | United Kingdom | 2020-10 |
62 | phase 2 | Vaxart | Kindred Biosciences | United States | Vaxart’s | viral vector | https://kindredbio.com/frontpage/kindred-biosciences-announces-expansion-of-manufacturing-agreement-with-vaxart-for-covid-19-and-other-vaccine-candidates/ | October 7, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "manufacture of Vaxart’s oral vaccine for COVID-19" | phase 1 | 2020-10 | ||||||
63 | authorized | AstraZeneca/Oxford | Siam Bioscience | Thailand | AZD1222 | viral vector | https://www.reuters.com/article/us-health-coronavirus-astrazeneca-thaila/thailand-to-make-supply-astrazenecas-covid-19-vaccine-idUSKBN26X1GC | October 27, 2020 | 2020 Q4 | eight months | 7-8 | 7-9 | AZ said in April that they were aiming to start production here by June 2021: https://www.astrazeneca.com/country-sites/thailand/press-relaese/thai20210428.html | entire process, active ingredient, others | - | phase 2/3 | 5.1 | May 26, 2020 | -2.1 | December 30, 2020 | United Kingdom, Argentina | 2020-10 |
64 | authorized | Gamaleya | União Química | Brazil | Sputnik V | viral vector | https://rdif.ru/Eng_fullNews/6034/ | October 30, 2020 | 2020 Q4 | seven months | 7-8 | 7-9 | União Química made the first batch on May 20, 2021, according to news report: https://www.reuters.com/article/saude-covid-lote-uniaoquimica-idBRKCN2D129S-OBRDN | entire process, active ingredient, others | - | phase 3 | 2.1 | August 28, 2020 | -1.7 | December 21, 2020 | Belarus | 2020-10 |
65 | authorized | Johnson & Johnson | Aspen | South Africa | Ad26.COV2-S | viral vector | https://www.aspenpharma.com/2020/11/02/aspen-announces-agreement-with-johnson-johnson-to-manufacture-investigational-covid-19-vaccine-candidate/ | November 2, 2020 | 2020 Q4 | five months | 5-6 | 4-6 | On March 12, 2021, Aspen said that it had completed the technology transfer: https://www.bloomberg.com/news/articles/2021-03-12/aspen-pharmacare-to-deliver-j-j-vaccines-in-next-three-months | entire process, active ingredient, others | "for the technical transfer and proposed commercial manufacture of their COVID-19 vaccine candidate, Ad26.COV2-S" | phase 3 | 2.8 | August 10, 2020 | -3.8 | February 27, 2021 | United States | 2020-11 |
66 | authorized | Gamaleya | Pharmasyntez | Russia | Sputnik V | viral vector | https://pharmasyntez.com/en/press-center/news/pharmasyntez-will-produce-the-covid-19-sputnik-v-vaccine/?sphrase_id=15954 | November 6, 2020 | 2020 Q4 | 2.3 | August 28, 2020 | -1.5 | December 21, 2020 | Belarus | 2020-11 | |||||||
67 | authorized | Pfizer/BioNTech | Croda | United Kingdom | BNT162b2 | mRNA | https://www.croda.com/en-gb/news/2020/11/pfizer-croda | November 10, 2020 | 2020 Q4 | one month | 1-2 | 1-3 | By December 2020 Croda was already suplying Pfizer/BioNTech. https://www.yorkpress.co.uk/news/18925837.covid-vaccine-yorkshire-firm-croda-make-key-parts-jab/ | entire process, active ingredient, others | "The application of our innovative capabilities is testament to the strong progress we have made to create industry-leading drug delivery systems, focused on developing speciality excipients and adjuvants to improve the effectiveness and stability of complex drug actives and vaccines." | phase 3 | 3.5 | July 27, 2020 | -0.7 | December 2, 2020 | United Kingdom | 2020-11 |
68 | authorized | Gamaleya | Tibet Rhodiola Pharma | China | Sputnik V | viral vector | https://www.reuters.com/article/health-coronavirus-vaccine-russia/tibet-rhodiola-pharma-obtains-right-to-develop-russias-sputnik-v-vaccine-in-china-idUSP8N2HR02H | November 11, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "develop, manufacture, import or commercialize Russia’s COVID-19 vaccine, Sputnik V, in mainland China, Hong Kong, Macau and Taiwan." | phase 3 | 2.5 | August 28, 2020 | -1.3 | December 21, 2020 | Belarus | 2020-11 | |
69 | authorized | Gamaleya | GL Rapha | South Korea | Sputnik V | viral vector | https://sputnikvaccine.com/newsroom/pressreleases/rdif-and-gl-rapha-agree-to-produce-over-150-million-doses-of-the-sputnik-v-vaccine-in-south-korea/ | November 13, 2020 | 2020 Q4 | one month | 1-2 | 1-3 | December 2020 | entire process, active ingredient, others | "produce over 150 million doses per year" | phase 3 | 2.5 | August 28, 2020 | -1.2 | December 21, 2020 | Belarus | 2020-11 |
70 | abandoned | CureVac | Rentschler Biopharma | Germany | CVnCoV | RNA-based | https://www.curevac.com/en/2021/02/01/curevac-and-rentschler-biopharma-ramp-up-manufacturing-of-covid-19-vaccine-cvncov/ | November 15, 2020 | 2020 Q4 | three months | 3-4 | 1-3 | February 1, 2021 | entire process, active ingredient, others | "largescale cGMP (Current Good Manufacturing Practice) production of the formulated mRNA for CVnCoV" | phase 2 | -0.1 | November 19, 2020 | abandoned | abandoned | 2020-11 | |
71 | authorized | Pfizer/BioNTech | Delpharm | France | BNT162b2 | mRNA | https://pharmacie.ma/index/generate-pdf/article_id/6911 | November 18, 2020 | 2020 Q4 | six months | 5-6 | 4-6 | According to several news reports, including in www.fr24news.com, Delpharm would start producing in Saint-Rémy-sur-Avre from April 2021 | entire process, active ingredient, others | "une partie des doses du vaccin anti-Covid-19 développé par Pfizer et BioNTech" | phase 3 | 3.7 | July 27, 2020 | -0.5 | December 2, 2020 | United Kingdom | 2020-11 |
72 | abandoned | CureVac | WACKER | Germany | CVnCoV | RNA-based | https://www.curevac.com/en/2020/11/23/curevac-and-wacker-sign-manufacturing-contract-for-curevacs-covid-19-vaccine-candidate-cvncov/ | November 23, 2020 | 2020 Q4 | eight months | 7-8 | 7-9 | "first half of 2021" | entire process, active ingredient, others | "ramp up GMP (Good Manufacturing Practice) production of the mRNA drug substance for CVnCoV" | phase 2 | 0.1 | November 19, 2020 | abandoned | abandoned | 2020-11 | |
73 | authorized | Gamaleya | Hetero Biopharma | India | Sputnik V | viral vector | https://rdif.ru/Eng_fullNews/6096/ | November 27, 2020 | 2020 Q4 | six months | 5-6 | 4-6 | "beginning of 2021" | entire process, active ingredient, others | "to produce in India over 100 million doses" | phase 3 | 3.0 | August 28, 2020 | -0.8 | December 21, 2020 | Belarus | 2020-11 |
74 | phase 3 | Inovio | Kaneka Eurogentec | Belgium | INO-4800 | DNA-based | http://ir.inovio.com/news-releases/news-releases-details/2020/INOVIO-Expands-Global-Manufacturing-Consortium-For-Its-COVID-19-Vaccine-Candidate-INO-4800-With-Addition-of-Kaneka-Eurogentec-S.A/default.aspx | December 3, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "manufacture INOVIO's COVID-19 vaccine candidate INO-4800 at their industry-leading GMP plasmid production scales" | phase 2 | 0.3 | November 24, 2020 | 2020-12 | ||||
75 | authorized | Gamaleya | Karaganda Pharmaceutical | Kazakhstan | Sputnik V | viral vector | https://www.themoscowtimes.com/2021/02/16/kazakhstan-to-roll-out-first-locally-produced-sputnik-vaccine-a72971 | December 4, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "local production of Sputnik V" | phase 3 | 3.2 | August 28, 2020 | -0.6 | December 21, 2020 | Belarus | 2020-12 | |
76 | authorized | AstraZeneca/Oxford | HALIX | Netherlands | AZD1222 | viral vector | https://www.halix.nl/2020/12/08/halix-signs-agreement-astrazeneca-commercial-manufacture-covid-19-vaccine/ | December 8, 2020 | 2020 Q4 | four months | 3-4 | 4-6 | According to news reports, Halix was already producting by late March 2021: https://fortune.com/2021/03/26/astrazeneca-plant-halix-covid-vaccines-ema/ Halix appears to have been collaborating with Oxford prior to this. | entire process, active ingredient, others | "commercial manufacturing of drug substance at its state-of-the-art cGMP facility at the Leiden Bio Science Park in the Netherlands" | phase 2/3 | 6.4 | May 26, 2020 | -0.7 | December 30, 2020 | United Kingdom, Argentina | 2020-12 |
77 | abandoned | CureVac | Fareva | France | CVnCoV | RNA-based | https://www.curevac.com/2020/12/09/curevac-and-fareva-sign-agreement-for-fill-finish-manufacturing-of-curevacs-covid-19-vaccine-candidate-cvncov/ | December 9, 2020 | 2020 Q4 | six months | 5-6 | 4-6 | May 2021, according to France Industry Minister Agnès Pannier-Runacher | fill-and-finish | fill-and-finish | phase 2 | 0.7 | November 19, 2020 | abandoned | abandoned | 2020-12 | |
78 | authorized | Johnson & Johnson | Reig Jofre | Spain | Ad26.COV2-S | viral vector | https://www.reigjofre.com/en/noticias/item/reig-jofre-announces-technology-transfer-of-the-large-scale-manufacturing-in-spain-for-a-covid-19-vaccine-candidate/ | December 15, 2020 | 2020 Q4 | six months | 5-6 | 4-6 | In late April 2021 Reig Jofre said that the production delivery in expected to start in June 2021: https://cincodias.elpais.com/cincodias/2021/04/29/companias/1619693087_591444.html | entire process, active ingredient, others | "formulation, filling, and packaging of the vaccine candidate" | phase 3 | 4.2 | August 10, 2020 | -2.4 | February 27, 2021 | United States | 2020-12 |
79 | authorized | Bharat Biotech | Ocugen Inc | United States | Covaxin | inactivated virus | https://ir.ocugen.com/news-releases/news-release-details/ocugen-and-bharat-biotech-co-develop-covaxintm-whole-virion | December 22, 2020 | 2020 Q4 | - | - | - | entire process, active ingredient, others | "Ocugen will have US rights to the vaccine candidate and, in collaboration with Bharat Biotech, will be responsible for clinical development, registration, and commercialization for the US market. The companies have begun collaborating and will finalize details of the definitive agreement in the next few weeks. This collaboration leverages Ocugen’s vaccine expertise, and its R&D and regulatory capabilities in the US." | phase 3 | 1.0 | November 23, 2020 | -0.4 | January 3, 2021 | India | 2020-12 | |
80 | authorized | AstraZeneca/Oxford | JCR Pharmaceutical | Japan | AZD1222 | viral vector | https://pj.jiho.jp/article/243572 | December 30, 2020 | 2020 Q4 | three months | 3-4 | 1-3 | In a March 4, 2021 statement the JCR said that they were already manufacturing the bulk substance. "JCR has been manufacturing the bulk substance of the vaccine at JCR’s existing plant" https://ssl4.eir-parts.net/doc/4552/tdnet/1941163/00.pdf | entire process, active ingredient, others | "JCR Pharmaceuticals has signed a pact with AstraZeneca for the domestic production of vaccine solutions for AZD1222, the UK giant’s COVID-19 shot being codeveloped with Oxford University, the Japanese company said on December 30." | autorized | 7.2 | May 26, 2020 | 0.0 | December 30, 2020 | United Kingdom, Argentina | 2020-12 |
81 | authorized | Moderna | Recipharm AB | Sweden | mRNA-1273 | mRNA | https://www.recipharm.com/press/recipharm-and-moderna-finalize-agreement-aseptic-drug-product-manufacturing-and-fill-finish | December 30, 2020 | 2020 Q4 | three months | 3-4 | 1-3 | "supply will commence in early 2021" | entire process, active ingredient, others | "aseptic drug product manufacturing and fill-finish" | autorized | 5.1 | July 27, 2020 | 0.4 | December 18, 2020 | United States | 2020-12 |
82 | phase 3 | Inovio | Advaccine Biopharmaceuticals | China | INO-4800 | DNA-based | https://ir.inovio.com/news-releases/news-releases-details/2021/INOVIO-and-Advaccine-Announce-Exclusive-Partnership-To-Commercialize-COVID-19-DNA-Vaccine-Candidate-INO-4800-in-Greater-China/default.aspx | January 4, 2021 | 2021 Q1 | - | - | - | entire process, active ingredient, others | "Advaccine will have the exclusive right to develop, manufacture and commercialize INO-4800 within Greater China, inclusive of Mainland China, Hong Kong, Macao, and Taiwan." | phase 2 | 1.3 | November 24, 2020 | 2021-1 | ||||
83 | abandoned | CureVac | Bayer | Germany | CVnCoV | RNA-based | https://media.bayer.com/baynews/baynews.nsf/id/CureVac-and-Bayer-join-forces-on-COVID-19-vaccine-candidate-CVnCoV | January 7, 2021 | 2021 Q1 | - | - | - | entire process, active ingredient, others | "Bayer will support the further development, supply and key territory operations of CureVac´s COVID-19 vaccine candidate CVnCoV" | phase 3 | 1.6 | November 19, 2020 | abandoned | abandoned | 2021-1 | ||
84 | authorized | Finlay Institute | Pasteur Institute | Iran | Soberana | protein-based | https://www.finlay.edu.cu/blog/joint-statement-of-finlay-vaccine-institute-and-pasteur-institute-of-iran/ | January 8, 2021 | 2021 Q1 | six months | 5-6 | 4-6 | Iran started producing in July 2021, six months after the January 2021 agreement: https://www.reuters.com/business/healthcare-pharmaceuticals/cuba-says-iran-start-producing-one-its-covid-19-vaccines-2021-07-29/ | -1.9 | March 8, 2021 | -7.4 | August 20, 2021 | Cuba | 2021-1 | |||
85 | authorized | Novavax | Baxter | Germany | NVX-CoV2373 | protein-based | https://www.baxter.com/baxter-newsroom/baxter-biopharma-solutions-announces-sterile-manufacturing-agreement-novavax-covid | January 11, 2021 | 2021 Q1 | - | - | - | - | entire process, active ingredient, others | "sterile manufacturing services for NVX-CoV2373, Novavax’ COVID-19 recombinant nanoparticle vaccine candidate with Matrix-M™ adjuvant" | phase 3 | 3.0 | October 12, 2020 | -11.3 | December 20, 2021 | EMA | 2021-1 |
86 | authorized | Sinovac | Pharmaniaga Berhad | Malaysia | CoronaVac | inactivated virus | https://www.thestar.com.my/business/business-news/2021/01/13/pharmaniaga-to-produce-sinovac-covid-19-vaccines | January 11, 2021 | 2021 Q1 | three months | 3-4 | 1-3 | "Phamaniaga Bhd has the capacity to manufacture two million doses of Covid-19 vaccine developed by China’s Sinovac Life Sciences Co Ltd per month beginning March this year." https://www.thestar.com.my/business/business-news/2021/01/13/pharmaniaga-to-produce-sinovac-covid-19-vaccines | fill-and-finish | fill-and-finish | autorized | 6.3 | July 2, 2020 | 0.0 | January 11, 2021 | Indonesia | 2021-1 |
87 | authorized | Sinovac | Lekhim | Ukraine | CoronaVac | inactivated virus | https://www.reuters.com/article/us-health-coronavirus-ukraine-vaccine/ukraine-pharma-group-to-supply-5-million-doses-of-sinovac-covid-19-vaccine-in-first-half-idUSKBN29H1QZ | January 12, 2021 | 2021 Q1 | three months | 3-4 | 1-3 | "Ukrainian company Lekhim will deliver the first batch of the Chinese-made Sinovac COVID-19 vaccines to Ukraine by March 15, the company said on Thursday." https://www.reuters.com/article/us-health-coronavirus-ukraine-vaccine/ukraine-firm-lekhim-will-deliver-first-batch-of-sinovac-vaccines-by-march-15-idUSKBN2AW1FB | entire process, active ingredient, others | - | autorized | 6.4 | July 2, 2020 | 0.0 | January 11, 2021 | Indonesia | 2021-1 |
88 | authorized | Pfizer/BioNTech | Baxter | Germany | BNT162b2 | mRNA | https://www.reuters.com/article/health-coronavirus-vaccines-baxter-intl/update-1-baxter-to-start-production-in-germany-of-biontech-pfizer-vaccine-by-early-march-idUSL8N2JO32D | January 13, 2021 | 2021 Q1 | two months | 1-2 | 1-3 | "The U.S. healthcare group plans to start production at its facility in Halle, North Rhine-Westphalia, in late February or early March, said Juergen Fleischer, personnel chief at Baxter Germany." https://www.reuters.com/article/health-coronavirus-vaccines-baxter-intl/update-1-baxter-to-start-production-in-germany-of-biontech-pfizer-vaccine-by-early-march-idUSL8N2JO32D | fill-and-finish | fill and finish | autorized | 5.6 | July 27, 2020 | 1.4 | December 2, 2020 | United Kingdom | 2021-1 |
89 | authorized | AstraZeneca/Oxford | Insud Pharma | Spain | AZD1222 | viral vector | https://www.insudpharma.com/spanish-group-insud-pharma-signs-agreement-astrazeneca-manufacture-covid-19-vaccine-candidate | January 20, 2021 | 2021 Q1 | one month | 1-2 | 1-3 | "AstraZeneca has partnered with the Spanish pharmaceutical group Insud Pharma to participate in the manufacturing of the vaccine vials developed in collaboration with Oxford University to fight against the COVID-19 pandemic. Universal Farma's facilities in Azuqueca de Henares (Guadalajara) will start to fill and package the AZD1222 vials in February 2021." https://www.investinspain.org/en/news/2021/astrazeneca-insudpharma-produce-vaccine | fill-and-finish | "The Spanish pharmaceutical group Insud Pharma will provide vial filling and packaging of AZD1222, the adenovirus vector COVID-19 vaccine candidate developed by the University of Oxford and licensed by AstraZeneca. Manufacturing will take place in the plant operated by the group's industrial unit, Chemo. AZD1222 is currently in clinical trials and approved for emergency supply in UK and other countries." | autorized | 7.9 | May 26, 2020 | 0.7 | December 30, 2020 | United Kingdom, Argentina | 2021-1 |
90 | authorized | Gamaleya | VisCoran | Turkey | Sputnik V | viral vector | https://www.viscoran.com/-Sputnik-Vnin-Turkiyede-uretimi-icin-imzalar-atildi-d3 | January 21, 2021 | 2021 Q1 | six months | 5-6 | 4-6 | In April 2021 the RDIF said that VisCoran was going to start producing "in the upcoming months." "To date Viscoran İlaç has carried out necessary studies for localization of the product and aims to launch the production in the country in the upcoming months at several facilities." https://sputnikvaccine.com/newsroom/pressreleases/rdif-and-viscoran-ilac-agree-to-produce-the-sputnik-v-vaccine-in-turkey/ | entire process, active ingredient, others | - | autorized | 4.8 | August 28, 2020 | 1.0 | December 21, 2020 | Belarus | 2021-1 |
91 | authorized | Gamaleya | Duopharma Biotech | Malaysia | Sputnik V | viral vector | https://disclosure.bursamalaysia.com/FileAccess/apbursaweb/download?id=111133&name=EA_GA_ATTACHMENTS | January 26, 2021 | 2021 Q1 | - | - | - | fill-and-finish | "Duopharma Biotech has invested in vaccine fill & finish and cold chain facilities to align with Malaysia’s aim to advance towards developing in-country vaccines inthe long term" | autorized | 5.0 | August 28, 2020 | 1.2 | December 21, 2020 | Belarus | 2021-1 | |
92 | authorized | Pfizer/BioNTech | Sanofi | France | BNT162b2 | mRNA | https://www.sanofi.com/en/media-room/press-releases/2021/2021-01-27-07-30-00 | January 27, 2021 | 2021 Q1 | six months | 5-6 | 4-6 | "summer of 2021" | fill-and-finish | "Sanofi will perform late-stage manufacturing to supply over 125 million doses of COVID-19 vaccine for the European Union" | autorized | 6.0 | July 27, 2020 | 1.8 | December 2, 2020 | United Kingdom | 2021-1 |
93 | authorized | Pfizer/BioNTech | Novartis | Switzerland | BNT162b2 | mRNA | https://www.novartis.com/news/media-releases/novartis-signs-initial-agreement-provide-manufacturing-capacity-pfizer-biontech-covid-19-vaccine | January 29, 2021 | 2021 Q1 | six months | 5-6 | 4-6 | "Subject to reaching a final agreement, Novartis plans to commence production in the second quarter of 2021 at its state-of-the art aseptic manufacturing plant in Stein." | fill-and-finish | "Novartis plans to take bulk mRNA active ingredient from BioNTech and fill this into vials under aseptic conditions for shipment back to BioNTech for their distribution to healthcare system customers around the world." | autorized | 6.1 | July 27, 2020 | 1.9 | December 2, 2020 | United Kingdom | 2021-1 |
94 | authorized | Pfizer/BioNTech | Allergopharma | Germany | BNT162b2 | mRNA | https://allergopharmanexter.pl/application/files/1516/1425/3193/Press-Release-COVID-19.pdf | February 1, 2021 | 2021 Q1 | three months | 3-4 | 1-3 | From April 30, 2021. "After a very short preparation period, Allergopharma officially starts production of the BioNTech vaccine Comirnaty ® in Reinbek today." https://www.allergopharma.de/unternehmen/aktuelle-nachrichten-covid-vaccine/ | entire process, active ingredient, others | "The company Aller-gopharma will soon be producing the COVID-19 vaccine of the Mainz company BioNTech in new, ultra-modern production facilities in Reinbek near Hamburg (see photo)." | autorized | 6.2 | July 27, 2020 | 2.0 | December 2, 2020 | United Kingdom | 2021-2 |
95 | authorized | AstraZeneca/Oxford | KM Biologics | Japan | AZD1222 | viral vector | https://pj.jiho.jp/article/244060 | February 1, 2021 | 2021 Q1 | two months | 1-2 | 1-3 | KM Biologics started production in March 2021. https://pj.jiho.jp/article/244060 | fill-and-finish | "Daiichi Sankyo Biotech and KM Biologics will undertake production, such as filling vials and packaging, while Daiichi Sankyo and Meiji Seika Pharma will support shipping." | autorized | 8.2 | May 26, 2020 | 1.1 | December 30, 2020 | United Kingdom, Argentina | 2021-2 |
96 | authorized | CanSino Biologics | Drugmex | Mexico | Ad5-nCoV | viral vector | https://www.reuters.com/article/us-health-coronavirus-mexico-vaccine/chinas-cansino-says-first-vaccines-packaged-in-mexico-will-be-ready-in-march-idUSKCN2AS0P0 | February 1, 2021 | 2021 Q1 | two months | 1-2 | 1-3 | The first batch was out by March 2021: https://www.gob.mx/sre/prensa/the-first-covid-19-vaccines-packaged-in-mexico-leave-the-drugmex-plant | fill-and-finish | fill-and-finish | phase 3 | 5.2 | August 26, 2020 | -0.3 | February 10, 2021 | Mexico | 2021-2 |
97 | authorized | Novavax | Biologics Manufacturing Centre, Canada | Canada | NVX-CoV2373 | protein-based | https://nrc.canada.ca/en/research-development/nrc-facilities/biologics-manufacturing-centre | February 2, 2021 | 2021 Q1 | six months | 5-6 | 4-6 | "end of July 2021" | entire process, active ingredient, others | "Government of Canada signed a memorandum of understanding with Novavax in February 2021 to pursue options to produce its COVID-19 vaccine" | phase 3 | 3.7 | October 12, 2020 | -10.5 | December 20, 2021 | EMA | 2021-2 |
98 | abandoned | CureVac | GSK | United Kingdom | CVnCoV | RNA-based | https://www.gsk.com/en-gb/media/press-releases/gsk-and-curevac-to-develop-next-generation-mrna-covid-19-vaccines/ | February 3, 2021 | 2021 Q1 | - | - | - | entire process, active ingredient, others | "GSK will also support the manufacture of up to 100 million doses of CureVac’s first generation COVID-19 vaccine candidate CVnCoV in 2021" | phase 3 | 2.5 | November 19, 2020 | abandoned | abandoned | 2021-2 | ||
99 | authorized | AstraZeneca/Oxford | Daiichi Sankyo | Japan | AZD1222 | viral vector | https://www.daiichisankyo.com/files/news/pressrelease/pdf/202102/20210205_E.pdf | February 5, 2021 | 2021 Q1 | two months | 1-2 | 1-3 | Daiichi Sankyo announced in March 12, 2021, that they started manufacturing. https://www.daiichisankyo.com/files/news/pressrelease/pdf/202103/20210312_E1.pdf | fill-and-finish | "Daiichi Sankyo will use undiluted solutions provided by AstraZeneca to manufacture COVID-19 vaccines in the country, including vial filling and packaging, in accordance with the outsourcing agreement." | autorized | 8.4 | May 26, 2020 | 1.2 | December 30, 2020 | United Kingdom, Argentina | 2021-2 |
100 | authorized | Pfizer/BioNTech | Merck | United States | BNT162b2 | mRNA | https://www.emdgroup.com/en/news/biontech-strategic-partnership-04-02-2021.html | February 5, 2021 | 2021 Q1 | - | - | - | entire process, active ingredient, others | lipid production | autorized | 6.3 | July 27, 2020 | 2.1 | December 2, 2020 | United Kingdom | 2021-2 |