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1 | This spreadsheet contains COVID-19 studies that suggest the longer-term or chronic issues of COVID infections and reinfections. |
2 | The studies are collected by topical area (see the tabs at the bottom). |
3 | Each study has diverse methodologies. Some study people with COVID versus those without, look specifically at mild COVID versus severe, or evaluate those with Long COVID against a control group without post-acute symptoms. Some studies explore the impact of the wildtype virus, others evaluate Delta, Omicron and later variants. Some studies predate vaccines, while many evaluate the impact of COVID on a vaccinated population. And, several studies examine the affect of repeat or breakthrough infections versus a single infection. Methodologies vary widely. |
4 | I've tried to include any unfamiliar abbreviations within the citations of each study or in the glossary tab. |
5 | Take care evaluating the studies merely by the brief passages captured here. If you have any interest to learn more, click through to each study to review its methodlogy and results. |
6 | I hope that by capturing these studied in one place, it helps to advance people's knowledge of COVID's ongoing risks and encourages more caution as to the impact of accumulating reinfections. |
7 | |
8 | List maintainedby Augie Ray |
9 | https://mastodon.social/@augieray I do most of my posting about COVID studies and risks on Mastodon. |
10 | https://twitter.com/augieray I rarely post on Twitter, but I can be reached on the platform. |
11 | https://www.linkedin.com/in/augieray/ I occasionally post on LinkedIn urging leaders to take more care in protecting the health of workers as COVID risks persist. |
12 | https://bsky.app/profile/augieray.bsky.social I occasionally post COVID updates to BlueSky. |
13 | https://medium.com/@augieray_66704 I usually post weekly longer-form updates on current COVID risks and trends in the US and information about new studies on COVID |
| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | AA | |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 239 | |||||||||||||||||||||||||
3 | Endothelial cell infection and endotheliitis in COVID-19 | 2020-04-20 | https://doi.org/10.1016/S0140-6736(20)30937-5 | Zsuzsanna Varga | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext | Here we demonstrate endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19. Our findings show the presence of viral elements within endothelial cells and an accumulation of inflammatory cells, with evidence of endothelial and inflammatory cell death. These findings suggest that SARS-CoV-2 infection facilitates the induction of endotheliitis in several organs as a direct consequence of viral involvement (as noted with presence of viral bodies) and of the host inflammatory respons. | |||||||||||||||||||||
4 | Cardiac Involvement in Patients Recovered From COVID-2019 Identified Using Magnetic Resonance Imaging | 2020-05-12 | https://doi.org/10.1016%2Fj.jcmg.2020.05.004 | PMC7214335 | Lu Huang | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214335/ | Fifteen patients (58%) had abnormal CMR findings on conventional CMR sequences: myocardial edema was found in 14 (54%) patients and LGE was found in 8 (31%) patients | ||||||||||||||||||||
5 | Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) | 2020-07-27 | https://doi.org/10.1001%2Fjamacardio.2020.3557 | PMC7385689 | Valentina O. Puntmann | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385689/ | In this study of a cohort of German patients recently recovered from COVID-19 infection, CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis. | ||||||||||||||||||||
6 | Increased risk of acute stroke among patients with severe COVID-19: a multicenter study and meta-analysis | 2020-09-12 | https://doi.org/10.1111/ene.14535 | T. Siepmann | https://onlinelibrary.wiley.com/doi/full/10.1111/ene.14535 | Synthesized analysis of data from our multicenter study and previously published cohorts indicates that severity of COVID-19 is associated with an increased risk of acute stroke. Risk of acute stroke was increased for patients with severe compared to non-severe COVID-19 (RR = 4.18, 95% CI: 1.7–10.25; P = 0.002). | |||||||||||||||||||||
7 | Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered from Coronavirus Disease 2019 (COVID-19) | 2020-11-01 | https://doi.org/10.1001/jamacardio.2020.3557 | 32730619 | Puntmann, V.O. | https://www.scopus.com/record/display.uri?eid=2-s2.0-85089103970&origin=inward&txGid=fc726298163e320d0cac8957f532349c | In this study of a cohort of German patients recently recovered from COVID-19 infection, CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis. | ||||||||||||||||||||
8 | Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations | 2020-12-08 | https://doi.org/10.1182/bloodadvances.2020003471 | Caroline Diorio | https://ashpublications.org/bloodadvances/article/4/23/6051/474421/Evidence-of-thrombotic-microangiopathy-in-children | Of the 19 patients for whom complete clinical criteria were available, 17 (89%) met criteria for TMA. A high proportion of tested children with SARS-CoV-2 infection had evidence of complement activation and met clinical and diagnostic criteria for TMA (thrombotic microangiopathy). | |||||||||||||||||||||
9 | SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group | 2021-04-21 | https://doi.org/10.1161%2FSTROKEAHA.120.032927 | PMC8078130 | Shima Shahjouei | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078130/ | We observed a considerably higher rate of large vessel occlusions, a much lower rate of small vessel occlusion and lacunar infarction, and a considerable number of young stroke when compared with the population studies before the pandemic. | ||||||||||||||||||||
10 | Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin | 2021-08-23 | https://doi.org/10.1186/s12933-021-01359-7 | Etheresia Pretorius | https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01359-7 | We show that plasma samples from Long COVID/PASC still contain large anomalous (amyloid) deposits (microclots). We also show that these microclots in both acute COVID-19 and Long COVID/PASC plasma samples are resistant to fibrinolysis (compared to plasma from controls and T2DM), even after trypsinisation. | |||||||||||||||||||||
11 | Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up | 2021-09-15 | https://doi.org/10.1016/j.ijcard.2021.06.056 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8253670/ | Viviana Maestrini | https://pubmed.ncbi.nlm.nih.gov/34224766/ | Cardiovascular evaluation in COVID-19 patients is crucial since the occurrence of CVD in hospitalized COVID-19 patients is common (28%), requires specific treatment and increases the risk of in-hospital mortality. Persistence or delayed presentation of CVD at 1-month (9%) and persistent symptoms at 1-year follow-up (48%) suggest the need for monitoring COVID-19 survivors. | ||||||||||||||||||||
12 | Symptom Persistence Despite Improvement in Cardiopulmonary Health – Insights from longitudinal CMR, CPET and lung function testing post-COVID-19 | 2021-10-20 | https://doi.org/10.1016/j.eclinm.2021.101159 | Mark Philip Cassar | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00439-9/fulltext | At 2-3 months, 83% of patients had at least one cardiopulmonary symptom versus 33% of controls. By 6 months, 52% of patients remained symptomatic. On CMR (cardiac and lung magnetic resonance imaging), indexed right ventricular (RV) end-diastolic volume (-4·3 mls/m2, P=0·005) decreased and RV ejection fraction (+3·2%, P=0·0003) increased. Lung parenchymal abnormalities and peak V̇O2, although better, were abnormal in patients versus controls. | |||||||||||||||||||||
13 | Long term effects of mild severity COVID‑19 on right ventricular functions | 2021-12-01 | https://doi.org/10.1007/s10554-021-02340-x | https://pmc.ncbi.nlm.nih.gov/articles/PMC8274467/ | Fatih Akkaya | https://pubmed.ncbi.nlm.nih.gov/34251551/ | This results suggested that RV-GLS (RV global longitudinal strain) and RV-FWLS (RV free wall longitudinal strain) decreased in the long term (third month) follow-up of patients treated for mild severity COVID-19 disease. Subclinical RV (Right ventricular) dysfunction may be observed in patients after mild severity COVID-19. RV diamaters, systolic pulmonary artery pressure (sPAP) and RV myocardial performance index (RV MPI) were significantly higher in the COVID-19 patients compared to control group. | ||||||||||||||||||||
14 | Development of post-COVID-19 cardiovascular events: an analysis of clinical features and risk factors from a single hospital retrospective study | 2021-12-10 | https://doi.org/10.53854/liim-2904-6 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8805477/ | Gianluca Cuomo | https://pubmed.ncbi.nlm.nih.gov/35146362/ | In patients with COVID-19, the development of a cardiovascular event occurs quite frequently and is mainly seen in elderly subjects with comorbidities (especially hypertension) in the presence of a severe respiratory picture. A cardiovascular event developed in 15.7% of the subjects. These were mainly pulmonary embolism (9.4%), followed by arrhythmias (3.3%), myocardial infarction (2.3%), and myocarditis (0.8%). | ||||||||||||||||||||
15 | Myocardial fibrosis occurs in non-hospitalised patients with chronic symptoms after COVID-19 | 2022-01-26 | https://doi.org/10.1016%2Fj.ijcha.2022.100964 | PMC8789662 | A. Krishnan | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789662/ | In our cohort of recovering patients, managed in the community for initial COVID-19 infection and complaining of persistent symptoms, there is a larger than expected burden of myocardial injury demonstrated by presence of scar on LGE imaging by 12 months. | ||||||||||||||||||||
16 | Long-term cardiovascular outcomes of COVID-19 | 2022-02-07 | https://doi.org/10.1038/s41591-022-01689-3 | Xie, Y. | https://www.nature.com/articles/s41591-022-01689-3 | Individuals with COVID-19 are at increased risk of incident cardiovascular disease spanning several categories, including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure and thromboembolic disease. These risks and burdens were evident even among individuals who were not hospitalized during the acute phase of the infection and increased in a graded fashion according to the care setting during the acute phase (non-hospitalized, hospitalized and admitted to intensive care). | |||||||||||||||||||||
17 | Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study | 2022-02-22 | https://doi.org/10.1136/bmj-2021-069590 | Ioannis Katsoularis | https://www.bmj.com/content/377/bmj-2021-069590 | Incidence rate ratios were significantly increased 70 days after covid-19 for deep vein thrombosis, 110 days for pulmonary embolism, and 60 days for bleeding. | |||||||||||||||||||||
18 | FOLLOW-UP OF HOSPITALIZED COVID-19 SURVIVORS: ASSESSMENT OF SHORT AND LONG-TERM CARDIOVASCULAR SEQUELAE AFTER SARS-COV-2 INFECTION | 2022-04-01 | https://doi.org/10.1016/S0735-1097(22)03148-5 | Lucia Ilaria Birtolo | https://www.jacc.org/doi/full/10.1016/S0735-1097%2822%2903148-5 | Our preliminary data showed persistent or delayed onset of cardiovascular involvement (16%) at short-term follow-up and persistent symptoms (45%) at long-term follow-up. 60% of survivors showed persistent chest CT abnormalities and among those 28 % complained of persistent cardiopulmonary symptoms at long term follow-up. | |||||||||||||||||||||
19 | Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study | 2022-04-06 | https://doi.org/10.1136/bmj-2021-069590 | Ioannis Katsoularis | https://www.bmj.com/content/377/bmj-2021-069590 | Compared with the control period, incidence rate ratios were significantly increased 70 days after covid-19 for deep vein thrombosis, 110 days for pulmonary embolism, and 60 days for bleeding. The risk ratios during days 1-30 after covid-19 were 4.98 (4.96 to 5.01) for deep vein thrombosis, 33.05 (32.8 to 33.3) for pulmonary embolism, and 1.88 (1.71 to 2.07) for bleeding, after adjusting for the effect of potential confounders. | |||||||||||||||||||||
20 | Cardiac Manifestations Of Coronavirus (COVID-19) | 2022-05-02 | Basu-Ray I | https://www.ncbi.nlm.nih.gov/books/NBK556152/ | Cardiac damage has been noted even without clinical features of respiratory disease. On the one hand, respiratory symptoms are worse in COVID-19 affected patients with preexisting cardiac ailments; however, new-onset cardiac dysfunction is common in this subset. | ||||||||||||||||||||||
21 | Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician | 2022-05-04 | https://doi.org/10.1007/s11883-022-01032-8 | Diana L. Tobler | https://link.springer.com/article/10.1007/s11883-022-01032-8 | Long-term follow-up shows increased incidence of arrhythmia, heart failure, acute coronary syndrome, right ventricular dysfunction, myocardial fibrosis, hypertension, and diabetes mellitus. There is increased mortality in COVID-19 patients after hospital discharge, and initial myocardial injury is associated with increased mortality. | |||||||||||||||||||||
22 | Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study | 2022-07-15 | https://doi.org/10.1038/s41467-022-31834-y | Husam M. Salah | https://www.nature.com/articles/s41467-022-31834-y | Over a median follow up of 367 days, 10,979 incident heart failure events occurred. After adjustments, COVID-19 hospitalization was associated with a 45% higher hazard of incident heart failure (hazard ratio = 1.45; 95% confidence interval: 1.39–1.51), with more pronounced associations among patients who were younger (P-interaction = 0.003), White (P-interaction = 0.005), or who had established cardiovascular disease (P-interaction = 0.005). In conclusion, COVID-19 hospitalization is associated with increased risk of incident heart failure. | |||||||||||||||||||||
23 | Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodies | 2022-07-19 | https://doi.org/10.1002/clc.23886 | Olga Blagova MD, PhD | https://onlinelibrary.wiley.com/doi/10.1002/clc.23886 | COVID-19 can lead to long-term severe post-COVID myoendocarditis, that is characterized by prolonged persistence of coronavirus in cardiomyocytes, endothelium, and macrophages (up to 18 months) in combination with high immune activity. | |||||||||||||||||||||
24 | Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodies | 2022-07-19 | https://doi.org/10.1002/clc.23886 | Olga Blagova | https://onlinelibrary.wiley.com/doi/10.1002/clc.23886 | COVID-19 can lead to long-term severe post-COVID myoendocarditis, that is characterized by prolonged persistence of coronavirus in cardiomyocytes, endothelium, and macrophages (up to 18 months) in combination with high immune activity. The new cardiac symptoms (congestive heart failure 3–4 New York Heart Association class with severe right ventricular involvement, various rhythm, and conduction disturbances) appeared 1–5 months following COVID-19. | |||||||||||||||||||||
25 | Evolution of right and left ventricle routine and speckle-tracking echocardiography in patients recovering from coronavirus disease 2019: a longitudinal study | 2022-07-21 | https://doi.org/10.1093/ehjci/jeab190 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8500022/ | Guy Baruch | https://pubmed.ncbi.nlm.nih.gov/34542601/ | A quarter of patients still have LV systolic dysfunction based on STE cut-offs. Moreover, LV STE does not improve significantly, implying subclinical LV dysfunction may be part and parcel of recovering from COVID-19 infection. A significant proportion [36 (45%)] of patients had some deterioration of longitudinal strain at follow-up, and 20 patients (25%) still had abnormal LV STE ∼3 months after COVID-19 acute infection. | ||||||||||||||||||||
26 | Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population: A retrospective cohort study from the TriNetX US collaborative networks | 2022-08-11 | https://doi.org/10.1016/j.eclinm.2022.101619 | Weijie Wang | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00349-2/fulltext | COVID-19 survivors were associated with increased risks of cerebrovascular diseases, such as stroke (HR [95% CI] = 1.618 [1.545-1.694]), arrhythmia related disorders, such as atrial fibrillation (HR [95% CI] = 2.407 [2.296-2.523]), inflammatory heart disease, such as myocarditis (HR [95% CI] =4.406 [2.890-6.716]), ischemic heart disease(IHD), like ischemic cardiomyopathy (HR [95% CI] = 2.811 [2.477-3.190]), other cardiac disorders, such as heart failure (HR [95% CI] =2.296 [2.200-2.396]) and thromboembolic disorders (e.g. pulmonary embolism: HR [95% CI] =2.648 [2.443-2.870]). The risks of two composite endpoints, major adverse cardiovascular event (HR [95% CI] = 1.871 [1.816–1.927]) and any cardiovascular outcome (HR [95% CI] = 1.552 [1.526–1.578]), were also higher in the COVID-19 survivors than in the controls. Moreover, the survival probability of the COVID-19 survivors dramatically decreased in all the cardiovascular outcomes. | |||||||||||||||||||||
27 | Cardiac postacute sequelae symptoms of SARS-CoV-2 in community-dwelling adults: cross-sectional study | 2022-09-04 | https://doi.org/10.1136/openhrt-2022-002084 | Oluwabunmi Ogungbe | https://openheart.bmj.com/content/9/2/e002084 | More than a third of persons with COVID-19 reported cardiac-related PASC symptoms. Prevalence of cardiac PASC was 43% and newly diagnosed cardiac conditions were 27%. The odds for cardiac-related PASC were higher among persons with underlying pre-existing conditions (adjusted OR (aOR): 2.00, 95% CI: 1.28 to 3.10) and among those who were hospitalised (aOR: 3.03, 95% CI: 1.58 to 5.83). | |||||||||||||||||||||
28 | Long-term cardiac pathology in individuals with mild initial COVID-19 illness | 2022-09-05 | https://doi.org/10.1038/s41591-022-02000-0 | Valentina O. Puntmann | https://www.nature.com/articles/s41591-022-02000-0 | Symptomatic individuals had higher heart rates and higher imaging values or contrast agent accumulation, denoting inflammatory cardiac involvement, compared to asymptomatic individuals. At follow-up (329 days (IQR, 274–383 days) after infection), 57% of participants had persistent cardiac symptoms. Diffuse myocardial edema was more pronounced in participants who remained symptomatic at follow-up as compared to those who improved. | |||||||||||||||||||||
29 | Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage | 2022-09-15 | https://doi.org/10.1111/imm.13577 | Arutha Kulasinghe | https://onlinelibrary.wiley.com/doi/10.1111/imm.13577#.ZAmL4C-VzGI.twitter | Host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS-CoV-2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra-pulmonary organs. | |||||||||||||||||||||
30 | Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic | 2022-09-29 | https://doi.org/10.1002/jmv.28187 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9839603/ | Yee Hui Yeo | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28187 | The SAPC (semi-annual percentage change) in the youngest and middle-age group in AMI-associated mortality increased by 5.3% (95% confidence interval [CI]: 1.6%–9.1%) and 3.4% (95% CI: 0.1%–6.8%), respectively. The excess death, defined as the difference between the observed and the predicted mortality rates, was most pronounced for the youngest (25–44 years) aged decedents, ranging from 23% to 34% for the youngest compared to 13%–18% for the oldest age groups. | ||||||||||||||||||||
31 | Cardiac impairment in Long Covid 1-year post SARS-CoV-2 infection | 2022-10-03 | https://doi.org/10.1093/eurheartj/ehac544.219 | A Roca-Fernandez | https://academic.oup.com/eurheartj/article/43/Supplement_2/ehac544.219/6744392?login=false | Cardiac impairment, other than myocarditis, is present in 1 in 5 individuals with Long Covid at 6 months, persisting in over half of those at 12 months. | |||||||||||||||||||||
32 | Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism | 2022-10-10 | https://doi.org/10.1186/s10020-022-00548-8 | Maitray A. Patel | https://molmed.biomedcentral.com/articles/10.1186/s10020-022-00548-8 | Long-COVID patients suffer prolonged, diffuse symptoms and poorer health. Vascular transformation blood biomarkers were significantly elevated in Long-COVID. Fourteen vasculature transformation blood biomarkers were significantly elevated in Long-COVID outpatients, versus acutely ill COVID-19 inpatients and healthy controls subjects (P < 0.05). | |||||||||||||||||||||
33 | Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank | 2022-10-24 | https://doi.org/10.1136/heartjnl-2022-321492 | Zahra Raisi-Estabragh | https://heart.bmj.com/content/109/2/119 | Individuals hospitalised (either with a primary or secondary daignoses of COVID-19) have increased risk of incident cardiovascular events across a range of disease and mortality outcomes. The risk of most events is highest in the early postinfection period. Individuals not requiring hospitalisation have increased risk of VTE, but not of other cardiovascular-specific outcomes. | |||||||||||||||||||||
34 | SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke | 2022-11-20 | https://doi.org/10.1016/j.pediatrneurol.2022.10.003 | MaryGlen J.VielleuxMD | https://www.sciencedirect.com/science/article/pii/S0887899422002107 | Prior COVID-19 infection, but not acute infection, is correlated with a risk for stroke in the pediatric population. | |||||||||||||||||||||
35 | Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis | 2022-12-01 | https://doi.org/10.1016/j.jacc.2022.09.049 | Lai F | https://www.jacc.org/doi/10.1016/j.jacc.2022.09.049 | This study found a significantly lower rate of mortality among individuals with myocarditis after mRNA vaccination compared with those with viral infection–related myocarditis.Adjusted analysis showed that the postvaccination myocarditis group had a 92% lower mortality risk (adjusted HR: 0.08; 95% CI: 0.01-0.57). | |||||||||||||||||||||
36 | Increased risk of acute myocardial infarction after COVID-19 recovery: A systematic review and meta-analysis | 2022-12-16 | https://doi.org/10.1016/j.ijcard.2022.12.032 | Marco Zuin | https://www.internationaljournalofcardiology.com/article/S0167-5273(22)01914-3/fulltext | The risk of acute myocardial infarction was 93% higher in COVID-19 recovered patients compared to the general population. Over a mean follow-up of 8.5 months, among COVID-19 recovered patients AMI occurred in 3.5 cases per 1.000 individuals compared to 2.02 cases per 1.000 individuals in the control cohort, defined as those who did not experience COVID-19 infection in the same period). | |||||||||||||||||||||
37 | Mid- and Long-Term Atrio-Ventricular Functional Changes in Children after Recovery from COVID-19 | 2022-12-26 | https://doi.org/10.3390/jcm12010186 | Jolanda Sabatino | https://www.mdpi.com/2077-0383/12/1/186 | Our study demonstrated for the first time the persistence of LV (left ventricular) myocardial deformation abnormalities in previously healthy children with an asymptomatic or mildly symptomatic (WHO stages 0 or 1) COVID-19 course. These findings imply that subclinical LV dysfunction may also be a typical characteristic of COVID-19 infection in children and are concerning given the predictive value of LV longitudinal strain in the general population. (Note: Studies find longitudinal strain is associated with long-term risk of cardiovascular morbidity and mortality.) | |||||||||||||||||||||
38 | Risk of incident heart failure after COVID-19 recovery: a systematic review and meta-analysis | 2022-12-27 | https://doi.org/10.1007/s10741-022-10292-0 | Marco Zuin | https://link.springer.com/article/10.1007/s10741-022-10292-0 | COVID-19 survivors had an additional 90% risk of developing HF (Heart Failure) after COVID-19 infection in the long-term period. | |||||||||||||||||||||
39 | One-year cardiovascular outcomes after coronavirus disease 2019: The cardiovascular COVID-19 registry | 2022-12-30 | https://doi.org/10.1371/journal.pone.0279333 | Luis Ortega-Paz | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279333 | At one year, there were no significant differences in the primary endpoint of CV death between the COVID-19 and control cohorts (1.4% vs. 0.8%; HRadj 1.28 [0.56–2.91]; p = 0.555), but there was a higher risk of all-cause death (17.8% vs. 4.0%; HRadj 2.82 [1.99–4.0]; p = 0.001). COVID-19 cohort had higher rates of ATE (arterial thrombotic events) (2.5% vs. 0.8%, HRadj 2.26 [1.02–4.99]; p = 0.044), VTE (venous thromboembolism) (3.7% vs. 0.4%, HRadj 9.33 [2.93–29.70]; p = 0.001), and serious cardiac arrhythmias (2.5% vs. 0.6%, HRadj 3.37 [1.35–8.46]; p = 0.010). | |||||||||||||||||||||
40 | Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome | 2023-01-01 | https://doi.org/10.1016/j.jtha.2022.10.013 | Adela Constantinescu-Bercu | https://www.jthjournal.org/article/S1538-7836(22)07182-3/fulltext | Post-COVID syndrome can lead to increased platelet recruitment and larger thrombi under flow. The median time of 23 months from symptom onset suggests potential long-term thrombogenicity. Our data show a significant increase in platelet binding on both collagen and anti-VWF A3 in patients with PCS compared with that in controls. | |||||||||||||||||||||
41 | Risks and burdens of incident dyslipidaemia in long COVID: a cohort study | 2023-01-06 | https://doi.org/10.1016/S2213-8587(22)00355-2 | Evan Xu, BA | https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00355-2/fulltext | Compared with the non-infected contemporary control group, those in the COVID-19 group had higher risks and burdens of incident dyslipidaemia, including total cholesterol greater than 200 mg/dL (hazard ratio [HR] 1·26), triglycerides greater than 150 mg/dL (1·27), LDL cholesterol greater than 130 mg/dL (1·24), and HDL cholesterol lower than 40 mg/dL (1·20). The risk of a composite of these abnormal lipid laboratory outcomes was 1·24 (95% CI 1·21–1·27). | |||||||||||||||||||||
42 | Cardiovascular Disease in Post-Acute COVID-19 Syndrome: A Comprehensive Review of Pathophysiology and Diagnosis Approach | 2023-01-13 | https://doi.org/10.31083%2Fj.rcm2401028 | PMC11270463 | Nuraini Yasmin Kusumawardhani | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270463/ | The COVID-19 pandemic is an ongoing catastrophic public health event with dire long-term consequences, as many COVID-19 survivors experience a novel syndrome designated as long COVID syndrome. This novel syndrome also involved the CV system and manifests in coronary artery disease, hypertension, arrhythmia, heart failure, venous thromboembolism, and POTS. | ||||||||||||||||||||
43 | Association of COVID-19 with short- and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank | 2023-01-19 | https://doi.org/10.1093/cvr/cvac195 | Eric Yuk Fai Wan | https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac195/6987834 | In the acute phase, patients with COVID-19 (n = 7584) were associated with a significantly higher short-term risk of CVD (cardiovascular disease) {hazard ratio (HR): 4.3} and all-cause mortality [HR: 81.1] than the contemporary (n = 75 790) controls (n = 75 774). Regarding the post-acute phase, patients with COVID-19 (n = 7139) persisted with a significantly higher risk of CVD in the long-term [HR: 1.4] and all-cause mortality [HR: 5.0] compared to the contemporary (n = 71 296) controls (n = 71 314). | |||||||||||||||||||||
44 | Clinical presentation and management strategies of cardiovascular autonomic dysfunction following a COVID-19 infection – a systematic review | 2023-01-24 | https://doi.org/10.1111/ene.15714 | Diogo Reis Carneiro | https://onlinelibrary.wiley.com/doi/10.1111/ene.15714 | There is evidence from the scientific literature about different types of cardiovascular autonomic dysfunction developing during and after COVID-19. Reflex syncope was the most common cardiovascular autonomic disorder in the acute phase (p=0.008), postural orthostatic tachycardia syndrome (POTS) the most frequent diagnosis in people with post-COVID-19 orthostatic complaints (p<0.001). Full recovery was more frequent in people with acute versus post-COVID-19 onset of cardiovascular autonomic disturbances (43% vs. 15%, p=0.002). | |||||||||||||||||||||
45 | Incidence of myocarditis among patients recovered from COVID-19 infection identified using cardiac magnetic resonance imaging | 2023-01-25 | https://doi.org/10.1093/eurheartj/ehac779.008 | R Tugade | https://academic.oup.com/eurheartj/article/44/Supplement_1/ehac779.008/7000570?login=false | Myocarditis is one of the cardiovascular complications among patients who recovered from COVID-19... Fifty-four percent (54%) of patients had positive conventional MRI findings indicative of myocarditis. Dyspnea, palpitations and chest discomfort were the most commonly reported symptoms in 29 (54%), 24 (44%) and 21 (39%) patients, respectively. Twenty-nine patients (54%) were observed with increased T2 signal or positive LGE (Late gadolinium enhancement, a predictor of adverse cardiovascular outcomes). | |||||||||||||||||||||
46 | Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis | 2023-01-29 | https://doi.org/10.3390/diagnostics13030491 | Abhigan Babu Shrestha | https://www.mdpi.com/2075-4418/13/3/491 | In our meta-analysis, the odds of developing myocarditis were around 5-fold, pericarditis was 1.5-fold, and cardiomyopathy was 2-fold in the post-COVID-19 phase... The odds of developing coronary vessel diseases such as angina (OR 1.6) and myocardial infarction (OR 1.6) were also significantly higher in long-COVID cases... the odds of developing thromboembolic changes such as deep vein thrombosis (OR 1.98), pulmonary embolism (OR 2.76), TIA (1.49), and stroke (OR 1.39) are also higher in post-COVID syndrome. | |||||||||||||||||||||
47 | Clinical outcomes of myocarditis after SARS-CoV-2 mRNA vaccination in four Nordic countries: population based cohort study | 2023-02-01 | 10.1136/bmjmed-2022-000373 | Anders Husby | https://bmjmedicine.bmj.com/content/2/1/e000373 | The relative risk of heart failure within 90 days was 0.56 (95% confidence interval 0.37 to 0.85) and 1.48 (0.86 to 2.54) for myocarditis associated with vaccination and covid-19 disease, respectively, compared with conventional myocarditis; the relative risk of death was 0.48 (0.21 to 1.09) and 2.35 (1.06 to 5.19), respectively. Among patients aged 12-39 years with no predisposing comorbidities, the relative risk of heart failure or death was markedly higher for myocarditis associated with covid-19 disease than for myocarditis associated with vaccination (relative risk 5.78, 1.84 to 18.20). | |||||||||||||||||||||
48 | Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection | 2023-02-01 | https://doi.org/10.1136/openhrt-2022-002241 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9950586/ | Adriana Roca-Fernandez | https://pubmed.ncbi.nlm.nih.gov/36822818/ | CMR (Cardiac MR) abnormalities (left entricular or right ventricular dysfunction/dilatation and/or abnormal T1mapping), occurred in one in five individuals with Long COVID at 6 months, persisting in over half of those at 12 months. Of individuals with Long COVID, 102/534 (19%) had CMR abnormalities at baseline; 71/102 had complete paired data at 12 months. Of those, 58% presented with ongoing CMR abnormalities at 12 months. | ||||||||||||||||||||
49 | Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease | 2023-02-15 | https://doi.org/10.3390/jcm12041536 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9959779/ | Julia Hanne Niebauer | https://pubmed.ncbi.nlm.nih.gov/36836071/ | Even 6 months after discharge, a majority fulfilled criteria for Long-COVID. While no associations between fatigue and cardiopulmonary abnormalities were found, exertional dyspnea correlated with impaired pulmonary function, reduced GLS (global longitudinal strain) and/or diastolic dysfunction. Magnetic resonance imaging revealed traces of pericardial effusion in 18% and signs of former pericarditis or myocarditis in 4%. Pulmonary function was impaired in 11%. | ||||||||||||||||||||
50 | Abnormal right ventricular echocardiographic findings in recovered patients associated with severe acute respiratory syndrome in COVID-19 | 2023-02-17 | https://doi.org/10.1111/echo.15538 | Leandro S. A. Barros MD | https://onlinelibrary.wiley.com/doi/10.1111/echo.15538 | SARS is a risk factor for abnormal RV echocardiographic findings in patients recovered from COVID-19. The frequency of RV echocardiographic changes in patients who had recovered from COVID-19 was 44.3%. RV systolic dysfunction was identified in 31.1%, followed by ventricular dilation in 14.7% and pulmonary hypertension in 9.8%. An association was observed between SARS and RV echocardiographic changes in recovered patients during outpatient follow-up (OR: 4.96; 95% CI: 1.37–17.9; p = 0.015). | |||||||||||||||||||||
51 | Cardiac manifestations in children with the multisystem inflammatory syndrome (MIS-C) associated with SARS-CoV-2 infection: Systematic review and meta-analysis | 2023-02-18 | https://doi.org/10.1002/rmv.2432 | Márcio Antonio Ferreira Arantes Junior | https://onlinelibrary.wiley.com/doi/10.1002/rmv.2432 | Study of children hospitalized with MIS-C: these children will have an increased cardiovascular risk with a greater chance of acute myocardial infarction, arrhythmias, or thrombosis will be essential for healthcare planning. The combined prevalence of myocarditis or pericarditis was 34.3% (95% CI: 25.0%–44.2%). The combined prevalence for echocardiogram anomalies was 40.8% (95% CI: 30.5%–51.5%), that of Kawasaki disease presentation was 14.8% (95% CI: 7.5%–23.7%), and that of coronary dilation was 15.2% (95% CI: 11.0%–19.8%). | |||||||||||||||||||||
52 | Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes | 2023-02-22 | https://doi.org/10.3389/fcell.2023.1110271 | Peng Zhang | https://www.frontiersin.org/articles/10.3389/fcell.2023.1110271/full | We found that the ectopic expression of S and ORF-9B subunits significantly impaired the contractile function and altered the metabolic profiles in human cardiomyocytes... Based on the transcriptomic analysis, both S and ORF-9B subunits dysregulated signaling pathways associated with metabolism and cardiomyopathy, including upregulated genes involved in HIF-signaling and downregulated genes involved in cholesterol biosynthetic processes. The ORF-9B subunit also enhanced glycolysis in the CMs. | |||||||||||||||||||||
53 | Orthostatic tachycardia after covid-19 | 2023-02-24 | https://doi.org/10.1136/bmj-2022-073488 | Ana B Espinosa-Gonzalez | https://www.bmj.com/content/380/bmj-2022-073488 | About 25% of long covid patients may have dysautonomia and 2-14% will develop orthostatic tachycardia (postural orthostatic tachycardia syndrome) six to eight months after infection. Dysautonomia in long covid typically affects young, previously healthy individuals (aged 15-45), with a female sex predominance (80%). | |||||||||||||||||||||
54 | CARDIAC COMPLICATIONS AMONG LONG COVID PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS | 2023-03-01 | https://doi.org/10.1016/S0735-1097(23)02559-7 | Joanna Lee | https://www.jacc.org/doi/10.1016/S0735-1097%2823%2902559-7 | Patients with long COVID have significantly higher odds of developing cardiac complications compared to those who do not. The unadjusted odds of cardiac complications in long COVID-19 were significantly higher (OR 2.35, p=0.01) with high heterogeneity (I2=91%). We performed sensitivity analysis by excluding study by Galloway et al to reduce the heterogeneity and the odds of cardiac complications remained same with moderate heterogeneity (OR 2.57, p=<0.001, I2=51%). | |||||||||||||||||||||
55 | One-Year Adverse Outcomes Among US Adults With Post–COVID-19 Condition vs Those Without COVID-19 in a Large Commercial Insurance Database | 2023-03-03 | doi:10.1001/jamahealthforum.2023.0010 | Andrea DeVries, PhD | https://jamanetwork.com/journals/jama-health-forum/fullarticle/2802095 | Adults with PCC (post–COVID-19 condition) experienced increased risks for a number of cardiovascular outcomes, such as ischemic stroke. During the 12-month follow-up period, 2.8% of the individuals with PCC vs 1.2% of the individuals without COVID-19 died, implying an excess death rate of 16.4 per 1000 individuals. | |||||||||||||||||||||
56 | SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19 | 2023-03-08 | https://doi.org/10.1371/journal.pone.0282151 | Daniel J. Clemens | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282151 | The SARS-CoV-2 spike protein can directly perturb both the cardiomyocyte’s repolarization reserve and intracellular calcium handling that may confer the intrinsic, mechanistic substrate for the increased risk of SCD observed during this COVID-19 pandemic. | |||||||||||||||||||||
57 | Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study | 2023-03-08 | https://doi.org/10.3390/jcm12062123 | Mario Podrug | https://www.mdpi.com/2077-0383/12/6/2123 | We found that various parameters of arterial stiffness and central hemodynamics respond simultaneously to the mild COVID-19 disease in predominantly healthy individuals. The detected responses to COVID-19 disease are not straightforward but rather deteriorate with the time since the onset of COVID-19 infection and age. Within the period of 2–3 months following infection, our models demonstrated a clinically significant progression of vascular impairment. | |||||||||||||||||||||
58 | How Does COVID-19 Affect the Heart? | 2023-03-10 | https://doi.org/10.1007/s11886-023-01841-6 | Lorenzo R. Sewanan | https://link.springer.com/article/10.1007/s11886-023-01841-6 | The high prevalences of microthrombi and inflammatory infiltrates in fatal COVID-19 raise the concern that recovered COVID-19 patients may have similar but subclinical cardiac pathology. Imaging and epidemiologic studies of recovered COVID-19 patients suggest that even mild illness confers increased risks of cardiac inflammation, cardiovascular disorders, and cardiovascular death. The ongoing evolution of SARS-CoV-2 variants and vast numbers of recovered COVID-19 patients portend a burgeoning global cardiovascular disease burden. | |||||||||||||||||||||
59 | Left ventricular global longitudinal strain as a parameter of mild myocardial dysfunction in athletes after COVID-19 | 2023-03-15 | https://doi.org/10.1101/2023.03.14.23287258 | Jana Schellenberg | https://www.medrxiv.org/content/10.1101/2023.03.14.23287258v1 | In a cohort of athletes at a median two months after COVID-19, significantly lower GLS (global longitudinal strain) and diastolic function were observed, suggesting mild myocardial dysfunction. There was a trend toward lower GLS in PCAt (positive COVID-19 test group) with subjectively perceived performance limitation (p=0.054). | |||||||||||||||||||||
60 | The potential role of SARS-CoV-2 infection in acute coronary syndrome and type 2 myocardial infarction (T2MI): Intertwining spread | 2023-03-17 | https://doi.org/10.1002/iid3.798 | Aseel Awad Alsaidan | https://onlinelibrary.wiley.com/doi/10.1002/iid3.798 | SARS-CoV-2 infection through hypercytokinemia, direct cardiomyocyte injury, and dysregulation of the renin-angiotensin system may aggravate underlying ACS (acute coronary syndrome) or cause new-onset T2MI (Secondary or type 2 myocardial infarction). As well, arrhythmias induced by anti-COVID-19 medications could worsen underlying ACS. | |||||||||||||||||||||
61 | Cardiovascular and Cerebral Vascular Health in Females with Post-Acute Sequelae of COVID-19 (PASC) | 2023-03-31 | https://doi.org/10.1152/ajpheart.00018.2023 | Damsara Nandadeva | https://journals.physiology.org/doi/abs/10.1152/ajpheart.00018.2023 | BP and central arterial stiffness are elevated in females with PASC, whereas peripheral and cerebral vascular function appear to be unaffected; effects that appear independent of symptom burden. | |||||||||||||||||||||
62 | Longitudinal Trends in Cardiovascular Risk Factor Profiles and Complications Among Patients Hospitalized for COVID-19 Infection: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry | 2023-04-05 | https://doi.org/10.1161/CIRCOUTCOMES.122.009652 | Eric J. Hall | https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.122.009652 | Despite a shifting risk factor profile toward a younger population with lower rates of established CVD (cardiovascular disease), the incidence of diagnosed cardiovascular complications of COVID increased from the onset of the pandemic through December 2021. All-cause mortality decreased during the initial months of the pandemic and thereafter remained consistently high through December 2021. | |||||||||||||||||||||
63 | Data-driven analysis to understand long COVID using electronic health records from the RECOVER initiative | 2023-04-07 | https://doi.org/10.1038/s41467-023-37653-z | Chengxi Zang | https://www.nature.com/articles/s41467-023-37653-z | We identified a broad list of diagnoses and medications which exhibited significantly higher incidence risk for patients 30–180 days after the laboratory-confirmed SARS-CoV-2 infection compared to non-infected patients. We identified more PASC diagnoses in NYC than in Florida regarding our screening criteria, and conditions including dementia, hair loss, pressure ulcers, pulmonary fibrosis, dyspnea, pulmonary embolism, chest pain, abnormal heartbeat, malaise, and fatigue, were replicated across both cohorts. | |||||||||||||||||||||
64 | Major adverse cardiovascular events are associated with necroptosis during severe COVID-19 | 2023-04-20 | https://doi.org/10.1186/s13054-023-04423-8 | Rosana Wiscovitch-Russo | https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04423-8 | SARS-CoV-2 identification in the systemic circulation is associated with MACE (major adverse cardiac events ) and necroptosis activity. The increased pMLKL and Troponin-I indicated the occurrence of necroptosis in the heart. | |||||||||||||||||||||
65 | SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection | 2023-04-24 | https://doi.org/10.1093/cei/uxad046 | Kerensa E Ward, MSc | https://academic.oup.com/cei/advance-article/doi/10.1093/cei/uxad046/7140487 | We find increased levels of DSG2 protein in sera from acute COVID-19 patients. Furthermore, we find that DSG2 (anti-desmoglein) autoantibody levels are increased significantly in convalescent sera following severe COVID-19 but not in hospitalised patients recovering from influenza infection or healthy controls. Levels of autoantibody in sera from patients with severe COVID-19 were comparable to levels in patients with non-COVID-19-associated cardiac disease. | |||||||||||||||||||||
66 | Long-term prognostic impact of subclinical myocardial dysfunction in patients recovered from COVID-19 | 2023-04-26 | https://doi.org/10.1111/echo.15575 | Francesco Cannata MD | https://onlinelibrary.wiley.com/doi/10.1111/echo.15575 | In patients recovered from COVID-19 pneumonia, a subclinical myocardial dysfunction is present in one-third of the whole population at 7-month follow-up and is associated with a higher risk of MACE (major adverse cardiovascular events) at long-term follow-up. | |||||||||||||||||||||
67 | COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research | 2023-04-30 | https://doi.org/10.1186/s43044-023-00359-0 | Sri Harsha Kanuri | https://tehj.springeropen.com/articles/10.1186/s43044-023-00359-0 | COVID-19-induced pathological derangements in the myocardium and systemic circulation in combination are accountable for instigation and persistence of this cardiac arrhythmia. Some patients presented with atrial fibrillation few months later after complete recovery from COVID-19 infections. These long haulers are known to harbor silent COVID-19 infections in the systemic tissues including myocardium. | |||||||||||||||||||||
68 | Changes in blood flow vortices inside the left ventricle in COVID-19 patients with intraventricular clot despite a normal coronary and myocardial motion | 2023-05-23 | https://doi.org/10.1007/s12574-023-00603-1 | Mersedeh Karvandi | https://link.springer.com/article/10.1007/s12574-023-00603-1 | Our results suggest that in some COVID-19 patients, cardiac wall motion is not satisfactorily able to circulate the blood fluid in normal directions and that, despite normal myocardium, changes in the directions of blood flow inside the left ventricle might lead to clots in different zones. This phenomenon may be related to changes in blood properties, such as viscosity. | |||||||||||||||||||||
69 | Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis | 2023-05-31 | https://doi.org/10.1093/ehjci/jead118 | Ahmed Ibrahim Ahmed | https://academic.oup.com/ehjcimaging/advance-article-abstract/doi/10.1093/ehjci/jead118/7186983?redirectedFrom=fulltext&login=false | Patients with prior COVID-19 had a statistically significant higher odds of Myocardial flow reserve (MFR) <2 (adjusted odds ratio 3.1, 95% confidence interval 2.8–4.25 P < 0.001). The proportion of cases with MFR <2 peaked 6–9 months from imaging with a statistically non-significant downtrend afterwards and was comparable across SARS-CoV-2 variants but increased with increasing severity of infection. | |||||||||||||||||||||
70 | Prevalence of coronary artery disease among COVID-19 patients: a systematic review and meta-analysis | 2023-06-01 | https://doi.org/10.1101/2023.06.01.23290768 | Naushaba Akhtar | https://www.medrxiv.org/content/10.1101/2023.06.01.23290768v1 | The burden of coronary artery disease has been considerable, varying with geography. The prevalence of coronary artery disease among COVID-19 patients was 15.24% (95% CI: 11.41% - 20.06%). The studies were highly heterogeneous... Europe reported the highest prevalence [21.70% (14.80% - 30.65%)], and Asia has the least prevalence [10.07% (6.55% - 15.19%)]. | |||||||||||||||||||||
71 | Prevalence of probable post-COVID cardiac sequelae and its health seeking behaviour among health care workers: A cross-sectional analytical study | 2023-06-14 | https://doi.org/10.1016/j.ijtb.2023.06.008 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10264162/ | Yamini Marimuthu | https://pubmed.ncbi.nlm.nih.gov/39890371/ | Around one out of ten individuals had experienced probable post-COVID cardiac sequelae, but only half of them got evaluated for it. The prevalence of probable post-COVID cardiac sequelae among health workers and medical students was 11.9% (95% CI: 8.76-15.7). Females, hypertensive individuals, and those who had moderate-severe disease during acute COVID-19 disease were at higher risk of developing probable post-COVID cardiac sequelae. | ||||||||||||||||||||
72 | Incidence and predictors of development of new onset hypertension post COVID-19 disease | 2023-06-14 | https://doi.org/10.1016/j.ihj.2023.06.002 | Pooja Vyas A | https://www.sciencedirect.com/science/article/pii/S0019483223001037 | We found that 32.3% of the population had new onset of hypertension at 1 year follow-up post-COVID-19 disease recovery. | |||||||||||||||||||||
73 | Risk of ischemic stroke in patients recovered from COVID-19 infection: A systematic review and meta-analysis | 2023-07-25 | https://doi.org/10.1177/23969873231190432 | Marco Zuin | https://journals.sagepub.com/doi/10.1177/23969873231190432 | Recovered COVID-19 patients presented a higher risk of ischemic stroke ((HR: 2.06, 95% CI: 1.75–2.41, p < 0.0001, I2 = 63.7%) compared to people who did not have COVID-19. COVID-19 patients hospitalized at the time of the infection have a subsequent higher risk of stroke during the follow-up compared to those non-hospitalized. | |||||||||||||||||||||
74 | Effects of COVID-19 Infection in Healthy Subjects on Cardiac Function and Biomarkers of Oxygen Transport, Blood Coagulation and Inflammation | 2023-07-25 | https://doi.org/10.3390/v15081623 | Nadezhda Gumanova | https://www.mdpi.com/1999-4915/15/8/1623 | LV filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by COVID-19 infection in healthy participants. The left ventricular mass index, mitral ratio of peak early to late diastolic filling velocity or flow velocity across the mitral valve, and deceleration time of early mitral inflow were decreased (p < 0.05) in IgG-SARS-positive participants versus those in IgG-SARS-negative participants according to multivariate logistic regression analysis. | |||||||||||||||||||||
75 | SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels | 2023-08-15 | https://doi.org/10.1101/2023.08.14.553245 | Natalia Eberhardt | https://www.biorxiv.org/content/10.1101/2023.08.14.553245v1 | Our data establish that SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, resulting in plaque inflammation that may promote acute CV complications and long-term risk for CV events. | |||||||||||||||||||||
76 | Echocardiographic Assessment in Patients Recovered from Acute COVID-19 Illness | 2023-08-15 | https://doi.org/10.3390/jcdd10080349 | Luke Stefani | https://www.mdpi.com/2308-3425/10/8/349 | Alterations in LV (left ventricular) and RV (right ventricular) strain were observed in both hospitalized and non-hospitalized patients. In the subset of COVID-19 patients without any co-morbidities (n = 30), LV GLS remained reduced compared to controls. Abnormal LV strain was evident in both hospitalized and non-hospitalized patients, suggesting that these changes are independent of the severity of COVID-19 infection at presentation. | |||||||||||||||||||||
77 | Incidence of New-Onset Hypertension Post–COVID-19: Comparison With Influenza | 2023-08-21 | https://doi.org/10.1161/HYPERTENSIONAHA.123.21174 | Vincent Zhang | https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.123.21174 | Incidence of new-onset persistent hypertension in patients with COVID-19 is higher than those with influenza, likely constituting a major health burden given the sheer number of patients with COVID-19. Hospitalized patients with COVID-19 were 2.23 ([95% CI, 1.48–3.54]; P<0.001) times and nonhospitalized patients with COVID-19 were 1.52 ([95% CI, 1.22–1.90]; P<0.01) times more likely to develop persistent hypertension than influenza counterparts. | |||||||||||||||||||||
78 | SARS-CoV-2 reinfection: Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease | 2023-09-01 | https://doi.org/10.1016/j.athplu.2023.06.002 | Petri T. Kovanen | https://www.sciencedirect.com/science/article/pii/S266708952300010X?via%3Dihub | Both the first infection and reinfection with SARS-CoV-2 increase cardiac event risk, particularly in vulnerable patients with cardiovascular risk factors and the accompanying systemic endothelial dysfunction. By worsening pre-existing endothelial dysfunction, both the first infection and reinfection with ensuing COVID-19 may turn the endothelium procoagulative and prothrombotic, and ultimately lead to local thrombus formation. | |||||||||||||||||||||
79 | Autonomic dysregulation in long-term patients suffering from Post-COVID-19 Syndrome assessed by heart rate variability | 2023-09-22 | https://doi.org/10.1038/s41598-023-42615-y | Frank C. Mooren | https://www.nature.com/articles/s41598-023-42615-y | PCS (Post COVID Syndrome) patients showed disturbed diurnal adjustment of HRV (heart rate variability), with impaired parasympathetic activity at night. Our data demonstrate persistent HRV alterations in PCS patients with long-term symptom duration, suggesting a sustained impairment of sympathovagal balance. Moreover, sympathetic overstimulation and diminished parasympathetic response in long-term PCS patients are comparable to findings in CAD (Coronary Artery Disease) patients. | |||||||||||||||||||||
80 | SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels | 2023-09-28 | https://doi.org/10.1038/s44161-023-00336-5 | Natalia Eberhardt | https://www.nature.com/articles/s44161-023-00336-5 | Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection... Our data establish that SARS-CoV-2 infects coronary vessels, inducing plaque inflammation that could trigger acute cardiovascular complications and increase the long-term cardiovascular risk. | |||||||||||||||||||||
81 | Prolonged platelet hyperactivity after COVID-19 infection | 2023-10-11 | https://doi.org/10.1111/bjh.19125 | Noriko Nara | https://onlinelibrary.wiley.com/doi/10.1111/bjh.19125 | Our results showed that platelet hyperactivity persisted for at least 40 days even after acute inflammation subsided in most patients with COVID-19, regardless of disease severity. Persistent platelet hyperactivity may contribute to thromboembolic complications in post-COVID-19 patients. | |||||||||||||||||||||
82 | Myocardial injury and related mortality in hospitalized patients with COVID-19 during the Omicron pandemic: new perspectives and insights | 2023-10-13 | https://doi.org/10.1016/j.virs.2023.10.005 | Wu He | https://www.sciencedirect.com/science/article/pii/S1995820X23001281?via%3Dihub | Myocardial injury accounted for 30.8% of the total patients with SARS-CoV-2 infection and was associated with higher in-hospital mortality than those without injury... our results showed that the proportion of cardiac muscle injuries was higher in patients infected with the Omicron variant. | |||||||||||||||||||||
83 | Baroreflex sensitivity is impaired in survivors of mild COVID-19 at 3–6 months of clinical recovery; association with carotid artery stiffness | 2023-10-31 | https://doi.org/10.14814/phy2.15845 | Prachi Srivastava | https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15845 | Fifty-seven survivors of mild COVID-19, with an age range of 22–66 years (27 females) participated at 3–6 months of recovering from the acute phase of RT-PCR positive COVID-19BRS (baroreflex sensitivity) was found to be significantly lower in the COVID survivor group for the systolic blood pressure-based sequences. The COVID survivor group showed significantly higher carotid β stiffness index, and pulse wave velocity. Impairment of BRS in the male survivors of mild COVID-19 at 3–6 months of clinical recovery shows association with carotid artery stiffness. | |||||||||||||||||||||
84 | Cardiovascular Follow-up of Patients Treated for MIS-C | 2023-11-15 | https://doi.org/10.1542/peds.2023-063002 | Dayna Zimmerman | https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2023-063002/195462/Cardiovascular-Follow-up-of-Patients-Treated-for?autologincheck=redirected | The high prevalence of abnormal findings on follow-up cardiac studies and lack of significant difference between patients with and without apparent myocardial injury during hospitalization suggests that all patients treated for MIS-C warrant cardiology follow-up. | |||||||||||||||||||||
85 | Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study | 2023-11-21 | https://doi.org/10.1093/ehjopen/oead120 | Ioannis Katsoularis | https://academic.oup.com/ehjopen/advance-article/doi/10.1093/ehjopen/oead120/7439882?login=false | The incidence rate ratio of atrial tachycardias, paroxysmal supraventricular tachycardias and bradyarrhythmias was significantly increased up to 60, 180 and 14 days after COVID-19, respectively. There is an increased risk of cardiac arrhythmias following COVID-19, and particularly increased in elderly vulnerable individuals, as well as in individuals with severe COVID-19. | |||||||||||||||||||||
86 | The effect of mild to moderate COVID-19 infection on the cardiorespiratory fitness of firefighters | 2023-11-30 | https://doi.org/10.3389/fpubh.2023.1308605 | Susanne D'Isabel | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1308605/full | Peak VO2 (maximum volume of oxygen consumption attainable during physical exertion) (ml·kg−1·min−1) declined 7.3% among firefighters an average of 110 days past reporting mild to moderate COVID-19 infection. This decrease has implications for the operational readiness and safety of firefighters. | |||||||||||||||||||||
87 | Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis | 2023-12-01 | https://doi.org/10.1016/j.autneu.2023.103132 | Shin Jie Yong | https://www.sciencedirect.com/science/article/abs/pii/S1566070223000619 | POTS (postural orthostatic tachycardia syndrome) was 2.12-fold more likely to occur in infected than uninfected individuals (RR = 2.12, 95 % CI: 1.71 to 2.62, P < 0.001). | |||||||||||||||||||||
88 | Clinical and electrocardiographic correlates of myocardial dysfunction after COVID-19 in nonhospitalised patients in long-term follow-up. Data from the polish long-covid cardiovascular study | 2023-12-19 | https://doi.org/10.1002/jmv.29331 | Joanna Kapusta | https://onlinelibrary.wiley.com/doi/10.1002/jmv.29331 | The study showed that myocardial damage after COVID-19 affects men more often and is independent of typical clinical factors and the severity of the disease course. The QRS fragmentation and arrhythmias observed in the ECG indicate the possibility of myocardial dysfunction in patients after COVID-19. | |||||||||||||||||||||
89 | High Cardiac Troponin Levels in Infants with Acute SARS-CoV-2 Infection: A Prospective Comparative study | 2023-12-21 | https://doi.org/10.1016/j.jpeds.2023.113876 | Andrea Lo Vecchio | https://www.sciencedirect.com/science/article/abs/pii/S0022347623007400 | Infants with acute SARS-CoV-2 infection may show a subclinical and transient alteration of myocardial injury markers, especially in the first months of life. hs-cTn levels normalized during follow-up and were not associated with cardiac functional impairment; nevertheless, long-term consequences are unknown and should be carefully followed. | |||||||||||||||||||||
90 | Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model | 2023-12-22 | https://doi.org/10.1016/j.isci.2023.108641 | Kozue Murata | https://www.sciencedirect.com/science/article/pii/S2589004223027189?via%3Dihub | Mild infections sustained viral presence without significant dysfunction for a month, indicating persistent infection. However, when exposed to hypoxic conditions mimicking ischemic heart diseases, cardiac function deteriorated alongside intracellular SARS-CoV-2 reactivation in cardiomyocytes and disrupted vascular network formation. This study demonstrates that SARS-CoV-2 persistently infects the heart opportunistically causing cardiac dysfunction triggered by detrimental stimuli such as ischemia, potentially predicting a post COVID-19 era heart failure pandemic. | |||||||||||||||||||||
91 | Association between Cardiovascular Disease Risk and long COVID-19: A Systematic Review and Meta-analysis | 2023-12-31 | https://doi.org/10.1101/2023.12.30.23300656 | Yunxia Huang | https://www.medrxiv.org/content/10.1101/2023.12.30.23300656v1 | Our meta-analysis revealed a pooled OR of 1.68 (95% CI 1.55-1.81) (I2 = 69.1%, p= 0.000) for the overall risk of cardiovascular outcomes, indicating an elevated risk of cardiovascular diseases in individuals affected by long COVID-19. Our meta-analysis substantiates that individuals afflicted with long COVID-19 face an elevated risk of developing cardiovascular diseases. | |||||||||||||||||||||
92 | Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden | 2024-01-02 | https://doi.org/10.1038/s41569-023-00962-3 | Artur Fedorowski | https://www.nature.com/articles/s41569-023-00962-3 | Cardiovascular autonomic dysfunction (CVAD), in particular postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia, are among the most frequent and distinct phenotypes of post-COVID-19 syndrome; one-third of highly symptomatic patients can be affected. As well as global circulatory disturbances, CVAD in post-COVID-19 syndrome can manifest as microvascular and endothelial dysfunction, with local symptoms such as headache, brain fog, chest pain, dyspnoea and peripheral circulatory symptoms, including skin discolouration, oedema, Raynaud-like phenomena, and heat and cold intolerance. | |||||||||||||||||||||
93 | 3D Holo-tomographic Mapping of COVID-19 Microclots in Blood to Assess Disease Severity | 2024-01-09 | https://doi.org/10.1021/cbmi.3c00126 | Talia Bergaglio | https://pubs.acs.org/doi/full/10.1021/cbmi.3c00126# | Fewer microclots and platelet aggregates were detected in the plasma of healthy controls compared to COVID-19 patients. We observed microclots in all COVID-19 plasma samples. However, only a few microclots were detected in plasma from healthy donors, suggesting that microclotting is a salient feature of COVID-19. | |||||||||||||||||||||
94 | Longitudinal strain and myocardial work in symptomatic patients having recovered from COVID-19 and possible associations with the severity of the disease | 2024-01-26 | https://doi.org/10.1007/s10554-023-03042-2 | Luciana Bartolomei Orru D’Ávila | https://link.springer.com/article/10.1007/s10554-023-03042-2 | In our study with long COVID-19 individuals, despite having a similar LVGLS (left ventricle global longitudinal strain), patients had subclinical LV (left ventricular) dysfunction, demonstrated only by an increase in GWW (Global wasted work) and a decrease in GWE (global work efficiency). | |||||||||||||||||||||
95 | Increased risk of new-onset cardiovascular disease after COVID-19: A systematic review and meta-analysis of 14 cohorts | 2024-02-01 | https://doi.org/10.1002/rmv.2518 | Mingyao Sun | https://onlinelibrary.wiley.com/doi/10.1002/rmv.2518 | The results showed a 2.42 times higher risk of any CVD (cardiovascular disease), a 95% higher risk of MACE (major adverse cardiovascular events), a 61% higher risk of arrhythmias, a 71% higher risk of heart failure, a 5 times higher risk of myocarditis, and a 2.49 times higher risk of thrombotic events associated with COVID-19. | |||||||||||||||||||||
96 | Endothelial dysfunction and cardiovascular risk in post-COVID-19 patients after 6- and 12-months SARS-CoV-2 infection | 2024-02-07 | https://doi.org/10.1007/s15010-024-02173-5 | Paula Poyatos | https://link.springer.com/article/10.1007/s15010-024-02173-5 | These findings highlight the presence of vascular sequela that last up to 6- and 12-months post-infection and point out the need for preventive measures and patient follow-up. Post-COVID-19 patients showed a significant downregulation of angiogenesis-related proteins compared to controls indicating a clear endothelial injury. Troponin, NT-proBNP and ferritin levels, markers of cardiovascular risk and inflammation, remained elevated up to 12-months post-infection. | |||||||||||||||||||||
97 | Echocardiographic Strain Evaluation Shows Persistent Echocardiographic Changes at 1 Year after Diagnosis of Multisystem Inflammatory Syndrome in Children | 2024-03-05 | https://doi.org/10.3390/children11030308 | Jihye You | https://www.mdpi.com/2227-9067/11/3/308# | Persistent cardiac alterations were observed in patients with MIS-C, particularly in both ventricular functions. At 1-year follow-up, the reduced LVEF in the apical 4-chamber, overall longitudinal strain in the apical 4-chamber, and GLS persisted. However, the right ventricular free wall and global strain remained diminished compared with those in the control group. | |||||||||||||||||||||
98 | Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study | 2024-03-06 | https://doi.org/10.1007/s00431-024-05503-9 | A. B. Delogu | https://link.springer.com/article/10.1007/s00431-024-05503-9 | Data analysis showed that pediatric patients with long COVID had significant changes in HRV (Heart rate variability) variables compared to healthy controls.These findings suggest that pediatric patients with long COVID have an imbalance of cardiac autonomic function toward a relative predominance of parasympathetic tone, as already reported in adult patients with long COVID. | |||||||||||||||||||||
99 | Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study | 2024-03-11 | https://doi.org/10.1038/s41467-024-46497-0 | Genevieve I. Cezard | https://www.nature.com/articles/s41467-024-46497-0 | We showed that the incidence of each arterial thrombotic, venous thrombotic and other cardiovascular outcomes was substantially elevated during weeks 1-4 after COVID-19, compared with before or without COVID-19, but less markedly elevated in time periods beyond week 4. | |||||||||||||||||||||
100 | The role of COVID-19 vaccines in preventing post-COVID-19 thromboembolic and cardiovascular complications | 2024-03-12 | https://doi.org/10.1136/heartjnl-2023-323483 | Núria Mercadé-Besora | https://heart.bmj.com/content/early/2024/01/24/heartjnl-2023-323483 | COVID-19 vaccination reduced the risk of post-COVID-19 cardiac and thromboembolic outcomes. These effects were more pronounced for acute COVID-19 outcomes, consistent with known reductions in disease severity following breakthrough versus unvaccinated SARS-CoV-2 infection. Vaccination was associated with reduced risks of acute (30-day) and post-acute COVID-19 VTE, ATE and HF: for example, meta-analytic sHR of 0.22 (95% CI 0.17 to 0.29), 0.53 (0.44 to 0.63) and 0.45 (0.38 to 0.53), respectively, for 0–30 days after SARS-CoV-2 infection, while in the 91–180 days sHR were 0.53 (0.40 to 0.70), 0.72 (0.58 to 0.88) and 0.61 (0.51 to 0.73), respectively. | |||||||||||||||||||||
101 | Persistent increase of cardiovascular and cerebrovascular events in COVID-19 patients: a 3-year population-based analysis | 2024-03-19 | https://doi.org/10.1093/cvr/cvae049 | Allegra Battistoni | https://academic.oup.com/cardiovascres/article-abstract/120/6/623/7631430?login=false | The proportion of individuals with a new diagnosis of major adverse cardiovascular and cerebrovascular events was higher in the 2020–22 COVID-19 group than in the 2017–19 COMEGEN propensity score-matched comparator, with an odds ratio of 1.73 (95% confidence interval: 1.53–1.94; P < 0.001). All major adverse cardiovascular and cerebrovascular events considered showed a significantly higher risk in COVID-19 individuals. Incidence calculated for each 6-month period after the diagnosis of COVID-19 in our population was the highest in the first year (1.39% and 1.45%, respectively), although it remained significantly higher than in the COVID-19-free patients throughout the 3 years. | |||||||||||||||||||||
102 | Right heart overload – possible long-term sequelae of Covid-19: a narrative review | 2024-03-27 | https://doi.org/10.34119/bjhrv7n2-210 | Mariana da Costa Rocha | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/68387 | SARS-CoV2 creates a pro-thrombotic state through direct endothelial damage and a cytokine storm, affecting the lung, among other organs, leading to hypoxia and a rise in vascular resistance. Increased vascular resistance makes patients prone to cardiac stress, with a known association with right heart failure, among other insults to the heart. This condition affects both outpatients and inpatients, hypertension being a significant risk factor. | |||||||||||||||||||||
103 | Predictors and Clinical Significance of Myocardial Injury in Elderly Patients Under the COVID-19 Pandemic | 2024-03-27 | https://doi.org/10.2147/IJGM.S458365 | You Zhou | https://www.dovepress.com/predictors-and-clinical-significance-of-myocardial-injury-in-elderly-p-peer-reviewed-fulltext-article-IJGM | Myocardial injury was a common phenomenon and prognostic predictor in elder patients after SARS-CoV-2 infection. Predictors of myocardial injury included age (per 5-year increase), hypertension, vaccination, creatine, and neutrophil-to-lymphocyte ratio.Vaccination was shown to be the only protective factor of myocardial injury in older patients infected by the omicron variant of SARS-Cov-2. | |||||||||||||||||||||
104 | Patients with COVID-19 Infection and Stroke have Higher than Expected Mortality, Regardless of the Primary Presentation | 2024-03-30 | https://doi.org/10.1101/2024.03.29.24305101 | Jintong Liu | https://www.medrxiv.org/content/10.1101/2024.03.29.24305101v1 | We retrospectively reviewed and characterized all patients who presented to a single, quaternary medical center between March and December 2020. In the early pandemic, patients with COVID-19 infection and stroke had a higher mortality rate compared to COVID-19 negative patients with stroke. Among patients with both COVID-19 and stroke, patients presenting with COVID-19 first had worse outcomes than patients presenting with stroke first. | |||||||||||||||||||||
105 | Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2 | 2024-04-01 | https://doi.org/10.1016/j.mib.2024.102437 | Melina Tangos | https://www.sciencedirect.com/science/article/pii/S1369527424000134 | An infection with SARS-CoV-2 has the potential to manifest a diverse set of cardiovascular health problems, including myocardial tissue damage, arrhythmia, myocarditis, and pericarditis. Evidence is pointing toward prolonged COVID symptoms with cardiac involvement in some individuals, independent of infection severity. | |||||||||||||||||||||
106 | High prevalence of cardiac post-acute sequelae in patients recovered from Covid-19. Results from the ARCA post-COVID study | 2024-04-05 | https://doi.org/10.1016/j.ijcrp.2024.200267 | Valeria Antoncecchi | https://www.sciencedirect.com/science/article/pii/S2772487524000321 | NCA (new cardiac alterations) were found in 138 patients (27.49%): among them 60 cases (11.95%) of pericardial effusion. the prevalence of NCA in patients who recovered from COVID-19 is high and constant since the beginning of the pandemic. More than 6 months after the SARS-CoV2 infection, 77% of patients were still symptomatic, regardless of hospitalization or home treatment. The most frequent symptoms were dyspnoea, weakness, palpitations, fatigue, and anxiety/depression, with a prevalence greater than 10%. | |||||||||||||||||||||
107 | THE ELECTROCARDIOGRAPHIC CHANGES IN PATIENTS WITH VIRAL RESPIRATORY INFECTION IN SARS COV 19 VERSUS OTHER RESPIRATORY VIRUSES A SINGLE CENTER RETROSPECTIVE COHORT | 2024-04-05 | https://doi.org/10.1016/S0735-1097(24)02110-7 | Reihaneh C. Moghadam | https://www.jacc.org/doi/full/10.1016/S0735-1097%2824%2902110-7 | This comparative study of 553 patients with RVI showed a statistically significant increase in ischemic findings and arrhythmias in patients with COV vs. non-COV infections. Pertinent EKG findings included 38.6% new ischemic ABNLs in COV-G (positive for SARS-CoV-2) vs. 25.6% in non-COV-G (non-COV-G including Flu-A, Flu-B, Corona OC43, Corona HKU1, Corona NL63, hMPV, RSV, or RVs) in Pts with no underlying ischemic EKG ABNLs, 38.7% new rhythm ABNLs in COV-G vs. 25.9% in non-CoV-G in Pts without underlying rhythm abnormality in prior EKGs. | |||||||||||||||||||||
108 | Risk of major adverse cardiovascular events after SARS-CoV-2 infection in British Columbia: a population-based study | 2024-04-24 | https://doi.org/10.1016/j.amjmed.2024.04.010 | Héctor Alexander Velásquez García | https://www.sciencedirect.com/science/article/abs/pii/S0002934324002377 | SARS-CoV-2 infection was associated with higher cardiovascular risk with graded increase across the acute COVID-19 severity. The risk of major adverse cardiovascular events was higher in the exposed (adjusted HR [aHR]:1·34; 95%CI:1·22-1·46), with greater risk observed in those who were hospitalized (aHR:3·81; 95%CI:3·12-4·65) or required ICU admission (aHR:6·25; 95%CI:4·59-8·52) compared to the unexposed group. The fraction of cardiovascular events attributable to SARS-CoV-2 was 7·04% (95%CI:4·67-9·41%). | |||||||||||||||||||||
109 | Persistence of SARS-CoV-2 colonization and high expression of inflammatory factors in cardiac tissue 6 months after COVID-19 recovery: a prospective cohort study | 2024-04-30 | https://doi.org/10.21037/cdt-23-381 | Sanjiu Yu | https://cdt.amegroups.org/article/view/123848/html | Our research suggests that certain COVID-19-recovered patients have persistent colonization of SARS-CoV-2 in their cardiac tissue, accompanied by a local increase in inflammatory factors. In four of nine patients, SARS-CoV-2 RNA was detected in their LA tissue, indicating viral colonization. Among the four positive cases, the IL-6 and IL-1β relative expression levels in the LA tissue of one patient were increased approximately 55- and 110-fold, respectively, compared to those of SARS-CoV-2 (−) patients. | |||||||||||||||||||||
110 | Post-Covid Conditions and their Effects on the Cardiovascular System | 2024-05-01 | https://doi.org/10.7417/ct.2024.5056 | M Osadchuk | https://pubmed.ncbi.nlm.nih.gov/38767072/ | Cardiac screening results in individuals with COVID-19 reveal a significant prevalence of serious heart problems, affecting over half of the patients. By the 60th day, a reduction in symptoms by 5-10% was noted, and by the 90th day, a decrease in activity by 25-35% was observed. Patients aged 40-60 years exhibited the highest percentage of cardiovascular diseases (75%). | |||||||||||||||||||||
111 | Evidence Circulating Microclots and Activated Platelets Contribute to Hyperinflammation Within Pediatric Post Acute Sequala of COVID | 2024-05-01 | https://doi.org/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A2247 | Y.K. Okuducu | https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A2247 | We discovered evidence that children with PASC generate circulating microclots, activated platelets, and increased levels of clotting-related proteins. We showed that children with MIS-C and Long COVID contained many microclots within their plasma, a finding absent in healthy children. | |||||||||||||||||||||
112 | Cardiopulmonary Exercise Testing in Children With Long COVID: A Case-controlled Study | 2024-05-07 | https://doi.org/10.1097/INF.0000000000004371 | Baldi, Fabiana | https://journals.lww.com/pidj/fulltext/9900/cardiopulmonary_exercise_testing_in_children_with.849.aspx | Overall, 90.2% of LC patients (55 of 61) had a pathologic test vs 10.3% (3/29) of the healthy control. Compared with healthy controls, children with LC have objective impaired functional capacity (expressed by a low VO2 peak), signs of deconditioning and cardiogenic inefficiency when assessed with CPET. | |||||||||||||||||||||
113 | Evaluation of blood pressure variation in recovered COVID-19 patients at one-year follow-up: a retrospective cohort study | 2024-05-07 | https://doi.org/10.1186/s12872-024-03916-w | Pouria Azami | https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-024-03916-w#citeas | Our findings suggest a potential association between COVID-19 and increased systolic and diastolic BP in non-hospitalized patients, with a notable proportion of participants experiencing new-onset or exacerbated hypertension. COVID-19 raised systolic and diastolic BP in the long term in non-hospitalized patients, with over one-sixth developing new-onset or exacerbated hypertension. | |||||||||||||||||||||
114 | Long-term Effects of COVID-19 on Vascular Parameters—A Prospective Longitudinal Ultrasound Clinical Study | 2024-05-10 | https://doi.org/10.1177/15443167231210357 | James Chen | https://journals.sagepub.com/doi/10.1177/15443167231210357 | There were differences in intima-media lumen thickness (IMT), arterial velocities, and inflammatory markers in post-COVID-19 patients. Median intima-media thickness (IMT) was increased in mild/asymptomatic (0.80 mm) and severe/critical (0.90 mm) groups when compared with controls (0.60 mm). In the asymptomatic/mild group, 6-month median IMT (0.88 mm) was increased, compared with the 3-month group (0.75 mm). | |||||||||||||||||||||
115 | Long-term cardiovascular disease outcomes in non-hospitalized medicare beneficiaries diagnosed with COVID-19: Population-based matched cohort study | 2024-05-14 | https://doi.org/10.1371/journal.pone.0302593 | Quanhe Yang | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0302593 | COVID-19 showed initial stronger effects on all-cause mortality, hospitalization and 12 incident CVD outcomes with adjusted HRs in 0–3 months ranging from 1.05 (95% CI 1.01–1.09) for mortality to 2.55 (2.26–2.87) for pulmonary embolism. The effects of COVID-19 on outcomes reduced significantly after 3-month follow-up. Risk of mortality, acute myocardial infarction, cardiomyopathy, deep vein thrombosis, and pulmonary embolism returned to baseline after 6-month follow-up. | |||||||||||||||||||||
116 | Post-Acute Cardiovascular Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Project | 2024-05-15 | https://doi.org/10.1101/2024.05.14.24307380 | Bingyu Zhang | https://www.medrxiv.org/content/10.1101/2024.05.14.24307380v1 | Patients with CHD (Congenital Heart Defects)) post-SARS-CoV-2 infection showed increased risks of any cardiovascular outcome (RR, 1.63). Those without CHDs also experienced heightened cardiovascular risks after SARS-CoV-2 infection (RR, 1.63), covering 14 of 18 conditions in hypertension, arrhythmias, inflammatory heart disease, other cardiac disorders, thrombotic disorders, and cardiovascular-related symptoms. Both children with and without CHDs showed increased risks for a variety of cardiovascular outcomes after SARS-CoV-2 infection, underscoring the need for targeted monitoring and management in the post-acute phase. | |||||||||||||||||||||
117 | Long COVID and cardiovascular disease: a prospective cohort study | 2024-05-27 | https://doi.org/10.1136/openhrt-2024-002662 | Claire Alexandra Lawson | https://openheart.bmj.com/content/11/1/e002662 | Full recovery was significantly lower at 12 months in patients with CVD (cardiovasular disease) (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. | |||||||||||||||||||||
118 | The Effect of COVID-19 on Cardiovascular Diseases and the Need for Beta-Blocker Dose Modification | 2024-06-12 | https://doi.org/10.12775/JEHS.2024.74.51789 | Tomasz Jędrasek | https://apcz.umk.pl/JEHS/article/view/51789 | Patients with coronary artery diseases, who suffered from COVID-19, need to start or intensify treatment with beta-blockers and are more likely to develop long-term complications after recovery. Patients with preexisting CVD should be closely monitored during and after recovery from SARS-CoV-2 infection due to the higher risk of complications and the potential need for modifications in the treatment of chronic diseases. | |||||||||||||||||||||
119 | Pro-inflammatory cytokines are elevated two-years after acute severe COVID-19: a pre-vaccine, two-years, five-point longitudinal assessment of individuals with Long COVID | 2024-06-13 | https://doi.org/10.1093/eurjpc/zwae175.289 | C Luz Goulart | https://academic.oup.com/eurjpc/article/31/Supplement_1/zwae175.289/7692407?login=false | Even after more two years of COVID-19 infection the cytokine profile from this evaluation showed substantially elevated levels of IL-1β and TNF-α in participants with PASC, which could ultimately lead to new or worsening cardiovascular problems in this population. Regarding the prevalence of Long covid after 2 years of primary infection, 51/80 (63%) reported having remained with one or more symptoms.The longitudinal assessment of cytokine levels among participants showed significantly higher levels of IL-1β between D1 and D120 (p<0.0001); D1 and D720 (p<0.0001). In relation to TNF-α on D7 and D720 (p<0.001). | |||||||||||||||||||||
120 | Pathogenic mechanisms of cardiovascular damage in COVID-19 | 2024-06-19 | https://doi.org/10.1186/s10020-024-00855-2 | Hong-Hua Shao | https://molmed.biomedcentral.com/articles/10.1186/s10020-024-00855-2 | Cardiovascular damage in COVID-19 patients is common and portends a worse prognosis. The most common cardiovascular damage was myocarditis and pericarditis, hypertension, arrhythmia, myocardial injury and heart failure, coronary heart disease, stress cardiomyopathy, ischemic stroke, blood coagulation abnormalities, and dyslipidemia. | |||||||||||||||||||||
121 | Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection | 2024-06-20 | https://doi.org/10.1016/j.csbj.2024.06.024 | C Tintore | https://www.sciencedirect.com/science/article/pii/S2001037024002125 | In the first 3 months of follow-up, SARS-CoV-2 positive individuals had a higher risk of mortality and of all cardiovascular events. From 4-12 months, there was increased risk of mortality in SARS-CoV-2 positive individuals overall, of heart failure in SARS-CoV-2 positive females (HR= 1.26 [1.11-1.42]), and of arrhythmias and thrombosis in SARS-CoV-2 positive males (HR= 1.29 [1.14-1.47] and HR= 1.35 [1.03-1.77], respectively). | |||||||||||||||||||||
122 | Recovery from Severe COVID-19 Is an Independent Predictor of Electrocardiographic Abnormal P-Wave Axis | 2024-06-22 | https://doi.org/10.3390/diagnostics14131326 | Mücahid Yılmaz | https://www.mdpi.com/2075-4418/14/13/1326 | Individuals who have recovered from severe COVID-19 have shown an increased prevalence of aPwa. Abnormal P-wave axis (aPwa) have been correlated with an increased risk of supraventricular arrhythmias. | |||||||||||||||||||||
123 | Cardiovascular complications in the course of COVID-19 - lessons learned and implications for the future care of patients with viral respiratory diseases: Data from a single center retrospective observational study | 2024-06-29 | https://doi.org/10.1016/j.hrtlng.2024.06.009 | Dominika Krogulec | https://www.sciencedirect.com/science/article/pii/S0147956324001171 | Cardiovascular events are common and can cause significant clinical deterioration during the course of COVID-19. The risk of cardiovascular complications was especially pronounced in patients with older age, pre-existing cardiovascular disease and more sever pneumonia at presentation to care. | |||||||||||||||||||||
124 | Trends in Sudden Cardiac Death in Pilots: A Post COVID-19 Challenging Crisis of Global Perspectives (2011-2023) | 2024-07-01 | https://doi.org/10.1101/2024.06.29.24309708 | Julian Yin Vieira Borges | https://www.medrxiv.org/content/10.1101/2024.06.29.24309708v1 | Pilots who had been infected with COVID-19 had a 1.8 times higher risk of SCD (Sudden Cardiac Death) compared to those who had not been infected (RR: 1.8, 95% CI: 1.3-2.5) (16). Three studies examined the association between COVID-19 vaccination and the risk of myocarditis, a condition linked to SCD. The pooled analysis found no significant increase in the risk of myocarditis among vaccinated pilots compared to unvaccinated pilots (RR: 1.2, 95% CI: 0.8-1.8) | |||||||||||||||||||||
125 | Exploring the underlying molecular mechanisms of acute myocardial infarction after SARS-CoV-2 infection | 2024-07-01 | https://doi.org/10.1016/j.ahjo.2024.100417 | Enrui Xie | https://www.sciencedirect.com/science/article/pii/S2666602224000600 | our research revealed that a highly activated inflammatory response in patients with COVID-19 might be a crucial factor for susceptibility to AMI (acute myocardial infarction). | |||||||||||||||||||||
126 | Cardiovascular disease risk after a SARS-CoV-2 infection: a systematic review and meta-analysis | 2024-07-04 | https://doi.org/10.1016/j.jinf.2024.106215 | Karla Romero Starke | https://www.sciencedirect.com/science/article/pii/S016344532400149X | Pooled analysis show that for PE (pulmonary embolism), the risks were still doubled up to 4.5 months post-infection, and were still increased six to seven months after infection. For MI (myocardial infarction), a doubling of the risk was observed one month after infection, and an increasedrisk was still observed at least three months after infection. Results for IS (ischemic stroke) depict a doubling of the risk 1.5 months post-infection. After nine months, the risk remained and was still statistically significant. | |||||||||||||||||||||
127 | A comprehensive review on the association and prevention of long-term COVID-induced heart failure: A Review | 2024-07-05 | https://doi.org/10.1097/MD.0000000000038736 | Ren, Zhangqing | https://journals.lww.com/md-journal/fulltext/2024/07050/a_comprehensive_review_on_the_association_and.47.aspx | Research indicates that COVID-19, beyond its impact on the respiratory system, has significant effects on the cardiovascular system, leading to myocardial injuries, abnormal inflammatory responses, and thrombosis formation. | |||||||||||||||||||||
128 | SARS-CoV-2 S Protein Reduces Cytoprotective Defenses and Promotes Human Endothelial Cell Senescence | 2024-07-05 | https://doi.org/10.14336/ad.2024.0405 | Alicia Villacampa | https://pubmed.ncbi.nlm.nih.gov/39012668/ | Premature vascular aging and endothelial cell senescence are major risk factors for cardiovascular diseases and atherothrombotic disturbances, which are main complications of both acute and long COVID-19. In primary cultures of human umbilical vein endothelial cells (HUVEC), SARS-CoV-2 S protein enhanced in a concentration-dependent manner the cellular content of senescence and DNA damage response markers (senescence-associated-β galactosidase, γH2AX), as well as growth-arrest effectors (p53, p21, p16). In parallel, the S protein reduced the availability of cytoprotective proteins, such as the anti-aging protein klotho, Nrf2 or heme oxygenase-1, and caused functional harm by impairing ex vivo endothelial-dependent vasorelaxation in murine microvessels. | |||||||||||||||||||||
129 | Sex Modifies the Effect of COVID-19 on Arterial Elasticity | 2024-07-06 | https://doi.org/10.3390/v16071089 | Jared C. Durieux | https://www.mdpi.com/1999-4915/16/7/1089 | Estimated differences in augmentation index (AI) between COVID− (0.9 ± 17.2) and COVID+ (8.4 ± 15.7; p = 0.001) and between female and male sex (12.9 ± 1.9; p < .0001) were observed. Among COVID+ with PASC, the average AI (10.5 ± 1.6) was 9.7 units higher than COVID− (p < .0001) and 6.2 units higher compared to COVID+ with no PASC (p = 0.03). | |||||||||||||||||||||
130 | The Characteristics of Coronary Artery Lesions in COVID-19 Infected Patients with Coronary Artery Disease:An Optical Coherence Tomography Study | 2024-07-14 | https://doi.org/10.1016/j.amjcard.2024.07.008 | Shan-Shan Ji | https://www.sciencedirect.com/science/article/abs/pii/S0002914924005149 | OCT demonstrated that COVID-19 infection is associated with coronary pathological changes such as more plaque ruptures, erosions, and fibrosis as well as diffuse lesions. Further, COVID-19 infection is associated with the higher propensity for acute coronary events and the higher risk of MACE (major adverse cardiac events) in CAD (coronary artery disease) patients. | |||||||||||||||||||||
131 | Short-term and long-term stroke risk following SARS-CoV-2 infection in relation to disease severity: a Danish national cohort study | 2024-07-16 | https://doi.org/10.1136/bmjopen-2023-083171 | Camilla Schade Skov | https://bmjopen.bmj.com/content/14/7/e083171 | SARS-CoV-2 infection is associated with increased stroke risk. A positive SARS-CoV-2 test was associated with an SHR of 3.32 overall for stroke compared with test negative in the acute phase. In the postinfection period, the risk of stroke remained increased in individuals hospitalised during the acute phase (SHR 1.85). | |||||||||||||||||||||
132 | Quantifying the impact of post-acute sequelae of coronavirus on the cardiopulmonary endurance of athletes | 2024-07-17 | https://doi.org/10.1002/pul2.12413 | Daniel Lubarsky | https://onlinelibrary.wiley.com/doi/10.1002/pul2.12413 | Based on self-reported data, subjects endorsed a median decrease of 27% in cardiopulmonary endurance levels compared with 0% in controls (p = 0.0019). PASC subjects exercised less hours and had worse self-reported health as compared with controls. PASC subjects also had significantly worse Modified Oslo, Dyspnea, and EQ-5D-5L scores. Of the 32 PASC patients, 10 (31%) reported a complete inability to engage in any cardiovascular endurance exercise at 3 months. PASC leads to a significant, quantifiable decrease in cardiopulmonary health and endurance. | |||||||||||||||||||||
133 | COVID-19 in the Initiation and Progression of Atherosclerosis: Pathophysiology During and Beyond the Acute Phase | 2024-07-17 | https://doi.org/10.1016/j.jacadv.2024.101107 | Vignesh Chidambaram | https://www.sciencedirect.com/science/article/pii/S2772963X24003016 | SARS-CoV-2 infection can markedly influence the initiation and progression of atherosclerotic lesions. | |||||||||||||||||||||
134 | Long-term effects of COVID-19 on endothelial function, arterial stiffness, and blood pressure in college students: a pre-post-controlled study | 2024-07-27 | https://doi.org/10.1186/s12879-024-09646-w | Jianwei Peng | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09646-w | Our study demonstrated that COVID-19 has long-term detrimental effects on vascular function in college students. However, arterial stiffness tends to improve over time, while BP may exhibit the opposite trend. Our results showed that FMD (Brachial artery flow-mediated dilation) was significantly impaired after COVID-19 infection (p < 0.001), while cfPWV (carotid-femoral pulse wave velocity) and systolic blood pressure (SBP) were significantly increased (p < 0.05). | |||||||||||||||||||||
135 | COVID-19 related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac MRI abnormalities | 2024-07-29 | https://doi.org/10.1093/cvr/cvae159 | Andrej Ćorović | https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae159/7723296?login=false | COVID-19 related cardiac injury in symptomatic patients with non-ischaemic myocarditis-like MRI abnormalities is associated with immune dysregulation, including decreased peripheral CD8 TEM cells and increased CCL7, persisting long after the initial infection. | |||||||||||||||||||||
136 | SARS-CoV-2 spike protein acts as a β-adrenergic receptor agonist: A potential mechanism for cardiac sequelae of long COVID | 2024-07-29 | https://doi.org/10.1111/joim.20000 | Xiangning Deng | https://onlinelibrary.wiley.com/doi/10.1111/joim.20000 | Severe acute respiratory syndrome-coronavirus-2 spike proteins act as an allosteric β-AR agonist, leading to cardiac β-AR hyperactivity, thus contributing to PASC-CVS (post-acute sequelae of coronavirus disease-19-cardiovascular syndrome). | |||||||||||||||||||||
137 | SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo | 2024-08-02 | https://doi.org/10.1186/s13578-024-01280-y | Bobo Wing-Yee Mok | https://pubmed.ncbi.nlm.nih.gov/39095802/ | Omicron BA.2, which is generally thought to cause mild disease, can damage CMs (cardiomyocytes) in vitro and in vivo. Omicron BA.2 most efficiently infected and injured CMs in vitro and in vivo, and induced expression changes consistent with increased cardiac dysfunction, compared to other variants tested. | |||||||||||||||||||||
138 | The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease | 2024-08-08 | https://doi.org/10.3390/biom14080965 | Hidekatsu Yanai | https://www.mdpi.com/2218-273X/14/8/965 | we show a significant association of endothelial dysfunction with the development of long COVID-19 and show that biomarkers for endothelial dysfunction in patients with long COVID-19 are also crucial players in the development of ASCVD (atherosclerotic cardiovascular disease). The COVID-19 pandemic created a great number of long COVID-19 patients. Endothelial dysfunction in long COVID-19 can induce widespread problems of CKD (chronic kidney disease), CAD (coronary artery disease), HF (heart failure), and ischemic stroke. | |||||||||||||||||||||
139 | Clinical utility of ambulatory ECG monitoring and 2D-ventricular strain for evaluation of post-COVID-19 ventricular arrhythmia | 2024-08-16 | https://doi.org/10.1186/s12872-024-03982-0 | Rehab M. Hamdy | https://link.springer.com/article/10.1186/s12872-024-03982-0 | Patients with post-COVID symptoms and ventricular arrhythmia had subclinical myocardial damage, evidenced by speckle tracking echocardiography while having apparently preserved LV systolic function. The burden of ventricular arrhythmia in post-COVID patients significantly correlated with increased inflammatory biomarkers and reduced biventricular strain. | |||||||||||||||||||||
140 | Evaluation of myocardial work and exercise capacity in patients recovered from the severe form of COVID-19 | 2024-08-19 | https://doi.org/10.1016/j.ijcrp.2024.200324 | Thiago Lins Fagundes de Sousa | https://pubmed.ncbi.nlm.nih.gov/39258008/ | Our findings revealed an increased wasted work, with lower myocardial efficiency, significantly reduced aerobic exercise capacity, and abnormal heart rate response during recovery, which may be related to previously described late symptoms. The reduction in functional capacity during physical exercise is partly associated with a decrease in resting myocardial work efficiency. | |||||||||||||||||||||
141 | Risk Impact of SARS-CoV-2 Coronavirus and Spike Protein on Cardiac Tissue: A Comprehensive Review | 2024-08-19 | https://doi.org/10.33549/physiolres.935476 | Omar ŠERÝ | https://www.biomed.cas.cz/physiolres/pdf/73%20Suppl%203/73_S655.pdf | SARS-CoV-2 has a profound and multifaceted impact on cardiac tissue, mediated primarily through the Spike protein's interaction with the ACE2 receptor. The virus not only causes direct damage to the heart by infecting cardiomyocytes but also triggers significant systemic effects that can exacerbate preexisting cardiovascular conditions. The extensive expression of ACE2 in heart cells underpins the high susceptibility of cardiac tissues to SARS-CoV-2, leading to a range of complications from myocarditis to severe myocardial dysfunction. | |||||||||||||||||||||
142 | SARS-CoV-2 Damages Cardiomyocytes Mitochondria and Implicates Long COVID-associated Cardiovascular Manifestations | 2024-08-20 | https://doi.org/10.1101/2024.08.18.24311961 | Wenliang Che | https://www.medrxiv.org/content/10.1101/2024.08.18.24311961v1 | We have observed an interesting phenomenon in the mitochondria, the swollen and vacuolated mitochondria, distorted and broken cristae, all indicated severe damage to this important cellular organelle. This damage is highly likely caused by the SARS-CoV2 Infection, as we have found an almost identical mitochondria disorganization in the mice that were infected with SARS-CoV-2. Mitochondrial damage has profound implications for cellular respiration, ATP production, and metabolism, potentially precipitating cardiovascular, neurodegenerative, and metabolic disorders. | |||||||||||||||||||||
143 | The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management | 2024-08-23 | https://doi.org/10.1007/s11239-024-03028-4 | Richard C. Becker | https://link.springer.com/article/10.1007/s11239-024-03028-4 | In 18 818 outpatients with COVID-19 and 93,179 matched uninfected participants, the infection was associated with an increased risk of VTE (venous thromboembolism) at 30 days (incidence rate of 50.99 and 2.37 per 1000 person-years for infected and uninfected people, respectively; HR, 21.42). An inherited thrombophilia was associated with a HR of 2.05 (95%CI, 1.15–3.66) for post–COVID-19 VTE. | |||||||||||||||||||||
144 | Cardiac remodeling and inflammation detected by magnetic resonance imaging in COVID-19 survivors | 2024-08-27 | https://doi.org/10.1016/j.ijcha.2024.101499 | Eduardo B. Schaustz | https://www.sciencedirect.com/science/article/pii/S2352906724001659 | Among COVID-19 survivors with myocardial injury during the acute phase of the disease, the incidences of nonischemic myocardial and pericardial LGE and CMR imaging–detected signs of cardiac remodeling, partially reversed during follow-up, were high. Myocardial injury in the acute phase of COVID-19 is associated with a high prevalence CMR imaging–detected cardiac sequelae. | |||||||||||||||||||||
145 | Fibrin drives thromboinflammation and neuropathology in COVID-19 | 2024-08-28 | https://doi.org/10.1038/s41586-024-07873-4 | Jae Kyu Ryu | https://www.nature.com/articles/s41586-024-07873-4 | Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive systemic thromboinflammation and neuropathology in COVID-19. Fibrin promotes neuroinflammation and neuronal loss after infection, as well as innate immune activation in the brain and lungs independently of active infection. | |||||||||||||||||||||
146 | Persistent Post COVID-19 Endothelial Dysfunction and Oxidative Stress in Women | 2024-08-28 | https://doi.org/10.3390/pathophysiology31030033 | Natalya Semenova | https://www.mdpi.com/1873-149X/31/3/33 | The high content of lipid peroxidation products 12 months post COVID-19+, despite decrease in ENDs, indicates long-term changes in free radical homeostasis. These data indicate increased levels of lipid peroxidation production contribute, in part, to the development of free radical related pathologies including long-term post COVID syndrome. | |||||||||||||||||||||
147 | A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID | 2024-08-28 | https://doi.org/10.3390/life14091076 | Aristotle G. Koutsiaris | https://www.mdpi.com/2075-1729/14/9/1076 | Disruption of peripheral tissue blood supply by the contribution of both ML (Microvascular loss) and HD (hemodynamic decrease) is proposed here to be the principal cause of the mechanism leading to Long COVID symptoms. The estimated SR for multiple tissues with data from 634 post-COVID patients reached a sizeable 47%. This large SR (blood supply reduction) creates conditions of lower mass diffusion rates, hypoxia, and undernutrition. | |||||||||||||||||||||
148 | Thrombotic Consequences of COVID-19 Infection on Microsurgical Reconstruction | 2024-08-29 | https://doi.org/10.1002/micr.31219 | Sabrina H. Han | https://onlinelibrary.wiley.com/doi/10.1002/micr.31219 | COVID-19 has dire, long-lasting effects on virtually every organ system, chief among them, the microcirculation. Matched case analysis determined a 4.8 times increased odds ratio of postoperative complications in the COVID-19 group compared with controls (p = 0.002). | |||||||||||||||||||||
149 | Infiltrating monocytes drive cardiac dysfunction in a cardiomyocyte-restricted mouse model of SARS-CoV-2 infection | 2024-08-29 | https://doi.org/10.1128/jvi.01179-24 | Oleksandr Dmytrenko | https://journals.asm.org/doi/10.1128/jvi.01179-24 | We designed a mouse in which only heart muscle cells can be infected with a SARS-CoV-2 strain to study cardiac infection in isolation from other organ systems. In our model, infected mice show viral infection, worse function, and accumulation of immune cells in the heart. A subset of immune cells facilitates such worsening heart function. | |||||||||||||||||||||
150 | The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII | 2024-09-05 | https://doi.org/10.1101/2024.09.05.611400 | Anna Pagotto | We unveil a novel mechanism linking SARS-CoV-2 infection to thrombotic complications in COVID-19. Here we show that the SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade. Adding Mpro to human plasma from healthy donors increased clotting probability by 2.5-fold. | ||||||||||||||||||||||
151 | Sex-related differences concerning the profile and evolution of cardiovascular complications in patients with post-acute COVID-19 syndrome | 2024-09-06 | https://doi.org/10.1016/j.lfs.2024.123044 | Cristina Tudoran | https://www.sciencedirect.com/science/article/abs/pii/S0024320524006349 | Male patients had a higher tendency to develop altered LVSF (left ventricular systolic function), while female subjects had more frequently impaired RVF (right ventricular function) and DD (diastolic dysfunction). These abnormalities alleviated in time and exerted a significant influence on patients' functional status. | |||||||||||||||||||||
152 | Arterial stiffness in adults with Long COVID in sub-Saharan Africa | 2024-09-09 | https://doi.org/10.14814/phy2.70029 | Chikopela Theresa | https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70029 | Peripheral arterial stiffness was higher in adults with Long COVID than in controls who were never infected with SARS-CoV-2 as noted by the elevated levels of crPWV (carotid-radial-PWV) and crASI (carotid-radial-arterial stiffness index) among adults with Long COVID. The Long COVID group had higher carotid-radial-PWV (crPWV) than controls (10 m/s interquartile range [IQR] 8.5-11.2 m/s) versus 8.8 m/s (IQR 7.7-9.2 m/s) as was their carotid-radial-arterial stiffness index (crASI) (2.26 cm/ms (IQR 1.9-2.56 cm/ms) vs. 2.01 cm/ms (IQR 1.82-2.27 cm/ms); p < 0.05) in both. They also had more type-A waveforms, indicating increased arterial stiffening. | |||||||||||||||||||||
153 | 5-hydroxymethylcytosine Epigenetic Markers in COVID-19-Associated Acute Coronary Syndrome: Insights into Neutrophil Activation and PDE4D Upregulation | 2024-09-10 | https://doi.org/10.1101/2024.09.09.24313367 | Zhongheng Li, | https://www.medrxiv.org/content/10.1101/2024.09.09.24313367v1 | Further analysis showed that COVID-19 infection may affect the occurrence and development of ACS (Acute Coronary Symdrome) by abnormally up-regulating PDE4D gene expression. | |||||||||||||||||||||
154 | Symptom burden, coagulopathy and heart disease after acute SARS-CoV-2 infection in primary practice | 2024-09-11 | https://doi.org/10.1038/s41598-024-71535-8 | Roisin Colleran | https://www.nature.com/articles/s41598-024-71535-8 | In a cohort of primary practice patients recently recovered from SARS-CoV-2 infection, prevalence of persistent symptoms and markers of abnormal coagulation were high, despite a lower frequency of abnormalities on CMR compared with prior reports of patients assessed in a hospital setting. Left ventricular ejection fraction was below the normal reference limit in 17.4% of patients. Von Willebrand factor antigen was elevated in 32.7% of patients and Fibrinogen and D-Dimer levels were found to be elevated in 10.2% and 11.1% of patients, respectively. | |||||||||||||||||||||
155 | A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19 | 2024-09-12 | https://doi.org/10.1172/JCI183777 | Valentina Trimarco | https://www.jci.org/articles/view/183777 | During the COVID-19 period, we detected an increased risk of developing any dyslipidemia when compared with the pre–COVID-19 triennium (OR = 1.29; 95% CI, 1.19–1.39). Taken together, our data reveal a notable rise in dyslipidemia incidence during the COVID-19 pandemic, suggesting the utility of establishing specialized clinical monitoring protocols for patients who survive COVID-19 to mitigate the risk of developing dyslipidemia. | |||||||||||||||||||||
156 | COVID-19’s Impact on Athletes: Reduced Cardiorespiratory fitness after a SARS-CoV-2 Infection | 2024-09-16 | 0.1249/MSS.0000000000003560 | Hasler, Erik | https://journals.lww.com/acsm-msse/abstract/9900/covid_19_s_impact_on_athletes__reduced.618.aspx | A SARS-CoV-2 infection is associated with a decline in cardiorespiratory fitness in athletes for approximately 60 days. A SARS-CoV-2 infection was associated with a decrease in POIAT/kg (-0.123 W/kg, p < 0.001), POmax/kg (-0.099 W/kg, p = 0.002), measured V̇O2max/kg (-1.70 ml/min/kg, p = 0.050) and an increase HRIAT (2.50 b/min, p = 0.008), HRmax (2.59 b/min, p < 0.001) within the first 60 days after SARS-CoV-2 infection. | |||||||||||||||||||||
157 | Cardiac Function and Functional Capacity in Patients with Long COVID: a Comparison to Propensity-Matched Community Controls | 2024-09-17 | https://doi.org/10.1016/j.echo.2024.09.006 | 39299352 | Thomas H Marwick | https://pubmed.ncbi.nlm.nih.gov/39299352/ | Impaired GLS (global longitudinal strain) and LV (left ventricular) dimensions are the echocardiographic features that are over-represented in Long COVID, As expected, the Long COVID group had significant subjective (<85% predicted METS; 72% vs 5%, p<0.001) and objective functional impairment (29% vs 24%, p=0.026), but GLS was only weakly associated with both subjective (r=0.30, p=0.005) and objective (r=0.21, p=0.05) functional impairment. | ||||||||||||||||||||
158 | Risk of death and cardiovascular events following COVID-19 vaccination or positive SARS-CoV-2 test amongst adult Singaporeans during omicron transmission | 2024-09-18 | https://doi.org/10.1016/j.vaccine.2024.126356 | Liang En Wee | https://www.sciencedirect.com/science/article/abs/pii/S0264410X24010387 | No elevated risk of all-cause mortality/cardiovascular events was observed across all age strata post-vaccination. Elevated risk of cardiovascular events 1–2 months after any SARS-CoV-2 infection was observed across all age strata, with elevated risk observed in older adults >180 days post-infection (adjusted-hazards-ratio, aHR = 1.18, 95 %CI = 1.04–1.34). | |||||||||||||||||||||
159 | Clinical characteristics, diagnosis and short-term outcomes of COVID-19–associated acute myocarditis in China | 2024-09-19 | https://doi.org/10.1002/ehf2.15048 | Huihui Liu | https://onlinelibrary.wiley.com/doi/10.1002/ehf2.15048 | The majority of COVID-19–associated AM occurred within 2 weeks of Omicron variant infection. Fulminant myocarditis complicated by hemodynamic instability requiring temporary mechanical circulatory support was not uncommon. Eighteen patients (64.3%) were prescribed with corticosteroids, and seven patients (25.0%) underwent temporary mechanical circulatory support. Only two patients died during hospitalization. | |||||||||||||||||||||
160 | Severity, mortality, and incidence of venous thromboembolism in COVID-19 patients | 2024-09-19 | https://doi.org/10.1186/s43168-024-00330-w | Ahmed Al-Husseiny Ali | https://link.springer.com/article/10.1186/s43168-024-00330-w | Moderate cases comprised 63.8% of the total study population, 22.4% were severe cases, and 13.8% were critical cases. The mortality rate was 8.13% and 6.1% developed venous thromboembolism. The severity of the disease greatly influences the incidence of venous thromboembolism and the outcome of the disease. | |||||||||||||||||||||
161 | Coronary implications of COVID-19 | 2024-09-20 | https://doi.org/10.1159/000541553 | Andreas S. Triantafyllis | https://karger.com/mpp/article/doi/10.1159/000541553/913566/Coronary-implications-of-COVID-19 | COVID-19 associated myocardial insult exposes patients to a higher mortality risk. SARS-CoV-2 has been reported to attack the coronary arterial bed with various mechanisms including thrombosis/rupture of pre-existing atherosclerotic plaque, de novo coronary thrombosis, endothelitis, microvascular dysfunction, vasculitis, vasospasm and ectasia/aneurysm formation. | |||||||||||||||||||||
162 | Clinical Presentation and Outcomes of Myocarditis Among the COVID-19 Pediatric Population: A Review of 100 Cases | 2024-09-21 | 10.7759/cureus.69885 | Ashfaq Ahmed | https://www.cureus.com/articles/273145-clinical-presentation-and-outcomes-of-myocarditis-among-the-covid-19-pediatric-population-a-review-of-100-cases#!/ | Among 100 children (with a confirmed COVID-19 by PCR and a myocarditis diagnosis), 26 died while 74 recovered. Elevated cardiac enzymes and positive Troponin-I levels were found in 91 and 84 children, respectively. Tachycardia was observed in 91 children. | |||||||||||||||||||||
163 | COVID-19 Recovery and Cardiovascular Health: The Interplay Between Fetuin-A and Blood Pressure | 2024-09-22 | https://doi.org/10.7759/cureus.69905 | 39439628 | Montather F Ramadan | https://pubmed.ncbi.nlm.nih.gov/39439628/ | The increase in fetuin-A among hypertensive patients suggests that COVID-19 may enhance cardiovascular risk, highlighting the need for stricter monitoring and tailored treatment strategies. The study showed that patients who had survived COVID-19 had significantly higher levels of fetuin-A compared to healthy controls, with a mean concentration of 103.64 mg/L versus 19.199 mg/L (p < 0.001). These results suggest that COVID-19 may alter the usual relationship between blood pressure and cardiovascular biomarkers. | ||||||||||||||||||||
164 | The risk factors for long term cardiovascular symptoms in patients after coronavirus disease 2019 infection | 2024-09-24 | https://doi.org/10.1080/07853890.2024.2407065 | Tingting Liu | https://pubmed.ncbi.nlm.nih.gov/39317338/ | Anxiety and depression, C-reactive protein, D-dimer, and LDL-C levels are associated with the development of post COVID-19 long-term cardiovascular symptoms. Anxiety and depression (odds ratio [OR] = 6.403), C-reactive protein (OR = 1.009), D-dimer (OR = 1.455), and LDL-C (OR = 1.780) were identified as independent risk factors for post COVID-19 long-term cardiovascular symptoms. | |||||||||||||||||||||
165 | Use of cardiopulmonary exercise testing to identify mechanisms of exertional symptoms in children with long COVID | 2024-09-26 | https://doi.org/10.1002/pmrj.13263 | Adam Lowe | https://onlinelibrary.wiley.com/doi/10.1002/pmrj.13263 | Decreased aerobic activity due to multiple factors was found in 47% of children with a history of COVID-19. Nearly half of the children (47%) demonstrated decreased exercise capacity with 30% displaying limitations due to deconditioning, 22% limited by body habitus, and 13% due to bronchospasm. | |||||||||||||||||||||
166 | RNA-Seq analysis of human heart tissue reveals SARS-CoV-2 infection and inappropriate activation of the TNF-NF-κB pathway in cardiomyocytes | 2024-09-27 | https://doi.org/10.1038/s41598-024-69635-6 | Kirtan Dave | https://www.nature.com/articles/s41598-024-69635-6 | Our data establish that SARS-CoV-2 infects cardiomyocytes by the TNF-NF-κB pathway, potentially triggering acute cardiovascular complications and increasing the long-term cardiovascular risk in COVID-19 patients. | |||||||||||||||||||||
167 | The influence of COVID-19 on short-term mortality in acute ischemic stroke: A systematic review and meta-analysis | 2024-09-27 | 10.1097/MD.0000000000039761 | Xue, Yi-dong | https://journals.lww.com/md-journal/fulltext/2024/09270/the_influence_of_covid_19_on_short_term_mortality.90.aspx | The results of this study suggest that AIS (acute ischemic stroke) patients with SARS-CoV-2 have higher short-term mortality compared to AIS patients without SARS-CoV-2. The overall results show that in-hospital and 90-day mortality was 3.31-fold higher in AIS with SARS-CoV-2 patients compared with those without SARS-CoV-2. | |||||||||||||||||||||
168 | Sex-Based Differences in Pulmonary Function and Cardiopulmonary Response 30 Months Post-COVID-19: A Brazilian Multicentric Study | 2024-09-27 | https://doi.org/10.3390/ijerph21101293 | Cássia da Luz Goulart | https://www.mdpi.com/1660-4601/21/10/1293 | Women exhibited more pronounced impairments in several key indicators of cardiopulmonary function 30 months post-infection. Regarding respiratory muscle strength, a significant reduction in MIP (maximum inspiratory pressure) observed in women suggests greater respiratory muscle weakness, adversely affecting long-term functional capacity and quality of life. Specifically, women demonstrated a reduced WR (peak work rate), reduced VO2% predicted, reduced O2 pulse, and OUES% predicted when compared to men. | |||||||||||||||||||||
169 | Detection of Subclinical Myocardial Dysfunction by Speckle Tracking Echocardiography in Young Adults recovered from mild COVID-19 | 2024-09-30 | https://doi.org/10.58675/2682-339X.2667 | Ali E. Oraby | https://aimj.researchcommons.org/cgi/viewcontent.cgi?article=2667&context=journal | While conventional echocardiographic evaluations showed no significant differences between the groups, LV GLS was notably lower in the COVID-19 group (-24.8%) compared to the controls (-26.5%). This reduction in LV GLS, identified solely through STE, suggests myocardial dysfunction. COVID-19 is an independent predictor of reduced LV GLS after adjusting for potential confounding factors. | |||||||||||||||||||||
170 | Impacts of COVID-19 on hemostasis: coagulation abnormalities and management perspectives | 2024-10-01 | 10.1097/MS9.0000000000002237 | Obeagu, Emmanuel Ifeanyi | https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2024/10000/impacts_of_covid_19_on_hemostasis__coagulation.30.aspx | COVID-19 has been associated with a higher incidence of thrombotic events. The virus can directly infect endothelial cells, leading to endothelial dysfunction and activation. COVID-19 induces a state of hypercoagulability characterized by elevated levels of fibrinogen, D-dimer, and other coagulation markers. Coagulation abnormalities in COVID-19 patients necessitates careful monitoring and management of anticoagulation therapy. | |||||||||||||||||||||
171 | Association between SARS-CoV-2 and Stroke: Perspectives from a metaumbrella-review | 2024-10-03 | https://doi.org/10.1101/2024.10.01.24314742 | Andreza Maria Luzia Baldo de Souza | https://www.medrxiv.org/content/10.1101/2024.10.01.24314742v1 | The association between SARS-CoV-2 and stroke was consistent and significant, suggesting that COVID-19 should be considered a new risk factor for cerebrovascular diseases. The analysis showed that the severity of COVID-19 is significantly associated with an increased risk of stroke (eOR = 2.48; 95%CI: 1.55 - 3.95), particularly for ischemic stroke (eOR = 1.76; 95%CI: 1.11 - 2.80) and hemorrhagic stroke (eOR = 3.86; 95%CI: 1.79 - 8.33). | |||||||||||||||||||||
172 | Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era | 2024-10-07 | https://doi.org/10.3389/fmicb.2024.1470953 | Zhan Wang | This review innovatively and systematically summarizes the potential mechanisms of COVID-19-associated myocardial fibrosis at the molecular and cellular levels. SARS-CoV-2 can activate cardiac fibroblasts to lead to myocardial fibrosis. Similarly, immune cells, endothelial cells, pericytes, and cardiomyocytes are also involved in the deleterious process. In addition to short-term damage, the long-term sequelae caused by COVID-19 should not be underestimated. | ||||||||||||||||||||||
173 | COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals | 2024-10-08 | https://doi.org/10.1111/cpf.12909 | Mushidur Rahman | https://onlinelibrary.wiley.com/doi/10.1111/cpf.12909 | Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012). | |||||||||||||||||||||
174 | COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type | 2024-10-09 | https://doi.org/10.1161/ATVBAHA.124.321001 | James R. Hilser | https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.321001 | Hospitalization for COVID-19 represents a coronary artery disease risk equivalent, with post–acute myocardial infarction and stroke risk particularly heightened in non-O blood types. The risk of MACE (major adverse cardiac events) was elevated in COVID-19 cases at all levels of severity (HR, 2.09) and to a greater extent in cases hospitalized for COVID-19 (HR, 3.85). | |||||||||||||||||||||
175 | Systematic review of case reports on COVID-19 associated myocarditis: a discussion on treatments | 2024-10-09 | https://doi.org/10.1186/s12985-024-02499-4 | Vanessa Lim | https://virologyj.biomedcentral.com/articles/10.1186/s12985-024-02499-4 | ECG abnormalities, elevated inflammatory markers, and reduced left ventricular ejection fraction were most associated with COVID-19 myocarditis. While classic symptoms of COVID-19 include upper respiratory symptoms, a subset of patients diagnosed with COVID-19 displayed no signs of respiratory disease at all. In 22% of cases, cardiac sequelae was not present until after the patient recovered from COVID-19. | |||||||||||||||||||||
176 | Cardiac Function and Structure before and after Mild SARS-CoV-2 Infection in Elite Athletes Using Biventricular and Left Atrial Strain | 2024-10-11 | https://doi.org/10.3390/biomedicines12102310 | Jana Schellenberg | https://www.mdpi.com/2227-9059/12/10/2310 | A significant increase was observed in LA reservoir strain (LASr) (35.7% vs. 47.8%, p = 0.012). Compared to CON (healthy controls), INFAt (elite athletes before and after infection) at t1 had significantly higher RV FWS (right ventricular free wall longitudinal strain) (−33.0% vs. −28.2%, p = 0.011), LASr (left atrial strain) (47.8% vs. 30.5%, p < 0.001) and LA contraction strain (−12.8% vs. −4.9%, p = 0.050) values. | |||||||||||||||||||||
177 | Baseline level of interleukin-6 is associated with the risk of acute coronary syndrome development in SARS-CoV‐2 infection | 2024-10-12 | https://doi.org/10.1186/s12872-024-04234-x | Mohsen Sedighi | https://link.springer.com/article/10.1186/s12872-024-04234-x | Among 1,753 COVID-19 patients, 37 cases experienced ACS (Acute coronary syndrome). Decreased level of consciousness (31.6% vs. 2.5%, p = 0.001), ICU admission (65% vs. 2%, p = 0.001), and mortality events (70% vs. 0.6%, p = 0.001) were more prevalent in the ACS group. Elderly and concurrent CVD are significantly associated with ACS development. | |||||||||||||||||||||
178 | CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID | 2024-10-14 | https://doi.org/10.1038/s44161-024-00543-8 | Dilip Thomas | https://www.nature.com/articles/s44161-024-00543-8 | CCL2-induced oxidative stress promoted post-translational modification of cardiac proteins, leading to cardiac dysfunction. These findings suggest that EC(endothelial cells)-released cytokines contribute to cardiac dysfunction in long COVID, highlighting the importance of early vascular health monitoring in patients with long COVID. | |||||||||||||||||||||
179 | Case Series: Cervical arterial dissections in the setting of recent COVID-19 | 2024-10-14 | doi: 10.3389/fstro.2024.1366947 | Sanghee Lim | https://www.frontiersin.org/journals/stroke/articles/10.3389/fstro.2024.1366947/abstract | COVID-19 infections may predispose patients to spontaneous cervical arterial dissections. Such patients can have variable neurologic presentations, though headaches and neck pain were common complaints | |||||||||||||||||||||
180 | COVID-19 incidence and cardiorespiratory fitness among first-year college students | 2024-10-14 | https://doi.org/10.3389/fpubh.2024.1468300 | Catherine E. Alvaro | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1468300/full | Nearly a quarter, (24%) perceived a negative impact of COVID-19 on their CRF (cardiorespiratory fitness) and although not statistically significant, participants who contracted COVID-19 had 46% lower odds of having a positive perception of CRF than those who did not contract COVID-19 before. | |||||||||||||||||||||
181 | Perioperative cardiovascular risk and preventions of patients with post-COVID-19 condition | 2024-10-14 | https://doi.org/10.1016/j.heliyon.2024.e39345 | Sixu Lai | https://www.cell.com/heliyon/fulltext/S2405-8440(24)15376-5 | Post-COVID-19 condition significantly increase perioperative cardiovascular risk. | |||||||||||||||||||||
182 | Self-reported fatigue in people with post COVID-19: impact on functioning in daily life, and associated factors - a cross-sectional study | 2024-10-15 | https://doi.org/10.2340/jrm.v56.40811 | Christina Brogårdh | https://pubmed.ncbi.nlm.nih.gov/39404456/ | This study found that self-reported fatigue is common among people with post-COVID-19, and negatively impacts functioning in daily life. A majority (≥ 84%) reported both physical fatigue and mental fatigue, according to the Fatigue Severity Scale and Mental Fatigue Scale. The fatigue impacted motivation, physical functioning, work, family, or social life, and increased sensitivity to stress and concentration difficulties. | |||||||||||||||||||||
183 | Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry | 2024-10-15 | https://doi.org/10.20944/preprints202410.1180.v1 | Athanasios Moulias | https://www.preprints.org/manuscript/202410.1180/v1 | This study demonstrates that COVID-19 adversely affects endothelial function, as evidenced by a reduction in the hyperemic vascular response index, and the endothelial dysfunction may also persist. The proportion of COVID-19 patients with endothelial dysfunction (LnRHI≤0.51) was 61% during hospitalization, and 55% at six months. | |||||||||||||||||||||
184 | Post-acute COVID-19 syndrome: prevalence of peripheral microvascular endothelial dysfunction and associations with NT-proBNP dynamics | 2024-10-16 | https://doi.org/10.1016/j.amjmed.2024.10.012 | Marcus Ståhlberg | https://www.amjmed.com/article/S0002-9343%2824%2900642-9/fulltext | Peripheral microvascular endothelial dysfunction was prevalent in a symptomatic PACS population long after recovery from a mild acute infection. In total, 41% of PACS subjects had microvascular endothelial dysfunction and 20% had impaired RHI (Reactive hyperemia index). | |||||||||||||||||||||
185 | A pooled analysis of the incidence and mortality risk of atrial fibrillation in patients with COVID-19 | 2024-10-16 | https://doi.org/10.7717/peerj.18330 | Nan-Nan Shen | https://peerj.com/articles/18330/ | This study comprehensively investigated the association between AF and COVID-19 in a real-world setting. Notably, severe COVID-19 patients displayed a significantly elevated prevalence of AF at 14.l% (95% CI [13.3–14.9%]), which was approximately 2.5-fold higher than that in non-severe patients (5.2%, 95% CI [4.8–5.5%]). Both pre-existing (HR: 1.83, 95% CI [1.49–2.17]) and new-onset AF (HR: 3.47, 95% CI [2.26–5.33]) were associated with an increased mortality risk among COVID-19 patients. | |||||||||||||||||||||
186 | Arterial floating mural thrombi are a characteristic imaging pattern in SARS-CoV-2-related ischemic stroke | 2024-10-25 | https://doi.org/10.1371/journal.pone.0311622 | Keshet Pardo | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0311622 | Floating arterial mural thrombi attached to atherosclerotic plaques are unique characteristic source of AIS (Acute ischemic stroke) in SARS-CoV-2 patients. They may lead to ischemic stroke in patients with mild or asymptomatic infection up to 1–2 weeks from SARS-CoV-2 diagnosis. | |||||||||||||||||||||
187 | The alarming link between the COVID-19 pandemic and stroke: why ignoring this association after relapse of the disease has dangerous consequences | 2024-10-28 | https://doi.org/10.1515/jbcpp-2024-0179 | Nader Aghakhani | https://www.degruyter.com/document/doi/10.1515/jbcpp-2024-0179/html | The COVID-19 pandemic has increased the risk of severe strokes in individuals with preexisting cardiovascular disease, leading to worse outcomes. The virus disrupts stroke care globally and can cause strokes in patients with severe respiratory symptoms and even in young adults without typical risk factors | |||||||||||||||||||||
188 | Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function | 2024-10-30 | https://doi.org/10.1038/s41564-024-01838-z | Jane E. Sinclair | https://www.nature.com/articles/s41564-024-01838-z | This study shows that donors with PASC-CVS have elevated levels of trace-level plasma cytokines at approximately 18 months post infection, which are associated with the altered functionality of cardiomyocytes in vitro. The presence of inflammatory cytokines is known to affect cardiovascular function. | |||||||||||||||||||||
189 | A Deeper Look at Long-Term Effects of COVID-19 on Myocardial Function in Survivors with No Prior Heart Diseases: A GRADE Approach Systematic Review and Meta-Analysis | 2024-10-31 | doi: 10.3389/fcvm.2024.1458389 | Mahshid Dehghan | https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1458389/abstract | Post-COVID individuals with no prior heart diseases showed significant changes in left ventricular (LV) and right ventricular (RV) echocardiographic indices compared to controls. These significant findings were seen in both postacute and long-COVID survivors regardless of the severity of initial infection.This review implies that individuals recovering from post-acute and long-term effects of COVID-19 may experience changes in myocardial function as a result of the novel coronavirus. | |||||||||||||||||||||
190 | Treatment and long term follow-up results in patients with pulmonary vascular thrombosis related to COVID-19 | 2024-11-01 | DOI: 10.1097/MD.0000000000040319 | Aliyeva, Nigar | https://journals.lww.com/md-journal/fulltext/2024/11010/treatment_and_long_term_follow_up_results_in.14.aspx | Over 24-month follow-up period, mortality, relapse, chronic thromboembolic hypertension and thromboembolic disease was observed in 2%, 2.2%, 4.9%, and 9.9% of patients, respectively. While the pathophysiology of COVID-19-associated PTE (pulmonary thromboembolism) may be attributed to alternative mechanisms, the observed rates of mortality, recurrence, and CTEPH (chronic thromboembolic pulmonary hypertension) were comparable to those of non-COVID-related PTE. | |||||||||||||||||||||
191 | Cardiovascular sequelae in symptomatic SARS-CoV-2 infection survivors | 2024-11-07 | https://doi.org/10.5603/cj.99538 | Grzegorz Skonieczny | https://journals.viamedica.pl/cardiology_journal/article/view/99538 | The median time to follow-up was 126 days. At that time, only 3.5% of patients reported no persistent dyspnea, chest pain, or fatigue on exertion. This cohort study reports on a ubiquitous presence of persistent cardiovascular symptoms at follow-up in COVID-19 patients irrespective of the severity of clinical presentation of the acute episode. | |||||||||||||||||||||
192 | Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults | 2024-11-10 | https://doi.org/10.21203/rs.3.rs-5081257/v1 | Sagya Khanal | https://www.researchsquare.com/article/rs-5081257/v1 | Individuals with COVID-19 infection are more likely to develop cardiovascular complications compared to influenza and RSV. The odds of myocarditis was 61% lower in influenza [aOR = 0.39 (0.20–0.76), P = 0.006], and 85% lower in RSV [aOR = 0.15 (0.07–0.34) P < 0.001] as compared to COVID-19. | |||||||||||||||||||||
193 | Effect of SARS-CoV-2 Infection on Selected Parameters of the Apelinergic System in Repeat Blood Donors | 2024-11-12 | https://doi.org/10.3390/biomedicines12112583 | Marta Stanek | The results suggest that infection with SARS-CoV-2 causes changes in the parameters of the apelinergic system, both after a short period of time has passed since the onset of the SARS-CoV-2 infection, and even up to 4 months after the infection. Interestingly, APJ levels remained significantly lower, indicating a prolonged disruption of the apelinergic system. The persistent downregulation of APJ could have long-term implications for cardiovascular health, as this receptor is essential for mediating the effects of both AP and ELA. | ||||||||||||||||||||||
194 | The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII | 2024-11-13 | https://doi.org/10.21203/rs.3.rs-4959212/v1 | Vincenzo De Filippis | https://www.researchsquare.com/article/rs-4959212/v1 | Here we show that SARS-CoV-2 main protease (Mpro) can play a direct role in the activation of the coagulation cascade. Adding Mpro to human plasma increased clotting probability by 2.5-fold. Overall, integrating biochemical, proteomics and structural biology experiments, we unveil a novel, additional mechanism linking SARS-CoV-2 infection to thrombotic complications in COVID-19. | |||||||||||||||||||||
195 | Long-Term Coronary Microvascular and Cardiac Dysfunction Following Severe COVID-19 Hospitalization | 2024-11-15 | https://doi.org/10.1101/2024.11.14.24317343 | Rebecka Steffen Johansson | https://www.medrxiv.org/content/10.1101/2024.11.14.24317343v1 | COVID-19 patients exhibit long-term reduced stress perfusion indicating CMD (coronary microvascular dysfunction), and impaired LV (left ventricular) function by GLS (global longitudinal strain) and GCS (global circumferential strain). There were no differences in stress perfusion or myocardial perfusion reserve between COVID-19 patients with or without cardiovascular risk factors or cardiac symptoms. | |||||||||||||||||||||
196 | Cardiovascular Magnetic Resonance Reveals Cardiac Inflammation and Fibrosis in Symptomatic Patients with Post-COVID-19 Syndrome: Findings from the INSPIRE-CMR Multicenter Study | 2024-11-17 | https://doi.org/10.3390/jcm13226919 | George Markousis-Mavrogenis | https://www.mdpi.com/2077-0383/13/22/6919 | Our patients can be clinically characterized as having chronic myocarditis, as all of them had cardiac symptoms with consequent CMR (cardiovascular magnetic resonance) evaluation at a time between 3 and 8 months from COVID-19 and the onset of cardiac symptoms. An interesting finding in our patients is that the 1/3 of them still had increased T2 mapping and/or a combination of increased native T1 and T2 mapping values. This supports that COVID-19 can still provoke an acute myocardial reaction months after COVID-19 infection. . In our study, the one-year clinical follow up available in around 1/3 of patients identified the presence of shortness of breath, chest pain, and arrhythmia. | |||||||||||||||||||||
197 | Risks of major arterial and venous thrombotic diseases after hospitalisation for influenza, pneumonia, and COVID-19: A population-wide cohort in 2.6 million people in Wales | 2024-11-19 | https://doi.org/10.1016/j.thromres.2024.109213 | Spencer Keene | https://www.sciencedirect.com/science/article/abs/pii/S0049384824003451 | Both hospitalisation for COVID-19 or pneumonia/influenza increase the risk of arterial and venous thrombosis. The number of excess arterial and venous thromboses was slightly higher after hospitalisation for COVID-19. Elevated aHRs declined with time after hospitalised infection but remained elevated for 75 weeks. | |||||||||||||||||||||
198 | An exploration of the connection between COVID-19 and cardiovascular disease (CVD) in European countries | 2024-11-21 | https://doi.org/10.1007/s10389-024-02372-2 | Niloufar Pourshir Sefidi | https://link.springer.com/article/10.1007/s10389-024-02372-2 | Our findings indicate a 20% average increase in CVD risk post-COVID-19 infection, associated with other risk factors such as hypertension, diabetes, chronic lung disease, and elevated BMI. | |||||||||||||||||||||
199 | Exercise stress echocardiography shows impaired left ventricular function after hospitalization with COVID-19 without overt myocarditis: A pilot study | 2024-11-28 | https://doi.org/10.14814/phy2.70138 | Robert E. Goldstein | https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70138 | ESE (Exercise stress echocardiography) uniquely identified residual abnormality in cardiac contractile function not evident unstressed, exposing previously unrecognized residual influence of COVID-19. At peak stress, RP (Recovering Patients) had significantly lower mean left ventricular (LV) ejection fraction (67% ± 7 vs. 73% ± 5, p < 0.0017) and higher peak early mitral inflow velocity/early mitral annular velocity (E/e’, 9.1 ± 2.5 vs. 6.6 ± 2.5, p < 0.006) compared with HS (Healthy Subjects) performing equal exercise (8.5 ± 2.6 min). | |||||||||||||||||||||
200 | Cardiac manifestations of pediatric COVID-19 and multisystem inflammatory syndrome in children | 2024-12-09 | https://doi.org/10.1016/j.ppedcard.2024.101784 | Jakarinya Mangalamoorthy | https://www.sciencedirect.com/science/article/abs/pii/S1058981324000833 | Pericarditis may occur in 4.5 % of children with acute COVID-19 and 12 % to 25 % with MIS-C. Coronary artery abnormalities including dilation and aneurysm may occur in 0.9 % of patients who have severe acute COVID-19 and 13 % to 24 % of patients who have MIS-C. Arrhythmias occur in children who have severe cases of COVID-19 and 7 % to 60 % of children who have MIS-C and may include atrial tachycardia, atrial fibrillation, complete atrioventricular block, and ventricular tachycardia. | |||||||||||||||||||||
201 | The Assessment of Muscle Strength and Cardiorespiratory Parameters Using Simple Tests in Older Adults With Recovery From Mild COVID-19 | 2024-12-10 | https://doi.org/10.5535/arm.240033 | Patchareeya Amput | https://www.e-arm.org/journal/view.php?doi=10.5535/arm.240033 | Older adults with recovery from mild COVID-19 reported reduced muscle strength and exercise tolerance when compared with older adults without COVID-19. The recovered group showed significant differences in handgrip strength test (24.73±6.99 vs. 22.03±4.36, p=0.041) and duration for the STS10 (sit-to-stand test) (25.15±6.11 vs. 33.40±7.56, p<0.001) when compared to the control group. The recovered group had also significantly decreased distances for the 6MWT (6-minute walk test) (421.68±8.28 vs. 384.35±6.17, p<0.001) and increased the post-test RPE (rate of perceived exertion ) (7.63±1.37 vs. 12.05±1.63, p<0.001) and the post-test leg fatigue (1.71±0.88 vs. 5.28±0.91, p<0.001) compared with the control group. | |||||||||||||||||||||
202 | COVID-19 Pathophysiology: Inflammation to Cardiac Injury | 2024-12-13 | https://doi.org/10.3390/hearts5040048 | Sami Fouda | https://www.mdpi.com/2673-3846/5/4/48 | COVID-19 leads to a range of proinflammatory processes linked to myocardial injury and heart failure. Mechanisms linking COVID-19 to myocardial injury include direct viral-mediated cardiomyocyte invasion, the deleterious effects of proinflammatory environment and thromboembolic events. | |||||||||||||||||||||
203 | Histopathological Evaluation of Pulmonary Arterial Remodeling in COVID-19 | 2024-12-13 | https://doi.org/10.1101/2024.12.12.628253 | Sergiy G. Gychka | https://www.biorxiv.org/content/10.1101/2024.12.12.628253v1 | Pulmonary vascular remodeling in COVID-19 patients was associated with hypertrophy of the smooth muscle layer, perivascular fibrosis, edema and lymphostasis, inflammatory infiltration, perivascular hemosiderosis and neoangiogenesis. These results further confirm that COVID-19 affects the pulmonary vasculature and warrants an evaluation of patients that survived COVID-19 for possible future development of pulmonary arterial hypertension. | |||||||||||||||||||||
204 | Cardiac Damage in Patients Infected with Different SARS-CoV-2 Variants of Concern | 2024-12-18 | https://doi.org/10.3390/microorganisms12122617 | Francesco Robert Burkert | https://www.mdpi.com/2076-2607/12/12/2617 | In our study, we detected significantly higher levels of biomarkers for acute cardiac injury as well as chronic heart stress in patients affected by the Omicron VOC when compared to those affected by the wt/Alpha VOC, indicating that the burden of cardiac damage in Omicron infections should not be underestimated. | |||||||||||||||||||||
205 | Impacts of Moderate Severity COVID-19 on Functional Capacity, Exercise Tolerance, Muscle Strength, Hang Grip and Quality of Life | 2024-12-24 | https://doi.org/10.21203/rs.3.rs-5656328/v1 | Maha Alshammari | https://www.researchsquare.com/article/rs-5656328/v1 | Patients with COVID-19 moderate severity have impairments in functional capacity, exercise tolerance, isometric muscle strength, hand grip, and quality of life. Mean values of functional capacity, isometric muscle power, hand grip, and quality of life reduced significantly in patients with moderate COVID-19 on comparison with their matched (p-values < 0.05), except exercise tolerance (p-values > 0.05) (at least 3 months after recovering time). | |||||||||||||||||||||
206 | Temporal variations in QTc interval during and after COVID-19 infection: a retrospective study | 2024-12-23 | https://doi.org/10.1186/s12872-024-04405-w | Dasheng Lu | https://link.springer.com/article/10.1186/s12872-024-04405-w | COVID-19 infection demonstrated a significant correlation with prolonged QTc interval, persisting in the short term but gradually returning to normal in the long term. In short-term follow-up (≤ 6 months), QTc interval remained unchanged from the infectious period (p > 0.05), whereas it significantly decreased during long-term follow-up (> 6 months; 429.6 ± 32.5 ms vs. 437.5 ± 28.2 ms, p = 0.002). | |||||||||||||||||||||
207 | COVID-19 and Long-term Risk of Ischemic Heart Disease in Asthma | 2024-12-23 | https://doi.org/10.4168/aair.2025.17.1.135 | Sungmin Zo | https://e-aair.org/DOIx.php?id=10.4168/aair.2025.17.1.135 | Our study showed that even after the resolution of the acute phase of COVID-19, asthmatics who experienced severe COVID-19 showed a 2.54-fold higher long-term risk of IHD than matched patients with asthma. Among individuals with severe COVID-19, the risk of IHD was higher among females, non-obese individuals, and non-regular exercisers, although this was not statistically significant. | |||||||||||||||||||||
208 | Unlike common pneumonia, COVID-19 is a risk factor for multiple cardiovascular diseases: A two-sample Mendelian randomization study | 2024-12-27 | 10.1097/MD.0000000000041015 | Li, Chengjia | https://journals.lww.com/md-journal/fulltext/2024/12270/unlike_common_pneumonia,_covid_19_is_a_risk_factor.42.aspx | Unlike past common BP (bacterial pneumonia) or VP (viral pneumonia), COVID-19 was found to increase the risks of SA (stable angina), UA (unstable angina), HF (heart failure), and MI (myocardial infarction.) COVID-19 infection was found to enhance the incidence of SA, UA, HF, and MI (SA: odds ratio [OR], 1.12; ; UA: OR, 1.14; HF: OR, 1.12; MI: OR, 1.11). | |||||||||||||||||||||
209 | Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group | 2024-12-28 | https://doi.org/10.1038/s41598-024-82411-w | Aldair Darlan Santos-de-Araúj | https://www.nature.com/articles/s41598-024-82411-w#Sec17 | Individuals with post-COVID have an imbalance in autonomic modulation with significant impairments in HRV (Heart rate variability). Groups G1 (≤6 weeks after infection) and G2 (2–6 months) showed less parasympathetic modulation when compared to CG (Congrol Group), while G3 (7–12 months) showed an increase in parasympathetic modulation when compared to G1. | |||||||||||||||||||||
210 | Heart rate variability parameters indicate altered autonomic tone in subjects with COVID-19 | 2024-12-28 | https://doi.org/10.1038/s41598-024-80918-w | Gabriel Gruionu | https://www.nature.com/articles/s41598-024-80918-w | COVID-19 patients exhibit significant alterations in HRV (Heart Rate Variability), indicating autonomic dysfunction, characterized by decreased vagal tone and sympathetic dominance, similar to patients with severe cardiovascular comorbidities. Despite higher heart rates, the HRV analysis suggests COVID-19 is associated with substantial disruption in autonomic regulation | |||||||||||||||||||||
211 | New-onset cardiovascular diseases post SARS-CoV-2 infection in an urban population in the Bronx | 2024-12-28 | https://www.nature.com/articles/s41598-024-82983-7#citeas | Jason Y. Lu | https://www.nature.com/articles/s41598-024-82983-7 | We concluded that new incident cardiovascular disorders in COVID-19 patients, especially those hospitalized for COVID-19, were higher than those in controls. Compared to contemporary controls, hospitalized COVID-19 patients had significantly higher risk of developing MACE (aHR = 2.29), arrhythmias (aHR = 2.54), inflammatory heart disease (aHR = 5.34), cerebrovascular (aHR = 2.05), other cardiac disorders (aHR = 2.31), thrombosis (aHR = 4.25), and ischemic heart disease (aHR = 1.89). Non-hospitalized COVID-19 patients had slightly higher risk of developing MACE (aHR = 1.04), arrhythmias (aHR = 1.10), inflammatory heart disease (aHR = 2.29), cerebrovascular (aHR = 1.11), and ischemic heart disease (aHR = 1.10). | |||||||||||||||||||||
212 | Sustained Vascular Inflammatory Effects of SARS-CoV-2 Spike Protein on Human Endothelial Cells | 2024-12-31 | https://doi.org/10.1007/s10753-024-02208-x | Mitra Gultom | https://link.springer.com/article/10.1007/s10753-024-02208-x | Our study revealed that SARS-CoV-2 spike protein triggered prolonged cell adhesion marker expression and cytokine/chemokine releases, along with increased immune cell binding and formation of a procoagulant state of the ECs (endothelial cells). We also showed that on the transcriptome level, SARS-CoV-2 spike resulted in sustained inflammation, changes in antigen presentation, and coagulation state of the endothelium. The observed prolonged effects beyond the presence of the spike protein suggests possible long-term consequences of SARS-CoV-2 on the endothelium. | |||||||||||||||||||||
213 | Risk impact of SARS-CoV-2 coronavirus and spike protein on cardiac tissue: a comprehensive review | 2024-12-31 | https://doi.org/10.33549/physiolres.935476 | O Šerý | In conclusion, SARS-CoV-2 has a profound and multifaceted impact on cardiac tissue, mediated primarily through the Spike protein's interaction with the ACE2 receptor. The virus not only causes direct damage to the heart by infecting cardiomyocytes but also triggers significant systemic effects that can exacerbate preexisting cardiovascular conditions. The extensive expression of ACE2 in heart cells underpins the high susceptibility of cardiac tissues to SARS-CoV-2, leading to a range of complications from myocarditis to severe myocardial dysfunction. | ||||||||||||||||||||||
214 | A pilot study comparing the rehabilitation functional outcomes of post-COVID-19 stroke and non-COVID stroke patients: An occupational therapy perspective | 2024-12-31 | https://doi.org/10.5339/qmj.2024.70 | PMC11806636 | Thajus Asirvatham | Both the post-COVID-19 stroke and non-COVID stroke groups showed significant differences before and after rehabilitation. However, the mean difference in the non-COVID-19 stroke group was higher than that in the post-COVID-19 stroke group, particularly in MMSE, FIM, and NIHSS scores | |||||||||||||||||||||
215 | SARS-CoV-2 spike protein activates NOX2-p66SHC axis via inhibiting SLAMF8 to promote thrombogenesis | 2025-01-03 | https://doi.org/10.21203/rs.3.rs-5572297/v1 | Quan Liu | Our study demonstrates that that the SARS-CoV-2 S protein suppresses SLAMF8 expression, thereby activating the NOX2-p66SHC axis. This activation induces a sustained increase in ROS (reactive oxygen species production(, disrupts mitochondrial dynamics, and results in endothelial cell damage and thrombosis. | ||||||||||||||||||||||
216 | Elevated Atherogenicity in Long COVID: A Systematic Review and Meta-Analysis | 2025-01-06 | https://doi.org/10.1101/2025.01.06.25320068 | Abbas F. Almulla | https://www.medrxiv.org/content/10.1101/2025.01.06.25320068v1 | LC is linked to increased atherogenicity and reduced anti-atherogenic potential, confirming its role as a pro-atherogenic condition that may lead to serious cardiovascular complications. LC patients exhibited significant elevations in Castelli Risk Indexes 1 (standardized mean difference, SMD = 0.199) and 2 (SMD = 0.202). Atherogenic ratios, including triglyceride (TG)/high-density lipoprotein (HDL) (SMD = 0.294) and ApoB/ApoA (SMD = 0.515), were also significantly elevated. | |||||||||||||||||||||
217 | Long-Term Effects of COVID-19 on Optic Disc and Retinal Microvasculature Assessed by Optical Coherence Tomography Angiography | 2025-01-06 | https://doi.org/10.3390/diagnostics15010114 | Mine Ozturk | https://www.mdpi.com/2075-4418/15/1/114 | Our study demonstrated long-lasting retinal vascular alterations even after 1 year in recovered COVID-19 patients. Should persistent microvascular alterations be observed in the retina after 12 months, it can be inferred that other organs and their vascular networks may have long-term damage. | |||||||||||||||||||||
218 | Association of Pulmonary Involvement at Baseline with Exercise Intolerance and Worse Physical Functioning 8 Months Following COVID-19 Pneumonia | 2025-01-13 | https://doi.org/10.3390/jcm14020475 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11765862/ | Fatma Isil Uzel | https://pubmed.ncbi.nlm.nih.gov/39860481/ | One-third of participants experienced exercise intolerance eight months after COVID-19 pneumonia. | ||||||||||||||||||||
219 | Cardiac Hemodynamics, Tissue Oxygenation, and Functional Capacity in Post-COVID-19 Patients | 2025-01-14 | https://doi.org/10.3390/medicina61010124 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11766540/ | Elizane Poquiviqui do Nascimento | https://pubmed.ncbi.nlm.nih.gov/39859106/ | The post-COVID-19 subjects exhibited a reduction in functional capacity, changes in hemodynamic responses related to cardiac and systemic vascular resistance, and a similar pattern of muscle oxygen delivery and consumption in both tests. The post-COVID-19 group showed a 20% decrease in 6MWT (six-minute walk test) distance and a 28% decrease in 1-STS (one-minute sit-stand test) repetitions versus the control group. Cardiac hemodynamic differences were observed in the post-COVID-19 group during the 1-STS, with reductions in the stroke volume index, cardiac index, Contractility Index, and Ejection Fraction and increases in Systemic Vascular Resistance and the Systemic Vascular Resistance Index. | ||||||||||||||||||||
220 | Abstract 181: Acute Ischemic Stroke And Endovascular Thrombectomy During COVID‐19 Pandemic: A Nationwide Analysis | 2025-01-15 | https://doi.org/10.1161/SVIN.04.suppl_1.181 | P. Reddi | https://www.ahajournals.org/doi/abs/10.1161/SVIN.04.suppl_1.181 | The presence of COVID‐19 in AIS (acute ischemic stroke) patients was significantly associated with a higher rate of inpatient mortality (AOR:2.79; 95% CI[2.61‐2.98]; p<0.001) and a lower rate of favorable hospital outcome (AOR:0.66; 95% CI[0.62‐0.70]; p<0.001). | |||||||||||||||||||||
221 | Attenuated cardiac autonomic function in patients with long-COVID with impaired orthostatic hemodynamics | 2025-01-22 | https://doi.org/10.1007/s10286-025-01107-x | Rashmin Hira | https://link.springer.com/article/10.1007/s10286-025-01107-x | Patients with long-COVID have attenuated cardiac autonomic function. Patients with long-COVID had lower upright high frequency heart rate variability (p = 0.04) and low frequency blood pressure variability (p = 0.001) than controls. | |||||||||||||||||||||
222 | Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis | 2025-01-28 | https://doi.org/10.3389/fcvm.2025.1450470 | Ting Zhang | https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1450470/full | The risk of cardiovascular disease increased significantly four weeks or more after recovering from acute COVID-19. Long COVID-19 was associated with a higher risk of thromboembolic disorders [HR 3.12], coronary heart disease [HR 1.61], stroke [HR 1.71], arrhythmia [HR 1.60], cardiomyopathy [HR 1.71], myocarditis [HR 6.11], hypertension [HR 1.70], heart failure [HR 1.72] and cardiogenic shock [HR 2.09] compared to non-COVID-19 controls. | |||||||||||||||||||||
223 | Assessment of cardiac structure and function 1.5 years after COVID-19: results from the EPILOC study | 2025-01-29 | https://doi.org/10.1093/ehjci/jeae333.266 | J Schellenberg | https://academic.oup.com/ehjcimaging/article/26/Supplement_1/jeae333.266/7986491?login=false | Significantly reduced cardiac function in PCS (post-COVID syndrome) compared to CON (control patients) 1.5 years after SARS-CoV-2 infection could indicate long-term left myocardium involvement, while signs of RV involvement were inconsistent. PCS showed lower LV GLS (-20.25% vs. -20.73%, p=0.003), diastolic function (E/A 1.16 vs. 1.21, p=0.022) and TAPSE (24.45 vs. 25.05, p=0.022) compared to CON, while RV strain values did not differ. LV GLS was negatively associated with VO2max (p=0.004) and positively associated with rapid physical exhaustion (p=0.050), but not with cardiopulmonary symptoms. | |||||||||||||||||||||
224 | Subclinical patterns of cardiac involvement by transthoracic echocardiography in individuals with mild initial COVID-19 | 2025-01-30 | https://doi.org/10.1038/s41598-025-85221-w | Anastasia Shchendrygina | https://www.nature.com/articles/s41598-025-85221-w | In the present cohort of COVID-19-infected individuals with mild initial illness, echocardiographic measurements revealed significant yet subclinical differences in systolic and diastolic function compared with controls, as well as between individuals with cardiac symptoms and those without. Compared with those at baseline, there was a reduced systolic GLS (global longitudinal strain), worsening diastolic function, and no change in LVEF (LV ejection fraction) or TAPSE (tricuspid annular plane systolic excursion) at follow-up. Symptomatic individuals had higher heart rates at baseline and follow-up. | |||||||||||||||||||||
225 | Native T1 is independently predictive of aerobic functional capacity by VO2max in long-term follow-up of individuals with mild initial COVID disease | 2025-01-30 | https://doi.org/10.1016/j.jocmr.2024.101455 | Monika Rozewicz | https://www.sciencedirect.com/science/article/pii/S1097664724014820?via%3Dihub | In individuals with no previously known structural heart disease and mild initial COVID-19 illness, age, female sex, LV volumes, RVEF (Right Ventricular Ejection Fraction), native T1 and E/e were univariable predictors of VO2 max (maximal oxygen consumption) in long-term follow-up. In multivariable analysis, native T1 was the sole independent predictor of VO2 max at follow-up. About a third (28%) had persistent myocardial LGE (late gadolinium enhancement). | |||||||||||||||||||||
226 | Predictors of Cardiovascular Symptoms Among Long COVID Patients: Data from the Polish Long COVID Cardiovascular (PoLoCOV-CVD) Study | 2025-02-02 | https://doi.org/10.3390/jcm14030956 | Joanna Kapusta | https://www.mdpi.com/2077-0383/14/3/956 | The significant positive association of female gender and sleep disturbances with cardiovascular complications during Long COVID highlights critical demographic and psychological factors that deserve attention in clinical practice. Cardio-LC patients had statistically significant differences relative to the non-LC group in terms of blood pressure, elevated LDL cholesterol (p = 0.010), and non-HDL cholesterol (p = 0.013). | |||||||||||||||||||||
227 | A model-based spectral directional approach reveals the long-term impact of COVID-19 on cardiorespiratory control and baroreflex | 2025-02-03 | https://doi.org/10.1186/s12938-024-01327-8 | Beatrice Cairo | https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/s12938-024-01327-8 | CK2 (causal squared coherence) markers, in association with an orthostatic challenge, were able to characterize the impairment of cardiorespiratory control and baroreflex in COVID-19 patients long after acute infection resolution. Dysautonomia is present 9 months after hospital discharge and even in COVID-19 patients featuring the lowest degree of severity during hospitalization, namely the noCPAP group (no need of continuous positive airway pressure). | |||||||||||||||||||||
228 | SARS-CoV-2 Infection Association with Atherosclerotic Plaque Progression at Coronary CT Angiography and Adverse Cardiovascular Events | 2025-02-04 | https://doi.org/10.1148/radiol.240876 | Neng Dai | https://pubs.rsna.org/doi/10.1148/radiol.240876#_i9 | SARS-CoV-2 infection was associated with a more rapid progression of lesion-based plaque volume and an increase in incidence of becoming high-risk plaque. The incidence of becoming high-risk plaque (21.0% vs 15.8%) and PCAT attenuation of −70.1 HU or higher (27.1%vs 19.8%) at follow-up was also greater in lesions in patients with SARS-CoV-2 infection (P < .001), despite similar prevalence at baseline. Lesions in patients with COVID-19 had a higher risk of target lesion failure (10.4% vs 3.1%, respectively; adjusted hazard ratio, 2.90). | |||||||||||||||||||||
229 | Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis | 2025-02-06 | https://doi.org/10.1186/s12916-025-03908-3 | Li-wei Huang | https://link.springer.com/article/10.1186/s12916-025-03908-3 | Our findings indicate that 15% of COVID-19 patients experience cardiovascular sequelae. Furthermore, COVID-19 infection significantly increases the likelihood of developing these sequelae compared to uninfected individuals. The ORs of chest pain in the COVID-19 group was 4.0 (95% CI: 1.6, 10.0). The ORs for palpitation and hypertension were 3.4 (95% CI: 1.1, 10.2) and 1.7 (95% CI: 1.6, 1.8), respectively. | |||||||||||||||||||||
230 | Longitudinal epigenetic rewiring in lung immune cells in patients with post-COVID-19 condition | 2025-02-07 | https://doi.org/10.1101/2025.02.06.25321750 | Frida Nikesjö | https://www.medrxiv.org/content/10.1101/2025.02.06.25321750v1 | We identified longitudinal DNAm changes in lung immune cells associated with pathways linked to cardiac function. These changes correlate with symptom burden and heart and lung metrics. We determined a significant association between COVID-19-induced DNAm changes and the symptom-physiology score, which mapped to biological pathways related to cardiac function. | |||||||||||||||||||||
231 | COVID-19 Related Retinal Vascular Occlusion: A Systematic Review | 2025-02-11 | https://doi.org/10.3390/jcm14041183 | Argyrios Tzamalis | COVID-19 seems to play a significant role in the pathogenesis of vascular occlusion, as it is suggested to increase the risk of thromboembolic episodes. Fifteen out of the twenty-one patients (71.4%) with RVO had a significant improvement in visual acuity after the resolution of symptoms while eight out of the fifteen patients (53.3%) with RAO did not show improvement. | ||||||||||||||||||||||
232 | The effect of COVID-19 on cardiovascular function and exercise tolerance in healthy middle-age and older individuals | 2025-02-14 | https://doi.org/10.1080/14017431.2025.2468339 | Sophie L. Russell | https://www.tandfonline.com/doi/full/10.1080/14017431.2025.2468339 | Healthy middle-age and older individuals with history COVID-19 infection demonstrate reduced exercise tolerance and cardiac function response to exercise.COVID-19 participants however demonstrated lower O2 consumption at anaerobic threshold (15.5 ± 4.25 vs 16.8 ± 4.51 mL/kg/m2, p = 0.034), peak cardiac index (10.4 ± 2.3 vs 11.3 ± 2.5 L/min/m2, p = 0.040) and peak stroke volume index (82.1 ± 25.3 vs 98.6 ± 37.6 mL/m2, p = 0.028). | |||||||||||||||||||||
233 | Non-Hospitalized Long COVID Patients Exhibit Reduced Retinal Capillary Perfusion: A Prospective Cohort Study | 2025-02-17 | https://doi.org/10.3390/jimaging11020062 | Clayton E. Lyons | https://www.mdpi.com/2313-433X/11/2/62 | Neuro-PASC patients (N = 30; 60 eyes) exhibited a statistically significant (p = 0.005) reduction in DCP VLD compared to healthy controls (N = 44; 80 eyes). The sole reduction in DCP (deep capillary plexus) VLD (vessel length density) in Neuro-PASC may suggest preferential involvement of the smallest blood vessels. | |||||||||||||||||||||
234 | Left ventricular assessment by 3D-echocardiography in post-COVID-19 syndrome | 2025-02-18 | https://doi.org/10.1007/s44349-025-00015-3 | Wael Samy | https://link.springer.com/article/10.1007/s44349-025-00015-3 | Our study findings suggest that persons who developed symptoms such as difficulty breathing, rapid heartbeat, or chest pain following their recovery from COVID-19 exhibited a reduction in left ventricular global longitudinal strain (LV-GLS) as measured by three-dimensional echocardiography (3DE). Subclinical myocardial dysfunction, as shown by a decrease in left ventricular global longitudinal strain (LV-GLS), is common in over 85% of patients with post-COVID-19 syndrome. | |||||||||||||||||||||
235 | Circulating Autoantibodies Against Vasoactive Biomarkers Related to Orthostatic Intolerance in Long COVID Patients Compared to No-Long-COVID Populations: A Case-Control Study | 2025-02-18 | https://doi.org/10.3390/biom15020300 | Emilie Han | https://www.mdpi.com/2218-273X/15/2/300 | A strong trend (p < 0.1) towards elevated Beta-2 AR and Ang1-7 was observed in long COVID patients, however, irrespective from the presence of orthostatic intolerance. In long COVID patients elevated autoantibodies against ETAR (endothelin type A receptor) correlated with more symptoms in performing usual daily activities. | |||||||||||||||||||||
236 | Long-Term Effects of COVID-19 on Cardiovascular System and the Risk Markers: A Systematic Review | 2025-02-22 | https://doi.org/10.1007/s42399-025-01805-7 | Zinat Nadia Hatmi | https://link.springer.com/article/10.1007/s42399-025-01805-7 | Long COVID-19 CVD (cardiovascular disease) manifestations after 12 weeks of follow-up demonstrated the strongest hazard ratios for atrial fibrillation, ischemic heart disease, heart rate variability, heart failure, pericarditis, myocardial infarction, thrombotic events, ventricular fibrillation, ischemic cardiomyopathy, fatigue, coronary artery disease, DM, and HTN. The systematic review results indicate that the incidence of cardiovascular manifestations and risk factors have significantly increased after 12 weeks of COVID-19. | |||||||||||||||||||||
237 | Integrated multiomics reveals alterations in paucimannose and complex type N-glycans in cardiac tissue of COVID-19 patients | 2025-02-22 | https://doi.org/10.1016/j.mcpro.2025.100929 | Sabarinath Peruvemba Subramanian | https://www.sciencedirect.com/science/article/pii/S1535947625000271 | We observed changes in N-glycan structure abundance that occur in the human heart post-COVID-19. Major changes in paucimannose and complex structures were observed in COVID(+) cardiac tissues. Our observations suggest that SARS-CoV-2 infection primes cardiac cells to alter the glycome at all levels, namely metabolism, transport of nucleotide sugar, and glycosyltransferases with an overall trend to favor synthesis and reduce degradation. | |||||||||||||||||||||
238 | Cardiac structure and function 1.5 years after COVID-19: results from the EPILOC study | 2025-02-24 | https://doi.org/10.1007/s15010-025-02481-4 | Jana Schellenberg | https://link.springer.com/article/10.1007/s15010-025-02481-4 | This study demonstrates subtle yet consistent reductions in LV (left ventricular) function, specifically LV GLS and diastolic function, and exercise capacity in PCS (post-Coronavirus disease syndrome) compared to CON (recovered controls). PCS participants exhibited significantly lower LV GLS, reduced diastolic function and decreased TAPSE compared to CON, even after adjusting for confounders. | |||||||||||||||||||||
239 | Speckle-tracking and conventional echocardiography in MIS-C: tracking cardiac involvement and recovery | 2025-02-25 | https://doi.org/10.1186/s12887-025-05509-8 | Nima Mehdizadegan | https://link.springer.com/article/10.1186/s12887-025-05509-8 | Cardiac dysfunction in MIS-C largely resolves within three months, with LVEF and GLS returning to normal. However, persistent myocardial abnormalities in a few cases highlight the need for long-term cardiac monitoring to detect and manage potential sequelae. | |||||||||||||||||||||
240 | Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort | 2025-02-26 | https://doi.org/10.3389/fcvm.2025.1462263 | Chang Liu | https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1462263/full | Our findings suggest subtle cardiac changes associated with SARS-CoV-2 antibody positivity within approximately hundred days. Native T1 values appeared to be elevated in seropositive participants. Logistic regression analysis in the overall cohort indicated an association between SARS-CoV-2 antibody positivity and an increased risk of LV (left ventricular) hypertrophy, with an adjusted odds ratio of 3.257 [95% CI (1.036–10.239), P = 0.043]. | |||||||||||||||||||||
241 | Longer-term effects of SARS-CoV-2 infection on blood vessels and blood pressure | 2025-02-26 | https://doi.org/10.5525/gla.thesis.84929 | Stefanie Zhao Lin Lip | https://theses.gla.ac.uk/84929/ | There was a significant rise in blood pressure among recovered COVID-19 patients, with systolic pressure increasing by 4.57 mmHg and diastolic by 4.46 mmHg over 12 months compared to controls. A 3.15% reduction in flow-mediated dilation (FMD) suggested endothelial dysfunction. The observed blood pressure rise, and potential endothelial dysfunction post-recovery indicate the need for vigilant cardiovascular monitoring. |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 39 | |||||||||||||||||||||||||
3 | SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus | 2021-06-03 | https://doi.org/10.1038/s42003-021-02220-z | Jungang Chen | https://www.nature.com/articles/s42003-021-02220-z | We report that SARS-CoV-2 encoded proteins and some currently used anti-COVID-19 drugs are able to induce lytic reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV), one of major human oncogenic viruses, through manipulation of intracellular signaling pathways. Our data indicate that those KSHV + patients especially in endemic areas exposure to COVID-19 or undergoing the treatment may have increased risks to develop virus-associated cancers, even after they have fully recovered from COVID-19. | |||||||||||||||||||||
4 | The risk of pancreatic adenocarcinoma following SARS-CoV family infection | 2021-06-21 | https://doi.org/10.1038/s41598-021-92068-4 | Amin Ebrahimi Sadrabadi | https://www.nature.com/articles/s41598-021-92068-4 | This research showed that infection with the SARS-CoV family may increase the risk of the cancer development by altering the expression of various oncoproteins. Our findings suggest the pancreatic adenocarcinoma as the most possible malignancy occurring after sever infection with SARS-CoV family. | |||||||||||||||||||||
5 | The network of SARS-CoV-2—cancer molecular interactions and pathways | 2022-04-05 | https://doi.org/10.1101/2022.04.04.487020 | Pau Erola | https://www.biorxiv.org/content/10.1101/2022.04.04.487020v1 | The long-term implications of SARS-CoV-2 infection are still unknown, but our results point to the potential impact of infection on pathways relevant to cancer affecting cell proliferation, development and survival, favoring DNA degradation, preventing the repair of damaging events and impeding the translation of RNA into working proteins. | |||||||||||||||||||||
6 | Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme | 2022-04-05 | https://doi.org/10.3389/fimmu.2022.840785 | Anjing Chen | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.840785/full | The expression pattern and survival analysis of six receptors in GBM (Glioblastoma multiforme) demonstrated that the upregulation of ANPEP and ENPEP is associated with poor survival of GBM. The distribution of ANPEP and ENPEP in endothelial cells of the blood–brain barrier provides the place for SARS-CoV-2 cell entry into the brain, and the potential binding of ANPEP or ENPEP to RBD by protein–protein docking offers tools for SARS-CoV-2 infection, which in turn contributes to the increased susceptibility of GBM to SARS-CoV-2 | |||||||||||||||||||||
7 | Novel evidence revealed genetic association between COVID-19 infection, severity and endometrial cancer | 2022-05-20 | https://doi.org/10.1016/j.jinf.2022.05.005 | PMC9088088 | Xiangrong Wu | https://www.journalofinfection.com/article/S0163-4453(22)00261-4/fulltext | The primary MR analyses results suggested that the reported SARS-CoV-2 infection (odds ratio (OR) = 1.165, 95% confidence interval (CI) 1.012–1.340, P = 0.033), hospitalized COVID-19 (OR 1.145, 95% CI 1.002–1.309, P = 0.047), and critically ill COVID-19 (OR 1.075, 95% CI 1.006–1.148, P = 0.032) had a significant positive correlation with the risk of endometrial cancer | ||||||||||||||||||||
8 | SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells | 2022-06-07 | https://doi.org/10.3389/fonc.2022.923467 | Hoai-Nga Thi Nguyen | https://www.frontiersin.org/articles/10.3389/fonc.2022.923467/full | The results suggested that SARS-CoV-2 M protein induced the mobility, proliferation, stemness and in vivo metastasis of a triple-negative breast cancer (TNBC) cell line. These findings suggested an increased risk of poor outcomes in TNBC patients with a history of SARS-CoV-2 infection, which required a long-term follow-up. | |||||||||||||||||||||
9 | SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells | 2022-06-07 | https://doi.org/10.3389/fonc.2022.923467 | Hoai-Nga Thi Nguyen | https://www.frontiersin.org/articles/10.3389/fonc.2022.923467/full | The results suggested that SARS-CoV-2 M protein induced the mobility, proliferation, stemness and in vivo metastasis of a triple-negative breast cancer (TNBC) cell line, MDA-MB-231, which are involved in the upregulation of NFκB and STAT3 pathways. these findings suggested an increased risk of poor outcomes in TNBC patients with a history of SARS-CoV-2 infection, which required a long-term follow-up. | |||||||||||||||||||||
10 | Cancer related-genes enriched in peripheral blood mononuclear cells (PBMCs) of COVID-19 patients. a bioinformatics study | 2022-08-02 | https://doi.org/10.21203/rs.3.rs-1894265/v1 | Ehsan Ahmadi | https://www.researchsquare.com/article/rs-1894265/v1 | The analysis showed that numerous cancer-related genes up-regulated in SARS-CoV-2 infected patients, particularly those genes participating in the cell cycle regulation or engaged in cellular senescence processes.Our findings suggest that SARS-CoV-2 can be considered a potential risk factor for increasing the probability of developing cancer. | |||||||||||||||||||||
11 | Is SARS-CoV-2 an oncogenic virus? | 2022-08-09 | https://doi.org/10.1016/j.jinf.2022.08.005 | PMC9361571 | Alberto Gómez-Carballa | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361571/ | We examine three gene expression datasets to demonstrate that p53 is downregulated during acute SARS-CoV-2 infection and long coronavirus-disease 19 (COVID-19); a long-term reduction of p53 could be interpreted as a risk factor in carcinogenesis. | ||||||||||||||||||||
12 | COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis | 2022-11-09 | https://doi.org/10.1016/j.jri.2022.103763 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9645588/ | Sabeth Becker | https://pubmed.ncbi.nlm.nih.gov/36399874/ | Our results hint at an indirect effect of COVID-19 on the cervical neoplasm. We conclude that the immune system might be preoccupied and exhausted by the concurring COVID-19 disease, leading to less immunological pressure on the HPV-infected cervical dysplasia enabling rapid disease progression. | ||||||||||||||||||||
13 | SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma | 2023-01-03 | https://doi.org/10.1371/journal.pone.0279578 | Oi Kuan Choong | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279578 | Our data provide insights into SARS-CoV-2 infectivity in renal cell carcinoma and that the virus causes a distinct cytopathogenic effect. SARS-CoV-2 virus propagated robustly in primary cultures of CCRCC (cancers derived from proximal tubules as clear cell) and PRCC (papillary renal cell carcinoma) cells with a visible virus cytopathogenic effect correlating with viral RNA expression levels. We also noted that the delta-variant of SARS-CoV-2 causes cancer cells to form syncytia in-vitro. | |||||||||||||||||||||
14 | Causal effects of COVID-19 on cancer risk: A Mendelian randomization study | 2023-04-16 | https://doi.org/10.1002/jmv.28722 | Jia Li | https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28722 | The present study suggested that the genetic liability to critically ill COVID-19, hospitalized COVID-19, and SARS-CoV-2 infection may increase the risk for gastrointestinal cancers and HER2-positive breast cancer. | |||||||||||||||||||||
15 | Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent? | 2023-05-23 | https://doi.org/10.1016/j.biochi.2023.05.014 | Kasra Jahankhani | https://www.sciencedirect.com/science/article/pii/S0300908423001360 | Since infection with SARS-CoV-2 occurs in several organs either directly or indirectly, it is expected that cancer stem cells may develop in multiple organs. It is important to note that the cancer-related effects of SARS-CoV-2 proposed in this article are based on the ability of the virus and its proteins to cause cancer but that the long-term consequences of this infection will only be illustrated in the long run. | |||||||||||||||||||||
16 | COVID−19 hospitalization increases the risk of developing glioblastoma: a bidirectional Mendelian-randomization study | 2023-08-21 | https://doi.org/10.3389/fonc.2023.1185466 | Jiajun Dong | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1185466/full | Our results showed that genetically predicted COVID−19 hospitalization increases the risk of GBM (OR = 1.202, 95% CI = 1.035–1.395, p = 0.016). | |||||||||||||||||||||
17 | SARS-CoV-2 infection as a potential risk factor for the development of cancer | 2023-09-11 | https://doi.org/10.3389%2Ffmolb.2023.1260776 | Natalia Ogarek | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518417/ | SARS-CoV-2 exploits host immunity stimulates signalling and oncogenic pathways and may establish an oncogenic microenvironment. Persons with clinically recovered COVID-19 show profound immune alterations that persist for several months after hospital discharge. The virus has been shown not only to affect cancer progression but also to induce oncogenesis and cancer recurrence. | |||||||||||||||||||||
18 | Causality between COVID-19 and multiple myeloma: a two-sample Mendelian randomization study and Bayesian co-localization | 2024-02-24 | https://doi.org/10.1007/s10238-024-01299-y | Shuaiyuan Wang | https://link.springer.com/article/10.1007/s10238-024-01299-y | We show for the first time that SARS-CoV-2 infection and COVID-19 hospitalization are associated with a higher risk of MM (multiple myeloma) genetically. Our results support the conclusion that COVID-19 may trigger autoimmunity and induce autoimmune diseases | |||||||||||||||||||||
19 | Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression | 2024-03-06 | https://doi.org/10.3389/fonc.2024.1346312 | Hoai-Nga Thi Nguyen | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1346312/full | Our findings suggest that triple-negative BCC (breat cancer cells) induced by M-protein produced EV (extracellular vesicles) with a higher ability to promote the functions of tissue stem cells, supporting cancer growth and aggressiveness. Our study suggests that SARS-CoV-2 infection in breast cancer patients not only promotes the aggressiveness of BCC themselves, but also the ability of BCC to manipulate the surrounding TME (tumor microenvironment). | |||||||||||||||||||||
20 | Association between COVID 19 exposure and expression of malignant pathological features in oral squamous cell carcinoma: A retrospective cohort study | 2024-04-01 | https://doi.org/10.1016/j.oraloncology.2024.106740 | Yufei Hua | https://www.sciencedirect.com/science/article/abs/pii/S1368837524000587 | COVID 19 may suggest more invasive malignant biological behavior of cancer cells in OSCC. The expression of Ki67 (n = 57, 71.3 %, P < 0.001) and CyclinD1 (n = 64, 80 %, P < 0.001) in OSCC with the exposure history of COVID 19 is higher than that in patients never exposed to COVID 19. COVID 19 exposure history is an independent influencing factor for higher expression of Ki67 (OR = 4.04, 95 % CI: 1.87–8.72, P < 0.001) and CyclinD1 (OR = 5.45, 95 % CI: 2.56–11.60, P < 0.001). | |||||||||||||||||||||
21 | Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs | 2024-04-05 | https://doi.org/10.21203/rs.3.rs-4210090/v1 | Shi B. Chia | https://www.researchsquare.com/article/rs-4210090/v1 | SARS-CoV-2 infected mice also showed increased breast DCC (disseminated cancer cells) expansion in lungs post-infection. Expanding our findings to human observational data, we observed that cancer survivors contracting a SARS-CoV-2 infection have substantially increased risks of lung metastatic progression and cancer-related death compared to cancer survivors who did not. | |||||||||||||||||||||
22 | Accelerated tumor progression after COVID-19 infection in patients with glioblastoma: a retrospective case-control study | 2024-04-08 | https://doi.org/10.1093/nop/npae029 | Timothy A Gregory | https://academic.oup.com/nop/advance-article/doi/10.1093/nop/npae029/7642126?login=false | Patients with glioblastoma may have accelerated disease progression in the first 2 months after COVID-19 infection.Hyperprogression was identified in 13 cases (48%) but only 4 controls (9%; p=0·0001). Cases had disease progression at a median of 35 days following COVID-19 testing, compared with 164 days for controls (p=0·0001). Median survival from COVID-19 testing until death was 8·3 months for cases but 17 months for controls (p=0·0016). | |||||||||||||||||||||
23 | SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells | 2024-04-15 | https://doi.org/10.1101/2024.04.12.589252 | Shengliang Zhang | https://www.biorxiv.org/content/10.1101/2024.04.12.589252v1 | The suppressive effect of SARS-CoV-2 spike on p53-dependent gene activation provides a potential molecular mechanism by which SARS-CoV-2 infection may impact tumorigenesis, tumor progression and chemotherapy sensitivity. As loss of p53 function is a known driver of cancer development and confers chemo-resistance, our study provides insight into cellular mechanisms by which SARS-CoV-2 spike S2 may be involved in reducing barriers to tumorigenesis during and post SARS-CoV-2 infections. | |||||||||||||||||||||
24 | Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure | 2024-05-03 | https://doi.org/10.18632/oncotarget.28582 | Shengliang Zhang | https://www.oncotarget.com/article/28582/text/ | We identified the SARS-CoV-2 spike as a COVID-19 virus factor that interrupts p53 binding to MDM2 in cancer cells and demonstrated the suppressive effect of SARS-CoV-2 spike on p53 signaling in cancer cells. As loss of p53 function is a known driver of cancer development and confers chemo-resistance, our study provides insight into cellular mechanisms by which SARS-CoV-2 spike may be involved in reducing barriers to tumorigenesis during and post SARS-CoV-2 infections. | |||||||||||||||||||||
25 | Impact of in vitro SARS-CoV-2 infection on breast cancer cells | 2024-06-07 | https://doi.org/10.1038/s41598-024-63804-3 | Michele Sommariva | https://www.nature.com/articles/s41598-024-63804-3 | We found that MCF7 cells were the most permissive to viral replication. A metagene signature based on genes upregulated by SARS-CoV-2 infection in all three cell lines distinguished a subgroup of premenopausal luminal A breast cancer patients with a poor prognosis. Showing that the genes modulated by SARS-CoV-2 infection characterize a subgroup of luminal A breast cancer patients who experience worse outcomes, we want to emphasize the need to monitor the long-term impact of COVID-19 on breast cancer outcomes, particularly in premenopausal women. | |||||||||||||||||||||
26 | TMPRSS2 is a tumor suppressor and its downregulation promotes antitumor immunity and immunotherapy response in lung adenocarcinoma | 2024-06-11 | https://doi.org/10.1186/s12931-024-02870-7 | Zhixian Liu | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-024-02870-7 | TMPRSS2, a key molecule for SARS-CoV-2 invading human host cells, has an association with cancer. TMPRSS2 downregulation correlated with increased proliferation, stemness, genomic instability, tumor progression, and worse survival in LUAD (lung adenocarcinoma). Our data provide a potential link between lung cancer and pneumonia caused by SARS-CoV-2 infection. | |||||||||||||||||||||
27 | COVID-19 and Carcinogenesis: Exploring the Hidden Links | 2024-08-31 | 10.7759/cureus.68303 | Özgür Tanrıverdi | https://www.cureus.com/articles/289494-covid-19-and-carcinogenesis-exploring-the-hidden-links#!/ | Our findings highlight the need for increased cancer surveillance in COVID-19 survivors. In the post-COVID-19 period, it can be thought that inflammation associated with excessive cytokine release, especially interleukin-6, genetic and epigenetic changes, and co-infections with oncogenic viruses such as Epstein-Barr virus or human papillomavirus may be effective in the development and progression of cancer. | |||||||||||||||||||||
28 | Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways | 2024-09-26 | https://doi.org/10.1186/s12964-024-01818-0 | Aishwarya Jaiswal | https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01818-0 | SARS-CoV-2 possesses oncogenic potential, impacting multiple hallmarks of cancer through its proteins and interactions with cellular pathways. Unlike classical oncogenic viruses, which transform cells through viral oncogenes or by activating host oncogenes, SARS-CoV-2 appears to promote tumorigenesis by inhibiting tumor suppressor genes and pathways while activating survival, proliferation, and inflammation-associated signaling cascades | |||||||||||||||||||||
29 | Transient MRI changes and neurological deterioration in glioblastoma upon SARS-CoV-2 infection | 2024-09-28 | https://doi.org/10.1007/s00432-024-05963-4 | Thomas Zeyen | https://link.springer.com/article/10.1007/s00432-024-05963-4 | The results indicate a possible association between clinically relevant changes in GBM (glioblastoma ) biology and SARS-CoV-2 infection, with histological confirmation of SARS-CoV-2-associated changes within the tumor tissue. | |||||||||||||||||||||
30 | Common pathogenic mechanisms for COVID-19 and differentiated thyroid cancer: a proteomic analysis | 2024-09-29 | https://doi.org/10.1101/2024.09.28.24314528 | Hanqing Liu | https://www.medrxiv.org/content/10.1101/2024.09.28.24314528v1 | The current study revealed common pathogenic mechanisms of COVID-19 and differentiated thyroid cancer. The concomitant infection of SARS-CoV-2 might exert adverse effects on patients with thyroid cancers. | |||||||||||||||||||||
31 | In vitro analysis suggests that SARS-CoV-2 infection differentially modulates cancer-like phenotypes and cytokine expression in colorectal and prostate cancer cells | 2024-10-19 | https://doi.org/10.1038/s41598-024-75718-1 | Alberta Serwaa | https://www.nature.com/articles/s41598-024-75718-1 | Our results suggest that SARS-CoV-2 infection does influence various cancer cellular phenotypes and expression of molecular cancer markers and proinflammatory cytokines, albeit in a cell-type-specific manner. We show that SARS-CoV-2 infection impacts several key cellular pathways involved in cell growth, apoptosis, and migration, in prostate and colorectal cancer cells. | |||||||||||||||||||||
32 | Linking COVID-19 and cancer: Underlying mechanism | 2024-11-07 | https://doi.org/10.1016/j.bbadis.2024.167563 | Sourabh Tyagi | https://www.sciencedirect.com/science/article/abs/pii/S092544392400557X | SARS-CoV-2 infection might increase cancer susceptibility and accelerate cancer progression through mechanisms involving cytokine storm, tissue hypoxia, impaired T-cell responses, autophagy, neutrophil activation, and oxidative stress. These mechanisms collectively contribute to immune suppression, hindered apoptosis, and altered cellular signaling in the tumor microenvironment, creating conditions favorable for tumor growth, metastasis, and recurrence. | |||||||||||||||||||||
33 | Reactive oxygen species induced by SARS-CoV-2 infection can induce EMT in solid tumors: potential role of COVID-19 in chemo-resistance and metastasis | 2024-11-08 | https://doi.org/10.1016/j.heliyon.2024.e40297 | Melina Moulaeian | https://www.sciencedirect.com/science/article/pii/S2405844024163281 | In conclusion, this review proposes a potential role of SARS-CoV-2 in EMT (epithelial-mesenchymal transition) induced by ROS (reactive oxygen species) and related increased risk of chemo-resistance and metastasis in solid tumors. | |||||||||||||||||||||
34 | Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link | 2024-12-06 | https://doi.org/10.3390/pathogens13121070 | Abdelbasset Amara | https://www.mdpi.com/2076-0817/13/12/1070 | A definitive link established between COVID-19 and lung cancer is still elusive. The evidence of long-term respiratory sequelae, perpetual and persistent inflammation, and, finally, the molecular pathways initiated and triggered by SARS-CoV-2 suggest a probable association and a potential link. | |||||||||||||||||||||
35 | A comprehensive pan-cancer analysis of SARS-CoV-2-related cancer malignancy: COVID-19 infection shapes a dynamic immune microenvironment and affects the prognosis | 2024-12-06 | https://doi.org/10.1016/j.jinf.2024.106364 | Yinghui Peng | https://www.sciencedirect.com/science/article/pii/S0163445324002998 | In summary, in addition to pneumonia, COVID-19 may also affect the tumor immune microenvironment, which leads to tumor progression and a bad prognosis. The excessive immune microenvironment caused the up-regulation of the inhibitory effect, and the overexpression of immunosuppressive factors further strengthening the immune escape of the tumor, leading to tumor progression. | |||||||||||||||||||||
36 | SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm | 2024-12-06 | https://doi.org/10.1101/2024.12.05.626967 | Antoine Rebendenne | https://www.biorxiv.org/content/10.1101/2024.12.05.626967v1 | SARS-CoV-2-induced, cytoplasmic ATM pre-activation primes cells for an accelerated response to DNA damage, which might contribute to the severe outcomes of COVID-19 observed in cancer patients undergoing chemo- or radiotherapy. | |||||||||||||||||||||
37 | Post-acute sequelae of COVID-19 in cancer patients: Two cohorts in UK and Hong Kong | 2024-12-07 | https://doi.org/10.1002/cam4.70134 | Eric Yuk Fai Wan | https://onlinelibrary.wiley.com/doi/10.1002/cam4.70134 | Cancer patients with COVID-19 consistently showed significantly higher risk of major cardiovascular diseases (CVDs) [UKB: hazard ratio [HR] 1.8; HK: HR 1.4], CVD death [UKB: HR 4.3; HK: HR 1.7], and all-cause mortality [UKB: HR 4.7; HK: HR 1.6] in both cohorts despite the difference in dominant variants. Cancer patients at advanced ages or severely infected had higher all-cause mortality risk. | |||||||||||||||||||||
38 | SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma | 2024-12-10 | https://doi.org/10.3390/cells13242038 | Maryna Somova | https://www.mdpi.com/2073-4409/13/24/2038 | The presence of RCC cells amplified the immune-modulatory effects of the SARS-CoV-2 S protein on the renal epithelium, potentially exacerbating renal inflammation and fostering tumor-supportive conditions. These findings suggest that COVID-19 infections can impact renal function in the presence of kidney cancer. | |||||||||||||||||||||
39 | Pathways in the brain, heart, and lung influenced by SARS-CoV-2 NSP6 and SARS-CoV-2 regulated miRNAs: an in silico study hinting cancer incidence | 2024-12-30 | https://doi.org/10.1101/2024.02.11.578752 | Shrabonti Chatterjee | https://www.biorxiv.org/content/10.1101/2024.02.11.578752v2 | Our bioinformatics and systems study hints probable effect of COVID-19 infection in cancer incidence. Among the five common proteins revealed as potential therapeutic targets across the three tissues, Galectin3 (LGALS3) that was upregulated in the heart and brain after COVID-19 infection is reported to be influencing all the ten hallmarks of cancer positively and is found in multiple cancers. | |||||||||||||||||||||
40 | Alterations in Cellular Gene Expression Due to Co-Infection With Kaposi's Sarcoma-Associated Herpesvirus and SARS-CoV-2: Implications for Disease Severity | 2024-12-30 | https://doi.org/10.1002/jmv.70149 | Jungang Chen | https://onlinelibrary.wiley.com/doi/10.1002/jmv.70149 | These data provide a molecular basis for understanding whether patients with pre-existing oncogenic herpesvirus infections are at increased risk for more severe COVID-19 or for developing virus-associated cancers even after full recovery from COVID-19. | |||||||||||||||||||||
41 | P0304 SARS-COV-2 in Colorectal Cancer of IBD Patients | 2025-01-22 | https://doi.org/10.1093/ecco-jcc/jjae190.0478 | M M Boscá Watts | https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i757/7967367 | Biopsies: All frequent viruses were negative, whereas coronavirus was found in all cases, with a diffuse cytoplasmic and granular pattern. The incidence of CRC (colorectal cancer) in our patients in the past two years is relevant. The type of tumour and its locations also calls our attention, as well as the fact that all tumours have SARS-COV-2 protein abundance. |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 134 | |||||||||||||||||||||||||
3 | Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) | 2020-05-01 | https://doi.org/10.3389/fimmu.2020.00827 | Bo Diao | https://pubmed.ncbi.nlm.nih.gov/32425950/ | The number of total T cells, CD4+ and CD8+ T cells were dramatically reduced in COVID-19 patients, especially in patients requiring Intensive Care Unit (ICU) care. T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. | |||||||||||||||||||||
4 | Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia | 2020-07-06 | https://doi.org/10.1038/s41467-020-17292-4 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7338513/ | Sara De Biasi | https://pubmed.ncbi.nlm.nih.gov/32632085/ | Compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1+CD57+ exhausted T cells. | ||||||||||||||||||||
5 | Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 | 2020-10-01 | https://doi.org/10.1016/j.cell.2020.08.025 | Naoki Kaneko | https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2931067-9 | Germinal centers are lost in lymph nodes and spleens in acute COVID-19. Bcl-6+ GC B cells and Bcl-6+ T follicular helper cells are markedly diminished. These data suggest an underlying basis for the lower quality and lack of durability of humoral immune responses observed during natural infection with SARS-CoV-2 and have significant implications for expectations of herd immunity. | |||||||||||||||||||||
6 | Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection | 2021-01-04 | https://doi.org/10.1172/JCI140491 | PMC7773371 | Jacob K. Files | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773371/ | Our findings show increased frequencies of T cell activation markers (CD69, OX40, HLA-DR, and CD154) in hospitalized patients, with other T cell activation/exhaustion markers (PD-L1 and TIGIT) remaining elevated in hospitalized and nonhospitalized individuals. Interestingly, many of these changes were found to increase over time in nonhospitalized longitudinal samples, suggesting a prolonged period of immune dysregulation after SARS-CoV-2 infection. These data suggest a prolonged period of immune dysregulation after SARS-CoV-2 infection, highlighting the need for additional studies investigating immune dysregulation in convalescent individuals. | ||||||||||||||||||||
7 | Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review | 2021-03-12 | https://doi.org/10.3389/fimmu.2021.645013 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7994612/ | Kuo-Tung Tang | https://pubmed.ncbi.nlm.nih.gov/33777042/ | A variety of autoimmune/rheumatic manifestations were associated with COVID-19. The manifestations that have a consistent association with COVID-19 include autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. Our systematic review indicated the potential of the COVID-19 virus to trigger a myriad of autoimmune and rheumatic manifestation. | ||||||||||||||||||||
8 | Alterations in T and B cell function persist in convalescent COVID-19 patients | 2021-03-31 | https://doi.org/10.1016/j.medj.2021.03.013 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8011689/ | Halima A Shuwa | https://pubmed.ncbi.nlm.nih.gov/33821250/ | Our data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge. We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic program evident.. | ||||||||||||||||||||
9 | Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health | 2021-05-07 | https://doi.org/10.3389/fimmu.2021.676932 | Townsend Liam | https://www.frontiersin.org/articles/10.3389/fimmu.2021.676932/full | We demonstrate myeloid recovery but persistent T cell abnormalities in convalescent COVID-19 patients more than three months after initial infection. These changes are more marked with age and are independent of ongoing subjective ill-health, fatigue and reduced exercise tolerance. | |||||||||||||||||||||
10 | The impact of COVID-19 outbreak on the incidence of acute invasive fungal rhinosinusitis | 2021-05-14 | https://doi.org/10.1016/j.amjoto.2021.103080 | https://pubmed.ncbi.nlm.nih.gov/34022619/ | Wael F Ismaiel | https://pubmed.ncbi.nlm.nih.gov/34022619/ | The incidence of AIFRS (Acute invasive fungal rhinosinusitis) is markedly prominent in post-COVID-19 patients than in those of non-COVID-19, especially in immunocompromised, diabetic, renal, and liver dysfunction patients and patients with risk factors for rhinosinusitis. | ||||||||||||||||||||
11 | Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors | 2021-06-01 | https://doi.org/10.3390%2Fijms22116151 | Alessia Mongelli | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201243/ | The results show a consistent biological age increase in the post-COVID-19 population, determining a DeltaAge acceleration of 10.45 ± 7.29 years (+5.25 years above the range of normality) compared with 3.68 ± 8.17 years for the COVID-19-free population (p < 0.0001). A significant telomere shortening parallels this finding in the post-COVID-19 cohort compared with COVID-19-free subjects (p < 0.0001). Additionally, In light of these observations, we hypothesize that some epigenetic alterations are associated with the post-COVID-19 condition, particularly in younger patients (< 60 years). | |||||||||||||||||||||
12 | Profound dysregulation of T cell homeostasis and function in patients with severe COVID-19 | 2021-06-30 | https://doi.org/10.1111/all.14866 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8251365/ | Sarah Adamo | https://pubmed.ncbi.nlm.nih.gov/33884644/ | Severe COVID-19 is characterized by extensive T cell dysfunction and T cell apoptosis, which is associated with signs of homeostatic T cell proliferation and T cell recovery. | ||||||||||||||||||||
13 | Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19 | 2021-07-06 | https://doi.org/10.1093/jmcb/mjab014 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7989217/ | Jingyi Yang | https://pubmed.ncbi.nlm.nih.gov/33751111/ | Severe acute respiratory syndrome coronavirus 2 infection profoundly affects lymphocytes and potentially results in dysfunction even after clinical recovery. By taking into account the number of days after discharge, all the phenotypes associated with reduced function did not show a tendency toward recovery within 4‒11 weeks. | ||||||||||||||||||||
14 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection | 2021-07-21 | https://doi.org/10.1038/s41423-021-00728-2 | Pérez-Gómez, A | https://www.nature.com/articles/s41423-021-00728-2 | Dendritic cells (DCs) play a key role in the defense against viral infections. Previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. | |||||||||||||||||||||
15 | T cell responses to SARS-CoV-2 in people with and without neurologic symptoms of long COVID | 2021-08-09 | https://doi.org/10.1101%2F2021.08.08.21261763 | Lavanya Visvabharathy | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366804/ | Neuro-PASC patients exhibit distinct immunological signatures composed of elevated humoral and cellular responses toward SARS-CoV-2 Nucleocapsid protein at an average of 6 months post-infection compared to healthy COVID convalescents. | |||||||||||||||||||||
16 | New-onset IgG autoantibodies in hospitalized patients with COVID-19 | 2021-09-14 | https://doi.org/10.1038/s41467-021-25509-3 | Sarah Esther Chang | https://www.nature.com/articles/s41467-021-25509-3 | Autoantibodies are identified in approximately 50% of patients but in less than 15% of healthy controls. A subset of autoantibodies targeting traditional autoantigens or cytokines develop de novo following SARS-CoV-2 infection. | |||||||||||||||||||||
17 | SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism | 2021-09-22 | https://doi.org/10.1038/s41392-021-00749-3 | Jing, Y. | https://www.nature.com/articles/s41392-021-00749-3 | SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism. | |||||||||||||||||||||
18 | Impaired function and delayed regeneration of dendritic cells in COVID-19 | 2021-10-06 | https://doi.org/10.1371/journal.ppat.1009742 | Elena Winheim | https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009742 | Persisting reduction of all DC (dendritic cells) subpopulations was accompanied by an expansion of proliferating Lineage−HLADR+ cells lacking DC markers. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients. | |||||||||||||||||||||
19 | PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response | 2021-12-22 | https://doi.org/10.1172%2Fjci.insight.146701 | PMC8783674 | Cristian Loretelli | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783674/ | In these patients, T cells were exhausted, with increased PD-1+ T cells, as compared with healthy controls. Plasma levels of IL-1β, IL-1RA, and IL-8, among others, were also increased in patients who recovered from COVID-19. This altered immunophenotype was mirrored by a reduced ex vivo T cell response to both nonspecific and specific stimulation, revealing a dysfunctional status of T cells, including a poor response to SARS-CoV-2 antigens. | ||||||||||||||||||||
20 | Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection | 2022-01-13 | https://doi.org/10.1038/s41590-021-01113-x | Chansavath Phetsouphanh | https://www.nature.com/articles/s41590-021-01113-x | Patients with LC had highly activated innate immune cells, lacked naive T and B cells and showed elevated expression of type I IFN (IFN-β) and type III IFN (IFN-λ1) that remained persistently high at 8 months after infection. | |||||||||||||||||||||
21 | Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection | 2022-01-14 | https://doi.org/10.1186/s12916-021-02228-6 | Ryan, F.J. | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02228-6 | RNA sequencing revealed significant perturbations to gene expression in COVID-19 convalescents until at least 6 months post-infection. Deep immunophenotyping revealed significant differences in multiple innate (NK cells, LD neutrophils, CXCR3+ monocytes) and adaptive immune populations (T helper, T follicular helper, and regulatory T cells) in convalescent individuals compared to healthy controls, which were most strongly evident at 12 and 16 weeks post-infection. | |||||||||||||||||||||
22 | T cell apoptosis characterizes severe Covid-19 disease | 2022-01-22 | https://doi.org/10.1038/s41418-022-00936-x | André, S. | https://rdcu.be/cY1cH | Our results are compatible with a model in which T-cell apoptosis accounts for T lymphopenia in individuals with severe COVID-19. | |||||||||||||||||||||
23 | Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis | 2022-01-27 | https://doi.org/10.1016/j.jns.2022.120162 | Lavienraj Premraj | https://www.jns-journal.com/article/S0022-510X(22)00021-1/fulltext | In a meta-analysis of 18 studies encompassing 10,530 patients (hospitalised and non-hospitalised), overall prevalence for neurological symptoms three months after COVID-19 onset was: fatigue (37%), brain fog (32%), memory issues (28%), attention disorder (22%), myalgia (17%), anosmia (12%), dysgeusia (10%), and headache (15%). The prevalence of neuropsychiatric symptoms was sleep disturbances (31%), anxiety (23%), and depression (17%). | |||||||||||||||||||||
24 | SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts | 2022-02-04 | https://doi.org/10.3390/biomedicines10020382 | Abenaya Muralidharan | https://www.mdpi.com/2227-9059/10/2/382 | SARS-CoV-2-infected neutrophils had a direct effect on peripheral blood lymphocyte counts, with decreasing numbers of CD19+ B cells, CD8+ T cells, and CD4+ T cells. Together, this study highlights the independent role of neutrophils in contributing to the aberrant immune responses observed during SARS-CoV-2 infection that may be further dysregulated in the presence of other immune cells. | |||||||||||||||||||||
25 | ACE2-independent infection of T lymphocytes by SARS-CoV-2 | 2022-03-11 | https://doi.org/10.1038/s41392-022-00919-x | Shen, XR | https://www.nature.com/articles/s41392-022-00919-x | we showed that SARS-CoV-2 infected T lymphocytes, mainly CD4 + T cells, in an ACE2-independent manner. SARS-CoV-2 infection triggered pronounced T-cell death, which potentially contributed to lymphopenia in patients with COVID-19. T-cell infection may also pose profound influences on patients. Infected T lymphocytes not only lost the ability to control viral infection but may also carry viruses to other parts of the body through blood circulation. | |||||||||||||||||||||
26 | Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages | 2022-03-15 | https://doi.org/10.1038/s41385-021-00482-8 | Sina Bohnacker | https://www.nature.com/articles/s41385-021-00482-8 | Monocyte-derived macrophages (MDM) from SARS-CoV-2-infected individuals with mild disease show an inflammatory transcriptional and metabolic imprint that lasts for at least 5 months after SARS-CoV-2 infection. SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/ macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19. | |||||||||||||||||||||
27 | Comparison of Hematological and Biochemical Parameters of SARS-CoV-2-Positive and -Negative Neonates of COVID-19 Mothers in a COVID-19 Hospital, Odisha State | 2022-04-05 | 10.7759/cureus.23859 | Santosh K. Panda | https://www.cureus.com/articles/90918-comparison-of-hematological-and-biochemical-parameters-of-sars-cov-2-positive-and--negative-neonates-of-covid-19-mothers-in-a-covid-19-hospital-odisha-state | SARS-CoV-2-infected neonates (newborn infants) had lower hemoglobin, neutrophil to lymphocyte ratio, total white blood cell count, and absolute neutrophil count compared to noninfected babies (p<0.05). | |||||||||||||||||||||
28 | FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation | 2022-04-06 | https://doi.org/10.1038/s41586-022-04702-4 | Caroline Junqueira | https://www.nature.com/articles/s41586-022-04702-4 | These findings suggest that antibody-mediated SARS-CoV-2 uptake by monocytes and macrophages triggers inflammatory cell death that aborts the production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis. | |||||||||||||||||||||
29 | Accelerated biological aging in COVID-19 patients | 2022-04-19 | https://doi.org/10.1038/s41467-022-29801-8 | Xue Cao | https://www.nature.com/articles/s41467-022-29801-8?s=09 | Individuals with COVID-19 were estimated to have significant DNAm age acceleration for Hannum, PhenoAge, skinHorvath and GrimAge clocks and significant DNAm TL attrition acceleration compared with healthy individuals. The same phenomena were observed in the young (age < 50) and old (age ≥ 50) populations. Together, we found an accelerated epigenetic aging in patients with SARS-CoV-2 infection. | |||||||||||||||||||||
30 | Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases | 2022-05-01 | https://doi.org/10.1053%2Fj.gastro.2022.04.037 | Andreas Zollner | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057012/ | We report expression of SARS-CoV-2 RNA in the gut mucosa ∼7 months after mild acute COVID-19 in 32 of 46 patients with IBD. Postacute sequelae of COVID-19 were reported from the majority of patients with viral antigen persistence, but not from patients without viral antigen persistence. Our results indicate that SARS-CoV-2 antigen persistence in infected tissues serves as a basis for postacute COVID-19. | |||||||||||||||||||||
31 | T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19 | 2022-05-14 | https://doi.org/10.1111/all.15372 | Patrick Taeschler | https://onlinelibrary.wiley.com/doi/10.1111/all.15372 | T-cell numbers and function recover in most patients after COVID-19. However, we find evidence of persistent T-cell activation up to 12 months after infection and describe a subgroup of severe COVID-19 patients with persistently low CD8+ T-cell counts exhibiting a dysregulated immune response during acute infection. | |||||||||||||||||||||
32 | SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly | 2022-05-20 | https://doi.org/10.1101/2022.05.20.492764 | Anna Onnis | https://www.biorxiv.org/content/10.1101/2022.05.20.492764v1 | We report a new mechanism of immune evasion by SARS-CoV2 based on direct disabling CTLs (Cytotoxic T lymphocytes) to form immune synapses through Spike protein binding to ACE2. This mechanism could contribute to the failure of the immune system to control SARS-CoV-2 infection. | |||||||||||||||||||||
33 | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure | 2022-06-14 | https://doi.org/10.1126/science.abq1841 | CATHERINE J. REYNOLDS | https://www.science.org/doi/10.1126/science.abq1841 | Immune protection is boosted by B.1.1.529 (Omicron) infection in the triple-vaccinated, previously infection-naïve individuals, but this boosting is lost with prior Wuhan Hu-1 imprinting. This “hybrid immune damping” indicates substantial subversion of immune recognition. Omicron infection after previous Wuhan Hu-1 infection failed to boost neutralizing antibody and T cell responses against Omicron, revealing a profound imprinting effect and explaining why frequent reinfections occur. | |||||||||||||||||||||
34 | Persistent Autoimmune Activation and Proinflammatory State in Post-Coronavirus Disease 2019 Syndrome | 2022-06-15 | https://doi.org/10.1093/infdis/jiac017 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8903340/ | Yeny Acosta-Ampudia | https://pubmed.ncbi.nlm.nih.gov/35079804/ | The clinical manifestations of PCS (Post-COVID Syndrome) are associated with the persistence of a proinflammatory and effector phenotype induced by SARS-CoV-2 infection. This long-term persistent immune activation may contribute to the development of latent and overt autoimmunity. | ||||||||||||||||||||
35 | Distinguishing features of Long COVID identified through immune profiling | 2022-08-10 | https://doi.org/10.1101/2022.08.09.22278592 | Jon Klein | https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1 | Marked differences were noted in specific circulating myeloid and lymphocyte populations relative to matched control groups, as well as evidence of elevated humoral responses directed against SARS-CoV-2 among participants with Long COVID. Further, unexpected increases were observed in antibody responses directed against non-SARS-CoV-2 viral pathogens, particularly Epstein-Barr virus. Analysis of circulating immune mediators and various hormones also revealed pronounced differences, with levels of cortisol being uniformly lower among participants with Long COVID relative to matched control groups. | |||||||||||||||||||||
36 | Mucosal Immunity After Novel COVID-19 Infection – Virus-Induced Immunosuppression: Preliminary Study | 2022-09-02 | https://doi.org/10.1007/s12668-022-01020-x | Agafonova, E. | https://link.springer.com/article/10.1007/s12668-022-01020-x | Virus-induced, functional, and metabolic impairment of neutrophils of the mucosal immunity system develop in recovered COVID-19 patients. Virus-induced functional and metabolic disorders at the neutrophils level require lengthy rehabilitation and provide a scientific rationale for immunomodulatory therapy in recovered COVID-19 patients. | |||||||||||||||||||||
37 | Increasing Cases of SARS-CoV-2 Omicron Reinfection Reveals Ineffective Post-COVID-19 Immunity in Denmark and Conveys the Need for Continued Next-Generation Sequencing | 2022-09-14 | https://doi.org/10.1101/2022.09.13.22279912 | Scott Burkholz | https://www.medrxiv.org/content/10.1101/2022.09.13.22279912v1 | An analysis of the sub-lineages associated with an Omicron primary infection and Omicron reinfection reveals that the incidence of Omicron-Omicron reinfections is occurring over a shorter time interval than seen after a primary infection with a non-Omicron VOC. Our analysis suggests that a single infection from SARS-CoV-2 may not generate the protective immunity required to defend against reinfections from emerging Omicron lineages | |||||||||||||||||||||
38 | Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution | 2022-09-16 | https://doi.org/10.1101/2022.09.15.507787 | Yunlong Cao | https://www.biorxiv.org/content/10.1101/2022.09.15.507787v1 | Here we demonstrate that these convergent mutations can cause striking evasion of convalescent plasma, including those from BA.5 breakthrough infection, and existing antibody drugs, including Evusheld and Bebtelovimab. BA.2.75.2 is the most evasive strain tested, and only BQ.1.1 could compare. These results suggest herd immunity established by natural infection could hardly stop RBD evolution, and vaccine boosters using BA.5 may not provide sufficiently broad protection. | |||||||||||||||||||||
39 | Post-acute sequelae of covid-19 six to 12 months after infection: population based study | 2022-10-13 | https://doi.org/10.1136/bmj-2022-071050 | Raphael S Peter | https://www.bmj.com/content/379/bmj-2022-071050 | This study suggests a considerable burden of self-reported post-acute symptom clusters and possible sequelae, notably fatigue and neurocognitive impairment, six to 12 months after acute SARS-CoV-2 infection, even among young and middle aged adults after mild infection, with a substantial impact on general health and working capacity. | |||||||||||||||||||||
40 | Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis | 2022-10-19 | https://doi.org/10.1101/2022.10.18.512708 | Thomas Kehrer | https://www.biorxiv.org/content/10.1101/2022.10.18.512708v1 | SARS-CoV-2 ORF6 subverts bidirectional nucleo-cytoplasmic trafficking to inhibit host gene expression and contribute to viral pathogenesis. | |||||||||||||||||||||
41 | Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome | 2022-10-19 | https://doi.org/10.3389/fimmu.2022.949787 | Eirini Apostolou | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.949787/full | At 3-6 months after mild/asymptomatic SARS-CoV-2 infection, virus-specific antibodies in saliva were substantially induced signifying a strong reactivation of latent viruses (EBV, HHV6 and HERV-K) in both cohorts. In patients with ME/CFS, antibody responses were significantly stronger. Our results denote an altered and chronically aroused anti-viral profile against latent viruses in ME/CFS. SARS-CoV-2 infection even in its mild/asymptomatic form is a potent trigger for reactivation of latent herpesviruses (EBV, HHV6) and endogenous retroviruses (HERV-K). | |||||||||||||||||||||
42 | Multimodal neuroimaging in post-COVID syndrome and correlation with cognition | 2022-10-26 | https://doi.org/10.1093/brain/awac384 | María Díez-Cirarda | https://academic.oup.com/brain/article/146/5/2142/6775147?login=false | The present study shows persistent structural and functional brain abnormalities 11 months after the acute infection. Post-COVID syndrome patients presented with functional connectivity changes, characterized by hypoconnectivity between left and right parahippocampal areas, and between bilateral orbitofrontal and cerebellar areas compared to controls. These alterations were accompanied by reduced grey matter volume in cortical, limbic and cerebellar areas, and alterations in white matter axial and mean diffusivit | |||||||||||||||||||||
43 | Defective antifungal immunity in patients with COVID-19 | 2022-11-30 | https://doi.org/10.3389/fimmu.2022.1080822 | Charles Oliver Morton | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080822/full | Reduced fungicidal activity of neutrophils from COVID-19 patients indicates that immune dysfunction/imbalance are important risk factors for IFD. The COVID-19 pandemic has significantly increased the at-risk population for IFD. | |||||||||||||||||||||
44 | Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition | 2022-12-01 | https://doi.org/10.1038/s41590-022-01351-7 | Tye, E.X.C. | https://www.nature.com/articles/s41590-022-01351-7 | Of the 17 epitopes located in the spike protein, 10 were mutated in VOCs and CD4+ T cell clone recognition of 7 of them was impaired, including 3 of the 4 epitopes mutated in omicron. Our results indicated that broad targeting of epitopes by CD4+ T cells likely limits evasion by current VOCs. However, continued genomic surveillance is vital to identify new mutations able to evade CD4+ T cell immunity. | |||||||||||||||||||||
45 | Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals | 2022-12-02 | https://doi.org/10.3389/fimmu.2022.1034159 | Partha Chattopadhyay | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full | COVID-19 recovered individuals exhibited a hyper-activated inflammatory response with the loss of B cell maturation, suggesting an impeded post-infection stage | |||||||||||||||||||||
46 | Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19 | 2022-12-02 | https://doi.org/10.1002/jmv.28364 | Christoph Schultheiß | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28364 | These data confirm prior evidence of immune dysregulation and persistence of viral protein in PASC. At a median time of 8 months after infection, we found pronounced dysregulation in almost all tested soluble factors, including both pro-inflammatory and pro-fibrotic cytokines. These immunological perturbations were remarkably independent of ongoing PASC symptoms per se, but further correlation and regression analyses suggested PASC-specific patterns. | |||||||||||||||||||||
47 | COVID-19 and the increase in schizophrenia incidence in the future: A hypothesis and a serious warning | 2022-12-05 | https://doi.org/10.1002/hsr2.978 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9721364/ | Mohammad Pourfridoni | https://pubmed.ncbi.nlm.nih.gov/36479392/ | The results showed that multiple immune system changes brought on by COVID-19 have been identified as potential causes of schizophrenia. It is predicted that one of the long-term effects of COVID-19 is an increase in the risk of schizophrenia incidence based on the results of this study | ||||||||||||||||||||
48 | Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium | 2022-12-21 | https://doi.org/10.1126/scitranslmed.add0484 | JOHN B. FINLAY | https://www.science.org/doi/10.1126/scitranslmed.add0484 | These findings indicate that T cell–mediated inflammation persists in the olfactory epithelium long after SARS-CoV-2 has been eliminated from the tissue, suggesting a mechanism for long-term post–COVID-19 smell loss. | |||||||||||||||||||||
49 | Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 | 2022-12-26 | https://doi.org/10.1038/s41467-022-35638-y | Allison K. Maher | https://www.nature.com/articles/s41467-022-35638-y | Mild and moderate covid-19 can reprogram monocytes/affect gene-expression in covid-19 monocytes and indirectly disrupt metabolism this way. Functions that are related to promoting thrombosis are upregulated. Functions that are related to glycolysis and recognizing pathogens were downregulated. This monocyte dysfunction may contribute to covid-19 pathology. | |||||||||||||||||||||
50 | Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19 | 2023-01-04 | https://doi.org/10.3389/fimmu.2022.1082912 | Francis R. Hopkins | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082912/full#.Y99mfovKQFM.twitter | Alterations in the immune landscape remain more than 6 months after severe COVID-19, which could be indicative of ongoing healing and/or persistence of viral antigens. | |||||||||||||||||||||
51 | Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study | 2023-01-10 | https://doi.org/10.1016%2Fj.eclinm.2022.101783 | Renin Chang | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830133/ | COVID-19 is associated with a different degree of risk for various autoimmune diseases. After matching, the COVID-19 cohort exhibited significantly higher risks of rheumatoid arthritis (aHR:2.98), ankylosing spondylitis (Adjusted hazard ratio:3.21), systemic lupus erythematosus (aHR:2.99),systemic sclerosis (aHR:2.58), Sjögren's syndrome (aHR:2.62), mixed connective tissue disease (aHR:3.14), polymyalgia rheumatica (aHR:2.90), vasculitis (aHR:1.96), inflammatory bowel disease (aHR:1.78), celiac disease (aHR:2.68), type 1 diabetes mellitus (aHR:2.68) and mortality (aHR:1.20). | |||||||||||||||||||||
52 | COVID-19 INDUCES SENESCENCE AND EXHAUSTION OF T CELLS IN PATIENTS WITH MILD/MODERATE AND SEVERE DISEASE DURING A SEVEN-DAY INTERVAL | 2023-01-18 | https://doi.org/10.1101/2023.01.16.23284612 | Rodrigo Pedroso | https://www.medrxiv.org/content/10.1101/2023.01.16.23284612v1 | These results support the view that SARS CoV 2 infection can accelerate immunosenescence in both CD4 and CD8 T cell compartments in a short period of time. Our data, with patients from Portugal and Brazil, identified their distinctive inflammatory profile and provided evidence of increased frequencies of senescent and exhausted T cells within a seven day period in patients with mild to severe COVID 19 | |||||||||||||||||||||
53 | Incident autoimmune diseases in association with a SARS-CoV-2 infection: A matched cohort study | 2023-01-26 | https://doi.org/10.1101/2023.01.25.23285014 | Falko Tesch | https://www.medrxiv.org/content/10.1101/2023.01.25.23285014v1 | Comparing the incidence rates in the COVID-19 and matched control groups, we found a 42.63% higher likelihood of acquiring autoimmunity for patients who had suffered from COVID-19. (Sample IRR: Hashimoto thyroiditis, 1.42, Graves' disease 1.41, Rheumatoid arthritis 1.42, Diabetes Type 1 with Insulin 1.25, Multiple sclerosis 1.20, Celiac disease 1.55, Guillain–Barré syndrome 2.14, Ulcerative colitis 1.3) | |||||||||||||||||||||
54 | SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity | 2023-02-08 | https://doi.org/10.1016/j.jaci.2023.01.022 | Marco Rosichini MSc | https://www.sciencedirect.com/science/article/pii/S0091674923001471 | Our data demonstrate that the human thymus is a target of SARS-CoV-2 and thymic function is altered following infection.Patients with COVID-19 had reduced thymic function that was inversely associated with the severity of the disease. We also demonstrated that SARS-CoV-2 can target TECs (thymic epithelial cells) and downregulate critical genes and pathways associated with epithelial cell adhesion and survival. | |||||||||||||||||||||
55 | Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2 | 2023-02-10 | https://doi.org/10.1101/2023.02.09.527892 | Kailin Yin | https://www.biorxiv.org/content/10.1101/2023.02.09.527892v1 | Our findings demonstrate that individuals with LC exhibit systemic inflammation and immune dysregulation. Collectively, our data suggest that proper crosstalk between the humoral and cellular arms of adaptive immunity has broken down in LC, and that this, perhaps in the context of persistent virus, leads to the immune dysregulation, inflammation, and clinical symptoms associated with this debilitating condition. | |||||||||||||||||||||
56 | Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles | 2023-02-16 | https://doi.org/10.1101/2023.02.15.23285584 | Tom Aschman | https://www.medrxiv.org/content/10.1101/2023.02.15.23285584v1 | Compared to two independent historical control cohorts, patients with post-COVID exertion intolerance had fewer capillaries, thicker capillary basement membranes and increased numbers of CD169+ macrophages. SARS-CoV-2 RNA could not be detected in the muscle tissues, but transcriptomic analysis revealed distinct gene signatures compared to the two control cohorts, indicating immune dysregulations and altered metabolic pathways. We hypothesize that the initial viral infection may have caused immune-mediated structural changes of the microvasculature. | |||||||||||||||||||||
57 | Robust T cell responses to Pfizer/BioNTech vaccine compared to infection and evidence of attenuated peripheral CD8+ T cell responses due to COVID-19 | 2023-03-15 | https://doi.org/10.1016/j.immuni.2023.03.005 | Fei Gao | https://www.cell.com/immunity/fulltext/S1074-7613(23)00125-5 | Vaccination resulted in robust Spike-specific T cell responses for the dominant CD4+ (HLA-DRB1∗15:01/S191) and CD8+ (HLA-A∗02/S691) T cell epitopes. Peripheral T cell responses were elevated compared to COVID-19 patients. We also found that prior SARS-CoV-2 infection resulted in decreased CD8+ T cell activation and expansion, suggesting that prior infection can influence the T cell response to vaccination. (NOTE: Vaccinations were more effective than infections in generated T cell response, and people infected prior to the initial vaccination regimen had reduced TC activation from vaccinations.) | |||||||||||||||||||||
58 | Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID | 2023-03-15 | https://doi.org/10.1183/13993003.02226-2022 | http://www.ncbi.nlm.nih.gov/pubmed/36922030 | Nicholas A. Scott | https://erj.ersjournals.com/content/early/2023/02/23/13993003.02226-2022 | Long COVID patients with unresolved lung injury, indicated by sustained shortness of breath and abnormal chest radiology, were defined by high monocyte expression... Conversely, monocytes from long COVID patients with ongoing fatigue exhibited sustained reduction of the prostaglandin-generating enzyme COX-2... These monocyte changes were not present in RSV or flu convalescence. | ||||||||||||||||||||
59 | A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation | 2023-03-15 | https://doi.org/10.15252%2Fmsb.202211361 | Weiguang Mao | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167476/ | The differential methylation caused by asymptomatic or mildly symptomatic infections was indistinguishable. While differential gene expression largely returned to baseline levels after the virus became undetectable, some differentially methylated sites persisted for months of follow‐up, with a pattern resembling autoimmune or inflammatory disease. | |||||||||||||||||||||
60 | Autoantibody production is enhanced after mild SARS-CoV-2 infection despite vaccination in individuals with and without long COVID | 2023-04-12 | https://doi.org/10.1101/2023.04.07.23288243 | L Visvabharathy | https://www.medrxiv.org/content/10.1101/2023.04.07.23288243v1 | Mild SARS-CoV-2 infection can induce persistent humoral autoimmunity in both long COVID patients and healthy COVID convalescents, suggesting that a reappraisal of vaccination and mitigation strategies is warranted. | |||||||||||||||||||||
61 | Clinical and immunological features in children with multisystem inflammatory syndrome associated with SARS-CoV-2 | 2023-04-24 | https://doi.org/10.23750/abm.v94i2.13777 | Indira Jaxybayeva | https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/13777 | Conditions requiring ICU care in children with MIS-C are associated with a more profound immune dysregulation, as evidenced by our data. | |||||||||||||||||||||
62 | Association of SARS-CoV-2 infection and persistence with long COVID | 2023-05-10 | https://doi.org/10.1016/S2213-2600(23)00142-X | Chengliang Yang | https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00142-X/fulltext | The presented evidence suggests that the duration of SARS-CoV-2 infection in patients can persist considerably longer than suggested by PCR-negative tests on nasopharyngeal swabs or bronchoalveolar lavage fluids... Here we present a pathophysiological model of long COVID based on the persistence of SARS-CoV-2 virus that triggers a dysregulation of the immune system. | |||||||||||||||||||||
63 | Disrupted seasonality and association of COVID-19 with medically attended respiratory syncytial virus infections among young children in the US: January 2010–January 2023 | 2023-05-16 | https://doi.org/10.1101/2023.05.12.23289898 | Lindsey Wang | https://www.medrxiv.org/content/10.1101/2023.05.12.23289898v1 | The monthly incidence rate for first-time medically attended cases, most of which were severe RSV-associated diseases, reached a historical high rate of 2,182 cases per 1,0000,000 person-days in November 2022, corresponding to a related increase of 143% compared to expected peak rate (rate ratio: 2.43, 95% CI: 2.25–2.63). Among 228,940 children aged 0–5 years, the risk for first-time medically attended RSV during 10/2022–12/2022 was 6.40% for children with prior COVID-19 infection, higher than 4.30% for the matched children without COVID-19 (risk ratio or RR: 1.40, 95% CI: 1.27–1.55); and among 99,105 children aged 0–1 year, the overall risk was 7.90% for those with prior COVID-19 infection, higher than 5.64% for matched children without (RR: 1.40, 95% CI: 1.21–1.62). These data provide evidence that COVID-19 contributed to the 2022 surge of severe pediatric RSV cases. | |||||||||||||||||||||
64 | Disrupted seasonality and association of COVID-19 with medically attended respiratory syncytial virus infections among young children in the US: January 2010–January 2023 | 2023-05-16 | https://doi.org/10.1101/2023.05.12.232898988 | Lindsey Wang | https://www.medrxiv.org/content/10.1101/2023.05.12.23289898v1 | Among 228,940 children aged 0–5 years, the risk for first-time medically attended RSV during 10/2022–12/2022 was 6.40% for children with prior COVID-19 infection, higher than 4.30% for the matched children without COVID-19 (risk ratio or RR: 1.40, 95% CI: 1.27–1.55); and among 99,105 children aged 0–1 year, the overall risk was 7.90% for those with prior COVID-19 infection, higher than 5.64% for matched children without (RR: 1.40, 95% CI: 1.21–1.62). | |||||||||||||||||||||
65 | Persistent Exhausted T-Cell Immunity after Severe COVID-19: 6-Month Evaluation in a Prospective Observational Study | 2023-05-18 | https://doi.org/10.3390/jcm12103539 | Elena Vazquez-Alejo | https://www.mdpi.com/2077-0383/12/10/3539 | The immunological activation in the SARS-CoV-2 group during hospitalization is reversed at the follow-up time point. However, the marked exhaustion pattern remains over time. This dysregulation could constitute a risk factor for reinfection and the development of other pathologies. Additionally, high SARS-CoV-2-specific T-cells response levels appear to be associated with infection severity. | |||||||||||||||||||||
66 | Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19 | 2023-07-31 | https://doi.org/10.1101%2F2023.07.27.23293177 | PMC10418298 | Michael J. Peluso | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418298/ | We identified cellular SARS-CoV-2 RNA in rectosigmoid lamina propria tissue in all these participants, ranging from 158 to 676 days following initial COVID-19 illness, suggesting that tissue viral persistence could be associated with long-term immunological perturbations. | ||||||||||||||||||||
67 | The plasma metabolome of long COVID patients two years after infection | 2023-08-01 | https://doi.org/10.1038/s41598-023-39049-x | Yamilé López-Hernández | https://www.nature.com/articles/s41598-023-39049-x | Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, and chronic immune dysregulation are likely to be the main hallmarks of long COVID even two years after acute COVID-19 infection. Compared to controls, 27 metabolites remained dysregulated even after two years. | |||||||||||||||||||||
68 | Risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination: a population-based cohort study | 2023-08-16 | https://doi.org/10.1016/j.eclinm.2023.102154 | Kuan Peng | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00331-0/fulltext | Compared with non-COVID controls, patients with COVID-19 presented an increased risk of developing pernicious anaemia [adjusted Hazard Ratio (aHR): 1.72]; spondyloarthritis [aHR: 1.32]; rheumatoid arthritis [aHR: 1.29]; other autoimmune arthritis [aHR: 1.43]; psoriasis [aHR: 1.42]; pemphigoid [aHR: 2.39]; Graves' disease [aHR: 1.30]; anti-phospholipid antibody syndrome [aHR: 2.12]; immune mediated thrombocytopenia [aHR: 2.1]; multiple sclerosis [aHR: 2.66]; vasculitis [aHR: 1.46]. | |||||||||||||||||||||
69 | Epigenetic memory of coronavirus infection in innate immune cells and their progenitors | 2023-08-18 | https://doi.org/10.1016/j.cell.2023.07.019 | Jin-Gyu Cheong | https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1 | Alterations in innate immune phenotypes and epigenetic programs of HSPC (hematopoietic stem and progenitor cells) persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis. | |||||||||||||||||||||
70 | Incidence of immune-mediated inflammatory diseases following COVID-19: a matched cohort study in UK primary care | 2023-09-21 | https://doi.org/10.1186/s12916-023-03049-5 | Umer Syed | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03049-5 | SARS-CoV-2 was associated with an increased incidence of IMIDs (immune-mediated inflammatory diseases) including T1DM (type 1 diabetes mellitus), IBD (inflammatory bowel disease) and psoriasis. Patients in the exposed cohort had a 22% increased risk of developing an IMID, compared to the unexposed cohort (aHR 1.22, 95% CI 1.12 to 1.33). | |||||||||||||||||||||
71 | Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19 | 2023-10-06 | doi:10.1001/jamanetworkopen.2023.36120 | Sung Ha Lim | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2810259 | COVID-19 was associated with a substantial risk for autoimmune and autoinflammatory connective tissue disorders. The risks of alopecia areata (adjusted hazard ratio [aHR], 1.12; 95% CI, 1.05-1.19), alopecia totalis (aHR, 1.74; 95% CI, 1.39-2.17), antineutrophil cytoplasmic antibody–associated vasculitis (aHR, 2.76; 95% CI, 1.64-4.65), Crohn disease (aHR, 1.68; 95% CI, 1.31-2.15), and sarcoidosis (aHR, 1.59; 95% CI, 1.00-2.52) were higher in the COVID-19 group. | |||||||||||||||||||||
72 | Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity | 2023-10-09 | https://doi.org/10.3389/fimmu.2023.1254899 | Julia C. Berentschot | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1254899/full | Immune abnormalities that were found in the entire group of long COVID patients were low grade inflammation (increased inflammatory gene expression in monocytes, increased serum pro-inflammatory cytokines) and signs of T-lymphocyte senescence (increased exhausted CD8+ TEMRA-lymphocytes). Long COVID with fatigue is associated with many concurrent and persistent symptoms lasting up to one year after hospitalization. | |||||||||||||||||||||
73 | SARS-CoV-2 antibodies cross-react and enhance dengue infection | 2023-10-10 | https://doi.org/10.1101/2023.10.09.557914 | Kamini Jakhar | https://www.biorxiv.org/content/10.1101/2023.10.09.557914v1 | Anti-SARS-CoV-2 antibodies can cross-react with DENV-2 (Dengue virus) and can enhance its infection through ADE (Antibody-dependent enhancement). Our findings demonstrated that the SARS-CoV-2 antibodies can enhance the 328 DENV-2 infection. | |||||||||||||||||||||
74 | Association Between Guillain-Barré Syndrome and COVID-19 Infection and Vaccination | 2023-11-14 | https://doi.org/10.1212/WNL.0000000000207900 | Haya Bishara | https://www.neurology.org/doi/10.1212/WNL.0000000000207900 | Our study suggests that SARS-CoV-2 infection is associated with increased risk of GBS, whereas Pfizer-BioNTech COVID-19 vaccine is associated with decreased risk of GBS. Multivariable conditional logistic regression models showed that the odds ratio for GBS associated with SARS-CoV-2 infection and COVID-19 vaccine administration was 6.30 (95% CI 2.55–15.56) and 0.41 (95% CI 0.17–0.96), respectively. | |||||||||||||||||||||
75 | Immune system perturbations in patients with long COVID | 2024-01-04 | https://doi.org/10.1016/j.molmed.2023.12.008 | Lucie Rodriguez | https://www.sciencedirect.com/science/article/pii/S1471491423003027 | At the group level, LC subjects exhibited elevated antibody responses to SARS-CoV-2, but also to herpes viruses, pointing to a general suppression of viral control mechanisms in LC. | |||||||||||||||||||||
76 | Accelerated immune ageing is associated with COVID-19 disease severity | 2024-01-11 | https://doi.org/10.1186/s12979-023-00406-z | Janet M. Lord | https://immunityageing.biomedcentral.com/articles/10.1186/s12979-023-00406-z | Our analyses reveal a state of enhanced immune ageing in survivors of severe COVID-19 and suggest this could be related to SARS-Cov-2 infection. We found increased immunesenescence features in severe COVID-19 survivors compared to controls... the IMM-AGE score was significantly higher in severe COVID-19 survivors than in controls (p < 0.001). Few differences were seen for those with moderate disease and none for mild disease. | |||||||||||||||||||||
77 | Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome | 2024-01-17 | https://doi.org/10.3389/fimmu.2024.1341843 | Suguru Saito | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1341843/full | Our results demonstrate that LC patients exhibit persistent metabolomic abnormalities 12 months after the acute COVID-19 disease. Of note, such metabolomic alterations can be observed in the R (Recovered) group 12 months after the acute disease. Hence, the metabolomic recovery period for infected individuals with SARS-CoV-2 might be long-lasting. In particular, we found a significant reduction in sarcosine and serine concentrations in LC patients, which was inversely correlated with depression, anxiety, and cognitive dysfunction scores. | |||||||||||||||||||||
78 | Persistent complement dysregulation with signs of thromboinflammation in active Long Covid | 2024-01-19 | https://doi.org/10.1126/science.adg7942 | Carlo Cervia-Hasler | https://www.science.org/doi/10.1126/science.adg7942 | Long COVID exhibited changes to blood serum proteins indicating activation of the immune system’s complement cascade, altered coagulation, and tissue injury. Long Covid patients exhibited increased complement activation during acute disease, which also persisted at 6-month follow-up. Our data suggest that active Long Covid is accompanied by a blood protein signature marked by increased complement activation and thromboinflammation, including activated platelets and markers of red blood cell lysis. | |||||||||||||||||||||
79 | New-onset autoimmune disease after COVID-19 | 2024-02-08 | https://doi.org/10.3389/fimmu.2024.1337406 | Corrilynn O Hileman | https://pmc.ncbi.nlm.nih.gov/articles/PMC10883027/ | Cutaneous vasculitis (adjusted hazard ratio (aHR): 1.82; 95% CI 1.55–2.13), polyarteritis nodosa (aHR: 1.76; 95% CI 1.15–2.70), and hypersensitivity angiitis (aHR: 1.64; 95% CI 1.12–2.38) had the highest risk ratios. Overall, psoriasis (0.15%), rheumatoid arthritis (0.14%), and type 1 diabetes (0.13%) had the highest incidence during the study period, and of these, psoriasis and diabetes were more likely after COVID-19. | |||||||||||||||||||||
80 | Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19 | 2024-02-15 | https://doi.org/10.1101/2024.02.15.24302857 | August Jernbom Falk | https://www.medrxiv.org/content/10.1101/2024.02.15.24302857v1 | We have systematically investigated the temporal dynamics of the emerging self-directed humoral response in COVID-19 and showed that 60% of new-onset autoantibodies remained elevated for at least 12 months after infection. The prevalence and persistence of new-onset autoantibodies in COVID-19 implies that dysregulated humoral immunity is a marked feature of acute and post-acute COVID-19, as in many viral infections. Our study shows that newonset autoantibodies are prevalent and persistent in mild to severe COVID-19. Furthermore, some were found to be associated with neuropsychiatric symptoms post-COVID19 and could be detected in both plasma and CSF of patients with neuro-COVID. | |||||||||||||||||||||
81 | Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity | 2024-05-03 | https://doi.org/10.1038/s42003-024-05922-2 | Thai Hien Tu | https://www.nature.com/articles/s42003-024-05922-2 | Our findings underscore the potential significance of TCF1+ progenitor T-cells in accounting for the loss of immunity in severe COVID-19 and outline an array of markers that could be used to identify disease progression. Our results showed a preferential decline in TCF1+ progenitor CD4 and CD8+ T-cells with disease severity. This decline was seen in various TCF1+ subsets including naive, memory and effector-memory cells, and surprisingly, was accompanied by a loss in cell division as seen by a marked decline in Ki67 expression. | |||||||||||||||||||||
82 | Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection | 2024-07-03 | https://doi.org/10.1126/scitranslmed.adk3295 | MICHAEL J. PELUSO | https://www.science.org/doi/10.1126/scitranslmed.adk3295 | We identified intracellular SARS-CoV-2 single-stranded spike protein–encoding RNA in rectosigmoid lamina propria tissue in all five participants and double-stranded spike protein–encoding RNA in three participants up to 676 days after initial COVID-19, suggesting that tissue viral persistence could be associated with long-term immunologic perturbations. Tracer uptake in the postacute COVID-19 group, which included those with and without continuing symptoms, was higher compared with prepandemic controls in many regions, including the brain stem, spinal cord, bone marrow, nasopharyngeal and hilar lymphoid tissue, cardiopulmonary tissues, and gut wall. T cell activation in the spinal cord and gut wall was associated with the presence of LC symptoms. | |||||||||||||||||||||
83 | MENSA, a Media Enriched with Newly Synthesized Antibodies, to Identify SARS-CoV-2 Persistence and Latent Viral Reactivation in Long-COVID | 2024-07-07 | https://doi.org/10.1101/2024.07.05.24310017 | Natalie S. Haddad | https://www.medrxiv.org/content/10.1101/2024.07.05.24310017v1 | MENSA (Media Enriched with Newly Synthesized Antibodies) offers a unique antibody snapshot to reveal the underlying viral drivers in long-COVID thus demonstrating the persistence of SARS2 and reactivation of viral herpes in 60% of PASC patients. In PASC patients, MENSAs are also positive for Epstein-Barr Virus (EBV) in 37%, Human Cytomegalovirus (CMV) in 23%, and herpes simplex virus 2 (HSV2) in 15% compared to 17%, 4%, and 4% in CR controls respectively. | |||||||||||||||||||||
84 | Differential decline of SARS-CoV-2-specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID-19 | 2024-07-14 | https://doi.org/10.1111/all.16210 | Bernhard Kratzer | https://onlinelibrary.wiley.com/doi/10.1111/all.16210 | 10 w after COVID-19, patients' had significantly fewer circulating neutrophils compared to noninfected control subjects... Instead of an activation and expansion of CD3+CD4+ and CD3+CD8+ effector memory cells and transitional B cells and plasmablasts, we found a significant reduction of adaptive immune cells, including T cells (particularly CD3+CD45RA+CD62L+CD31+ RTE) and B cells (non-class-switched CD19+IgD+CD27+ memory B cells) 10 m after COVID-19. Along with the reductions of neutrophils, monocytes and NK cells, it thus seems that a single SARS-CoV-2 infection may cause a long-lasting impact on the cells of the innate and adaptive immune system. | |||||||||||||||||||||
85 | Differential decline of SARS-CoV-2-specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID-19 | 2024-07-14 | https://doi.org/10.1111/all.16210 | Bernhard Kratzer | https://onlinelibrary.wiley.com/doi/full/10.1111/all.16210 | COVID-19 causes long-term reduction of innate and adaptive immune cells which is associated with a Th2 serum cytokine profile. We found a significant reduction of adaptive immune cells, including T cells and B cells 10 m after COVID-19. Along with the reductions of neutrophils, monocytes and NK cells, it thus seems that a single SARS- CoV-2 infection may cause a long- lasting impact on the cells of the innate and adaptive immune system. | |||||||||||||||||||||
86 | Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation | 2024-07-15 | https://doi.org/10.1097/INF.0000000000004470 | Buonsenso, Danilo | https://journals.lww.com/pidj/fulltext/9900/circulating_activated_platelets_in_children_with.947.aspx | These data demonstrate that platelets in children with Long Covid circulate in an activated state... Our findings, along with those on multisystem inflammatory syndrome showing microvascular damage, suggest that SARS-CoV-2 infection can determine long-term endothelial inflammation in children similarly to adults. Noteworthy, the present data agree with the increased p-selectin and CD63 expression on circulating platelets of adults 1 year after COVID-19. | |||||||||||||||||||||
87 | SARS-CoV-2 infection predisposes patients to coinfection with Staphylococcus aureus | 2024-07-22 | https://doi.org/10.1128/mbio.01667-24 | Ashira Lubkin | https://journals.asm.org/doi/10.1128/mbio.01667-24 | We noted a trend toward overrepresentation of S. aureus bloodstream strains with low cytotoxicity in the SARS-CoV-2+ group. We observed that patients coinfected with SARS-CoV-2 and S. aureus were more likely to die during the acute phase of infection when the coinfecting S. aureus strain exhibited high or low cytotoxicity... These studies revealed that infection with SARS-CoV-2 renders mice susceptible to subsequent superinfection with low cytotoxicity S. aureus. Thus, SARS-CoV-2 infection sensitizes the host to coinfections. | |||||||||||||||||||||
88 | Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes | 2024-07-29 | https://doi.org/10.1016/j.bj.2023.100650 | Iñigo Ximeno-Rodríguez | https://www.sciencedirect.com/science/article/pii/S2319417023000872 | From the process of more than 8 million experimental data registered in GISAID, an immunological escape mechanism and a greater probability of developing Acquired Immune Deficiency Syndrome by SARS-CoV-2 are observed, according to the mutations in the N gene deriving towards a Variant of Concern with a higher rate of systemic commitment. | |||||||||||||||||||||
89 | From human herpes virus-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID | 2024-08-19 | https://doi.org/10.1002/jmv.29864 | Michael Maes | https://onlinelibrary.wiley.com/doi/10.1002/jmv.29864 | This study shows that increased autoimmunity against components of the tight junctions as well as increased IgA levels to LPS of Gram-negative bacteria play a role in Long COVID and in its physio-affective phenome. These microbes, through structural similarities and molecular mimicry, or other mechanisms, can trigger cross-reactivity and subsequent autoimmune responses against the body's self-epitopes or modified neo-epitopes. These processes also lead to the activation of the IRS, inflammation, oxidative stress, nitrosative stress, and increased autoimmune responses to oxidatively modified neo-epitopes. | |||||||||||||||||||||
90 | Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study | 2024-08-20 | https://doi.org/10.1186/s13148-024-01724-9 | Calzari Luciano | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-024-01724-9 | Horvath's epigenetic clock showed a slight but significant age acceleration in post-COVID-19 patients. We also observed a substantial increase in stochastic epigenetic mutations (SEMs) in the post-COVID-19 group, implying potential epigenetic drift. SEM analysis identified 790 affected genes, indicating dysregulation in pathways related to insulin resistance, VEGF signaling, apoptosis, hypoxia response, T-cell activation, and endothelin signaling. | |||||||||||||||||||||
91 | Alterations in plasma proteome during acute COVID-19 and recovery | 2024-08-25 | https://doi.org/10.1186/s10020-024-00898-5 | Maciej Suski | https://molmed.biomedcentral.com/articles/10.1186/s10020-024-00898-5 | In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In total, we identified 167 proteins that were differentially regulated between follow-up and hospitalization, which functionally aggregated into immune system activation, complement and coagulation cascades, interleukins signalling, platelet activation, and extracellular matrix organization. | |||||||||||||||||||||
92 | Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | 2024-08-26 | https://doi.org/10.4049/immunohorizons.2400033 | Lavanya Visvabharathy | https://journals.aai.org/immunohorizons/article/8/8/577/267113/Mild-Primary-or-Breakthrough-SARS-CoV-2-Infection | We found that mild SARS-CoV-2 primary and breakthrough infections can induce persistent humoral autoimmunity in both patients with neuro-PASC and healthy COVID convalescents. Mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection. | |||||||||||||||||||||
93 | Antibody responses to common viruses according to COVID-19 severity and postacute sequelae of COVID-19 | 2024-09-09 | https://doi.org/10.1002/jmv.29862 | Marianna Karachaliou | https://onlinelibrary.wiley.com/doi/10.1002/jmv.29862 | Severe COVID-19 cases presented elevated antibody responses to latent viruses assessed long time after the acute infection [median (IQR): 31 months (25–37)]. Responses against EBV (Epstein-Barr virus), VZV (varicella zoster virus), and a respiratory polyomavirus, WUPyV (WU polyomavirus), were higher in people with PASC and particularly among active persistent cases and PASC with neuropsychiatric symptoms, even among those with nonsevere previous acute COVID-19 infection. | |||||||||||||||||||||
94 | Viral, Immunologic, and Laboratory Parameters in Patients With and Without Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | 2024-09-09 | https://doi.org/10.3346/jkms.2024.39.e237 | Sang Hyun Ra | https://pubmed.ncbi.nlm.nih.gov/39252682/ | Levels of NP (nucleocapsid protein) antigen and of various cytokines involved in immune responses become significantly elevated over time after COVID-19 diagnosis in PASC patients compared to non-PASC patients. This suggests that PASC is associated with prolonged immune dysregulation resulting from heightened antigenic stimulation. | |||||||||||||||||||||
95 | Telomere length in subjects with and without SARS-CoV-2 infection: a systematic review and meta-analysis | 2024-09-09 | https://doi.org/10.1590/1806-9282.20240387 | Faustino Ramón Pérez-López | https://www.scielo.br/j/ramb/a/5rFPyPYBD3PD754xgz8T4Xx/?lang=en# | Patients with SARS-CoV-2 infection displayed significantly shorter telomere length than uninfected subjects. | |||||||||||||||||||||
96 | Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection | 2024-09-10 | https://doi.org/10.3389/fimmu.2024.1448780 | Julio A. Huapaya | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1448780/full | At ten months after symptom onset, changes in the plasma proteome persist in both vaccinated and unvaccinated individuals, which may be relevant to post-acute sequelae of SARS-CoV-2 and other viral infections associated with post-acute infection syndromes. In the post-infection phase at three and ten months, there was persistent protein underexpression of pathways essential for cellular function, signaling, and homeostasis. | |||||||||||||||||||||
97 | Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | 2024-09-19 | https://doi.org/10.1093/jleuko/qiae180 | Rodrigo Balsinha Pedroso | https://academic.oup.com/jleukbio/advance-article-abstract/doi/10.1093/jleuko/qiae180/7762057?login=false | Our cross-sectional data show that COVID-19, but not other respiratory infections, rapidly increased cellular senescence and exhaustion in CD4 and CD8 T cells during early infection. In addition, longitudinal analyses with patients from Brazil and Portugal provided evidence of increased frequencies of senescent and exhausted T cells over a 7-d period in patients with mild/moderate and severe COVID-19. Altogether, the study suggests that accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection. | |||||||||||||||||||||
98 | Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children | 2024-09-19 | https://doi.org/10.1038/s41467-024-52246-0 | Harsita Patel | https://www.nature.com/articles/s41467-024-52246-0 | We show that neutrophil activation and apoptosis are prominent in multi-system inflammatory syndrome, and that this is partially shared with bacterial infection. We show that memory T cells from patients with multi-system inflammatory syndrome and bacterial infection are exhausted. | |||||||||||||||||||||
99 | Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients | 2024-09-24 | https://doi.org/10.1084/jem.20240637 | Adrian Gervais | https://rupress.org/jem/article/221/10/e20240637/276989/Autoantibodies-neutralizing-type-I-IFNs-underlie | We show here that ∼10% of patients hospitalized for severe TBE (Tick-borne encephalitis) carry auto-Abs neutralizing IFN-α2, -β, and/or -ω at the onset of disease, contrasting with only ∼1% of patients with moderate and mild TBE. Our findings also indicate that the neutralization of a single type I IFN can be sufficient to impair anti-TBEV immunity, consistent with previous findings in patients with COVID-19, influenza, and WNV encephalitis | |||||||||||||||||||||
100 | Single-Cell Analysis Reveals T Cell Dysfunction Driven by Macrophages and Differential Expression of Transposable Elements in Severe COVID-19 Patients | 2024-09-27 | https://doi.org/10.1016/j.heliyon.2024.e38688 | Airu Zhu | https://www.sciencedirect.com/science/article/pii/S2405844024147196 | Severe SARS-CoV-2 infection causes immune dysregulation by inducing M2 polarization and subsequent T cell exhaustion. Drastic T cell hyperactivation accompanying elevated T cell exhaustion was observed, predominantly in pleural effusion. | |||||||||||||||||||||
101 | SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus | 2024-09-30 | https://doi.org/10.1136/lupus-2023-001104 | Yeon Su Lee | https://lupus.bmj.com/content/11/2/e001104 | COVID-19 accelerated the development and progression of lupus by inducing autoantibody production, fibrosis and thrombosis. We evaluated the progression of lung fibrosis, a condition common to both patients with SLE and COVID-19 patients, in a COVID-19-infected lupus mouse model. This model exhibited more severe lung fibrosis compared with non-infected lupus mice. | |||||||||||||||||||||
102 | Cytokine Profile in Children Following SARS-CoV-2 Infection: Preliminary Findings | 2024-10-01 | https://doi.org/10.1097/inf.0000000000004558 | Buonsenso, Danilo | https://journals.lww.com/pidj/fulltext/9900/cytokine_profile_in_children_following_sars_cov_2.1036.aspx | Our preliminary findings suggest that children with previous SARS-CoV-2 infection, and particularly those with Long COVID, exhibit altered cytokine expression patterns involved in T cell homeostasis and coagulation, in line with adult studies. We provide preliminary evidence that, also in children, Long coronavirus disease (COVID) may be characterized by a proinflammatory signature. When adjusted for sex, children with long COVID had statistically significant differences in the levels of Flt3L, CD5, uPA, CCL23, CD40 and TGFα. | |||||||||||||||||||||
103 | Increased prevalence of inflammatory arthritis, systemic lupus erythematosus and systemic sclerosis, during 2020–2023 versus 2016–2019 in a Nation-Wide Cohort Study | 2024-10-08 | https://doi.org/10.1007/s00296-024-05733-y | Vasiliki-Kalliopi Bournia | Prevalence of RA (Rheumatoid Arthritis), PsA (Psoriatic Arthritis), AxSpA (Axial Spondyloarthritis), SLE(Systemic Lupus Erythematosus) and SSc (Systemic Sclerosis) increased significantly during 2020–2023 compared to 2016–2019. Overall, there was 47% increase in prevalence for AxSpA (0.100% in 2016–19 vs 0.147% in 2020–23), 36.5% for PsA (0.148% vs 0.202%), 20.6% for RA (0.467% vs 0.563%), 19% for SLE (0.137% vs 0.163%) and 13% for SSc (0.023% vs 0.026%). | ||||||||||||||||||||||
104 | Single-cell analysis reveals T cell dysfunction driven by macrophages and differential expression of transposable elements in severe COVID-19 patients | 2024-10-15 | https://doi.org/10.1016/j.heliyon.2024.e38688 | Airu Zhu | https://www.cell.com/heliyon/fulltext/S2405-8440(24)14719-6 | Our results suggest that severe SARS-CoV-2 infection causes immune dysregulation by inducing M2 polarization and subsequent T cell exhaustion. Specifically, strong mechanistic evidence of M2 macrophage-driven T cell exhaustion was elucidated. | |||||||||||||||||||||
105 | Trends of Common Laboratory Biomarkers after SARS-CoV-2 Infection | 2024-10-16 | https://doi.org/10.1016/j.jinf.2024.106318 | Tomer David Meirman | https://www.journalofinfection.com/article/S0163-4453(24)00252-4/fulltext | The most notable longer-lasting effects involved the immune system. One group of such findings included a 7-8 month decrease in WBC counts, mainly driven by decreased counts of neutrophils, monocytes, and basophils. Potassium levels were decreased for 3-5 months. | |||||||||||||||||||||
106 | SARS-CoV-2 Infection and the Neuroendocrine System | 2024-10-21 | https://doi.org/10.1159/000542164 | Shruti Sasikumar | https://karger.com/nen/article-abstract/doi/10.1159/000542164/915090/SARS-CoV-2-Infection-and-the-Neuroendocrine-System?redirectedFrom=PDF | There is potential for SARS-CoV-2 to induce autoimmune responses, exacerbate existing endocrine conditions and trigger new-onset disorders. The viral invasion disrupts normal hormonal pathways, leading to a range of endocrine disorders, including hormonal imbalances, immune dysregulation, and metabolic disturbances. | |||||||||||||||||||||
107 | T Regulatory Cell Subsets Do Not Restore for One Year After Acute COVID-19 | 2024-11-01 | https://doi.org/10.3390/ijms252111759 | Arthur Aquino | https://www.mdpi.com/1422-0067/25/21/11759 | One year after recovery, the decreased subpopulations of regulatory T cells (Tresgs) had not yet reached the levels observed in healthy donors. Finally, we observed the re-establishment of CD39 expression in all Treg subsets; however, there was no change in CD73 expression among Tregs. | |||||||||||||||||||||
108 | Utilizing blood single-cell transcriptomics to integrate intrinsic and systemic immune aging | 2024-11-03 | https://doi.org/10.1101/2024.10.30.621198 | Alan Tomusiak | https://www.biorxiv.org/content/10.1101/2024.10.30.621198v1 | We applied these tools to find acute COVID is associated with a shift in CD8+ cytotoxic cell proportions, while cell type proportions are stable in patients with HIV on long-term ART treatment (HIV+ART). Both COVID and HIV+ART were associated with an increase in naive CD8 T cell transcriptomic age. | |||||||||||||||||||||
109 | Beyond acute infection: mechanisms underlying post-acute sequelae of COVID-19 (PASC) | 2024-11-03 | https://doi.org/10.5694/mja2.52456 | Anurag Adhikari | https://onlinelibrary.wiley.com/doi/10.5694/mja2.52456 | Immune dysregulation is a key aspect of post-acute sequelae of coronavirus disease 2019 (PASC), also known as long COVID, with sustained activation of immune cells, T cell exhaustion, skewed B cell profiles, and disrupted immune communication thereby resulting in autoimmune-related complications. | |||||||||||||||||||||
110 | Long-Term Risk of Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19 | 2024-11-06 | doi:10.1001/jamadermatol.2024.4233 | Yeon-Woo Heo | https://jamanetwork.com/journals/jamadermatology/fullarticle/2825849 | This cohort study with an extended follow-up period revealed an increased long-term risk of autoimmune and autoinflammatory connective tissue disorders, including alopecia areata, alopecia totalis, vitiligo, Behçet disease, Crohn disease, ulcerative colitis, RA, SLE, Sjögren syndrome, ankylosing spondylitis, and bullous pemphigoid after COVID-19. Notably, COVID-19 severity was associated with a high risk of autoimmune diseases. Our study found a lower risk of autoimmune diseases during the Omicron period than during the Delta period. | |||||||||||||||||||||
111 | Dynamic Changes in Lymphocyte Populations and Their Relationship with Disease Severity and Outcome in COVID-19 | 2024-11-06 | https://doi.org/10.3390/ijms252211921 | Ákos Vince Andrejkovits | https://www.mdpi.com/1422-0067/25/22/11921 | We found significant differences in CD3+ lymphocytes between severity groups (p < 0.0001), with significantly decreased CD3+CD4+ and CD3+CD8+ in patients with severe disease (p < 0.0001 and p = 0.048, respectively). Lower CD3+/CD19+ and CD3+/NK ratios among patients with severe disease (p = 0.019 and p = 0.010, respectively) were found. | |||||||||||||||||||||
112 | COVID-19 infection is associated with an elevated risk for autoimmune blistering diseases while COVID-19 vaccination decreases the risk: A large-scale population-based cohort study of 112 million individuals | 2024-11-07 | https://doi.org/10.1016/j.jaad.2024.10.063 | Philip Curman | https://www.sciencedirect.com/science/article/pii/S0190962224031116 | COVID-19 infection significantly increases the risk of AIBD (autoimmune blistering diseases) while vaccination appears to reduce this risk. COVID-19 infection was associated with an increased risk of AIBD (HR 1.508, 95% CI 1.260-1.805), with the risk being more pronounced for pemphigus (HR 2.432, 1.618-3.657) compared to bullous pemphigoid (HR 1.376, 1.019-1.857). Comparisons between COVID-19 infection and vaccination revealed a more than threefold increased risk of AIBD in the infection cohort (HR 3.130, 2.411-4.063), particularly for pemphigus (HR 5.508, 2.973-10.205). | |||||||||||||||||||||
113 | Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms | 2024-11-09 | https://doi.org/10.1016/j.jare.2024.11.011 | Abbas F. Almulla | https://www.sciencedirect.com/science/article/pii/S2090123224005307 | The current study provides the first evidence indicating that autoimmune responses directed at neuronal proteins play a key role in Long COVID disease. Brain reactive autoantibodies directed at MBP, MOG, tubulin, CP2, and synapsin are elevated in patients with Long COVID disease indicating a neuro-autoimmune pathophysiology of this condition. | |||||||||||||||||||||
114 | Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 | 2024-11-16 | https://doi.org/10.1101/2024.11.14.622799 | Cole Maguire | https://www.biorxiv.org/content/10.1101/2024.11.14.622799v1 | Our findings highlight a remarkable prevalence and potential impact of chronic viral reactivation on host responses and clinical outcomes during acute COVID-19 and long term PASC sequelae. We reveal significant reactivation of Herpesviridae, Enteroviridae, and Anelloviridae families during acute stage of COVID-19 (0-40 days post-hospitalization), each exhibiting distinct temporal dynamics. | |||||||||||||||||||||
115 | Gut microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients | 2024-11-19 | https://doi.org/10.1101/2024.11.18.24317428 | Paula Scalzo | https://www.medrxiv.org/content/10.1101/2024.11.18.24317428v1 | Our study provides data in support of the hypothesis that immune responses and the gut-brain axis may be playing a role in regulating somatic and neuropsychiatric symptoms during acute COVID-19. Elevated interleukin-6 levels were observed in the most severe cases, indicating systemic inflammation. These findings suggest a link between mental health status, systemic inflammation, and gut dysbiosis in COVID-19 patients | |||||||||||||||||||||
116 | Exploring the landscape of symptom-specific inflammatory cytokines in post-COVID syndrome patients | 2024-11-22 | https://doi.org/10.1186/s12879-024-10222-5 | Chafik Tilikete | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-10222-5 | Our results further support the presence of endothelial dysfunction in PCS and show an elevation of pro-inflammatory cytokines with a downmodulation of the IL-10- anti-inflammatory response. Notably, our results elucidate immuno-clinical phenotypes, associating specific cytokines (IL-6, IL-27, and IL-8) with symptoms such as fatigue and dyspnea thus revealing varied pathophysiological mechanisms associated with different PCS symptoms. | |||||||||||||||||||||
117 | Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity | 2024-11-27 | https://doi.org/10.1038/s41390-024-03731-1 | Fanni Kovács | https://www.nature.com/articles/s41390-024-03731-1 | Neutrophil dysfunction in children with LCS may be part of the disease pathogenesis or a predisposing factor. LCS children experienced significantly more symptoms, impairing their QoL-F (quality of life and functioning) compared to CG+ (convalescent children). Neutrophilic granulocyte dysfunction was found in LCS children, with decreased superoxide-producing activity and phagocytosis compared to CG+. | |||||||||||||||||||||
118 | Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients | 2024-11-29 | https://doi.org/10.1016/j.bbi.2024.11.032 | Shima Shahbaz | https://www.sciencedirect.com/science/article/pii/S0889159124007219?via%3Dihub | We found that LC patients had a distinct transcriptional profile compared to controls. Key findings include the upregulation of genes involved in immune dysregulation and neuronal development, such as Fezf2, BRINP2, HOXC12, MEIS2, ZFHX3, and RELN. These genes are linked to neuroinflammatory responses, cognitive impairments, and hematopoietic disturbances, suggesting ongoing neurological and immune disturbances in LC patients. | |||||||||||||||||||||
119 | Long-term dysregulation of plasma peptidome in mild and multiple COVID-19 recovered patients revealed by a novel efficient peptidomics workflow | 2024-12-07 | https://doi.org/10.1007/s00216-024-05684-0 | Zhijing Song | https://link.springer.com/article/10.1007/s00216-024-05684-0 | The findings indicate persistent abnormalities in initial COVID-19 infections’ plasma peptide profiles, gradually diminishing over time. Secondary infections prolong recovery. Disrupted functions include lipid metabolism, coagulation and complement cascades, and infection-related pathways. Lipid metabolism may normalize within 3 months, while coagulation and immune abnormalities can last 3–6 months. | |||||||||||||||||||||
120 | Depressive disorder; clinical correlates and tumor necrosis factor alpha among post COVID-19 patients | 2024-12-12 | https://doi.org/10.1186/s43045-024-00487-6 | Aya Mohamed Khaled Sakr | https://link.springer.com/article/10.1186/s43045-024-00487-6 | The rate of post-COVID depression was 27.8%; predominately, mild MDD (major depressive disorder ) (47.6%), followed by moderate MDD (38.1%) then, severe MDD (14.3%). Using regression analysis; TNF-α (Serum tumor necrosis factor alfa) was the only predictive factor to post-COVID-19 depression (OR = 1.030, p < 0.001). | |||||||||||||||||||||
121 | Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection | 2024-12-12 | 10.3389/fimmu.2024.1488745 | Juliane Lokau | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1488745/abstract | In conclusion, our study shows long-lasting alterations of the IL-6 (interleukin-6) system after COVID-19 disease. We find that sIL-6R levels are not only increased in acute severely ill patients, but also in convalescents after a mild COVID-19 infection. | |||||||||||||||||||||
122 | Long COVID is associated with lower percentages of mature, cytotoxic NK cell phenotypes | 2024-12-17 | https://doi.org/10.1172/JCI188182 | Tasha Tsao | https://www.jci.org/articles/view/188182 | We observed that the proportion of NK (natural killer) cells with a mature and cytotoxic phenotype was significantly lower in people with LC compared to those who fully recovered. NK cells, a critical component of the viral innate immune response, can exhibit dysfunctional phenotypes during acute COVID-19, and these alterations may hinder clearance of SARS-CoV-2 infected cells. | |||||||||||||||||||||
123 | Increased prevalence of inflammatory arthritis, systemic lupus erythematosus and systemic sclerosis, during 2020–2023 versus 2016–2019 in a Nation-Wide Cohort Study | 2024-10-08 | https://doi.org/10.1007/s00296-024-05733-y | Vasiliki-Kalliopi Bournia | Prevalence of RA (Rheumatoid Arthritis), PsA (Psoriatic Arthritis), AxSpA (Axial Spondyloarthritis), SLE(Systemic Lupus Erythematosus) and SSc (Systemic Sclerosis) increased significantly during 2020–2023 compared to 2016–2019. Overall, there was 47% increase in prevalence for AxSpA (0.100% in 2016–19 vs 0.147% in 2020–23), 36.5% for PsA (0.148% vs 0.202%), 20.6% for RA (0.467% vs 0.563%), 19% for SLE (0.137% vs 0.163%) and 13% for SSc (0.023% vs 0.026%). | ||||||||||||||||||||||
124 | Long-term immune changes after COVID-19 and the effect of BCG vaccination and latent infections on disease severity | 2024-12-30 | https://doi.org/10.1101/2024.12.16.628601 | Kamila Bendíčková | https://www.biorxiv.org/content/10.1101/2024.12.16.628601v1 | Post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). These findings highlight the long–term alterations of immune cells in post–COVID–19 patients emphasizing the substantial impact of COVID–19 on immune function. | |||||||||||||||||||||
125 | Identification of an immunological signature of long COVID syndrome | 2025-01-07 | https://doi.org/10.3389/fimmu.2024.1502937 | Gisella Guerrera | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1502937/full | The findings highlight a unique immunological signature associated with LC syndrome, characterized by persistent adaptive immune dysregulation. LC patients displayed persistent immune alterations, including reduced T cell subsets (CD4, CD8, Tregs) and switched memory B cells, similar to COVID-19 patients. Through BGLM, a unique adaptive immune signature for LC was identified, featuring memory CD8 and gd T cells with low proliferative capacity and diminished expression of activation and homing receptors. | |||||||||||||||||||||
126 | Immune damage in Long Covid | 2024-01-18 | https://doi.org/10.1126/science.adn1077 | Wolfram Ruf | https://www.science.org/doi/10.1126/science.adn1077 | Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic immune cell activation and inflammation, widespread multiorgan dysfunction, and thrombosis. Not everyone fully recovers from COVID-19, leading to Long Covid, the treatment of which is a major unmet clinical need. | |||||||||||||||||||||
127 | Altered immune surveillance of B and T cells in patients with persistent residual lung abnormalities 12 months after severe COVID-19 | 2025-01-18 | https://doi.org/10.1186/s12931-025-03102-2 | Julio Flores-Gonzalez | https://link.springer.com/article/10.1186/s12931-025-03102-2 | Patients with residual lung abnormalities 12 months post-critical COVID-19 exhibit impaired B-cell function, increased unswitched B-cells, and higher frequencies of CD4 + TEMRA T-cells following in vitro activation. These immune imbalances may contribute to ongoing lung dysfunction | |||||||||||||||||||||
128 | Post-COVID-19 sequelae are associated with sustained SARS-CoV-2-specific CD4+ immune responses | 2025-01-27 | https://doi.org/10.1016/j.intimp.2025.114103 | Chiara Venegoni | https://www.sciencedirect.com/science/article/abs/pii/S156757692500092X | PASC patients showed an increase of SARS-CoV-2 specific CD4+ T cell response one year after the primary infection. SARS-CoV-2 specific CD4+ central memory T cells producing pro-inflammatory cytokines were increased in PASC patients. PASC patients with reduced pulmonary function and residual symptoms exhibit an increase of SARS-CoV-2 specific CD4+ T cell response. | |||||||||||||||||||||
129 | T-cell immunobiology and cytokine storm of COVID-19 | 2025-01-31 | https://doi.org/10.1016/bs.pmbts.2024.10.003 | Ahmed Eltayeb | https://www.sciencedirect.com/science/article/abs/pii/S1877117324001972 | people’s immune reactions to SARS-CoV-2 vary a lot, and an unbalanced inflammatory cytokine/chemokine response causes patients to have worse outcomes. While severe COVID-19 patients who survived the disease had considerable lymphopenia and increased neutrophils, especially in the elderly, their T cell numbers gradually recovered. Exhausted T lymphocytes and elevated levels of pro-inflammatory cytokines, including IL6, IL10, IL2, and IL17, are observed in peripheral blood and the lungs. | |||||||||||||||||||||
130 | Prevalence of anti-nuclear antibodies in COVID-19 patients: a remarkable 2.5-fold rise compared to healthy controls | 2025-02-01 | https://doi.org/10.1007/s11845-025-03886-8 | Faruk Dişli | One in every two to three individuals with COVID-19 exhibited ANA positivity, indicating that the SARS-CoV-2 virus poses a significant risk regarding autoimmunity. The SARS-CoV-2 virus significantly increases the formation of antinuclear antibodies. Given that a large portion of the population has been exposed to this virus and its variants, an increase in the prevalence of autoimmunity within the community may be anticipated. | ||||||||||||||||||||||
131 | Convalescent COVID-19 monocytes exhibit altered steady-state gene expression and reduced TLR2, TLR4 and RIG-I induced cytokine expression | 2025-02-07 | https://doi.org/10.1016/j.humimm.2025.111249 | Sarah Unterberger | These data suggest that following SARS-CoV-2 infection, monocytes exhibit altered steady-state gene expression and reduced responsiveness to innate immune receptor activation. A clinical consequence of a sustained decrease in the response of these pattern recognition receptors could also be an increased susceptibility to other bacterial and viral infections. | ||||||||||||||||||||||
132 | Causal associations of COVID-19 with health and disease outcomes: a systematic review and meta-analysis | 2025-02-10 | https://doi.org/10.1101/2025.02.07.25321697 | Lidong Gao | https://www.medrxiv.org/content/10.1101/2025.02.07.25321697v1 | This study demonstrates that COVID-19 infection has direct causal effects on human health or certain diseases at the genetic level, which may manifest as increased or decreased susceptibility to disease and changes in disease severity. Subgroup analyses identified an increased risk of neuropsychiatric disorders, including optic nerve disorders, epilepsy, schizophrenia, generalized anxiety disorder, stroke, myocardial infarction with COVID-19. There is also a notable association between COVID-19 and the immune system, particularly neuromyelitis optica spectrum disorders and myasthenia gravis. | |||||||||||||||||||||
133 | Convalescent COVID-19 monocytes exhibit altered steady-state gene expression and reduced TLR2, TLR4 and RIG-I induced cytokine expression | 2025-02-07 | https://doi.org/10.1016/j.humimm.2025.111249 | Sarah Unterberger | https://www.sciencedirect.com/science/article/pii/S0198885925000205 | Exposure to SARS-CoV-2 leads to a sustained alteration of host response gene expression post infection. Furthermore, the data reveal tolerance of TLR2, TLR4 and RIG-I activation lasting 3–6 months after SARS-CoV-2 infection in people recovering from both mild and severe COVID-19. A clinical consequence of a sustained decrease in the response of these pattern recognition receptors could also be an increased susceptibility to other bacterial and viral infections. | |||||||||||||||||||||
134 | Immunological and clinical markers of post-acute sequelae of COVID-19: Insights from mild and severe cases six months post-infection | 2025-02-21 | https://doi.org/10.1101/2025.02.18.638851 | William Mouton | https://www.biorxiv.org/content/10.1101/2025.02.18.638851v1 | This study assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two patient cohorts who experienced mild (n=270) or severe (n=188) COVID-19, 6 to 9 months post-initial infection, and in which 40% and 57.4% of patients, respectively, developed PASC. Patients with PASC displayed altered CD4+ and CD8+ memory T-cell subsets, with higher cytokine-secreting cells and increased terminally differentiated CD45RA+ effector memory T cells (TEMRA). | |||||||||||||||||||||
135 | Impact of COVID-19 infection on Kawasaki disease and immune status in children | 2025-02-21 | https://doi.org/10.1038/s41598-025-91042-8 | Lichao Gao | https://www.nature.com/articles/s41598-025-91042-8 | The risk of IVIG (intravenous immunoglobulin) resistance in children with KD onset 1–7 weeks after COVID-19 infection increased significantly, which may be related to the long-term impact of COVID-19 on immunity. Our study revealed that the risk of IVIG resistance in KD that occurred 1–7 weeks after COVID-19 infection increased, which may be related to changes in immune levels after COVID-19 infection. | |||||||||||||||||||||
136 | SARS-CoV-2 nucleocapsid uniquely disrupts chromatin over pathophysiologically relevant gene promoters | 2025-02-24 | https://doi.org/10.1101/2025.02.22.639619 | Jane M Benoit | https://www.biorxiv.org/content/10.1101/2025.02.22.639619v1 | Nucleocapsids from seven human coronaviruses alter nucleosome distribution and susceptibility to enzymatic digestion over specific gene promoters in a human lung cell line. Nucleocapsids from SARS-CoV and SARS-CoV-2 have the most prominent effects which are seen over genes involved in immune responses, metabolism, hormone signaling, and other pathways that are known to be dysregulated in severe COVID-19 and post-acute sequelae of COVID-19. |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 413 | |||||||||||||||||||||||||
3 | Nervous system involvement after infection with COVID-19 and other coronaviruses | 2020-03-30 | https://doi.org/10.1016/j.bbi.2020.03.031 | PMC7146689 | Yeshun Wu | https://pmc.ncbi.nlm.nih.gov/articles/PMC7146689/ | CoV infections can affect the nervous system, and it is currently believed that CoV in concert with host immune mechanisms may turn these infections into persistent infections that may lead to neurological diseases. | ||||||||||||||||||||
4 | Multiple Neuroinvasive Pathways in COVID-19 | 2020-09-29 | https://doi.org/10.1007/s12035-020-02152-5 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7523266/ | Dmitri Bougakov | https://pubmed.ncbi.nlm.nih.gov/32990925/ | There is a growing concern that in a number of patients, long-term or perhaps even permanent cognitive impairment will persist well after the recovery from acute illness. Furthermore, COVID-19 survivors may be at increased risk for developing neurodegenerative diseases years or decades later. Since COVID-19 is a new disease, it will take months or even years to characterize the exact nature, scope, and temporal extent of its long-term neurocognitive sequelae | ||||||||||||||||||||
5 | Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis | 2020-11-05 | https://doi.org/10.1016/j.ejrad.2020.109393 | Yangsean Choi | https://www.sciencedirect.com/science/article/pii/S0720048X20305830 | Considerable incidences of abnormal neuroimaging findings have been reported in patients with COVID-19. Acute to subacute cerebral infarction was the most prevalent neuroimaging finding. The pooled incidences of cerebral microhemorrhages, acute spontaneous ICH, acute/subacute infarcts, and encephalitis/encephalopathy were 6.9 % (95 % confidence interval [CI], 4.9 %–8.9 %), 5.4 % (95 % CI, 3.1 %–7.6 %), 24.0 % (95 % CI, 16.1 %–31.8 %), and 3.3 % (95 % CI, 1.9 %–4.7 %), respectively. | |||||||||||||||||||||
6 | Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients | 2021-02-02 | https://doi.org/10.1007/s13365-021-00954-4 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7852463/ | Joanna Hellmuth | https://pubmed.ncbi.nlm.nih.gov/33528824/ | An observational cohort study of individuals recovering from COVID-19 (14 or more days following symptom onset) identified that among the first 100 individuals enrolled, 14 were non-hospitalized patients reporting persistent cognitive issues. These 14 participants had a median age of 39 years (interquartile range: 35-56), and cognitive symptoms were present for at least a median of 98 days (interquartile range: 71-120 following acute COVID-19 symptoms); no participants with follow-up evaluation reported symptom resolution. | ||||||||||||||||||||
7 | Neuropsychiatric and Cognitive Sequelae of COVID-19 | 2021-03-01 | https://doi.org/10.3389/fpsyg.2021.577529 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7960660/ | Sanjay Kumar | https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2021.577529/full | Emerging evidence suggests that COVID-19 patients develop neurological symptoms such as headache, altered consciousness, and paraesthesia. Brain tissue oedema and partial neurodegeneration have also been observed in an autopsy. In addition, there are reports that the virus has the potential to cause nervous system damage. Together, these findings point to a possible role of the virus in the development of acute psychiatric symptoms and long-term neuropsychiatric sequelae of COVID-19. | ||||||||||||||||||||
8 | Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study | 2021-03-07 | https://doi.org/10.1007/s00259-021-05294-3 | Martina Sollini | https://link.springer.com/article/10.1007/s00259-021-05294-3 | [18F]FDG PET/CT acknowledged the multi-organ nature of long COVID, supporting the hypothesis of underlying systemic inflammation. Whole-body images showed increased [18F]FDG uptake in several “target” and “non-target” tissues. We found a typical pattern of brain hypometabolism associated with persistent complaints at the PET time, suggesting a different temporal sequence for brain and whole-body inflammatory changes. | |||||||||||||||||||||
9 | Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 “long haulers” | 2021-03-23 | https://doi.org/10.1002/acn3.51350 | Edith L. Graham | https://onlinelibrary.wiley.com/doi/10.1002/acn3.51350 | Non-hospitalized Covid-19 “long haulers” experience prominent and persistent “brain fog” and fatigue that affect their cognition and quality of life. SARS-CoV-2+ patients performed worse in attention and working memory cognitive tasks compared to a demographic-matched US population (T-score 41.5 [37, 48.25] and 43 [37.5, 48.75], respectively; both p < 0.01). | |||||||||||||||||||||
10 | Cognitive impairments four months after COVID-19 hospital discharge | 2021-04-03 | https://doi.org/10.1016/j.euroneuro.2021.03.019 | KW Miskowiak | https://www.sciencedirect.com/science/article/pii/S0924977X21001747?via%3Dihub | These findings provide new evidence for frequent cognitive sequelae of COVID-19 and indicate an association with the severity of the lung affection and potentially restricted cerebral oxygen delivery. The percentage of patients with clinically significant cognitive impairment ranged from 59% to 65% depending on the applied cut-off for clinical relevance of cognitive impairment, with verbal learning and executive functions being most affected. | |||||||||||||||||||||
11 | 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records | 2021-04-06 | https://doi.org/10.1016/S2215-0366(21)00084-5 | Maxime Taquet | https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(21)00084-5/fulltext | Our study provides evidence for substantial neurological and psychiatric morbidity in the 6 months after COVID-19 infection. Risks were greatest in, but not limited to, patients who had severe COVID-19. Among 236 379 patients diagnosed with COVID-19, the estimated incidence of a neurological or psychiatric diagnosis in the following 6 months was 33·62% (95% CI 33·17–34·07), with 12·84% (12·36–13·33) receiving their first such diagnosis. | |||||||||||||||||||||
12 | Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: Effect of inflammatory biomarkers at three-month follow-up | 2021-04-15 | https://doi.org/10.1016/j.bbi.2021.02.021 | Mazza Mario Gennaro | https://www.sciencedirect.com/science/article/pii/S0889159121000866?via%3Dihub | Three months after discharge from the hospital, 35.8% still self-rated symptoms in the clinical range in at least one psychopathological dimension. We observed persistent depressive symptomatology, while PTSD, anxiety, and insomnia decreased during follow-up. Regardless of clinical physical severity, 78% of the sample showed poor performances in at least one cognitive domain, with executive functions and psychomotor coordination being impaired in 50% and 57% of the sample. | |||||||||||||||||||||
13 | SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques | 2021-05-05 | https://doi.org/10.1101/2021.02.23.432474 | Ingrid H.C.H.M. Philippens | https://www.biorxiv.org/content/10.1101/2021.02.23.432474v2 | We observed Lewy bodies in brains of all rhesus macaques... Lewy bodies are considered a hallmark for the development of Parkinson’s disease, or Lewy body dementia. More confirmation is required, but the observations in the translational macaque models for COVID-19 (12-14, 40, 41) can be regarded as a serious warning as they may be predictive for COVID-19-related dementia cases in humans in the future, even after an asymptomatic infection or mild disease process. | |||||||||||||||||||||
14 | Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19 | 2021-05-07 | https://doi.org/10.1093/brain/awab009 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8083602/ | Jonas A Hosp | https://pubmed.ncbi.nlm.nih.gov/33822001/ | Neocortical dysfunction accompanied by cognitive decline was detected in a relevant fraction of patients with subacute COVID-19 initially requiring inpatient treatment. | ||||||||||||||||||||
15 | A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications | 2021-05-11 | https://doi.org/10.1016/j.jns.2021.117486 | Jennifer A. Frontera | https://www.jns-journal.com/article/S0022-510X(21)00180-5/fulltext | Overall, 346/382 (91%) patients had at least one abnormal outcome: 56% had limited ADLs, 50% impaired cognition, 47% could not return to work and 62% scored worse than average on ≥1 Neuro-QoL scale (worse anxiety 46%, sleep 38%, fatigue 36%, and depression 25%). In multivariable analysis, patients with neurological complications had worse 6-month mRS (median 4 vs. 3 among controls, adjusted OR 1.98, 95%CI 1.23–3.48, P = 0.02), worse ADLs (aOR 0.38, 95%CI 0.29–0.74, P = 0.01) and were less likely to return to work than controls (41% versus 64%, P = 0.04). | |||||||||||||||||||||
16 | Long-term neuropsychiatric outcomes in COVID-19 survivors: A 1-year longitudinal study | 2021-09-26 | https://doi.org/10.1111/joim.13389 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8662064/ | Raúl Méndez | https://onlinelibrary.wiley.com/doi/10.1111/joim.13389 | In summary, declined cognitive function, psychiatric morbidity and low QoL are prevalent in moderate to severe COVID-19 survivors 1 year after hospital discharge. We found 46.8% of patients with cognitive impairment and 45% with psychiatric morbidity at 1 year. | ||||||||||||||||||||
17 | Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells | 2021-10-08 | https://doi.org/10.3390%2Fv13102021 | PMC8538996 | Eun Seon Kim | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538996/ | This study shows that SARS-CoV-2 itself has toxic effects on the brain ECs including defective molecular delivery and metabolic function, suggesting a potential pathological mechanism to induce neurological signs in the brain. | ||||||||||||||||||||
18 | Long COVID syndrome-associated brain fog | 2021-10-21 | https://doi.org/10.1002/jmv.27404 | Ali A. Asadi-Pooya | https://onlinelibrary.wiley.com/doi/10.1002/jmv.27404 | In this large population-based study, we report that chronic post-COVID “brain fog” has significant associations with sex (female), respiratory symptoms at the onset, and the severity of the illness (ICU admission). 1680 (62.3%) people reported long COVID syndrome (LCS). LCS-associated brain fog was reported by 194 (7.2%) patients. | |||||||||||||||||||||
19 | Assessment of Cognitive Function in Patients After COVID-19 Infection | 2021-10-22 | doi:10.1001/jamanetworkopen.2021.30645 | Jacqueline H. Becker | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785388 | Hospitalized patients were more likely to have impairments in attention (odds ratio [OR]: 2.8; 95% CI: 1.3-5.9), executive functioning (OR: 1.8; 95% CI: 1.0-3.4), category fluency (OR: 3.0; 95% CI: 1.7-5.2), memory encoding (OR: 2.3; 95% CI: 1.3-4.1), and memory recall (OR: 2.2; 95% CI: 1.3-3.8) than those in the outpatient group. Patients treated in the ED were more likely to have impaired category fluency (OR: 1.8; 95% CI: 1.1-3.1) and memory encoding (OR: 1.7; 95% CI: 1.0-3.0) than those treated in the outpatient setting. | |||||||||||||||||||||
20 | Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study | 2021-10-27 | https://doi.org/10.1136/bmjopen-2021-055164 | Lovisa Hellgren | https://bmjopen.bmj.com/content/11/10/e055164 | In this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease. Twenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. | |||||||||||||||||||||
21 | COVID-19 Activated Parkinson’s Disease Through Oxidative Stress and The NLRP3 Pathway | 2022-01-01 | http://dx.doi.org/10.13140/RG.2.2.29924.04484/14 | Miura Traficante | https://www.researchgate.net/publication/365613369_COVID-19_Activated_Parkinson%27s_Disease_Through_Oxidative_Stress_and_The_NLRP3_Pathway | The current research found that COVID-19 directly leads to dopaminergic neuronal cell death through multiple mechanisms, suggesting that COVID-19 may activate PD (Parkinon's Disease) in individuals infected with COVID-19. If COVID-19 infection leads to dopaminergic cell death, causing PD symptomatology, then it can be inferred that COVID-19 may play a role in other DA (Dopamine) related disorders such as AD/HD and Schizophrenia. | |||||||||||||||||||||
22 | Long COVID-19: Objectifying most self-reported neurological symptoms | 2022-01-20 | https://doi.org/10.1002/acn3.51496 | Julia Bungenberg | https://onlinelibrary.wiley.com/doi/10.1002/acn3.51496 | Regardless of initial COVID-19 severity, an individuals' mental and physical health can be severely impaired in the long-term limitedly objectified by clinical standard diagnostic with abnormalities primarily found in hospitalized patients. Hospitalized patients performed worse in global cognition, logical reasoning, and processes of verbal memory. In both groups, fatigue severity was associated with reduced performance in attention and psychomotor speed tasks (rs = −0.40, p < 0.05) and reduced quality of life (EQ5D, rs = 0.57, p < 0.001) and with more persisting symptoms (median 3 vs. 6, p < 0.01). | |||||||||||||||||||||
23 | Multisystem screening reveals SARS-CoV-2 in neurons of the myenteric plexus and in megakaryocytes | 2022-02-02 | https://doi.org/10.1002/path.5878 | Sandra Gray-Rodriguez | https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.5878 | One striking finding was the widespread presence of SARS-CoV-2 NP in neurons of the myenteric plexus, a site of high ACE2 expression, the entry receptor for SARS-CoV-2, and one of the earliest affected cells in Parkinson's disease. In the bone marrow, we observed viral SARS-CoV-2 NP within megakaryocytes, key cells in platelet production and thrombus formation. | |||||||||||||||||||||
24 | Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study | 2022-02-05 | https://doi.org/10.1016/j.genhosppsych.2022.01.002 | Rodolfo Furlan Damiano | https://www.sciencedirect.com/science/article/pii/S0163834322000020?via%3Dihub | Diagnoses of ‘depression’, ‘generalized anxiety disorder’ and ‘post-traumatic stress disorder’ were established respectively in 8%, 15.5% and 13.6% of the sample. As a key finding, there was no significant association between clinical severity in the acute-phase of SARS-CoV-2 infection and the neuropsychiatric impairment 6 to 9 months thereafter. | |||||||||||||||||||||
25 | Neuropsychological deficits in patients with cognitive complaints after COVID-19 | 2022-02-08 | https://doi.org/10.1002/brb3.2508 | Carmen García-Sánchez | https://onlinelibrary.wiley.com/doi/10.1002/brb3.2508 | Results revealed pervasive impact on attention abilities, both as the singularly affected domain (19% of single-domain impairment) as well as coupled with decreased performance in executive functions, learning, and long-term memory. These findings stress the importance of comprehensive evaluation and intervention to address cognitive sequelae in post-COVID patients of varying disease courses, not just those who were hospitalized or experienced severe symptoms. | |||||||||||||||||||||
26 | Describing cognitive function and psychosocial outcomes of COVID-19 survivors: A cross-sectional analysis | 2022-03-01 | DOI: 10.1097/JXX.0000000000000647 | Henneghan, Ashley M. | https://journals.lww.com/jaanp/abstract/2022/03000/describing_cognitive_function_and_psychosocial.9.aspx | Cognitive dysfunction and psychological symptoms may be present in the weeks or months after COVID-19 diagnosis, even in those with mild to moderate illness severity. Forty percent of participants demonstrated scores that were 1 SD or more below the population norm on one or more of the cognitive tests. A subset had greater anxiety (21.15%), depressive symptoms (23.07%), and sleep disturbance (19.23%) than population norms. | |||||||||||||||||||||
27 | Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study | 2022-03-06 | https://doi.org/10.1007/s00415-022-11047-5 | Giordano Cecchetti | https://link.springer.com/article/10.1007/s00415-022-11047-5 | COVID-19 patients showed interrelated cognitive, EEG, and MRI abnormalities 2 months after hospital discharge. Cognitive and EEG findings improved at 10 months. Dysgeusia and hyposmia during acute COVID-19 were related with increased vulnerability in memory functions over time. | |||||||||||||||||||||
28 | Neurological manifestations of long-COVID syndrome: a narrative review | 2022-02-17 | https://doi.org/10.1177/20406223221076890 | Maria-Ioanna Stefanou | https://journals.sagepub.com/doi/10.1177/20406223221076890 | Manifestations of ‘long-COVID’ may affect any part of the human nervous system, while the most frequent neurological symptoms among ‘long-COVID’ patients encompass fatigue; ‘brain fog’; headache; cognitive impairment; sleep, mood, smell, or taste disorders; myalgias; sensorimotor deficits; and dysautonomia. Neurological ‘long-COVID’ sequelae, with clinically objectifiable correlates of CNS or PNS involvement, seem to affect at least one-third of patients with antecedent SARS-CoV-2 infection. | |||||||||||||||||||||
29 | The Impact of Long COVID-19 on Mental Health: Observational 6-Month Follow-Up Study | 2022-02-24 | https://doi.org/10.2196/33704 | https://www.ncbi.nlm.nih.gov/pmc/articles/8914795 | Sarah Houben-Wilke | https://mental.jmir.org/2022/2/e33704 | A substantial percentage of patients with confirmed COVID-19 and persistent complaints reported symptoms of PTSD, anxiety, or depression 3 and 6 months after the onset of COVID-19–related symptoms. At the 3-month follow-up, 37.2% (89/239) of the patients had symptoms of PTSD, 35.6% (85/239) had symptoms of anxiety, and 46.9% (112/239) had symptoms of depression, which remained high at the 6-month follow-up (64/239, 26.8%, P=.001; 83/239, 34.7%, P=.90; 97/239, 40.6%, P=.08, respectively; versus the 3-month follow-up). | ||||||||||||||||||||
30 | SARS-CoV-2 is associated with changes in brain structure in UK Biobank | 2022-03-07 | https://doi.org/10.1038/s41586-022-04569-5 | Gwenaëlle Douaud | https://www.nature.com/articles/s41586-022-04569-5 | We identified significant longitudinal effects when comparing the two groups, including (1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; (2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and (3) a greater reduction in global brain size in the SARS-CoV-2 cases. The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points. Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised. | |||||||||||||||||||||
31 | One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China | 2022-03-08 | doi:10.1001/jamaneurol.2022.0461 | Yu-Hui Liu, MD, PhD | https://jamanetwork.com/journals/jamaneurology/article-abstract/2789919 | Severe COVID-19 was associated with a higher risk of early-onset cognitive decline (odds ratio [OR], 4.87; 95% CI, 3.30-7.20), late-onset cognitive decline (OR, 7.58; 95% CI, 3.58-16.03), and progressive cognitive decline (OR, 19.00; 95% CI, 9.14-39.51), while nonsevere COVID-19 was associated with a higher risk of early-onset cognitive decline (OR, 1.71; 95% CI, 1.30-2.27) when adjusting for age, sex, education level, body mass index, and comorbidities. | |||||||||||||||||||||
32 | COVCOG 2: Cognitive and Memory Deficits in Long COVID: A Second Publication From the COVID and Cognition Study | 2022-03-17 | https://doi.org/10.3389/fnagi.2022.804937 | Panyuan Guo | https://www.frontiersin.org/articles/10.3389/fnagi.2022.804937/full | We found a consistent pattern of memory deficits in those that had experienced the COVID-19 infection, with deficits increasing with the severity of self-reported ongoing symptoms. Fatigue/Mixed symptoms during the initial illness and ongoing neurological symptoms were predictive of cognitive performance. | |||||||||||||||||||||
33 | Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience | 2022-03-23 | https://doi.org/10.1007/s00259-022-05753-5 | Verger, A. | https://link.springer.com/article/10.1007/s00259-022-05753-5 | On the 143 brain 18F-FDG PET scans performed during this 3-month period, 53% of the scans were visually interpreted as normal, 21% as mildly to moderately or incompletely affected, and 26% as severely affected according to the COVID hypometabolic pattern. On average, PET scans were performed at 10.9 months from symptom onset (± 4.8). | |||||||||||||||||||||
34 | Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study | 2022-04-09 | https://doi.org/10.1093/cid/ciab611 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8394862/ | Jessica Seeßle | https://pubmed.ncbi.nlm.nih.gov/34223884/ | (Investigating patients with Long-COVID symptoms five months after acute infection), At month 12, only 22.9% of patients were completely free of symptoms and the most frequent symptoms were reduced exercise capacity (56.3%), fatigue (53.1%), dyspnea (37.5%), and problems with concentration (39.6%), finding words (32.3%), and sleeping (26.0%). Females showed significantly more neurocognitive symptoms than males. Neurocognitive long-COVID symptoms can persist ≥1 year after COVID-19 symptom onset and reduce life quality significantly. | ||||||||||||||||||||
35 | Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints | 2022-04-11 | https://doi.org/10.3233/JAD-215506 | Daniela Andriuta | https://journals.sagepub.com/doi/full/10.3233/JAD-215506 | Post-acute COVID-19 patients with cognitive complaints had NCD (Neurocognitive disorders), with prominent action slowing, significantly associated with the acute phase oxygen requirement and a right-sided WMH (White matter hyperintensities) structure pattern. Repeated ANOVA (analysis of variance) showed a group effect (p = 0.0001) due to overall lower performance for patients and a domain effect (p = 0.0001) due to a lower (p = 0.007) action speed score. | |||||||||||||||||||||
36 | Brain Imaging Changes in Patients Recovered From COVID-19: A Narrative Review | 2022-04-21 | https://doi.org/10.3389/fnins.2022.855868 | Yan Huang | https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.855868/full | We found that the microscopic changes in the brain of mildest patients could be relieved after 6 months, while ICU patients were prone to long-term sequelae. In addition to focusing on the physical changes in the brain of post-COVID-19 patients, we found that patients with long-term neurological symptoms are prone to psychological disorders. | |||||||||||||||||||||
37 | Post-COVID-19 fatigue: the contribution of cognitive and neuropsychiatric symptoms | 2022-04-30 | https://doi.org/10.1007/s00415-022-11141-8 | Marco Calabria | https://link.springer.com/article/10.1007/s00415-022-11141-8 | Results showed that reports of clinical significant fatigue were pervasive in our sample (82.3% of participants), with physical fatigue rated highest on average relative to the subscale maximum. Elevated levels of apathy, anxiety, and executive dysfunction in neuropsychiatric measures along with executive and attentional difficulties on cognitive tests were found to be consistently important predictors among different types of fatigue. | |||||||||||||||||||||
38 | Studying the Effect of Long COVID-19 Infection on Sleep Quality Using Wearable Health Devices: Observational Study | 05/07/2022 | https://doi.org/10.2196/38000 | https://www.ncbi.nlm.nih.gov/pmc/articles/9258734 | Mario Mekhael | https://www.jmir.org/2022/7/e38000 | Regardless of the demographic background and symptom levels, patients with a history of COVID-19 infection demonstrated altered sleep architecture when compared to matched controls. When comparing different sleep phases, patients with long COVID-19 had decreased light sleep (244, SD 67 vs 258, SD 67; P=.003) and decreased deep sleep time (123, SD 66 vs 128, SD 58; P=.02). | ||||||||||||||||||||
39 | Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection | 2022-05-29 | https://doi.org/10.1177/15500594221103834 | Pablo Andrei Appelt | https://journals.sagepub.com/doi/10.1177/15500594221103834 | There was a reduction in brain activity at rest in the Fz-F4 areas and during high cognitive demands in the F3-F7 areas. A reduction in signal complexity in F3-F7 at rest was found in the COVID-19 group at 6-12 months after acute infection. Furthermore, individuals with COVID-19 experience long-term changes in cognitive function. | |||||||||||||||||||||
40 | Comprehensive clinical assessment identifies specific neurocognitive deficits in working-age patients with long-COVID | 2022-06-10 | https://doi.org/10.1371/journal.pone.0267392 | David A. Holdsworth | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267392 | Despite low rates of residual cardiopulmonary pathology, in this cohort, with low rates of premorbid illness, there is a high burden of symptoms and failure to regain pre-COVID performance 6-months after acute illness. Cognitive assessment identified a specific deficit of the same magnitude as intoxication at the UK drink driving limit or the deterioration expected with 10 years ageing, which appears to contribute significantly to the symptomatology of long-COVID. | |||||||||||||||||||||
41 | Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings | 2022-06-14 | https://doi.org/10.1038/s41380-022-01632-5 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9196149/ | Jonas Jardim de Paula | https://pubmed.ncbi.nlm.nih.gov/35701598/ | In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. | ||||||||||||||||||||
42 | Morphological, cellular, and molecular basis of brain infection in COVID-19 patients | 2022-06-15 | https://doi.org/10.1073/pnas.2200960119 | Fernanda Crunfli | https://www.pnas.org/doi/full/10.1073/pnas.2200960119 | We also show that astrocytes are susceptible to SARS-CoV-2 infection through a noncanonical mechanism that involves spike–NRP1 interaction and respond to the infection by remodeling energy metabolism, which in turn, alters the levels of metabolites used to fuel neurons and support neurotransmitter synthesis. The altered secretory phenotype of infected astrocytes then impairs neuronal viability. These features could explain the damage and structural changes observed in the brains of COVID-19 patients. | |||||||||||||||||||||
43 | Neuropsychological manifestations of long COVID in hospitalized and non-hospitalized Brazilian Patients | 2022-06-17 | DOI: 10.3233/NRE-228020 | Braga, L.W. | https://content.iospress.com/articles/neurorehabilitation/nre228020 | Neuropsychological results suggest executive function problems and high incidence of anxiety/depression, irrespective of acute-phase severity. The BNIS (Barrow Neurological Institute Screen for Higher Cerebral Functions) score was significantly below reference values in all subscales, especially affect and memory. Verbal Fluency and Clock Drawing subtest results were also lower. | |||||||||||||||||||||
44 | Frequency of Neurological Diseases After COVID-19, Influenza A/B and Bacterial Pneumonia | 2022-06-23 | https://doi.org/10.3389/fneur.2022.904796 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9259944/ | Pardis Zarifkar | https://pubmed.ncbi.nlm.nih.gov/35812108/ | Compared to COVID-negative outpatients, COVID-19 positive outpatients had an increased RR of Alzheimer's disease (RR = 3.5; 95%CI: 2.2-5.5) and Parkinson's disease (RR = 2.6; 95%CI: 1.7-4.0), ischemic stroke (RR = 2.7; 95%CI: 2.3-3.2) and intracerebral hemorrhage (RR = 4.8; 95%CI: 1.8-12.9). | ||||||||||||||||||||
45 | Neurovascular injury with complement activation and inflammation in COVID-19 | 2022-07-07 | https://doi.org/10.1093/brain/awac151 | PMC9278212 | Myoung Hwa Lee | https://pubmed.ncbi.nlm.nih.gov/35788639/ | Injury to the microvasculature by immune complexes with complement activation is the key central event that results in breakdown of the blood–brain barrier, microthromboses, perivascular inflammation and neuronal injury. | ||||||||||||||||||||
46 | Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation | 2022-07-07 | https://doi.org/10.1016/j.cell.2022.06.0088 | AnthonyFernández-Castañeda | https://www.sciencedirect.com/science/article/pii/S0092867422007139 | COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID. | |||||||||||||||||||||
47 | Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study | 2022-07-20 | https://doi.org/10.1186/s13054-022-04092-z | Henriikka Ollila | https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-04092-z | ICU-treated COVID-19 patients, compared to patients with less severe acute COVID-19 or non-COVID controls, showed more severe long-term cognitive impairment. The groups differed (effect size η2p = 0.065, p = 0.004) in the total cognitive score, calculated from neuropsychological measures in three domains (attention, executive functions, and memory). Both ICU-treated (p = 0.011) and ward-treated patients (p = 0.005) performed worse than home-isolated patients. Among | |||||||||||||||||||||
48 | Prevalence of peripheral neuropathy and myopathy in patients post‐COVID‐19 infection | 2022-08-01 | https://doi.org/10.1111/1756-185X.14409 | PMC9538868 | Dalia S Saif | https://pmc.ncbi.nlm.nih.gov/articles/PMC9538868/ | The present study could indicate that muscle involvement and peripheral nerve affection are common problems even among asymptomatic patients after COVID‐19 infection, especially in the presence of any risk factors. The prevalence of peripheral neuropathy and myopathy in post‐COVID‐19 patients was 56.3% among all patients. | ||||||||||||||||||||
49 | Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients | 2022-08-17 | https://doi.org/10.1016/S2215-0366(22)00260-7 | Maxime Taquet | https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00260-7/fulltext | This analysis of 2-year retrospective cohort studies of individuals diagnosed with COVID-19 showed that.. the increased risk of psychotic disorder, cognitive deficit, dementia, and epilepsy or seizures persisted throughout. Children have a more benign overall profile of psychiatric risk than do adults and older adults, but their sustained higher risk of some diagnoses is of concern. The fact that neurological and psychiatric outcomes were similar during the delta and omicron waves indicates that the burden on the health-care system might continue even with variants that are less severe in other respects. | |||||||||||||||||||||
50 | Neurological Manifestations of Long COVID: A Single-Center One-Year Experience | 2022-09-01 | https://doi.org/10.2147/NDT.S387501 | Lisa Taruffi | https://www.tandfonline.com/doi/full/10.2147/NDT.S387501 | The majority of patients presenting persistent neurological symptoms (most frequently fatigue, cognitive disorders, and olfactory dysfunctions) developed a previous mild form of COVID-19. | |||||||||||||||||||||
51 | SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer’s-like neuropathology | 2022-09-06 | https://doi.org/10.1101/2022.01.31.478476 | Wei-Bin Shen | https://www.biorxiv.org/content/10.1101/2022.01.31.478476v3.abstract | our data suggest that SARS-CoV-2 invades the brain and activates an AD-like program (Alzheimer’s disease). SARS-CoV-2 infects mature neurons derived from inducible pluripotent stem cells from healthy and Alzheimer’s disease (AD) individuals through its receptor ACE2 and facilitator neuropilin-1. SARS-CoV-2 triggers AD-like gene programs in healthy neurons and exacerbates AD neuropathology. | |||||||||||||||||||||
52 | Association of COVID-19 with New-Onset Alzheimer’s Disease | 2022-09-13 | 10.3233/JAD-220717 | Wang, Lindsey | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220717 | In this retrospective cohort study of 6,245,282 older adults (age ≥65 years) who had medical encounters between 2/2020–5/2021, we show that people with COVID-19 were at significantly increased risk for new diagnosis of Alzheimer’s disease within 360 days after the initial COVID-19 diagnosis (hazard ratio or HR:1.69, 95% CI: 1.53–1.72), especially in people age ≥85 years and in women. | |||||||||||||||||||||
53 | Long-term cognitive performance and its relation to anti-inflammatory therapy in a cohort of survivors of severe COVID-19 | 2022-09-18 | https://doi.org/10.1016/j.bbih.2022.100513 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9482799/ | Harmke B Duindam | https://pubmed.ncbi.nlm.nih.gov/36159208/ | A relevant proportion of critically ill COVID-19 patients shows deficits in long-term cognitive functioning. Apart from more pronounced executive dysfunction, overall, anti-inflammatory therapy appeared not to affect long-term cognitive performance. After 6.5 ± 1.3 months, 27% of patients scored cognitively impaired. | ||||||||||||||||||||
54 | Long-term neurologic outcomes of COVID-19 | 2022-09-22 | https://doi.org/10.1038/s41591-022-02001-z | Xu, E. | https://www.nature.com/articles/s41591-022-02001-z | In the postacute phase of COVID-19, there was increased risk of an array of incident neurologic sequelae including ischemic and hemorrhagic stroke, cognition and memory disorders, peripheral nervous system disorders, episodic disorders (for example, migraine and seizures), extrapyramidal and movement disorders, mental health disorders, musculoskeletal disorders, sensory disorders, Guillain–Barré syndrome, and encephalitis or encephalopathy. We estimated that the hazard ratio of any neurologic sequela was 1.42 (95% confidence intervals 1.38, 1.47) | |||||||||||||||||||||
55 | SARS-CoV-2 promotes microglial synapse elimination in human brain organoids | 2022-10-05 | https://doi.org/10.1038/s41380-022-01786-2 | Samudyata, Oliveira, A.O. | https://www.nature.com/articles/s41380-022-01786-2 | Brain organoids infected with SARS-CoV-2 display disruption in circuit integrity via microglia-mediated synapse elimination and identifies a potential novel mechanism contributing to cognitive impairments in patients recovering from COVID-19. | |||||||||||||||||||||
56 | Cross-sectional analysis of clinical aspects in patients with long-COVID and post-COVID syndrome | 2022-10-13 | https://doi.org/10.3389/fneur.2022.979152 | Hannah Schulze | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.979152/full | Most long-COVID patients suffered from severe fatigue, with the female sex as an independent risk factor. At presentation, 93.1% suffered from fatigue, 82.2% from impaired concentration, and 79.2% from impaired memory, 53.5% had impaired sleep. | |||||||||||||||||||||
57 | Chronic Endothelial Dysfunction after COVID-19 Infection Shown by Transcranial Color-Coded Doppler: A Cross-Sectional Study | 2022-10-13 | https://doi.org/10.3390/biomedicines10102550 | Marino Marcic | https://www.mdpi.com/2227-9059/10/10/2550 | Subjects after COVID-19 infection had lower measured velocity parameters through MCA (middle cerebral artery) at rest period and after BHT (breath-holding test), lower relative increases of flow velocities after BHT, and lower BHI (breath-holding index). We showed that subjects, 300 days after COVID-19, still have impaired cerebral vasoreactivity measured by TCCD (transcranial color-coded Doppler) and they have chronic endothelial dysfunction. | |||||||||||||||||||||
58 | Neuropsychological impairment in post-COVID condition individuals with and without cognitive complaints | 2022-10-19 | https://doi.org/10.3389/fnagi.2022.1029842 | Mar Ariza | https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1029842/full | Our research suggests that patients with post-COVID conditions experience significant cognitive impairment. Scores on tests assessing global cognition, learning and long-term memory, processing speed, language and executive functions were significantly worse in the post-COVID condition group than in healthy controls. | |||||||||||||||||||||
59 | COVID-19 and Acute Neurologic Complications in Children | 2022-10-20 | https://doi.org/10.1542/peds.2022-058167 | James W. Antoon | https://publications.aap.org/pediatrics/article/150/5/e2022058167/188743/COVID-19-and-Acute-Neurologic-Complications-in?autologincheck=redirected | Neurologic complications are common in children hospitalized with COVID-19 and are associated with worse hospital outcomes. Of 15 137 children hospitalized with COVID-19, 1060 (7.0%) had a concurrent diagnosis of a neurologic complication. The most frequent neurologic complications were febrile seizures (3.9%), nonfebrile seizures (2.3%), and encephalopathy (2.2%). Hospital LOS, ICU admission, ICU LOS, 30 day readmissions, deaths, and hospital costs were higher in children with neurologic complications compared with those without complications. | |||||||||||||||||||||
60 | Brain cortical alterations in COVID-19 patients with neurological symptoms | 2022-10-20 | https://doi.org/10.3389/fnins.2022.992165 | Gretel Sanabria-Diaz | https://www.frontiersin.org/articles/10.3389/fnins.2022.992165/full | Our data suggest that viral-triggered inflammation leads to neurotoxic damage in some cortical areas during the acute phase of a COVID-19 infection in patients with neurological symptoms.Our findings revealed a lower cortical volume in COVID-19 patients’ orbitofrontal, frontal, and cingulate regions than in controls (p < 0.05). | |||||||||||||||||||||
61 | The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia | 2022-11-06 | 10.3233/ADR-220090 | Dubey, Souvik | https://content.iospress.com/articles/journal-of-alzheimers-disease-reports/adr220090 | The rapid progression of dementia, the addition of further impairments/deterioration of cognitive abilities, and the increase or new appearance of white matter lesion burden suggest that previously compromised brains have little defense to withstand a new insult (i.e., ‘second hit’ like infection/dysregulated immune response, and inflammation). | |||||||||||||||||||||
62 | Cognitive impairments in patients with subacute coronavirus disease: Initial experiences in a post-coronavirus disease clinic | 2022-11-08 | https://doi.org/10.3389/fnagi.2022.994331 | Jhin Goo Chang1 | https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.994331/full | Of the participants, 72.5% (n = 29) had impairments in at least one cognitive domain. Impairment in executive function was the most frequent (64.9%), followed by impairments in processing speed/attention (52.5%) and working memory (42.5%). | |||||||||||||||||||||
63 | The negative impact of COVID-19 on working memory revealed using a rapid online quiz | 2022-11-14 | https://doi.org/10.1371%2Fjournal.pone.0269353 | PMC9662713 | Heidi A. Baseler | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662713/ | Our main finding was a significant reduction in memory scores in all COVID groups (self-reported, positive-tested and hospitalized) compared to the non-COVID group. Memory scores for all COVID groups combined were significantly reduced compared to the non-COVID group in every age category 25 years and over, but not for the youngest age category (18–24 years old). We found that memory scores gradually increased over a period of 17 months post-COVID-19. However, those with ongoing COVID-19 symptoms continued to show a reduction in memory scores. | ||||||||||||||||||||
64 | Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids | 2022-11-20 | https://doi.org/10.1038/s41392-022-01241-2 | Yuxin Hou | https://www.nature.com/articles/s41392-022-01241-2 | Our results demonstrated that BA.2 replicated more efficiently while triggered lower levels of type I interferon response than that of SARS-CoV-2 WT, Delta, and BA.1 in both human forebrain and midbrain organoids. In addition, BA.2 triggered substantially higher levels of apoptosis in the infected human forebrain and midbrain organoids. Together, these findings suggest that BA.2 may be different from SARS-CoV-2 WT and previous variants in its capacity in targeting and causing diseases in the human brain. | |||||||||||||||||||||
65 | Susceptibility-Weighted Magnetic Resonance Imaging Highlights Brain Alterations in COVID Recovered Patients | 2022-11-22 | https://doi.org/10.1101/2022.11.21.22282600 | Sapna S Mishra | https://www.medrxiv.org/content/10.1101/2022.11.21.22282600v1 | COVID recovered subjects had significantly higher susceptibility imaging values in regions of the frontal lobe and the brain stem. The COVID group also demonstrated significantly higher fatigue levels than the HC group. This study suggests an association of Long COVID with prolonged effects on the brain. | |||||||||||||||||||||
66 | SARS-CoV-2 infection increases risk of intracranial hemorrhage | 2022-11-23 | https://doi.org/10.3389/fnhum.2022.991382 | Zuhair Hawsawi | https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2022.991382/full | Our correlative analysis indicates that SARS-Cov-2 infection increases the risk to develop ICH (intracranial hemorrhage. | |||||||||||||||||||||
67 | Brain functional connectivity alterations associated with neuropsychological performance 6–9 months following SARS-CoV-2 infection | 2022-12-02 | https://doi.org/10.1002/hbm.26163 | Philippe Voruz | https://onlinelibrary.wiley.com/doi/10.1002/hbm.26163 | The severity of the infection in the acute phase is a predictor of neuropsychological performance 6–9 months following SARS-CoV-2 infection. SARS-CoV-2 infection causes long-term memory and executive dysfunctions, related to large-scale functional brain connectivity alterations. | |||||||||||||||||||||
68 | Psychological consequences of long COVID: comparing trajectories of depressive and anxiety symptoms before and after contracting SARS-CoV-2 between matched long- and short-COVID groups | 2022-12-02 | doi:10.1192/bjp.2022.155 | Daisy Fancourt | https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/psychological-consequences-of-long-covid-comparing-trajectories-of-depressive-and-anxiety-symptoms-before-and-after-contracting-sarscov2-between-matched-long-and-shortcovid-groups/923140B3F95F1158C0CDC188002531AE | Depressive and anxiety symptoms increased immediately following the onset of infection in both long- and short-COVID groups. But the long-COVID group had substantially greater initial increases in depressive symptoms and heightened levels over 22 months follow-up. | |||||||||||||||||||||
69 | Severe COVID-19 is associated with molecular signatures of aging in the human brain | 2022-12-05 | https://doi.org/10.1038/s43587-022-00321-w | Maria Mavrikaki | https://www.nature.com/articles/s43587-022-00321-w | COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals... Aging-associated and cognitive decline-associated gene expression changes observed in individuals with COVID-19 may lead to increased rates of cognitive decline. | |||||||||||||||||||||
70 | SARS-CoV-2 infection and persistence in the human body and brain at autopsy | 2022-12-14 | https://doi.org/10.1038/s41586-022-05542-y | Sydney R. Stein | https://www.nature.com/articles/s41586-022-05542-y | We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection. Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic sites, including throughout the brain, as late as 230 days following symptom onset in one case. Despite extensive distribution of SARS-CoV-2 RNA throughout the body, we observed little | |||||||||||||||||||||
71 | SARS-CoV-2 infection and persistence throughout the human body and brain | 2022-12-14 | https://doi.org/10.21203/rs.3.rs-1139035/v1 | Daniel Chertow | https://www.researchsquare.com/article/rs-1139035/v1 | SARS-CoV-2 is widely distributed, even among patients who died with asymptomatic to mild COVID-19, and that virus replication is present in multiple extrapulmonary tissues early in infection. Further, we detected SARS-CoV-2 RNA in multiple anatomic sites, including regions throughout the brain, for up to 230 days following symptom onset....Our data prove that SARS-CoV-2 causes systemic infection and can persist in the body for months. | |||||||||||||||||||||
72 | Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge | 2022-12-20 | https://doi.org/10.1016/j.ajp.2022.103409 | Danmei He | https://www.sciencedirect.com/science/article/pii/S1876201822004075?via%3Dihub | Our findings suggest that COVID-19 survivors show long-term cognitive impairment in executive function, even at 15 months after discharge. We observed that COVID-19 survivors remain subtle cognitive impairment compared with healthy ones, especially on executive function at 15-month from hospital discharge. Additionally, the experience of ICU stay and self-perceived illness severity were associated with executive function. | |||||||||||||||||||||
73 | Cerebral Metabolic Rate of Glucose and Cognitive Tests in Long COVID Patients | 2022-12-22 | https://doi.org/10.3390/brainsci13010023 | Kamilla W. Miskowiak | https://www.mdpi.com/2076-3425/13/1/23 | Hypermetabolism in the cerebellum may reflect inefficient brain processing and play a role in cognitive impairments after COVID-19. The cognitive impaired patients showed higher cerebellar metabolism (p = 0.03), which correlated with more severe deficits in working memory and executive function (p = 0.03). | |||||||||||||||||||||
74 | Cognitive impairments among patients in a long-COVID clinic: Prevalence, pattern and relation to illness severity, work function and quality of life | 2022-12-31 | https://doi.org/10.1016/j.jad.2022.12.122 | K.W. Miskowiak | https://www.sciencedirect.com/science/article/pii/S0165032722014847?via%3Dihub | 44–53 % of the patients displayed clinically relevant cognitive impairments compared to HC and to their expected performance, respectively. Moderate to large impairments were seen in global cognition and in working memory and executive function, while mild to moderate impairments occurred in verbal fluency, verbal learning and memory. Hospitalised (n = 91) and non-hospitalised (n = 103) patients showed similar degree of cognitive impairments in analyses adjusted for age and time since illness. | |||||||||||||||||||||
75 | Two-year follow-up of brain structural changes in patients who recovered from COVID-19: A prospective study | 2023-01-01 | https://doi.org/10.1016/j.psychres.2022.114969 | Yanyao Du | https://www.sciencedirect.com/science/article/pii/S0165178122005601 | Longitudinal MRI data to explore brain structural changes of patients recovered from COVID-19 after two years.GMV (grey matter volume) recovered in the left frontal and temporal lobes, while persisted in the cerebellum, vermis, and right temporal lobe. | |||||||||||||||||||||
76 | Development of criteria for cognitive dysfunction in post-COVID syndrome: the IC-CoDi-COVID approach | 2023-01-01 | https://doi.org/10.1016/j.psychres.2022.115006 | Jordi AMatias-Guiu | https://www.sciencedirect.com/science/article/abs/pii/S0165178122005972 | According to the developed criteria, 41.2% and 17.3% of the sample were classified as having at least one cognitive domain impaired using -1 and -1.5 standard deviations as cutoff points. Cognitive impairment was associated with younger age and lower education levels, but not hospitalization. | |||||||||||||||||||||
77 | Memory impairment among recovered COVID-19 patients: the prevalence and risk factors, a retrospective cohort study | 2023-01-05 | https://doi.org/10.1002/jmv.28459 | Muayad A. Merza | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28459 | 34.49% have memory impairment after Covid19 recovery. Female gender, older age group, repeated exposure to COVID-19 infections, severe diseases, and exposure to multiple SARS-CoV-2 variants were independent risk factors of memory deficit in post-COVID-19 survivors with a p value of 0.0001, 0.02, 0.0001, 0.001, 0.0001 respectively. | |||||||||||||||||||||
78 | Subjective and Objective Cognitive Impairments in Non-Hospitalized Persons 9 Months after SARS-CoV-2 Infection | 2023-01-16 | https://doi.org/10.3390/v15010256 | Inge Kirchberger | https://www.mdpi.com/1999-4915/15/1/256 | Overall, 55.6% of the participants had at least a mild negative alteration in any cognitive test. The strongest impairments were found regarding memory functions (41.1% mild alterations, 6.2% distinct impairments) and verbal fluency (12.4% mild alterations, 5.4% distinct impairments). The number of complaints and depressiveness were significantly associated with subjective memory and concentration problems. | |||||||||||||||||||||
79 | Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers” | 2023-01-17 | https://doi.org/10.1186/s12883-023-03049-1 | Ted L. Rothstein | https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-023-03049-1 | The results demonstrate a statistically significant depletion of CGM (cortical grey matter) volume in 24 COVID-19 infected patients. Reduced CGM volume likely influences their long term neurological sequelae and may impair post COVID-19 patient’s quality of life and productivity. | |||||||||||||||||||||
80 | Two-Years Follow-Up of Symptoms and Return to Work in Complex Post-COVID-19 Patients | 2023-01-17 | https://doi.org/10.3390/jcm12030741 | Erika Van Wambeke | https://www.mdpi.com/2077-0383/12/3/741 | Despite exercise, respiratory, olfactory rehabilitations, cognition/speech therapy and/or psychological support, the more frequent self-reported symptoms (fatigue, neurocognitive disorders, muscles and joint pain) did not resolve. However, dyspnea, anxiety and chest pain were significantly reduced. Finally, 2/3 of the patients felt some degree of improvement and returned to work either partially or fully, but 1/3 remained complaining of symptoms and out of work as late as 22 months after COVID occurrence. | |||||||||||||||||||||
81 | Blood-brain barrier disruption in Long COVID-associated cognitive impairment | 2024-02-22 | https://doi.org/10.21203/rs.3.rs-2069710/v2 | Chris Greene | https://www.researchsquare.com/article/rs-2069710/v2 | Sustained systemic inflammation and persistent localised BBB dysfunction is a feature of long COVID-associated neurological impairment. Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in long COVID patients (n = 32), we observed elevated BBB permeability in distinct neuroanatomical regions including the frontal cortex, occipital lobe and temporal lobes which correlated with global brain volume and white matter volume deficits in patients with neurological impairment. | |||||||||||||||||||||
82 | Brain positron emission tomography (PET) and cognitive abnormalities one year after COVID-19 | 2023-01-24 | https://doi.org/10.1007/s00415-022-11543-8 | Roberta Ferrucci | https://link.springer.com/article/10.1007/s00415-022-11543-8 | Our study is the first to assess cognitive functions, brain metabolic activity and in a patient also amyloid PET one year after COVID-19, demonstrating that cerebral effects of COVID-19 can largely outlast the acute phase of the disease and even be followed by amyloid deposition. | |||||||||||||||||||||
83 | Neurocognitive and psychiatric symptoms following infection with COVID-19: Evidence from laboratory and population studies | 2023-01-28 | https://doi.org/10.1016/j.bbih.2023.100595 | Peter A. Hall | https://www.sciencedirect.com/science/article/pii/S2666354623000091 | Effects on flanker performance were significantly stronger among older adult women, and were accompanied by task-related changes cerebral oxygenation at the right superior frontal gyrus. Additionally, those with a symptomatic COVID-19 infection history showed evidence of amplified delay discounting. In Study 2, baseline symptomatic COVID-19 history was associated with self-reported cognitive dysfunction and a latent variable reflecting psychiatric symptoms of anxiety, depression and agitation at follow-up. Mediational analyses revealed evidence of cognitive mediation of clinically significant psychiatric outcomes: depression and generalized anxiety. | |||||||||||||||||||||
84 | Characteristics of subarachnoid hemorrhage associated with COVID-19 infection: A systematic review and descriptive analysis | 2023-02-01 | https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106904 | Mervyn Jun RuiLimMBBS, MRCS, MPH | https://www.sciencedirect.com/science/article/pii/S1052305722005961 | Subarachnoid hemorrhage (SAH) has been reported as a neurological manifestation in 0.1% of COVID-19 patients. The mortality rate of COVID-SAH patients was 40.8%, with a higher prevalence of severe-to-critical COVID-19 (100% versus 53.8%)`. | |||||||||||||||||||||
85 | A Sharp Rise in Autoimmune Encephalitis in the COVID-19 Era: A Case Series | 2023-02-05 | 10.7759/cureus.34658 | Pardis Saffari | https://www.cureus.com/articles/130722-a-sharp-rise-in-autoimmune-encephalitis-in-the-covid-19-era-a-case-series#!/ | Autoimmune encephalitis was very rare prior to the current pandemic. A sharp rise in cases has been observed from March to August of 2022 in Los Angeles. (The study) observation has important implications: (1) We may be entering an era of heightened autoimmune encephalitis. (2) These occurrences may be post-infectious in nature at this point of the pandemic. | |||||||||||||||||||||
86 | Cognitive deficit in post-acute COVID-19: an opportunity for EEG evaluation? | 2023-02-07 | https://doi.org/10.1007/s10072-023-06615-0 | Giovanni Furlanis | https://link.springer.com/article/10.1007/s10072-023-06615-0 | Out of the 90 patients attending the post-COVID neurology ambulatory service, twenty patients presenting brain fog at least 4 weeks after acute non-severe COVID-19 infection, and without previous history of epilepsy, were investigated with 19-channel EEG, Montreal Cognitive Assessment (MoCA), and magnetic resonance imaging (MRI). EEG was found altered in 65% of the sample, among which 69% presented a slowing activity and 31% were characterized by epileptic discharges principally in the frontal areas. | |||||||||||||||||||||
87 | Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei | 2023-02-13 | https://doi.org/10.1038/s41531-023-00467-3 | Aron Emmi | https://www.nature.com/articles/s41531-023-00467-3 | While the results of this study support the neuroinvasive potential of SARS-CoV-2 and characterize the role of brainstem inflammation in COVID-19, its potential implications for neurodegeneration, especially in Parkinson’s disease, require further investigations. | |||||||||||||||||||||
88 | The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia | 2023-02-14 | https://doi.org/10.3233/ADR-220090 | Dubey, Souvika | https://content.iospress.com/articles/journal-of-alzheimers-disease-reports/adr220090 | Fourteen COVID-19 survivors with pre-existing dementia. All developed or increased white matter hyperintensities that mimicked multiple sclerosis and small vessel disease. There was a significant increase in fatigue (p = 0.001) and depression (p = 0.016) scores following COVID-19. The rapid progression of dementia, the addition of further impairments/deterioration of cognitive abilities, and the increase or new appearance of white matter lesion burden suggest that previously compromised brains have little defense to withstand a new insult. | |||||||||||||||||||||
89 | Incidence of Epilepsy and Seizures Over the First 6 Months After a COVID-19 Diagnosis | 2023-02-21 | https://doi.org/10.1212/WNL.0000000000201595 | Maxime Taquet | https://n.neurology.org/content/100/8/e790 | The incidence of seizures within 6 months of COVID-19 was 0.81% (95% CI 0.75–0.88; HR compared with influenza 1.55 [1.39–1.74]). The incidence of epilepsy was 0.30% (0.26–0.34; HR compared with influenza 1.87 [1.54–2.28]). The HR of epilepsy after COVID-19 compared with influenza was greater in people who had not been hospitalized and in individuals younger than 16 years. | |||||||||||||||||||||
90 | Structural brain changes in patients with post-COVID fatigue: a prospective observational study | 2023-02-27 | https://doi.org/10.1016/j.eclinm.2023.101874 | Josephine Heine | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2823%2900051-2/fulltext | Our diffusion imaging analyses revealed aberrant fractional anisotropy of the thalamus. Diffusion markers correlated with fatigue severity, such as physical fatigue, fatigue-related impairment in everyday life (Bell score) and daytime sleepiness. Moreover, we observed shape deformations and decreased volumes of the left thalamus, putamen, and pallidum. These overlapped with the more extensive subcortical changes in MS and were associated with impaired short-term memory. | |||||||||||||||||||||
91 | Brain correlates of subjective cognitive complaints in COVID-19 survivors: A multimodal magnetic resonance imaging study | 2023-03-01 | https://doi.org/10.1016/j.euroneuro.2022.12.002 | Marco Paolini | https://www.sciencedirect.com/science/article/pii/S0924977X22009130 | Diffusion Tensor Imaging (DTI) analyses revealed widespread white matter disruption in the sub-group of cognitive complainers compared to the non-complainer one... Likewise, the Multivoxel Pattern Connectivity analysis (MVPA) revealed highly discriminant patterns of functional connectivity in resting-state among the two groups in the right frontal pole and in the middle temporal gyrus, suggestive of inefficient dynamic modulation of frontal brain activity and possible metacognitive dysfunction at rest. | |||||||||||||||||||||
92 | Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients | 2023-03-02 | https://doi.org/10.3389/fnins.2023.1125208 | Kiran Thapaliya | https://www.frontiersin.org/articles/10.3389/fnins.2023.1125208/full | Group comparisons with HC (Healthy controls) detected significantly larger volumes in ME/CFS for pons (p = 0.004) and whole brainstem (p = 0.01), and in long COVID for pons (p = 0.003), superior cerebellar peduncle (p = 0.009), and whole brainstem (p = 0.005)... In long COVID patients a strong negative relationship was detected between midbrain volume and “breathing difficulty.” Our study demonstrated an abnormal brainstem volume in both ME/CFS and long COVID consistent with the overlapping symptoms. | |||||||||||||||||||||
93 | The cognitive and psychiatric subacute impairment in severe Covid-19 | 2022-03-03 | https://doi.org/10.1038/s41598-022-07559-9 | Pedro J. Serrano-Castro | https://www.nature.com/articles/s41598-022-07559-9 | The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. | |||||||||||||||||||||
94 | Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutics | 2023-03-06 | https://doi.org/10.3390/cells12050816 | Albert Leng | https://www.mdpi.com/2073-4409/12/5/816 | Neurological manifestations of long COVID exist as a major complication of COVID-19 post-infection, affecting up to one third of patients with COVID symptoms lasting longer than four weeks. | |||||||||||||||||||||
95 | Association of SARS-CoV-2 Infection with Neurological Symptoms and Neuroimaging Manifestations in the Pediatric Population: A Systematic Review | 2023-03-09 | https://doi.org/10.21203/rs.3.rs-2653722/v1 | Angela T.H. Kwan | https://www.researchsquare.com/article/rs-2653722/v1 | Our findings revealed a high prevalence of immune-mediated patterns of disease among COVID-19 positive pediatric patients with neurocognitive abnormalities... 12.8% of hospitalized patients experienced neurocognitive impairments: MIS-C (24.2%), neuroinflammation (10.1%), and encephalopathy (8.1%) were the most common disorders; headaches (16.8%) and seizures (3.8%) were the most common symptoms. | |||||||||||||||||||||
96 | The effects of COVID-19 on cognitive performance in a community-based cohort: A COVID Symptom Study Biobank observational study | 2023-03-19 | https://doi.org/10.1101/2023.03.14.23287211 | Nathan J. Cheetham | https://www.medrxiv.org/content/10.1101/2023.03.14.23287211v1 | Cognitive deficits following SARS-CoV-2 infection were detectable nearly two years post infection, and largest for individuals with longer symptom durations, ongoing symptoms, and/or more severe infection. However, no such deficits were detected in individuals who reported full recovery from COVID-19. | |||||||||||||||||||||
97 | COVID-19 severity is related to poor executive function in people with post-COVID conditions | 2023-03-20 | https://doi.org/10.1007%2Fs00415-023-11587-4 | PMC10026205 | Mar Ariza | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10026205/ | The severe-critical group performed significantly worse than the control group in general cognition (Montreal Cognitive Assessment), executive function (Digit symbol, Trail Making Test B, phonetic fluency), and social cognition (Reading the Mind in the Eyes test). Patients with severe COVID-19 exhibited persistent deficits in executive function. | ||||||||||||||||||||
98 | SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures | 2023-03-21 | https://doi.org/10.1101/2023.03.20.533485 | Javier Jarazo | https://www.biorxiv.org/content/10.1101/2023.03.20.533485v1 | We confirm that SARS-CoV-2 has the ability to infect dopaminergic neurons, and that this infection triggers a series of mechanisms that lead to neurite fragmentation and neuronal loss. Furthermore, SARS-CoV-2 induced significant changes in the transcriptome. Pathways centered in membrane recycling, which play a major role in neurons by recycling synaptic vesicles, were among the most dysregulated. SARS-CoV-2 infection also induced dysregulation of dynein-mediated axonal transport, which coincides with previous knowledge that its impairment leads to neuronal death. | |||||||||||||||||||||
99 | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses | 2023-04-04 | https://doi.org/10.1101/2023.04.03.23287902 | Benedict D. Michael | https://www.medrxiv.org/content/10.1101/2023.04.03.23287902v1 | Tau and NfL remained elevated in convalescent sera, particularly following cerebrovascular and neuroinflammatory disorders. Inflammatory mediators were lower than acute levels in convalescent sera, but levels of CCL2, CCL7, IL-1RA, IL-2Rα, M-CSF, SCF, IL-16 and IL-18 in individual participants correlated with Tau levels even at this late time point. Neurological injury is common in the acute phase and persists late after COVID-19, and may be driven by a para-infectious process involving a dysregulated host response. | |||||||||||||||||||||
100 | SARS-CoV-2 Spike Protein Accumulation in the Skull-MeningesBrain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 | 2023-04-05 | https://doi.org/10.1101/2023.04.04.535604 | Zhouyi Rong | https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1.full.pdf | Our results revealed the accumulation of the spike protein in the skull marrow, brain meninges, and brain parenchyma. The injection of the spike protein alone caused cell death in the brain, highlighting a direct effect on brain tissue. Furthermore, we observed the presence of spike protein in the skull of deceased long after their COVID-19 infection, suggesting that the spike’s persistence may contribute to long-term neurological symptoms | |||||||||||||||||||||
101 | Brain disorders: Impact of mild SARS-CoV-2 may shrink several parts of the brain | 2023-04-06 | https://doi.org/10.1016/j.neubiorev.2023.105150 | Puranam Revanth Kumar | https://www.sciencedirect.com/science/article/pii/S0149763423001197 | When compared to a control group, people those who tested positive for COVID-19 had more brain shrinkage, grey matter shrinkage, and tissue damage. The damage occurs predominantly in areas of the brain that are associated with odour, ambiguity, strokes, reduced attention, headaches, sensory abnormalities, depression, and mental abilities for few months after the first infection. | |||||||||||||||||||||
102 | Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI | 2023-04-10 | https://doi.org/10.1038/s41598-023-32275-3 | Miloš Ajčević | https://www.nature.com/articles/s41598-023-32275-3 | In this study we identified a significative alteration of cerebral perfusion pattern in post-COVID-19 subjects who reported cognitive deficit by using a non-invasive ASL-MRI perfusion imaging technique and analysis. Particularly, significant hypoperfusion was observed predominantly in bilateral frontal, as well as in temporal, and parietal areas compared to healthy subjects, supporting the hypothesis of a large network dysfunction. | |||||||||||||||||||||
103 | Cognitive impairment in young adults with post COVID-19 syndrome | 2023-04-19 | https://doi.org/10.1038/s41598-023-32939-0 | Elena Herrera | https://www.nature.com/articles/s41598-023-32939-0 | Alteration in some of the tasks was observed in 85% of the participants. Both the presence and severity of impairments seem to have a relationship with age in the opposite direction to that expected, i.e. younger patients show impairment in some cognitive domain more frequently than older ones, and the severity of this impairment is greater in these younger patients. | |||||||||||||||||||||
104 | Changes in Brain Activation Patterns During Working Memory Tasks in People With Post-COVID Condition and Persistent Neuropsychiatric Symptoms | 2023-04-26 | https://doi.org/10.1212/WNL.0000000000207309 | Linda Chang | https://www.neurology.org/doi/10.1212/WNL.0000000000207309 | Participants with PCC had greater brain activation than the controls across the network... Compared with controls, participants with PCC also had poorer dexterity and endurance on the NIHTB-MB, higher T scores for negative affect and perceived stress, but lower T scores for psychological well-being on the NIHTB-EB, as well as more pain symptoms and poorer mental and physical health on measures from the PROMIS. Greater brain activation predicted poorer scores on measures that were abnormal on the NIHTB-EB. | |||||||||||||||||||||
105 | Single-Cell Transcriptomics Reveals Evidence of Endothelial Dysfunction in the Brains of COVID-19 Patients with Implications for Glioblastoma Progression | 2023-05-05 | https://doi.org/10.3390/brainsci13050762 | Abhimanyu Thakur | https://www.mdpi.com/2076-3425/13/5/762 | Single-cell transcriptomic analysis of the brain of COVID-19 patients revealed that endothelial cells had undergone significant transcriptomic changes, with several genes involved in immune responses and inflammation upregulated. The results indicate a significant overlap between COVID-19 and GBM (glioblastoma ) in the context of endothelial dysfunction, suggesting that there may be an endothelial dysfunction link connecting severe SARS-CoV-2 infection in the brain to GBM progression. | |||||||||||||||||||||
106 | Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection | 2023-05-05 | https://doi.org/10.1212/NXI.0000000000200097 | Yair Mina | https://nn.neurology.org/content/10/4/e200097 | The median time of evaluation was 9 months after COVID-19 (range 3–12 months), and most (11/12, 92%) had a history of only a mild infection. Immunophenotyping of CSF (Cerebrospinal fluid) compared with healthy volunteers showed that patients with neuro-PASC had lower frequencies of effector memory phenotype both for CD4+ T cells (p < 0.0001) and for CD8+ T cells (p = 0.002), an increased frequency of antibody-secreting B cells (p = 0.009), and increased frequency of cells expressing immune checkpoint molecules. | |||||||||||||||||||||
107 | SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model | 2023-05-09 | https://doi.org/10.1186/s42826-023-00157-4 | Na Yun Lee | https://labanimres.biomedcentral.com/articles/10.1186/s42826-023-00157-4 | Lethal conditions, such as severe body weight loss and encephalopathy, can occur in Omicron-infected K18-hACE2 mice. Our study reports, for the first time, that Omicron can induce brain infection with lymphoid depletion in the mouse COVID-19 model. | |||||||||||||||||||||
108 | Feasibility of diffusion-tensor and correlated diffusion imaging for studying white-matter microstructural abnormalities: Application in COVID-19 | 2023-05-10 | https://doi.org/10.1002/hbm.26322 | Nick Teller | https://onlinelibrary.wiley.com/doi/10.1002/hbm.26322 | Results suggest less restricted diffusion in the frontal lobe in COVID-19 patients, but also more restricted diffusion in the cerebellar white matter, in agreement with several existing studies highlighting the vulnerability of the cerebellum to COVID-19 infection. | |||||||||||||||||||||
109 | Brain fog in long COVID limits function and health status, independently of hospital severity and preexisting conditions | 2023-05-11 | https://doi.org/10.3389/fneur.2023.1150096 | Anna S. Nordvig | https://www.frontiersin.org/articles/10.3389/fneur.2023.1150096/full | A year after COVID-19 infection, BF (brain fog) persists in a third of patients. COVID-19 severity is not a predictive risk factor. Acute COVID-19 severity, age, and premorbid cardiopulmonary comorbidities did not differ between those with/without BF at 1 year. | |||||||||||||||||||||
110 | COVID-19 and cognitive function: Evidence for increased processing speed variability in COVID-19 survivors and multifaceted impairment with long-COVID symptoms | 2023-05-12 | https://doi.org/10.1192/j.eurpsy.2023.25 | Krupa Vakani | https://www.cambridge.org/core/journals/european-psychiatry/article/covid19-and-cognitive-function-evidence-for-increased-processing-speed-variability-in-covid19-survivors-and-multifaceted-impairment-with-longcovid-symptoms/AE8EFA3BF7DC84334EEBC3039427801C | The COVID group showed significantly larger intra-individual variability in processing speed, compared to the non-COVID group. The COVID sub-group also showed significantly larger intra-individual variability in processing speed, compared to their pre-COVID level; no significant change occurred in non-COVID participants over the same time scale. | |||||||||||||||||||||
111 | Objective and subjective cognition in survivors of COVID-19 one year after ICU discharge: the role of demographic, clinical, and emotional factors | 2023-05-15 | https://doi.org/10.1186/s13054-023-04478-7 | Marta Godoy-González | https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04478-7 | One-third of COVID-19 survivors suffered objective cognitive impairment with a frontal-subcortical dysfunction 12 months after ICU discharge. Emotional disturbances and perceived cognitive deficits were common. Almost one in three patients manifested cognitive complaints, and 22.5%, 26.3% and 27.5% reported anxiety, depression and post-traumatic stress disorder (PTSD) symptoms, respectively. | |||||||||||||||||||||
112 | Physical Function and Association with Cognitive Function in Patients in a Post-COVID-19 Clinic—A Cross-Sectional Study | 2023-05-18 | https://doi.org/10.3390/ijerph20105866 | Durita Viderø Gunnarsson | https://www.mdpi.com/1660-4601/20/10/5866 | Physical impairments were prevalent amongst patients assessed for post-COVID-19 condition regardless of their hospitalisation status and these were associated with more cognitive dysfunction. The prevalence of physical impairment ranged from 23% in functional exercise capacity to 59% in lower extremity muscle strength and function. There was no greater risk of physical impairment in previously hospitalised compared with the non-hospitalised patients. There was a weak to moderate association between physical and cognitive function. | |||||||||||||||||||||
113 | Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19 | 2023-05-21 | https://doi.org/10.1007/s00415-023-11767-2 | Damilola D. Adingupu | https://link.springer.com/article/10.1007/s00415-023-11767-2 | We detected that 24% of convalescent individuals’ post-COVID-19 infection had reduced StO2 in the brain and that this relates to reduced neurological function and quality of life. We believe that the hypoxia reported here will have health consequences for these individuals, and this is reflected in the correlation of hypoxia with greater symptomology. | |||||||||||||||||||||
114 | Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection | 2023-05-23 | https://doi.org/10.1073/pnas.2217232120 | Marvin Petersen | https://www.pnas.org/doi/10.1073/pnas.2217232120 | Our study suggests that a mild to moderate SARS-CoV-2 infection is associated with subtle microstructural alterations in the cerebral white matter beyond the stage of acute infection. | |||||||||||||||||||||
115 | Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms | 2023-05-31 | doi:10.1001/jamapsychiatry.2023.1321 | Joeffre Braga, BSc | https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2805366?resultClick=1 | Translocator protein distribution volume TSPO VT was elevated in 20 participants with persistent depressive and cognitive symptoms after initially mild to moderate COVID-19 infection when compared with 20 healthy controls, more prominently in the ventral striatum and dorsal putamen. The TSPO VT in the dorsal putamen of COVID-19 cases negatively correlated with motor speed. | |||||||||||||||||||||
116 | Cerebral blood flow in patients recovered from mild COVID-19 | 2023-06-02 | https://doi.org/10.1111/jon.13129 | Roger Newman-Norlund | https://onlinelibrary.wiley.com/doi/10.1111/jon.13129 | Twenty-eight cases with prior mild COVID-19 infection were compared with 28 controls. Whole-brain cerebral blood flow (CBF) (46.7 ± 5.6 vs. 49.3 ± 3.7, p = .05) and white matter (WM) CBF (29.3 ± 2.6 vs. 31.0 ± 1.6, p = .03) were noted to be significantly lower in COVID-19 cases as compared to controls. | |||||||||||||||||||||
117 | SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity | 2023-06-07 | https://doi.org/10.1126/sciadv.adg2248 | RAMÓN MARTÍNEZ-MÁRMOL | https://www.science.org/doi/10.1126/sciadv.adg2248 | We show that SARS-CoV-2 infection induces fusion between neurons and between neurons and glia in mouse and human brain organoids. We demonstrate that neuronal fusion is a progressive event, leads to the formation of multicellular syncytia, and causes the spread of large molecules and organelles. Last, using Ca2+ imaging, we show that fusion severely compromises neuronal activity. | |||||||||||||||||||||
118 | Neuropsychiatric disorders as risk factors and consequences of COVID-19: A Mendelian randomization study | 2023-06-25 | https://doi.org/10.1101/2021.06.29.21259609 | Yong Xiang | https://www.medrxiv.org/content/10.1101/2021.06.29.21259609v2 | We observed evidence that liability to COVID-19 or severe infection may be causally associated with higher risks of post-traumatic stress disorder (PTSD), bipolar disorder (BD) (especially BD II), schizophrenia (SCZ), attention deficit hyperactivity disorder (ADHD) and suicidal thought (ST) when compared to the general population. | |||||||||||||||||||||
119 | New-onset neurodegenerative diseases as long-term sequelae of SARS-CoV-2 infection: A systematic review and meta-analysis | 2023-07-02 | https://doi.org/10.1002/jmv.28909 | Masoud Rahmati | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28909 | The pooled analyses compared with control groups showed a significant association between SARS-CoV-2 infection and increased risk for new-onset Alzheimer's disease (HR = 1.50, 95% CI 1.22–1.85, I2 = 97%), dementia (HR = 1.66, 95% CI 1.42–1.94, I2 = 91%), and Parkinson's disease (HR = 1.44, 95% CI 1.06–1.95, I2 = 86%) among COVID-19 survivors. | |||||||||||||||||||||
120 | Neuropsychological measures of post-COVID-19 cognitive status | 2023-07-09 | https://doi.org/10.3389/fpsyg.2023.1136667 | Alessandra Lauria | https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2023.1136667/full | COVID-19 is capable of eliciting persistent measurable neurocognitive alterations particularly relevant in the areas of attention and working memory. When directly tested with the neuropsychological battery, 20.7% of the subjects had pathologic results. Specifically, 26.6%, 18.7% and 10.9% of subjects obtained either 0 or 1 equivalent scores on Trial Making, Digit Span Backwards and Frontal Assessment Battery tests respectively, showing impairment in selective and divided attention, working memory, short-term memory and executive functions. This was an unanticipated result in consideration of the relatively young age of the population examined and the good average level of education. | |||||||||||||||||||||
121 | Vagus nerve inflammation contributes to dysautonomia in COVID-19 | 2023-07-15 | https://doi.org/10.1007/s00401-023-02612-x | Marcel S. Woo | https://link.springer.com/article/10.1007/s00401-023-02612-x | Our data suggest that SARS-CoV-2 induces vagus nerve inflammation followed by autonomic dysfunction which contributes to critical disease courses and might contribute to dysautonomia observed in long COVID.Overall, our data show that the presence of SARS-CoV-2 RNA in the vagus nerve as well as vagus nerve inflammation and dysfunction are widespread in COVID-19. | |||||||||||||||||||||
122 | Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants | 2023-07-26 | https://doi.org/10.1038/s41467-023-40228-7 | Guilherme Dias de Melo | https://www.nature.com/articles/s41467-023-40228-7 | All SARS-CoV-2 variants are neuroinvasive, regardless of the clinical presentation they induce. Taken together, this confirms that neuroinvasion and anosmia are independent phenomena upon SARS-CoV-2 infection. | |||||||||||||||||||||
123 | Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions | 2023-08-03 | https://doi.org/10.1186/s12974-023-02861-3 | Alizé Proust | https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02861-3 | These results suggest that SARS-CoV-2 is neurotropic, with deleterious consequences for the blood–brain barrier integrity and central nervous system cells, which could underlie neurological disorders following SARS-CoV-2 infection. | |||||||||||||||||||||
124 | Neuronal and Glial Metabolite Abnormalities in Participants With Persistent Neuropsychiatric Symptoms After COVID-19: A Brain Proton Magnetic Resonance Spectroscopy Study | 2023-08-04 | https://doi.org/10.1093/infdis/jiad309 | Thomas Ernst | https://academic.oup.com/jid/article/228/11/1559/7237266?login=false | The findings from this study suggest that SARS-CoV-2 infection may cause neuronal injury or loss, as well as glial dysfunction or dystrophy, in frontal brain regions, which may contribute to the lingering neuropsychiatric symptoms in patients with PCCs. These alterations are still evident approximately 8 months after the acute infection. | |||||||||||||||||||||
125 | Levels of brain-derived neurotrophic factor (BDNF) among patients with COVID-19: a systematic review and meta-analysis | 2023-08-30 | https://doi.org/10.1007/s00406-023-01681-z | Arman Shafiee | https://pubmed.ncbi.nlm.nih.gov/37646849/ | In this study, we showed a significant dysregulation of BDNF (brain-derived neurotrophic factor) following COVID-19 infection. These findings may support the pathogenesis behind the long-lasting effects of this disease among infected patients. | |||||||||||||||||||||
126 | The Use of Quantitative Electroencephalography (QEEG) to Assess Post-COVID-19 Concentration Disorders in Professional Pilots: An Initial Concept | 2023-08-30 | https://doi.org/10.3390/brainsci13091264 | Marta Kopańska | https://www.mdpi.com/2076-3425/13/9/1264 | Comparison of the results between the study and control groups showed significantly higher values of all measurements of alpha, theta, and beta2 waves in the study group. In the case of the sensorimotor rhythm (SMR), the measurement results were significantly higher in the control group compared to the study group. Our study, conducted on pilots who had recovered from COVID-19, showed changes in the amplitudes of brain waves associated with relaxation and concentration. | |||||||||||||||||||||
127 | SARS-CoV-2 Spike amyloid fibrils specifically and selectively accelerates amyloid fibril formation of human prion protein and the amyloid β peptide | 2023-09-01 | https://doi.org/10.1101/2023.09.01.555834 | Johan NK Larsson | https://www.biorxiv.org/content/10.1101/2023.09.01.555834v1 | Our data suggest that cross-seeding by Spike-amyloid fibrils can be implicated in the increasing number of reports of CJD (Creutzfeldt-Jakob disease), AD (Alzheimer's Disease), and possibly other neurodegenerative diseases in the wake of COVID-19. | |||||||||||||||||||||
128 | Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death | 2023-09-12 | https://doi.org/10.1016/j.ebiom.2023.104784 | Florent Sauve | https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00350-X/fulltext | Putative GnRH neuron and tanycyte dysfunction following SARS-CoV-2 neuroinvasion could be responsible for serious reproductive, metabolic, and mental health consequences in long-COVID and lead to an increased risk of neurodevelopmental and neurodegenerative pathologies over time in all age groups. | |||||||||||||||||||||
129 | Navigating the Neurological Aftermath of COVID-19: An In-Depth Exploration | 2023-09-12 | https://doi.org/10.1101/2023.09.10.23295343 | Maliha Butt | https://www.medrxiv.org/content/10.1101/2023.09.10.23295343v1.full-text | Neurological complications in COVID-19 are diverse, ranging from mild symptoms like headache and anosmia to severe conditions including encephalitis and stroke. These complications can persist long after the acute infection. The overall incidence is around 25.2%. | |||||||||||||||||||||
130 | Association of Cognitive Deficits with Sociodemographic Characteristics among Adults with Post-COVID Conditions: Findings from the United States Household Pulse Survey | 2023-09-25 | https://doi.org/10.1101/2023.09.22.23295981 | Daniel J Wu | https://www.medrxiv.org/content/10.1101/2023.09.22.23295981v1 | Individuals with long COVID had significantly higher risk of experiencing cognitive deficits compared to those with no history of COVID infection. Furthermore, females, young adults, people with multiple races, or low levels of education attainment are at high risk of cognitive deficits if they experience long COVID. | |||||||||||||||||||||
131 | Prefrontal dysfunction in post-COVID-19 hyposmia: an EEG/fNIRS study | 2023-09-26 | https://doi.org/10.3389/fnhum.2023.1240831 | Livio Clemente | https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2023.1240831/full | This study showed that post-COVID-19 patients with persistent hyposmia present mild deficits in prefrontal function, even 4 months after the end of the infection. These deficits, although subtle, could have long-term implications for quality of life and cognitive wellbeing. We found that post-COVID-19 subjects performed worst at the MoCA screening test (p = 0.001), Sniffin's Sticks test (p < 0.001), and Stroop task response latency test (p < 0.001). | |||||||||||||||||||||
132 | Long COVID syndrome: psychological and sexual dysfunction among survivors of COVID-19 infection | 2023-10-01 | 10.1097/MS9.0000000000001153 | Khan, Sana A. | https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2023/10000/long_covid_syndrome__psychological_and_sexual.23.aspx | Females were 4.8 times more likely to experience neuropsychiatric symptoms than males, and the association was extremely significant (OR=4.851, 95% CI: 3.085–7.626, P<0.0001). An increase in age raised the odds of having sleep disturbances among the survivors by 2.7 times (OR=2.672, 95% CI: 2.654–2.684, P<0.0001). The odds of having sleep disturbances were three times more likely in female participants as compared to male participants (OR=3.00, 95% CI: 1.771–5.094, P<0.0001). | |||||||||||||||||||||
133 | Neurologic Effects of SARS-CoV-2 Transmitted among Dogs | 2023-10-13 | https://doi.org/10.3201/eid2911.230804 | Dong-Hwi Kim | https://wwwnc.cdc.gov/eid/article/29/11/23-0804_article | That evidence strongly suggests that even asymptomatic SARS-CoV-2 patients might have neuropathologic changes in their brains, which could develop into severe neurologic disorders later in life. | |||||||||||||||||||||
134 | Caveolin-1 mediates neuroinflammation and cognitive impairment in SARS-CoV-2 infection | 2023-10-19 | https://doi.org/10.1101/2023.10.18.563024 | Troy N. Trevino | https://www.biorxiv.org/content/10.1101/2023.10.18.563024v1 | We found that SARS-CoV-2 infection upregulated brain endothelial Cav-1. Moreover, SARS-CoV-2 infection increased brain endothelial cell vascular cell adhesion molecule-1 (VCAM-1) and CD3+ T cell infiltration of the hippocampus, a region important for short term learning and memory. Concordantly, we observed learning and memory deficits. | |||||||||||||||||||||
135 | MRI with generalized diffusion encoding reveals damaged white matter in patients previously hospitalized for COVID-19 and with persisting symptoms at follow-up | 2023-10-22 | https://doi.org/10.1093/braincomms/fcad284 | Deneb Boito | https://academic.oup.com/braincomms/article/5/6/fcad284/7326753 | In summary, these widespread alterations of white matter microstructure are indicative of vasogenic oedema, demyelination and axonal damage. These changes might be a contributing factor to the diversity of central nervous system symptoms that many patients experience after COVID-19. | |||||||||||||||||||||
136 | Serotonin reduction in post-acute sequelae of viral infection | 2023-10-26 | https://doi.org/10.1016/j.cell.2023.09.013 | Andrea C. Wong | https://www.cell.com/cell/pdf/S0092-8674(23)01034-6.pdf | We find that PASC are associated with serotonin reduction. Viral infection and type I interferon-driven inflammation reduce serotonin through three mechanisms: diminished intestinal absorption of the serotonin precursor tryptophan; platelet hyperactivation and thrombocytopenia, which impacts serotonin storage; and enhanced MAO-mediated serotonin turnover. Peripheral serotonin reduction, in turn, impedes the activity of the vagus nerve and thereby impairs hippocampal responses and memory. These findings provide a possible explanation for neurocognitive symptoms associated with viral persistence in Long COVID. | |||||||||||||||||||||
137 | ASSESSMENT AND CHARACTERIZATION OF COVID-19 RELATED COGNITIVE DECLINE: RESULTS FROM A NATURAL EXPERIMENT | 2023-11-07 | https://doi.org/10.1101/2023.11.06.23298101 | Zennur Sekendiz | https://www.medrxiv.org/content/10.1101/2023.11.06.23298101v1 | Longitudinal models indicated a significant decline in cognitive throughput ((B=-0.168, P=.001) following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors. The effect sizes were large; the observed changes in throughput were equivalent to 10.6 years of normal aging and a 59.8% increase in the burden of mild cognitive impairment. Cognitive decline worsened with coronavirus disease 2019 severity and was concentrated in participants reporting post-acute sequelae of SARS-CoV-2. | |||||||||||||||||||||
138 | Trajectory of post-COVID brain fog, memory loss, and concentration loss in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP multicenter study` | 2023-11-09 | https://doi.org/10.3389/fnhum.2023.1259660 | César Fernández-de-las-Peñas | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1259660/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE | A sample of 1,266 previously hospitalized patients due to COVID-19 during the first wave of the pandemic were assessed at 8.4 (T1), 13.2 (T2), and 18.3 (T3) months after hospital discharge. The prevalence of post-COVID brain fog was 8.37% (n = 106) at T1, 4.7% (n = 60) at T2, and 5.1% (n = 65) at T3, whereas the prevalence of post-COVID memory loss was 14.9% (n = 189) at T1, 11.4% (n = 145) at T2, and 12.12% (n = 154) at T3. | |||||||||||||||||||||
139 | Gray Matter Thickness and Subcortical Nuclear Volume in Men After SARS-CoV-2 Omicron Infection | 2023-11-30 | https://doi.org/10.1001/jamanetworkopen.2023.45626 | Yanyao Du | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812387 | The gray matter thickness in the left precuneus and right lateral occipital region and the ratio of the right hippocampus volume to the total intracranial volume were significantly reduced in the post-Omicron follow-up. | |||||||||||||||||||||
140 | SARS-CoV-2 Infection is Associated with an Increase in New Diagnoses of Schizophrenia Spectrum and Psychotic Disorder: A Study Using the US National COVID Cohort Collaborative (N3C) | 2023-12-05 | https://doi.org/10.1101/2023.12.05.23299473 | Asif Rahman | https://www.medrxiv.org/content/10.1101/2023.12.05.23299473v1 | We systematically analyzed the hazard rate of new-onset SSPD (Schizophrenia Spectrum and Psychotic Disorders) across three distinct time intervals: 0-21 days, 22-90 days, and beyond 90 days post-infection. COVID-19 positive patients consistently exhibited a heightened hazard ratio (HR) across all intervals [0-21 days (HR: 4.6; CI: 3.7-5.7), 22-90 days (HR: 2.9; CI: 2.3 -3.8), beyond 90 days (HR: 1.7; CI: 1.5-1.)]. Our data indicated that younger individuals face a heightened risk of SSPD after contracting COVID-19, a trend not observed in the ARDS (acute respiratory distress syndrome) and COVID-negative groups. | |||||||||||||||||||||
141 | Clinical characteristics of Long COVID patients presenting to a dedicated academic post-COVID-19 clinic in Central Texas | 2023-12-11 | https://doi.org/10.1038/s41598-023-48502-w | Rija Aziz | https://www.nature.com/articles/s41598-023-48502-w | Patients reported a median of 18 new symptoms following COVID-19 illness, the most common were fatigue (89%), forgetfulness or “brain fog” (89%), and difficulty concentrating (77%). MoCA (Montreal Cognitive Assessment) assessment demonstrated that 46% had mild cognitive dysfunction. PHQ-9 (Patient Health Questionnaire) testing revealed 42% had moderate to severe depression, and 38% had moderate to severe anxiety on the GAD-7 (Generalized Anxiety Disorder) assessment. | |||||||||||||||||||||
142 | Association between COVID-19 and outstanding academic performance at a Spanish university | 2023-12-13 | https://doi.org/10.1186/s13690-023-01225-w | Fares Amer | https://link.springer.com/article/10.1186/s13690-023-01225-w | A total of 658 (9.3%) participants were diagnosed with COVID-19, almost 4.0% of them achieved outstanding academic results, while uninfected students did so in 7.3%. SARS-CoV-2 infection was associated with a significant decrease in having outstanding academic results (OR = 0.57; 95% CI: 0.38–0.86). | |||||||||||||||||||||
143 | Neuropsychological, plasma marker, and functional connectivity changes in Alzheimer’s disease patients infected with COVID-19 | 2023-12-18 | https://doi.org/10.3389/fnagi.2023.1302281 | Shouzi Zhang | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1302281/full | For the 77 AD patients between the stages of pre and post COVID-19 infection, there were significant differences in cognitive function and psychobehavioral symptoms on the Montreal Scale (MoCA), the neuropsychiatric inventory (NPI), the clinician’s global impression of change (CIBIC-Plus), and the activity of daily living scale (ADL). The findings suggest clinical, cognitive, and neural alterations following COVID-19 infection in AD patients. | |||||||||||||||||||||
144 | Cognitive Symptoms of Post–COVID-19 Condition and Daily Functioning | 2023-12-20 | https://doi.org/10.1001/jamanetworkopen.2023.56098 | Abhishek Jaywant | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2815067 | In this survey study including 14 767 individuals with post–COVID-19 condition surveyed in late 2022 to early 2023, 57% reported experiencing cognitive symptoms daily, compared with 27% with prior SARS-CoV-2 infection who did not develop post–COVID-19 condition. In those with post–COVID-19 condition, cognitive symptoms were associated with greater levels of depressive symptoms, greater reported functional impairment, and lesser likelihood of full-time employment. | |||||||||||||||||||||
145 | SARS-CoV-2-Mimicking Pseudoviral Particles Accelerate α-Synuclein Aggregation In Vitro | 2023-12-22 | https://doi.org/10.1021/acschemneuro.3c00468 | Gianluca Zilio | https://pubs.acs.org/doi/10.1021/acschemneuro.3c00468 | We observe not only that SARS-CoV-2 viral spike protein and nucleocapsid protein can alone promote α-synuclein aggregation but also that the spike protein organization in a corona shape on the viral envelope may be crucial in triggering fast amyloid fibrils formation, thus possibly contributing to PD (Parkinson's Disease) pathogenesis. | |||||||||||||||||||||
146 | Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses | 2023-12-22 | https://doi.org/10.1038/s41467-023-42320-4 | Benedict D. Michael | https://www.nature.com/articles/s41467-023-42320-4 | Neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely. | |||||||||||||||||||||
147 | Decreased phrenic nerve compound muscle action potential, inspiratory muscle strength and exercise capacity after COVID-19 | 2023-12-27 | https://doi.org/10.3389/fneur.2023.1308443 | Karin Vonbank | https://www.frontiersin.org/articles/10.3389/fneur.2023.1308443/abstract | Respiratory muscle weakness and exercise capacity is associated with reduced phrenic nerve CMAP without signs of neuropathy. This indicates that muscle fiber pathology of the diaphragm may be one pathophysiological factor for the prolonged respiratory symptoms after COVID-19 infections. | |||||||||||||||||||||
148 | Preferential Impairment of Auditory Working Memory in Long COVID: An Observational Study of Undergraduate Medical Students | 2024-01-01 | https://doi.org/10.7759/cureus.51457 | Soumen Manna | https://www.cureus.com/articles/217296-preferential-impairment-of-auditory-working-memory-in-long-covid-an-observational-study-of-undergraduate-medical-students?score_article=true#!/ | In the current study, the overall WM functions (visual and auditory combined) and attention span did not differ between cases and controls. However, auditory WM performance was significantly impaired in patients compared with controls, indicating selective impairment of auditory WM in patients with long COVID. | |||||||||||||||||||||
149 | Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases | 2024-01-02 | https://doi.org/10.1007/s13365-023-01191-7 | Althaf Mahin | https://link.springer.com/article/10.1007/s13365-023-01191-7 | The meta-analysis revealed that top-enriched pathways were associated with neurological disorders, including Alzheimer’s (AD) and Parkinson’s disease (PD). Further analysis confirmed a direct correlation in the expression patterns of 24 proteins involved in Alzheimer’s and 23 proteins in Parkinson’s disease with COVID-19. Protein–protein interaction network and cluster analysis identified SNCA as a hub protein, a known biomarker for Parkinson’s disease, in both AD and PD. | |||||||||||||||||||||
150 | SARS-CoV-2’s brain impact: revealing cortical and cerebellar differences via cluster analysis in COVID-19 recovered patients | 2024-01-04 | https://doi.org/10.1007/s10072-023-07266-x | Angel Omar Romero-Molina | https://link.springer.com/article/10.1007/s10072-023-07266-x | We identified two groups of recovered patients based on a cluster analysis of the significant cortical thickness differences between patients and controls. Group 1 displayed significant cortical thickness differences in specific cerebral regions, while Group 2 exhibited significant differences in the cerebellum, though neither group showed cognitive deterioration at the group level... A trend could be observed towards a higher incidence of dysgeusia and anosmia was more prevalent in Group 1. This observation holds significance as Group 1 is characterized by cerebral atrophy | |||||||||||||||||||||
151 | Post-COVID cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction: national prospective study | 2024-01-05 | https://doi.org/10.21203/rs.3.rs-3818580/v1 | Benedict Michael | https://www.researchsquare.com/article/rs-3818580/v1 | When compared to normative age-matched data, these deficits were equivalent in magnitude to ageing from 50 to 70 years of age. Despite some improvement at the first follow-up, by the second there was a plateau in the cognitive recovery trajectory and there was evidence of ongoing neuronal and astrocytic injury one year after acute COVID-19, even in those without neurological complications, with demonstration of underpinning neuroanatomical substrates. | |||||||||||||||||||||
152 | Computable Phenotypes for Post-acute sequelae of SARS-CoV-2: A National COVID Cohort Collaborative Analysis | 2024-01-11 | https://doi.org/10.48550/arXiv.2303.12813 | PMC10785914 | Sarah Pungitore | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785914/ | We found several differences in symptom frequency between those with mild and moderate/severe COVID-19, including a higher frequency of certain gastrointestinal symptoms (such as constipation and diarrhea) in those with moderate/severe COVID-19 and a higher frequency of certain cardiopulmonary symptoms (such as chest pain and palpitations) in those with mild COVID-19. We also found a higher frequency of neuropsychiatric symptoms in chronic PASC following both mild and moderate/severe COVID-19 when compared to the other physiologic groups. A growing body of evidence suggests many individuals with PASC may experience the persistence of neuropsychiatric symptoms. | ||||||||||||||||||||
153 | Long-term risk of reduced cognitive performance and associated factors in discharged older adults with coronavirus disease 2019: A longitudinal prospective study | 2024-01-16 | https://doi.org/10.4235/agmr.23.0186 | Elif Demir | https://www.e-agmr.org/journal/view.php?doi=10.4235/agmr.23.0186 | On average, almost half of the survivors showed reduced cognitive performance 15 months after hospitalization for COVID-19. The results of this study provided evidence that older adults discharged following hospitalization for COVID-19 were at risk for long-term cognitive impairment. In addition to the previously established short-term predictors, we identified female sex and comorbidity burden as important risk factors for the long-term development of reduced cognitive performance. | |||||||||||||||||||||
154 | SARS-CoV-2 infection causes dopaminergic neuron senescence | 2024-01-17 | https://doi.org/10.1016/j.stem.2023.12.012 | Liuliu Yang | https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00442-3 | Midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection of DA neurons triggers an inflammatory and cellular senescence response. Our findings demonstrate that hPSC-derived DA neurons are susceptible to SARS-CoV-2, identify candidate neuroprotective drugs for COVID-19 patients, and suggest the need for careful, long-term monitoring of neurological problems in COVID-19 patients. | |||||||||||||||||||||
155 | A review of neuro-ophthalmic sequelae following COVID-19 infection and vaccination | 2024-01-17 | https://doi.org/10.3389/fcimb.2024.1345683 | Jane Shi | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1345683/full | The incidence of neuro-ophthalmic consequences following infection with COVID-19 is hundred-folds higher and associated with more harrowing systemic effects than vaccination against the virus. | |||||||||||||||||||||
156 | Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 | 2024-01-19 | https://doi.org/10.1038/s41598-024-52005-7 | Lucas Scardua-Silva | https://www.nature.com/articles/s41598-024-52005-7 | Our results suggest persistent cognitive impairment and subtle white matter abnormalities in individuals mildly infected without anxiety or depression symptoms.The quantitative analyses confirmed symptoms of fatigue (83% of participants), excessive somnolence (35%), impaired phonemic verbal fluency (21%), impaired verbal categorical fluency (13%) and impaired logical memory immediate recall (16%). The WM (white matter) analyses with DTI (diffusion tensor images) revealed higher axial diffusivity values in post-infected patients compared to controls. | |||||||||||||||||||||
157 | Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study | 2024-01-25 | https://doi.org/10.1016/j.eclinm.2024.102434 | Sijia Zhao | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00013-0/fulltext | Cognitive slowing was evident even on a 30-s task measuring simple reaction time (SRT), with patients with PCC responding to stimuli ∼3 standard deviations slower than healthy controls. 53.5% of patients with PCC's response speed was slower than 2 standard deviations from the control mean, indicating a high prevalence of cognitive slowing in PCC. | |||||||||||||||||||||
158 | Prevalence and Trajectories of Post-COVID-19 Neurological Manifestations: A Systematic Review and Meta-Analysis | 2024-01-25 | https://doi.org/10.1159/000536352 | Giorgia Giussani | https://karger.com/ned/article/58/2/120/895963/Prevalence-and-Trajectories-of-Post-COVID-19 | Neurological manifestations were prevalent during the acute phase of COVID-19 and over the 1-year follow-up period, with the highest overall prevalence estimates for fatigue, cognitive impairment, sleep disorders, anosmia/hyposmia, and headache. There was a downward trend over time, suggesting that neurological manifestations in the early post-COVID-19 phase may be long-lasting but not permanent. | |||||||||||||||||||||
159 | Attentional impairment and altered brain activity in healthcare workers after mild COVID-19 | 2024-02-01 | https://doi.org/10.1007/s11682-024-00851-4 | Keyi Lin | https://link.springer.com/article/10.1007/s11682-024-00851-4 | Selective impairment occurred in orienting and executive control networks, but not in alert network, in the patient group (healthcare workers (HCWs) with mild COVID-19), and widespread cognitive impairment encompassing general attention, memory, and executive dysfunction. Moreover, the patient group had significantly lower ALFF (amplitude of low-frequency fluctuation) values in the left superior and left middle frontal gyri than the HC (Healthy Control) group. SARS-COV-2 infection may have led to reduced brain activity in the left superior and left middle frontal gyri, thus impairing attentional orienting and executive control networks, which may explain the development of attentional deficits after COVID-19. | |||||||||||||||||||||
160 | Association Between COVID-19 and Neurological Diseases: Evidence from Large-Scale Mendelian Randomization Analysis and Single-Cell RNA Sequencing Analysis | 2024-02-01 | https://doi.org/10.1007/s12035-024-03975-2 | Lin Huang | https://link.springer.com/article/10.1007/s12035-024-03975-2 | The results showed that the COVID-19 is causally associated with manic (delta_elpd, − 0.1300, Z-score: − 2.4; P = 0.0082) and epilepsy (delta_elpd: − 2.20, Z-score: − 1.80; P = 0.038). However, no significant effects were observed for COVID-19 on other traits. This study shows causal links between SARS-CoV-2 infections and neurological disorders such as epilepsy and manic, supported by MR and scRNA-seq analysis. | |||||||||||||||||||||
161 | Predictors of non-recovery from fatigue and cognitive deficits after COVID-19: a prospective, longitudinal, population-based study | 2024-02-02 | https://doi.org/10.1016/j.eclinm.2024.102456 | Tim J. Hartung | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00035-X/fulltext | At baseline, 21% had fatigue and 23% had cognitive deficits.Participants with clinically relevant fatigue (at baseline) showed significant improvement in fatigue scores at follow-up and 46% had recovered from fatigue. Participants with cognitive deficits showed a significant improvement in cognitive scores and 57% had recovered from cognitive deficits. Fatigue and cognitive deficits are common sequelae after SARS-CoV-2 infection. These syndromes improved over time and about half of the patients recovered within two years. | |||||||||||||||||||||
162 | Temporal Association between COVID-19 Infection and Subsequent New-Onset Dementia in Older Adults: A Systematic Review and Meta-Analysis | 2024-02-06 | https://dx.doi.org/10.2139/ssrn.4716751 | Dan Shan | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4716751 | COVID-19 infection may be linked to a higher risk of NOD (new-onset dementia) in recovered old adults at the subacute and chronic stages following COVID-19 diagnosis. This risk appears to be on par with that associated with other respiratory infections.Patients with severe COVID-19, as classified by the American Thoracic Society guidelines, were significantly much more prone to developing NOD than those with non-severe infections (RR = 17.58, 95% CI 10.48–29.49). Cognitive impairment was nearly twice as likely in COVID-19 survivors compared to those uninfected (RR = 1.93, 95% CI 1.52–2.43). | |||||||||||||||||||||
163 | SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice | 2024-02-10 | https://doi.org/10.1101/2024.02.09.579589 | Haowen Qiao | https://www.biorxiv.org/content/10.1101/2024.02.09.579589v1 | By studying the K18-hACE2 infection model, we observed clear evidence of microvascular damage and breakdown of the blood-brain barrier (BBB). Mechanistically, SARS-CoV-2 infection caused pericyte damage, tight junction loss, endothelial activation and vascular inflammation, which together drive microvascular injury and BBB impairment. In addition, the blood-cerebrospinal fluid barrier at the choroid plexus was also impaired after infection. Therefore, cerebrovascular and choroid plexus dysfunctions are important aspects of COVID-19 and may contribute to the neurological complications both acutely and in long COVID. | |||||||||||||||||||||
164 | Neurological manifestations of SARS-CoV-2 infection in children in Taiwan: A cross-section, multicenter study | 2024-02-14 | https://doi.org/10.1016/j.jfma.2023.12.020 | Yen-Ju Chu | https://www.sciencedirect.com/science/article/pii/S0929664623005004 | Neurological complications are common in pediatric COVID-19. In hospitalized patients with neurological manifestations, severe neurological diagnosis was associated with behavior change, visual hallucination, decreased GCS, seizure with/without fever, myoclonic jerk, fatigue, and hypoglycemia at admission. Encephalitis/ADEM (acute disseminated encephalomyelitis) was the only risk factor for poor neurological outcomes at discharge in hospitalized patients. | |||||||||||||||||||||
165 | Acute neutrophilic vasculitis (leukocytoclasia) in 36 COVID-19 autopsy brains | 2024-02-15 | https://doi.org/10.1186/s13000-024-01445-w | Roy H. Rhodes | https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-024-01445-w | These findings are consistent with a more extensive small-vessel immune-related vasculitis in COVID-19 cases than in control cases. Tissue burden of acute neutrophilic vasculitis with leukocytoclasia was the same in control cases as a group, while it was significantly higher in COVID-19 cases. Both the tissue burden of acute neutrophilic vasculitis and the activation of complement components, including membrane attack complex, were significantly higher in microcirculatory channels in COVID-19 cohort brains than in historical controls. | |||||||||||||||||||||
166 | Differential associations between SARS-CoV-2 infection, perceived burden of the pandemic and mental health in the German population-based cohort for digital health research | 2024-02-15 | https://doi.org/10.1101/2024.02.14.24302768 | Lavinia A. Steinmann | https://www.medrxiv.org/content/10.1101/2024.02.14.24302768v1 | We observed an association of a past SARS-CoV-2 infection on deteriorated mental health related symptoms, whereas no association or interaction with burden of the pandemic occurred. The association was driven by participants with persistent symptoms 12 weeks after acute infection. On a symptom specific level, neuropsychiatric symptoms such as exhaustion and fatigue, concentration deficits as well as problems with memory function were the primary drivers of the association. | |||||||||||||||||||||
167 | Factors associated with older adults' cognitive decline 6 months after gamma-variant SARS-CoV-2 infection | 2024-02-15 | https://doi.org/10.3389/fneur.2024.1334161 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10902427/ | Vanessa Giffoni M N P Peixoto | https://pubmed.ncbi.nlm.nih.gov/38426174/ | After controlling for multiple variables, all the following factors resulted in greater odds of a deficient MoCA-B (Montreal Cognitive Assessment-Basic): COVID-19 6-months prior (OR, 2.44; p = 0.018), age (OR, 1.15; p < 0.001), lower income (OR, 0.36; p = 0.070), and overweight (OR, 2.83; p = 0.013). Further analysis pointed to individual characteristics in COVID-19-affected patients that could explain the severity of the cognitive decline: age (p = 0.015), lower income (p < 0.001), anxiety (p = 0.049), ageusia (p = 0.054), overweight (p < 0.001), and absence of cognitively stimulating activities (p = 0.062). | ||||||||||||||||||||
168 | New Insights into the Effects of SARS-CoV-2 on Metabolic Organs: A Narrative Review of COVID-19 Induced Diabetes | 2024-02-15 | https://doi.org/10.2147/DMSO.S454408 | Li L | https://www.dovepress.com/new-insights-into-the-effects-of-sars-cov-2-on-metabolic-organs-a-narr-peer-reviewed-fulltext-article-DMSO | Increased glucose concentration and insulin resistance levels were observed in the COVID-19 patients. COVID-19 patients with newly diagnosed diabetes may have worse clinical outcomes and can have serious consequences. SARS-CoV-2 can infect pancreatic β-cells, liver, muscle and adipose tissue, which in turn affects insulin secretion and induces insulin resistance. | |||||||||||||||||||||
169 | Post-COVID fatigue: Reduced quality-of-life associated with clinically relevant fatigue in mild disease courses | 2024-02-21 | https://doi.org/10.1080/09602011.2024.2314874 | Chiara Biserni | https://www.tandfonline.com/doi/full/10.1080/09602011.2024.2314874 | Our findings revealed the COVID group reported significantly higher levels of subjective fatigue compared to the control group. Moreover, there was a significant difference between experienced fatigue across the four severity groups. Participants who had a milder course of disease also experienced severe subjective fatigue. | |||||||||||||||||||||
170 | Insights into attention and memory difficulties in post-COVID syndrome using standardized neuropsychological tests and experimental cognitive tasks | 2024-02-22 | https://doi.org/10.1038/s41598-024-54613-9 | Sandra Arbula | https://www.nature.com/articles/s41598-024-54613-9 | Our findings revealed significant attention deficits in post-COVID patients across both neuropsychological measurements and experimental cognitive tasks, evidencing reduced performance in tasks involving interference resolution and selective and sustained attention. Mild executive function and naming impairments also emerged from the neuropsychological assessment. Notably, 61% of patients reported significant prospective memory failures in daily life. | |||||||||||||||||||||
171 | Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment | 2024-02-22 | https://doi.org/10.1038/s41593-024-01576-9 | Chris Greene | https://www.nature.com/articles/s41593-024-01576-9 | We show BBB disruption in patients with long COVID-associated brain fog. ... Peripheral blood mononuclear cells showed increased adhesion to human brain endothelial cells in vitro, while exposure of brain endothelial cells to serum from patients with long COVID induced expression of inflammatory markers. Together, our data suggest that sustained systemic inflammation and persistent localized BBB dysfunction is a key feature of long COVID-associated brain fog. | |||||||||||||||||||||
172 | Clinical characteristics of 4,520 paediatric patients infected with the SARS-CoV-2 omicron variant, in Xi'an, China | 2024-02-23 | https://doi.org/10.3389/fped.2024.1325562 | Jingwei Yue | https://www.frontiersin.org/articles/10.3389/fped.2024.1325562/full | A high incidence of convulsions is a typical characteristic of children infected with SARS-CoV-2. Five of the nine COVID-19 fatalities were associated with ANE (acute necrotising encephalopathy). This indicates that nervous system damage in children with SARS-CoV-2 infection is more significant. It is significantly different from that in adults who die of respiratory distress syndrome (white lungs). | |||||||||||||||||||||
173 | Neuroimaging findings in children with COVID-19 infection: a systematic review and meta-analysis | 2024-02-27 | https://doi.org/10.1038/s41598-024-55597-2 | Ghida Hasan Safadieh | https://www.nature.com/articles/s41598-024-55597-2 | The pooled proportion of pediatric COVID-19 patients with neurological symptoms and exhibiting abnormal neuroimaging findings was 43.74%. These findings were further categorized into neurovascular findings (8.22%), ADEM-like lesions (7.69%), encephalitic pattern (13.95%), myelitis (4.60%), transient splenial lesions (16.26%), and other abnormalities (12.03%). | |||||||||||||||||||||
174 | The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study | 2024-02-27 | https://doi.org/10.1186/s13052-024-01609-w | Ezgi Yangin Ergon | https://ijponline.biomedcentral.com/articles/10.1186/s13052-024-01609-w | SARS-CoV-2-positive infants had poorer psychomotor development index (PDI) scores and significantly greater mildly delayed performances (MDPs) at 18–24 months (PDI p = 0.05, MDPs p = 0.03, respectively). | |||||||||||||||||||||
175 | Cognition and Memory after Covid-19 in a Large Community Sample | 2024-02-29 | https://doi.org/10.1056/NEJMoa2311330 | Adam Hampshire | https://www.nejm.org/doi/10.1056/NEJMoa2311330 | We found that Covid-19 was associated with longer-term objectively measurable cognitive deficits. The difference of approximately −0.2 SD in the global cognitive score in the groups of participants who had symptoms that had resolved, as compared with the no–Covid-19 group, is classified as “small” according to Cohen’s effect sizes; this deficit would equate to a difference of −3 points on a typical IQ scale. | |||||||||||||||||||||
176 | Characteristic functional connectome related to Post-COVID-19 syndrome | 2024-02-29 | https://doi.org/10.1038/s41598-024-54554-3 | Julia Bungenberg | https://www.nature.com/articles/s41598-024-54554-3 | Alterations were mainly found in the brainstem, olfactory cortex, cingulate cortex, thalamus and cerebellum on average seven months after SARS-CoV-2 infection. Additionally, strong correlations between fatigue severity, cognitive functioning and daytime sleepiness from clinical scales and graph measures were observed. | |||||||||||||||||||||
177 | Prospective Memory Assessment before and after Covid-19 | 2024-02-29 | https://doi.org/10.1056/NEJMc2311200 | Merete Ellingjord-Dale | https://www.nejm.org/doi/10.1056/NEJMc2311200 | The adjusted mean EMQ (Everyday Memory Questionnaire) scores were numerically higher (indicating worse memory problems) after a positive test than after a negative test at all time points (at 0 to 1 month after a test, 0.66 vs. 0.60; at >1 to 3 months, 0.74 vs. 0.62; at >3 to 6 months, 0.72 vs. 0.62; at >6 to 9 months, 0.71 vs. 0.62; at >9 to 12 months, 0.75 vs. 0.63; at >12 to 18 months, 0.82 vs. 0.62; and at >18 to 36 months, 0.82 vs. 0.62) (Figure 1). | |||||||||||||||||||||
178 | Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings | 2024-02-29 | https://doi.org/10.1007/s10072-024-07427-6 | Sana Mohammadi | https://link.springer.com/article/10.1007/s10072-024-07427-6 | The most consistent findings from sMRI (structural MRI) were reduced gray matter volume (GMV) and cortical thickness (CTh) in cortical and subcortical regions. DTI (diffusion tensor imaging) frequently reveals increased mean diffusivity (MD), radial diffusivity (RD), and decreased fractional anisotropy (FA) in white matter tracts (WMTs) such as the corpus callosum, corona radiata, and superior longitudinal fasciculus. PWI (perfusion-weighted imaging) showed decreased cerebral blood flow (CBF) in the frontotemporal area, thalamus, and basal ganglia. | |||||||||||||||||||||
179 | High incidence of cerebrovascular lesions on magnetic resonance imaging in pediatric COVID-19 during omicron outbreak – A retrospective case series | 2024-03-02 | https://doi.org/10.1016/j.jfma.2024.02.015 | Yen-Ju Chu | https://www.sciencedirect.com/science/article/pii/S0929664624001414 | Among 31 pediatric patients with post-COVID-19 neurological symptoms, MRI abnormalities were observed in 15 (48.4%), predominantly encephalitis/encephalopathy (73.3%). The spectrum of neurological manifestations ranged from seizures to Alice in Wonderland syndrome, underscoring the diverse impact of COVID-19 on pediatric patients. | |||||||||||||||||||||
180 | Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease | 2024-03-04 | https://doi.org/10.2147/JIR.S460161 | Liu T | https://www.dovepress.com/role-of-inflammation-in-the-development-of-covid-19-to-parkinsons-dise-peer-reviewed-fulltext-article-JIR | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases the risk of PD (Parkinson's Disease) through an inflammatory environment and downregulation of ACE2, providing evidence for the molecular mechanism and targeted therapy associated with COVID-19 and PD. | |||||||||||||||||||||
181 | Post-COVID-19 physical and cognitive impairments and associations with quality of life: a cross-sectional study | 2024-03-05 | https://doi.org/10.3389/fspor.2024.1246585 | Fatemeh Rahimi | https://www.frontiersin.org/articles/10.3389/fspor.2024.1246585/full | On average 4 months after symptomatic COVID-19, post-COVID-19 participants had significant impairments in physical and cognitive functions compared to healthy matched controls that were significantly correlated with the quality of life. The results of the present study demonstrated significant impairments in physical functions in terms of endurance, fatigue, and physical performance among post-COVID-19 participants compared to healthy controls. In addition, cognitive functions, including global cognitive skills, subjective cognitive functions, information processing, executive function, and inhibitory control, and the quality of life were significantly impaired in post-COVID-19 individuals compared to controls. | |||||||||||||||||||||
182 | Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis | 2024-03-05 | https://doi.org/10.1016/j.genhosppsych.2024.02.009 | Christina van der Feltz-Cornelis | https://www.sciencedirect.com/science/article/pii/S0163834324000392 | Across all timepoints (3–24 months), the combined prevalence of mental health conditions and brain fog was 20·4% (95% CI 11·1%-34·4%), being lower among those previously hospitalised than in community-managed patients(19·5 vs 29·7% respectively; p = 0·047). Odds of brain fog significantly decreased with increasing vaccination rates (p = ·000). | |||||||||||||||||||||
183 | Accelerated brain age in young to early middle-aged adults after mild to moderate COVID-19 infection | 2024-03-07 | https://doi.org/10.1101/2024.03.05.24303816 | Shelli R Kesler | https://www.medrxiv.org/content/10.1101/2024.03.05.24303816v1 | We calculated Brain Age Gap (BAG), which is the difference between brain age and chronological age, in a cohort of 25 mild to moderate COVID-19 survivors (did not experience breathlessness, pneumonia, or respiratory/organ failure) and 24 non-infected controls using magnetic resonance imaging (MRI). BAG was significantly higher in the COVID-19 group by 2.65 years. Additionally, 80% of the COVID-19 group demonstrated an accelerated BAG compared to 13% in the control group. Accelerated BAG was significantly correlated with lower cognitive function. | |||||||||||||||||||||
184 | Blood Markers Show Neural Consequences of LongCOVID-19 | 2024-03-08 | https://doi.org/10.3390/cells13060478 | Norina Tang | https://www.mdpi.com/2073-4409/13/6/478# | This study shows chronic peripheral inflammation with increased stress after COVID-19 infection. Additionally, differentially expressed nEV (neuronal-enriched extracellular vesicles) neurodegenerative proteins were identified in people recovering from COVID-19 regardless of persistent symptoms. Both brain-derived neurotrophic factor and cortisol were significantly elevated in nLongC (LongCOVID with neurological impairment) and Cov (COVID-19 survivors without any LongCovid symptoms) compared to HC (healthy controls). | |||||||||||||||||||||
185 | Current clinical findings of acute neurological syndromes after SARS-CoV-2 infection | 2024-03-09 | https://doi.org/10.1002/mco2.508 | Minjin Wang | https://onlinelibrary.wiley.com/doi/10.1002/mco2.508 | The Omicron variant, distinguished by heightened neurotropism, penetrates the CNS via the olfactory bulb. This direct invasion induces inflammation and neuronal damage, emphasizing the need for vigilance regarding potential neurological complications. Our multicenter study represents a groundbreaking revelation, documenting the definite presence of SARS-CoV-2 in the cerebrospinal fluid (CSF) of a significant proportion of Neuro-COVID patients. | |||||||||||||||||||||
186 | SARS-CoV2 evokes structural brain changes resulting in declined executive function | 2024-03-12 | https://doi.org/10.1371/journal.pone.0298837 | Andreas Schicho | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0298837 | Changes in gray matter volume and white matter tracts included mainly areas involved in networks of executive control and language. Alterations strongly focused on grey matter of the frontal—basal ganglia—thalamus network and temporal areas, as well as fiber tracts connecting these areas. A decline in executive function and especially verbal fluency was found in acute patients, partially persisting in recovered. | |||||||||||||||||||||
187 | Prevalence and trajectories of neuropsychological post-COVID-19 symptoms in initially hospitalized patients | 2024-03-12 | https://doi.org/10.2340/jrm.v56.25315 | Simona Klinkhammer | https://medicaljournalssweden.se/jrm/article/view/25315 | Study of 205 patients initially hospitalized with SARS-CoV-2 (COVID-19). Validated questionnaires were administered at 9 months (T1) and 15 months (T2) post-hospital discharge. Approximately 50% experienced high cognitive complaints at T1 and T2, while severe fatigue affected 52.5% at T1 and 55.6% at T2. Clinically relevant insomnia scores were observed in 25% of patients at both time-points. Most symptoms remained stable, with 59.2% of patients experiencing at least 1 persistent symptom. In addition, 31.5% of patients developed delayed-onset symptoms. | |||||||||||||||||||||
188 | Neurofilament light chain and glial fibrillary acid protein levels are elevated in post-mild COVID-19 or asymptomatic SARS-CoV-2 cases | 2024-03-18 | https://doi.org/10.1038/s41598-024-57093-z | Domenico Plantone | https://www.nature.com/articles/s41598-024-57093-z | At the subsequent follow-up, sNfL and sGFAP levels showed a significant decrease, although they were still higher than HCs (Healthy Controls). Our results suggest an ongoing damage involving neurons and astrocytes after SARS-Cov2 negativization, which reduce after ten months even if still evident compared to HCs. | |||||||||||||||||||||
189 | Long-term risk of psychiatric disorder and psychotropic prescription after SARS-CoV-2 infection among UK general population | 2024-03-21 | https://doi.org/10.1038/s41562-024-01853-4 | Yunhe Wang | https://www.nature.com/articles/s41562-024-01853-4 | Compared with contemporary controls, infected participants had higher subsequent risks of incident mental health at 1 year (hazard ratio (HR): 1.54), including psychotic, mood, anxiety, alcohol use and sleep disorders, and prescriptions for antipsychotics, antidepressants, benzodiazepines, mood stabilizers and opioids. Risks were higher for hospitalized individuals (2.17) than those not hospitalized (1.41), and were reduced in fully vaccinated people (0.97) compared with non-vaccinated or partially vaccinated individuals (1.64). Breakthrough infections showed similar risk of psychiatric diagnosis (0.91) but increased prescription risk (1.42) compared with uninfected controls. | |||||||||||||||||||||
190 | Hippocampal neurometabolic and structural changes from pre-to post-COVID-19: A case-series study | 2024-03-22 | https://doi.org/10.1016/j.mri.2024.03.032 | Wouter A.J. Vints | https://www.sciencedirect.com/science/article/pii/S0730725X24000882 | SARS-CoV-2 infection may cause changes to the neurometabolic state of the hippocampus, indicating neuroinflammation and metabolic abnormalities that may persist beyond the acute phase of the disease. | |||||||||||||||||||||
191 | Brain magnetic resonance imaging findings in children with neurological complications of coronavirus disease 2019 (Omicron variant): a multicenter retrospective observational study | 2024-03-28 | https://doi.org/10.1007/s00247-024-05908-6 | Chun Zhao | https://link.springer.com/article/10.1007/s00247-024-05908-6 | Overall, these data highlighted five neuroimaging patterns associated with the outbreak of the SARS-CoV-2 Omicron variant, with acute necrotizing encephalopathy being the most common of these neuroimaging findings.Brain MRI was performed 1–12 days following the onset of neurological symptoms, which revealed acute neuroimaging findings in 74.2% (69/93) of cases, including evidence of acute necrotizing encephalopathy (33/69, 47.8%), encephalitis (31/69, 44.9%), reversible splenial lesion syndrome (3/69, 4.3%), reversible posterior leukoencephalopathy (1/69, 1.4%), and hippocampal atrophy (1/69, 1.4%). | |||||||||||||||||||||
192 | Brain temperature and free water increases after mild COVID-19 infection | 2024-03-28 | https://doi.org/10.1038/s41598-024-57561-6 | Ayushe A. Sharma | https://www.nature.com/articles/s41598-024-57561-6 | We found post-COVID-19 brain temperature elevations and edema in the primary and secondary olfactory cortices. This supports the notion that even mild COVID-19 infections can cause long-term changes in the brain's structure and physiological function. Furthermore, our findings indicate that mild COVID-19 may lead to subtle neuroinflammatory changes and associated symptoms. | |||||||||||||||||||||
193 | Reduced Cortical Thickness Correlates of Cognitive Dysfunction in Post-COVID-19 Condition: Insights from a Long-Term Follow-up | 2024-04-01 | https://doi.org/10.3174/ajnr.A8167 | Rosalia Dacosta-Aguayo | https://www.ajnr.org/content/early/2024/04/04/ajnr.A8167 | Our findings suggest that cognitive impairment in individuals with the post-COVID-19 condition is associated with long-term alterations in the structure of the brain. According to the Frascati criteria, more than one-half of the participants had deficits in the attentional (55%, n = 29) and executive (59%, n = 31) domains, while 40% (n = 21) had impairment in the memory domain. We observed that reduced cortical thickness in the left parahippocampal region (t(48) = 2.28, P = .03) and the right caudal-middle-frontal region (t(48) = 2.20, P = .03) was positively correlated with the memory domain. | |||||||||||||||||||||
194 | Fatigue in healthcare workers with mild COVID-19 survivors in Indonesia | 2024-04-01 | https://doi.org/10.52225/narra.v4i1.656 | Bintang YM. Sinaga | https://narraj.org/main/article/view/656 | A total of 100 healthcare workers of mild COVID-19 survivors were included. Mild to moderate fatigue was found in 23% of healthcare workers and only 1% experienced severe fatigue. However, a significant association was observed between age (p=0.021), the presence of PCS (Post-COVID syndrome) (p=0.041), and the number of PCS symptoms (p=0.047) with fatigue incidence. | |||||||||||||||||||||
195 | Brain and cognitive changes in patients with long COVID compared with infection-recovered control subjects | 2024-04-02 | https://doi.org/10.1093/brain/awae101 | Víctor M Serrano del Pueblo | https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awae101/7638850?redirectedFrom=fulltext&login=false | Patients with neurological Long COVID suffer brain changes, especially in several white matter areas, and these are associated with impairments of specific cognitive functions. The mean global cognitive function of patients with Long COVID assessed by ACE III screening test was significantly below the infection recovered-controls. We observed that 48% of patients with Long COVID had episodic memory deficit, with 27% also impaired overall cognitive function, especially attention, working memory, processing speed and verbal fluency. Compared to infection recovered controls, patients had thinner cortex in a specific cluster centred on the left posterior superior temporal gyrus. In addition, lower fractional anisotropy (FA) and higher radial diffusivity (RD) were observed in widespread areas of the patients’ cerebral white matter relative to these controls. | |||||||||||||||||||||
196 | Symptoms before and after COVID-19: a population and case-control study using prospective data | 2024-04-04 | https://doi.org/10.1183/13993003.01853-2023 | Carole H. Sudre | https://publications.ersnet.org/content/erj/early/2024/03/21/1399300301853-2023 | Two-thirds (910 of 1350 [67.4%]) of individuals with long illness were asymptomatic beforehand. However, 440 (32.6%) had baseline symptoms, versus 255 (18.9%) of 1350 individuals with short illness (p<0.0001). Baseline symptoms increased the odds ratio for long illness (2.14 [CI: 1.78; 2.57]). | |||||||||||||||||||||
197 | Similarities between long COVID and cognitive impairment and potential implications; Results from the 2022 BRFSS | 2024-04-05 | https://doi.org/10.1101/2024.04.02.24305215 | Mary Adams | https://www.medrxiv.org/content/10.1101/2024.04.02.24305215v1 | Prevalence of long COVID was 7.4% (95% CI 7.3-7.6) and CI was 13.4% (13.2-13.6) with both rates higher among women, ages 18-64 years, Hispanics, American Indians, ever smokers, those with depression, e-cigarette users, and those with more of the co-morbidities of diabetes, asthma, COPD, and obesity. The strong association between long COVID and CI was confirmed. | |||||||||||||||||||||
198 | Long-Term Growth and Neurodevelopmental Outcomes of Neonates Infected with SARS-CoV-2 during the COVID-19 Pandemic at 18–24 Months Corrected Age: A Prospective Observational Study | 2024-04-05 | https://doi.org/10.1159/000537803 | Medha Goyal | https://karger.com/neo/article/doi/10.1159/000537803/898054/Long-Term-Growth-and-Neurodevelopmental-Outcomes | Neonates infected with SARS-CoV-2 have an increased risk of developmental delays in expressive language, fine motor, and receptive language skills at 18–24 months of age. The severity of delays is predominantly mild.Mild delay in either motor, cognitive, or language domains was found in 9 (45%) children and moderate delay in 2 (10%) | |||||||||||||||||||||
199 | Severe Neurological Manifestation Associated With Coronavirus Disease 2019 in Children During the Omicron Variant-Predominant Period | 2024-04-06 | https://doi.org/10.1016/j.pediatrneurol.2024.04.004 | Minhye Kim | https://www.pedneur.com/article/S0887-8994(24)00131-0/abstract#%20 | This study shows that severe neurological complications in pediatric patients with the Omicron variant of SARS-CoV-2 occur infrequently but may lead to significant morbidity and mortality, especially among those with pre-existing neurological disabilities and unvaccinated individuals. Among the 17 patients, 11 had pre-existing neurological disabilities and nine met the criteria for multisystem inflammatory syndrome in children (MIS-C). Five patients survived with new neurological deficits at the one-year follow-up, and three died, all of whom had underlying neurological disabilities. | |||||||||||||||||||||
200 | SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway | 2024-04-08 | https://doi.org/10.1186/s12987-024-00533-9 | Shigeru Yamada | https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-024-00533-9 | These results demonstrate a novel infection model of the original SARS-CoV-2 strain in human iPSC-BMELCs (iPSC derived brain microvascular endothelial like cells). Specifically, SARS-CoV-2 can infect in BMECs (brain microvascular endothelial cells) and cause permeability impairment. BBB (blood–brain barrier) dysfunction may explain the invasion of SARS-CoV-2 into the brain and various neurological symptoms observed in patients with COVID-19. | |||||||||||||||||||||
201 | Microgliosis, astrogliosis and loss of aquaporin-4 polarity in frontal cortex of COVID-19 patients | 2024-04-11 | https://doi.org/10.1101/2024.04.10.588851 | Antonia Beiersdorfer | https://www.biorxiv.org/content/10.1101/2024.04.10.588851v1 | Our data suggest neuroinflammation upon SARS-CoV-2 infection including microgliosis and astrogliosis, including loss of AQP4 polarity. The most striking difference between astrocytes in COVID-19 patients and controls was found by anti-aquaporin-4 (AQP4) staining. In COVID-19 patients, a large number of gray matter astrocytes showed an increase in AQP4. In addition, AQP4 polarity was lost and AQP4 covered the entire cell, including the cell body and all cell processes, while in controls, AQP4 immunostaining was mainly detected in endfeet around blood vessels and did not visualize the cell body. | |||||||||||||||||||||
202 | Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19 | 2024-04-15 | https://doi.org/10.1016/j.jneuroim.2024.578327 | Nathália Gualberto Souza-Silva | https://www.jni-journal.com/article/S0165-5728(24)00045-6/abstract | Individuals who experience mild COVID-19 can suffer from long-lasting cognitive symptoms. Notably, 26% of these individuals experience difficulties with visuospatial abilities six months after infection. However, among those who initially exhibited visuoconstructive impairments, 66% showed improvement or complete reversal over time. | |||||||||||||||||||||
203 | COVID-19-associated cerebral microbleeds in the general population | 2024-04-15 | https://doi.org/10.1093/braincomms/fcae127 | Malini V Sagar | https://academic.oup.com/braincomms/article/6/3/fcae127/7645966?login=false | COVID-19 was associated with significantly greater odds of having cerebral microbleeds on MRI [odds ratio 2.66 (1.23–5.76, 95% confidence interval)], increasingly so when patients with dementia and hospitalized patients were excluded. Our findings indicate that cerebral microbleeds may be associated with COVID-19 infections. | |||||||||||||||||||||
204 | SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids | 2024-04-17 | https://doi.org/10.1101/2024.04.16.589036 | Mathilde Colinet | https://www.biorxiv.org/content/10.1101/2024.04.16.589036v1 | local and minor infectivity of SARS-CoV2 in the brain may induce widespread adverse effects and may lead to resilience of dysregulated neurons and astrocytes within an inflammatory environment. Our study shows that SARS-CoV2 infects astrocytes, deep layer projection neurons, upper callosal neurons and interneurons of the cortex and trigger astrocyte reactive states and overall inflammation and cell survival pathways. | |||||||||||||||||||||
205 | Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [11C]PBR28 PET correlates with vascular disease measures | 2024-04-18 | https://doi.org/10.1016/j.bbi.2024.04.015 | Michael B. VanElzakker | https://www.sciencedirect.com/science/article/abs/pii/S0889159124003593 | We found significantly increased neuroinflammation in PASC versus controls across a wide swath of brain regions including midcingulate and anterior cingulate cortex, corpus callosum, thalamus, basal ganglia, and at the boundaries of ventricles. We also collected and analyzed peripheral blood plasma from the PASC individuals and found significant positive correlations between neuroinflammation and several circulating analytes related to vascular dysfunction. | |||||||||||||||||||||
206 | Increased frequency and mortality in persons with neurological disorders during COVID-19 | 2024-04-20 | https://doi.org/10.1093/brain/awae117 | Candace M Marsters | https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awae117/7654052?redirectedFrom=fulltext&login=false | The risk of death was significantly greater in the SARS-CoV-2 RNA-positive (2,140 per 100,000 person years) compared to RNA-negative (922 per 100,000 person years) over a follow-up of 9 months. There was also a significantly increased risk for diagnosis of new neurological sequelae during the acute time phase after COVID-19 including encephalopathy (2·0, 1·10-3·64), dementia (1·36, 1·07-1·73), seizure (1·77, 1·22-2·56), and brain fog (1·96, 1·20-3·20). These risks persisted into the post-acute phase after COVID-19 during which inflammatory myopathy (2·57, 1·07-6·15) and coma (1·87, 1·22-2·87) also became significantly increased. | |||||||||||||||||||||
207 | Increased frequency and mortality in persons with neurological disorders during COVID-19 | 2024-04-20 | https://doi.org/10.1093/brain/awae117 | Candace M Marsters | https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awae117/7654052?redirectedFrom=fulltext&login=false | There was also a significantly increased risk for diagnosis of new neurological sequelae during the acute time phase after COVID-19 including encephalopathy (2·0, 1·10-3·64), dementia (1·36, 1·07-1·73), seizure (1·77, 1·22-2·56), and brain fog (1·96, 1·20-3·20). These risks persisted into the post-acute phase after COVID-19 during which inflammatory myopathy (2·57, 1·07-6·15) and coma (1·87, 1·22-2·87) also became significantly increased. Thus, persons with SARS-CoV-2 infection and premorbid neurological disorders are at greater risk of death while SARS-CoV-2 infection was complicated by increased risk of new onset neurological disorders in both the acute and post-acute phases of COVID-19. | |||||||||||||||||||||
208 | Cognitive performance of post-covid patients in mild, moderate, and severe clinical situations | 2024-04-26 | https://doi.org/10.1186/s40359-024-01740-7 | Antonio de Pádua Serafim | https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-024-01740-7 | We assessed intellectual quotient (IQ), attention, memory, processing speed, visual-constructive ability, as well as symptoms of depression, anxiety, and stress, at least eighteen months after infection. Cognitive difficulties were present in all three groups: mild (n = 12, 11.7%), moderate (n = 40, 39.2%), and severe (n = 48, 48.9%). | |||||||||||||||||||||
209 | Long COVID: plasma levels of neurofilament light chain in mild COVID-19 patients with neurocognitive symptoms | 2024-04-27 | https://doi.org/10.1038/s41380-024-02554-0 | Elisa Gouvea Gutman | https://www.nature.com/articles/s41380-024-02554-0 | SARS-CoV-2 infection seems to have a long-term impact on the brain, even in patients who presented mild acute disease. pNfL levels (plasma levels of neurofilament light chain) are significantly higher in long COVID patients with mild acute COVID-19 with neurocognitive symptoms when compared to HC (p = 0.0031), what could indicate the ongoing CNS damage caused by SARS-CoV-2, directly or indirectly, even in patients acutely with mild disease. | |||||||||||||||||||||
210 | Cognitive function in Mexican older adults 6-months after recovering from SARS-CoV-2 infection | 2024-04-30 | https://doi.org/10.1016/j.regg.2024.101479 | Alberto Jose Mimenza-Alvarado, | https://www.sciencedirect.com/science/article/abs/pii/S0211139X24000131 | Fifty-seven percent of patients analyzed developed CI (cognitive impairment) six months post-ICU discharge due to SARS-CoV-2, and COVID severity was the main factor associated to its outcome. | |||||||||||||||||||||
211 | Altered Brain Glucose Metabolism in COVID-19 disease: An activation likelihood estimation Meta-analysis | 2024-05-01 | https://doi.org/10.1101/2024.04.30.24306508 | Dongju Kang | https://www.medrxiv.org/content/10.1101/2024.04.30.24306508v1 | COVID-19 impacts brain glucose metabolism, typically manifesting as areas of decreased metabolism in 18F-FDG PET scans, though increases are also observed. | |||||||||||||||||||||
212 | Blood brain barrier disruption and glutamatergic excitotoxicity in post-acute sequelae of SARS COV-2 infection cognitive impairment: potential biomarkers and a window into pathogenesis | 2024-05-02 | https://doi.org/10.3389/fneur.2024.1350848 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11097901/ | Joga Chaganti | https://pubmed.ncbi.nlm.nih.gov/38756214/ | PASC with CI (cognitive impairment) is associated with BBB (blood–brain barrier) impairment, loss of WM (white matter) integrity, and inflammation at 3 months which significantly but not uniformly improved at 12 months. | ||||||||||||||||||||
213 | An FDA-approved assay platform can detect biomarkers of neuronal and glial injury in the blood of COVID-19 patients | 2024-05-03 | https://doi.org/10.1101/2024.05.02.24306477 | Alexander V. Glushakov | https://www.medrxiv.org/content/10.1101/2024.05.02.24306477v1.full-text | UCH-L1 and GFAP were significantly elevated in COVID-19 patients compared to non-COVID-19 controls. Median levels of UCH-L1 in the COVID-19 group calculated for each subject from the available time points from day 0 through day 28 were similar to levels in stroke and TBI (mild traumatic brain injury) patients. Levels of GFAP in COVID-19 positive patients were only exceeded by levels in hemorrhagic stroke patients. | |||||||||||||||||||||
214 | Tracts in the limbic system show microstructural alterations post COVID-19 recovery | 2024-05-07 | https://doi.org/10.1093/braincomms/fcae139 | Sapna S Mishra | https://academic.oup.com/braincomms/article/6/3/fcae139/7665554?login=false | Our results revealed statistically significant differences (PFWE < 0.01) in the uncinate fasciculus, cingulum cingulate, cingulum hippocampus and arcuate fasciculus in COVID survivors, suggesting the presence of microstructural abnormalities. Although there were significant differences between healthy controls and infected groups, we found no significant differences between hospitalized and non-hospitalized COVID patients. Notably, the identified tracts are part of the limbic system and orbitofrontal cortex, indicating microstructural differences in neural circuits associated with memory and emotion. | |||||||||||||||||||||
215 | Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study | 2024-05-09 | https://doi.org/10.1016/j.lanwpc.2024.101086 | Yimiao Zhao | https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(24)00080-4/fulltext#%20 | This long-term study suggests that individuals recovering from COVID-19 continue to experience cognitive complaints, psychiatric and neurological symptoms, and brain functional alteration. The rs-fMRI results indicated that the changes in brain function in regions such as the putamen, temporal lobe, and superior parietal gyrus may contribute to cognitive complaints in individuals with long COVID even after 2-year infection. | |||||||||||||||||||||
216 | Prevalence and co-occurrence of cognitive impairment in children and young people up to 12-months post infection with SARS-CoV-2 (Omicron variant) | 2024-05-10 | https://doi.org/10.1016/j.bbi.2024.05.001 | Paul Foret-Bruno | https://www.sciencedirect.com/science/article/pii/S0889159124003891 | At 12-months post-testing, 7.0 % (24/345) of first-positives and 7.5 % (27/360) of reinfected CYP (children and young people) experienced cognitive impairment. Consistently at all time points post-testing, CYP experiencing cognitive impairment were more likely to score higher on all Strengths and Difficulties Questionnaire subscales, higher on the Chalder Fatigue sub-scale for mental fatigue, lower on the Short Warwick-Edinburgh Mental Wellbeing Scale and report more trouble sleeping. | |||||||||||||||||||||
217 | Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment | 2024-05-13 | https://doi.org/10.1016/j.xcrm.2024.101561 | William T. Hu | https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00253-2 | We found that cognitive dysfunction is common; is not influenced by mood, fatigue, or sleepiness; and is correlated with MRI changes in very few people. Single-cell gene expression analysis in the cerebrospinal fluid shows findings consistent with monocyte recruitment, chemokine signaling, cellular stress, and suppressed interferon response—especially in myeloid cells. Longitudinal analysis shows slow recovery accompanied by key alterations in inflammatory genes. | |||||||||||||||||||||
218 | SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model | 2024-05-14 | https://doi.org/10.1016/j.xcrm.2024.101570 | Bina Lee | https://www.sciencedirect.com/science/article/pii/S2666379124002623?via%3Dihub | We observed that the neuroinflammatory response remains sustained even when SARS-CoV-2 is no longer detectable in the brain. This suggests that the impact of SARS-CoV-2 infection may extend beyond acute COVID-19-associated parkinsonism, as reported in recent case studies,potentially affecting those with existing PD diagnoses or those exposed to PD risk factors. Moreover, such infections could conceivably contribute to a higher incidence of PD in future years. | |||||||||||||||||||||
219 | Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity | 2024-05-16 | https://doi.org/10.1101/2024.05.16.594465 | Oana Sanislav | https://www.biorxiv.org/content/10.1101/2024.05.16.594465v1 | We show, for the first time, direct evidence of cellular uptake of viral amyloids into neuronal cells, further supporting the hypothesis that some of the neurological symptoms of COVID-19 and PASC may possess a neurotoxic amyloid aetiology. | |||||||||||||||||||||
220 | Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue | 2024-05-18 | https://doi.org/10.1038/s41467-024-48651-0 | Jonas A. Hosp | https://www.nature.com/articles/s41467-024-48651-0 | Employing magnetic resonance imaging, we conduct a comparative analysis of cerebral microstructure among patients with Post-COVID-Condition, healthy controls, and individuals that contracted COVID-19 without long-term symptoms. We reveal widespread alterations in cerebral microstructure, attributed to a shift in volume from neuronal compartments to free fluid, associated with the severity of the initial infection. | |||||||||||||||||||||
221 | Objective and subjective cognitive status after intensive care unit treatment for COVID-19 | 2024-05-21 | https://doi.org/10.1016/j.bbih.2024.100786 | https://www.ncbi.nlm.nih.gov/pmc/PMC11103414 | Kristina Struksnes Fjone | https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/38770194 | At the six-month follow-up, 23.1% (95% CI [18.2─28.5]) of the 273 respondents scored below the cut-off on the Mini-MoCA, indicating mild cognitive impairment. At the 12-month follow-up, the prevalence declined to 11.1% (95% CI [7.5─15.6]) in 253 respondents. At 12 months, almost half of the patients reported subjective cognitive complaints. Cognitive impairment declined significantly from 6 to 12 months in this cohort of COVID-19 ICU patients, while subjective cognitive complaints remained high at 12 months, perhaps attributed to a high total symptom burden. | ||||||||||||||||||||
222 | Long-COVID autonomic syndrome in working age and work ability impairment | 2024-05-23 | https://doi.org/10.1038/s41598-024-61455-y | Luca Rinaldi | https://www.nature.com/articles/s41598-024-61455-y | One in three working-age people developed a new autonomic syndrome that was still evident 6 months after the acute infection resolution. This was associated with a significant reduction in the work ability. | |||||||||||||||||||||
223 | Understanding the olfactory role in post-COVID cognitive and neuropsychiatric manifestations | 2024-05-26 | https://doi.org/10.3389/fpsyg.2024.1407887 | N Azcue | https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1407887/full | In total, 25% of the post-covid patients had a reduced smell capacity, while only 9.3% of HC presented OD (Olfactory Dysfunction). Post-COVID patients had statistically significantly worse cognitive performance and clinical status than HC. Verbal fluency (AUC = 0.85, p < 0.001), and attention (AUC = 0.82, p < 0.001) were the variables that best discriminate between groups. | |||||||||||||||||||||
224 | Post-COVID-19 Mental Health Distress in 13 Million Youth: A Retrospective Cohort Study of Electronic Health Records | 2024-05-28 | https://doi.org/10.1016/j.jaac.2024.03.023 | Yanli Zhang-James | https://www.sciencedirect.com/science/article/abs/pii/S0890856724002636 | Within two years post-SARS-CoV-2 infection, children had a probability of 0.15 in acquiring new psychiatric diagnoses, compared to 0.026 for matched non-infected children; adolescents had a 0.19 probability against 0.05 for their non-infected counterparts. The hazard ratio (HR) was 6.0 (95% confidence interval, 95%CI: 5.8-6.3) for children and 4.2 for adolescents (95%CI: 4.1-4.4). Elevated HRs were observed for almost all sub-categories of mental disorders and suicidal behaviors, with variations based on sex, severity of SARS-CoV-2 infection, and viral variants. COVID-19 was similar to other respiratory infections in increasing the rate of mental disorders in adolescents but had a significantly higher effect on children (HR 1.57, 95%CI:1.53-1.61). | |||||||||||||||||||||
225 | Beyond the acute: pain in long COVID survivors at 1.5 years | 2024-05-31 | https://doi.org/10.1007/s10072-024-07620-7 | Emel Oguz-Akarsu | https://link.springer.com/article/10.1007/s10072-024-07620-7 | A cohort of 191 individuals, initially diagnosed with mild-to-moderate COVID-19, was followed up 1.5 years later. Our study revealed that 31.9% of participants experienced at least one persistent pain symptom after 1.5 years. Headache emerged as the most prevalent symptom (29.8%), followed by myalgia (5.8%) and neuropathic pain (4.2%). | |||||||||||||||||||||
226 | Cognitive profile, neuroimaging and fluid biomarkers in post-acute COVID-19 syndrome | 2024-06-05 | https://doi.org/10.1038/s41598-024-63071-2 | Núria Guillén | https://www.nature.com/articles/s41598-024-63071-2 | Participants with confirmed SARS-CoV-2 infection and cognitive complaints ≥ 8 weeks post-acute phase were included. Forty-nine participants, with a mean time from symptom onset of 10.4 months, showed attention-executive function (69%) and verbal memory (39%) impairment. Altered attention/executive and verbal memory, common in PACS, persisted in most subjects without association with structural abnormalities, elevated cytokines, or neuronal damage markers. | |||||||||||||||||||||
227 | Cognitive deficits and cortical volume loss in COVID-19-related hyposmia | 2024-06-08 | https://doi.org/10.1111/ene.16378 | Haşim Gezegen | https://onlinelibrary.wiley.com/doi/10.1111/ene.16378 | Temporary or permanent hyposmia after COVID-19 infection leads to atrophy in the OB and olfactory-related cortical structures and subtle cognitive problems in the long term. | |||||||||||||||||||||
228 | Association of post-COVID phenotypic manifestations with new-onset psychiatric disease | 2024-06-08 | https://doi.org/10.1038/s41398-024-02967-z | Ben Coleman | https://www.nature.com/articles/s41398-024-02967-z | Our study provides evidence for association between non-psychiatric PASC-AMs (PASC-associated manifestations) and the incidence of newly diagnosed psychiatric disease. Significant associations were found for features related to multiple organ systems.There were significant associations between a diagnosis of any psychiatric disease and five categories of PASC-AMs with odds ratios highest for neurological, cardiovascular, and constitutional PASC-AMs with odds ratios of 1.31, 1.29, and 1.23 respectively. | |||||||||||||||||||||
229 | Neurocognitive Impairment in Long COVID: A Systematic Review | 2024-06-08 | https://doi.org/10.1093/arclin/acae042 | Eugenia Panagea | https://academic.oup.com/acn/advance-article/doi/10.1093/arclin/acae042/7689909?login=false | All included studies support the presence of persistent cognitive changes after COVID-19 disease. Executive function, memory, attention, and processing speed appear to be the cognitive domains that are predominantly associated with long-COVID syndrome. In this review, the high frequency of cognitive impairment after COVID-19 is evident. | |||||||||||||||||||||
230 | The impact of COVID-19 post-infection on the cognition of adults from Peru | 2024-06-10 | https://doi.org/10.3389/fpsyg.2024.1325237 | Jonathan Adrián Zegarra-Valdivia | https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1325237/abstract | This study underscores COVID-19's negative impact on cognitive function, even in mild cases, with potential heightened effects in men during acute or hyperinflammatory phases. Those with <14 days of illness (AP vs. HP) (Acute Phase vs. Hyperinflammatory Phase) had deficits in general cognitive performance (p=0.02), working memory (p=0.02), and planning (p< 0.001) | |||||||||||||||||||||
231 | Profiles of objective and subjective cognitive function in Post-COVID Syndrome, COVID-19 recovered, and COVID-19 naïve individuals | 2024-06-11 | https://doi.org/10.1038/s41598-024-62050-x | A. R. Bland | https://www.nature.com/articles/s41598-024-62050-x | We observed significant objective cognitive deficits in people who have been exposed to an acute COVID-19 infection regardless of whether they had Post-COVID Syndrome or had fully recovered, as compared to people who had never had COVID-19. This suggests that an acute infection can have long term effects on cognitive function, even without persistent COVID-19 symptoms | |||||||||||||||||||||
232 | Persistent brain metabolic impairment in long COVID patients with persistent clinical symptoms: a nine-month follow-up [18F]FDG-PET study | 2024-06-12 | https://doi.org/10.1007/s00259-024-06775-x | Tatiana Horowitz | https://link.springer.com/article/10.1007/s00259-024-06775-x | Subjects with persistent symptoms of long COVID exhibit durable deficits in brain metabolism, without progressive worsening.The anatomical ROI (region of interest) analysis confirmed the brain hypometabolism involving limbic region, the pons and cerebellum at PET1 and PET2, without significant changes between PET1 (7 months after infection) and PET2 (16 months post infection). | |||||||||||||||||||||
233 | Meta-analysis of Cognitive Function Following Non-severe SARS-CoV-2 Infection | 2024-06-12 | https://doi.org/10.1007/s11065-024-09642-6 | Tara A. Austi | https://link.springer.com/article/10.1007/s11065-024-09642-6 | Individuals with non-severe (mild/moderate) initial SARS-CoV-2 infection demonstrated worse objective cognitive performance compared to healthy comparison participants. However, those with mild (nonhospitalized) initial SARS-CoV-2 infections had better objective cognitive performance than those with moderate (hospitalized but not requiring ICU care) or severe (hospitalized with ICU care) initial SARS-CoV-2 infections. | |||||||||||||||||||||
234 | Long-Term Functional Limitations and Predictors of Recovery after COVID-19: A Multicenter Prospective Cohort Study | 2024-06-13 | https://doi.org/10.1016/j.amjmed.2024.06.005 | Marla Beauchamp | https://www.sciencedirect.com/science/article/abs/pii/S0002934324003516 | Our study provides compelling evidence of the long-term impact of COVID-19 on functional and cognitive status 1-year post-infection. At 12 months, 55.3% demonstrated clinically important deficits in mobility and 38.8% had cognitive deficits compared to premorbid levels. Fatigue was reported in 44.2%, followed by difficulty walking long distances in 35.8% and dyspnea in 33.0%. | |||||||||||||||||||||
235 | Altered brain perfusion and oxygen levels relate to sleepiness and attention in post-COVID syndrome | 2024-06-14 | https://doi.org/10.1002/acn3.52121 | Claudia Chien | https://onlinelibrary.wiley.com/doi/10.1002/acn3.52121 | Patients presented with high levels of fatigue (79%) and daytime sleepiness (45%). We found widespread decreased brain oxygen levels, most evident in the white matter (false discovery rate adjusted-p-value (p-FDR) = 0.038) and cortical grey matter (p-FDR = 0.015). | |||||||||||||||||||||
236 | Complexity and Diversity of the Neurological Spectrum of SARS-CoV-2 over Three Waves of COVID-19 | 2024-06-14 | https://doi.org/10.3390/jcm13123477 | Justyna Jachman-Kapułka | https://www.mdpi.com/2077-0383/13/12/3477 | Neurological manifestations were observed in 49%. The most common were altered mentation, headache, myalgia, mood disorder, ischemic stroke and encephalopathy. Smell and taste disturbances (STDs) were less frequent in the Omicron period. Neurological complications were predominant in the pre-Delta and Omicron periods. Ischemic stroke was observed more often in pre-Delta period. | |||||||||||||||||||||
237 | Persistent headache and chronic daily headache after COVID-19: a prospective cohort study | 2024-06-17 | https://doi.org/10.3344/kjp.24046 | Larissa Clementino Leite Sá Carvalho | https://pubmed.ncbi.nlm.nih.gov/38881283/ | Patients who had COVID-19 had a high incidence of CDH (chronic daily headache) The headache persisted beyond the acute phase of COVID-19 in 52%, and 20.3% had CDH (95% confidence interval: 13.6-28.2). The group with CDH included more females, greater impact of headache, more persistence of headache beyond the 120th day of COVID-19 and less throbbing headache than did the other individuals whose headache persisted. | |||||||||||||||||||||
238 | Neurological Manifestations of Acute SARS-CoV-2 Infection in Pediatric Patients: A 3-Year Study on Differences between Pandemic Waves | 2024-06-17 | https://doi.org/10.3390/v16060967 | Iolanda Cristina Vivisenco | https://www.mdpi.com/1999-4915/16/6/967 | Neurological manifestations were noted in 10% (n = 168) of patients with a median age of 3.2 years (interquartile range: 1–11.92). Neurological manifestations were significantly associated with the pandemic waves (p = 0.006) and age groups (p < 0.001). Seizures were noted in 4.2% of cases and reached an increasing frequency over time (p = 0.001), but were not associated with age groups. The Wuhan and Omicron waves involved the nervous system more often than the other waves. | |||||||||||||||||||||
239 | Cognitive Functioning in Patients with Neuro-PASC: The Role of Fatigue, Mood, and Hospitalization Status | 2024-06-18 | https://doi.org/10.3389/fneur.2024.1401796 | Joshua Cahan | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1401796/abstract | When adjusting for fatigue and time since onset of COVID-19 symptoms, neither objective nor subjective impairment were associated with prior hospitalization for COVID-19. Subjective cognitive concerns may persist irrespective of hospitalization status, and are likely influenced by fatigue and depression/mood symptoms. | |||||||||||||||||||||
240 | Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis | 2024-06-19 | https://doi.org/10.1038/s41398-024-02978-w | Steven Wai Ho Chau | https://www.nature.com/articles/s41398-024-02978-w | The post-COVID group has a statistically significantly higher level of fatigue compared to the control group (p < 0.001). Among the post-COVID group, the lack of any COVID vaccination before the first COVID and a higher level of material deprivation before the COVID pandemic predicts a higher load of chronic post-COVID neuropsychiatric symptoms. Partial correlation network analysis suggests that the chronic post-COVID neuropsychiatric symptoms can be clustered into two major (cognitive complaints -fatigue and anxiety-depression) and one minor (headache-dizziness) cluster. | |||||||||||||||||||||
241 | EEG signatures of cognitive decline after mild SARS-CoV-2 infection: an age-dependent study | 2024-06-20 | https://doi.org/10.1186/s12916-024-03481-1 | Yike Sun | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03481-1 | The findings underscore the enduring neurological impacts of SARS-CoV-2 infection, marked by cognitive decline and increased EEG disarray. Although children and adolescents experienced milder effects, cognitive decline and heightened low-frequency electrical activity were evident. | |||||||||||||||||||||
242 | Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications | 2024-06-21 | https://doi.org/10.1016/j.bbih.2024.100805 | Fernanda G.Q. Barros-Aragão | https://www.sciencedirect.com/science/article/pii/S2666354624000838 | Our findings put neuroinflammation as a possible driver of COVID-19 acute neurological disease in mild and severe cases. We found that COVID-19 patients presented heterogeneous neurological symptoms dissociated from lung burden. Patients presented ubiquitous systemic hyper-inflammation and broad alterations in CSF proteomics related to inflammation, innate immunity, and hemostasis, irrespective of COVID-19 severity or neuroimaging alterations. | |||||||||||||||||||||
243 | Short- and long-term neuropsychiatric outcomes in long COVID in South Korea and Japan | 2024-06-25 | https://doi.org/10.1038/s41562-024-01895-8 | Sunyoung Kim | https://www.nature.com/articles/s41562-024-01895-8 | we found that both the short- and long-term risks of developing neuropsychiatric sequelae were elevated in the discovery cohort compared with the general population and those with another respiratory infection. A range of conditions including Guillain-Barré syndrome, cognitive deficit, insomnia, anxiety disorder, encephalitis, ischaemic stroke and mood disorder exhibited a pronounced increase in long-term risk. | |||||||||||||||||||||
244 | Mental and cognitive health of COVID-19 survivors | 2024-07-02 | https://doi.org/10.3389/fpsyt.2024.1370085 | Madhushree Chakrabarty | https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1370085/abstract | COVID-19 survivors in this study had major mental health issues even one year after contracting the virus. They had significant cognitive deficits that might progress into dementia. 64.89% of COVID-19 survivors reported a deterioration in physical functioning. 44.95% reported a decline in mental health, whereas 41.49% reported a drop in cognitive performance. Detailed investigations revealed that they had an increased risk of having depression, anxiety, and poor sleep quality by 91%, 68%, and 140%, respectively. 6.1% of the patients had mild cognitive impairment, and 4% had dementia. | |||||||||||||||||||||
245 | Neuropsychiatric symptoms of patients two years after experiencing severe COVID-19: A mixed observational study | 2024-07-03 | https://doi.org/10.1016/j.medcli.2024.05.002 | José Miguel Meca-García | https://www.sciencedirect.com/science/article/pii/S0025775324003609 | High percentages of depressive, anxiety, and insomnia symptoms were detected in the second month after discharge and persisted at 12 and 24 months. The psychiatric symptoms persisted throughout the 2-year follow-up. | |||||||||||||||||||||
246 | Long COVID: cognitive, balance, and retina manifestations | 2024-07-04 | https://doi.org/10.3389/fmed.2024.1399145 | Meritxell Carmona-Cervelló | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1399145/full | A total of 166 people with LC and cognitive complaints participated. The most common self-reported symptoms were concentration and memory deficit (98.80%), brain fog (82.53%) and insomnia (71.17%). The 68.67% presented cognitive deficit in at least one domain, with executive functions being the most frequent (43.98%). The 51.52% of the participants exhibited a dysfunctional pattern in balance, and 9.2% showed some alteration in the retina. | |||||||||||||||||||||
247 | Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection | 2024-07-10 | https://doi.org/10.1038/s43587-024-00667-3 | Yu-Hui Liu | https://www.nature.com/articles/s43587-024-00667-3 | We show that the overall incidence of cognitive impairment among older COVID-19 survivors was 19.1% at 2.5 years after infection and hospitalization. | |||||||||||||||||||||
248 | New-onset chronic musculoskeletal pain following COVID-19 infection fulfil the Fibromyalgia clinical syndrome criteria | 2024-07-11 | https://doi.org/10.1101/2024.07.10.24310234 | Omar Khoja | https://www.medrxiv.org/content/10.1101/2024.07.10.24310234v1 | The average duration of symptoms from COVID-19 infection to assessment was 27.9 (SD 6.97) months. The new-onset chronic pain was widespread, primarily manifesting as muscle pain. Thirteen (72.2%) patients met the diagnostic criteria for FMS (Fibromyalgia Syndrome), with an average WPI (Widespread Pain Index) score of 8.8 and an average SS score of 8.2, indicating a high level of pain and significant adverse impact on their quality of life. | |||||||||||||||||||||
249 | Brain Effects of Mild COVID-19 in Healthy Young Adults: A Pilot Study | 2024-07-18 | https://doi.org/10.1016/j.heliyon.2024.e34764 | Michael L. Lipton | https://www.sciencedirect.com/science/article/pii/S2405844024107955 | Our pilot data suggests that mild COVID-19 may result in brain pathology and impact neurocognitive function in younger adults in a manner parallel to prior findings in older individuals. We identified a decrease of intracellular volume fraction (ICVF), decrease of isotropic volume fraction (ISO) and decrease of orientation dispersion index (ODI) in multiple inferior frontal regions of interest in COVID-19 patients; this longitudinal change was significantly different from the control group which demonstrated increases in equivalent measures. This pattern suggests injury with neuronal loss and/or inflammation as underlying mechanisms. | |||||||||||||||||||||
250 | Cerebral microbleeds in patients with COVID-19: is there an inevitable connection? | 2024-07-19 | https://doi.org/10.1093/braincomms/fcae236 | Yuchang Wang | https://academic.oup.com/braincomms/article/6/5/fcae236/7717184?login=false | Our findings reveal a pronounced correlation between cerebral microbleeds and increased severity of COVID-19, emphasizing the role of direct viral effects, inflammatory responses and coagulation disturbances. CMBs associated with SARS-CoV-2 are more than mere coincidences; they exhibit a significant correlation with the infection. Emerging imaging evidence indicates that CMBs, particularly in the proximal cortical regions and corpus callosum, commonly occur alongside white matter pathology and are often accompanied by cognitive impairments in COVID-19 patients. | |||||||||||||||||||||
251 | Brains Under Stress: Unravelling the Effects of the COVID-19 Pandemic on Brain Ageing | 2024-07-22 | https://doi.org/10.1101/2024.07.22.24310790 | Ali-Reza Mohammadi-Nejad | https://www.medrxiv.org/content/10.1101/2024.07.22.24310790v1 | The “Pandemic” group showed on average 11-month higher deviation of predicted brain age vs. chronological age (brain age gap) at the second time point compared with controls. These deviations existed regardless of SARS-CoV-2 infection. However, accelerated brain ageing correlated with reduced cognitive performance only in COVID-infected participants. | |||||||||||||||||||||
252 | Effects of post-acute COVID-19 syndrome on cerebral white matter and emotional health among non-hospitalized individuals | 2024-07-22 | https://doi.org/10.3389/fneur.2024.1432450 | Nathan Churchill | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1432450/abstract | These results provide preliminary evidence that indices of white matter microstructure distinguish PACS from symptomatic non-COVID infection. Despite similar symptoms, the COVID-19 group had reduced mean and axial diffusivity, along with increased mean kurtosis and neurite dispersion, in deep white matter. After adjusting for social satisfaction, higher levels of negative affect in the COVID-19 group were also correlated with increased mean kurtosis and reduced free water in white matter. | |||||||||||||||||||||
253 | Internal tremors and vibrations in long COVID: a cross-sectional study | 2024-07-26 | https://doi.org/10.1016/j.amjmed.2024.07.008 | Tianna Zhou | https://www.sciencedirect.com/science/article/pii/S0002934324004704 | Among study participants with long COVID, 158 (37%) reported “internal tremors, or buzzing/vibration” as a long COVID symptom. The 2 groups reported similar pre-pandemic comorbidities, but people with internal tremors reported worse health as measured by the Euro-QoL visual analogue scale and had higher rates of new-onset mast cell disorders and neurologic conditions. | |||||||||||||||||||||
254 | Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK | 2024-07-31 | https://doi.org/10.1016/S2215-0366(24)00214-1 | Maxime Taquet | https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(24)00214-1/fulltext | Psychiatric and cognitive symptoms appear to increase over the first 2–3 years post-hospitalisation due to both worsening of symptoms already present at 6 months and emergence of new symptoms. Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Almost one in two respondents in this study experienced moderate to severe depression, one in four reported severe cognitive decline, and one in nine had objective signs of severe cognitive deficits (which would equate to a difference of 30 points on a typical IQ scale). | |||||||||||||||||||||
255 | Evaluation of microstructural brain changes in post-coronavirus disease 2019 (COVID-19) patients with neurological symptoms: a cross-sectional study | 2024-08-01 | https://doi.org/10.21037/qims-24-162 | Ibrahim Ibrahim | https://qims.amegroups.org/article/view/126402/html | Post-COVID-19 patients exhibit increased MD (mean diffusivity) in the forceps minor and body of the CC (corpus callosum). Furthermore, hyperintense lesions were identified in subcortical and deep white matter areas in the vast majority of symptomatic patients. This finding suggests a potential association between microstructural brain changes in post-COVID-19 patients and reported neurological symptoms, with significant implications for research and clinical applications. | |||||||||||||||||||||
256 | Effects of post-acute COVID-19 syndrome on cerebral white matter and emotional health among non-hospitalized individuals | 2024-08-05 | https://doi.org/10.3389/fneur.2024.1432450 | Nathan W. Churchill | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1432450/full | These results provide preliminary evidence that indices of white matter microstructure distinguish PACS from symptomatic non-COVID infection. Moreover, white matter effects seen in PACS correlate with the severity of emotional sequelae, providing novel insights into this highly prevalent disorder. The COVID-19 group had reduced mean and axial diffusivity, along with increased mean kurtosis and neurite dispersion, in deep white matter. | |||||||||||||||||||||
257 | Reduced risk tolerance and cortical excitability following COVID-19 infection | 2024-08-06 | https://doi.org/10.1111/cns.14879 | Yujing Wang | https://onlinelibrary.wiley.com/doi/10.1111/cns.14879 | We found that the risk tolerance of people with a history of COVID-19 infection has increased, indicating that they may be more likely to make risk decisions than healthy people, especially when faced with known risks. | |||||||||||||||||||||
258 | Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment | 2024-08-07 | https://doi.org/10.3389/fnins.2024.1435218 | Serena Fineschi | https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1435218/abstract | Post-COVID patients had higher levels of physical fatigue, mental fatigue, depression and anxiety than controls, and showed cognitive impairment in all RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) domains except in Visuospatial/Construction. We observed a significant positive correlation between RBANS total scale index score and grey matter volume in right superior/middle temporal gyrus (p<0.05 ), and a significant negative correlation between white matter integrity and post-COVID symptoms (p<0.05) in the same area. | |||||||||||||||||||||
259 | Evolving trends in neuropsychological profiles of post COVID-19 condition: A 1-year follow-up in individuals with cognitive complaints | 2024-08-08 | https://doi.org/10.1371/journal.pone.0302415 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc11309414/ | Nicholas Grunden | https://pubmed.ncbi.nlm.nih.gov/39116061/ | Our findings indicate that cognitive difficulties persist both at test score and cognitive domain levels in many cases of post COVID-19 condition, but evidence suggests some improvement in global measures of attention, executive functioning and overall self-rated health. Furthermore, an effect of hospitalization on cognitive symptoms post COVID-19 may be more discernible over time. | ||||||||||||||||||||
260 | The risk of cognitive decline and dementia in older adults diagnosed with COVID-19: A systematic review and meta-analysis | 2024-08-08 | https://doi.org/10.1016/j.arr.2024.102448 | 39127446 | A Shrestha | https://pubmed.ncbi.nlm.nih.gov/39127446/ | The overall mean Montreal Cognitive Assessment (MoCA) score in COVID-19 patients was 23.34 out of 30. indicating cognitive impairment. The overall proportion of patients identified as having new onset cognitive impairment was 65%. Subgroup analyses indicated that time since infection significantly improves overall MoCA score and reduces proportion of patients with cognitive impairment. | ||||||||||||||||||||
261 | Hospitalized children with COVID-19 infection during large outbreak of SARS-CoV-2 Omicron strain: a retrospective study in Chaozhou, Guangdong, China | 2024-08-10 | https://doi.org/10.1080/07853890.2024.2389301 | Fen Lin | https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2389301#abstract | MIS-C and abnormal neuroimaging appear to be relatively common phenomena in severe/critical cases. Among the (22) severe/critical patients, eight developed multisystem inflammatory syndrome in children (MIS-C), and tragically, one patient’s condition worsened and resulted in death. Furthermore, MRI scans revealed abnormal brain signals in six severe/critical patients. The severe/critical group also exhibited more pronounced laboratory abnormalities, including decreased haemoglobin and elevated ALT, AST, LDH and CK levels. | |||||||||||||||||||||
262 | A Disease Hidden in Plain Sight: Pathways and Mechanisms of Neurological Complications of Post-acute Sequelae of COVID-19 (NC-PASC) | 2024-08-12 | https://doi.org/10.1007/s12035-024-04421-z | 39133434 | Apoorva Saxena | https://pubmed.ncbi.nlm.nih.gov/39133434/ | More than one-third of individuals with a prior SARS-CoV-2 infection show involvement of both the central nervous system (CNS) and peripheral nervous system (PNS), as evidenced by an approximately threefold higher incidence of neurological symptoms in observational studies. | ||||||||||||||||||||
263 | Neurologic manifestations of Long COVID in Colombia: a comparative analysis of post-hospitalization vs. non-hospitalized patients | 2024-08-12 | https://doi.org/10.3389/fnhum.2024.1450110 | Carolina Hurtado | https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2024.1450110/full | Our findings highlight the high incidence and heterogeneity of the neurologic symptoms and impacts of Long COVID even more than 2 years from disease onset. Compared to NNP (non-hospitalized Neuro-PASC), PNP (post-hospitalization Neuro-PASC) patients showed a higher frequency of abnormal neurological exam findings (64% vs. 42%, p = 0.028). Both groups had impaired quality of life (QoL) in domains of cognition, fatigue, anxiety depression and sleep disturbance, and performed worse on processing speed and attention than a normative population. In addition, NNP patients performed worse on executive function than PNP patients (T-score 42.6 vs. 48.5, p = 0.012). PASC symptoms of anxiety and depression were associated with worse QoL and cognitive outcomes. | |||||||||||||||||||||
264 | Characterization of change in cognition before and after COVID-19 infection in essential workers at midlife | 2024-08-13 | https://doi.org/10.1016/j.ajmo.2024.100076 | Zennur Sekendiz | https://www.sciencedirect.com/science/article/pii/S266703642400013X | Findings from this longitudinal causal modeling study revealed that COVID-19 and PASC appeared to accelerate cognitive deterioration, especially in executive function. Longitudinal models indicated a significant decline in cognitive throughput (β=-0.168, P=.001) following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors. Observed changes in throughput were equivalent to 10.6 years of normal aging. COVID-19 was associated with observed cognitive decline and was worse among patients with PASC or severe COVID-19. | |||||||||||||||||||||
265 | Mental health problems raise the odds of cognitive impairment in COVID-19 survivors | 2024-08-13 | https://doi.org/10.3389/fpsyt.2024.1370085 | Madhushree Chakrabarty | https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1370085/full | Compared to the matched controls, COVID-19 patients had greater depression (p<.001), anxiety (p<.001), stress (p =.003), and insomnia (p <.001). They also scored significantly lower on Addenbrooke’s Cognitive Examination-III (p =.009) and Picture Naming Test (p =.005) and took significantly longer to complete Trail Making Test-A (p =.002). | |||||||||||||||||||||
266 | The Impact of COVID-19 on Neuropsychological and Emotional-Behavioural Development in a Group of 8- and 9-Year-Old Children | 2024-08-14 | https://doi.org/10.3390/jcm13164768 | Angelica Marfoli | https://www.mdpi.com/2077-0383/13/16/4768 | SARS-CoV-2 infection negatively affected the emotional development of children contracting the virus. The Wilcoxon signed-rank test revealed a significant change in mood after the COVID-19 period only in the CG (children who contracted) participants (p = 0.019). Our results indicated a significant decrease in mood in children who tested positive for SARS-CoV-2, while no pre–post differences in children who did not experience infection were found. | |||||||||||||||||||||
267 | Neural basis of fatigue in post-COVID syndrome and relationships with cognitive complaints and cognition | 2024-08-14 | https://doi.org/10.1016/j.psychres.2024.116113 | Maria Diez-Cirarda | https://www.sciencedirect.com/science/article/pii/S0165178124003986 | Findings confirm that fatigue in post-COVID syndrome is related to cerebral connectivity patterns, evidencing its brain substrates. Fatigue was present in 86 % of patients, and was highly correlated to subjective cognitive complaints. Fatigue was associated with structural and functional connectivity mostly in frontal areas but also temporal, and cerebellar areas, showing mental fatigue different pattern of functional connectivity correlates compared to physical fatigue. | |||||||||||||||||||||
268 | Clinical characteristics, treatment and prognosis of children with SARS-CoV-2 infection complicated with severe neurological dysfunctions in Foshan, China | 2024-08-15 | https://doi.org/10.3389/fped.2024.1414023 | Xiaoqian Chen | https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1414023/full | SARS-CoV-2 infection in children can lead to severe neurological damage. High fever, convulsions, and inflammatory factors serve as early warning indicators. | |||||||||||||||||||||
269 | Autonomic Imbalance and Elevated Inflammatory Cytokines in Long COVID: A Cross-Sectional Study | 2024-08-15 | https://doi.org/10.7759/cureus.66971 | Lakshmi Jatiya | https://pubmed.ncbi.nlm.nih.gov/39280382/ | Out of 150 subjects 36 were found to have autonomic dysfunction graded according to Ewing's criteria. Individuals with autonomic dysfunction also had significantly increased inflammatory biomarker levels. There was also significant correlation between inflammatory markers and autonomic function test and heart rate variability parameters. | |||||||||||||||||||||
270 | Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection: A Longitudinal Study | 2024-08-16 | https://doi.org/10.3390/neurolint16040064 | Marta Almeria | https://pubmed.ncbi.nlm.nih.gov/39195566/ | Persistent symptoms are common regardless of disease severity and are often linked to cognitive complaints. Six months after COVID-19, the most frequently reported symptoms included headache, dyspnea, fatigue, cognitive complaints, anxiety, and depression. Overall, neuropsychological and psychopathological improvement was observed at 6 months regardless of disease severity and cognitive complaints. | |||||||||||||||||||||
271 | Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations | 2024-08-17 | https://doi.org/10.1038/s41598-024-69772-y | Leonie Kausel | https://www.nature.com/articles/s41598-024-69772-y | Patients who presented with anosmia exhibited more impulsive alternative changes after a shift in probabilities (r = − 0.26, p = 0.001), while patients who required hospitalization showed more perseverative choices (r = 0.25, p = 0.003). Anosmia correlated with brain measures, including decreased functional activity during the decision-making task, thinning of cortical thickness in parietal regions, and loss of white matter integrity. | |||||||||||||||||||||
272 | Persistent Autonomic and Immunologic Abnormalities in Neurologic Post-Acute Sequelae of SARS-CoV2 Infection | 2024-08-22 | https://doi.org/10.1212/WNL.0000000000209742 | David S. Goldstein | https://www.neurology.org/doi/10.1212/WNL.0000000000209742 | In Neuro-PASC most of the autonomic and immunologic abnormalities found initially are still present after more than a year. 71% of initially abnormal test results remained abnormal at follow-up, including the pattern of CSF (cerenral spinal fluid) and serum oligoclonal bands, CSF indices of central catecholamine deficiency, baroreflex-cardiovagal dysfunction, the occurrence of tilt-evoked sudden hypotension, white matter hyperintensities on MRI, and adaptive responses in CSF. | |||||||||||||||||||||
273 | Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study | 2024-08-23 | https://doi.org/10.1177/0271678X241277621 | Yao Wang | https://journals.sagepub.com/doi/10.1177/0271678X241277621 | Our study suggested that lower CBF (cerebral blood flow) is associated with persistent clinical symptoms in long COVID individuals, possibly as a consequence of the complex interactions among multiple COVID-19-related genes. Lower CBF in the left frontal-temporal gyrus was associated with higher fatigue and worse cognition in individuals with long COVID. This CBF pattern was spatially associated with the expression of 2,178 genes, which were enriched in the molecular functions and biological pathways of COVID-19. | |||||||||||||||||||||
274 | Prevalence and Risk Factors of Headache Associated with COVID-19 | 2024-08-24 | https://doi.org/10.3390/jcm13175013 | Oľga Duraníková | https://pubmed.ncbi.nlm.nih.gov/39274228/ | One-third of hospitalized patients experienced headaches, predominantly younger individuals (p < 0.001) and women (p = 0.002). Remarkably, 50% of patients reported persistent headaches 12-15 months post-infection. Persistent headaches were unilateral (40%) and pulsating (38%) with phonophobia (74%). | |||||||||||||||||||||
275 | Exploring Neurocognitive and Emotional Outcomes of Long COVID: A Study Among Pakistani Patients | 2024-08-26 | https://doi.org/10.7759/cureus.67815 | Muddsar Hameed | https://pubmed.ncbi.nlm.nih.gov/39323692/ | Our findings highlight the extensive impact of long-term COVID-19 on neurocognitive and emotional health, with significant gender differences observed in emotional outcomes. COVID-19 symptoms showed a negative correlation with MMSE scores (Mini-Mental State Examination) and positive correlations with ADHD, depression, and anxiety. | |||||||||||||||||||||
276 | Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia | 2024-08-29 | https://doi.org/10.1002/alz.14089 | Yang Jiang | https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14089 | Some individuals with COVID-19 display abnormal intrinsic brain activity and cognitive impairments that resemble those seen in neurodegenerative diseases, particularly ADRD (Alzheimer's disease and related dementia). The evidence presented indicates that COVID-19 and ADRD pathologies share common impacts on synaptic and neurovascular dysfunctions involving astrocyte reactivity and neuroinflammation. | |||||||||||||||||||||
277 | Long-term brain fog and cognitive impairment in previously hospitalized COVID-19 patients | 2024-08-29 | https://doi.org/10.1371/journal.pone.0309102 | Barbara Junco | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0309102 | COVID-19 level of severity was associated with greater number of endorsed brain fog symptoms, worse overall cognitive functioning and reduced performance on an attention and working memory task at 2-year follow-up. Brain fog symptoms most associated with COVID-19 severity included difficulty focusing, detached and feeling sleepy. Patients’ cognitive performance was generally below average. | |||||||||||||||||||||
278 | Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A Mendelian randomization study | 2024-08-30 | https://doi.org/10.1016/j.heliyon.2024.e37193 | Zirui Wang | https://www.sciencedirect.com/science/article/pii/S2405844024132240 | Our finding demonstrated that COVID-19 had a long-term impact on the subcortical structures and led to the reduction of their volumes, especially caudate. Our MR analyses indicated that genetically liability to COVID‐19 susceptibility was negatively associated with longitudinal volumetric change of caudate (surpassing Bonferroni correction) and pallidum. Furthermore, COVID‐19 hospitalization and severity were negatively associated with longitudinal volumetric changes of caudate and thalamus. | |||||||||||||||||||||
279 | Long COVID patients’ brain activation is suppressed during walking and severer symptoms lead to stronger suppression | 2024-08-30 | https://doi.org/10.1007/s00406-024-01870-4 | Gengbin Chen | https://link.springer.com/article/10.1007/s00406-024-01870-4 | Individuals with Long COVID exhibited decreased activation in brain regions associated with cognitive and motor function compared to SARS-CoV-2 uninfected individuals. Moreover, those with more severe initial symptoms or functional impairment displayed heightened inhibition in these brain regions. | |||||||||||||||||||||
280 | Post-acute sequelae of COVID infection and cerebral venous outflow disorders: Overlapping symptoms and mechanisms? | 2024-09-02 | https://doi.org/10.1177/15910199241273946 | Thomas Mandel Clausen | https://journals.sagepub.com/doi/10.1177/15910199241273946 | CVD (cerebral venous outflow disorders) workup in a series of 6 patients with neurological long COVID symptoms showed jugular vein stenosis by CT venography and varying degrees of increased intracranial pressure. | |||||||||||||||||||||
281 | How Mild Is the Mild Long COVID? A Comprehensive Neuropsychological Assessment of Patients with Cognitive Complaints | 2024-09-07 | https://doi.org/10.1093/arclin/acae071 | Lucas Emmanuel Lopes-Santos | https://academic.oup.com/acn/advance-article-abstract/doi/10.1093/arclin/acae071/7750687?redirectedFrom=fulltext&login=false | Participants from the mild COVID group reported cognitive symptoms persisting for an average of 203.86 days and presented a higher frequency of psychological treatment history (81.8%) compared with the control group (25.0%). Significant reductions in verbal working memory were observed in the mild COVID group. Our findings underscore the persistence of these deficits even in non-hospitalized cases, suggesting potential inflammatory mechanisms in the central nervous system. | |||||||||||||||||||||
282 | Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome | 2024-09-09 | https://doi.org/10.1038/s41598-024-71475-3 | Elisa Gentilotti | https://www.nature.com/articles/s41598-024-71475-3 | NSc-PCS (neurosensorial cluster of post-COVID-19 syndrome) has a complex, fluctuating, multifaceted presentation. Out of 1187 patients (female, N = 630), 550 (47%) presented NSc-PCS. Out of the 50 patients evaluated with psychophysical tests, 66% showed smell reduction with a qualitative alteration in 50% of hyposmic and 35% of normosmic patients. Hypogeusia was present in 14 (28%) of the patients assessed, with 56% showing a qualitative alteration; 53% of normogeusic patients presented qualitative disorders. | |||||||||||||||||||||
283 | Psychiatric morbidity among SARS and COVID-19 survivors at 30 months post-infection | 2024-09-10 | https://doi.org/10.12809/eaap2431 | Mimi MC Wong | https://www.easap.asia/index.php/component/k2/item/977-2024-v34n4-p103 | Compared with SARS survivors, COVID-19 survivors had a lower prevalence of psychiatric disorder at 30 months post-infection (6.7% vs 33.3%, p <0.001). Higher levels of anxiety and depression were independently associated with greater perceived functional impairment, higher average pain intensity level in the past month, and less use of rational problem solving. | |||||||||||||||||||||
284 | Multimodal neuroimaging in Long-COVID and its correlates with cognition 1.8 years after SARS-CoV-2 infection: a cross-sectional study of the Aliança ProHEpiC-19 Cognitiu | 2024-09-12 | https://doi.org/10.3389/fneur.2024.1426881 | Rosalia Dacosta-Aguayo | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1426881/full | People with LC exhibit cognitive impairments linked to long-lasting changes in brain structure and function. According to the Frascati criteria, more than half of the participants had deficits in the executive (59%) and attentional (55%) domains, while 40% had impairments in the memory domain. | |||||||||||||||||||||
285 | Neurological long-COVID: Associations among fatigue, dysautonomia, depression, and subjective memory complaints | 2024-09-13 | https://doi.org/10.1016/j.clineuro.2024.108522 | Giovanni Furlanis | https://www.sciencedirect.com/science/article/abs/pii/S0303846724004098 | This study showed associations between fatigue, dysautonomia and depression, as well as with symptom burden in acute and long-COVID. Predictors of fatigue in long-COVID included symptom burden during acute infection and long-COVID, as well as high scores in COMPASS and BDI questionnaires. | |||||||||||||||||||||
286 | Executive deficits after SARS-CoV-2 infection: A cross-sectional population study | 2024-09-13 | https://doi.org/10.1016/j.bbih.2024.100857 | S. Buer | https://www.sciencedirect.com/science/article/pii/S2666354624001352 | Our study confirms more perceived executive deficits following SARS-CoV-2 infection compared to non-infected controls, with metacognitive aspects being the most affected. Specifically, the SARS-CoV-2 positive status group indicated significantly more deficits related to metacognition, with the greatest difference demonstrated for working memory. This difference remained when adjusting for various demographic factors and comorbidities, with significantly greater odds of reporting above the clinical threshold following SARS-CoV-2 infection, as observed on the global executive composite score 6–12 months after infection (OR 1.97). | |||||||||||||||||||||
287 | A Gene Cluster of Mitochondrial Complexes Contributes to the Cognitive Decline of COVID-19 Infection | 2024-09-14 | https://doi.org/10.1007/s12035-024-04471-3 | Wen-tao Xu | https://link.springer.com/article/10.1007/s12035-024-04471-3 | We observed an upregulation in the expression of genes linked to the inflammatory response and oxidative stress, whereas genes associated with cognitive function were downregulated in the brains of patients infected with COVID-19. Through single-nucleus RNA sequencing (snRNA-seq) analysis, we found that COVID-19 infection triggers the immune responses in microglia and astrocytes and exacerbates oxidative stress in oligodendrocytes, oligodendrocyte progenitors (OPCs), and neurons. | |||||||||||||||||||||
288 | Acute COVID-19 severity markers predict post-COVID new-onset psychiatric disorders: A 2-year cohort study of 34,489 patients | 2024-09-16 | https://doi.org/10.1038/s41380-024-02739-7 | Matthieu Gasnier | https://www.nature.com/articles/s41380-024-02739-7 | Hospital stay >7 days, acute delirium, and elevated monocyte count during acute COVID-19 predict post-COVID new-onset psychiatric disorders. 10.8% had at least one post-COVID new-onset psychiatric disorder. | |||||||||||||||||||||
289 | Cardiovascular and kidney diseases are positively associated with neuroinflammation and reduced Brain-Derived Neurotrophic Factor in patients with severe COVID-19 | 2024-09-19 | https://doi.org/10.1016/j.bbih.2024.100855 | Rafael R. Ferreira | https://www.sciencedirect.com/science/article/pii/S2666354624001339 | Although SARS-CoV-2 neuroinvasiveness appears to be lower compared to the respiratory tract, our results corroborate the hypothesis that it is sufficient to induce a pro-inflammatory state that could further impair neural homeostasis and induce brain abnormalities found in COVID-19 patients. | |||||||||||||||||||||
290 | Changes in the epidemiology of pediatric brain abscesses pre- and post-COVID-19 pandemic: a single-center study | 2024-09-21 | https://doi.org/10.1186/s12887-024-05082-6 | Yuchen Liu | https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-024-05082-6 | The post-COVID-19 cohort had an average of 5.5 cases/year, which is a 129.2% increase compared to the pre-COVID-19 cohort's average of 2.4 cases/year. A potential rise in the rate of intensive care unit admission was observed (36.36% vs 8.33%, p = 0.113). There was a significant increase in the number of brain abscess patients after the COVID-19 pandemic. | |||||||||||||||||||||
291 | SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion | 2024-09-21 | https://doi.org/10.1101/2022.09.15.508120 | Wanda Christ | https://www.biorxiv.org/content/10.1101/2022.09.15.508120v2 | We show that the incubation of HSV-1 and SARS-CoV-2 with human cerebrospinal fluid (CSF) leads to the amyloid aggregation of several proteins known to be involved in neurodegenerative diseases. Our results show that viruses can physically induce amyloid aggregation of proteins in human CSF and result in soluble protein depletion, and thus providing a potential mechanism that may account for the association between persistent and latent/reactivating brain infections and neurodegenerative diseases. | |||||||||||||||||||||
292 | Changes in memory and cognition during the SARS-CoV-2 human challenge study | 2024-09-21 | https://doi.org/10.1016/j.eclinm.2024.102842 | William Trender | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00421-8/fulltext | Mild Wildtype SARS-CoV-2 infection can be followed by small changes in cognition and memory that persist for at least a year. Infected volunteers showed statistically lower baseline-corrected global composite cognitive scores than uninfected volunteers, both acutely and during follow up. Memory and executive function tasks showed the largest between-group differences. | |||||||||||||||||||||
293 | Differences in Brain Structure and Cognitive Performance Between Patients with Long-COVID and those with Normal Recovery | 2024-09-22 | https://doi.org/10.1016/j.neuroimage.2024.120859 | Breanna K Nelson | https://pubmed.ncbi.nlm.nih.gov/39317274/ | The long-COVID group had significantly (p<0.05) lower mean diffusivity than the normal recovery group across multiple white matter regions, including the internal capsule, anterior and superior corona radiata, corpus callosum, superior fronto-occiptal fasciculus, and posterior thalamic radiation. However, the effect sizes of these differences were small (all β<|0.3|) and no significant differences were found for the other DTI (diffusion tensor imaging) metrics. | |||||||||||||||||||||
294 | Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction | 2024-09-23 | https://doi.org/10.1038/s41591-024-03309-8 | Greta K. Wood | https://www.nature.com/articles/s41591-024-03309-8 | Cognitive deficits were global and associated with elevated brain injury markers, and reduced anterior cingulate cortex volume one year after COVID-19. The severity of the initial infective insult, post-acute psychiatric symptoms, and a history of encephalopathy were associated with greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. | |||||||||||||||||||||
295 | Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets | 2024-09-23 | https://doi.org/10.1101/2024.09.21.614276 | Feline F. W. Benavides | https://www.biorxiv.org/content/10.1101/2024.09.21.614276v1 | We observed an increased number of Alzheimer type II astrocytes in the hindbrains of SARS-CoV-2 inoculated ferrets. Additionally, we detected an increased microglial activation in the olfactory bulb and hippocampus, and a decrease in the astrocytic activation status in the white matter and hippocampus of SARS-CoV-2 inoculated ferrets. In conclusion, although showed that SARS-CoV-2 has limited neuroinvasive potential in this model for subclinical to mild respiratory disease, there is evidence for neurovirulent potential. | |||||||||||||||||||||
296 | Impact on the nervous system of long COVID-19 infection in children | 2024-09-24 | 10.1055/s-0044-1789224 | Nora Granana | https://www.thieme-connect.de/products/ejournals/html/10.1055/s-0044-1789224#info | Neurological symptoms were assessed between 6 to 12 months and 2 years after the infection. Acute symptoms, including headache, anosmia, ageusia, and myalgia, were observed in more than 20% of the children, but they generally resolved within 6 to 12 months. Persistent functional difficulties, such as in studying, paying attention, and socializing, were reported in 3% of the cases. | |||||||||||||||||||||
297 | Self-reported immune status and COVID-19 associated subjective cognitive functioning in post-COVID-19 syndrome: Examination of an Irish cohort | 2024-09-24 | https://doi.org/10.1002/brb3.70027 | Jessica Holland | https://onlinelibrary.wiley.com/doi/10.1002/brb3.70027 | Significant differences were observed between groups in terms of perceived immune status, perceived cognitive function, depression scores, and fatigue, with the “PCS” (post-COVID-19 syndrome) group reporting lower immune status, more cognitive difficulties, and higher levels of depression and fatigue. Regression analysis in the PCS group indicated that immune status and depression significantly contributed to variance in subjective cognitive functioning, with immune status remaining a significant predictor of cognitive functioning scores | |||||||||||||||||||||
298 | A Mixed Methods Analysis of Long COVID Symptoms in Black Americans: Examining Physical and Mental Health Outcomes | 2024-09-24 | https://doi.org/10.1007/s40615-024-02170-2 | Janelle R. Goodwill | https://link.springer.com/article/10.1007/s40615-024-02170-2 | Black adults with long COVID experienced worse outcomes across all mental health measures. Quantitative results, however, showed that Black adults living with long COVID reported significantly more anxiety, depressive symptoms, and hopelessness. Persons with long COVID were also significantly more likely to report experiencing psychosis, suicidal ideation, suicide plans, and suicide attempts within the last year. | |||||||||||||||||||||
299 | Altered functional brain connectivity, efficiency, and information flow associated with brain fog after mild to moderate COVID-19 infection | 2024-09-27 | https://doi.org/10.1038/s41598-024-73311-0 | Shelli R. Kesler | https://www.nature.com/articles/s41598-024-73311-0 | The COVID-19 group demonstrated significantly lower cognitive function (W = 475, p < 0.001, effect size r = 0.58) and lower functional connectivity in multiple brain regions (mean t = 3.47 ±0.36, p = 0.03, corrected, effect size d = 0.92 to 1.5). Hypo-connectivity of these regions was inversely correlated with subjective cognitive function and directly correlated with fatigue (p < 0.05, corrected). | |||||||||||||||||||||
300 | Neuroimaging evaluations of olfactory, gustatory, and neurological deficits in patients with long-term sequelae of COVID-19 | 2024-09-28 | https://doi.org/10.1007/s11682-024-00936-0 | Carla Masala | https://link.springer.com/article/10.1007/s11682-024-00936-0 | Our data showed that patients with long COVID symptoms exhibited a significant decrease in odor threshold, odor discrimination, odor identification, and their sum TDI score compared to age-matched healthy controls. In addition, our results indicated significant correlations between odor discrimination and the increased activation in the right hemisphere, in the frontal pole, and in the superior frontal gyrus. | |||||||||||||||||||||
301 | Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19 | 2024-09-29 | https://doi.org/10.1111/acel.14352 | Xuetao Qi | https://onlinelibrary.wiley.com/doi/10.1111/acel.14352 | we found abnormal accumulation of hyperphosphorylated tau protein in the hippocampus and medial entorhinal cortex within 4–13 months post clinically recovery from acute COVID-19, together with prolonged activation of glia cells and increases in inflammatory factors, even though no SARS-COV-2 invasion was detected in these regions. These results provide neuropathological evidences linking COVID-19 with prognostic increase of risk for AD. | |||||||||||||||||||||
302 | Acute onset psychiatric diseases after SARS-CoV-2 virus infection among pediatric patients | 2024-09-29 | 10.3389/fneur.2024.1445903 | Lu Yang | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1445903/abstract | New-onset psychiatric symptoms directly related to SARS-CoV-2 virus infection are not rare phenomena among pediatric patients. We reported eleven new cases of psychiatric disease directly related to SARS-CoV-2 virus infection and reviewed twelve previously reported cases among children and adolescents. They had various psychiatric symptoms within three weeks after the virus infection. | |||||||||||||||||||||
303 | Neuroimaging Correlates of Post-COVID-19 Symptoms: A Functional MRI Approach | 2024-09-29 | https://doi.org/10.3390/diagnostics14192180 | Marine M. Tanashyan | https://www.mdpi.com/2075-4418/14/19/2180# | Post-COVID fatigue syndrome associated with subjective cognitive impairment could show changes in brain functional activity in the areas connected with information processing speed and quality. Cognitive task fMRI analysis showed significantly higher activation in the post-COVID group versus healthy volunteers’ group. Between-group analysis showed significant activation differences. | |||||||||||||||||||||
304 | Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection | 2024-09-30 | https://doi.org/10.1038/s41598-024-72421-z | A. Nuber-Champier | https://www.nature.com/articles/s41598-024-72421-z | IL-1β levels were associated with verbal episodic memory total recall scores 6–9 months post-infection. At 12–15 months post-infection IL-6 predicted verbal episodic memory score. This study demonstrated that the severity of inflammatory reaction at acute phase of SARS-CoV-2 infection predicts verbal episodic memory performance in the long-term post-infection. | |||||||||||||||||||||
305 | Oneyear longitudinal study on biomarkers of blood–brain barrier permeability in COVID-19 patients | 2024-09-30 | https://doi.org/10.1038/s41598-024-73321-y | Johanna Wallensten | https://www.nature.com/articles/s41598-024-73321-y | COVID-19 is associated with transient increased BBB permeability, shown by elevated levels of astrocyte biomarkers in plasma. Peak levels of both biomarkers were observed at 4 months in the subset of 55 patients who were measured at this timepoint. At 12 months, the biomarkers had returned to baseline levels. | |||||||||||||||||||||
306 | The neuropsychological impacts of COVID-19 in non-hospitalized patients with long COVID and brain fog | 2024-10-01 | 10.1097/JCMA.0000000000001175 | Chuang, Yu-Chen | https://journals.lww.com/jcma/abstract/9900/the_neuropsychological_impacts_of_covid_19_in.454.aspx | Nearly 70% of patients with subjective cognitive complaints and long COVID had objective cognitive impairments. The processing speed (27.3%), memory recall (21.8%), memory learning (20.0%), and inhibitory control (18.2%) were the most affected areas. Self-reported anxiety and depression were observed in 35% and 33% of patients, respectively. | |||||||||||||||||||||
307 | Lexical retrieval difficulties in post-COVID-19 syndrome: Insights from verbal fluency and naming tasks | 2024-10-01 | https://doi.org/10.1111/1460-6984.13118 | María González-Nosti | https://onlinelibrary.wiley.com/doi/10.1111/1460-6984.13118 | These findings reveal significant word retrieval difficulties in PCS patients, suggesting that cognitive impairment related to language may be more pronounced than previously understood. PCS patients demonstrated significantly poorer performance compared with controls across all verbal fluency tasks. Notably, younger patients performed worse than older, a paradoxical trend also observed in previous research. | |||||||||||||||||||||
308 | COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study | 2024-10-02 | https://doi.org/10.1038/s41398-024-03108-2 | Azzurra Invernizzi | https://www.nature.com/articles/s41398-024-03108-2 | Our results show persistent structural, functional and cognitive brain changes in key brain areas associated with olfaction and cognition. We found that ECdelta (the difference in EC values pre- and post-COVID-19) significantly between COVID-19 and healthy participants in five brain regions; right intracalcarine cortex, right lingual gyrus, left hippocampus, left amygdala, left frontal orbital cortex. | |||||||||||||||||||||
309 | Serum Levels of the Parkinson's Disease-Linked Protein Parkin are Specifically Elevated in COVID-19 | 2024-10-02 | https://dx.doi.org/10.2139/ssrn.4972807 | Nadezhda G. Gumanova | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4972807 | High serum levels of the Parkinson’s disease-linked protein Parkin were associated with SARS-positive status (P<0.05) but were not associated with IgG-AdV-positive-status (IgG antibodies to adenovirus). These findings suggest considerable differences in inflammatory pathways or mitochondrial function in adenoviral infection versus SARS-CoV-2 infection. Mutations in the Parkin gene are associated with mitochondrial dysfunction, leading to neuronal death in Parkinson's disease. | |||||||||||||||||||||
310 | Exploring the characteristics and antecedents of clinically significant long COVID: A longitudinal cohort study | 2024-10-04 | https://doi.org/10.1016/j.lfs.2024.123114 | Chia-Chun Tang | https://www.sciencedirect.com/science/article/abs/pii/S0024320524007045 | A year post-infection, COVID-19's impact on cognitive function and health-related quality of life remains significant, affecting individuals and communities. There was a clinically significant decline in cognitive function and health-related quality of life over time, with symptoms like shortness of breath, reduced physical fitness, and increased health concerns. Those with severe acute COVID-19 symptoms experienced greater cognitive and physical declines and more shortness of breath a year later. | |||||||||||||||||||||
311 | Comparing personality traits of healthcare workers with and without long COVID: Cross-sectional stud | 2024-10-05 | https://doi.org/10.1002/pcn5.70017 | Keiko Saka | Participants with long COVID had poorer mental health according to HRQOL (health-related quality of life). The long COVID group had higher number of symptoms at the time of illness and higher NEO Five Factor Inventory Neuroticism scores than the non-long COVID group. They also had poorer mental health according to HRQOL than those without. | ||||||||||||||||||||||
312 | Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | 2024-10-07 | https://doi.org/10.1093/brain/awae215 | Catarina Rua | https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae215/7811070?login=false | We show evidence of brainstem pathophysiological changes associated with inflammatory processes in post-hospitalized COVID-19 survivors. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery. | |||||||||||||||||||||
313 | High Somatization Rates, Frequent Spontaneous Recovery, and a Lack of Organic Biomarkers in Post-Covid-19 Condition | 2024-10-08 | https://doi.org/10.1002/brb3.70087 | Anna Tröscher | https://onlinelibrary.wiley.com/doi/10.1002/brb3.70087 | PCC patients seen in a neurological outpatient department were followed for up to 18 months. Specific scores were positive for fatigue, insomnia, and sleepiness and were present in 95%, 62.1%, and 44.0%, respectively. Overall, 28% had a psychiatric disorder, including depression and anxiety. At the second visit (n = 92), fatigue (67.3%) and insomnia (45.5%) had decreased. At visit three (n = 43), symptom load had decreased in 76.8%; overall, 51.2% of patients were symptom-free. | |||||||||||||||||||||
314 | Macro- and Microstructural White Matter Differences in Neurologic Postacute Sequelae of SARS-CoV-2 Infection | 2024-10-10 | https://doi.org/10.3174/ajnr.A8481 | Erin E. O’Connor | https://www.ajnr.org/content/early/2024/10/10/ajnr.A8481 | NeuroPASC participants (neurologic postacute sequelae of SARS-CoV-2 infection) reported symptoms of lower concentration, higher fatigue, and impaired cognition compatible with WM (White Matter) syndrome. Psychometric testing confirmed these findings. NeuroPASC participants exhibited larger cerebral WM volume and higher WM mean kurtosis than NoCOVID controls. These findings suggest that immune dysregulation could influence WM properties to produce WM volume increases and consequent cognitive effects and headaches. | |||||||||||||||||||||
315 | Depression and related factors among patients with post-COVID-19 conditions: Cross-sectional, hospital-based study | 2024-10-10 | https://doi.org/10.1002/hsr2.70142 | Nguyen Thanh Binh | https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70142 | Depression was observed in 23.7% of respondents, categorized as mild (80.4%), moderate (16.5%), or severe (3.1%) based on PHQ-9 scores. The prevalence of depression among patients with post-COVID-19 conditions in the outpatient clinic was high. | |||||||||||||||||||||
316 | Post-COVID-19 memory complaints: Prevalence and associated factors | 2024-10-10 | https://doi.org/10.1016/j.nrleng.2024.09.001 | M. Ahmed | https://www.sciencedirect.com/science/article/pii/S2173580824000701 | Nearly one-fifth of the COVID-19 patients suffer from various degrees of memory complaints within one year. Memory complaints was prevalent in 19.2% of the post-COVID patients. Multiple logistic regression showed that individuals who recovered from COVID-19 within six to twelve months were more likely to have memory deficits. | |||||||||||||||||||||
317 | Long COVID-19 and Coexistence of Fatigue and Depression: A Cross-sectional Study from Saudi Arabia | 2024-10-14 | https://doi.org/10.1007/s44197-024-00312-7 | Abdulrahman Alharbi | https://pubmed.ncbi.nlm.nih.gov/39400651/ | The significant association between post-COVID-19 fatigue and depression highlights the need for psychological assessment of COVID-19 patients to enhance their post-infection quality of life. The prevalence of perceived fatigue was 22.7%, while fatigue measured by the Fatigue Severity Scale was 14.4%. The multivariable logistic regression model revealed that COVID-19 severity and depression were significant predictors of post-COVID-19 fatigue; adjusted odds ratio 1.87 and 14.3, respectively. | |||||||||||||||||||||
318 | Temporal trajectories of long-COVID symptoms in adults with 22 months follow-up in a prospective cohort study in Norway | 2024-10-14 | https://doi.org/10.1016/j.ijid.2024.107263 | Merete Ellingjord-Dale | https://www.ijidonline.com/article/S1201-9712(24)00334-5/fulltext | COVID-19 was associated with cognitive symptoms, anosmia, dysgeusia, dyspnoea and fatigue as well as worsening of overall health up to 22 months after a SARS-CoV-2 test, even when correcting for symptoms before the onset of COVID-19. Persistent symptoms reported more frequently by positive compared with negative participants one month after infection, were memory problems (3-6 months: adjusted odds ratio (aOR) = 6.8, CI = 5.7-8.1; >18 months: aOR = 9.4, CI = 4.1-22), and concentration problems (3-6 months: aOR = 4.1, CI = 3.5-4.7; >18 months: aOR = 4.4, CI = 2.0-9.7) as well fatigue, dyspnoea, anosmia and dysgeusia. | |||||||||||||||||||||
319 | Persistent dysfunctions of brain metabolic connectivity in long-covid with cognitive symptoms | 2024-10-15 | https://doi.org/10.1007/s00259-024-06937-x | Anna Lisa Martini | https://link.springer.com/article/10.1007/s00259-024-06937-x | The acute/subacute phase was characterized by hyperconnectivity in EXN and ATTN networks; the same networks showed hypoconnectivity in the chronic phase. EXN and ATTN hypoconnectivity was consistent with clinical findings in long-COVID patients, e.g. altered performances in neuropsychological tests of executive and attention domains. | |||||||||||||||||||||
320 | Cognitive outcomes and psychological symptoms in an Italian cohort with post-acute COVID-19 condition (PACC) | 2024-10-15 | https://doi.org/10.1016/j.heliyon.2024.e39431 | Alessandra Vergori | https://www.cell.com/heliyon/fulltext/S2405-8440(24)15462-X | We show a substantial proportion of PACC-CO (post-acute COVID-19 condition cognitive outcomes); hospitalization leads to impaired memory, anxiety and sleep disorders. post-acute COVID-19 condition. Overall, we found CO in 89 % of pts, in particular 88 % evaluated in w6M (within 6 months) and 89 % in b6M (beyond 6 months) while 90 % and 87 % in nPH and PH (not hospitalized patients and hospitalized patients), respectively. | |||||||||||||||||||||
321 | Evaluating Long-Term Autonomic Dysfunction and Functional Impacts of Long COVID: A Follow-Up Study | 2024-10-16 | https://doi.org/10.1101/2024.10.11.24315277 | Ella F. Eastin | https://www.medrxiv.org/content/10.1101/2024.10.11.24315277v1 | Evidence of persistent moderate to severe autonomic dysfunction was seen in 71.9% of Long COVID patients in our study, with a 36-month median symptom duration, suggesting that enduring autonomic dysfunction is highly prevalent in the Long COVID population. Moderate to severe autonomic dysfunction was significantly correlated with impaired function and capacity. | |||||||||||||||||||||
322 | Distinguishing pain profiles among individuals with long COVID | 2024-10-17 | https://doi.org/10.3389/fresc.2024.1448816 | Laura Tabacof | https://www.frontiersin.org/journals/rehabilitation-sciences/articles/10.3389/fresc.2024.1448816/full | 20.3% of individuals who reported new-onset pain had neuropathic pain, which was associated with lower quality of life and higher rates of cognitive dysfunction compared to those with non-neuropathic pain. | |||||||||||||||||||||
323 | Factors affecting the quality of life of patients with neurological manifestations of post-COVID syndrome | 2024-10-18 | https://doi.org/10.17116/jnevro202412409144 | A V Peretechikova | https://pubmed.ncbi.nlm.nih.gov/39435776/ | The results of the study indicate a deterioration in QoL in patients with PCS. The psychological domain of QOL was lower in patients with PCS, a decrease in vital activity, physical functioning, mental health has also been identified. | |||||||||||||||||||||
324 | Prevalence and measurement of post-exertional malaise in post-acute COVID-19 syndrome: A systematic review and meta-analysis | 2024-10-20 | https://doi.org/10.1016/j.genhosppsych.2024.10.011 | Yi An | https://www.sciencedirect.com/science/article/pii/S0163834324002160 | Our findings indicate that over half of the PACS individuals experience PEM (post-exertional malaise). The pooled prevalence of PEM among PACS patients at 3 months or more after COVID-19 diagnosis was 0.55 (95 % CI, 0.38, 0.71). | |||||||||||||||||||||
325 | Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs | 2024-10-21 | https://doi.org/10.1038/s41746-024-01286-3 | Shawn T. O’Neil | https://www.nature.com/articles/s41746-024-01286-3 | Several conditions are strongly increased in the PASC cohort, including Chronic fatigue syndrome, Malaise, Finding related to attentiveness, Headache, Migraine (with and without aura), and Anxiety disorder. Other neurological conditions increased in PASC include Inflammatory disease of the central nervous system, Disorder of autonomic nervous system, Polyneuropathy, Orthostatic hypotension, and Familial dysautonomia. | |||||||||||||||||||||
326 | Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination | 2024-10-22 | https://doi.org/10.1101/2024.10.19.24315794 | Anne Hege Aamodt, | https://www.medrxiv.org/content/10.1101/2024.10.19.24315794v1 | Altered plasma levels of soluble markers potentially reflecting changes in amyloid processing was found in patients with persistent headache after SARS-CoV-2 vaccine and particular in those with persistent headache after COVID-19 disease where we also found some association with cognitive symptoms. We found a strong and persistent upregulation of APP (amyloid precursor protein) in patients with headache after COVID-19 as compared to the two other groups. At both inclusion and after 6 months APP levels were also increased in those with accompanying cognitive symptoms. | |||||||||||||||||||||
327 | A systematic analysis of neurologic manifestations of Long COVID in Nigeria | 2024-10-24 | https://doi.org/10.1007/s13365-024-01232-9 | Iorhen Ephraim Akase | https://link.springer.com/article/10.1007/s13365-024-01232-9 | 4.6% of SARS-CoV-2 positive individuals contacted via telephone reported Neuro-PASC symptoms with a higher frequency in PNP (post-hospitalization Neuro-PASC) than in NNP (non-hospitalized Neuro-PASC) individuals ((23/200 (11.5%) vs. 83/2119 (3.9%), p = < 0.0001). The predominant neurologic symptoms at any time during the disease course were difficulty remembering / brain fog (63/106; 59.4%), fatigue (59/106; 55.7%), sleep problems (34/106; 32%), headache (33/106; 31%), paresthesia (12/106; 11.3%), and myalgia (10/106; 9.4%). | |||||||||||||||||||||
328 | Functional disabilities and adverse well-being by COVID-19 and Long COVID history and employment status: 2022 Behavioral Risk Factor Surveillance System | 2024-10-25 | https://doi.org/10.1002/ajim.23669 | Sharon R. Silver | https://onlinelibrary.wiley.com/doi/10.1002/ajim.23669 | 2022 prevalence of cognitive disability (16.4% of employees, 21.4% of the self-employed) and depression (31.2% and 36.4%, respectively) among workers reporting a history of Long COVID were more than double 2019 levels.The high prevalence of functional disabilities and adverse well-being among workers reporting a history of Long COVID have implications for workers and employers. | |||||||||||||||||||||
329 | Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review | 2024-10-27 | https://doi.org/10.1134/S1819712424700156 | N. V. Gulyaeva | https://link.springer.com/article/10.1134/S1819712424700156#citeas | It can be concluded that the mechanisms of neuropsychiatric complications of post COVID states are multifactorial, involving long-term damage to brain tissue as a result of direct or indirect viral damage to the central nervous system, prolonged systemic inflammation and neuroinflammation, oxidative stress, maladaptation of the blood coagulation systems, immune dysfunction, dysfunction of neurotransmitter systems and HPA axis, and psychosocial stress caused by social changes due to the pandemic. | |||||||||||||||||||||
330 | SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau | 2024-10-30 | https://doi.org/10.1371/journal.pone.0312834 | Motoki Imai | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312834 | In conclusion, infection of SARS-CoV-2 in TPH2-positive cells of the brain VTA may result in increased phosphorylation of tau through activation of GSK3β, induction of neuronal cell death, suppression of TPH2 expression, and decreased serotonin synthesis. . In addition, the present study shows that SARS-CoV-2 also infects and induced neuronal cell apoptosis in the olfactory bulb and cerebral cortex. It is also suggested that infection of the brain with SARS-CoV-2 may be associated with the development of neurological diseases such as AD (Alzheimer's Diseas) and PD (Parkinson’s disease). | |||||||||||||||||||||
331 | Long Coronavirus Disease and the Brain: Molecular Neuroimaging Insights into Neurologic and Psychiatric Sequelae | 2024-10-30 | https://doi.org/10.1016/j.cpet.2024.09.013 | Eric Guedj | https://pubmed.ncbi.nlm.nih.gov/39482218/ | This PET review synthesizes current evidence of the neurologic and psychiatric sequelae of COVID. This review also explores the pathophysiological mechanisms of these results, including astrocyte dysfunction and glutamate dysregulation, as well as the multimodal comparison to MR imaging findings. The findings underscore the potential for long-term brain injury. | |||||||||||||||||||||
332 | Socio-demographic and clinical predictors of post-acute, mid-and long-term psychological sequelae of COVID-19: a two-year cross-sectional investigation on 1317 patients at the University Hospital of Verona | 2024-10-31 | https://doi.org/10.1186/s13690-024-01426-x | C. Perlini | https://link.springer.com/article/10.1186/s13690-024-01426-x | Our data show that COVID-19 psychological sequelae tend to persist over time, still needing clinical attention and intervention planning, especially for females. Overall, 16% reported some form of clinically significant mental distress following the infection (HADS-TOT), with 13% and 6%, respectively, experiencing anxiety (HADS-Anxiety) and depressive symptoms (HADS-Depression). Finally, patients evaluated for the first time at 12- and 18 months showed a more significant impairment in mental and physical quality of life than those assessed at three months. | |||||||||||||||||||||
333 | Acute and long-term effects of COVID-19 on brain and mental health: A narrative review | 2024-11-03 | https://doi.org/10.1016/j.bbi.2024.11.007 | J. Douglas Bremner | https://www.sciencedirect.com/science/article/abs/pii/S0889159124006901 | Anxiety and mood disorders are elevated and seen in about 25% of Long COVID patients. Neuropsychological testing studies show a correlation between symptom severity and cognitive dysfunction, while brain imaging studies show global decreases in gray matter and alterations in olfactory and other brain areas. | |||||||||||||||||||||
334 | Fatigue >12 weeks after coronavirus disease (COVID) is associated with reduced reward sensitivity during effort-based decision making | 2024-11-06 | https://doi.org/10.1101/2024.11.04.621806 | Judith M. Scholing | https://www.biorxiv.org/content/10.1101/2024.11.04.621806v1 | The finding that fatigue is related to lower reward sensitivity >12 weeks after COVID, suggesting potential reward deficits in post-covid fatigue. Compared with no COVID and COVID <4 weeks groups, the COVID >12 weeks group reported higher state fatigue scores (mean±SD: 20±7 vs. 14±7 and 12±6 POMS-score, respectively) and was less sensitive to rewards (Reward*Group: OR: 0.35 and OR: 0.38). | |||||||||||||||||||||
335 | When fatigue and cognitive impairment persist- a neurological follow-up-study in patients with Post-COVID syndrome | 2024-11-07 | https://doi.org/10.1038/s41598-024-78496-y | Ann-Katrin Hennemann | https://www.nature.com/articles/s41598-024-78496-y | In this study 94 PCS patients were examined in median 9.4 (T1) and for a second time 14 months (T2) after mild to moderate SARS-CoV-2 infection. 47% of the patients reported an improvement of their symptoms over time, but only 12% full recovery. 4% noticed deterioration and 49% no change. But, significant fatigue and cognitive impairment persisted for more than 1 year after SARS-CoV-2 infection in both groups (with and without improvement). | |||||||||||||||||||||
336 | Blood Pressure Regulation in Post–COVID POTS: Beyond Sinus Tachycardia | 2024-11-11 | https://doi.org/10.1161/HYPERTENSIONAHA.124.23670 | Madeleine Johansson | https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.124.23670 | Patients with post–COVID-19 POTS (Postural orthostatic tachycardia syndrome) demonstrate higher mean 24-hour and nighttime SBP (systolic BP) and show disruptions of circadian BP rhythm regulation compared with population-based controls, as well as more daytime hypotensive episodes. | |||||||||||||||||||||
337 | Measuring subjective cognitive complaints with covid-19 brain fog using the subjective scale to investigate cognition (SSTICS) | 2024-11-12 | https://doi.org/10.1080/23279095.2024.2422926 | Emmanuel Stip | https://www.tandfonline.com/doi/full/10.1080/23279095.2024.2422926#abstract | Our study showed that >10% of patients reported subjective cognitive complaints following COVID-19, with most reporting mild or serious cognitive complaints, mostly within the domains of memory, attention, language, executive functioning or praxis. | |||||||||||||||||||||
338 | Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk | 2024-11-13 | https://doi.org/10.1038/s41598-024-79530-9 | Hongbei Xu | https://link.springer.com/article/10.1038/s41598-024-79530-9 | Two-sample MR analysis revealed a significant causal association of COVID 19 infection (odds ratio [OR] 1.2502, P = 0.0083; OR 1.4956, P = 0.0084), hospitalization (OR 1.0689, P = 0.0138; OR 1.0919, P = 0.0208), and severity (OR 1.0644, P = 0.0072; OR 1.0844, P = 0.0098) with increased risk of migraine and migraine with aura (MA). | |||||||||||||||||||||
339 | Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection | 2024-11-14 | https://doi.org/10.1038/s43587-024-00730-z | Ting Zhang | https://link.springer.com/article/10.1038/s43587-024-00730-z | Our work, combining multiple experimental and analytical methods, demonstrates the brain-wide impact of severe acute/subacute COVID-19, involving both cortical and subcortical regions. We observed a multi-regional antiviral response without direct active SARS-CoV2 infection. We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. | |||||||||||||||||||||
340 | Assessment of Post-COVID-19 Changes in Brain—Clinical and Imaging Evaluation Using MRI Vessel Wall Imaging and Complementary MRI Methods | 2024-11-15 | https://doi.org/10.3390/jcm13226884 | Jakub Okrzeja | https://www.mdpi.com/2077-0383/13/22/6884 | The changes observed in post-COVID-19 patients were: hyperintense foci (in the white matter of the brain hemispheres, in the lower parts of the temporal lobes, and in the structures of the posterior cranial fossa), presence of engorgement of deep medullary veins or perivascular enhancement, presence of inflammatory (concentric) vessel thickening in VWI images, changes in hippocampus size according to the MTA scale, presence of cortical atrophy, and thickening of the mucous membrane of the paranasal sinuses | |||||||||||||||||||||
341 | Examining Brain Structures and Cognitive Functions in Patients with Recovered COVID-19 Infection: A Multicenter Study Using 7T MRI | 2024-11-15 | https://doi.org/10.1101/2024.11.13.24317121 | Jr-Jiun Liou | https://www.medrxiv.org/content/10.1101/2024.11.13.24317121v1 | Our results indicate that hospitalized COVID-19 cases show lower hippocampal volume when compared to non-hospitalized participants. We also show that WMH (white matter hyperintensity) and hippocampal volumes correlate with worse cognitive scores in hospitalized patients compared with non-hospitalized participants, potentially indicating recent lesions and atrophy. | |||||||||||||||||||||
342 | Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina | 2024-11-18 | https://doi.org/10.1186/s12883-024-03959-8 | Sol A. Cataldo | https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-024-03959-8 | This study highlights the enduring impact of long COVID on quality of life and physical activity, with specific brain structural changes identified two years post-infection. Long COVID patients reported persistent cognitive symptoms such as memory problems and brain fog, with higher levels of fatigue and reduced quality of life compared to controls. MRI analysis revealed decreased volume in the cerebellum (p = 0.03), lingual gyrus (p = 0.04), and inferior parietal regions (p = 0.03), and reduced cortical thickness in several areas, including the left and right postcentral gyri (p = 0.02, p = 0.03) and precuneus (p = 0.01, p = 0.02). | |||||||||||||||||||||
343 | Impact of COVID-19 disease and COVID-19 vaccinations on hospital admissions for neurological diseases in the Lombardia over-12 population. Data from a self-controlled case series analysis | 2024-11-19 | https://doi.org/10.1007/s10072-024-07870-5 | Andrea Salmaggi | https://link.springer.com/article/10.1007/s10072-024-07870-5 | Our data suggest that the increased risk of non-inflammatory CNS (central nervous system) disorders following COVID-19 vaccination is lower than the risk conferred by COVID-19 infection, and that COVID-19 infection increases the risk of some inflammatory and non inflammatory neurological disorders. When the risk conferred by COVID19 infection was assessed in the same cohort, significant IRR were greater in the occurrence of ischemic stroke, cerebral haemorrhage, and TIAs (IRR 5.6, 3.62, 6.83) and includes also Multiple Sclerosis, neuromyelitis, and polymyositis (5.25, 8.81, 5.67). | |||||||||||||||||||||
344 | Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study | 2024-11-20 | https://doi.org/10.3390/brainsci14111161 | Justyna Jachman-Kapułka | https://www.mdpi.com/2076-3425/14/11/1161 | The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations. Neurological manifestations were observed in 55.4% of patients, and the most frequent were delirium, headache, myalgia, dizziness, cerebrovascular diseases, and encephalopathy. In subsequent periods of Omicron dominance, a higher frequency of neurological manifestations such as delirium, transient ischemic attack (TIA), and encephalopathy was observed. | |||||||||||||||||||||
345 | SARS-CoV-2 Nsp7 plays a role in cognitive dysfunction by impairing synaptic plasticity | 2024-11-20 | https://doi.org/10.3389/fnins.2024.1490099 | Jiazheng Guo | https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1490099/full | Our findings underscore the crucial role of SARS-CoV-2 Nsp7 in cognitive dysfunction, which is potentially mediated through impaired synaptic plasticity via mitochondrial damage. | |||||||||||||||||||||
346 | Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies | 2024-11-21 | https://doi.org/10.3390/v16121811 | Aliteia-Maria Pacnejer | https://www.mdpi.com/1999-4915/16/12/1811 | This review highlights the wide range of neurological and psychiatric symptoms associated with COVID-19, from mild conditions such as headache and anosmia to severe complications such as stroke and encephalopathy. Long-term neuropsychiatric disorders, including cognitive dysfunction, anxiety, and depression, highlight the long-term consequences of SARS-CoV-2 infection. | |||||||||||||||||||||
347 | Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle-Age Adults | 2024-11-22 | https://doi.org/10.1002/ana.27128 | Natasha A. Choudhury | https://onlinelibrary.wiley.com/doi/10.1002/ana.27128 | There were significant age-related differences in subjective impression of fatigue and sleep disturbance in the NNP (non-hospitalized Neuro-PASC) group, commensurate with higher impairment in quality of life (QoL) among younger patients. Finally, there were significant age-related differences in objective executive function and working memory in NNP patients, with the worst performance coming from the younger group. | |||||||||||||||||||||
348 | Changes in olfactory bulb volume and olfactory sulcus depth in COVID-19 infection: an autopsy study | 2024-11-23 | https://doi.org/10.1007/s00405-024-09077-y | Sefa Sonmez | https://link.springer.com/article/10.1007/s00405-024-09077-y | Autopsy findings showed damage in olfactory center sections in COVID-19 group. In the autopsy cases examined, it was found that there was a significant decrease in bilateral olfactory bulb (OB) and olfactory tract (OT) volumes in COVID-19 group (p < 0.001). | |||||||||||||||||||||
349 | Fatigue and cognitive dysfunction in previously hospitalized patients with COVID-19: A 1-year follow-up | 2024-11-25 | https://doi.org/10.1371/journal.pone.0314131 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11588221/ | Ingrid Andreasson | https://pubmed.ncbi.nlm.nih.gov/39585884/#:~:text=Conclusion%3A%20In%20the%20first%20year,in%20other%20domains%20were%20limited. | Analyzes of Z-scores for MoCA indicated improvement over the year, however the results were 1 SD below norm at all assessments. CFQ (Cognitive Failure Questionnaire) scores indicated cognitive impairment, and the sum scores for MFI reflected a relatively high degree of fatigue at follow-up. | ||||||||||||||||||||
350 | Changes in cerebral glucose metabolism among mild long COVID patients: an [18F]FDG PET/CT study | 2024-11-25 | https://doi.org/10.1590/1414-431X2024e14228 | J.S. Sakamoto | https://www.scielo.br/j/bjmbr/a/QKhYGzgQmMj5wvmLNqmvp3x/?lang=en | Our study did not find significant glycolytic metabolic changes in patients with mild long COVID. However, our results showed discrete cerebral glycolytic metabolism findings, manifesting as hypometabolism and hypermetabolism, among patients experiencing mild long COVID symptoms. This [18F]FDG cerebral PET/CT study identified alterations in cerebral metabolism in patients with mild long COVID compared to healthy individuals. A small percentage of patients were found to have significant hypometabolism or hypermetabolism in different brain cortical regions. | |||||||||||||||||||||
351 | Assessment of cognitive and psychiatric disturbances in people with post-COVID-19 condition: a cross-sectional observational study | 2024-11-25 | 10.1017/S1092852924002153 | Federico Masserini | https://www.cambridge.org/core/journals/cns-spectrums/article/assessment-of-cognitive-and-psychiatric-disturbances-in-people-with-postcovid19-condition-a-crosssectional-observational-study/3333EDCD308D03617FBEC2D1820BFA5A | Consecutive patients, referred by the infectious disease specialist because of cognitive complaints after COVID-19, were neurologically evaluated Acute infection severity was low for most patients and the most common persisting symptoms were fatigue (92%), sleep problems (69.5%), and headache (52.4%). MoCA outlined cognitive deficits in ≥1 cognitive domain in 34% of patients, mainly in memory and attention. About 60% of patients presented depressive, anxiety, or stress-related symptoms. | |||||||||||||||||||||
352 | Self-reported health, persistent symptoms, and daily activities 2 years after hospitalization for COVID-19 | 2024-11-27 | 10.3389/fncel.2024.1460119 | Roda Alhasan | https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1460119/abstract | For some individuals regardless of age, sex or COVID-19 severity, respiratory symptoms and fatigue may persist for up to 2 years following COVID-19. The majority of participants reported present respiratory symptoms (n = 83, 69%) and fatigue (n = 98, 78%) at the 2-year follow-up. Persistent respiratory symptoms and fatigue impacted functional status substantially (p = <0.001, p = 0.028, respectively). | |||||||||||||||||||||
353 | Insight into potential Long COVID effects: antidepressant use in post SARS-CoV-2 Infection scenarios. A Multiregional Nested Case-Control Study | 2024-11-28 | https://doi.org/10.1016/j.psychres.2024.116290 | Valentina Rosolen | https://www.sciencedirect.com/science/article/abs/pii/S0165178124005754 | The results of this study confirm the role of SARS-CoV-2 infection as a risk factor for the onset of neuropsychiatric symptoms. Findings showed that individuals previously infected with SARS-CoV-2 had a higher risk of receiving a new prescription of antidepressants. Moreover, this association was stronger among subjects hospitalized due to infection, and SARS-CoV-2 vaccination may have acted as an effect modifier by reducing that risk. | |||||||||||||||||||||
354 | Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 | 2024-11-29 | https://doi.org/10.1016/j.chom.2024.11.007 | Zhouyi Rong | https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00438-4 | We observed the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients, persisting long after viral clearance. Further, biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients. Our findings suggest persistent spike protein at the brain borders may contribute to lasting neurological sequelae of COVID-19. | |||||||||||||||||||||
355 | SARS-CoV-2 infection and risk of subsequent demyelinating diseases: national register–based cohort study | 2024-11-29 | https://doi.org/10.1093/braincomms/fcae406 | Scott Montgomery | https://academic.oup.com/braincomms/article/6/6/fcae406/7909395 | Rates (non-multiple sclerosis demyelinating disease) per 100 000 person-years (and 95% confidence intervals) were 3.8 (3.6–4.1) among those without a COVID-19 diagnosis and 9.0 (5.1–15.9) among those admitted to hospital for COVID-19, with an adjusted hazard ratio and (and 95% confidence interval) of 2.35 (1.32–4.18, P = 0.004). Equivalent associations with multiple sclerosis (28 individuals had this outcome among the exposed) were rates of 9.5 (9.1–9.9) and 21.0 (14.5–30.5) and an adjusted hazard ratio of 2.48 (1.70–3.61, P < 0.001). | |||||||||||||||||||||
356 | Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitive symptoms: a pilot study | 2024-11-29 | https://doi.org/10.1101/2024.11.28.24318139 | Michael R Lawrence | https://www.medrxiv.org/content/10.1101/2024.11.28.24318139v1 | The long COVID group had significantly lower ratings than controls on quality of life, physical health, emotional functioning, and psychological well-being. Serum levels of nerve growth factor (NGF), a biomarker of brain plasticity, were significantly lower in the long COVID group, which was significantly more likely than controls to have serum levels of inflammatory marker (interleukin (IL)-10) values greater than or equal to the median (p=0.015). | |||||||||||||||||||||
357 | Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests | 2024-12-03 | https://doi.org/10.1016/j.bbih.2024.100917 | Aysha Mohamed Rafik Patel | https://www.sciencedirect.com/science/article/pii/S2666354624001959?via%3Dihub | The LCCAB (Long COVID Cognitive Assessment Battery) detected cognitive impairments in nearly 90% of participants, primarily affecting attention, executive function, and processing speed. The overall sample had a mean ACE-III score of 91/100 (SD 6) with 15.7% (16/102) scoring at or below the cut-off score considered to represent objective cognitive impairment. Of the 20 individuals who also completed the LCCAB, 89.47% were impaired on at least one task, primarily in the domains of attention, executive function and processing speed. | |||||||||||||||||||||
358 | Structural MRI correlates of cognitive and neuropsychiatric symptoms in Long COVID: a pilot study | 2024-12-03 | https://doi.org/10.3389/fpsyt.2024.1412020 | Shantanu H. Joshi | https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1412020/full | Our findings provide supporting evidence for cortical hypertrophy in Long COVID. Results showed increased cortical thickness in the caudal anterior, isthmus, and the posterior cingulate gyrus as well as the rostral middle frontal gyrus respectively along with higher gray matter volume in the posterior cingulate and the isthmus cingulate in patients with Long COVID. | |||||||||||||||||||||
359 | Phase-dependent trends in the prevalence of myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) related to long COVID: A criteria-based retrospective study in Japan | 2024-12-09 | https://doi.org/10.1371/journal.pone.0315385 | Satoru Morita | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0315385 | The proportion of long COVID patients who developed ME/CFS strictly diagnosed by three criteria was lower among patients infected in the Omicron phase than among patients infected in the other phases, while the proportion of patients with brain fog inversely increased. The frequency of ME/CFS decreased from 23.9% in the Preceding period to 13.7% in the Delta-dominant period and to 3.3% in the Omicron-dominant period. In the ME/CFS group, the proportion of patients complaining of brain fog significantly increased from 22.2% in the Preceding period to 47.9% in the Delta period and to 81.3% in the Omicron period. | |||||||||||||||||||||
360 | COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students | 2024-12-09 | https://doi.org/10.1016/j.bbi.2024.12.002 | Ronan McNeill | https://www.sciencedirect.com/science/article/pii/S0889159124007311 | Previously infected students exhibited distinct prefrontal haemodynamic patterns during cognitive engagement, reminiscent of those observed in adults four decades older, and this appeared to be especially true if they reported experiencing brain fog due to COVID-19. We observed that 40 % retrospectively self-reported cognitive impairment (brain fog) due to COVID-19 and 37 % exhibited objective evidence of cognitive impairment (assessed via computerised testing), with some suggestion that executive functioning may have been particularly affected | |||||||||||||||||||||
361 | Neuropsychological outcome of indoor rehabilitation in Post-Covid-19 condition-results of the PoCoRe study | 2024-12-10 | 10.3389/fneur.2024.1486751 | Michael Jöbges | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1486751/abstract | The PoCoRe study highlights the high prevalence of neuropsychological deficits and fatigue in PCC patients, with notable improvements observed following multidisciplinary rehabilitation. The prevalence of fatigue on admission was high (84.6%) and decreased significantly by discharge (77.4%), with a mild effect size. Reaction times on the alertness subtest were abnormal in 70% of patients on admission and 50% on discharge. Sustained attention was abnormal in 55% of patients on admission, decreasing to 43% on discharge. These differences were significant with mild effect sizes. | |||||||||||||||||||||
362 | Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID | 2024-12-10 | https://doi.org/10.1093/braincomms/fcae448 | Shreya Mukherjee | https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcae448/7920652?login=false | An average of 10 months after symptom onset, the three most common neurological symptoms for PNP (post-hospitalization Neuro-PASC) patients were brain fog (86.5%), numbness/tingling (56.5%), and headache (56.5%). For NNP (non-hospitalized Neuro-PASC) patients, the three most common neurological symptoms were brain fog (83.9%), headache (70.9%), and dizziness (53.8%). Both PNP and NNP patients had impaired quality of life in cognitive, fatigue, sleep, anxiety, and depression domains. | |||||||||||||||||||||
363 | Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection | 2024-12-12 | https://doi.org/10.1016/j.bandc.2024.106254 | Christopher E. Niemczak | https://www.sciencedirect.com/science/article/abs/pii/S0278262624001313 | The relationship between brain activation and scores on the 2-back did differ between groups, with the PASC group showing more frontal activation. Findings suggest that individuals with PASC and CF may need to exert greater mental effort during demanding cognitive tasks, reflected in recruitment of a broader network of brain regions. | |||||||||||||||||||||
364 | A Two-Year cohort study examining the impact of cytokines and chemokines on cognitive and psychiatric outcomes in Long-COVID-19 patients | 2024-12-12 | https://doi.org/10.1016/j.bbi.2024.12.006 | Felipe Couto Amendola | https://www.sciencedirect.com/science/article/abs/pii/S0889159124007372 | The GAM (Generalized Additive Models) analysis revealed significant associations between acute COVID-19 severity and Epworth Sleepiness Score with persistent anxiety symptoms at T2 (mean 23.5 months). For depression, both WHO severity class and Eotaxin levels were significant predictors. | |||||||||||||||||||||
365 | Investigating autonomic dysfunction in post-COVID-19 syndrome from skin to brain: A case-control study using EMG-SSR and fNIRS | 2024-12-13 | https://doi.org/10.1016/j.brainresbull.2024.111158 | Jia-Yin Ma | https://www.sciencedirect.com/science/article/pii/S0361923024002922?via%3Dihub | Our findings suggest that there were alternations in both central and peripheral parts of ANS (autonomic nervous system) in PCS patients. Notable findings included prolonged latencies of palmar SSR, a strengthened sub-network in the fronto-parietal cortex, altered node degrees and efficiency in left sensorimotor cortex and right dorsolateral prefrontal cortex (DLPFC). | |||||||||||||||||||||
366 | Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis | 2024-12-15 | https://doi.org/10.1186/s12877-024-05538-5 | Dan Shan | https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-024-05538-5 | Across a median observation period of 12 months post-COVID, the overall incidence of NOD (new-onset dementia) was about 1.82% in the COVID-infected group, compared to 0.35% in the non-COVID-infected group. The overall pooled meta-analysis showed a significantly increased NOD risk among COVID-19 older adult survivors compared to non-COVID-19 controls (RR = 1.58, 95% CI 1.21–2.08). | |||||||||||||||||||||
367 | Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem | 2024-12-16 | https://doi.org/10.1101/2024.12.16.628627 | Anthony Coleon | https://www.biorxiv.org/content/10.1101/2024.12.16.628627v1 | Using the golden hamster as a model, we provide further evidence that SARS-CoV-2 is neuroinvasive and can persist in the central nervous system, as we found viral RNA and replicative virus in the brainstem after 80 days of infection. Finally, the infected hamsters manifested persistent signs of depression and impaired short-term memory, as well as late-onset signs of anxiety. | |||||||||||||||||||||
368 | Risk factors of long-term brain health outcomes after hospitalization for critical illness | 2024-12-16 | https://doi.org/10.1007/s00415-024-12786-3 | C. Peinkhofer | https://link.springer.com/article/10.1007/s00415-024-12786-3 | Brain health is comparably impaired after hospitalization for critical illness and COVID-19. Brain health was impaired in 76% of patients (72% critical illness, 81% COVID-19; p = 0.14) at 18-month follow-up. | |||||||||||||||||||||
369 | The Effects of COVID-19 on Anxiety and Depressive Symptoms Among Chinese College Students: Chain Mediation of Three Long COVID-19 Symptoms | 2024-12-19 | https://doi.org/10.1080/00223980.2024.2437382 | Yuanyuan Deng | https://www.tandfonline.com/doi/full/10.1080/00223980.2024.2437382 | The results showed that ∼80% of Chinese college students suffered COVID-19 in late 2022 and early 2023, and 47.8, 35.4, 43.8, 37, and 54.3% of the participants had at least one somatic symptom, insomnia, fatigue, anxiety, and depressive symptoms, respectively, about 2–3 months after onset. This study revealed that the influence of COVID-19 on anxiety and depressive symptoms is not determined by the severity of COVID-19 in acute phase but by long COVID. | |||||||||||||||||||||
370 | Personality and neuropsychiatric symptoms in individuals diagnosed with long COVID | 2024-12-19 | https://doi.org/10.1186/s12879-024-10308-0 | Asia Avinir | https://link.springer.com/article/10.1186/s12879-024-10308-0 | Individuals diagnosed with long COVID exhibit diverse neuropsychiatric symptoms, with depression symptoms and sleep disturbances being particularly prominent. Findings showed high rates of depressive disorders (45.6%), generalized anxiety disorders (21%), sleep disturbances (76.3%), and reported cognitive changes (94.7%). | |||||||||||||||||||||
371 | New-onset refractory status epilepticus after SARS-CoV-2 infection: a review of literature | 2024-12-27 | https://doi.org/10.3325/cmj.2024.65.510 | Athanasios Stavropoulos | https://pmc.ncbi.nlm.nih.gov/articles/PMC11748445/ | While post-COVID NORSE (new-onset refractory status epilepticus) is an uncommon adverse event associated with SARS-CoV-2, its severity and possible fatal consequences underscore the necessity for additional research. Notably, NORSE can manifest weeks, months, or even a year following the initial viral infection. While NORSE is uncommon, it carries a high mortality rate and can result in permanent epilepsy. | |||||||||||||||||||||
372 | SARS-CoV-2 membrane protein induces neurodegeneration via affecting Golgi-mitochondria interaction | 2024-12-27 | https://doi.org/10.1186/s40035-024-00458-1 | Fang Wang | https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00458-1 | this study shows that expression of SARS-CoV-2 M causes hippocampal atrophy, neuronal apoptosis, glial cell activation, Golgi apparatus and mitochondrial damage. M induces mitochondrial fragmentation and neuronal death via disruption of PI(4)P-mediated Golgi-mitochondrial communication. These findings provide a potential mechanism for long-lasting neurological symptoms of COVID-19 infection. | |||||||||||||||||||||
373 | Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae | 2024-12-28 | https://doi.org/10.1038/s41598-024-82180-6 | Rupal Dhariwa | https://www.nature.com/articles/s41598-024-82180-6 | The research thus, identifies a significant association between post-COVID-19 syndrome and dysregulated pathways, including oxidative phosphorylation, inflammatory processes, and extracellular matrix-related mechanisms. The significance of sustained systemic inflammation and blood–brain barrier (BBB) dysfunction in post-COVID-associated brain fog and its potential link to Alzheimer’s probability in the future is notable as the persistent inflammation, promoting brain fog condition creates a cognitive impairment condition in patients. | |||||||||||||||||||||
374 | Biochemical changes in subregions of the cingulate gyrus in patients with post-COVID syndrome | 2025-01-07 | https://doi.org/10.1140/epjs/s11734-024-01444-4 | Artem Trufanov | https://link.springer.com/article/10.1140/epjs/s11734-024-01444-4 | The study showed significant hypofunction in all subregions of the cingulate gyrus in patients with post-COVID syndrome. The wide diversity of roles performed by this brain structure accounts for the vast variety of clinical pictures covering not only cognitive impairments but also psychological and emotional consequences, as well as pronounced asthenisation. | |||||||||||||||||||||
375 | Structural and functional changes in the brain during post-COVID syndrome: neuropsychological and MRI study | 2025-01-07 | https://doi.org/10.1140/epjs/s11734-024-01448-0 | Artem Trufanov | https://link.springer.com/article/10.1140/epjs/s11734-024-01448-0 | Mild and moderate novel CoV disease (SARS)-CoV-2 leads to atrophy of the accessory nucleus on both sides. However, clinically significant is the decrease in the volume of the dominant nucleus, which is associated with a decrease in functional connectivity in the structures of the DMN (Default Mode Network) and VN (vestibular nuclei) as well as an increase in FA i(Fractional anisotropy) n the conductors of the white matter of the brain that connect predominantly the cognitive zones of the cortex and subcortical nuclei | |||||||||||||||||||||
376 | Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID | 2025-01-07 | https://doi.org/10.1093/braincomms/fcae448 | Shreya Mukherjee | https://academic.oup.com/braincomms/article/7/1/fcae448/7920652?login=false | An average of 10 months after symptom onset, the three most common neurological symptoms for PNP (post-hospitalization Neuro-PASC) patients were brain fog (86.5%), numbness/tingling (56.5%) and headache (56.5%).For NNP (non-hospitalized Neuro-PASC) patients, the three most common neurological symptoms were brain fog (83.9%), headache (70.9%) and dizziness (53.8%). PNP patients performed worse on National Institutes of Health Toolbox tests of processing speed, attention, executive function and working memory than a US normative population whereas NNP patients had lower results in processing, speed, attention and working memory. | |||||||||||||||||||||
377 | Does SARS-CoV-2 Infection Increase Risk of Neuropsychiatric and Related Conditions? Findings from Difference-in-Differences Analyses | 2025-01-08 | https://doi.org/10.21203/rs.3.rs-5621095/v1 | Yong Chen | https://www.researchsquare.com/article/rs-5621095/v1 | Children (5-12) faced increased risks for anxiety, OCD, ADHD, autism, and other conditions, while youths (12-20) exhibited elevated risks for anxiety, suicidality, depression, and related symptoms. The key findings from our study show that both children and youth in the COVID-19 positive groups retained significant risk differences compared to their respective negative groups for the composite neuropsychiatric outcome. | |||||||||||||||||||||
378 | The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19 | 2025-01-09 | https://doi.org/10.1016/j.neuroimage.2025.121011 | Xuan Niu | https://www.sciencedirect.com/science/article/pii/S1053811925000114 | Our findings are the first to support the role of the frontal-limbic network (i.e., the DLPFC [dorsolateral prefrontal cortex] and dACC [dorsal anterior cingulate cortex]) in individual fatigue susceptibility after mild COVID-19. GMV (gray matter volume) in the DLPFC and dACC in the COV+ group were associated with fatigue and had an indirect negative effect on co-occurring neuropsychiatric symptoms in the acute and chronic stages mediated by acute fatigue in the COV+ group. | |||||||||||||||||||||
379 | Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory | 2025-01-11 | https://doi.org/10.1038/s41598-025-85919-x | Jeyanthan Charles James | https://link.springer.com/article/10.1038/s41598-025-85919-x | Neurologic PCS patients had more complaints with significantly higher fatigue scores as well as higher levels of depressive and anxiety symptoms compared to Non-PCS and HC (Healthy Controls). Deep neuropsychological assessment showed that neurologic PCS patients performed worse in a general screening of cognitive deficits compared to HC. Neurologic PCS patients showed impaired mental flexibility as an executive subfunction, verbal short-term memory, working memory and general reactivity (prolonged reaction time). | |||||||||||||||||||||
380 | Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study | 2025-01-13 | https://doi.org/10.1007/s11606-024-09290-9 | Suzanne D. Vernon | https://link.springer.com/article/10.1007/s11606-024-09290-9 | ME/CFS is a diagnosable sequela that develops at an increased rate following SARS-CoV-2 infection. The incidence rate of ME/CFS in participants followed from time of SARS-CoV-2 infection was 2.66 (95% CI 2.63–2.70) per 100 person-years while the rate in matched uninfected participants was 0.93 (95% CI 0.91–10.95) per 100 person-years: a hazard ratio of 4.93 (95% CI 3.62–6.71). | |||||||||||||||||||||
381 | Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study | 2025-01-13 | https://doi.org/10.1371/journal.pone.0316625 | Kiran Thapaliya | https://pmc.ncbi.nlm.nih.gov/articles/PMC11729965/ | Hippocampal alterations may contribute to the neurocognitive impairment experienced by long COVID and ME/CFS patients. Our study found significantly larger volumes in the left hippocampal subfields of both long COVID and ME/CFS patients compared to HC. Additionally, we found significant associations between hippocampal subfield volumes and severity measures of ‘Pain’, ‘Duration of illness’, ‘Severity of fatigue’, ‘Impaired concentration’, ‘Unrefreshing sleep’, and ‘Physical function’ in both conditions. | |||||||||||||||||||||
382 | Clinical Characteristics of COVID-19-Related Reversible Cerebral Vasoconstriction Syndrome: A Systematic Review of Case Series | 2025-01-14 | https://doi.org/10.3390/jcm14020487 | Raon Jung | https://www.mdpi.com/2077-0383/14/2/487 | While the recovery rate of vasoconstriction on brain angiographic findings was not uncommon, our systematic review indicates a potential for a relatively poor neurological prognosis in COVID-19-related RCVS (reversible cerebral vasoconstriction syndrome). Among the included patients, 12 (50.0%) experienced strokes as a complication of RCVS, and the mortality rate was 9.1%. Follow-up imaging findings were available for 14 of the 24 cases (58.3%). Among these, vasoconstriction was fully improved in 64.3%, partially improved in 28.6%, and aggravated in 7.1%. | |||||||||||||||||||||
383 | Choroid plexus volume is enlarged in long COVID and associated with cognitive and brain changes | 2025-01-15 | https://doi.org/10.1038/s41380-024-02886-x | Maria Diez-Cirarda | https://www.nature.com/articles/s41380-024-02886-x | ChP (choroid plexus) volume enlargement in PCC compared to healthy controls. The ChP enlargement was associated with cognitive dysfunction, grey matter volume reduction in frontal and subcortical areas, white matter integrity and diffusivity changes and functional connectivity changes. | |||||||||||||||||||||
384 | Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months | 2024-12-19 | https://doi.org/10.1080/07853890.2025.2453082 | Gopika Gopinath | https://www.tandfonline.com/doi/full/10.1080/07853890.2025.2453082#abstract | Young adults who had COVID-19 infection approximately 28 months ago show minimal long-term impact on cognitive function and autonomic regulation. However, subtle cognitive inefficiencies persist, particularly in working memory and executive function tasks. | |||||||||||||||||||||
385 | Executive Function Deficit in Patients with Long COVID Syndrome: A Systematic Review | 2025-01-19 | https://doi.org/10.1016/j.heliyon.2025.e41987 | Siti Maisarah Nasir | https://www.cell.com/heliyon/fulltext/S2405-8440(25)00367-6 | Overall, EF (executive function) is predominantly impaired in patients with long COVID, which resulted in reduced performance in other neurocognitive domains.The present study also revealed that EF deficits in long COVID patients are correlated with disruptions in the frontal and cerebellar regions, affecting processes such as nonverbal reasoning, executive aspects of language, and recall. This consistent disturbance also emphasised the correlation between EF deficits and brain alterations in patients with long COVID. | |||||||||||||||||||||
386 | Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 | 2025-01-20 | https://doi.org/10.1186/s13256-024-05006-z | Nathane Braga da Silva Rezende | https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-024-05006-z#citeas | Encephalitis is a rare complication of SARS-CoV-2 infection. Beyond a year from onset, encephalitis continues to impact patients’ quality of life, particularly in terms of mobility, cognitive function, and mood disorder. Further research is essential to uncover the underlying mechanisms and develop targeted interventions for long-term management. | |||||||||||||||||||||
387 | Unclosing Clinical Criteria and the Role of Cytokines in the Pathogenesis of Persistent Post-COVID-19 Headaches: A Pilot Case-Control Study from Egypt | 2025-01-22 | https://doi.org/10.3390/ctn9010005 | Ahmed Abualhasan | https://www.mdpi.com/2514-183X/9/1/5 | Persistent post-COVID-19 headaches have diverse clinical characteristics and are associated with elevated circulating levels of pro-inflammatory cytokines, suggesting a potential underlying neuroinflammation. Post-COVID headaches predominantly presented as bilateral (53.6%) and throbbing (60.7%) in nature, with a median of 12 headache days per month and high pain intensity (median VAS score = 80). | |||||||||||||||||||||
388 | Cognitive impairment, depressive and anxiety disorders among post-COVID-19 survivors: a follow-up study | 2025-01-22 | https://doi.org/10.1186/s43045-025-00502-4 | Ayman A. Aziz | https://link.springer.com/article/10.1186/s43045-025-00502-4 | Impairment of cognitive functions; especially delayed recall; was one of the important COVID-19 psychiatric sequelae, In addition to anxiety and depressive signs in the form of depressed/anxious mood, fatigue, decreased concentration, and sleep disturbances. SCID-I showed that 43.2% of our sample was diagnosed with both anxiety and depression at 1 month post-recovery, with the improvement of some cases at 3 months to affect only 18.2%. The percentage of patients who suffered from sleep difficulties was 59.1% at 1st interview and 27.3% at 2nd interview. While 61.4% of patients suffered from fatigue and low concentration at 1st interview and went down to 31.8% at 2nd interview. | |||||||||||||||||||||
389 | Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance | 2025-01-22 | https://doi.org/10.1007/s10286-025-01106-y | Aitana Ruiz de Lazcano | https://link.springer.com/article/10.1007/s10286-025-01106-y | Higher rates of anxious–depressive symptomatology are also found in the three clinical groups compared with the control group. The results suggest that anxious–depressive symptoms may significantly influence the cognitive performance of patients with LC and POTS. After controlling for these psychological factors, working memory, attention, and verbal fluency emerged as the most affected cognitive domains. | |||||||||||||||||||||
390 | Altered brain glucose metabolism in COVID-19 disease: an activation likelihood estimation meta-analysis of PET studies | 2025-01-24 | https://doi.org/10.1007/s11682-025-00966-2 | Dongju Kang | https://link.springer.com/article/10.1007/s11682-025-00966-2 | COVID-19 disease impacts brain glucose metabolism, typically manifesting as areas of decreased metabolism in 18F-FDG PET scans, though increases are also observed. Significant increases in brain glucose metabolism were noted in the left anterior cingulate gyrus, right thalamus, and brainstem. | |||||||||||||||||||||
391 | Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies | 2025-01-24 | https://doi.org/10.31083/RN37385 | María Alejandra Tudorache Pantazi | https://www.imrpress.com/journal/RN/79/12/10.31083/RN37385 | Cognitive problems in Long COVID persist over time and improve slowly, although studies seem to agree that most areas improved significantly after one year. The cognitive functions that remained impaired the longest were processing speed and attention. These cognitive alterations cause a reduction in the quality of life of the patients and a reduction in work capacity and manifest the need for a cognitive intervention. | |||||||||||||||||||||
392 | Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching | 2025-01-25 | https://doi.org/10.1631/jzus.B2300831 | Shixu Du | https://link.springer.com/article/10.1631/jzus.B2300831 | Nearly half (48.80%) of the COVID-19 survivors reported sleep disturbance. Univariate analyses revealed that PCSD was related to worse ICA (Integrated Cognitive Assessment) and NOT (Number Ordering Test) performance (P<0.05). Underlying disease, upper respiratory infection, loss of smell or taste, severe pneumonia, and self-reported cognitive complaints were associated with worsened neurocognitive performance among PCSD (of post-COVID-19 sleep disturbance) individuals (P<0.05). | |||||||||||||||||||||
393 | Comprehensive neuropsychological assessment and predictors of cognitive functioning at six months after COVID-19 in patients treated in the ICU, regular hospital ward, or isolated at home | 2025-01-25 | https://doi.org/10.1080/23279095.2025.2454352 | Riikka Pihlaja | https://pubmed.ncbi.nlm.nih.gov/39862139/ | Results showed no significant differences in cognitive test performance of impairment frequencies between COVID-19 groups and controls. However, patients with COVID-19 reported higher levels of subjective cognitive symptoms, depressive symptoms, and fatigue compared to controls. | |||||||||||||||||||||
394 | Exploring the experiences of cognitive symptoms in Long COVID: a mixed-methods study in the UK | 2025-01-25 | https://doi.org/10.1136/bmjopen-2024-084999 | Amy Miller | https://pubmed.ncbi.nlm.nih.gov/39863405/ | Reduced cognitive ability was among the most prevalent symptoms reported by the study participants. Cognitive dysfunction in LC appears to be exacerbated by vicious cycle of withdrawal from daily life including loss of employment, physical inactivity and social isolation driving low mood, anxiety and poor cognitive functioning. | |||||||||||||||||||||
395 | Neurological syndromes associated with COVID-19: a multicenter study in Brazil | 2025-01-27 | https://doi.org/10.1186/s12879-025-10504-6 | Aline de Moura Brasil Matos | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-025-10504-6 | Patients with neurocovid exhibited a higher susceptibility to adverse outcomes compared to other COVID-19 patients. Among all neurological syndromes, vascular syndromes were the most common, and their severity surpassed that of vascular syndromes not attributed to COVID-19. Patients were 10 times more likely to die (OR = 10.89) and 38 times more likely to be hospitalized than other COVID-19 patients (OR = 38.22). Those developing vascular syndromes patients were 3 times more likely to require ICU (OR = 3.78) and 4 times more likely to die (OR = 4.73) than patients with vascular syndromes due to different etiologies. | |||||||||||||||||||||
396 | Severe central nervous system injury in 9 children with COVID-19 | 2025-01-27 | https://doi.org/10.1186/s12887-025-05436-8 | Peipei Zhang | https://link.springer.com/article/10.1186/s12887-025-05436-8 | COVID-19 can cause severe damage to the CNS in pediatric patients. Severe CNS (central nervous system) injury caused by COVID-19 has an acute onset, rapid progression, high disability rate, and high fatality rate. | |||||||||||||||||||||
397 | Novel brain SPECT imaging unravels abnormal cerebral perfusion in patients with postural orthostatic tachycardia syndrome and cognitive dysfunction | 2025-01-28 | https://doi.org/10.1038/s41598-025-87748-4 | Marie-Claire Seeley | https://www.nature.com/articles/s41598-025-87748-4 | There is a high prevalence of reduced cerebral perfusion in those with POTS, which is detectable with supine brain SPECT imaging and is associated with diminished quality of life. A discernible trigger with temporal proximity to POTS symptom onset was found in 71% of the cohort. SARS-CoV-2 infection was the most common of these (29%). All had laboratory confirmed mild COVID-19 infection that did not require hospitalization or oxygen therapy. | |||||||||||||||||||||
398 | Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection | 2025-01-30 | https://doi.org/10.1038/s41591-024-03426-4 | Eugene P. Duff | https://www.nature.com/articles/s41591-024-03426-4 | Our data from this post hoc case–control matched study thus provide observational biomarker evidence that SARS-CoV-2 infection can be associated with greater brain β-amyloid pathology in older adults. While these results do not establish causality, they suggest that SARS-CoV-2 (and possibly other systemic inflammatory diseases) may increase the risk of future Alzheimer’s disease. | |||||||||||||||||||||
399 | Executive functioning in subjects post COVID-19 infection in Mexico | 2025-01-31 | https://doi.org/10.1080/23279095.2025.2458684 | Adriana Aguayo Arelis | Individuals who have recovered from mild COVID-19 do not display widespread impairments in executive functions, with the exception of deficits observed on the M-WCST. This suggests possible neurophysiological alterations in the prefrontal cortex during SARS-CoV-2 infection. | ||||||||||||||||||||||
400 | Assessment of Autonomic Nervous System Function in Patients with Chronic Fatigue Syndrome and Post-COVID-19 Syndrome Presenting with Recurrent Syncope | 2025-01-26 | https://doi.org/10.3390/jcm14030811 | PMC11818862 | Branislav Milovanovic | https://pmc.ncbi.nlm.nih.gov/articles/PMC11818862/ | Both chronic fatigue syndrome groups demonstrated significant autonomic nervous system dysfunction compared to healthy controls (p < 0.05), including reduced baroreceptor sensitivity and impaired heart rate variability parameters. Syncope prevalence was high in both chronic fatigue syndrome groups, with extreme blood pressure variability observed in 45–47% of patients during the head-up tilt test. Patients with post-COVID-19 chronic fatigue syndrome exhibited greater blood pressure increases during the head-up tilt test than those with chronic fatigue syndrome of unknown etiology (p < 0.05). | ||||||||||||||||||||
401 | Decreases in frequency-dependent intrinsic activity of the default mode network are associated with depression and cognition in patients with postacute sequelae of SARS-CoV-2 infection | 2025-01-27 | https://doi.org/10.1007/s00429-025-02895-8 | Yao Wang | https://link.springer.com/article/10.1007/s00429-025-02895-8 | Significant frequency-dependent alterations in intrinsic activity patterns were observed in both the PASC and non-PASC groups, primarily involving regions of the default mode network (DMN). Our results may provide insights into the potential neural mechanisms underlying symptoms in PASC patients. | |||||||||||||||||||||
402 | Long COVID affects working memory: Assessment using a single rapid online test | 2025-01-28 | https://doi.org/10.1101/2025.01.26.25321152 | Aziz UR Asghar | https://www.medrxiv.org/content/10.1101/2025.01.26.25321152v1 | Long COVID is associated with significant working memory impairments. The results demonstrate that long COVID significantly impairs working memory, with the greatest deficits observed in clinically diagnosed cases. | |||||||||||||||||||||
403 | Two-year impact of COVID-19: Longitudinal MRI brain changes and neuropsychiatric trajectories | 2025-02-04 | https://doi.org/10.1111/pcn.13789 | Ravi Dadsena | https://onlinelibrary.wiley.com/doi/10.1111/pcn.13789 | Our findings indicate that complex brain adaptations take place up to 2 years following SARS-CoV-2 infection. In post-COVID patients 23 months after SARS-CoV-2 infection we observed (1) that fatigue severity had reduced but still remained present in most patients, (2) widespread brain changes involving the brainstem, the pre- and postcentral gyrus and the limbic olfactory network, (3) a weakening of self-reported fatigue and its cerebral associations. | |||||||||||||||||||||
404 | Chronic autonomic symptom burden in long-COVID: a follow-up cohort study | 2025-02-05 | https://doi.org/10.1007/s10286-025-01111-1 | Ella F. Eastin | https://link.springer.com/article/10.1007/s10286-025-01111-1 | Evidence of chronic moderate-to-severe autonomic dysfunction was seen in most participants with LC in our cohort and was significantly associated with reduced quality of life and functional disability. The median symptom duration was 36 [30–40] months, and 37.5% of participants could no longer work or had to drop out of school due to their illness. In addition, 40.5% of individuals with autonomic dysfunction were newly diagnosed with POTS, representing 33% of the total LC cohort. | |||||||||||||||||||||
405 | Status and risk factors for depression, anxiety, and insomnia symptoms among adolescents in the post-pandemic era | 2025-02-05 | https://doi.org/10.1186/s12889-025-21650-6 | PMC11800650 | Xing-Jie Yang | https://pmc.ncbi.nlm.nih.gov/articles/PMC11800650/ | COVID-19 exposure was closely related to mental health status in adolescents. Adolescents who had COVID-19 showed more severe depression, anxiety, and sleep problems than those who did not. COVID-19 survivors experienced fatigue and cognitive issues, including concentration problems, memory loss, and impaired verbal fluency, executive functions, and psychomotor coordination. | ||||||||||||||||||||
406 | Prospective Follow-Up of Neurological Findings and Recovery Tımes in COVID-19 Patients | 2025-02-08 | https://doi.org/10.3390/covid5020019 | Mirkan Bulğak | https://www.mdpi.com/2673-8112/5/2/19 | Neurological symptoms, such as fatigue, headache, myalgia, and forgetfulness, were prevalent in both the acute and post-COVID-19 phases. Fatigue (75.5%) was the most common symptom, lasting 10.43 weeks on average, followed by myalgia (57.3%, 4.29 weeks) and headache (56.4%, 3.35 weeks). Forgetfulness persisted the longest (22.03 weeks). | |||||||||||||||||||||
407 | SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection | 2025-02-08 | https://doi.org/10.1101/2025.02.07.637145 | Simon De Neck | https://www.biorxiv.org/content/10.1101/2025.02.07.637145v1 | SARS-CoV-2 infection of the neurons induces neuroinflammation, with leukocyte recruitment and activation as well as blood-brain barrier dysfunction. | |||||||||||||||||||||
408 | Structural brain changes in post-COVID condition and its relationship with cognitive impairment | 2025-02-12 | https://doi.org/10.1093/braincomms/fcaf070 | Laura Pacheco-Jaime | https://academic.oup.com/braincomms/article/7/1/fcaf070/8010560?login=false | Our study identified structural brain alterations implying increased CTh (cortical thickness) and abnormal microstructural WM (white matter) integrity, and worse cognitive performance across various cognitive domains in post-COVID condition patients almost 2 years after COVID infection. Changes in CTh are associated with clinically meaningful cognitive impairment while WM changes are related with subjective memory failures. | |||||||||||||||||||||
409 | Are Neurocognitive Deficits Associated With Gastrointestinal Symptoms in Children due to COVID-19? | 2025-02-13 | https://doi.org/10.1002/jdn.70007 | Kalliopi Megari | https://onlinelibrary.wiley.com/doi/10.1002/jdn.70007 | We found that there was a significant relationship between cognitive function and GI symptoms, as well as between cognitive function and the severity of these symptoms. This indicates that COVID-19 patients with GI symptoms may be at risk for developing problems with their memory and other aspects of cognition. | |||||||||||||||||||||
410 | Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital | 2025-02-14 | https://doi.org/10.1007/s10072-025-08031-y | Oriol Barrachina-Esteve | https://link.springer.com/article/10.1007/s10072-025-08031-y | Of the 62 patients who underwent neuropsychological examination 3 months after discharge, 22.6% had impaired attention, 19.4% impaired working memory, 16.1% impaired learning and retrieval, 9.7% impaired executive functions, and 8.2% impaired processing speed. At follow-up 12 months after hospital discharge, 14.3% of patients still showed impaired attention, 2.4% impaired working memory, 2.5% impaired executive functions, and 2.5% impaired processing speed. | |||||||||||||||||||||
411 | Correlation between changes of sleep quality and brain functional connectivity patterns in COVID-19 patients: A three-month longitudinal cohort study | 2025-02-15 | https://doi.org/10.1016/j.sleep.2025.02.016 | Bei Peng | https://www.sciencedirect.com/science/article/abs/pii/S138994572500067X | Changes in sleep quality following COVID-19 infection are associated with brain functional connectivity patterns. Decreased Eglob (global efficiency) is related to worsened sleep quality. Abnormal brain functional connectivity is a defining feature in post-COVID-19 patients with insomnia, with the FPN (frontoparietal network) emerging as a potential target for neuromodulation therapy, | |||||||||||||||||||||
412 | Long COVID Psychiatric Sequelae, Biochemical Markers & Tau Protein: A 3-Year Follow-Up Study | 2025-02-19 | https://doi.org/10.1016/j.psychres.2025.116413 | Shivani Jaiswal | https://www.sciencedirect.com/science/article/abs/pii/S0165178125000629 | COVID-19 survivors with a history of severe infection displayed higher p-tau and HbA1c levels, indicating potential new-onset diabetes and neuronal damage. Electrolyte imbalances, particularly sodium, potassium, and calcium, during acute infection predicted long-term psychiatric symptoms, including depression, anxiety, and somatization. | |||||||||||||||||||||
413 | Perivascular spaces in neuropsychiatric post-COVID syndrome | 2025-02-21 | https://doi.org/10.21203/rs.3.rs-6042521/v1 | Jose Bernal | https://www.researchsquare.com/article/rs-6042521/v1 | In individuals with a neuropsychiatric post-COVID syndrome, longer duration of the neuropsychiatric symptoms was associated with larger fractional PVS (perivascular spaces) volumes. The presence and duration of neuropsychiatric post-COVID syndrome in humans relate to the extent of enlargement of PVS in the brain. | |||||||||||||||||||||
414 | The impact of long COVID on heart rate variability: a cross-sectional study | 2025-02-24 | https://doi.org/10.1186/s12879-024-10361-9 | Minyu Qin | https://link.springer.com/article/10.1186/s12879-024-10361-9 | Young patients (ages 18–25) with LC show signs of autonomic nervous system dysfunction four weeks post-infection. Compared to the group without LC, a higher number of people in the LC group had aberrant autonomic neuroactivity (p = 0.048). | |||||||||||||||||||||
415 | The Effects of Covid-19 “brain Fog” on Electrophysiological Measures of Attention and Working Memory: a P300 Study | 2025-02-27 | https://doi.org/10.21203/rs.3.rs-5890007/v1 | MATTHEW J. WILSON | https://www.researchsquare.com/article/rs-5890007/v1 | Regardless of cognitive load, individuals with a history of COVID-19 related brain fog displayed overall smaller P300 amplitudes relative to those without brain fog and pre-pandemic controls. This result suggests the development of brain fog reduces the availability of attentional resources even in the absence of active symptoms. Behavioral accuracy, reaction time, or neurocognitive testing did not differ by group, implying that the development of COVID-19 related brain fog may influence neurophysiological processing that may persist even after initial symptoms subside. |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 798 | |||||||||||||||||||||||||
3 | Persistent Symptoms in Patients After Acute COVID-19 | 2020-07-09 | https://doi.org/10.1001/jama.2020.12603 | Angelo Carfì | https://jamanetwork.com/journals/jama/fullarticle/2768351 | Patients were assessed a mean of 60.3 (SD, 13.6) days after onset of the first COVID-19 symptom; at the time of the evaluation, only 18 (12.6%) were completely free of any COVID-19–related symptom, while 32% had 1 or 2 symptoms and 55% had 3 or more. Worsened quality of life was observed among 44.1% of patients. The Figure shows that a high proportion of individuals still reported fatigue (53.1%), dyspnea (43.4%), joint pain, (27.3%) and chest pain (21.7%). | |||||||||||||||||||||
4 | Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19 | 2020-07-20 | https://doi.org/10.1136/gutjnl-2020-322294 | Tao Zuo | https://gut.bmj.com/content/70/2/276.info | We found for the first time a signature of active gut viral infection in a subset (47%) of patients with COVID-19 even in the absence of GI symptoms, suggesting ‘quiescent’ GI infection of SARS-CoV-2. The transcriptional activity of viral infection and replication persisted in the gut even after respiratory clearance of SARS-CoV-2. Faecal samples with a signature of high SARS-CoV-2 infectivity harboured a higher abundance of opportunistic pathogens | |||||||||||||||||||||
5 | 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study | 2021-01-16 | https://doi.org/10.1016/S0140-6736(20)32656-8 | Chaolin Huang MD | https://www.sciencedirect.com/science/article/pii/S0140673620326568 | At 6 months after acute infection, COVID-19 survivors were mainly troubled with fatigue or muscle weakness, sleep difficulties, and anxiety or depression. Patients who were more severely ill during their hospital stay had more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations. | |||||||||||||||||||||
6 | Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge | 2021-01-27 | 10.1001/jamanetworkopen.2020.36142 | Mattia Bellan | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775643 | In this cohort study of 238 patients with COVID-19 hospitalized in an academic hospital in Northern Italy, more than half of participants had a significant reduction of diffusing lung capacity for carbon monoxide or measurable functional impairment and approximately one-fifth of patients had symptoms of posttraumatic stress 4 months after discharge. | |||||||||||||||||||||
7 | Muscle Strength and Physical Performance in Patients Without Previous Disabilities Recovering From COVID-19 Pneumonia | 2021-02-01 | https://doi.org/10.1097/phm.0000000000001641 | Mara Paneroni | https://pubmed.ncbi.nlm.nih.gov/33181531/ | The high prevalence of impairment in skeletal muscle strength and physical performance in hospitalized patients recovering from COVID-19 pneumonia without previous locomotor disabilities suggests the need for rehabilitation programs after discharge. Quadriceps and biceps were weak in 86% and 73% of the patients, respectively. Maximal voluntary contraction for quadriceps was 18.9 (6.8) kg and for biceps 15.0 (5.5) kg (i.e., 54% and 69% of the predicted normal value, respectively). The number of chair rises in the 1-min sit-to-stand test was 22.1 (7.3 corresponding to 63% of the predicted normal value), whereas the short physical performance battery score was 7.9 (3.3 corresponding to 74% of the predicted normal value). | |||||||||||||||||||||
8 | Sequelae in Adults at 6 Months After COVID-19 Infection | 2021-02-19 | doi:10.1001/jamanetworkopen.2021.0830 | Jennifer K. Logue | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2776560 | In this cohort of individuals with COVID-19 who were followed up for as long as 9 months after illness, approximately 30% reported persistent symptoms. Persistent symptoms were reported by one-third of outpatients in our study, consistent with a previously reported study, in which 36% of outpatients had not returned to baseline health by 14 to 21 days following infection. | |||||||||||||||||||||
9 | COVID-19 and male reproductive function: a prospective, longitudinal cohort study | 2021-03-01 | https://doi.org/10.1530/REP-20-0382 | Behzad Hajizadeh Maleki | https://rep.bioscientifica.com/view/journals/rep/161/3/REP-20-0382.xml | These perturbations tended to persist over time and were correlated with significant impairments in semen volume, progressive motility, sperm morphology, sperm concentration, and the number of spermatozoa. We provide the direct experimental evidence that the male reproductive system could be targeted and damaged by the COVID-19 infection. | |||||||||||||||||||||
10 | Prolonged elevation of D-dimer levels in convalescent COVID-19 patients is independent of the acute phase response | 2021-03-08 | https://doi.org/10.1111/jth.15267 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8013297/ | Liam Townsend | https://www.jthjournal.org/article/S1538-7836(22)00737-1/fulltext | In conclusion, our findings clearly demonstrate that elevation in D‐dimers is a common finding in COVID‐19 patients during convalescence. Importantly, this increase in D‐dimer was seen at a median of greater than 2 months following resolution of acute COVID‐19 infection and was observed in a cohort comprising predominantly young patients (median age 47 years) who mostly (64%) recovered without hospitalization. | ||||||||||||||||||||
11 | Exploring causal relationships between COVID-19 and cardiometabolic disorders: A bi-directional Mendelian randomization study | 2021-03-20 | https://doi.org/10.1101/2021.03.20.21254008 | Yong Xiang | https://www.medrxiv.org/content/10.1101/2021.03.20.21254008v1 | Overall we observed evidence that liability to COVID-19 or severe infection may be causally associated with higher risks of type 2 diabetes mellitus(T2DM), chronic kidney disease(CKD), ischemic stroke (especially large artery stroke[LAS]) and heart failure(HF) when compared to the general population. | |||||||||||||||||||||
12 | Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study | 2021-03-30 | 10.1136/bmjopen-2020-048391 | Andrea Dennis | https://bmjopen.bmj.com/content/11/3/e048391 | In individuals at low risk of COVID-19 mortality with ongoing symptoms, 70% have impairment in one or more organs 4 months after initial COVID-19 symptoms, with implications for healthcare and public health, which have assumed low risk in young people with no comorbidities. | |||||||||||||||||||||
13 | Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study | 2021-03-31 | https://doi.org/10.1136/bmj.n693 | Daniel Ayoubkhani | https://www.bmj.com/content/372/bmj.n693 | Individuals discharged from hospital after covid-19 had increased rates of multiorgan dysfunction compared with the expected risk in the general population. The increase in risk was not confined to the elderly and was not uniform across ethnicities. Over a mean follow-up of 140 days, nearly a third of individuals who were discharged from hospital after acute covid-19 were readmitted (14 060 of 47 780) and more than 1 in 10 (5875) died after discharge, with these events occurring at rates four and eight times greater, respectively, than in the matched control group. | |||||||||||||||||||||
14 | High-dimensional characterization of post-acute sequelae of COVID-19 | 2021-04-22 | https://doi.org/10.1038/s41586-021-03553-9 | Ziyad Al-Aly | https://www.nature.com/articles/s41586-021-03553-9 | We show that beyond the first 30 days of illness, people with COVID-19 exhibit a higher risk of death and use of health resources. Our findings show that a substantial burden of health loss that spans pulmonary and several extrapulmonary organ systems is experienced by patients who survive after the acute phase of COVID-19. | |||||||||||||||||||||
15 | SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment | 2021-05-18 | https://doi.org/10.1016/j.cmet.2021.05.013 | Chien-Ting Wu | https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00230-8 | We discovered that SARS-CoV-2 infects human pancreatic β cells in patients who succumbed to COVID-19 and selectively infects human islet β cells in vitro. We demonstrated that SARS-CoV-2 infection attenuates pancreatic insulin levels and secretion and induces β cell apoptosis, each rescued by NRP1 inhibition. Phosphoproteomic pathway analysis of infected islets indicates apoptotic β cell signaling, similar to that observed in type 1 diabetes (T1D). In summary, our study shows SARS-CoV-2 can directly induce β cell killing. | |||||||||||||||||||||
16 | Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study | 2021-05-19 | https://doi.org/10.1136/bmj.n1098 | Sarah E Daugherty | https://www.bmj.com/content/373/bmj.n1098 | 14% of adults aged ≤65 who were infected with SARS-CoV-2 (27 074 of 193 113) had at least one new type of clinical sequelae that required medical care after the acute phase of the illness, which was 4.95% higher than in the 2020 comparator group. The risk for specific new sequelae attributable to SARS-Cov-2 infection after the acute phase, including chronic respiratory failure, cardiac arrythmia, hypercoagulability, encephalopathy, peripheral neuropathy, amnesia (memory difficulty), diabetes, liver test abnormalities, myocarditis, anxiety, and fatigue, was significantly greater than in the three comparator groups (2020, 2019, and viral lower respiratory tract illness groups) (all P<0.001). | |||||||||||||||||||||
17 | Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members | 2021-05-24 | https://doi.org/10.1183/23120541.00141-2021 | Anouk W. Vaes | https://publications.ersnet.org/content/erjor/7/2/00141-2021 | Approximately 6 months after the onset of COVID-19-related symptoms a large proportion still experienced persistent symptoms, a moderate-to-poor health, moderate-to-severe functional limitations, considerable loss in work productivity, and/or an impaired quality of life. Patients also reported a significantly improved work productivity (work absenteeism and presenteeism: 73% versus 52% and 66% versus 60%, respectively), self-reported good health (9.2% versus 16.7%), functional status (mean±sd Post-COVID-19 Functional Status scale: 2.4±0.9 versus 2.2±1.0) and health-related quality of life (all p<0.05). | |||||||||||||||||||||
18 | Sequelae in adults at 12 months after mild-to-moderate coronavirus disease 2019 (COVID-19) | 2021-06-09 | https://doi.org/10.1002/alr.22832 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9291310/ | Paolo Boscolo-Rizzo | https://pmc.ncbi.nlm.nih.gov/articles/PMC9291310/ | Our study indicates that persistent symptoms of SARS‐CoV‐2 infection can be detected beyond 12 months from the onset of the illness in more than half of outpatients. Twelve months after the onset of illness, 53.0% of patients with mild‐to‐moderate disease endorsed at least one persistent symptom. | ||||||||||||||||||||
19 | Persistence of symptoms after improvement of acute COVID19 infection, a longitudinal study | 2021-06-25 | https://doi.org/10.1002/jmv.27156 | Mona Mohammed Abdelrahman | https://onlinelibrary.wiley.com/doi/10.1002/jmv.27156 | There was a high percentage of patients who complained of persistent symptoms after recovery from COVID-19. After recovery, 105 patients (61%) (30 male, 75 female) reported one or more COVID-19 persistent symptoms. Fatigue, dyspnea, and depression were the most common persistent symptoms representing 37.3%, 22%, 22%, respectivel | |||||||||||||||||||||
20 | Long-Term Outcomes of Patients with Coronavirus Disease 2019 at One Year after Hospital Discharge | 2021-06-30 | https://doi.org/10.3390/jcm10132945 | Modesto M. Maestre-Muñiz | https://www.mdpi.com/2077-0383/10/13/2945 | One-year mortality among survivors of acute COVID-19 was 7.5%. A significant proportion of COVID-19 patients experienced ongoing symptoms at 1 year from onset of the disease. Ongoing symptoms attributed to COVID-19 were reported by 66.8% and 49.5% of patients, respectively (p < 0.001). Newly developed COPD, asthma, diabetes, heart failure, and arthritis—as well as worsening of preexisting comorbidities—were found. | |||||||||||||||||||||
21 | Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis | 2021-07-01 | https://doi.org/10.1016/j.pulmoe.2020.10.013 | R. Torres-Castro | https://www.sciencedirect.com/science/article/pii/S2531043720302452?via%3Dihub | Post-infection COVID-19 patients showed impaired lung function; the most important of the pulmonary function tests affected was the diffusion capacity. We found a prevalence of 0.39 (CI 0.24–0.56, p < 0.01, I2 = 86%), 0.15 (CI 0.09–0.22, p = 0.03, I2 = 59%), and 0.07 (CI 0.04–0.11, p = 0.31, I2 = 16%) for altered diffusion capacity of the lungs for carbon monoxide (DLCO), restrictive pattern and obstructive pattern, respectively. | |||||||||||||||||||||
22 | Characterizing long COVID in an international cohort: 7 months of symptoms and their impact | 2021-07-15 | https://doi.org/10.1016/j.eclinm.2021.101019 | Hannah E. Davis | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00299-6/fulltext | Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.1700 respondents (45.2%) required a reduced work schedule compared to pre-illness, and an additional 839 (22.3%) were not working at the time of survey due to illness. Cognitive dysfunction or memory issues were common across all age groups (~88%). | |||||||||||||||||||||
23 | One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms | 2021-07-27 | https://doi.org/10.3390/jcm10153305 | Andreas Rank | https://www.mdpi.com/2077-0383/10/15/3305 | Persistent complications, including headache, concentration difficulties and loss of smell/taste, were reported by 51 of 83 (61%) participants and decreased over time to 28% one year after COVID-19. | |||||||||||||||||||||
24 | Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19 | 2021-08-05 | https://doi.org/10.1111/cea.13997 | Daniel Munblit | https://onlinelibrary.wiley.com/doi/10.1111/cea.13997 | Almost half of adults admitted to hospital due to COVID-19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. | |||||||||||||||||||||
25 | Twelve-Month Systemic Consequences of Coronavirus Disease 2019 (COVID-19) in Patients Discharged From Hospital: A Prospective Cohort Study in Wuhan, China | 2021-08-14 | https://doi.org/10.1093/cid/ciab703 | Tingting Liu | https://academic.oup.com/cid/article/74/11/1953/6352408 | Physiological, laboratory, radiological, or electrocardiogram abnormalities, particularly those related to renal, cardiovascular, and liver functions are common in patients who recovered from coronavirus disease 2019 (COVID-19) up to 12 months post-discharge. 257 (51.2%) patients had at least one symptom at 3 months post-discharge, which decreased to 169 (40.0%) and 138 (28.4%) at 6-month and 12-month visit respectively. | |||||||||||||||||||||
26 | Clinical Characteristics and the Long-Term Post-recovery Manifestations of the COVID-19 Patients—A Prospective Multicenter Cross-Sectional Study | 2021-08-16 | https://doi.org/10.3389/fmed.2021.663670 | Abu Taiub Mohammed Mohiuddin Chowdhury | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.663670/full | The post-COVID-19 persisting symptoms/complaints were found among 21.4% of symptomatic patients, which persisted for ≥20 weeks and had a significant relationship with the duration of COVID-19 illness and the existing comorbidity (p < 0.05). Post-COVID-19 primary type 2 diabetes mellitus (DM, 0.64%) and hypertension (HTN, 1.28%) and unstable DM (54.55%) and HTN (34.78%) to the pre-existing diabetic and hypertensive patients were observed. | |||||||||||||||||||||
27 | 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study | 2021-08-28 | https://doi.org/10.1016/s0140-6736(21)01755-4 | 34454673 | Lixue Huang | https://pubmed.ncbi.nlm.nih.gov/34454673/ | The health status in our cohort of COVID-19 survivors at 12 months was still lower than that in the control population. The proportion of patients with at least one sequelae symptom decreased from 68% (831/1227) at 6 months to 49% (620/1272) at 12 months (p<0·0001). The proportion of patients with dyspnoea, characterised by mMRC score of 1 or more, slightly increased from 26% (313/1185) at 6-month visit to 30% (380/1271) at 12-month visit (p=0·014). Additionally, more patients had anxiety or depression at 12-month visit (26% [331/1271] at 12-month visit vs 23% [274/1187] at 6-month visit; p=0·015). | ||||||||||||||||||||
28 | Kidney Outcomes in Long COVID | 2021-09-01 | https://doi.org/10.1681/asn.2021060734 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8806085/ | Benjamin Bowe | https://pubmed.ncbi.nlm.nih.gov/34470828/ | Patients who survived COVID-19 exhibited increased risk of kidney outcomes in the post-acute phase of the disease. Compared with non-infected controls, 30-day survivors of COVID-19 exhibited excess eGFR decline (95% CI) of -3.26 (-3.58 to -2.94), -5.20 (-6.24 to -4.16), and -7.69 (-8.27 to -7.12) ml/min per 1.73 m2 per year, respectively, in non-hospitalized, hospitalized, and those admitted to intensive care during the acute phase of COVID-19 infection. (eGFR is estimated glomerular filtration rate, is a measure of how well your kidneys are working.) | ||||||||||||||||||||
29 | Follow-up study on COVID-19 survivors one year after discharge from hospital | 2021-09-11 | https://doi.org/10.1016/j.ijid.2021.09.017 | Yumiao Zhao | https://www.ijidonline.com/article/S1201-9712(21)00726-8/fulltext | One year after hospitalization for COVID-19, a cohort of survivors were mainly troubled with muscle fatigue and insomnia. Pulmonary structural abnormalities and pulmonary diffusion capacities were highly prevalent in surviving COVID-19 patients. Chest CT scans were abnormal in 71.28% of participants. | |||||||||||||||||||||
30 | Persistent endotheliopathy in the pathogenesis of long COVID syndrome | 2021-09-12 | https://doi.org/10.1111/jth.15490 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8420256/ | Helen Fogarty | https://pubmed.ncbi.nlm.nih.gov/34375505/ | Collectively, our findings demonstrate that sustained endotheliopathy is common in convalescent COVID-19 and raise the intriguing possibility that this may contribute to long COVID pathogenesis.Thrombin generation assays revealed significantly shorter lag times, increased endogenous thrombin potential, and peak thrombin in convalescent COVID-19 patients. | ||||||||||||||||||||
31 | Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19 | 2021-09-28 | https://doi.org/10.1371/journal.pmed.1003773 | Maxime Taquet | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003773 | The research found that over 1 in 3 patients had one or more features of long-COVID recorded between 3 and 6 months after a diagnosis of COVID-19. This was significantly higher than after influenza. For 2 in 5 of the patients who had long-COVID features in the 3- to 6-month period, they had no record of any such feature in the previous 3 months. | |||||||||||||||||||||
32 | Osteoclast-mediated bone loss observed in a COVID-19 mouse model | 2021-10-02 | https://doi.org/10.1016/j.bone.2021.116227 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8486589/ | Olatundun D Awosanya | https://pubmed.ncbi.nlm.nih.gov/34607050/ | this study demonstrates a significant reduction in several bone parameters and corresponding robust increases in osteoclast number observed within 2 weeks post-infection in surviving asymptomatic and moderately affected mice | ||||||||||||||||||||
33 | Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study | 2021-10-07 | https://doi.org/10.1016/S2213-2600(21)00383-0 | Rachael A Evans | https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00383-0/fulltext | At follow-up, only 239 (29%) of 830 participants felt fully recovered, 158 (20%) of 806 had a new disability (assessed by the Washington Group Short Set on Functioning), and 124 (19%) of 641 experienced a health-related change in occupation. Three (3%) of 113 patients in the very severe cluster, nine (7%) of 129 in the severe cluster, 36 (36%) of 99 in the moderate cluster, and 114 (43%) of 267 in the mild cluster reported feeling fully recovered. | |||||||||||||||||||||
34 | Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study | 2021-10-21 | https://doi.org/10.1016/j.rmed.2021.106665 | Lorenzo Gamberini | https://www.resmedjournal.com/article/S0954-6111(21)00373-5/fulltext | HRQoL impairment is frequent 1 year after ICU discharge, and the lowest recovery is found in the mental dimensions. Persistent dyspnea is often reported and weakly correlated with PFTs (pulmonary function tests) alterations.We found that HRQoL increased during the study period, especially for the significant increase of the physical dimensions, while the mental dimensions and dyspnea remained substantially unchanged. Four main 15D profiles were identified: full recovery (47.2%), bad recovery (5.1%) and two partial recovery clusters with mostly physical (9.6%) or mental (38.2%) dimensions affected. | |||||||||||||||||||||
35 | Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction | 2021-10-29 | https://doi.org/10.1038/s43856-021-00044-w | Minjin Jeong | https://www.nature.com/articles/s43856-021-00044-w | Hair cells and Schwann cells in explanted human vestibular tissue can be infected by SARS-CoV-2, as demonstrated by confocal microscopy. The inner ear organoids show that hair cells express ACE2 and are targets for SARS-CoV-2. | |||||||||||||||||||||
36 | Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection | 2021-10-13 | doi:10.1001/jamanetworkopen.2021.28568 | Destin Groff | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2784918 | More than half of COVID-19 survivors experienced PASC 6 months after recovery. The most common PASC involved functional mobility impairments, pulmonary abnormalities, and mental health disorders. The median (IQR) proportion of COVID-19 survivors experiencing at least 1 PASC was 54.0% (45.0%-69.0%; 13 studies) at 1 month (short-term), 55.0% (34.8%-65.5%; 38 studies) at 2 to 5 months (intermediate-term), and 54.0% (31.0%-67.0%; 9 studies) at 6 or more months (long-term). | |||||||||||||||||||||
37 | Limited recovery from post-acute sequelae of SARS-CoV-2 at 8 months in a prospective cohort | 2021-11-01 | https://doi.org/10.1183%2F23120541.00384-2021 | PMC8504133 | David Ross Darley | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504133/ | In a longitudinal cohort, a significant proportion of patients had persistent symptoms 8 months after initial #COVID19 infection. There was no significant improvement in symptoms or health-related quality of life between 4- and 8-month assessments. | ||||||||||||||||||||
38 | Epigenome-wide DNA methylation profiling of healthy COVID-19 recoverees reveals a unique signature in circulating immune cells | 2021-11-08 | https://doi.org/10.1101/2021.07.05.21260014 | Johanna Huoman | https://www.medrxiv.org/content/10.1101/2021.07.05.21260014v2 | Altered DNA methylation patterns of COVID-19 convalescents suggest recovery from mild-to-moderate SARS-CoV-2 infection leaves longstanding epigenetic traces. | |||||||||||||||||||||
39 | High prevalence of long-term olfactory, gustatory, and chemesthesis dysfunction in post-COVID-19 patients: a matched case-control study with one-year follow-up using a comprehensive psychophysical evaluation | 2021-12-01 | https://doi.org/10.4193/rhin21.249 | P Boscolo-Rizzo | https://pubmed.ncbi.nlm.nih.gov/34553706/ | More than one year after the onset of COVID-19, cases exhibited an excess of olfactory, gustatory , and chemesthesis disturbances compared to matched-pair controls with these symptoms being associated to emotional distress and depression. The evaluation of orthonasal smell identified 46% and 10% of cases and controls, respectively, having olfactory dysfunction, with 7% of COVID-19 cases being functionally anosmic. Testing of gustatory function revealed a 27% of cases versus 10% of controls showing a gustatory impairment. | |||||||||||||||||||||
40 | COVID-19 Infection Is Associated With New Onset Erectile Dysfunction: Insights From a National Registry | 2021-12-15 | https://doi.org/10.1016/j.esxm.2021.100478 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8673874/ | Kevin Y Chu | https://pubmed.ncbi.nlm.nih.gov/34931145/#affiliation-2 | we compared 230,517 men with COVID-19 to 232,645 men without COVID-19 and found that COVID-19 diagnosis was significantly associated with ED (odds ratio 1.20, 95% confidence interval 1.004-1.248, P= .04). | ||||||||||||||||||||
41 | Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study | 2022-01-13 | https://doi.org/10.1093%2Fptj%2Fpzac005 | https://pubmed.ncbi.nlm.nih.gov/35079817 | Rosie Twomey | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383197/ | 71.4% were experiencing chronic fatigue. Postexertional symptom exacerbation affected most participants, and 58.7% met the PEM (postexertional malaise) scoring thresholds used in people living with myalgic encephalomyelitis/chronic fatigue syndrome. | ||||||||||||||||||||
42 | Risk for Newly Diagnosed Diabetes >30 Days After SARS-CoV-2 Infection Among Persons Aged <18 Years — United States, March 1, 2020–June 28, 2021 | 2022-01-14 | http://dx.doi.org/10.15585/mmwr.mm7102e2 | Catherine E. Barrett | https://www.cdc.gov/mmwr/volumes/71/wr/mm7102e2.htm?s_cid=mm7102e2_w | New diabetes diagnoses were 166% (IQVIA) and 31% (HealthVerity) more likely to occur among patients with COVID-19 than among those without COVID-19 during the pandemic and 116% more likely to occur among those with COVID-19 than among those with ARI during the prepandemic period. Non–SARS-CoV-2 respiratory infection was not associated with diabetes. | |||||||||||||||||||||
43 | SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response | 2022-01-25 | https://doi.org/10.1038/s43587-022-00170-7 | Shunya Tsuji | https://www.nature.com/articles/s43587-022-00170-7 | The sustained infection-induced paracrine senescence (biological aging of adjacent cells) described here may be involved in the long-term inflammation caused by SARS-CoV-2 infection. We find that mice exposed to a mouse-adapted strain of SARS-CoV-2 exhibit prolonged signs of cellular senescence and SASP in the lung at 14 days after infection when the virus was undetectable | |||||||||||||||||||||
44 | Risk of persistent and new clinical sequelae among adults aged 65 years and older during the post-acute phase of SARS-CoV-2 infection: retrospective cohort study | 2022-02-09 | https://doi.org/10.1136/bmj-2021-068414 | Ken Cohen | https://www.bmj.com/content/376/bmj-2021-068414 | The results confirm an excess risk for persistent and new sequelae in adults aged ≥65 years after acute infection with SARS-CoV-2. Other than respiratory failure, dementia, and post-viral fatigue, the sequelae resembled those of viral lower respiratory tract illness in older adults. Respiratory failure (risk difference 7.55, 95% confidence interval 7.18 to 8.01), fatigue (5.66, 5.03 to 6.27), hypertension (4.43, 2.27 to 6.37), memory difficulties (2.63, 2.23 to 3.13), kidney injury (2.59, 2.03 to 3.12), mental health diagnoses (2.50, 2.04 to 3.04), hypercoagulability 1.47 (1.2 to 1.73), and cardiac rhythm disorders (2.19, 1.76 to 2.57) had the greatest risk differences compared with the 2020 comparison group. | |||||||||||||||||||||
45 | Tip of the iceberg: erectile dysfunction and COVID-19 | 2022-02-12 | https://doi.org/10.1038/s41443-022-00540-0 | Kaynar, M | https://www.nature.com/articles/s41443-022-00540-0#citeas | COVID-19 infection could affect male sexual function through endothelial damage in erectile tissue, testicular damage, and psychological alterations. | |||||||||||||||||||||
46 | Risks of mental health outcomes in people with covid-19: cohort study | 2022-02-16 | https://doi.org/10.1136/bmj-2021-068993 | Yan Xie | https://www.bmj.com/content/376/bmj-2021-068993 | The risk of incident mental health disorders was consistently higher in the covid-19 group in comparisons of people with covid-19 not admitted to hospital versus those not admitted to hospital for seasonal influenza, admitted to hospital with covid-19 versus admitted to hospital with seasonal influenza, and admitted to hospital with covid-19 versus admitted to hospital for any other cause.The covid-19 group showed an increased risk of incident anxiety disorders (hazard ratio 1.35 (95% confidence interval 1.30 to 1.39)), depressive disorders (1.39 (1.34 to 1.43)); and stress and adjustment disorders (1.38 (1.34 to 1.43)). | |||||||||||||||||||||
47 | Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study | 2022-03-16 | https://doi.org/10.1016/S2352-4642(22)00022-0 | Terence Stephenson | https://www.sciencedirect.com/science/article/pii/S2352464222000220 | At 3 months after testing, the most common symptoms among the test-positive group were tiredness (1196 [39·0%]), headache (710 [23·2%]), and shortness of breath (717 [23·4%]), and among the test-negative group were tiredness (911 [24·4%]), headache (530 [14·2%]), and other (unspecified; 590 [15·8%]). Latent class analysis identified two classes, characterised by few or multiple symptoms. The estimated probability of being in the multiple symptom class was 29·6% (95% CI 27·4–31·7) for the test-positive group and 19·3% (17·7–21·0) for the test-negative group (risk ratio 1·53; 95% CI 1·35–1·70). | |||||||||||||||||||||
48 | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Intranasal or Intratesticular Route Induces Testicular Damage | 2022-02-18 | https://doi.org/10.1093/cid/ciac142 | Can Li | https://academic.oup.com/cid/article/75/1/e974/6530400?login=false | SARS-CoV-2 can cause acute testicular damage with subsequent chronic asymmetric testicular atrophy and associated hormonal changes. | |||||||||||||||||||||
49 | Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms | 2022-02-19 | https://doi.org/10.3390/pathogens11020269 | Qing Han | https://www.mdpi.com/2076-0817/11/2/269 | This study demonstrated that a sizeable proportion of COVID-19 survivors still experience residual symptoms involving various body systems one year later. Fatigue/weakness (28%, 95% CI: 18–39), dyspnoea (18%, 95% CI: 13–24), arthromyalgia (26%, 95% CI: 8–44), depression (23%, 95% CI: 12–34), anxiety (22%, 95% CI: 15–29), memory loss (19%, 95% CI: 7–31), concentration difficulties (18%, 95% CI: 2–35), and insomnia (12%, 95% CI: 7–17) were the most prevalent symptoms at one-year follow-up. | |||||||||||||||||||||
50 | Semen Proteomics of COVID-19 Convalescent Men Reveals Disruption of Key Biological Pathways Relevant to Male Reproductive Function | 2022-03-07 | https://doi.org/10.1021%2Facsomega.1c06551 | Susmita Ghosh | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928495/ | The major pathways involved in reproductive functions, such as sperm–oocyte recognition, testosterone response, cell motility regulation, adhesion regulation, extracellular matrix adhesion, and endopeptidase activity, were downregulated in COVID-19-recovered patients. Furthermore, the targeted approach revealed significant downregulation of semenogelin 1 and prosaposin, two proteins related to male fertility. Therefore, we demonstrate the alteration of semen proteome in response to COVID-19, thus disrupting the male reproductive function despite the patient’s clinical remission. | |||||||||||||||||||||
51 | Characteristics and impact of Long Covid: Findings from an online survey | 2022-03-08 | https://doi.org/10.1371/journal.pone.0264331 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8903286/ | Nida Ziauddeen | https://pubmed.ncbi.nlm.nih.gov/35259179/ | Most participants described fluctuating (57.7%) or relapsing symptoms (17.6%). Physical activity, stress, and sleep disturbance commonly triggered symptoms. A third (32%) reported they were unable to live alone without any assistance at six weeks from start of illness. 16.9% reported being unable to work solely due to COVID-19 illness. 37.0% reported loss of income due to illness | ||||||||||||||||||||
52 | Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study | 2022-03-16 | https://doi.org/10.1016/S2352-4642(22)00004-9 | Selina Kikkenborg Berg | https://www.sciencedirect.com/science/article/pii/S2352464222000049 | Participants with SARS-CoV-2-positive tests had more long-lasting symptoms and sick leave, whereas participants in the control group had more short-lasting symptoms and worse quality of life. More participants in the case group than in the control group reported 16 or more sick days (1205 [18·2%] vs 2518 [11·6%]; p<0·0001) and 16 or more days of school absence (695 [10·5%] vs 1777 [8·2%]; p<0·0001). | |||||||||||||||||||||
53 | The Incidence of Diabetes Among 2,777,768 Veterans With and Without Recent SARS-CoV-2 Infection | 2022-04-01 | https://doi.org/10.2337/dc21-1686 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9016731/ | Pandora L Wander | https://pubmed.ncbi.nlm.nih.gov/35085391/ | SARS-CoV-2 is associated with higher risk of incident diabetes in men but not in women even after greater surveillance related to hospitalization is accounted for. SARS-CoV-2 was associated with higher risk of incident diabetes, compared with no positive tests, among men (120 days, odds ratio [OR] 2.56 [95% CI 2.32-2.83]; all time, 1.95 [1.80-2.12]) but not women (120 days, 1.21 [0.88-1.68]; all time, 1.04 [0.82-1.31]). | ||||||||||||||||||||
54 | Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study | 2022-04-23 | https://doi.org/10.1016/S2213-2600(22)00127-8 | The PHOSP-COVID Collaborative Group | https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00127-8/fulltext | The sequelae of a hospital admission with COVID-19 were substantial 1 year after discharge across a range of health domains, with the minority in our cohort feeling fully recovered. Patient-perceived health-related quality of life was reduced at 1 year compared with before hospital admission. The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). | |||||||||||||||||||||
55 | COVID-19 infection may trigger poor asthma control in children | 2022-04-26 | https://doi.org/10.1016/j.jaip.2022.04.012 | PMC9040415 | Christine C Chou | https://pmc.ncbi.nlm.nih.gov/articles/PMC9040415/ | COVID+ asthmatic patients showed significant increases in ED visits (incidence rate ratio [IRR] = 1.17) and OCS (oral corticosteroid) fills (IRR = 1.23) in the post-PCR period, and only slight increases in hospitalizations (IRR = 1.13) or SABA use (IRR = 1.02) after infection. However, these slight increases in hospitalization and SABA fill rates in the COVID+ group after infection contrast starkly with the significant decrease in the COVID− group after PCR testing. | ||||||||||||||||||||
56 | Risks and burdens of incident diabetes in long COVID: a cohort study | 2022-05-01 | https://doi.org/10.1016/S2213-8587(22)00044-4 | Yan Xie, MPH | https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00044-4/fulltext | In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during the same period and had not contracted SARS-CoV-2... In the post-acute phase of the disease, compared with the contemporary control group, people with COVID-19 exhibited an increased risk (HR 1·40, 95% CI 1·36–1·44) and excess burden (13·46, 95% CI 12·11–14·84, per 1000 people at 12 months) of incident diabetes. | |||||||||||||||||||||
57 | Increased Risk of Herpes Zoster in Adults ≥50 Years Old Diagnosed With COVID-19 in the United States | 2022-05-01 | https://doi.org/10.1093/ofid/ofac118 | Amit Bhavsar | https://academic.oup.com/ofid/article/9/5/ofac118/6545460?login=true | Individuals diagnosed with COVID-19 had a 15% higher HZ risk than those without COVID-19 (aIRR, 1.15; 95% CI, 1.07–1.24; P < .001). The increased HZ risk was more pronounced (21%) following COVID-19 hospitalization (aIRR, 1.21; 95% CI, 1.03–1.41; P = .02). | |||||||||||||||||||||
58 | A clinical review of long-COVID with a focus on the respiratory system | 2022-05-01 | DOI: 10.1097/MCP.0000000000000863 | Daines, Luke | https://journals.lww.com/co-pulmonarymedicine/abstract/2022/05000/a_clinical_review_of_long_covid_with_a_focus_on.4.aspx | Long-COVID is a debilitating syndrome that often includes persisting respiratory symptoms and to a lesser degree, abnormalities in lung physiology or imaging. Respiratory features of long-COVID may reduce over time, yet resolution is not seen in all cases. | |||||||||||||||||||||
59 | Long COVID-19 syndrome: a 14-months longitudinal study during the two first epidemic peaks in Southeast Brazil | 2022-05-06 | https://doi.org/10.1093/trstmh/trac030 | Daniel A P de Miranda | https://academic.oup.com/trstmh/article/116/11/1007/6581500 | From the whole population, 50.2% presented with long COVID syndrome. Twenty-three different symptoms were reported. Most frequent were fatigue (35.6%), persistent cough (34.0%), dyspnea (26.5%), loss of smell/taste (20.1%) and frequent headaches (17.3%). Mental disorders (20.7%), change in blood pressure (7.4%) and thrombosis (6.2%) were also reported. Most patients presented with 2–3 symptoms at the same time. Long COVID started after mild, moderate and severe infection in 60, 13 and 27% of cases, respectively, and it was not restricted to specific age groups. | |||||||||||||||||||||
60 | Post–COVID Conditions Among Adult COVID-19 Survivors Aged 18–64 and ≥65 Years — United States, March 2020–November 2021 | 2022-05-24 | http://dx.doi.org/10.15585/mmwr.mm7121e1 | Lara Bull-Otterson | https://www.cdc.gov/mmwr/volumes/71/wr/mm7121e1.htm | COVID-19 survivors have twice the risk for developing pulmonary embolism or respiratory conditions; one in five COVID-19 survivors aged 18–64 years and one in four survivors aged ≥65 years experienced at least one incident condition that might be attributable to previous COVID-19. | |||||||||||||||||||||
61 | A systematic review and meta-analysis of long term physical and mental sequelae of COVID-19 pandemic: call for research priority and action | 2022-06-06 | https://doi.org/10.1038/s41380-022-01614-7 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9168643/ | Na Zeng | https://pubmed.ncbi.nlm.nih.gov/35668159/ | At least one sequelae symptom occurred in 50.1% of COVID-19 survivors for up to 12 months after infection. The most common investigation findings included abnormalities on lung CT (and abnormal pulmonary function tests, followed by generalized symptoms, such as fatigue, psychiatric symptoms mainly depression and PTSD, and neurological symptoms, such as cognitive deficits and memory impairment. Survivors with mild infection had high burden of anxiety and memory impairment after recovery. | ||||||||||||||||||||
62 | Risk factors of long term symptoms and outcomes among patients discharged after covid-19: prospective, multicentre observational study | 2022-06-17 | https://doi.org/10.1136/bmjmed-2021-000093 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9951375/ | Matthieu Legrand | https://pubmed.ncbi.nlm.nih.gov/36936553/ | Persistent symptoms after hospital admission were frequent, regardless of acute covid-19 severity. 1109 (50.7%) of 2187 participants had at least one persistent symptom. | ||||||||||||||||||||
63 | Long-COVID in children and adolescents: a systematic review and meta-analyses | 2022-06-23 | https://doi.org/10.1038/s41598-022-13495-5 | Sandra Lopez-Leon | https://www.nature.com/articles/s41598-022-13495-5 | The prevalence of long-COVID was 25.24%, and the most prevalent clinical manifestations were mood symptoms (16.50%), fatigue (9.66%), and sleep disorders (8.42%). Children infected by SARS-CoV-2 had a higher risk of persistent dyspnea, anosmia/ageusia, and/or fever compared to controls. | |||||||||||||||||||||
64 | Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records | 2022-06-28 | https://doi.org/10.1038/s41467-022-30836-0 | Ellen J. Thompson | https://www.nature.com/articles/s41467-022-30836-0 | Proportions of presumed COVID-19 cases in LS (longitudinal study) reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). | |||||||||||||||||||||
65 | Increased Lengths of Stay, ICU, and Ventilator Days in Trauma Patients with Asymptomatic COVID-19 Infection | 2022-07-01 | https://doi.org/10.1177%2F00031348221082290 | PMC9014328 | Garrett N Klutts | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014328/ | Hospital LOS was 2.7 days longer in the COVID-positive group (P < .0005). ICU LOS was 2.9 days longer for patients admitted to the ICU in the COVID positive-group (P = .017). Ventilator days were 4.7 days longer for patients requiring mechanical ventilation in the COVID-positive group (P = .002). Discharge to a post-acute facility required 6.1 more days in the COVID-positive group (P = .005). | ||||||||||||||||||||
66 | Prevalence of and Factors Associated With Post-Coronavirus Disease 2019 (COVID-19) Condition in the 12 Months After the Diagnosis of COVID-19 in Adults Followed in General Practices in Germany | 2022-07-04 | https://doi.org/10.1093/ofid/ofac333 | Karel Kostev | https://pubmed.ncbi.nlm.nih.gov/35891693/ | Post-COVID-19 condition was found in the 12 months after the diagnosis of COVID-19 in approximately 8% of adults from general practices in Germany. The prevalence of PCC was 8.3%. Age >30 years (odds ratios [ORs] ranging from 1.40 for 31-45 years to 2.10 for 46-60 years) and female sex (OR = 1.23) were positively and significantly associated with PCC compared with age 18-30 years and male sex, respectively. | |||||||||||||||||||||
67 | Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID) | 2022-07-06 | https://doi.org/10.1186/s12916-022-02448-4 | Ekaterina Pazukhina | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02448-4 | Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. | |||||||||||||||||||||
68 | SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice | 2022-07-07 | https://doi.org/10.1126/scitranslmed.abo5070 | KENNETH H. DINNON III | https://www.science.org/doi/10.1126/scitranslmed.abo5070 | The authors observed the development of a profibrotic phenotype at later time points after infection; severity of lung damage could be ameliorated by early antifibrotic or antiviral drug treatment. | |||||||||||||||||||||
69 | A Systemic Review and Meta-analysis of the Effect of SARS-CoV-2 Infection on Sperm Parameters | 2022-07-13 | https://doi.org/10.34133/2022/9835731 | Xi Chen | https://spj.science.org/doi/10.34133/2022/9835731 | Our results revealed that SARS-CoV-2 infection was significantly correlated with decreased sperm quality. Of six sperm parameters, total motility and sperm concentration were the most significantly decreased parameters. These results suggest a possible negative influence of SARS-CoV-2 infection on testicular function and male fertility. | |||||||||||||||||||||
70 | Symptoms and risk factors for long COVID in non-hospitalized adults | 2022-07-25 | https://doi.org/10.1038/s41591-022-01909-w | Anuradhaa Subramanian | https://www.researchsquare.com/article/rs-1343889/v1 | A total of 62 symptoms were significantly associated with SARS-CoV-2 infection after 12 weeks. The largest aHRs were for anosmia (aHR 6.49, 95% CI 5.02–8.39), hair loss (3.99, 3.63–4.39), sneezing (2.77, 1.40–5.50), ejaculation difficulty (2.63, 1.61–4.28) and reduced libido (2.36, 1.61–3.47). Among the cohort of patients infected with SARS-CoV-2. | |||||||||||||||||||||
71 | Persistent symptoms, quality of life, and risk factors in long COVID: a cross-sectional study of hospitalized patients in Brazil | 2022-07-28 | https://doi.org/10.1016/j.ijid.2022.07.063 | Jacqueline Ferreira de Oliveira | https://www.ijidonline.com/article/S1201-9712(22)00458-1/fulltext | Of 439 participants, most (84%) reported at least one long COVID symptom, at a median of 138 days after disease onset. Fatigue (63.1%), dyspnea (53.7%), arthralgia (56.1%), and depression/anxiety (55.1%) were the most prevalent symptoms. Fifty percent of patients reported a worsened clinical condition and quality of life. | |||||||||||||||||||||
72 | Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study | 2022-08-06 | https://doi.org/10.1016/S0140-6736(22)01214-4 | Aranka V Ballering, MSc | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01214-4/fulltext | Persistent symptoms in COVID-19-positive participants at 90–150 days after COVID-19 compared with before COVID-19 and compared with matched controls included chest pain, difficulties with breathing, pain when breathing, painful muscles, ageusia or anosmia, tingling extremities, lump in throat, feeling hot and cold alternately, heavy arms or legs, and general tiredness. In 12·7% of patients, these symptoms could be attributed to COVID-19, as 381 (21·4%) of 1782 COVID-19-positive participants versus 361 (8·7%) of 4130 COVID-19-negative controls had at least one of these core symptoms substantially increased to at least moderate severity at 90–150 days after COVID-19 diagnosis or matched timepoint. | |||||||||||||||||||||
73 | Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability | 2022-08-09 | http://dx.doi.org/10.48101/ujms.v127.8794 | Marta A. Kisiel | https://ujms.net/index.php/ujms/article/view/8794/14786 | A total of 366 subjects responded, with 47% reporting persistent symptoms 12 months after their COVID-19 diagnosis. The most commonly reported symptoms at this time were impaired sense of smell and/or taste and fatigue. Respondents with symptoms after 12 months self-reported negatively about their general health and work ability. | |||||||||||||||||||||
74 | Acute Pancreatitis Related to COVID-19 Infection: A Systematic Review and Analysis of Data | 2022-08-25 | https://doi.org/10.7759/cureus.28380 | Ahmed Ali Aziz | https://pmc.ncbi.nlm.nih.gov/articles/PMC9506667/ | Our study provides an important overview of the available data on AP (acute pancreatitis) in COVID-19 patients and concludes that AP is an important complication in COVID-19 infection and should be considered as an important differential in patients with COVID-19 infection who complain of abdominal pain. | |||||||||||||||||||||
75 | Risk of Long COVID in People Infected With Severe Acute Respiratory Syndrome Coronavirus 2 After 2 Doses of a Coronavirus Disease 2019 Vaccine: Community-Based, Matched Cohort Study | 2022-09-12 | https://doi.org/10.1093/ofid/ofac464 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9494414/ | Daniel Ayoubkhani | https://pubmed.ncbi.nlm.nih.gov/36168555/ | Persistent symptoms were reported by 9.5% of 3090 breakthrough severe acute respiratory syndrome coronavirus 2 infections and 14.6% of unvaccinated controls (adjusted odds ratio, 0.59 [95% confidence interval, .50-.69]), emphasizing the need for public health initiatives to increase population-level vaccine uptake. | ||||||||||||||||||||
76 | Pulmonary Dysfunction after Pediatric COVID-19 | 2022-09-20 | https://doi.org/10.1148/radiol.221250 | Rafael Heiss | https://pubs.rsna.org/doi/10.1148/radiol.221250 | Low-field MRI showed persistent pulmonary dysfunction in both children and adolescents recovered from COVID-19 and with long COVID. Both ventilated and perfused lung parenchyma (V/Q match) was reduced from 81±6.1% in healthy controls to 62±19% (P =.006) in the recovered group and 60±20% (P=.003) in the long COVID group. V/Q match was lower in post COVID patients with infection less than 180 days (63±20%, P=.03), 180 to 360 days (63±18%, P=0.03) and 360 days ago (41±12%, P<.001) as compared with the never-infected healthy controls (81±6.1%). | |||||||||||||||||||||
77 | Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021 | 2022-09-23 | 10.1001/jamanetworkopen.2022.33014 | Ellen K. Kendall, BA | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2796649 | At 1, 3, and 6 months after infection, risk of diagnosis of T1D was greater among those infected with SARS-CoV-2 compared with those with non–COVID-19 respiratory infection (1 month: HR, 1.96 [95%CI, 1.26-3.06]; 3 months: HR, 2.10 [95% CI, 1.48-3.00]; 6 months: HR, 1.83 [95% CI, 1.36-2.44]). | |||||||||||||||||||||
78 | Characteristics of long-COVID among older adults: a cross-sectional study | 2022-09-30 | https://doi.org/10.1016/j.ijid.2022.09.035 | Vered Daitch | https://www.ijidonline.com/article/S1201-9712(22)00535-5/fulltext | Older individuals with long-COVID have different persisting symptoms, with more pronounced pulmonary impairment. Older adults were more likely to be symptomatic, with the most common symptoms being fatigue (38%) and dyspnea (30%); they were more likely to complain of cough and arthralgia and have abnormal chest imaging and pulmonary function tests. | |||||||||||||||||||||
79 | Comparison of Persistent Symptoms Following SARS-CoV-2 Infection by Antibody Status in Nonhospitalized Children and Adolescents | 2022-10-01 | doi.org/10.1097/INF.0000000000003653 | Messiah, Sarah | https://journals.lww.com/pidj/abstract/2022/10000/comparison_of_persistent_symptoms_following.12.aspx | Children and adolescents are less likely to experience persistent COVID symptoms than adults and more likely to be symptomatic, experience severe symptoms and have unhealthy weight compared with children/adolescents without persistent COVID symptoms.A total of 82 (4.5% of the total sample [n = 1813], 8.0% pre-Delta, 3.4% Delta and beyond) participants reported persistent COVID symptoms (n = 27 [1.5%] 4–12 weeks, n = 58 [3.3%] >12 weeks). | |||||||||||||||||||||
80 | Longitudinal Analysis of Quadriceps Muscle Strength in Patients with Previous COVID-19 Hospitalization and in Patients with Post-Acute Sequelae following Mild COVID-19 | 2022-10-15 | https://doi.org/10.3390/nu14204319 | Anouk A. F. Stoffels | https://www.mdpi.com/2072-6643/14/20/4319 | Clinically relevant muscle weakness is common after COVID-19 and its long-term improvement is poor. Muscle weakness was found in 59% of post-hospitalized patients and in 65% of those with PASC following mild COVID-19 at ~14 weeks after acute COVID-19. Whereas during ~1.5 years follow-up MVC (maximal voluntary contraction) modestly improved, muscle weakness prevalence remained unchanged. | |||||||||||||||||||||
81 | Effect of COVID‐19 infection on the erectile function | 2022-10-25 | https://doi.org/10.1111%2Fandr.13315 | https://pubmed.ncbi.nlm.nih.gov/36251682 | Remzi Salar | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874733/ | In this study, we determined that SARS‐CoV‐2 infection caused deterioration in existing ED in sexually active male individuals, regardless of the severity of the disease. The changes in the IIEF‐5 scores of the patients from the pre‐disease to the post‐disease period were statistically significant for both the mild and moderate groups (p < 0.05). When these changes were compared between the mild and moderate groups, the difference was not statistically significant (p = 0.156). | ||||||||||||||||||||
82 | Incidence of New or Worsening Overactive Bladder Among Patients with a Prior SARS-CoV-2 Infection: A Cohort Study | 2022-10-27 | https://doi.org/10.1016/j.euros.2022.10.001. | Ly Hoang Roberts | https://www.sciencedirect.com/science/article/pii/S2666168322020389 | COVID-19 infection increases the risk of developing new or worsening OAB (Overactive Bladder) symptoms. | |||||||||||||||||||||
83 | A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients | 2022-10-28 | https://doi.org/10.1101/2022.10.27.514070 | Yered Pita-Juarez, | https://www.biorxiv.org/content/10.1101/2022.10.27.514070v1 | Integrated analysis and comparisons with healthy controls revealed extensive changes in the cellular composition and expression states in COVID-19 liver, reflecting hepatocellular injury, ductular reaction, pathologic vascular expansion, and fibrogenesis. | |||||||||||||||||||||
84 | Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study | 2022-10-31 | https://doi.org/10.1080/02813432.2022.2139480 | Limor Adler | https://www.tandfonline.com/doi/full/10.1080/02813432.2022.2139480 | Long-COVID is frequently seen following a mild symptomatic COVID-19 infection and, to a lesser extent, following an asymptomatic SARS-CoV-2 infection. About 34.6% of participants reported not returning to their baseline health condition after the acute illness. | |||||||||||||||||||||
85 | Post-COVID-19 Symptoms 2 Years After SARS-CoV-2 Infection Among Hospitalized vs Nonhospitalized Patients | 2022-11-01 | https://doi.org/10.1001/jamanetworkopen.2022.42106 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9667330/ | César Fernández-de-Las-Peñas | https://pubmed.ncbi.nlm.nih.gov/36378309/ | This cross-sectional study suggested the presence of at least 1 post-COVID-19 symptom in 59.7% of hospitalized patients and 67.5% of nonhospitalized patients 2 years after infection. Among hospitalized and nonhospitalized patients, fatigue (161 [44.7%] vs 147 [47.7%]), pain (129 [35.8%] vs 92 [29.9%]), and memory loss (72 [20.0%] vs 49 [15.9%]) were the most prevalent post-COVID-19 symptoms 2 years after SARS-CoV-2 infection. | ||||||||||||||||||||
86 | Lingering SARS-CoV-2 in Gastric and Gallbladder Tissues of Patients with Previous COVID-19 Infection Undergoing Bariatric Surgery | 2022-11-01 | https://doi.org/10.1007/s11695-022-06338-9 | Mohamed Hany | https://link.springer.com/article/10.1007/s11695-022-06338-9 | Gastric and gallbladder tissues can retain SARS-CoV-2 particles for a long time after COVID-19 infection. Gastric specimens from 26 (32.5%) patients and 4 (100%) cholecystectomy specimens showed positive cytoplasmic staining for the anti-SARS-CoV-2 nucleocapsid protein in surface mucosal epithelial cells. The positive staining group was significantly younger than the negative staining group. | |||||||||||||||||||||
87 | Altered lung physiology in two cohorts after COVID-19 infection as assessed by computed cardiopulmonography | 2022-11-04 | https://doi.org/10.1152/japplphysiol.00436.2022 | Snapper R. M. Magor-Elliott | https://journals.physiology.org/doi/full/10.1152/japplphysiol.00436.2022 | Irrespectively of COVID-19 severity, participants who had had COVID-19 demonstrated a modest increase in ventilation inhomogeneity, broadly equivalent to that associated with 15 yr of aging. | |||||||||||||||||||||
88 | Post-COVID-19-associated morbidity in children, adolescents, and adults: A matched cohort study including more than 157,000 individuals with COVID-19 in Germany | 2022-11-10 | https://doi.org/10.1371/journal.pmed.1004122 | Martin Roessler | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004122 | For all health outcomes combined, Indicdent Rates (IRs) per 1,000 person-years in the COVID-19 cohort were significantly higher than those in the control cohort in both children/adolescents (IRR: 1.30, 95% CI: 1.25 to 1.35, p < 0.01, IR COVID-19: 436.91, IR Control: 335.98) and adults (IRR: 1.33, 95% CI: 1.31 to 1.34, p < 0.01, IR COVID-19: 615.82, IR Control: 464.15). In the COVID-19 cohort, IRs were significantly higher in all 13 diagnosis/symptom complexes in adults and in 10 diagnosis/symptom complexes in children/adolescents. | |||||||||||||||||||||
89 | Post-COVID-19-associated morbidity in children, adolescents, and adults: A matched cohort study including more than 157,000 individuals with COVID-19 in Germany | 2022-11-10 | https://doi.org/10.1371/journal.pmed.1004122 | Martin Roessler | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004122 | We observed significant new onset morbidity in children, adolescents, and adults across 13 prespecified diagnosis/symptom complexes, following COVID-19 infection. These findings expand the existing available evidence on post-COVID-19 conditions in younger age groups and confirm previous findings in adults. | |||||||||||||||||||||
90 | Asymptomatic SARS-COV-2 infection in children's tonsils | 2022-11-11 | https://doi.org/10.1016/j.bjorl.2022.10.016 | Carolina S.Miura | https://www.sciencedirect.com/science/article/pii/S1808869422001392 | We studied 48 children who underwent adenotonsillectomy between October 2020 and September 2021. None of them had experienced signs or symptoms of acute upper airway infection in the month prior to surgery. SARS-CoV-2 was detected in at least one sample in 12 patients (25%). It remains unclear for how long the lymphoid tissue can sustain the SARS-CoV-2 in a persistent infection | |||||||||||||||||||||
91 | Post–COVID-19 Symptoms 2 Years After SARS-CoV-2 Infection Among Hospitalized vs Nonhospitalized Patients | 2022-11-15 | 10.1001/jamanetworkopen.2022.42106 | Fernández-de-las-Peñas C, | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798446 | The proportion of patients with at least 1 post–COVID-19 symptom 2 years after acute infection was 59.7% for hospitalized patients and 67.5% for those not requiring hospitalization. No significant differences in post–COVID-19 symptoms were seen between hospitalized and nonhospitalized patients. | |||||||||||||||||||||
92 | Elevated circulating monocytes and monocyte activation in pulmonary post-acute sequelae of SARS-CoV-2 infection | 2022-11-20 | https://doi.org/10.1101/2022.11.19.22282543 | Juwon Park | https://www.medrxiv.org/content/10.1101/2022.11.19.22282543v1 | This study present evidence that COVID convalescents exhibit monocyte alteration beyond the acute COVID-19 infection period even in convalescents with no residual symptoms. These data provide further rational for determining the role of monocyte subsets in PPASC (Post-acute sequelae of COVID-19 ) pathogenesis. | |||||||||||||||||||||
93 | Asymptomatic Covid-19 Trauma Patients Have Worse Outcomes and Resource Utilization: A Matched Cohort Study | 2022-11-22 | https://doi.org/10.1097/01.XCS.0000896492.04721.a7 | Sozzi, Marco MD | https://journals.lww.com/journalacs/Fulltext/2022/11002/Asymptomatic_COVID_19_Trauma_Patients_have_Worse.225.aspx | Asymptomatic COVID-19 positive patients had higher rates of myocardial infarction and cardiac arrest (3.2% vs 0.9%, p = 0.023), higher ventilator days (3.33 vs 1.49, p < 0.001), ICU-LOS (length of stay) (4.92 vs 3.41 days, p = 0.034), overall LOS (11.41 vs 7.24 days, p < 0.001) and hospital charges (176.505.80 vs 107.591.93 $, p = 0.002). | |||||||||||||||||||||
94 | Associations between COVID‐19 and hospitalisation with respiratory and non‐respiratory conditions: a record linkage study | 2022-11-28 | 10.5694/mja2.51778 | Stacey L Rowe | https://www.mja.com.au/journal/2022/218/1/associations-between-covid-19-and-hospitalisation-respiratory-and-non | The incidence of hospitalisation within 89 days of onset of COVID‐19 was higher than during the baseline period for several conditions, including myocarditis and pericarditis (IRR, 14.8; 95% CI, 3.2–68.3), thrombocytopenia (IRR, 7.4; 95% CI, 4.4–12.5), pulmonary embolism (IRR, 6.4; 95% CI, 3.6–11.4), acute myocardial infarction (IRR, 3.9; 95% CI, 2.6–5.8), and cerebral infarction (IRR, 2.3; 95% CI, 1.4–3.9). | |||||||||||||||||||||
95 | Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19 | 2022-11-29 | https://doi.org/10.1101/2022.11.28.22282811 | Andre Figueiredo Rendeiro | https://www.medrxiv.org/content/10.1101/2022.11.28.22282811v1 | The fact that in our data we find the level of vascular derangement higher in post-acute than in acute COVID-19 suggests that vascular remodeling is a continuously acting process during post-acute COVID disease. We find evidence of viral presence in the lung up to 359 days after the acute phase of disease, including in patients with negative nasopharyngeal swab tests. At the cellular level, lung disease of PC patients, while distinct, shares pathological features with the chronic pulmonary disease of IPF | |||||||||||||||||||||
96 | Disruption in seasonality, patient characteristics and disparities of respiratory syncytial virus infection among young children in the US during and before the COVID-19 pandemic: 2010-2022 | 2022-11-29 | https://doi.org/10.1101/2022.11.29.22282887 | Lindsey Wang | https://www.medrxiv.org/content/10.1101/2022.11.29.22282887v1 | Among RSV-infected children in 2022, 19.2% had prior documented COVID-19 infection, significantly higher than the 9.7% among uninfected children | |||||||||||||||||||||
97 | New Ultrasound Study Shows Increased Liver Stiffness 10 Months After COVID-19 Infection | 2022-12-01 | Not yet published | Firouzeh Heidari | https://www.diagnosticimaging.com/view/new-ultrasound-study-shows-increased-liver-stiffness-10-months-after-covid-19-infection | COVID-19 infection was associated with an average increase in the median Young’s modulus of 1.71 kPa. The COVID-19 positive group had a higher median liver stiffness (7.68 kPa) in comparison to the pandemic control group (5.99 kPa). | |||||||||||||||||||||
98 | The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis | 2022-12-01 | https://doi.org/10.1016/j.eclinm.2022.101762 | Lauren L. O'Mahoney | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00491-6/fulltext | Our work shows that 45% of COVID-19 survivors, regardless of hospitalisation status, were experiencing a range of unresolved symptoms at ∼ 4 months. Fatigue was frequently reported across hospitalised (28.4%), non-hospitalised (34.8%), and mixed (25.2%) cohorts. Amongst the hospitalised cohort, abnormal CT patterns/x-rays were frequently reported (45.3%), alongside ground glass opacification (41.1%), and impaired diffusion capacity for carbon monoxide (31.7%). | |||||||||||||||||||||
99 | Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study | 2022-12-01 | https://doi.org/10.1164/rccm.202203-0564OC | Iain Stewart | https://www.atsjournals.org/doi/full/10.1164/rccm.202203-0564OC | Residual lung abnormalities were estimated in up to 11% of people discharged after COVID-19–related hospitalization. | |||||||||||||||||||||
100 | Physical and mental health disability associated with long-COVID: Baseline results from a US nationwide cohort | 2022-12-07 | https://doi.org/10.1101/2022.12.07.22283203 | Bryan Lau | https://www.medrxiv.org/content/10.1101/2022.12.07.22283203v1 | Sixty-five percent of long-COVID participants were classified as having at least one disability, compared to 6% of those with resolved-COVID (n=948) and 14% of those with no-COVID (n=633). Of long-COVID participants, about 1% and 5% were classified as critically physically disabled or mentally fatigued, respectively. | |||||||||||||||||||||
101 | Risk of Suicide Attempts and Self-Directed Violence after SARS-CoV-2 Infection: Outcomes from an Emulated Trial of a Nationwide Observational Matched Cohort of US Veterans | 2022-12-26 | https://doi.org/10.1101/2022.12.23.22283902 | Denise M Hynes | https://www.medrxiv.org/content/10.1101/2022.12.23.22283902v1 | Veterans who had a positive SARS-CoV-2 PCR test had a higher risk of suicide attempt and self-directed violence that were greatest within the first 30 days and present for at least one year following.For suicide attempts, short-term HR=2.54 (95% Confidence Interval [CI]: 2.05 to 3.15), long-term HR=1.30 (CI: 1.19 to 1.43) and one-year HR= 1.41 (CI: 1.30, 1.54). For self-directed violence, short-term HR=1.94 (CI: 1.51 to 2.49), long-term HR=1.32 (CI: 1.20 to 1.45), and one-year HR=1.38 (CI:1.26, 1.51). | |||||||||||||||||||||
102 | Weekly Symptom Profiles of Non-hospitalized Individuals Infected with SARS-CoV-2 During the Omicron Outbreak in Hong Kong: A Retrospective Observational Study from a Telemedicine Centre | 2022-12-30 | https://doi.org/10.1002/jmv.28447 | Jingyuan Luo | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28447 | 4718 (40.1%) patients reported symptoms in the first week after positive test... and 2011 (17.1%) in over four weeks. Cough was the most common symptom in all participants. Patients in over 4 weeks had a higher odds of reporting fatigue (1.263, 95% CI 1.139-1.402, p<0.001). Further, having at least two vaccine doses linked to lower odds of having fever (0.675, 95% CI 0.562-0.811, p<0.001), but not associated with the presence of cough and fatigue. | |||||||||||||||||||||
103 | Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study | 2023-01-01 | https://doi.org/10.1016/j.eclinm.2022.101724 | Byorn W.L.Tan | https://www.sciencedirect.com/science/article/pii/S2589537022004540 | COVID-19-associated AKI (Acute Kidney Injury) was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. | |||||||||||||||||||||
104 | Elevated plasma CAF22 are incompletely restored six months after COVID-19 infection in older men | 2023-01-01 | https://doi.org/10.1016/j.exger.2022.112034 | Asima Karim | https://www.sciencedirect.com/science/article/pii/S0531556522003436 | We investigated the age-related muscle decline, termed sarcopenia, before and following the COVID-19 infection in older male patients (n = 87). Altogether, the muscle detriment due to COVID-19 persists six months post-infection, and plasma CAF22 may be helpful to detect muscle and functional decline in these patients. | |||||||||||||||||||||
105 | The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: A systematic review and meta-analysis | 2023-01-01 | https://doi.org/10.1016/j.eclinm.2022.101762 | Lauren L.O'Mahoney | https://www.sciencedirect.com/science/article/pii/S2589537022004916 | On average, at least 45% of COVID-19 survivors, regardless of hospitalisation status, went on to experience at least one unresolved symptom (mean follow-up 126 days). Fatigue was frequently reported across hospitalised (28.4%; 95% CI 24.7%–32.5%), non-hospitalised (34.8%; 95% CI 17.6%–57.2%), and mixed (25.2%; 95% CI 17.7%–34.6%) cohorts. Amongst the hospitalised cohort, abnormal CT patterns/x-rays were frequently reported (45.3%; 95% CI 35.3%–55.7%), alongside ground glass opacification (41.1%; 95% CI 25.7%–58.5%), and impaired diffusion capacity for carbon monoxide (31.7%; 95% CI 25.8%–3.2%). | |||||||||||||||||||||
106 | Causal associations between obstructive sleep apnea and COVID-19: A bidirectional Mendelian randomization study | 2023-01-01 | https://doi.org/10.1016/j.sleep.2022.09.013 | XiangGao | https://www.sciencedirect.com/science/article/pii/S1389945722011431 | Severe respiratory confirmed COVID-19 was correlated with a 4.9% higher risk of OSA (Obstructive Sleep Apnea). | |||||||||||||||||||||
107 | Reduced muscle strength in patients with long-COVID-19 syndrome is mediated by limb muscle mass | 2023-01-01 | https://doi.org/10.1152/japplphysiol.00599.2022 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9762963/ | Robinson Ramírez-Vélez | https://pubmed.ncbi.nlm.nih.gov/36448687/ | Patients with long-COVID-19 syndrome had significantly lower absolute and relative muscle strength measurements than control participants. Results showed that grip strength and leg extension strength were significantly higher in controls than in COVID-19 survivors (mean [SD], 32.82 [10.01] vs. 26.94 [10.33] kg; difference, 5.87 kg; P < 0.001) and (mean [SD], 93.98 [33.73] vs. 71.59 [33.70] kg; difference, 22.38 kg; P < 0.001), respectively). | ||||||||||||||||||||
108 | Long-Term Consequences of Asymptomatic SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis | 2023-01-01 | https://doi.org/10.3390%2Fijerph20021613 | Yirui Ma | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863678/ | The PPs (pooled prevalence) of long-term consequences after asymptomatic SARS-CoV-2 infections were 17.13% for at least one symptom, 15.09% for loss of taste, 14.14% for loss of smell, and 9.33% for fatigue.Our results suggested that there were long-term effects of asymptomatic SARS-CoV-2 infection, such as loss of taste or smell, fatigue, cough and so on. However, the risk of developing long-term symptoms in asymptomatic SARS-CoV-2 infected persons was significantly lower than those in symptomatic SARS-CoV-2 infection cases. | |||||||||||||||||||||
109 | The pattern of cytokines expression and dynamic changes of renal function at 6 months in patients with Omicron COVID-19 | 2023-01-07 | https://doi.org/10.1002/jmv.28477 | Lanbo Teng | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28477 | Omicron patients showed a decline in renal function at follow-up reflecting the trend of CKD (Chronic Kidney Disease). Whereas, compared with renal function in hospital, serum creatinine levels at 6 months increased remarkably; meanwhile, eGFR (estimated glomerular filtration rate) decreased significantly in all patients. | |||||||||||||||||||||
110 | Fatigue after COVID-19 in non-hospitalized patients according to sex | 2023-01-09 | https://doi.org/10.1002/brb3.2849 | Iwona Mazurkiewicz | https://onlinelibrary.wiley.com/doi/10.1002/brb3.2849 | Women, compared to men, more often experienced persistent fatigue, not caused by effort and persisting after rest (for <4 weeks, odds ratio [OR] = 2.31, 95% confidence interval [CI]: 1.13–4.73; for 4–12 weeks, OR = 1.95, 95% CI: 1.06–3.61), non-restorative sleep (for <4 weeks, OR = 2.17, 95% CI: 1.23–3.81; for >12 weeks, OR = 1.95, 95% CI: 1.03–3.71), and sore throat (for <4 weeks, OR = 1.97, 95% CI: 1.03–3.78; for 4–12 weeks, OR = 2.76, 95% CI: 1.05–7.27). | |||||||||||||||||||||
111 | Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study | 2023-01-11 | https://doi.org/10.1136/bmj-2022-072529 | Barak Mizrahi | https://www.bmj.com/content/380/bmj-2022-072529# | Covid-19 infection was significantly associated with increased risks in early (30-180 days) and late periods (180-360 days) for anosmia and dysgeusia (hazard ratio 4.59 in early period; 2.96 in late period), cognitive impairment (1.85; 1.69), dyspnoea (1.79; 1.30), weakness (1.78; 1.30), and palpitations (1.49; 1.16) and with significant but lower excess risk for streptococcal tonsillitis and dizziness. | |||||||||||||||||||||
112 | Long COVID: major findings, mechanisms and recommendations | 2023-01-13 | https://doi.org/10.1038/s41579-022-00846-2 | Hannah E. Davis | https://www.nature.com/articles/s41579-022-00846-2#citeas | Long COVID is a multisystemic illness encompassing ME/CFS, dysautonomia, impacts on multiple organ systems, and vascular and clotting abnormalities. It has already debilitated millions of individuals worldwide, and that number is continuing to grow. A significant proportion of individuals with long COVID may have lifelong disabilities if no action is taken | |||||||||||||||||||||
113 | Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study | 2023-01-17 | https://doi.org/10.1016/S0140-6736(22)02467-9 | Prof Jose Villar, MD | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02467-9/fulltext | Women with a diagnosis had an increased risk for MMMI (maternal morbidity and mortality index) (relative risk [RR] 1·16 [95% CI 1·03–1·31]) and SPMMI (severe perinatal morbidity and mortality index) (RR 1·21 [95% CI 1·00–1·46]). Unvaccinated women with a COVID-19 diagnosis had a greater risk of MMMI (RR 1·36 [95% CI 1·12–1·65]). | |||||||||||||||||||||
114 | Codetections of Other Respiratory Viruses Among Children Hospitalized With COVID-19 | 2023-01-18 | https://doi.org/10.1542/peds.2022-059037 | Nickolas T. Agathis, MD, MPH | https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-059037/190475/Codetections-of-Other-Respiratory-Viruses-Among?autologincheck=redirected | Children with codetections were more likely to be <5 years old (yo), receive increased oxygen support, or be admitted to the ICU (P < .001). Among children <2 yo, respiratory syncytial virus (RSV) codetections were also significantly associated with severe illness (aOR 1.9 [95% CI 1.3–2.9]). | |||||||||||||||||||||
115 | Persistent COVID-19 Symptoms at 6 Months After Onset and the Role of Vaccination Before or After SARS-CoV-2 Infection | 2023-01-18 | doi:10.1001/jamanetworkopen.2022.51360 | Stephanie A. Richard, PhD | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800554 | Participants had higher risk of pulmonary (RR, 2.00; 95% CI, 1.40-2.84), diabetes (RR, 1.46; 95% CI, 1.00-2.13), neurological (RR, 1.29; 95% CI, 1.02-1.64), and mental health–related medical encounters (RR, 1.28; 95% CI, 1.01-1.62) at 6 months after symptom onset than at baseline (before SARS-CoV-2 infection). Participants who were unvaccinated prior to infection (risk ratio [RR], 1.39; 95% CI, 1.04-1.85), reported moderate (RR, 1.80; 95% CI, 1.47-2.22) or severe (RR, 2.25; 95% CI, 1.80-2.81) initial illnesses, had more hospitalized days (RR per each day of hospitalization, 1.02; 95% CI, 1.00-1.03). | |||||||||||||||||||||
116 | Persistent SARS-CoV-2 infection in patients seemingly recovered from COVID-19 | 2023-01-18 | https://doi.org/10.1002/path.6035 | Rossana Bussani | https://onlinelibrary.wiley.com/doi/10.1002/path.6035 | These findings indicate that SARS-CoV-2 infection can persist significantly longer than suggested by standard PCR-negative tests, with specific infection of specific cell types in the lung. (Post-mortem analysis revealed that) Despite apparent virological remission, lung pathology was similar to that observed in acute COVID-19 individuals. Antibodies against both spike and nucleocapsid revealed the frequent (70%) infection of bronchial cartilage chondrocytes and para-bronchial gland epithelial cells. | |||||||||||||||||||||
117 | COVID-19 pneumonia and the subsequent risk of getting active pulmonary tuberculosis: a population-based dynamic cohort study using national insurance claims databases | 2023-01-20 | https://doi.org/10.1016/j.eclinm.2023.101825 | Ponlagrit Kumwichar | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00002-0/fulltext | Having had COVID-19 pneumonia, as opposed to the general population status, was strongly associated with a higher hazard of detectable active PTB (pulmonary tuberculosis). Hazard ratios (95% CIs) of the negative control, asymptomatic, symptomatic COVID-19 without pneumonia, and pneumonia groups were 1.58 (1.08, 2.32), 1.00 (0.25, 4.01), 2.98 (0.74, 11.98), 9.87 (5.64, 17.30) in the first 30 days and 0.97 (0.81, 1.15), 1.41 (0.92, 2.17), 3.85 (2.42, 6.13), and 7.15 (5.54, 9.22) thereafter, respectively. | |||||||||||||||||||||
118 | Long COVID in children and adolescents: COVID-19 follow-up results in third-level pediatric hospital | 2023-01-30 | https://doi.org/10.3389/fped.2023.1016394 | Lourdes María del Carmen Jamaica Balderas | https://www.frontiersin.org/articles/10.3389/fped.2023.1016394/full | 32.6% of the children had persistent symptoms at 2 months, 9.3% at 4 months, and 2.3% at 6 months, including dyspnea, dry cough, fatigue, and runny nose; the main acute complications were severe pneumonia, coagulopathy, nosocomial infections, acute renal injury, cardiac dysfunction, and pulmonary fibrosis. | |||||||||||||||||||||
119 | Natural history of long-COVID in a nationwide, population cohort study | 2023-01-30 | https://doi.org/10.21203/rs.3.rs-2496392/v1 | Jill Pell | https://www.researchsquare.com/article/rs-2496392/v1 | Of those with previous symptomatic infection, 35% reported persistent incomplete/no recovery, 12% improvement and 12% deterioration. At six and 12 months, one or more symptom was reported by 71.5% and 70.7% respectively of those previously infected, compared with 53.5% and 56.5% of those never infected. | |||||||||||||||||||||
120 | Thyroid dysfunction as a long-term post-COVID-19 complication in mild-to-moderate COVID-19 | 2023-01-31 | https://doi.org/10.1080/13102818.2023.2170829 | Vesselina Yanachkova | https://www.tandfonline.com/doi/full/10.1080/13102818.2023.21708299 | Our findings indicate that COVID-19 could have long-term, negative effects on thyroid function. Thyroid dysfunction was registered in 61.1% of the patients (78.3% subclinical hypothyroidism, 13% subclinical hyperthyroidism and 8.7% overt hypothyroidism) two months after COVID-19. Moderate rather than mild manifestation of COVID-19 was significantly associated with a higher risk of thyroid dysfunction (OR 5.33; 95% CI: 1.70–16.69, p = 0.002), presence of thyroglobulin antibodies and need for levothyroxine therapy. | |||||||||||||||||||||
121 | Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India | 2023-02-01 | https://doi.org/10.4103/ijmr.ijmr_1468_21 | Sanjay J Chandnani | https://pubmed.ncbi.nlm.nih.gov/36751745/ | Overall 681 (46%) patient had deranged LFTs (live function tests). Hepatocellular type of injury was most common (93%). Patients with deranged LFTs had more probability of developing severe disease (P<0.001) and mortality (P<0.001). In COVID-19, LFT abnormalities were common, and derangement increased as severity progressed. The presence of deranged LFT worsens the clinical outcome and predicts in-hospital mortality. | |||||||||||||||||||||
122 | SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway | 2023-02-04 | https://doi.org/10.1007/s10522-023-10019-0 | Yuhang Zhang | https://link.springer.com/article/10.1007/s10522-023-10019-0 | The S-protein of SARS-Cov-2 induces cellular senescence of ARPE-19 cells in vitro and the expression of senescence-associated cytokines in zebrafish retina in vivo likely by activating ER stress, ROS, and NF-κb. These results may uncover a potential association between SARS-cov-2 infection and development of AMD (Age-related macular degeneration). | |||||||||||||||||||||
123 | Can COVID-19 have a clinically significant effect on drug metabolism? | 2023-02-05 | https://doi.org/10.1080/14740338.2023.2172158 | Felicia Ceban | https://www.tandfonline.com/doi/full/10.1080/14740338.2023.2172158 | t is additionally observed that approximately 14–53% of those that recover from SARS-CoV-2 infection (especially hospitalized individuals) exhibit compromised hepatic function [Citation16], suggesting potentially long-term alteration of drug metabolism and excretion. | |||||||||||||||||||||
124 | Higher rates of concussion following COVID-19 infection in high school athletes | 2023-02-08 | http://dx.doi.org/10.1136/bjsports-2022-106436 | Garrett S Bullock | https://bjsm.bmj.com/content/early/2023/02/07/bjsports-2022-106436 | (High school) Athletes with recent COVID-19 had a threefold higher rate of concussion (RR=3.1, 95% CI 2.0 to 4.7). This may be related to ongoing COVID-19 sequelae or deconditioning related to reduced training and competition load during the illness and when returning to sport. | |||||||||||||||||||||
125 | Increased mortality in ICU patients ≥70 years old with COVID-19 compared to patients with other pneumonias | 2023-02-08 | https://doi.org/10.1111/jgs.18220 | Lenneke E. M. Haas MD, PhD | https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.18220 | In ICU-patients ≥70 years old, COVID-19 is more severe compared to bacterial or viral pneumonia. ICU-mortality and in-hospital mortality rates of the patients ≥70 years old admitted with COVID-19 were 39.7% and 47.6% respectively, compared to 19.1% and 28.8% for patients with a bacterial pneumonia and 22.7% and 31.8% for the patients with other viral pneumonias. | |||||||||||||||||||||
126 | Liver Function in Patients Up to 20 Months of Long COVID: A Cross-Sectional Study | 2023-02-08 | doi: 10.20944/preprints202302.0145.v1 | Igor Costa de Lima | https://www.preprints.org/manuscript/202302.0145/v1 | Our findings suggest that ALT and AST levels may be elevated in patients with long-term COVID, especially in those hospitalised in the acute phase. In addition, ALT > 29 U/L was associated with other markers of liver injury, such as LDH, GGT, and ferritin. | |||||||||||||||||||||
127 | Epidemiology of post-COVID conditions beyond 1 year: a cross-sectional study | 2023-02-13 | https://doi.org/10.1016/j.puhe.2023.01.008 | S. Morioka | https://www.sciencedirect.com/science/article/pii/S0033350623000173 | We conducted the survey among patients who had recovered from COVID-19... The proportion of participants with at least one symptom at 6, 12, 18, and 24 months after symptom onset or COVID-19 diagnosis was 32.3% (124/384), 30.5% (71/233), 25.8% (24/93), and 33.3% (2/6), respectively. More than one-fourth of patients after recovery from COVID-19, most of whom had had mild disease in the acute phase, had at least one symptom at 6, 12, 18, and 24 months after onset of COVID-19, indicating that not a few patients with COVID-19 suffer from long-term residual symptoms, even in mild cases. | |||||||||||||||||||||
128 | Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study | 2023-02-14 | https://doi.org/10.1177/01410768231154703 | Andrea Dennis | https://journals.sagepub.com/doi/10.1177/01410768231154703 | Organ impairment persisted in 59% of 331 individuals followed up at 1 year post COVID-19, with implications for symptoms, quality of life and longer-term health, signalling the need for prevention and integrated care of long COVID. Extreme breathlessness (38% and 30%), cognitive dysfunction (48% and 38%) and poor health-related quality of life (EQ-5D-5L < 0.7; 57% and 45%) were common at 6 and 12 months, and associated with female gender, younger age and single-organ impairment. Single- and multi-organ impairment were present in 69% and 23% at baseline, persisting in 59% and 27% at follow-up, respectively. | |||||||||||||||||||||
129 | Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection | 2023-02-14 | doi:10.1001/jamanetworkopen.2022.55965 | Alan C. Kwan, MD, MSc | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801415 | Risk of new-onset diabetes (vs benchmark) diagnosis occurring after (90 days after COVID-19 infection) vs before COVID-19 infection was significantly elevated (OR, 1.58; 95% CI, 1.24-2.02; P < .001); however, risks of hypertension and hyperlipidemia vs benchmark diagnoses were not. | |||||||||||||||||||||
130 | Association of Post–COVID-19 Condition Symptoms and Employment Status | 2023-02-15 | doi:10.1001/jamanetworkopen.2022.56152 | Roy H. Perlis | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2801458 | Among 15 308 individuals with prior COVID-19 infection, those with PCC were less likely to be employed full-time and more likely to be unemployed. These differences persisted after adjustment for demographic differences between those with and without PCC. In survey-weighted regression models excluding retired respondents, the presence of PCC was associated with a lower likelihood of working full-time (odds ratio [OR], 0.71 [95% CI, 0.63-0.80]; adjusted OR, 0.84 [95% CI, 0.74-0.96]) and with a higher likelihood of being unemployed (OR, 1.45 [95% CI, 1.22-1.73]; adjusted OR, 1.23 [95% CI, 1.02-1.48]). | |||||||||||||||||||||
131 | COVID-19-Related Neuropathic Pain: A Systematic Review and Meta-Analysis | 2023-02-20 | https://doi.org/10.3390/jcm12041672 | Laura Dawn Williams | https://www.mdpi.com/2077-0383/12/4/1672 | The pooled prevalence of COVID-19-related neuropathic pain was 6.7% (95% CI: 4.7–9.5%) for hospitalised patients during the acute phase and 34.3% (95% CI: 14.3–62%) for long COVID patients. The identified risk factors for COVID-19-related neuropathic pain development included depression, COVID-19 severity and azithromycin use. | |||||||||||||||||||||
132 | Acute bone loss following SARS-CoV-2 infection in mice | 2023-02-22 | https://doi.org/10.1002/jor.25537 | Anne K. Haudenschild | https://onlinelibrary.wiley.com/doi/10.1002/jor.25537 | Utilizing a humanized mouse model of COVID-19, this study provides the first direct evidence that SARS-CoV-2 infection leads to acute bone loss, increased osteoclast number, and thinner growth plates. This bone loss could decrease whole-bone mechanical strength and increase the risk of fragility fractures, particularly in older patients, while thinner growth plates may create growth disturbances in younger patients. | |||||||||||||||||||||
133 | Risk factors for impaired respiratory function post COVID-19: A prospective cohort study of nonhospitalized and hospitalized patients | 2023-02-23 | https://doi.org/10.1111/joim.13614 | Tove Björsell | https://onlinelibrary.wiley.com/doi/10.1111/joim.13614 | Reduced DLCO (Spirometry diffusion capacity) was the major respiratory impairment 3–6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function. | |||||||||||||||||||||
134 | SARS-CoV-2 Effects on Psychophysical Olfactory Scores: Prospective Study With Evaluation Before and 60-Days After Infection | 2023-02-23 | https://doi.org/10.1002/ohn.166 | Luigi Angelo Vaira MD | https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/ohn.166 | ARS-CoV-2 causes a significant reduction in the olfactory function, in particular affecting the olfactory threshold, even in subjects who do not self-report an OD (olfactory dysfunction). The differences between TDI (Odor Threshold, Discimination, and Identification) scores before and after infection were statistically significant (37 [interquartile range (IQR), 34.25-39.25] vs 34.75 [IQR, 32.25-38]; p = .021). | |||||||||||||||||||||
135 | One-Fourth of COVID-19 Patients Have an Impaired Pulmonary Function after 12 Months of Illness Onset | 2023-02-24 | https://dx.doi.org/10.2139/ssrn.4366836 | Hugo D.G. van Willigen | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4366836 | After one year of follow-up, 25% of the participants had an impaired pulmonary function which translates in 11%, 22%, and 48% of the participants with mild, moderate and severe/critical COVID-19. Having more than three comorbidities (p<0·001) and initial severe/critical illness (p<0·001) were associated with slower improvement of pulmonary function over time, adjusted for age and sex. | |||||||||||||||||||||
136 | Innate immune cell activation causes lung fibrosis in a humanized model of long COVID | 2023-02-27 | https://doi.org/10.1073/pnas.2217199120 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10013740/ | Lu Cui | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013740/ | Our data suggest that the SARS-CoV-2 infection elicits an innate immune activation accompanied by a profibrotic program... We show that neutrophils and monocytes and macrophages are the most prevalent innate immune subsets present in these lungs and show a correlation with SARS-CoV-2–associated fibrotic progression, suggesting that these are the immediate effector cells responsible for the chronic inflammation in COVID lung fibrosis. | ||||||||||||||||||||
137 | An observational multi-centric COVID-19 sequelae study among health care workers | 2023-03-01 | https://doi.org/10.1016/j.lansea.2022.100129 | Ajay KumarShukla | https://www.sciencedirect.com/science/article/pii/S2772368222001469 | Between 12 and 52 weeks post discharge after COVID-19 infection... The overall prevalence of COVID sequelae was 30.34%, with fatigue (11.5%) being the most common followed by insomnia (8.5%), difficulty in breathing during activity (6%) and pain in joints (5%). The odds of having any sequelae were significantly higher among participants who had moderate to severe COVID-19 (OR 6.51; 95% CI 3.46–12.23) and lower among males (OR 0.55; 95% CI 0.39–0.76). | |||||||||||||||||||||
138 | COVID-19 compromises iron homeostasis: Transferrin as a target of investigation | 2023-03-01 | https://doi.org/10.1016/j.jtemb.2022.127109 | Ana Carolina MacedoGaiatto | https://www.sciencedirect.com/science/article/pii/S0946672X22001894 | COVID-19 causes changes in several iron cycle pathways, with iron and ferritin levels being markers that reflect the state and evolution of infection, as well as the prognosis of the disease. Serum iron presented lower values in individuals diagnosed with COVID-19, whereas serum ferritin presented much higher values in infected patients. Elderly subjects had lower serum iron levels and higher ferritin levels, and men with COVID-19 had higher ferritin values than women. | |||||||||||||||||||||
139 | Conceptualising the episodic nature of disability among adults living with Long COVID: a qualitative study | 2023-03-01 | doi:10.1136/ bmjgh-2022-011276 | Kelly K O’Brien | https://gh.bmj.com/content/8/3/e011276 | Among this sample of adults living with Long COVID, experiences of disability were described as episodic, characterised by fluctuating health challenges, which may be unpredictable in nature. All participants described health challenges experienced with fluctuating severity and duration over time. | |||||||||||||||||||||
140 | Risk factors associated with limited functional status among out-of-hospital patients 30 days and one year after a diagnosis of COVID-19: a cohort study | 2023-03-03 | https://doi.org/10.1038/s41598-023-30674-0 | Larissa Laskovski | https://www.nature.com/articles/s41598-023-30674-0 | The purpose of this study was to analyze the long-term health consequences at 30 days and one year among people who were not hospitalized after a diagnosis of COVID-19... One year after the diagnosis of COVID-19, 44.3% had at least one self-reported symptom: memory loss (13.6%), gloominess (8.6%), anosmia (7.9%), body pain (7.1%), ageusia (7%), headache (6.4%), and cough (3.6%). 42.9% reported fatigue and 18.6% reported dyspnea. 40.7% reported some limitation, being 24.3% negligible functional limitation, 14.3% slight and 2.1% moderate according to the PCFS. | |||||||||||||||||||||
141 | Untargeted analysis in post-COVID-19 patients reveals dysregulated lipid pathways two years after recovery | 2023-03-03 | https://doi.org/10.3389/fmolb.2023.1100486 | Yamilé López-Hernández | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1100486/full | Results also show that after two years of SARS-CoV-2 infection, some metabolic pathways are not normalized. It was worth noting that some lipid species were downregulated in post-COVID patients, while others were upregulated even within the same lipid family. These lipid dysregulations could explain some of the persistent symptoms reported by patients, especially those related to musculoskeletal disorders. | |||||||||||||||||||||
142 | Long-term gastrointestinal outcomes of COVID-19 | 2023-03-07 | https://doi.org/10.1038/s41467-023-36223-7 | Evan Xu | https://www.nature.com/articles/s41467-023-36223-7 | Beyond the first 30 days of infection, people with COVID-19 exhibited increased risks and 1-year burdens of incident gastrointestinal disorders spanning several disease categories including motility disorders, acid related disorders (dyspepsia, gastroesophageal reflux disease, peptic ulcer disease), functional intestinal disorders, acute pancreatitis, hepatic and biliary disease. The risks were evident in people who were not hospitalized during the acute phase of COVID-19 and increased in a graded fashion across the severity spectrum of the acute phase of COVID-19 (non-hospitalized, hospitalized, and admitted to intensive care). | |||||||||||||||||||||
143 | SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence | 2023-03-09 | https://doi.org/10.1038/s41556-023-01096-x | Ubaldo Gioia | https://www.nature.com/articles/s41556-023-01096-x | SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response.We propose that SARS-CoV-2, by boosting ribonucleoside triphosphate levels to promote its replication at the expense of dNTPs and by hijacking damage-induced long non-coding RNAs’ biology, threatens genome integrity and causes altered DNA damage response activation, induction of inflammation and cellular senescence. | |||||||||||||||||||||
144 | Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study | 2023-03-10 | https://doi.org/10.1016/j.eclinm.2023.101896 | Hamish J.C. McAuley | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00073-1/fulltext | Physical frailty and pre-frailty are common following hospitalisation with COVID-19. Improvement in frailty was seen between 5 and 12 months although two-thirds of the population remained pre-frail or frail. Frail participants had a larger reduction in HRQoL compared with before their COVID-19 illness and were less likely to describe themselves as recovered. | |||||||||||||||||||||
145 | What can autopsy say about COVID-19? A case series of 60 autopsies | 2023-03-12 | https://doi.org/10.1016%2Fj.legalmed.2023.102241 | Simone Grassi | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008096/ | Lungs and kidneys have been shown to play a pivotal role in COVID-19. The gradual worsening of renal function and AKI might be the result of the progressive collapse of cardiopulmonary system... At microscopic examination, 40 (67%) of the patients presented pulmonary intravascular coagulation with an inflammatory pattern. Myocardiosclerosis was the main heart finding (n = 44; 73%). Liver involvement with congestion and hypotrophy was found in 33 (55%) of cadavers. During hospitalization 31% of patients (n = 19) developed acute kidney injury (AKI). | |||||||||||||||||||||
146 | Urine proteomic characterization of active and recovered COVID-19 patients | 2023-03-13 | https://doi.org/10.1101/2023.03.12.532269 | Jianping Sun | https://www.biorxiv.org/content/10.1101/2023.03.12.532269v1 | The patients who recovered from COVID-19 still exhibited an innate immune response, coagulation system changes and central nervous system changes. | |||||||||||||||||||||
147 | How long is the long COVID? a retrospective analysis of football players in two major European Championships | 2023-03-14 | https://doi.org/10.1101/2023.03.11.23287138 | Sandra Miccinilli | https://www.medrxiv.org/content/10.1101/2023.03.11.23287138v1 | This retrospective cohort study revealed a significant association between SARS-CoV-2 infection and increased risk of muscle injury.. Multiple linear regression analysis confirmed that belonging to C+ in the season 2020/2021 was the variable that most strongly influenced the probability of having a muscle injury in both championships. | |||||||||||||||||||||
148 | Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction | 2023-03-15 | https://doi.org/10.1038/s41443-023-00687-4 | Kevin J. Hebert | https://www.nature.com/articles/s41443-023-00687-4 | rior to the widespread implementation of the COVID-19 vaccine, the incidence of newly diagnosed erectile dysfunction is higher in men with prior COVID-19 infection compared to age-matched controls. Prior COVID-19 infection was associated with a 27% increased likelihood of developing new-onset erectile dysfunction when compared to those without prior infection. | |||||||||||||||||||||
149 | SARS-CoV-2 restructures host chromatin architecture | 2023-03-23 | https://doi.org/10.1038/s41564-023-01344-8 | Ruoyu Wang | https://www.nature.com/articles/s41564-023-01344-8 | Here we characterized the 3D genome and epigenome of human cells after SARS-CoV-2 infection, finding widespread host chromatin restructuring that features widespread compartment A weakening, A–B mixing, reduced intra-TAD contacts and decreased H3K27ac euchromatin modification levels. Such changes were not found following common-cold-virus HCoV-OC43 infection.These findings show that SARS-CoV-2 acutely rewires host chromatin. | |||||||||||||||||||||
150 | A silent march-Post covid fibrosis in asymptomatics – A cause for concern? | 2023-04-01 | https://doi.org/10.1016/j.ijtb.2022.05.004 | Thomas Antony | https://www.sciencedirect.com/science/article/pii/S0019570722000725 | Post-COVID fibrosis can develop even in asymptomatic COVID-19 cases and in those with mild disease and the pattern of fibrosis closely mimics usual interstitial pneumonia (UIP) radiologically. In the post-pandemic era, post-COVID fibrosis should be considered as one of the differential diagnosis in all patients with recent onset of pulmonary fibrosis. | |||||||||||||||||||||
151 | Risk of Death in Patients Hospitalized for COVID-19 vs Seasonal Influenza in Fall-Winter 2022-2023 | 2023-04-06 | doi:10.1001/jama.2023.5348 | Yan Xie, PhD | https://jamanetwork.com/journals/jama/fullarticle/2803749 | The death rate at 30 days was 5.97% for COVID-19 and 3.75% for influenza, with an excess death rate of 2.23% (95% CI, 1.32%-3.13%) (Figure). Compared with hospitalization for influenza, hospitalization for COVID-19 was associated with a higher risk of death (hazard ratio, 1.61 [95% CI, 1.29-2.02]). The risk of death decreased with the number of COVID-19 vaccinations (P = .009 for interaction between unvaccinated and vaccinated; P < .001 for interaction between unvaccinated and boosted). | |||||||||||||||||||||
152 | Risk factors for post-COVID-19 condition (Long Covid) in children: a prospective cohort study | 2023-04-13 | https://doi.org/10.1016/j.eclinm.2023.101961 | Rosa Morello | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00138-4/fulltext | 1243 children were included, median age: 7.5 (4–10.3) years old; 575 (46.3%) were females. Of these, 23% (294/1243) were diagnosed with PCC at three months post-onset. Among the study population, 143 patients remained symptomatic at six months, 38 at 12 months, and 15 at 18 months follow up evaluation.Most children recovered over time, but one-in-twenty of those with PCC at three months reported persistent symptoms 18 months post-Sars-CoV-2 infection. We did not find a strong protective effect of vaccination on PCC development. | |||||||||||||||||||||
153 | Associations between SARS-CoV-2 infection and incidence of new chronic condition diagnoses: a systematic review | 2023-04-18 | https://doi.org/10.1080/22221751.2023.2204166 | Lindsay A. Gaudet | https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2204166 | we had the most certainty in associations between SARS-CoV-2 infection and new diagnoses of chronic conditions, especially cardiac conditions, in outpatient/mixed care samples aged ≥65 years. People in this age category are already at increased risk of many chronic conditions and are more susceptible to poor outcomes after SARS-CoV-2 infection. We also had moderate to high certainty in associations between SARS-CoV-2 infection and at least a small increase of new diagnoses of several chronic conditions in individuals 18-64 years old and a few chronic conditions in individuals <18 years (i.e., trauma and stress disorders, chronic fatigue syndrome, and stroke). | |||||||||||||||||||||
154 | Long-term risk of herpes zoster following COVID-19: A retrospective cohort study of 2 442 686 patients | 2023-04-18 | https://doi.org/10.1002/jmv.28745 | Yi-Chen Chen | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28745 | During the 1-year follow-up period, patients with COVID-19 had a higher risk of HZ compared with those without COVID-19 (HR: 1.59; 95% CI: 1.49–1.69). In addition, compared with the control group patients, those with COVID-19 had a higher risk of HZ ophthalmicus (HR: 1.31; 95% CI: 1.01–1.71), disseminated zoster (HR: 2.80; 95% CI: 1.37–5.74), zoster with other complications (HR: 1.46; 95% CI: 1.18–1.79), and zoster without complications (HR: 1.66; 95% CI: 1.55–1.77). The higher risk of HZ in the COVID-19 cohort compared with that in the non-COVID-19 cohort remained consistent across subgroup analyses regardless of vaccine status, age, or sex. | |||||||||||||||||||||
155 | Association of COVID-19 Infection With Incident Diabetes | 2023-04-18 | doi:10.1001/jamanetworkopen.2023.8866 | Zaeema Naveed | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803938 | The hazard of incident diabetes was significantly higher among individuals who tested positive for SARS-CoV-2 infection than those who tested negative. The fraction of incident diabetes cases attributable to SARS-CoV-2 infection was 3% to 5%. | |||||||||||||||||||||
156 | Prevalence and characteristics of long COVID in elderly patients | 2023-04-17 | https://doi.org/10.1371/journal.pmed.1004194 | Kin Wah Fung | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004194 | Long COVID occurred in 16.6% of outpatients and 29.2% of inpatients. The corresponding rates for long Flu were 17% and 24.6%. Despite the similar overall incidence rates, long COVID patients suffered with notably different symptoms compared to long Flu patients and were also more likely to access inpatient and outpatient healthcare services. | |||||||||||||||||||||
157 | COVID-19 illness severity and 2-year prevalence of physical symptoms: an observational study in Iceland, Sweden, Norway and Denmark | 2023-04-20 | https://doi.org/10.1101/2023.04.18.23288720 | Qing Shen | https://www.medrxiv.org/content/10.1101/2023.04.18.23288720v1 | Individuals who were diagnosed with COVID-19, compared to those not diagnosed, had an overall 37% higher prevalence of severe physical symptom burden. The prevalence was associated with acute COVID-19 severity: individuals bedridden for seven days or longer presented with the highest prevalence (PR 2.25[1.85-2.74]), while individuals never bedridden presented with similar prevalence as individuals not diagnosed with COVID-19 (PR 0.92 [0.68-1.24]). | |||||||||||||||||||||
158 | COVID-19 induced liver injury from a new perspective: Mitochondria | 2023-05-01 | https://doi.org/10.1016/j.mito.2023.04.001 | Hassan Akbari | https://www.sciencedirect.com/science/article/pii/S1567724923000338 | Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the causative agent of COVID-19, can damage hepatocytes through direct cytopathic effects or indirectly after the profound inflammatory response. SARS-CoV-2 hijacks the hepatocytes’ mitochondria to support its replication. In addition, this process can lead to an improper immune response against SARS-CoV-2. | |||||||||||||||||||||
159 | Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study | 2023-05-01 | https://www.medrxiv.org/content/10.1101/2021.07.23.21260716v7 | Sumit Kumar Rawat | https://xmed.jmir.org/2024/1/e48629 | Among the 5539 children tested for SARS-CoV-2, a total of 475 (8.6%) tested positive and 47 (0.8%) presented with hepatitis. Among the 47 children with hepatitis... 10 (21%) had features of MIS-C–associated hepatitis: multiple system involvement; protracted illness (mean length of stay 8 d); and requiring admission to critical care, with a mortality rate of 30%. Our data suggest that CAH-C (COVID-19–associated hepatitis in children) might be one of the new clinical complications associated with the emergence of newer variants of concern of SARS-CoV-2. | |||||||||||||||||||||
160 | Long-term post-acute sequelae of COVID-19 infection: a retrospective, multi-database cohort study in Hong Kong and the UK | 2023-05-11 | https://doi.org/10.1016/j.eclinm.2023.102000 | Ivan Chun Hang Lam | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2823%2900177-3/fulltext | Patients with COVID-19 incurred greater risk of heart failure (HR 1.82; 95% CI 1.65, 2.01), atrial fibrillation (1.31; 1.16, 1.48), coronary artery disease (1.32; 1.07, 1.63), deep vein thrombosis (1.74; 1.27, 2.37), chronic pulmonary disease (1.61; 1.40, 1.85), acute respiratory distress syndrome (1.89; 1.04, 3.43), interstitial lung disease (3.91; 2.36, 6.50), seizure (2.32; 1.12, 4.79), anxiety disorder (1.65; 1.29, 2.09), post-traumatic stress disorder (1.52; 1.23, 1.87), end-stage renal disease (1.76; 1.31, 2.38), acute kidney injury (2.14; 1.69, 2.71), pancreatitis (1.42; 1.10, 1.83), cardiovascular (2.86; 1.25, 6.51) and all-cause mortality (4.16; 2.11, 8.21) mortality during their post-acute phase of infection. | |||||||||||||||||||||
161 | Trajectories of the evolution of post-COVID-19 condition, up to two years after symptoms onset | 2023-05-12 | https://doi.org/10.1016/j.ijid.2023.05.007 | Clemence Servier | https://www.ijidonline.com/article/S1201-9712(23)00558-1/fulltext | The natural history of post-COVID-19 condition reveals that most patients will have persistent symptoms with only little improvement over time, whereas approximately 5% of patients will have rapidly decreasing symptoms within 2 years after symptom onset. Three trajectories of the evolution of post-COVID-19 condition were identified: “high persistent symptoms” (4%), “rapidly decreasing symptoms” (5%), and “slowly decreasing symptoms” (91%). Among participants with slowly decreasing symptoms, the proportion of participants reporting “less than weekly” relapses increased from 11% to 30% between symptom onset and ≥18 months after onset. | |||||||||||||||||||||
162 | Differences in clinical characteristics and outcomes between COVID-19 and influenza in critically ill adult patients: A national database study | 2023-05-16 | https://doi.org/10.1016/j.jinf.2023.05.011 | Diane Naouri | https://www.journalofinfection.com/article/S0163-4453(23)00289-X/fulltext | Hospital mortality was 25% and 21% (p < 0·001) in patients with COVID-19 and influenza, respectively. In the subgroup of patients receiving invasive mechanical ventilation, ICU length of stay was significantly longer in patients with COVID-19 (18 [10–32] vs. 15 [8–26] days, p < 0·001). Adjusting for age, gender, comorbidities, and modified SAPS II score, in-hospital death was higher in COVID-19 patients (adjusted sub-distribution hazard ratio [aSHR]=1.69; 95%CI=1.63–1.75) compared with influenza patients. | |||||||||||||||||||||
163 | Cardiopulmonary testing in long COVID-19 versus non–COVID-19 patients with undifferentiated Dyspnea on exertion | 2023-05-19 | https://doi.org/10.1016/j.pcad.2023.05.005 | Alejandra Meza Contreras | https://www.sciencedirect.com/science/article/pii/S0033062023000531 | We identified severe exercise limitation among long COVID patients. The most prominent difference on CPETs was lower percent predicted peak V̇O2 (73 ± 18 vs 85 ± 23%, p < .0001). Autonomic abnormalities (resting tachycardia, CNS changes, low systolic blood pressure) were seen during CPET more commonly in long COVID patients (34 vs 23%, P < .04), while mild pulmonary abnormalities (mild desaturation, limited breathing reserve, elevated V̇E/V̇CO2) during CPET were similar (19% in both groups). | |||||||||||||||||||||
164 | Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19 | 2023-05-22 | doi:10.1001/jama.2023.8674 | Andreas Weiss | https://jamanetwork.com/journals/jama/fullarticle/2805461 | The incidence rate of type 1 diabetes during the pandemic was 28.5 (95% CI, 26.3-30.9; 620 cases) per 100 000 person-years in the absence of a preceding or concurrent COVID-19 diagnosis. In comparison, the incidence rate of type 1 diabetes was 55.2 (95% CI, 37.1-81.5; 27 cases) per 100 000 person-years in the same quarter as the COVID-19 diagnosis (P < .001 vs COVID-19 negative)... The age- and sex-adjusted hazard ratio for type 1 diabetes development in 2020-2021 was 1.57 (95% CI, 1.32-1.88; P < .001) with any COVID-19 diagnosis and 1.69 (95% CI, 1.31-2.18; P < .001) when only virus-confirmed cases were considered. | |||||||||||||||||||||
165 | Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues | 2023-05-22 | https://doi.org/10.3389/fmicb.2023.1192832 | Santiago Maffia-Bizzozero | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1192832/full | These findings highlight that SARS-CoV-2 can spread to multiple tissue locations such as the lungs, heart, liver, kidneys, and intestines, both after primary infection and after reinfections with the Omicron variant. Different amounts of replication-competent virus were detected in the culture media from the studied tissues. The highest viral load were measured in the lung (≈1.4 × 106 copies/mL) and heart (≈1.9 × 106 copies/mL) samples. | |||||||||||||||||||||
166 | Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues | 2023-05-22 | https://doi.org/10.3389%2Ffmicb.2023.1192832 | PMC10240073 | Santiago Maffia-Bizzozero | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240073/ | All tissues analyzed showed the presence of SARS-CoV-2 genomic RNA but at dissimilar levels ranging from 1.01 × 102 copies/mL to 1.14 × 108 copies/mL, even among those cases who had been COVID-19 vaccinated. Importantly, different amounts of replication-competent virus were detected in the culture media from the studied tissues. The highest viral load were measured in the lung (≈1.4 × 106 copies/mL) and heart (≈1.9 × 106 copies/mL) samples. | ||||||||||||||||||||
167 | Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study | 2023-05-31 | https://doi.org/10.1136/bmj-2022-074425 | Tala Ballouz | https://www.bmj.com/content/381/bmj-2022-074425 | 22.9% (95% confidence interval 20.4% to 25.6%) of individuals infected with SARS-CoV-2 did not fully recover by six months. The proportion of individuals who had an infection who reported not having recovered decreased to 18.5% (16.2% to 21.1%) at 12 months and 17.2% (14.0% to 20.8%) at 24 months after infection. | |||||||||||||||||||||
168 | Post-COVID-19 Syndrome in Non-Hospitalized Individuals: Healthcare Situation 2 Years after SARS-CoV-2 Infection | 2023-06-05 | https://doi.org/10.3390/v15061326 | Inge Kirchberger | https://www.mdpi.com/1999-4915/15/6/1326 | In general, the frequency of COVID-19 related symptoms was higher at 26 months after the onset of the disease than at 9 months after. The present study showed that a number of healthcare providers were involved in the healthcare of individuals with PCS in the second year after the onset of the disease more often than in persons without PCS. | |||||||||||||||||||||
169 | Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence | 2023-06-07 | https://doi.org/10.1007/s11892-023-01515-1 | Rachel Wong | https://pmc.ncbi.nlm.nih.gov/articles/PMC10244847/ | SARS-CoV-2 infection is associated with an increased risk of incident diabetes. Incident diabetes risk increased by approximately 60% compared to patients without SARS-CoV-2 infection. Risk also increased compared to non-COVID-19 respiratory infections, suggesting SARS-CoV-2-mediated mechanisms rather than general morbidity after respiratory illness. | |||||||||||||||||||||
170 | Mild SARS-CoV-2 infection results in long-lasting microbiota instability | 2023-06-09 | https://doi.org/10.1128/mbio.00889-23 | Vaibhav Upadhyay | https://journals.asm.org/doi/10.1128/mbio.00889-23 | Even mild cases of SARS-CoV-2 can disrupt gut microbial ecology. We report a long-lasting instability in the gut microbiota. Surprisingly, our mouse experiments revealed an impact of the Omicron variant, despite producing the least severe symptoms in genetically susceptible mice, suggesting that despite the continued evolution of SARS-CoV-2, it has retained its ability to perturb the intestinal mucosa. | |||||||||||||||||||||
171 | Post-acute sequelae of COVID-19 in older persons: multi-organ complications and mortality | 2023-06-13 | https://doi.org/10.1093/jtm/taad082 | Eric Yuk Fai Wan, PhD | https://academic.oup.com/jtm/advance-article-abstract/doi/10.1093/jtm/taad082/7197126?redirectedFrom=fulltext&login=false | COVID-19 is associated with long-term risks of multi-organ complications in older adults (aged ≥60). Older adults with COVID-19 were associated with a significantly higher risk of cardiovascular outcomes [major cardiovascular disease (stroke, heart failure and coronary heart disease):hazard ratio in UK Biobank/UKB: 1.4, Hong Kong/HK:1.2 and and all-cause mortality HR (UKB): 4.8 , HK:2.7. | |||||||||||||||||||||
172 | Prevalence and risk factors of long COVID 6–12 months after infection with the Omicron variant among nonhospitalized patients in Hong Kong | 2023-06-19 | https://doi.org/10.1002/jmv.28862 | Jingyuan Luo | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28862 | Omicron infection can lead to long COVID in a significant proportion of nonhospitalized patients 6–12 months after infection. Three thousand four hundred and thirty (55.0%) subjects reported at least one long COVID symptom. The most reported symptom was fatigue (1241, 36.2%). Patients who had received three or more doses of vaccine were not associated with a lower risk of long COVID (adjusted odds ratio 1.105, 95% confidence interval 0.985–1.239, p = 0.088). | |||||||||||||||||||||
173 | Long-term effect of COVID-19 infection on kidney function among COVID-19 patients followed in post-COVID recovery clinic in British Columbia, Canada | 2023-06-22 | https://doi.org/10.1093/ndt/gfad121 | Mohammad Atiquzzaman | https://academic.oup.com/ndt/advance-article-abstract/doi/10.1093/ndt/gfad121/7205512?login=false | People with long-term COVID experienced substantial decline in eGFR (estimated glomerular filtration rate) within one year from the infection date. The prevalence of proteinuria appeared to be high. Close monitoring of kidney function is prudent among patients with persistent COVID-19 symptoms. | |||||||||||||||||||||
174 | COVID-related dysphonia and persistent long-COVID voice sequelae: A systematic review and meta-analysis | 2023-06-22 | https://doi.org/10.1016/j.amjoto.2023.103950 | Chung-Wei Lin | https://www.sciencedirect.com/science/article/pii/S0196070923001643?via%3Dihub | A quarter of the COVID-19 patients, especially female, suffered from voice impairment during infection, and approximately 70 % of these dysphonic patients kept experiencing long-lasting voice sequelae. 20.1 % (95 % CI: 8.6 to 40.2 %) of the total patients experienced long-COVID dysphonia. | |||||||||||||||||||||
175 | Viral persistence in children infected with SARS-CoV-2: current evidence and future research strategies | 2023-06-26 | https://doi.org/10.1016/S2666-5247(23)00115-5 | Danilo Buonsenso | https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00115-5/fulltext | Evidence exists for the possible spread of SARS-CoV-2 spread into different organs and persistence for weeks to months after initial infection, even in children independently from severity of the acute disease. Viral RNA has been documented in children who have died from critical acute disease, but also in paediatric patients diagnosed with multisystem inflammatory syndrome weeks to months after previous asymptomatic or mild infection with SARS-CoV-2. | |||||||||||||||||||||
176 | Incidence of Epstein-Barr virus reactivation is elevated in COVID-19 patients | 2023-06-26 | https://doi.org/10.1016%2Fj.virusres.2023.199157 | PMC10292739 | Keishanne Danielle E. Bernal | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292739/ | 27.1% (13/48) of EBV reactivations, based on qPCR detection of EBV genomes, are from the COVID positive group while only 12.5% (6/48) of reactivations belonged to the negative group. In conclusion, COVID-19 patients experienced increased reactivation of EBV in comparison to COVID negative patients. | ||||||||||||||||||||
177 | Latent class analysis of post-acute sequelae of SARS-CoV-2 infection | 2023-06-26 | https://doi.org/10.1080/10543406.2024.2424844 | Xiaowu Sun | https://www.tandfonline.com/doi/full/10.1080/10543406.2024.2424844 | At week 4, participants reported an average of 3.1 PASC-related symptoms, with symptoms declining gradually to 2.6 by Month 6. The most common symptoms at week 4 were tiredness (41%), cough (26%), difficulty thinking (26%), and difficulty sleeping (25%). Except for cough, which declined rapidly, the three most common symptoms remained somewhat stable over month 3 and month 6. | |||||||||||||||||||||
178 | Post-COVID-19 Syndrome 2 Years After the First Wave: The Role of Humoral Response, Vaccination and Reinfection | 2023-07-01 | https://doi.org/10.1093/ofid/ofad364 | Maddalena Peghin | https://academic.oup.com/ofid/article/10/7/ofad364/7223659 | Two years after COVID-19, the burden of persistent symptoms remains high among in- and outpatients’ population infected during the first wave. Post-COVID-19 syndrome was observed in 36.1% of patients (n = 83) at 2 years. The most common persistent symptoms were fatigue (14.4%), rheumatological (14.4%), and psychiatric symptoms (9.6%). Vaccination and reinfection had no impact on post-COVID-19 syndrome dynamics. | |||||||||||||||||||||
179 | Increased Hospitalizations Involving Fungal Infections during COVID-19 Pandemic, United States, January 2020–December 2021 | 2023-07-01 | https://doi.org/10.3201%2Feid2907.221771 | Jeremy A.W. Gold | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310397/ | During 2020–2021, patients hospitalized with COVID-19–associated fungal infections had higher (48.5%) in-hospital mortality rates than those with non–COVID-19–associated fungal infections (12.3%)... COVID-19 infection is a substantial risk factor for certain fungal infections, particularly those caused by invasive molds, likely because of COVID-19–related immune system dysregulation and immunosuppressive therapies, such as corticosteroids or other immunomodulatory medications. | |||||||||||||||||||||
180 | Long COVID prevalence and impact on quality of life 2 years after acute COVID-19 | 2023-07-11 | https://doi.org/10.1038/s41598-023-36995-4 | Yoonjung Kim | https://www.nature.com/articles/s41598-023-36995-4 | Among the 132 participants, 94 (71.2%) experienced symptoms of long COVID. The most frequently reported symptoms were fatigue (34.8%), amnesia (30.3%), concentration difficulties (24.2%), insomnia (20.5%), and depression (19.7%). Although the neuropsychiatric quality of life improved over time, it continued to affect 32.7% of participants. Symptoms of long COVID, particularly neuropsychiatric symptoms, tend to persist over time, and COVID-19 vaccination or the number of vaccinations received may not significantly affect the incidence of long COVID. | |||||||||||||||||||||
181 | A Systematic Review of Persistent Clinical Features After SARS-CoV-2 in the Pediatric Population | 2023-07-21 | https://doi.org/10.1542/peds.2022-060351 | Li Jiang | https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-060351/192816/A-Systematic-Review-of-Persistent-Clinical?autologincheck=redirected | 16.2% (95% confidence interval 8.5% to 28.6%) of the pediatric participants experienced 1 or more persistent symptom(s) at least 3 months post COVID-19. | |||||||||||||||||||||
182 | Determinants of post discharge mortality among hospitalized COVID-19 patients | 2023-08-01 | https://doi.org/10.4103/ijmr.ijmr_973_23 | Gunjan Kumar | https://pubmed.ncbi.nlm.nih.gov/37675689/ | The one year post discharge mortality was 6.5 per cent (n=942). Age [≤18 yr: adjusted odds ratio (aOR) (95% confidence interval [CI]): 1.7 (1.04, 2.9); 40-59 yr: aOR (95% CI): 2.6 (1.9, 3.6); ≥60 yr: aOR (95% CI): 4.2 (3.1, 5.7)], male gender [aOR (95% CI): 1.3 (1.1, 1.5)], moderate-to-severe COVID-19 [aOR (95% CI): 1.4 (1.2, 1.8)] and comorbidities [aOR (95%CI): 1.8 (1.4, 2.2)] were associated with higher odds of post-discharge one-year mortality. | |||||||||||||||||||||
183 | Post-acute health care costs following SARS-CoV-2 infection: A retrospective cohort study of among 531,182 matched adults | 2023-08-04 | https://doi.org/10.1101/2023.08.02.23293563 | Candace D. McNaughton | https://www.medrxiv.org/content/10.1101/2023.08.02.23293563v1 | For 531,182 individuals, mean person-specific total health care costs were $513.83 (95% CI $387.37-$638.40) higher for test-positive females and $459.10 (95% CI $304.60-$615.32) higher for test-positive males, or >10% increase in mean per-capita costs, driven by hospitalization, long-term care, and complex continuing care costs. | |||||||||||||||||||||
184 | Long COVID in a highly vaccinated population infected during a SARS-CoV-2 Omicron wave – Australia, 2022 | 2023-08-09 | https://doi.org/10.1101/2023.08.06.23293706 | Mulu Woldegiorgis | https://www.medrxiv.org/content/10.1101/2023.08.06.23293706v1 | In a highly vaccinated population (94% with >=3 vaccine doses), almost 20% of persons infected with the SARS-CoV-2 Omicron variant reported symptoms consistent with Long COVID 90 days post diagnosis. Long COVID was associated with sustained negative impacts on work/study and a substantial utilisation of GP services 2-3 months after the acute illness; however, ED presentations and hospitalisations for Long COVID were rare. | |||||||||||||||||||||
185 | Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts | 2023-08-09 | https://doi.org/10.1126/scitranslmed.abq1533 | JOSEPH W. GUARNIERI | https://www.science.org/doi/10.1126/scitranslmed.abq1533 | Even when the virus was cleared and lung mitochondrial function had recovered, mitochondrial function in the heart, kidney, liver, and lymph nodes remained impaired, potentially leading to severe COVID-19 pathology. | |||||||||||||||||||||
186 | Long COVID and Significant Activity Limitation Among Adults, by Age — United States, June 1–13, 2022, to June 7–19, 2023 | 2023-08-11 | http://dx.doi.org/10.15585/mmwr.mm7232a3 | Nicole D. Ford | https://www.cdc.gov/mmwr/volumes/72/wr/mm7232a3.htm?s_cid=mm7232a3_w | After an initial decline, prevalence remained unchanged beginning January 4–16, 2023. Approximately one quarter of adults with long COVID report significant activity limitations. During June 7–19, 2023, 26.4% (95% CI = 24.0–28.9) of adults with long COVID reported significant activity limitation, the prevalence of which did not change over time. | |||||||||||||||||||||
187 | Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months | 2023-08-12 | https://doi.org/10.1016/j.cmi.2023.08.007 | Dominik Dietler | https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00388-9/fulltext | PFvac (Preventable Fraction of those vaccinated) was above 90% during the first month after vaccination, regardless of the number of vaccine doses. After six months, PFvac of two doses waned to 34% (95% confidence interval: -30–66%). PFinf (Preventable Fraction of those infected) for people surviving a SARS-CoV-2 infection waned from 88% (-16–99%) three months after infection to 62% (34–79%) after 9 months. No differences in waning patterns in PFvac were seen between virus variants, gender, and age. | |||||||||||||||||||||
188 | Systemic Anticancer Therapy and Thromboembolic Outcomes in Hospitalized Patients With Cancer and COVID-19 | 2023-08-17 | doi:10.1001/jamaoncol.2023.2934 | Shuchi Gulati | https://jamanetwork.com/journals/jamaoncology/fullarticle/2808502 | Patients with active cancer and COVID-19 had a higher risk of developing venous thromboembolism when exposed to systemic anticancer therapies within 3 months prior to COVID-19 diagnosis compared with patients not receiving systemic therapy. | |||||||||||||||||||||
189 | Pediatric infection with the Omicron variant increases the risks of febrile seizures among COVID-19 infected children | 2023-08-17 | https://doi.org/10.3389/fped.2023.1226403 | Zakaria Ahmed Mohamed | https://www.frontiersin.org/articles/10.3389/fped.2023.1226403/full | A significant increase in FS (febrile seizures) was observed in children with Omicron SARS-CoV-2 infection. | |||||||||||||||||||||
190 | Postacute sequelae of COVID-19 at 2 years | 2023-08-21 | https://doi.org/10.1038/s41591-023-02521-2 | Benjamin Bowe | https://www.nature.com/articles/s41591-023-02521-2 | The increased risk of death was not significant beyond 6 months after infection among nonhospitalized but remained significantly elevated through the 2 years in hospitalized individuals. Within the 80 prespecified sequelae, 69% and 35% of them became not significant at 2 years after infection among nonhospitalized and hospitalized individuals, respectively. Cumulatively at 2 years, PASC contributed 80.4 (95% confidence interval (CI): 71.6–89.6) and 642.8 (95% CI: 596.9–689.3) disability-adjusted life years (DALYs) per 1,000 persons among nonhospitalized and hospitalized individuals. | |||||||||||||||||||||
191 | Dark Side of the COVID-19 Pandemic; ‘Long COVID’ | 2023-09-01 | https://doi.org/10.36519/idcm.2023.213 | Elif Mukime Sarıcaoğlu | https://www.idcmjournal.org/long-covid | A total of 1301 patients were included in our study. Two hundred fifty-seven (19.8%) patients were defined as ‘long COVID’ with the presence of ≥1 symptom persisting ≥3 months after COVID-19. The most commonly observed symptoms among patients with ‘long COVID’ were myalgia (14.3%), arthralgia (14.1%), and back pain (13.8%). When the participants with or without ‘long COVID’ were compared, there was no significant difference between the two groups in terms of age and COVID-19 severity. | |||||||||||||||||||||
192 | Determinants of the onset and prognosis of the post-COVID-19 condition: a 2-year prospective observational cohort study | 2023-09-04 | https://doi.org/10.1016/j.lanepe.2023.100724 | Lourdes Mateu | https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(23)00143-6/fulltext | Preexisting medical and socioeconomic factors, as well as acute COVID-19 symptoms, are associated with the development of and recovery from the PCC. Recovery is extremely rare during the first 2 years, posing a major challenge to healthcare systems. Only 26 subjects (7.6%) recovered from PCC during follow-up; almost all of them (n = 24) belonged to the less symptomatic cluster A, dominated mainly by fatigue. | |||||||||||||||||||||
193 | Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19 | 2023-09-09 | https://doi.org/10.1111/apa.16966 | Costanza Di Chiara | https://onlinelibrary.wiley.com/doi/10.1111/apa.16966 | The overall excess risk for new-onset conditions after COVID-19 was 78% higher in the exposed than unexposed children. We found significantly higher risks for some new conditions in exposed children, including mental health issues (aHR 1.8, 95% CI 1.1–3.0) and neurological problems (aHR 2.4, 95% CI 1.4–4.1). | |||||||||||||||||||||
194 | Exacerbation of Pre-Existing Chronic Pain in Older Adults After SARS-CoV-2 Infection: A Single-Center, Cross-Sectional, Observational Study | 2023-09-12 | https://doi.org/10.2147/JPR.S395042 | Wang C | https://www.dovepress.com/exacerbation-of-pre-existing-chronic-pain-in-older-adults-after-sars-c-peer-reviewed-fulltext-article-JPR | Our study observed a prevalence of 21.5% exacerbation of pre-existing chronic pain after SARS-CoV-2 infection, with a consequence of poor quality of life, more severe anxiety and depression.Ninety-five (95/441, 21.5%) older adults suffered from exacerbated chronic pain with a median numerical rating scale (NRS) score of 6 (4– 7) on a median duration of 4.9 (4.3– 5.6) months after SARS-CoV-2 infection. More participants were not vaccinated against COVID-19 (46.5%, 40/86 vs 26.1%, 86/330, P < 0.001) in exacerbation group. | |||||||||||||||||||||
195 | Prevalence of Musculoskeletal, Neurological and Physical Disorder After COVID-19 in Saudi Arabia: A Cross Sectional Study | 2023-09-13 | https://doi.org/10.12688/f1000research.109007.3 | Hayam Mahmoud | https://pubmed.ncbi.nlm.nih.gov/39281329/ | The findings highlighted and concluded that COVID-19 infection had an impact on respiratory, nervous, musculoskeletal systems and affect daily activities. The overall prevalence of neurological and musculoskeletal disorders as follows: headache (63.1%), muscle ache or weakness (62.3%), vertigo (25%), concentration problems (21.8%), breathing troubles (20.4%), loss of balance (19.4%), seizure (1%), and Guillain-Barre Syndrome (0.6%). | |||||||||||||||||||||
196 | Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study | 2023-09-22 | https://doi.org/10.1016/S2213-2600(23)00262-X | The C-MORE/PHOSP-COVID Collaborative Group | https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00262-X/fulltext | Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge... Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9). Compared with controls, patients were more likely to have MRI evidence of lung abnormalities, brain abnormalities, and kidney abnormalities, whereas cardiac and liver MRI abnormalities were similar between patients and controls. | |||||||||||||||||||||
197 | The Predictors of Long COVID in Southeastern Italy | 2023-09-29 | https://doi.org/10.3390/jcm12196303 | Vitaliano Nicola Quaranta | https://www.mdpi.com/2077-0383/12/19/6303 | A total of 71.8% of patients (313) developed Long COVID, while the remaining 123 (28.3%) had a complete remission of symptoms 3 months after acute infection. Dyspnea was the most prevalent symptom, affecting 52.3% of patients, followed by asthenia (32.3%), myalgia (14.7%), insomnia (11.7%), low mood (10.3%), memory impairment (9.4%), headache (6.4%), cough (10.3%), alopecia (4.1%), anosmia (3.0%), and ageusia (3.4%). | |||||||||||||||||||||
198 | Structural and functional impairments of skeletal muscle in patients with postacute sequelae of SARS-CoV-2 infection | 2023-10-01 | https://doi.org/10.1152/japplphysiol.00158.2023 | Marta Colosio | https://pubmed.ncbi.nlm.nih.gov/37675472/ | Several months after mild acute SARS-CoV-2 infection, a substantial proportion of patients present persisting, and often debilitating, symptoms and sequelae. These patients show reduced quality of life due to exercise intolerance, muscle weakness, and fatigue. In our cohort of patients with PASC, we showed limited exercise tolerance mainly due to "peripheral" determinants. Substantial reductions were observed for biomarkers of mitochondrial function, content, and biogenesis. | |||||||||||||||||||||
199 | Association of COVID-19 with respiratory syncytial virus (RSV) infections in children aged 0–5 years in the USA in 2022: a multicentre retrospective cohort study | 2023-10-13 | https://doi.org/10.1136%2Ffmch-2023-002456 | Lindsey Wang | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582888/ | COVID-19 was associated with a significantly increased risk for RSV infections among children aged 0–5 years in 2022. Similar findings were replicated for a study population of children aged 0–5 years in 2021. Our findings suggest that COVID-19 contributed to the 2022 surge of RSV cases in young children through the large buildup of COVID-19-infected children and the potential long-term adverse effects of COVID-19 on the immune and respiratory system. | |||||||||||||||||||||
200 | Aberrant neutrophil degranulation in hospitalized patients with COVID-19 partially remains for 6 months | 2023-10-18 | https://doi.org/10.1002/eji.202350404 | Florianne M.J. Hafkamp | https://onlinelibrary.wiley.com/doi/10.1002/eji.202350404 | These findings show that patients hospitalized due to COVID-19, but not nonhospitalized patients, demonstrated an aberrant neutrophil phenotype, degranulation, CXCL8 release, and ROS generation that partially persists up to 6 months after infection. | |||||||||||||||||||||
201 | SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration | 2023-10-18 | https://doi.org/10.1111/joim.13719 | Alex Qinyang Liu | https://onlinelibrary.wiley.com/doi/10.1111/joim.13719 | SARS-CoV-2 infection is associated with increased incidence of urinary retention, haematuria, UTI and the addition of combination therapy in the short term, regardless of COVID-19 severity. There are no statistically significance differences in incidence of retention, haematuria, or addition of 5ARI across different COVID-19 severities. | |||||||||||||||||||||
202 | Estimating the economic burden of long-Covid: the additive cost of healthcare utilisation among COVID-19 recoverees in Israel | 2023-10-18 | https://doi.org/10.1136/bmjgh-2023-012588 | Yael Wolff Sagy | https://gh.bmj.com/content/8/7/e012588 | Long-term effects of SARS-CoV-2 infections translate into excess healthcare costs, months after recovery, hence requiring adjustments of funds allocation. These excess costs gradually diminish after recoveree, returning to baseline differences 16 months after recoveree. The mean monthly cost incurred by CHS per COVID-19 recoverees over up to 15 months (mean: 8.25) of post-COVID-19 follow-up was higher by 8.2% (US$8.2) compared with matched controls. | |||||||||||||||||||||
203 | Is Recovery Just the Beginning? Persistent Symptoms and Health and Performance Deterioration in Post-COVID-19, non-hospitalised University Students - A Cross-Sectional Study | 2023-10-21 | https://doi.org/10.1101/2023.10.20.23297203 | Ashkan Latifi | https://www.medrxiv.org/content/10.1101/2023.10.20.23297203v1 | Beyond the two-year mark, physical health and error rate continued to improve, while mental health began to deteriorate. Fatigue and reaction time continued to decline. Overall, our findings suggest that some effects of contracting COVID-19 can persist or even deteriorate over time, even in younger individuals who had mild cases that did not require hospitalization. | |||||||||||||||||||||
204 | Impact of COVID-19 on sperm quality and the prostaglandin and polyamine systems in the seminal fluid | 2023-10-24 | https://doi.org/10.1111/andr.13548 | María Eugenia Matzkin | https://onlinelibrary.wiley.com/doi/10.1111/andr.13548 | In both groups of semen samples from coronavirus disease 2019 recovered men (1–6 months and 7–30 months post SARS-CoV-2 infection), sperm vitality, total and progressive sperm motility, and putrescine levels were significantly decreased when compared with samples from the uninfected group. Our work provides insights into the detrimental impact of coronavirus disease 2019 on several sperm parameters, in some cases, even more than a year after SARS-CoV-2 infection. | |||||||||||||||||||||
205 | Long-term health impacts of COVID-19 among 242,712 adults in England | 2023-10-24 | https://doi.org/10.1038/s41467-023-41879-2 | Christina J. Atchison | https://www.nature.com/articles/s41467-023-41879-2 | In our study population, one in 10 people with symptomatic SARS-CoV-2 infection report symptoms for more than 4 weeks, one in 13 for more than 12 weeks, and 1 in 20 for more than 52 weeks. In our study population, 69% of those with persistent symptoms at 12 weeks still had symptoms at 52 weeks, meaning that 31% recovered within a year. | |||||||||||||||||||||
206 | SARS-CoV-2 Affects Thyroid and Adrenal Glands: An 18F-FDG PET/CT Study | 2023-10-26 | https://doi.org/10.3390/biomedicines11112899 | Chiara Lauri | https://www.mdpi.com/2227-9059/11/11/2899 | In our series, we observed persistent low 18F-FDG uptake in adrenal glands of patients at diagnosis of COVID-19 and after recovery, suggesting a chronic hypofunction. By contrast, thyroid uptake was comparable to normal subjects at disease onset, but after recovery, a subgroup of patients showed an increased metabolism, thus possibly suggesting the onset of an inflammatory thyroiditis. | |||||||||||||||||||||
207 | Comparison of testosterone, FSH, LH and E2 hormone levels in infertility suspected males with COVID-19 infection | 2023-10-27 | https://doi.org/10.1097%2FMD.0000000000035256 | Ebru Gökalp Özkorkmaz | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615395/ | COVID-19 is a viral disease that affects organ including gonads. COVID-19 infection decreased testosterone levels and increased E2 levels, which leading to disorders in male and female reproductivity. | |||||||||||||||||||||
208 | Long-term Prognosis at 1.5 years after Infection with Wild-type strain of SARS-CoV-2 and Alpha, Delta, as well as Omicron Variants | 2023-10-29 | https://doi.org/10.1016/j.ijid.2023.10.022 | Jane Agergaard | https://www.ijidonline.com/article/S1201-9712(23)00760-9/fulltext#%20 | Patients infected with Omicron and Delta variants presented with more severe long COVID. At 1.5 year after infection, patients had no clinically meaningful decline in severity of long COVID, and 57% of patients failed to improve 1.5 years after infection, with no differences between variants. Patients infected with Omicron may experience severe non-improving long COVID. | |||||||||||||||||||||
209 | Peculiarities of clinical signs, course and treatment of musculoskeletal system lesions in post-COVID syndrome | 2023-10-31 | https://doi.org/10.5114/reum/172575 | Larysa Voloshyna | https://reu.termedia.pl/Peculiarities-of-clinical-signs-course-and-treatment-of-musculoskeletal-system-lesions,172575,0,2.html | Experiencing acute moderate COVID-19 infection contributes to the occurrence of a long-term unfavorable inflammatory, metabolic and autoimmune response, manifested during the post-COVID period by clinical signs of arthralgia, myalgia and arthritis. Musculoskeletal system lesions in patients with PCS were found to appear 1–4 weeks after the experienced acute period of COVID-19 infection. Against the background of significant arthralgia (100%) in 93 (65.5%) patients manifestations of acute arthritis were detected, the frequency of which increased with age. | |||||||||||||||||||||
210 | Long-Term Health Care Costs Following COVID-19: Implications for Pandemic Preparedness | 2023-11-01 | https://doi.org/10.37765/ajmc.2023.89452 | Laura C. Chambers | https://www.ajmc.com/view/long-term-health-care-costs-following-covid-19-implications-for-pandemic-preparedness | Among commercial members, from the baseline period to the post period, total health care spend increased $41.61 (7.7%) per member per month (PMPM) more among COVID-19 cases compared with their matched controls. Among Medicare Advantage members, the difference-in-differences was greater, with spend increasing $97.30 (13.1%) PMPM more among cases compared with controls. COVID-19 diagnosis was associated with excess health care spend PMPM over the subsequent 12 months, highlighting the importance of societal preparations to support individuals’ long-term health care needs following COVID-19 and as a part of future pandemic preparedness. | |||||||||||||||||||||
211 | Prevalence of Depressive Symptoms and correlates Among Individuals Who Self-reported SARS-CoV-2 Infection after Optimizing the COVID-19 Response in China | 2023-11-01 | https://doi.org/10.3389/fpubh.2023.1268799 | Liang-Jia Wei | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1268799/abstract | This study reveals a moderate prevalence of depression symptoms among individuals infected with SARS-CoV-2. Several factors that were associated with depression symptoms, including sleep difficulties (OR, 2.84), chronic diseases (OR, 2.15), inpatient treatment for COVID-19(OR, 3.24), with COVID-19 symptoms more than 13 days(OR, 1.30), re-infection with SARS-CoV-2 (OR, 1.52). | |||||||||||||||||||||
212 | Evaluation of the retina, choroid and optic disc vascular structures in individuals with a history of COVID-19 | 2023-11-02 | https://doi.org/10.1016/j.jfo.2023.10.003 | B. Gedik | https://www.sciencedirect.com/science/article/abs/pii/S0181551223005235?via%3Dihub | In this study, we found statistically significant changes in choriocapillaris blood flow, subfoveal chroidal thickness and retinal nerve fiber layer thickness after COVID-19 infection. | |||||||||||||||||||||
213 | Semen proteomics reveals alterations in fertility-related proteins post-recovery from COVID-19 | 2023-11-09 | https://doi.org/10.3389/fphys.2023.1212959 | Ankita Dash | https://www.frontiersin.org/articles/10.3389/fphys.2023.1212959/full | Our study suggests that the effect of COVID-19 on the male reproductive system persists even after recovery from COVID-19. In addition, these post-COVID-19 complications persist irrespective of the prevalent variants or vaccination status. | |||||||||||||||||||||
214 | SARS-CoV-2 and the DNA damage response | 2023-11-10 | https://doi.org/10.1099/jgv.0.001918 | Roger J. Grand | https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001918 | It is now becoming clear that the virus causes damage to cellular DNA, as shown by the presence of micronuclei, DNA repair foci and increased comet tails in infected cells. The effects of SARS-CoV-2 on the host genome and on the cellular DDR (DNA damage responses) are comparable to those seen with other RNA and DNA viruses. Infection with the RNA viruses HIV-1, HTLV-1 (human T-lymphotropic virus) and HCV (hepatitis C) generates ROS (reactive oxygen species), which can cause DNA damage. A point of some concern may be whether SARS-CoV-2 virus or viral proteins and/or RNA persist in patients suffering from long COVID and whether these could cause genome instability over the longer term. If this were the case, a rise in cancer cases might be seen in future. | |||||||||||||||||||||
215 | Impact on Hearing Among SARS COV-2 Infected Adults and Children Born to Gestational COVID-19 Infected Mothers: A Prospective Case Control Study | 2023-11-17 | https://doi.org/10.1007/s12070-023-04304-0 | Balaji Swaminathan | https://link.springer.com/article/10.1007/s12070-023-04304-0 | 40% (n = 20) born to COVID-19 infected mothers had OAE (Otoacoustic Emissions) as “Refer”. BERA (Brainstem Evoked Response Audiometry) testing of that OAE "Refer" children revealed 30% (n = 6) hearing impairment. COVID-19 infection cause transient type of high frequency sensory neural hearing loss in adults. Whereas in children born to COVID-19 infected mothers there is risk of developing permanent, progressive or long-standing transient type of sensory neural hearing loss. | |||||||||||||||||||||
216 | Is SARS-CoV-2-induced disease a decisive factor influencing testosterone in males? Findings from a case-control ex post facto study | 2023-11-20 | https://doi.org/10.1111/andr.13558 | Paolo Capogrosso and Alessandro Bertini | https://onlinelibrary.wiley.com/doi/10.1111/andr.13558 | This case-control ex post facto study showed lower tT levels (total testosterone) in men with COVID-19 compared to those without COVID-19 despite both groups have been equally admitted to ICU for severe ARDS (acute respiratory distress syndrome), thus suggesting a possible direct impact of SARS-CoV-2 infection toward circulating tT levels and a consequent more severe clinical outcome. | |||||||||||||||||||||
217 | Prevalence, Clinical Characteristics and Risk Factors of Post-COVID-19 Condition in a Multicenter Pediatric Primary and Hospital Care Cohort | 2023-11-20 | https://doi.org/10.1097/INF.0000000000004188 | Gatell, Anna MD | https://journals.lww.com/pidj/fulltext/9900/prevalence,_clinical_characteristics_and_risk.648.aspx | Our results show that a notable proportion of children and adolescents had persistent symptoms for more than 12 weeks. We describe a cohort of 244 children diagnosed with COVID-19 and followed up for 6 months, in which 4.9% of patients had persistent symptoms at 12 weeks. | |||||||||||||||||||||
218 | Long COVID in Icelandic Children: A Matched Cohort Study of Nonspecific Symptoms Following SARS-CoV-2 Infection | 2023-11-22 | https://doi.org/10.1097/INF.0000000000004187 | Thors, Valtyr | https://journals.lww.com/pidj/fulltext/9900/long_covid_in_icelandic_children__a_matched_cohort.651.aspx | Children who had been infected with SARS-CoV-2 were more likely to report one or more symptoms, except for anxiety/depression and sleep disturbances. Fatigue and loss of concentration were evidently more common in cases among teenagers (risk difference: 15%; 95% CI: 7–22% and 15%; 95% CI: 7–23%, respectively). At the second follow-up, close to a third of Long COVID cases had resolved but some participants had developed new persistent symptoms. | |||||||||||||||||||||
219 | Long COVID in Icelandic Children: A Matched Cohort Study of Nonspecific Symptoms Following SARS-CoV-2 Infection | 2023-11-22 | https://doi.org/10.1097/INF.0000000000004187 | Thors, Valtyr MD, PhD | https://journals.lww.com/pidj/fulltext/9900/long_covid_in_icelandic_children__a_matched_cohort.651.aspx | Symptoms of Long COVID in children are common and impact their quality of life. Children who had been infected with SARS-CoV-2 were more likely to report one or more symptoms, except for anxiety/depression and sleep disturbances. At the second follow-up, close to a third of Long COVID cases had resolved but some participants had developed new persistent symptoms. | |||||||||||||||||||||
220 | Prolonged Gastrointestinal Manifestations After Recovery From COVID-19 | 2023-11-22 | https://doi.org/10.1016/j.cgh.2023.11.009 | B Joseph Elmunzer | https://pubmed.ncbi.nlm.nih.gov/37995983/ | In this follow-up survey of patients 12-18 months after hospitalization with COVID-19, there was a high prevalence of DGBIs (disorders of gut-brain interaction) and persistent GI symptoms. Among patients who experienced COVID-related GI symptoms during the index hospitalization (abdominal pain, nausea, vomiting, or diarrhea), 42.1% retained at least 1 of these symptoms at follow-up; in comparison, 89.8% of respondents retained any (GI or non-GI) COVID-related symptom. | |||||||||||||||||||||
221 | COVID-19 Related Changes in Corneal Curvature and Endothelium after Mild Infection | 2023-11-26 | https://doi.org/10.1016/j.pdpdt.2023.103899 | Fatma SÜMER | https://www.sciencedirect.com/science/article/abs/pii/S1572100023006269 | Endothelial parameters changed more than the changes in corneal curvature and ocular biometric measurements after mild COVID-19. The decrease in endothelial cell number and hexagonality and increase in polymorphism after COVID-19 were striking. The Spherical Equivalant (SE) values showed significant myopic progression after COVID-19 (p<0.001). | |||||||||||||||||||||
222 | The lingering symptoms of post-COVID-19 condition (long-COVID): a prospective cohort study | 2023-11-26 | https://doi.org/10.1111/imj.16251 | Anna J. G. Pryor | https://onlinelibrary.wiley.com/doi/10.1111/imj.16251 | At 3 months after COVID-19, 66.8% reported symptoms, and 44.8% were still experiencing symptoms at 12 months. Fatigue was most common at every point (between 53.1% and 33.1%). Pain symptoms increased in relative prevalence over time, whereas respiratory/pulmonary-type symptoms decreased substantially after 3 months. Long-term COVID-19 symptoms exist among recovered patients up to 12 months after contracting the virus. Fatigue is a primary contributor, while chronic pain became more problematic after 6 months. Vaccination was a factor in preventing long-term symptoms and aiding faster recovery from symptoms. | |||||||||||||||||||||
223 | Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regions | 2023-11-28 | https://doi.org/10.1186/s12889-023-17258-3 | Kentaro Matsui | https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-17258-3 | Participants with COVID-19 had lower SRH (Self-Rated Health) scores than non-infected participants, and those with more severe COVID-19 had a tendency towards even lower SRH scores. In a multivariate regression analysis of participants who had experienced COVID-19, both decreased and increased habitual sleep duration after infection were significantly associated with lower SRH. | |||||||||||||||||||||
224 | Male Hypogonadism After Recovery from Acute COVID-19 Infection: A Prospective Observational Study | 2023-12-04 | https://doi.org/10.1055/a-2201-8816 | Aravind Prasad | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2201-8816 | Low testosterone was detected in 21 (24.71%) and low inhibin-B was detected in 14 (19.71%) out of 71 subjects at 3 months. The severity of COVID-19 infection, duration of hospitalization, and other factors were not significantly associated with low testosterone. At 12 months, 18 out of 21 subjects came for follow-up, of which 9 (50%) showed persistently low testosterone, suggestive of hypogonadism. | |||||||||||||||||||||
225 | Long COVID is associated with severe cognitive slowing | 2023-12-04 | https://doi.org/10.1101/2023.12.03.23299331 | Sijia Zhao PhD, | https://www.medrxiv.org/content/10.1101/2023.12.03.23299331v1 | Together, these results robustly demonstrate pronounced cognitive slowing in people with PCC, which distinguishes them from age-matched healthy individuals who previously had symptomatic COVID-19 but did not manifest PCC (Post-COVID Conditions). | |||||||||||||||||||||
226 | Comparison of post-acute sequelae following hospitalization for COVID-19 and influenza | 2023-12-05 | https://doi.org/10.1186/s12916-023-03200-2 | Ting-Hui Liu | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03200-2 | The COVID-19 group had a higher incidence of any post-COVID-19 condition when compared with the influenza group (17.9% vs. 13.0%), with a hazard ratio (HR) of 1.398. Compared to the influenza group, the COVID-19 group had a significantly higher incidence of abnormal breathing (HR, 1.506), abdominal symptoms (HR, 1.313), fatigue (HR, 1.486), and cognitive symptoms (HR, 1.815). Moreover, the COVID-19 group had a significantly higher risk of the composite outcomes during all-cause ED visits, hospitalizations, and deaths when compared with the influenza group (HR, 1.303). | |||||||||||||||||||||
227 | Rates of ICD-10 Code U09.9 Documentation and Clinical Characteristics of VA Patients With Post–COVID-19 Condition | 2023-12-08 | https://doi.org/10.1001/jamanetworkopen.2023.46783 | Pandora L. Wander | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812721 | In this cohort study of 388 980 US veterans with positive test results for SARS-CoV-2 during the Omicron era (October 1, 2021, to January 31, 2023), 5% had U09.9 documentation by 12 months after infection, (NOTE: U09.9 is the ICD-10-CM code to codify Long COVID, but it isn;t being used as thoroughly as it should be by healthcare providers: "Marked differences by geographic region and facility in U09.9 code documentation may reflect local screening and care practices..") | |||||||||||||||||||||
228 | Post-COVID syndrome and work ability 9-12 months after a SARS-CoV-2 infection among over 9000 employees from the general population | 2023-12-10 | https://doi.org/10.1016/j.ijregi.2023.11.015 | Stefanie Braig | https://www.sciencedirect.com/science/article/pii/S2772707623001236 | In 9752 employees, 13.1% were regarded as having low mWAI (modified work ability index) compared to pre-infection. Outpatient medical treatment, inpatient treatment, and admission to intensive care during infection were associated with mWAI <15th percentile (P15, each odds ratio [OR] >3.0). Post-COVID symptom clusters most strongly linked to mWAI <P15 were neurocognitive impairment and fatigue. | |||||||||||||||||||||
229 | Prevalence of covid-19 and long covid in collegiate student athletes from spring 2020 to fall 2021: a retrospective survey | 2023-12-13 | https://doi.org/10.1186/s12879-023-08801-z | Daisy Massey | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08801-z | About 4% of student athletes who tested positive from spring 2020 to spring 2021 developed Long COVID, defined as new, recurring, or ongoing physical or mental health consequences occurring 4 or more weeks after SARS-CoV-2 infection.This study highlights that Long COVID occurs among young, healthy athletes and is a real consequence of COVID-19. | |||||||||||||||||||||
230 | Risk of newly diagnosed interstitial lung disease after COVID-19 and impact of vaccination: A nationwide population-based cohort study | 2023-12-13 | https://doi.org/10.3389/fpubh.2023.1295457 | Bo-Guen Kim | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1295457/abstract | Participants diagnosed with COVID-19 had a higher risk of ILD (interstitial lung disease) (adjusted hazard ratio [aHR], 11.01; 95% confidence interval [CI], 7.42-16.32) than subjects without COVID-19. In study 2, participants in the vaccination cohort had a lower risk of newly diagnosed ILD than their PS-matched controls (aHR, 0.44; 95% CI, 0.34-0.57). | |||||||||||||||||||||
231 | Persistence of Post-COVID Symptoms in the General Population Two Years After SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis | 2023-12-13 | https://doi.org/10.1016/j.jinf.2023.12.004 | Cesar Fernandez-de-las-Peñas | https://www.sciencedirect.com/science/article/pii/S016344532300590X | This meta-analysis shows the presence of post-COVID symptoms in 30% of patients two-years after COVID-19. Fatigue, cognitive disorders, and pain were the most prevalent post-COVID symptoms. Psychological disturbances as well as sleep problems were still present two-years after COVID-19. | |||||||||||||||||||||
232 | Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study | 2023-12-14 | https://doi.org/10.1016/S1473-3099(23)00684-9 | Yan Xie, PhD | https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00684-9/fulltext | Over 18 months of follow-up, compared to seasonal influenza, the COVID-19 group had an increased risk of death (hazard ratio [HR] 1·51 [95% CI 1·45–1·58]), corresponding to an excess death rate of 8·62 (95% CI 7·55–9·44) per 100 persons in the COVID-19 group versus the influenza group. Compared to seasonal influenza, COVID-19 also had an increased risk of hospital readmission (excess rate 20·50 [95% CI 16·10–24·86] per 100 persons) and admission to intensive care (excess rate 9·23 [6·68–11·82] per 100 persons). | |||||||||||||||||||||
233 | Post-COVID changes in lung function 6 months after veno-venous extracorporeal membrane oxygenation: a prospective observational clinical trial | 2023-12-20 | https://doi.org/10.3389/fmed.2023.1288679 | Alexandra Pálfi | https://www.frontiersin.org/articles/10.3389/fmed.2023.1288679/full | Severe acute COVID-19 requiring V-V ECMO persistently impairs small airway function and reduces respiratory tissue elasticity, primarily attributed to lung restriction. These findings also suggest that even severe pulmonary pathologies of acute COVID-19 can manifest in a moderate but still persistent lung function impairment 6 months after hospital discharge. | |||||||||||||||||||||
234 | Long COVID patients continue to experience significant symptoms at 12 months and factors associated with improvement: a prospective cohort study in France (PERSICOR) | 2023-12-22 | https://doi.org/10.1016/j.ijid.2023.11.038 | Dominique Salmon | https://www.sciencedirect.com/science/article/pii/S1201971223007981 | At 12-months, only 8.7% (95% CI: 5.4%-13.1%). reported complete remission, while 28.6% noted significant improvement. Most symptoms remained prevalent: asthenia (83.1%), neurocognitive/neurological (93.9%), cardiothoracic (77.9%), Musculoskeletal (78.8%). During long COVID, 62.2% stopped working, and only 32.5% resumed full-time professional activities. | |||||||||||||||||||||
235 | Long-term reduced functional capacity and quality of life in hospitalized COVID-19 patients | 2023-12-27 | https://doi.org/10.3389/fmed.2023.1289454 | Anderson D. da Silveira | https://www.frontiersin.org/articles/10.3389/fmed.2023.1289454/abstract | Hospitalized COVID-19 patients presented, 7 months after discharge, with a reduction in functional capacity and HRQoL (health-related quality of life) when compared to historical controls. HRQoL were reduced and correlated with the reduced peak VO2 in our population. | |||||||||||||||||||||
236 | Differences in Report of Post-COVID Conditions Among Adults Tested for SARS-CoV-2 by Race and Ethnicity—2022 Porter Novelli SummerStyles Survey, United States | 2023-12-27 | https://doi.org/10.1016/j.focus.2023.100181 | Leora R. Feldstein | https://www.sciencedirect.com/science/article/pii/S2773065423001189 | 57% of respondents with positive SARS-CoV-2 tests reported ≥1 ongoing symptom, compared to 22% of respondents who tested negative. Also, it finds significant differences based on race. Hispanic respondents had significantly higher odds ratios of experiencing two or more ongoing symptoms (aOR: 2.03), respiratory/cardiac symptoms (aOR: 1.47), and neurological symptoms (aOR: 1.77) compared to non-Hispanic White respondents. | |||||||||||||||||||||
237 | Muscle abnormalities worsen after post-exertional malaise in long COVID | 2024-01-04 | https://doi.org/10.1038/s41467-023-44432-3 | Brent Appelman | https://www.nature.com/articles/s41467-023-44432-3 | We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. | |||||||||||||||||||||
238 | Incidence of persistent SARS-CoV-2 gut infection in patients with a history of COVID-19: Insights from endoscopic examination | 2024-01-05 | https://doi.org/10.1055%2Fa-2180-9872 | Mohamed Hany | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769582/ | Endoscopic biopsies were prospectively collected from patients with previous COVID-19 infection undergoing upper or lower gastrointestinal endoscopy (UGE or LGE). The incidence of positive immunostaining was significantly higher in UGE biopsies than in LGE biopsies (37.34% vs. 16.87%, P =0.002). Gut mucosal tissues can act as a long-term reservoir for SARS-CoV-2, retaining viral particles for months following the primary COVID-19 infection. Smokers and individuals with diabetes may be at an increased risk of persistent viral gut infection. | |||||||||||||||||||||
239 | Prevalence of depressive symptoms and correlates among individuals who self-reported SARS-CoV-2 infection after optimizing the COVID-19 response in China | 2024-01-08 | https://doi.org/10.3389/fpubh.2023.1268799 | Liangjia Wei | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1268799/full | The prevalence of depression symptoms was 35.3%. More than 40% of participants reported that they had missed healthcare appointments or delayed treatment. Logistic regression analysis revealed several factors that were associated with depression symptoms, including sleep difficulties (OR, 2.84; 95% CI, 2.34–3.44), chronic diseases (OR, 2.15; 95% CI, 1.64–2.82), inpatient treatment for COVID-19 (OR, 3.24; 95% CI, 2.19–4.77), with COVID-19 symptoms more than 13 days (OR, 1.30, 95% CI 1.04–1.63), re-infection with SARS-CoV-2 (OR, 1.52; 95% CI, 1.07–2.15), and the increased in demand for healthcare services (OR, 1.32; 95% CI, 1.08–1.61). | |||||||||||||||||||||
240 | Persistent Risk of Developing Autoimmune Diseases Associated With COVID-19 | 2024-01-08 | https://doi.org/10.1097/RHU.0000000000002054 | Inokuchi, Shoichiro | https://journals.lww.com/jclinrheum/fulltext/9900/persistent_risk_of_developing_autoimmune_diseases.179.aspx | COVID-19 is associated with an increased risk of developing autoimmune diseases in the Japanese population, and this effect persists for a long time. The relative risk of any autoimmune disease was 2.32 (95% confidence interval, 2.08–2.60). All the investigated outcomes showed a significant risk associated with COVID-19. Several autoimmune diseases exhibit a risk associated with COVID-19 in the short to long term, and the long-term risk is substantial for systemic sclerosis and immunoglobulin G4–related disease. | |||||||||||||||||||||
241 | Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study | 2024-01-09 | https://doi.org/10.1038/s41598-023-50024-4 | Yoonjung Kim | https://www.nature.com/articles/s41598-023-50024-4 | Quality of life improved over time for the participants, but 32.2% of respondents still reported anxiety/depression at the end of the study. Overall, our cohort demonstrates that long COVID can persist up to 24 months after COVID-19 infection, affecting mental health and quality of life. | |||||||||||||||||||||
242 | The characteristics of acute macular neuroretinopathy following COVID-19 infection | 2024-01-10 | https://doi.org/10.1186/s12886-024-03283-2 | Hui Feng | https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-024-03283-2 | During follow-up (average 12.5 weeks), partial improvement in retinal lesions was observed in NIR imaging and SD-OCT in some patients, but a proportion of patients still exhibited persistent retinal damage and no improvement in visual field scotomas. COVID-19-related AMN (acute macular neuroretinopathy) share similar clinical and imaging features with AMN due to other causes, as evidenced by the persistent presence of visual field scotomas over a longer duration. | |||||||||||||||||||||
243 | Risks of digestive diseases in long COVID: evidence from a population-based cohort study | 2024-01-10 | https://doi.org/10.1186/s12916-023-03236-4 | Yuying Ma | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03236-4 | COVID-19 patients are at a higher risk of developing digestive diseases. The risks exhibited a stepwise escalation with the severity of COVID-19, were noted in cases of reinfection, and persisted even after 1-year follow-up. The risks of GERD were increased stepwise with the severity of the acute phase of COVID-19 infection. Even after 1-year follow-up, GERD (HR 1.64 (1.30 to 2.07)) and GI dysfunction (HR 1.35 (1.04 to 1.75)) continued to pose risks to COVID-19 patients. Compared to those with one SARS-CoV-2 infection, reinfected patients were at a higher risk of pancreatic diseases (HR 2.57 (1.23 to 5.38)). | |||||||||||||||||||||
244 | Outcomes of SARS-CoV-2 and Seasonal Viruses Among Children Hospitalized in Brazil | 2024-01-12 | https://doi.org/10.1542/peds.2023-064326 | Cristiane S. Dias | https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2023-064326/196412/Outcomes-of-SARS-CoV-2-and-Seasonal-Viruses-Among?autologincheck=redirected | The estimated probability of a fatal outcome at 30 days of hospitalization according to the viral strain was 6.5%, 3.4%, 2.9%, 2.3%, 2.1%, and 1.8%, for SARS-CoV-2, coinfection, adenovirus, influenza, other viruses, and respiratory syncytial virus, respectively. Individuals with a positive test for SARS-CoV-2 had hazard of death 3 times higher than subjects with a negative test (hazard ratio, 3.3; 95% confidence interval, 3.1–3.5). | |||||||||||||||||||||
245 | COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions | 2024-01-15 | https://doi.org/10.1007/s11914-023-00842-2 | Amy Creecy | https://link.springer.com/article/10.1007/s11914-023-00842-2 | SARS-CoV-2 can negatively affect the bone through multiple direct and indirect mechanisms.The early clinical evidence indicates an increase in vertebral fractures, hypocalcemia, vitamin D deficiencies, and a loss in BMD (bone mineral density) among COVID-19 patients. | |||||||||||||||||||||
246 | The prevalence of obstructive sleep apnea syndrome after COVID-19 infection | 2024-01-18 | https://doi.org/10.1002/jmv.29392 | Wen-Chun Lin | https://onlinelibrary.wiley.com/doi/10.1002/jmv.29392 | The COVID-19 group was associated with an increased risk of obstructive sleep apnea, at both 3 months of follow-up (HR: 1.51, 95% CI: 1.48–1.54), and 1 year of follow-up (HR: 1.57, 95% CI: 1.55–1.60). The risks of obstructive sleep apnea among COVID-19 patients were significant in the less than 65 year of age group (HR: 1.50, 95% CI: 1.47–1.52), as well as in the group older than or equal to 65 years (HR:1.69, 95% CI: 1.64–1.73). | |||||||||||||||||||||
247 | SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence | 2024-01-18 | https://doi.org/10.1007/s11914-023-00843-1 | Alexander Harris | https://link.springer.com/article/10.1007/s11914-023-00843-1 | SARS-CoV-2 infection directly and indirectly affects bone health, leading to potential long-term consequences. The disease has been associated with hypocalcemia, altered bone turnover markers, and a high prevalence of VFs (vertebral fractures). The severity of the disease correlates with a decrease in BMD (bone mineral density). | |||||||||||||||||||||
248 | Long-term symptoms after SARS-CoV-2 infection in a cohort of hospital employees: duration and predictive factors | 2024-01-23 | https://doi.org/10.1186/s12879-023-08710-1 | Rosalie Gruber | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08710-1 | About half of the HEs suffered from long lasting symptoms over 90 days after almost entirely mild acute COVID-19. The occurrence of breathlessness within the first ten days (OR 7.89; 95%CI 1.87–41.43; p = 0.008), an initial Ct value under 30 (OR 3.36; 95%CI 1.22–9.94; p = 0.022) as well as the occurrence of anosmia or ageusia within the first ten days (OR 3.01; 95%CI 1.10–8.84; p = 0.037) showed a statistically significant association with increased odds of illness duration over 90 days. | |||||||||||||||||||||
249 | Lung function trajectories in mild COVID-19 with two-year follow-up | 2024-01-25 | https://doi.org/10.1093/infdis/jiae037 | Katrine K Iversen | https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae037/7589572?login=false | Our results indicate that mild COVID-19 infection affects lung function at time of infection with limited recovery two years after infection. Individuals with COVID-19 had an adjusted excess decline in FEV1 (Forced expiratory volume) of 13.0 mL per year (CI 23.5; 2.5), p=0.02 from prior infection to 6 months after infection compared to uninfected controls. From 6 to 24 months after infection, they had an excess decline of 7.5 mL per year (CI 25.6; 9.6), p=0.40. A similar pattern was observed for FVC (Forced vital capacity). | |||||||||||||||||||||
250 | COVID-19-related retinal microvasculopathy and systemic implications in patients with severe disease: results from the Methuselah study | 2024-01-26 | https://doi.org/10.3389/fmed.2024.1294432 | Niccolò Castellino | https://www.frontiersin.org/articles/10.3389/fmed.2024.1294432/full | Retinal vascular alterations were not reversible 12 months after COVID-19 and were linked to inflammation and renal dysfunction during hospitalization as well as to aortic stiffness measured during follow-up. | |||||||||||||||||||||
251 | Long COVID in pediatrics—epidemiology, diagnosis, and management | 2024-01-27 | https://doi.org/10.1007/s00431-023-05360-y | Nicole Toepfner | https://link.springer.com/article/10.1007/s00431-023-05360-y | Pediatric PASC mostly manifest after mild courses of COVID-19 and in the majority of cases remit after few months. However, symptoms can last for more than 1 year and may result in significant disability. Frequent symptoms include fatigue, exertion intolerance, and anxiety. | |||||||||||||||||||||
252 | Analysis of characteristics of and risk factors for otological symptoms after COVID-19 infection | 2024-02-01 | https://doi.org/10.1371/journal.pone.0297100 | Qiang Wang | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0297100 | In total, 106/468 (22.6%) participants experienced tinnitus, 66/468 (14.1%) hearing loss, 103/468 (22.0%) aural fullness, and 71/468 (15.2%) dizziness. The number of vaccine doses was positively associated with the resolution of otological symptoms (P = 0.035). | |||||||||||||||||||||
253 | Increased prevalence of erythema multiforme in patients with COVID-19 infection or vaccination | 2024-02-02 | https://doi.org/10.1038/s41598-024-52099-z | Wafaa Saleh | https://www.nature.com/articles/s41598-024-52099-z | Patients with COVID-19 infection were 6.68 times more likely to have EM than those without COVID-19 (P < 0.0001). Similarly, the risk of developing EM after COVID-19 vaccination was 2.7, significantly higher than the general population (P < 0.0001). | |||||||||||||||||||||
254 | Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative data | 2024-02-02 | https://doi.org/10.1016/j.lana.2024.100688 | Omar Yaxmehen Bello-Chavolla | https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00015-2/fulltext | Persistent symptoms after SARS-CoV-2 infection were reported by 12.44% (95% CI 11.89–12.99) of adults ≥20 years in Mexico in 2022. PASC was present in 21.21% (95% CI 19.74–22.68) of subjects with previously diagnosed COVID-19. Over 28.6% of patients with PASC reported symptoms persistence ≥6 months and 14.05% reported incapacitating symptoms. | |||||||||||||||||||||
255 | Sleep quality among non-hospitalized COVID-19 survivors: a national cross-sectional study | 2024-02-04 | https://doi.org/10.3389/fpubh.2023.1281012 | Huong Thi Xuan Hoang | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1281012/full | Our study highlights the substantial burden of insomnia among non-hospitalized COVID-19 survivors and the significant association of depression and anxiety on the development of this long-term effect of COVID-19.The prevalence of insomnia was 76.1%, and among those, 22.8% of participants scored for severe insomnia. Participants with depressive (OR 3.45; 95%CI 1.87–6.34) or anxiety (OR 3.93; 95%CI 2.52–6.13) had significantly higher odds of developing insomnia. | |||||||||||||||||||||
256 | Persisting exercise ventilatory inefficiency in subjects recovering from COVID-19. Longitudinal Data Analysis 34 Months Post-Discharge Running title: Persisting Exercise Ventilatory Inefficiency in post-COVID Subjects | 2024-02-04 | https://doi.org/10.21203/rs.3.rs-3928238/v1 | Gianluigi Dorelli | https://www.researchsquare.com/article/rs-3928238/v1 | In a longitudinal study on 32 selected post-COVID subjects, we performed two cardiopulmonary exercise tests (CPETs) at 6 months (T0) and 34 months (T1) after hospital discharge. Five subjects (16%) have pEVin (Persising Exercise ventilatory inefficiency) at 34 months.Evef (ventilatory efficiency) subjects demonstrated selective improvements... suggesting recovery in cardiorespiratory function over time. In contrast, those with pEvin did not exhibit these improvements. | |||||||||||||||||||||
257 | Acute kidney injury outcomes of COVID-19 confirmed patients in a Philippine tertiary hospital: A retrospective study | 2024-02-06 | https://doi.org/10.1101/2024.02.05.24302369 | Joberly Sayson | https://www.medrxiv.org/content/10.1101/2024.02.05.24302369v1 | Our study demonstrated that patients with COVID-19 can develop AKI (acute kidney injury) and tend to have a poorer prognosis. Of the 195 patients (hospitalized with COVID), 81(42%) patients developed AKI. Hhigher mortality rates were observed in patients with AKI (50.62%) versus patients without AKI (12.28%). | |||||||||||||||||||||
258 | Cardiopulmonary exercise testing in younger patients with persistent dyspnea following acute, outpatient COVID-19 infection | 2024-02-06 | https://doi.org/10.14814/phy2.15934 | Aaron B. Holley | https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15934 | We sought to determine causes of persistent dyspnea in younger patients recovering from acute COVID-19 infection that did not require hospitalization. CPET data on 45 patients (238.3 ± 124 days post-test positivity) with a median age of 27.0 (22.0–40.0) were available for analysis. All but two (95.6%) were active-duty service members. The group showed substantial loss of aerobic capacity—average VO2 peak (L/min) was 84.2 ± 23% predicted and 25 (55.2%) were below the threshold for normal. Younger active-duty military patients with persistent dyspnea following outpatient COVID-19 infection show a substantial reduction in aerobic capacity that is not driven by structural cardiopulmonary disease. | |||||||||||||||||||||
259 | Association between SARS-CoV-2 infection and select symptoms and conditions 31 to 150 days after testing among children and adults | 2024-02-10 | https://doi.org/10.1186/s12879-024-09076-8 | Yongkang Zhang | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09076-8 | After adjustment for baseline covariates, hospitalized adults and children with a positive test had increased odds of being diagnosed with ≥ 1 symptom (adults: adjusted odds ratio[aOR], 1.17; children: aOR, 1.18) or shortness of breath (adults: aOR, 1.50; children: aOR, 1.40) 31–150 days following a SARS-CoV-2 test compared with hospitalized individuals with a negative test.The risks of being newly diagnosed with type 1 or type 2 diabetes (adjusted hazard ratio[aHR], 1.25), hematologic disorders (aHR, 1.19), or respiratory disease (aHR, 1.44) were higher among hospitalized adults with a positive test compared with those with a negative test. Non-hospitalized adults with a positive test also had higher odds or increased risk of being diagnosed with certain symptoms or conditions. | |||||||||||||||||||||
260 | Impact of COVID-19 on testicular function: a systematic review and meta-analysis | 2024-02-12 | https://doi.org/10.1007/s12020-024-03705-7 | Rossella Cannarella | https://link.springer.com/article/10.1007/s12020-024-03705-7 | The present systematic review and meta-analysis suggests the presence of an association between SARS-CoV-2 infection and primary testicular damage manifested with a picture of altered steroidogenesis and worsening spermatogenesis. Sperm concentration, total sperm count, and total motility were significantly lower in patients compared with controls. | |||||||||||||||||||||
261 | Post-discharge outcomes of hospitalized children diagnosed with acute SARS-CoV-2 or MIS-C | 2024-02-12 | https://doi.org/10.3389/fped.2024.1340385 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10895015/ | Ericka L Fink | https://pubmed.ncbi.nlm.nih.gov/38410766/ | One-third [23/79 (29.1%)] were not recovered at follow-up [43 (31, 54) months post-discharge]. At follow-up, 67% overall had new or persistent symptoms. Forty percent had at least one return emergency visit and 24% had a hospital readmission. | ||||||||||||||||||||
262 | Estimates of Incidence and Predictors of Fatiguing Illness after SARS-CoV-2 Infection | 2024-02-14 | https://doi.org/10.3201/eid3003.231194 | Quan M. Vu | https://wwwnc.cdc.gov/eid/article/30/3/23-1194_article#:~:text=COVID%2D19%20patients%20had%201.68,chronic%20fatigue%20than%20did%20controls. | Among COVID-19 patients (15% hospitalized for acute COVID-19), the incidence rate of fatigue was 10.2/100 person-years and the rate of chronic fatigue was 1.8/100 person-years. Compared with non–COVID-19 controls, the hazard ratios were 1.68 (95% CI 1.48–1.92) for fatigue and 4.32 (95% CI 2.90–6.43) for chronic fatigue. | |||||||||||||||||||||
263 | Long-term effects of SARS-CoV-2 infection in hospitalized children: findings from an Italian single-center study | 2024-02-14 | https://doi.org/10.1186/s13052-024-01596-y | Valeria Calcaterra | https://ijponline.biomedcentral.com/articles/10.1186/s13052-024-01596-y | This study underscores that long COVID is a significant concern in the pediatric population. We included 167 patients (77 F/90 M). 19 patients (16.5%) reported experiencing at least one symptom indicative of Long COVID (weight loss 31.6%, inappetence 26.3%, chronic cough 21.1%, fatigue 21.1%, and sleep disturbances, wheezing, abdominal pain and mood disorders 15.8%). | |||||||||||||||||||||
264 | Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study | 2024-02-15 | https://doi.org/10.3389/fped.2024.1334591 | Mirela Luminița Pavelescu | https://www.frontiersin.org/articles/10.3389/fped.2024.1334591/full | The leukocytes, neutrophils and lymphocytes have significantly lower values in COVID-19 children. | |||||||||||||||||||||
265 | Natural course of post-COVID symptoms in adults and children | 2024-02-16 | https://doi.org/10.1038/s41598-024-54397-y | Aya Sugiyama | https://www.nature.com/articles/s41598-024-54397-y | Upon their initial recovery, the prevalence of post-COVID symptoms was 78·4% in adults and 34·6% in children. Three months later, the rates were 47·6% and 10·8%. After over one year, they were 31·0% and 6·8%. Regarding symptoms interfere with daily life, 304 people (12.6%) experienced symptoms lasting for over three months. There was no significant association between vaccination history and post-COVID symptoms. | |||||||||||||||||||||
266 | Prevalence and Determinants of Long-term Post-COVID Conditions in the United States: 2022 Behavioral Risk Factor Surveillance System | 2024-02-20 | https://doi.org/10.1016/j.amjmed.2024.02.010 | Seyyed Sina Hejazian | https://www.sciencedirect.com/science/article/abs/pii/S0002934324000901 | The overall estimated prevalence of long-term post-COVID conditions among COVID survivors was 21.7%. Fatigue(5.7%), dyspnea(4.2%), and anosmia/ageusia(3.8%) were the most frequent symptoms. Based on multivariate logistic regression analysis, female sex, body mass index (BMI)≥25, lack of insurance, history of pulmonary disease, depression, and arthritis, being a former smoker, and sleep duration<7h/day were associated with higher odds of post-COVID conditions. | |||||||||||||||||||||
267 | Long-COVID Prevalence and Its Association with Health Outcomes in the Post-Vaccine and Antiviral-Availability Era | 2024-02-21 | https://doi.org/10.3390/jcm13051208 | Ramida Jangnin | https://www.mdpi.com/2077-0383/13/5/1208 | Long-COVID prevalence was observed at 77.7%, with the most frequently reported symptoms being fatigue (64.1%) and cough (43.9%). Regarding mental health, depression was reported by 8.2% of the participants, anxiety by 4.1%, and poor sleep quality by 33.3%. Advanced statistical analysis using multivariable logistic regression showed significant links between long-COVID symptoms and patients aged below 60 (p = 0.042), as well as the initial symptom of cough (p = 0.045). | |||||||||||||||||||||
268 | Fatigue and symptom-based clusters in post COVID-19 patients: a multicentre, prospective, observational cohort study | 2024-02-21 | https://doi.org/10.1186/s12967-024-04979-1 | Merel E. B. Cornelissen | https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-04979-1 | According to the FSS (Fatigue Severity Scale), fatigue was reported by 75.9% of the patients at 3–6 months after infection and by 57.1% of the patients 9–12 months later. Post-exertional malaise, sleep disturbances, pain, and neurocognitive symptoms were also frequently reported, according to the DSQ-2. Over half of the patients (52.7%) met the Fukuda criteria for ME/CFS. | |||||||||||||||||||||
269 | Risk and protective factors for Long COVID in Brazilian adults (CUME Study) | 2024-02-21 | https://doi.org/10.3389/fmed.2024.1344011 | Júlio Eduvirgem | https://www.frontiersin.org/articles/10.3389/fmed.2024.1344011/full | Long COVID was observed in 48.9% of the participants. The following characteristics were identified as risk factors for the outcome: female sex (RR = 1.56; 95% CI = 1.22–1.99); prior diagnosis of hypertension (RR = 1.46; 95% CI = 1.19–1.80); having contracted COVID-19 in the first (RR =1.38; 95% CI = 1.07–1.79) or in the second waves (RR = 1.33; 95% CI = 1.07–1.65) of the pandemic period; and having presented three or more signs and symptoms during the acute phase of COVID-19 (RR = 2.99; 95% CI = 1.08–8.24). | |||||||||||||||||||||
270 | Prevalence of persistent SARS-CoV-2 in a large community surveillance study | 2024-02-21 | https://doi.org/10.1038/s41586-024-07029-4 | Mahan Ghafari | https://www.nature.com/articles/s41586-024-07029-4 | Individuals with persistent infection had more than 50% higher odds of self-reporting long COVID than individuals with non-persistent infection. We estimate that 0.1–0.5% of infections may become persistent with typically rebounding high viral loads and last for at least 60 days. | |||||||||||||||||||||
271 | The neurovascular retinal involvement in a large population of patients recovered from COVID-19: an OCT and OCT angiography study | 2024-02-24 | https://doi.org/10.1038/s41433-024-02991-9 | Eleonora Cosmo | https://www.nature.com/articles/s41433-024-02991-9 | A microvascular retinal and choriocapillaris damage may be identified secondary to SARS-CoV-2 infection, even after recovery. VAD (vessel area density) of all the three retinal plexuses... and VD (vessel density) of CC (choriocapillaris ) were significantly reduced in patients versus controls. | |||||||||||||||||||||
272 | The silent reservoir? SARS-CoV-2 detection in the middle ear effusion of patients with Otitis media with effusion after omicron infection | 2024-02-28 | https://doi.org/10.1016/j.amjoto.2024.104229 | Chengzhou Han | https://www.sciencedirect.com/science/article/abs/pii/S0196070924000152 | Our study highlights the potential effects of COVID-19 on the middle ear, suggesting a link between SARS-CoV-2 and OME (Otitis Media with Effusion) onset. The virus, a significant contributor to OME, is detectable in the MEE (Middle Ear Effusion) nearly a month post-Omicron infection | |||||||||||||||||||||
273 | CT-based Assessment at 6-Month Follow-up of COVID-19 Pneumonia patients in China | 2024-02-29 | https://doi.org/10.1038/s41598-024-54920-1 | Xingyu Fang | https://www.nature.com/articles/s41598-024-54920-1 | The 6-month follow-up CT of recent COVID-19 pneumonia cases in China showed a considerable proportion of the patients with pulmonary residual abnormalities and fibrotic-like changes. Pulmonary residual abnormalities and fibrotic-like changes were found in 98 (36.2%) and 39 (14.4%) participants. | |||||||||||||||||||||
274 | Lung abnormalities on computed tomography of Vietnamese patients with COVID-19 and the association with medical variables | 2024-03-01 | https://doi.org/10.1016/j.ijregi.2024.01.006 | Cong Dien Trinh | https://www.sciencedirect.com/science/article/pii/S2772707624000067 | Patients with mild COVID-19 had a similar risk of lung injury as patients with severe COVID-19. Patients with mild and moderate COVID-19 had up to 45% lung injuries, whereas critical patients had 55%. However, patients with mild and moderate COVID-19 typically had low-level lung injuries. Ground-glass (68.1%), consolidation (48.8%), opacity (36.3%), and nodular (6.9%) lung lesions were the most prevalent in patients with COVID-19. | |||||||||||||||||||||
275 | Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study | 2024-03-01 | https://doi.org/10.1016/j.eclinm.2024.102500 | Meijun Meng | https://www.sciencedirect.com/science/article/pii/S2589537024000798 | Our research suggests that patients with COVID-19 may have an increased risk of developing respiratory diseases, and the risk increases with the severity of infection and reinfection. Even during the 24-month follow-up, the risk of asthma and bronchiectasis continued to increase.Compared to those with one SARS-CoV-2 infection, reinfected patients were at a higher risk of asthma (3.0; 1.32–6.84), COPD (3.07; 1.42–6.65), ILD (3.61; 1.11–11.8), and lung cancer (3.20; 1.59–6.45). | |||||||||||||||||||||
276 | Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19 | 2024-03-01 | https://doi.org/10.1038/s41590-024-01754-8 | Aimee L. Hanson | https://www.nature.com/articles/s41590-024-01754-8 | Lymphopenia and low numbers of dendritic cells persisted in those with PASC, and single-cell analysis reported iron maldistribution, suggesting monocyte iron loading and increased iron demand in proliferating lymphocytes. Thus, defects in iron homeostasis, dysregulated erythropoiesis and immune dysfunction due to COVID-19 possibly contribute to inefficient oxygen transport, inflammatory disequilibrium and persisting symptomatology | |||||||||||||||||||||
277 | Impact of COVID-19 versus other pneumonia on in-hospital mortality and functional decline among Japanese dialysis patients: a retrospective cohort study | 2024-03-02 | https://doi.org/10.1038/s41598-024-55697-z | Ken Ikenouchi | https://www.nature.com/articles/s41598-024-55697-z | The multivariable logistic regression analyses revealed greater odds ratios (ORs) of death [5.92 (95% CI 3.62–9.96)] and functional decline [1.93 (95% CI 1.26–2.99)] only in the COVID-19/dialysis group versus the non-COVID-19/non-dialysis group. COVID-19 displayed a greater impact on physical function than other types of pneumonia particularly in ESKD (end-stage kidney disease). | |||||||||||||||||||||
278 | Co-Morbidity Clusters in Post-COVID-19 Syndrome | 2024-03-02 | https://doi.org/10.3390/jcm13051457 | Anna Teréz Sárközi | https://www.mdpi.com/2077-0383/13/5/1457 | The average time between acute episode and post-COVID-19 care was 149 days. Spirometry indicated significant abnormalities in lung function. Predominant symptoms included respiratory (75%), fatigue (73%), neurological (62.5%), and ear-nose-throat issues (51.25%). Multiorgan dysfunctions were observed in 87.5% of patients, contributing to an 18.33% reduction in health quality compared to pre-acute COVID-19 levels. | |||||||||||||||||||||
279 | Increased luminal area of large conducting airways in patients with COVID-19 and post-acute sequelae of COVID-19 A retrospective case-control study | 2024-03-02 | https://doi.org/10.1101/2024.02.29.24303556 | Solomiia Zaremba | https://www.medrxiv.org/content/10.1101/2024.02.29.24303556v1 | Patients diagnosed with COVID-19 and PASC have greater airway luminal area in most large conducting airways compared to healthy controls. No differences in luminal area between patients with COVID-19 and PASC suggest persistence of changes or insufficient time for complete reversal of changes. Airway luminal areas were 12% to 39% larger among PASC patients compared to controls. | |||||||||||||||||||||
280 | Persistent pulmonary abnormalities after 18 months of SARS-CoV-2 pneumoniaAlteraciones pulmonares persistentes tras 18 meses de neumonía por SARS-CoV-2 | 2024-03-04 | https://doi.org/10.1016/j.rxeng.2023.10.002 | C. Valenzuela | https://www.sciencedirect.com/science/article/abs/pii/S2173510724000375 | Pulmonary function 18 months after the acute episode revealed a mean FVC (Forced vital capacity) of 92% of predicted value, with an FVC < 80% of predicted value in 11 patients (35.4%). Mean DLCO (Diffusing capacity for carbon monoxide) was 71% of predicted value, with a DLCO < 80% in 22 patients (70%). Persistent interstitial lung abnormalities are seen on HRCT (High-resolution computed tomography) for a subset of patients infected with SARS-CoV-2 pneumonia. Seventy percent of these patients suffered a slight decrease in DLCO. | |||||||||||||||||||||
281 | Four- and sixteen-month clinical status of a cohort of patients following hospitalization for COVID-19 | 2024-03-04 | https://doi.org/10.1016/j.resmer.2024.101099 | Tài Pham | https://www.sciencedirect.com/science/article/pii/S259004122400014X | Seventy-nine patients (25%) were asymptomatic at four months but declared ≥1 symptom one year later. In patients evaluated twice, the prevalence of cognitive impairment was 45% at four months and 40% at 16 months. Depression and post-traumatic symptoms prevalence remained stable, and the prevalence of anxiety significantly decreased. Dysfunctional breathing was detected in 32% of patients. At 16 months after discharge, lung CT-scan exhibited abnormalities in 30/80 patients (38%), compared to 52/85 patients (61%) at four months. | |||||||||||||||||||||
282 | Symptom trajectories of post-COVID sequelae in patients with acute Delta or Omicron infection in Bergen, Norway | 2024-03-04 | https://doi.org/10.3389/fpubh.2024.1320059 | Arild Iversen | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1320059/full | We followed a cohort of 1,374 non-hospitalized COVID-19 patients in Bergen, Norway, at three time points. Four months post-infection, patients reported increased frequencies of dyspnea (from 15% during acute illness to 25% at 4 months, p < 0.001), cognitive symptoms (from 9 to 32%, p < 0.001) and depression (from 1 to 17%, p < 0.001). Ten percent reported sick leave after acute illness, and vaccination reduced the risk of absenteeism (adjusted risk ratio: 0.36, 95% confidence interval: 0.15, 0.72, p = 0.008). | |||||||||||||||||||||
283 | Long-Term Autoimmune Inflammatory Rheumatic Outcomes of COVID-19 | 2024-03-05 | https://doi.org/10.7326/M23-1831 | Min Seo Kim | https://www.acpjournals.org/doi/10.7326/M23-1831 | After propensity score matching, beyond the first 30 days after infection, patients with COVID-19 were at increased risk for incident AIRD (autoimmune inflammatory rheumatic diseases) compared with uninfected patients (adjusted hazard ratio, 1.25 [95% CI, 1.18 to 1.31]) and influenza-infected control patients (adjusted hazard ratio, 1.30 [CI, 1.02 to 1.59]). The risk for incident AIRD was higher with more severe acute COVID-19. | |||||||||||||||||||||
284 | Gas exchange abnormalities in Long COVID are driven by the alteration of the vascular component | 2024-03-06 | https://doi.org/10.5826/mrm.2024.938 | Gianluca Imeri | https://mrmjournal.org/index.php/mrm/article/view/938 | In conclusion, in COVID-19 survivors who are still symptomatic or have minimal CT impairment at one year, gas exchange abnormalities are determined by the vascular component. This condition may be present despite normal DLCO. Our findings are consistent with previous works, describing systemic capillary impairment in patients with long COVID-19. | |||||||||||||||||||||
285 | The Effect of Sex on the Risk of Long-COVID and Cardiovascular Complications in Healthy Patients without Comorbidities: Data from a Polish Long-COVID Cardiovascular (PoLoCOV-CVD) Study | 2024-03-08 | https://doi.org/10.3390/jcm13061559 | Agata Bielecka-Dabrowa | https://www.mdpi.com/2077-0383/13/6/1559 | At both the 3-month and 1-year post-recovery marks, females consistently reported a higher frequency of LC symptoms compared to males. Moreover, after 1 year of follow-up, females exhibited a higher prevalence of LC compared to males, with rates of 14% versus 8.3%, respectively. The symptoms that significantly differed between females and males in the 12-month follow-up were hair loss, memory and concentration disturbances, and headaches. Females presented lower mean arterial pressure (MAP) and lower pulse pressure (PP) and more elevated heart rates (HRs). Males had a higher occurrence of ECG abnormalities such as QRS >= 120 ms, ST-T changes, T inversion, arrhythmia, and QRS fragmentation. | |||||||||||||||||||||
286 | COVID-19 and Mortality in the Global Surgical Population: A Systematic Review and Meta-Analysis | 2024-03-09 | https://doi.org/10.1016/j.jss.2024.01.021 | Prisca Obidike | https://www.journalofsurgicalresearch.com/article/S0022-4804(24)00042-8/abstract | Patients undergoing surgery with COVID-19 elicited a nine-fold increased risk of mortality (relative risk [RR] 8.99, 95% confidence interval [CI] 4.96-16.32) over those without COVID-19. In low-income and middle-income countries (RR: 16.04, 95% CI: 4.59-56.12), the mortality risk was twice as high compared to high-income countries (RR: 7.50, 95% CI: 4.30-13.09). | |||||||||||||||||||||
287 | Risks of incident major osteoporotic fractures following SARS-CoV-2 infection among older individuals: a population-based cohort study in Hong Kong | 2024-03-09 | https://doi.org/10.1093/jbmr/zjae041 | David Tak Wai Lui | https://academic.oup.com/jbmr/advance-article/doi/10.1093/jbmr/zjae041/7624987?login=false | Upon median follow-up of 11 months, COVID-19 patients had higher risks of major osteoporotic fractures (5.08 vs 3.95 per 1000 persons; HR 1.22 95%CI [1.15–1.31]), hip fractures (2.71 vs 1.94; 1.33 [1.22–1.46]), clinical vertebral fractures (0.42 vs 0.31; 1.29 [1.03–1.62]) and falls (13.83 vs 10.36; 1.28 [1.23–1.33]). In acute (within 30 days) and post-acute phases (beyond 30 days) following SARS-CoV-2 infection, we consistently observed a significant increase in fractures and falls risks. | |||||||||||||||||||||
288 | Transmission electron microscopy reveals the presence of SARS-CoV-2 in human spermatozoa associated with an ETosis-like response | 2024-03-12 | https://doi.org/10.1111/andr.13612 | Jorge Hallak | https://onlinelibrary.wiley.com/doi/abs/10.1111/andr.13612 | In moderate-to-severe clinical scenarios, we identified the severe acute syndrome coronavirus 2 inside spermatozoa in nine of 13 patients up to 90 days after discharge from the hospital. | |||||||||||||||||||||
289 | The association between prolonged SARS-CoV-2 symptoms and work outcomes | 2024-03-13 | https://doi.org/10.1101/2024.03.10.24304054 | Arjun Venkatesh | https://www.medrxiv.org/content/10.1101/2024.03.10.24304054v1 | At three months post-infection, 40.8% of participants reported at least one SARS-CoV-2 symptom and 9.6% of participants reported five or more SARS-CoV-2 symptoms. When asked about missed work due to their SARS-CoV-2 infection at three months, 7.1% of participants reported missing ≥10 workdays and 13.9% of participants reported not returning to work since their infection. At three months, participants with ≥5 symptoms had a higher adjusted odds ratio (aOR) of missing ≥10 workdays (2.96, 95% CI 1.81-4.83) and not returning to work (2.44, 95% CI 1.58-3.76) compared to those with no symptoms. | |||||||||||||||||||||
290 | Short- and Long-Term Chest-CT Findings after Recovery from COVID-19: A Systematic Review and Meta-Analysis | 2024-03-14 | https://doi.org/10.3390/diagnostics14060621 | Mustufa Babar | https://www.mdpi.com/2075-4418/14/6/621 | In conclusion, significant CT abnormalities remained up to 2 years post-COVID-19, especially in patients with severe disease. Long-lasting pulmonary abnormalities post-SARS-CoV-2 infection signal a future public health concern. | |||||||||||||||||||||
291 | Persistent ENT Manifestations in Individuals who Recovered from COVID-19: A Systematic Review | 2024-03-15 | DOI: 10.1055/s-0043-1777805 | Akriti Sharma | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1777805#info | Otorhinolaryngological complications such as tinnitus, SNHL, vertigo, nasal congestion, sinonasal discomfort, hyposmia/anosmia, dysgeusia, sore throat, dry cough, dyspnea, dysphagia, and hoarseness of voice have been widely reported among in long-COVID patients. | |||||||||||||||||||||
292 | Impact of post-COVID-19 condition on health status and activities of daily living: the PRIME post-COVID study | 2024-03-18 | https://doi.org/10.1136/thorax-2023-220504 | Maarten Van Herck | https://thorax.bmj.com/content/early/2024/03/18/thorax-2023-220504 | Individuals with PCC (post-COVID-19 condition) have substantially worse health and more ADL (activities of daily living) impairment than negative controls, irrespective of the case definition. 39.4% of positives had PCC by the WHO case definition (EQVAS: 71±20; EQ5D index: 0.800±0.191; ADL impairment: 30 (10–70)%) and perceived worse health and more ADL impairment than negatives. | |||||||||||||||||||||
293 | Improved pulmonary function and exercise tolerance despite persistent pulmonary fibrosis over 1 year after severe COVID-19 infection | 2024-03-21 | https://doi.org/10.1136/thorax-2023-220370 | Claire F McGroder | https://thorax.bmj.com/content/early/2024/03/21/thorax-2023-220370 | 64% have fibrotic patterns >1 year later. Despite a high prevalence of fibrotic patterns (64%), pulmonary function, grip strength, 6 min walk distance and frailty normalised. Overall, dyspnoea, cough and exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies. | |||||||||||||||||||||
294 | Risk of kidney and liver diseases after COVID-19 infection: A systematic review and meta-analysis | 2024-03-21 | https://doi.org/10.1002/rmv.2523 | Bei Pan | https://onlinelibrary.wiley.com/doi/10.1002/rmv.2523 | Fifteen cohort studies with more than 32 million participants were included in the systematic review COVID-19 was associated with a 35% greater risk of kidney diseases (10 more per 1000 persons; low certainty evidence) and 54% greater risk of liver disease (3 more per 1000 persons; low certainty evidence). The findings provide further evidence for the association between COVID-19 and incident kidney and liver conditions. The absolute magnitude of the effect of COVID-19 on kidney and liver outcomes was, however, relatively small. | |||||||||||||||||||||
295 | Increasing Prevalence of Voice Disorders in the USA: Updates in the COVID Era | 2024-03-25 | https://doi.org/10.1002/lary.31409 | Matthew R. Naunheim | https://onlinelibrary.wiley.com/doi/10.1002/lary.31409 | The 17.6 million Americans with long COVID symptoms were more likely to have voice complaints than those without (21.1% vs. 11.6%,95%CI[18.9–23.5%] and [11.1–12.1%], respectively). Voice problems affect approximately 1 in 8 adults in the U.S. annually, demonstrating an alarming increased prevalence since 2012 using the same survey methodology. Further study is required regarding the impact of COVID and changes in voice use patterns on voice disorders. | |||||||||||||||||||||
296 | Pulmonary diffusing capacity for carbon monoxide and nitric oxide after COVID-19: A prospective cohort study (the SECURe study) | 2024-03-26 | https://doi.org/10.1113/EP091757 | Anna Agnes Lytzen | https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP091757 | In patients who have had COVID-19, the changes in pulmonary diffusing capacity for carbon monoxide and nitric oxide, the alveolar–capillary membrane diffusing capacity and pulmonary capillary blood volume observed at approximately 6 months follow-up largely persist 1 year after the acute disease, despite a marked improvement in physical performance. | |||||||||||||||||||||
297 | COVID-19’s Effect on Pre-existing Hearing Loss | 2024-03-27 | Jonathan Mikhail | https://hearingreview.com/hearing-loss/covid-19s-effect-on-pre-existing-hearing-loss | Our study found that COVID-19 was associated with increased (exacerbated) hearing loss in individuals with hearing loss existing before contracting the virus. Although word recognition scores (WRS) did not show a significant change if compensatory volume was given to patients who had lost more hearing, their speech reception thresholds (SRTs) regressed. | ||||||||||||||||||||||
298 | Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity | 2024-03-28 | https://doi.org/10.1016/j.clinsp.2024.100344 | Jamila Al-Zadjali | https://www.sciencedirect.com/science/article/pii/S1807593224000218?via%3Dihub | Findings indicated significant metabolic shifts in severe Long-COVID-19 cases, mainly a marked drop in HDL-C levels and a doubled increase in ferritin levels and insulin resistance compared to the mild cases and controls. These metabolic shifts, along with other changes in metabolic risk factors, persist for several months post-COVID-19 in severe cases, differentiating them from mild cases and controls. This persistence suggests a potential role for these metabolic changes in exacerbating the severity and progression of Long-COVID-19. | |||||||||||||||||||||
299 | Long-term impacts of COVID-19 on severe exacerbation and mortality in adult asthma: A nationwide population-based cohort study | 2024-03-29 | https://doi.org/10.1016/j.jaip.2024.03.035 | Hyun Lee | https://pubmed.ncbi.nlm.nih.gov/38556045/ | During a median follow-up of 87 (range, 15-448) days, the incidence rate of severe exacerbation in the COVID-19 cohort and matched cohort was 187.3 and 119.3 per 10,000 person-years, respectively. The COVID-19 cohort had a higher risk of severe exacerbation compared to the matched cohort (hazard ratio=1.57; 95% confidence interval [CI]=1.06-2.32). During a median follow-up of 360 (range, 15-721) days, the incidence rate of death in the COVID-19 and matched cohort was 128.3 and 73.5 per 10,000 person-years, respectively. The COVID-19 coh | |||||||||||||||||||||
300 | One-year follow-up of COVID-19 recoverees with impaired pulmonary function: A prospective cohort study | 2024-04-01 | https://doi.org/10.1016/j.idnow.2024.104890 | Nitzan Karny Epstein | https://www.sciencedirect.com/science/article/pii/S2666991924000459 | At follow-up, mean DLCO (diffusion capacity for carbon monoxide) increased from 68.0 % to 72.6 % (p = 0.002); while 33 % of the cohort experienced a clinically significant rise (>10 points) in DLCO, only 29 % normalized their values. While DLCO change did not correlate with symptoms, lack of improvement was more prevalent among individuals with obesity. Regardless of COVID-19 severity, a substantial proportion continued to exhibit DLCO impairment at 1-year. | |||||||||||||||||||||
301 | Risk of herpes zoster in adults with SARS-CoV-2 infection in Spain: a population-based, retrospective cohort study | 2024-04-02 | https://doi.org/10.1016/j.ijid.2024.107037 | Elisa Correcher-Martínez | https://www.ijidonline.com/article/S1201-9712(24)00108-5/fulltext | Individuals ≥ 18-year-old with SARS-CoV-2-confirmed infection had a 19% higher risk of developing HZ versus SARS-CoV-2-free ≥ 18-year-olds (adjusted RR = 1.19; 95% CI, 1.09–1.29); this percentage was 16% (adjusted RR = 1.16; 95% CI, 1.05–1.29) in ≥ 50-year-olds. Severe (hospitalized) cases of SARS-CoV-2 infection had a 64% (if ≥ 18 years old) or 44% (if ≥ 50 years old) higher risk of HZ versus non-hospitalized cases. | |||||||||||||||||||||
302 | Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach | 2024-04-02 | https://doi.org/10.1021/acs.jproteome.3c00706 | Sara Martínez | https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00706 | Here, a multiplatform mass spectrometry-based approach was used for metabolomic and lipidomic profiling of human plasma samples from Long COVID patients (n = 40) to reveal mitochondrial dysfunction when compared with individuals fully recovered from acute mild COVID-19. We report specific metabolites altered in Long COVID, mainly related to a decrease in the amino acid metabolism and ceramide plasma levels and an increase in the tricarboxylic acid (TCA) cycle, reinforcing the evidence of an impaired mitochondrial function. | |||||||||||||||||||||
303 | MENTAL HEALTH OUTCOMES IN COVID-19 SURVIVORS: ROLE OF CLINICAL PREDICTORS | 2024-04-02 | https://doi.org/10.24869/psyd.2024.379 | Matthieu Pierre | https://psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol36_no3-4/dnb_vol36_no3-4_379.pdf | The prevalence of psychopathological outcomes in COVID-19 survivors in this study was increased compared to the general population and in line with previous research. The study found a prevalence of PTSD, anxiety, and depression symptoms of 14%, 14% and 10.8% respectively three months after hospital discharge. | |||||||||||||||||||||
304 | The Aftermath of COVID-19: Exploring Long-Term Effects on the Organ Systems | 2024-04-03 | https://doi.org/10.20944/preprints202404.0312.v1 | Maryam Golzardi | https://www.preprints.org/manuscript/202404.0312/v1 | Long COVID poses a complicated set of health difficulties, mostly impacting the neurological, cardiovascular, pulmonary, endocrine, digestive, and dermatological systems, with significant consequences for public health. The persistence of neuropsychiatric symptoms, cardiovascular complications, respiratory issues, endocrine disruptions, gastrointestinal disturbances, and skin abnormalities emphasizes the multifaceted nature of Long COVID and the urgent need for additional research and holistic approaches to its management and mitigation. | |||||||||||||||||||||
305 | Two- and 3-year outcomes in convalescent individuals with COVID-19: A prospective cohort study | 2024-04-04 | https://doi.org/10.1002/jmv.29566 | Huqin Yang | https://onlinelibrary.wiley.com/doi/10.1002/jmv.29566 | Our study indicated that symptoms and pulmonary abnormalities persisted in COVID-19 survivors at 3 years. At 3 years, 39.80% of the participants had at least one symptom; most frequently, fatigue, difficulty sleeping, joint pain, shortness of breath, muscle aches, and cough. The participants experienced different degrees of pulmonary function impairment, with decreased carbon monoxide diffusion capacity being the main feature; results remained relatively stable over the 2–3 years. | |||||||||||||||||||||
306 | Clinical presentation of post-COVID pain and its impact on quality of life in long COVID patients: a cross-sectional household survey of SARS-CoV-2 cases in Bangladesh | 2024-04-04 | https://doi.org/10.1186/s12879-024-09267-3 | Md. Feroz Kabir | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09267-3 | Three out of ten people with long COVID experience painful symptoms, which can significantly reduce their quality of life. People with LCS as pain, multiple LCS, and longer duration of LCS had significantly lower quality of life across all domains of the WHOQOL-BREF (P < 0.001) compared to asymptomatic cases. | |||||||||||||||||||||
307 | Long-Term Symptoms Associated With SARS-CoV-2 Infection Among Blood Donors | 2024-04-08 | https://doi.org/10.1001/jamanetworkopen.2024.5611 | Melisa M. Shah | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2817293 | In this cross-sectional study of 238 828 survey participants, 43.3% of those with a history of SARS-CoV-2 infection reported new long-term symptoms compared with 22.1% without a history of infection. After controlling for age, sex, race and ethnicity, and number of underlying conditions, those with a history of SARS-CoV-2 infection had an increased odds of new long-term symptoms compared with those without (adjusted odds ratio [AOR], 2.55; 95% CI, 2.51-2.61). | |||||||||||||||||||||
308 | Plasma-based antigen persistence in the post-acute phase of COVID-19 | 2024-04-08 | https://doi.org/10.1016/S1473-3099(24)00211-1 | Michael J Peluso | https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00211-1/fulltext | Our data provide strong evidence that SARS-CoV-2, in some form or location, persists for up to 14 months following acute SARS-CoV-2 infection. These findings suggest the influence of the acute phase of infection in establishing a persistent SARS-CoV-2 reservoir. | |||||||||||||||||||||
309 | SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure | 2024-04-10 | https://doi.org/10.1371/journal.ppat.1012156 | Monu Monu | https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012156 | The cells lining the BRB (blood-retinal barrier) showed induced expression of viral entry receptors and increased susceptibility towards SARS-CoV-2-induced cell death. Furthermore, hyperglycemic conditions enhanced the viral entry receptor expression, infectivity, and susceptibility of SARS-CoV-2-induced cell death in the BRB cells, confirming the reported heightened pathological manifestations in comorbid populations. Collectively, our study provides the first evidence of SARS-CoV-2 ocular tropism via cells lining the BRB and that the virus can infect the retina via systemic permeation and induce retinal inflammation. | |||||||||||||||||||||
310 | One-Year Recovery Among Survivors of Prolonged Severe COVID-19: A National Multicenter Cohort | 2024-04-10 | https://doi.org/10.1097/CCM.0000000000006258 | Makam, Anil N. | https://journals.lww.com/ccmjournal/abstract/9900/one_year_recovery_among_survivors_of_prolonged.325.aspx | Approximately two-thirds (64%) had a persistent impairment, including physical (57%), respiratory (49%; 19% on supplemental oxygen), psychiatric (24%), and cognitive impairments (15%). Nearly half (47%) had two or more impairment types. While considered life-altering with 78.7% not returning to their usual health, participants expressed gratitude for recovering; 99% returned home and 60% of previously employed individuals returned to work. | |||||||||||||||||||||
311 | Risk factors for COVID-19 associated pulmonary aspergillosis and outcomes in patients with acute respiratory failure in a respiratory sub-intensive care unit | 2024-04-11 | https://doi.org/10.1186/s12879-024-09283-3 | Alessandra Iacovelli | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09283-3 | CAPA (COVID-19-associated pulmonary aspergillosis) is a life-threatening condition with high mortality rates. Mortality rate was higher in CAPA cohort (61.8% vs 22.7%, p < 0.0001). CAPA resulted an independent risk factor for in-hospital mortality [OR 2.92 (95%CI 1.47–5.89), p = 0.0024]. Among CAPA patients, age > 65 years resulted a predictor of mortality [OR 5.09 (95% CI 1.20–26.92), p = 0.035]. | |||||||||||||||||||||
312 | Organ-Dysfunction Markers in Mild-to-Moderate COVID-19 Convalescents | 2024-04-12 | https://doi.org/10.3390/jcm13082241 | Aleksandra Wiśniewska | https://www.mdpi.com/2077-0383/13/8/2241 | Mild-to-moderate COVID-19 convalescents are at a low risk of developing lung fibrosis or chronic kidney disease. However, they present some markers of persistent immunological exhaustion at least 6 months after disease recovery. We found significant differences in Lp-PLA2, S100, and NCAM-1 between convalescents and never-infected subjects. Lp-PLA2 and NCAM-1 were lower, and S100 higher, in convalescents than in the control group. | |||||||||||||||||||||
313 | Insights into early recovery from Long COVID—results from the German DigiHero Cohort | 2024-04-13 | https://doi.org/10.1038/s41598-024-59122-3 | Sophie Diexer | https://www.nature.com/articles/s41598-024-59122-3 | 5098 participants reported symptoms at 4–12 weeks after their SARS-CoV-2 infection, of which 2441 (48%) reported no symptoms after 12 weeks. We identified four symptom groups that can be described as diverse symptoms including typical Long COVID symptoms, symptoms of an acute infection, gastrointestinal symptoms, and cardiorespiratory symptoms. The first and fourth group were both negatively associated with early recovery from Long COVID while the second group was positively associated with early recovery. | |||||||||||||||||||||
314 | Renal implications of coronavirus disease 2019: insights into viral tropism and clinical outcomes | 2024-04-13 | https://doi.org/10.1016/j.mib.2024.102475 | Valentin A Bärreiter | https://www.sciencedirect.com/science/article/pii/S1369527424000511 | There is a profound impact of SARS-CoV-2 on renal health, revealing a complex interplay between viral tropism, comorbidities, and the subsequent manifestation of kidney damage. The renal manifestations of coronavirus infection, ranging from proteinuria and hematuria to collapsing glomerulopathy and acute renal failure, underscore the severity and diversity of kidney-related complications in COVID-19 patients | |||||||||||||||||||||
315 | Are Kidneys Affected by SARS-CoV-2 Infection? An Updated Review on COVID-19-Associated AKI | 2024-04-16 | https://doi.org/10.3390/pathogens13040325 | Fabrizio Fabrizi | https://www.mdpi.com/2076-0817/13/4/325 | AKI (acute Kidney Injury) is a common complication of hospitalized SARS-CoV-2-infected patients. We retrieved 24 reports (n = 502,593 unique patients with SARS-CoV-2 infection) and found an incidence of AKI of 31.8% (range, 0.5% to 56.9%). The unadjusted relative risk (aRR) of AKI was greater in SARS-CoV-2 patients who underwent ICU admission vs. those who did not; the pooled estimate of AKI risk was 2.64 (95% CI, 1.96; 3.56). | |||||||||||||||||||||
316 | Precision Phenotyping for Curating Research Cohorts of Patients with Post-Acute Sequelae of COVID-19 (PASC) as a Diagnosis of Exclusion | 2024-04-16 | https://doi.org/10.1101/2024.04.13.24305771 | Alaleh Azhir | https://www.medrxiv.org/content/10.1101/2024.04.13.24305771v2.full-text | Our estimated prevalence of PASC was 22.8 percent, which is close to the national estimates for the region. We found that having a prior PASC increases the chances of having more PASC in subsequent infections. This could be due to long-haulers’ inability to mount an appropriate, timely immune response to clear the COVID-19 infection each time, leading to greater susceptibility to developing PASC in subsequent infections. | |||||||||||||||||||||
317 | Persistent Smell Disorders After COVID-19 Infection and Their Impact on Quality of Life | 2024-04-17 | https://doi.org/10.7759%2Fcureus.58469 | Yahya A Fageeh | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100972/ | A total of 52.7% of the respondents reported a loss of smell after recovering from COVID-19, and 14.9% reported a persistent loss of their sense of smell. The most common types of smell disorders experienced were hyposmia, anosmia, and parosmia. The study revealed emotional distress, changes in eating habits, and social impact among participants with smell disorders. | |||||||||||||||||||||
318 | Cytokine profiles of mild-to-moderate SARS-CoV-2 infected and recovered pre-vaccinated individuals residing in Indonesia | 2024-04-18 | https://doi.org/10.7717/peerj.17257 | Ni Luh Ayu Megasari | https://peerj.com/articles/17257/ | IL-8, CCL-2, and CCL-4 were significantly elevated in pre-vaccinated Indonesian individuals with mild-to-moderate SARS-CoV-2 infection and those who recovered. The cytokine profiles described in this study might indicate inflammatory responses not only among SARS-CoV-2 infected, but also recovered individuals. The levels of IL-8 along with CCL-2 and CCL-4, were significantly higher (p ≤ 0.01) in hospitalized patients with mild-to-moderate SARS-CoV-2 infection and recovered individuals compared to healthy controls. | |||||||||||||||||||||
319 | Prevalence and clinical presentations of post-COVID-19 conditions in Nepal | 2024-04-19 | https://doi.org/10.1101/2024.04.17.24305977 | Lila Bahadur Basnet | https://www.medrxiv.org/content/10.1101/2024.04.17.24305977v1 | The prevalence of post-COVID-19 symptoms among the study population is found to be high. Among 6151 respondents (62.25% males), more than half (59.03%) had at least one symptom after recovery from acute COVID-19. The most common symptoms were anxiety (28.5%), loss of appetite (25.3%), shortness of breath (24.13%), fatigue (23.24%), depressed mood (18.79%), muscle ache (17.59%), chest pain (16.81%), headache (14.78%), and palpitation (13%). | |||||||||||||||||||||
320 | The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China | 2024-04-22 | https://doi.org/10.1016/S1473-3099(24)00171-3 | Wenting Zuo | https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00171-3/fulltext | Our findings suggest that residual SARS-CoV-2 can persist in patients who have recovered from mild COVID-19 and that there is a significant association between viral persistence and long COVID symptoms. Viral RNA was detected in 16 (30%) of 53 solid tissue samples collected at 1 month, 38 (27%) of 141 collected at 2 months, and seven (11%) of 66 collected at 4 months. Viral RNA was distributed across ten different types of solid tissues. etection of viral RNA in recovered patients was significantly associated with the development of long COVID symptoms (odds ratio 5·17, 95% CI 2·64–10·13, p<0·0001). | |||||||||||||||||||||
321 | Long-term outcome of pulmonary involvement in patients with coronavirus disease 2019: The role of high-resolution computed tomography and functional status – A prospective single-center observational study | 2024-04-25 | https://doi.org/10.4103%2Fatm.atm_191_23 | https://pubmed.ncbi.nlm.nih.gov/38766376 | Sadia Imtiaz | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100471/ | Hospitalized COVID-19 survivors are at increased risk of developing long-term pulmonary complications, including lung fibrosis. Overall, 22.6% (24) of patients had residual radiological abnormalities. Overt fibrosis was observed in 12.2% of patients. Impaired diffusion capacity (median diffusion capacity for carbon monoxide: 60%, interquartile range [IQR]: 51–80), restrictive lung defect (mean total lung capacity: 73.4% ± 18% predicted), and reduced exercise tolerance (median 6-min walk distance: 360 m, IQR: 210–400) were the predominant features at baseline. With the exception of exercise tolerance, a statistically significant improvement was observed in lung function parameters at the extended follow-up (2 years). | ||||||||||||||||||||
322 | Long-Term Impairment of Working Ability in Subjects under 60 Years of Age Hospitalised for COVID-19 at 2 Years of Follow-Up: A Cross-Sectional Study | 2024-04-26 | https://doi.org/10.3390/v16050688 | Luisa Frallonardo | https://www.mdpi.com/1999-4915/16/5/688 | This cross-sectional study involved 322 subjects hospitalised for COVID-19 from 1 March 2020 to 31 December 2022. Among the 322 subjects who were interviewed, 184 reported comparable working ability (57.1%) and 134 reported impaired working ability (41.6%) compared to the pre-COVID-19 period. | |||||||||||||||||||||
323 | Factors affecting the work ability of nursing personnel with post-COVID infection | 2024-04-27 | https://doi.org/10.1038/s41598-024-60437-4 | Warunee Tangsathajaroenporn | https://www.nature.com/articles/s41598-024-60437-4 | Post-COVID infection, especially long COVID, adversely affect nursing personnel's work ability. A significant association was found between WAI (Work Ability Index) and post-COVID infection (aOR: 3.64, 95% CI 1.59–8.30), with the short COVID group had a significantly higher WAI than the long COVID group (mean difference 2.25, 95% CI 1.44–3.05). | |||||||||||||||||||||
324 | PASC (Post Acute Sequelae of COVID-19) is associated with decreased neutralizing antibody titers in both biological sexes and increased ANG-2 and GM-CSF in females | 2024-04-29 | https://doi.org/10.1038/s41598-024-60089-4 | Ethan B. Jansen | https://www.nature.com/articles/s41598-024-60089-4 | We found PASC individuals to have significantly decreased levels of neutralizing antibodies toward both SARS-CoV-2 and the Omicron BA.1 variant. With lower levels of virus neutralizing antibodies, this data suggests that PASC individuals not only have had a suboptimal antibody response during acute SARS-CoV-2 infection but may also have increased susceptibility to subsequent infections which may exacerbate or prolong current PASC illnesses. | |||||||||||||||||||||
325 | Post-COVID-19 respiratory sequelae two years after hospitalization: an ambidirectional study | 2024-05-01 | https://doi.org/10.1016/j.lana.2024.100733 | Carlos Roberto Ribeiro Carvalho | https://www.sciencedirect.com/science/article/pii/S2667193X24000607 | Post-COVID-19 lung sequelae can persist and progress after hospital discharge, suggesting airways involvement and formation of new fibrotic-like lesions, mainly in patients who were in intensive care unit (ICU). Five (2%) patients improved compared to the 6-12-month assessment, but 20 (25%) of 80 presented worsening of lung abnormalities. | |||||||||||||||||||||
326 | Long-COVID improves in 50% of patients after a year in a Midwestern cohort | 2024-05-01 | https://doi.org/10.1101/2024.04.30.24306497 | Grant Stalker | https://www.medrxiv.org/content/10.1101/2024.04.30.24306497v1 | Overall, 51.2% respondents improved since their long-COVID began. Pulmonary symptoms were more persistent than neuromuscular symptoms (anosmia, dysgeusia, myalgias). Gender, time since acute COVID infection, and its severity didn’t affect subjective status or symptoms. | |||||||||||||||||||||
327 | Temporal trajectories of COVID-19 symptoms in adults with 22 months follow-up in a prospective cohort study in Norway | 2024-05-01 | https://doi.org/10.1101/2024.04.30.24306604 | Merete Ellingjord-Dale | https://www.medrxiv.org/content/10.1101/2024.04.30.24306604v1 | A positive SARS-CoV-2 test was associated with new onset memory- and concentration problems, anosmia and dysgeusia, dyspnoea and fatigue as well as self-assessed worsening of overall health, which persisted for the length of the follow-up of 22 months, even when correcting for symptoms before COVID-19 and compared to symptoms in negative controls. | |||||||||||||||||||||
328 | Assessment of the liver with two-dimensional shear wave elastography following COVID-19 infection: A pilot study | 2024-05-06 | https://doi.org/10.1002/ajum.12390 | Joyce Yea See Lau | https://onlinelibrary.wiley.com/doi/10.1002/ajum.12390 | A statistically significant increase in liver stiffness value was observed in the post-COVID-19 infection group compared to the group who had never been infected. The mean liver stiffness of 5.26 ± 1.63 kPa in the COVID-19 group exhibited a statistically significant increase compared to the control group. | |||||||||||||||||||||
329 | Persistent Activation of Chronic Inflammatory Pathways in Long Covid | 2024-05-13 | https://doi.org/10.1101/2024.05.11.593709 | Malika Aid | https://www.biorxiv.org/content/10.1101/2024.05.11.593709v1 | Long Covid was characterized by persistent inflammatory pathways compared with convalescent controls and uninfected controls, including upregulation of IL-6 and JAK-STAT pathways as well as activation of coagulation, complement, metabolism, and T cell exhaustion pathways. Moreover, robust activation of these pathways during acute COVID-19 infection correlated with the subsequent development of Long Covid. | |||||||||||||||||||||
330 | Potential Diaphragm Muscle Weakness-related Dyspnea Persists Two Years after COVID-19 and Could Be Improved by Inspiratory Muscle Training: Results of an Observational and an Interventional Trial | 2024-05-19 | https://doi.org/10.1164/rccm.202309-1572oc | Jens Spiesshoefer | https://pubmed.ncbi.nlm.nih.gov/38763165/ | At median 31 [IQR 23-32] months after hospitalization, 21/30 individuals reported relevant persistent exertional dyspnea. Diaphragm muscle weakness on exertion and reduced diaphragm cortical activation were potentially related to exertional dyspnea. | |||||||||||||||||||||
331 | Investigating the effects of the Omicron variant of COVID-19 on sperm parameters and serum levels of male sexual hormones: Prospective observational study | 2024-05-19 | https://doi.org/10.1016/j.nmni.2024.101432 | Yaser Mohammadi | https://www.sciencedirect.com/science/article/pii/S2052297524002166?via%3Dihub | Serum levels of sex hormones (testosterone, FSH, and prolactin) in the COVID-19 group were significantly decreased compared to the healthy group. Microscopic examination of semen revealed significant differences in vitality, progressive, and motile parameters among the three groups, with a decrease observed in the COVID-19 group. | |||||||||||||||||||||
332 | Prevalence and Risk Factors of Multi-type Post-COVID Pain in a Cohort of Previously Hospitalized COVID-19 Survivors: A Danish Cross-Sectional Survey | 2024-05-23 | https://doi.org/10.1016/j.jpain.2024.104579 | Brian Duborg Ebbesen | https://www.sciencedirect.com/science/article/abs/pii/S1526590024005145 | Multi-type pain as a de novo post-COVID symptom was present in 18.0% of previously hospitalized COVID-19 survivors more than one year after hospital discharge and as such can be considered as adding to the global burden of chronic pain. De novo multi-type post-COVID pain persists for at least 21 months on average. | |||||||||||||||||||||
333 | Long-term Health-related Quality of Life in Working-age COVID-19 Survivors: A Cross-sectional Study | 2024-05-23 | https://doi.org/10.1016/j.amjmed.2024.05.016 | Hiten Naik MD | https://www.sciencedirect.com/science/article/pii/S0002934324003383 | Of the 1,135 analyzed participants, 19.2% had current PCC, and 27.6% had recovered PCC. Compared to those without a history of PCC, participants with current PCC were more likely to report problems with mobility (adjusted odds ratio (aOR) 6.00), self-care (aOR 5.96), usual activities (aOR 8.00), pain/discomfort (aOR 4.28), and anxiety/depression (aOR 3.45). | |||||||||||||||||||||
334 | Patient-reported experiences of persistent post-Covid-19 conditions after hospital discharge during the pandemic’s second and third waves in Switzerland: a post-hospitalization survey | 2024-05-23 | https://doi.org/10.2196/47465 | Nadine Tacchini-Jacquier | https://preprints.jmir.org/preprint/47465/accepted | The majority of SARS-CoV-2-infected inpatients presented with PCCs at four months after discharge, with complex clinical pictures. Only one-third of them were symptom-free during that time.Three-quarters (76.4%) of the respondents affected by COVID-19 reported memory loss and concentration disorders (Q3PC). | |||||||||||||||||||||
335 | Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis | 2024-05-23 | https://doi.org/10.1093/jpids/piae052 | Camila Aparicio | https://academic.oup.com/jpids/advance-article-abstract/doi/10.1093/jpids/piae052/7680285 | In previously healthy children, the absolute risk of critical disease from COVID-19 was 4% (95% CI, 1%–10%). Compared with no comorbidities, the pooled OR for critical disease was 3.95 (95% CI, 2.78–5.63) for the presence of one comorbidity and 9.51 (95% CI, 5.62–16.06) for ≥2 comorbidities. | |||||||||||||||||||||
336 | Acute and post-acute respiratory complications of SARS-CoV-2 infection: population-based cohort study in South Korea and Japan | 2024-05-27 | https://doi.org/10.1038/s41467-024-48825-w | Yujin Choi | https://www.nature.com/articles/s41467-024-48825-w | The risk of acute respiratory complications or post-acute respiratory sequelae is significantly increased in people with SARS-CoV-2 infection compared to the general population (acute respiratory complications: HR, 8.06 [95% CI, 6.92-9.38]; post-acute respiratory sequelae: 1.68 [1.62-1.75]), and the risk increased with increasing COVID-19 severity. Furthermore, while the excess post-acute risk diminished with time following SARS-CoV-2 infection, it persisted beyond 6 months post-infection. | |||||||||||||||||||||
337 | Lung function and quality of life one year after severe COVID-19 in Brazil | 2024-05-27 | https://doi.org/10.36416/1806-3756/e20230261 | Tarciane Aline Prata | https://pubmed.ncbi.nlm.nih.gov/38808823/ | After one year, survivors of severe COVID-19 in a middle-income country still present with high symptom burden, restrictive ventilatory changes, and loss of quality of life. At 12 months of follow-up, 43% of patients presented with dyspnea, 27% of whom had a restrictive ventilatory disorder and 18% of whom presented with impaired DLCO (Diffusing capacity of the lungs for carbon monoxide). | |||||||||||||||||||||
338 | Deep learning reveals lung shape differences on baseline chest CT between mild and severe COVID-19: A multi-site retrospective study | 2024-05-29 | https://doi.org/10.1016/j.compbiomed.2024.108643 | Amogh Hiremath | https://www.sciencedirect.com/science/article/pii/S0010482524007285 | In conclusion, we demonstrated that there are significant differences in lung shape and morphology between COVID-19 patients with mild and severe disease.Additionally, differences were seen on basal surfaces of the lung when compared between healthy and severe COVID-19 patients. | |||||||||||||||||||||
339 | Comparison of morbidity and absenteeism due to COVID-19 and seasonal influenza in a large cohort of healthcare personnel in the 2022-2023 season | 2024-05-29 | https://doi.org/10.1016/j.ajic.2024.05.015 | Helena C. Maltezou | https://www.sciencedirect.com/science/article/abs/pii/S0196655324005297 | We followed 5752 hospital-based HCP in Greece from November 14, 2022 through May 28, 2023. The mean duration of absence per COVID-19 case was 5.8 days compared with a mean of absence of 3.6 days per influenza case (p-value <0.001). Overall, COVID-19 accounted for 4245 days missed during the study period compared with 333 days missed due to influenza. | |||||||||||||||||||||
340 | Three-year outcomes of post-acute sequelae of COVID-19 | 2024-05-30 | https://doi.org/10.1038/s41591-024-02987-8 | Miao Cai | https://www.nature.com/articles/s41591-024-02987-8 | Among non-hospitalized individuals, the increased risk of death was no longer present after the first year of infection, and risk of incident PASC declined over the 3 years but still contributed 9.6 disability-adjusted life years (DALYs) per 1,000 persons in the third year. Among hospitalized individuals, risk of death declined but remained significantly elevated in the third year after infection (incidence rate ratio: 1.29). Risk of incident PASC declined over the 3 years, but substantial residual risk remained in the third year, leading to 90.0 DALYs per 1,000 persons. Our findings show reduction of risks over time, but the burden of mortality and health loss remains in the third year among hospitalized individuals. | |||||||||||||||||||||
341 | Comparing risk of post infection erectile dysfunction following SARS Coronavirus 2 stratified by acute and long COVID, hospitalization status, and vasopressor administration: a U.S. large claims database analysis | 2024-05-31 | https://doi.org/10.1038/s41443-024-00913-7 | Aurora J. Grutman | https://www.nature.com/articles/s41443-024-00913-7 | Men with long COVID were more likely to develop ED or be prescribed PDE5i (3.63%) when compared to men with only acute COVID infections (2.61%) [RR 1.39; 95% CI 1.04, 1.87]. | |||||||||||||||||||||
342 | Specific sequelae symptoms of COVID-19 of Omicron variant in comparison with non-COVID-19 patients: a retrospective cohort study in Japan | 2024-05-31 | https://doi.org/10.21037/jtd-23-1672 | Takahiro Omori | https://jtd.amegroups.org/article/view/86532/html | We found that patients with SARS-CoV-2 infection were more likely to have a loss of taste or smell [odds ratio (OR) 4.55, 95% confidence interval (CI): 1.93, 10.71], hair loss (OR 3.19, 95% CI: 1.67, 6.09), neurocognitive symptoms (OR 1.95, 95% CI: 1.43, 2.65), and respiratory symptoms (OR 1.23, 95% CI: 1.03, 1.47) than never-infected patients. | |||||||||||||||||||||
343 | Prolonged loss of intercostal muscle mass and its predictors in COVID-19 patients: A retrospective study from tertiary hospital | 2024-05-31 | https://doi.org/10.1097/md.0000000000038284 | Koo, Byeong Ju | https://journals.lww.com/md-journal/fulltext/2024/05310/prolonged_loss_of_intercostal_muscle_mass_and_its.55.aspx | Among the 3 chest wall muscles, the loss of the intercostal muscle was the most severe, whereas the loss of T12 skeletal muscle was the least in the CT follow-up. In addition, the wasting of the intercostal muscle mass worsened, pectoralis muscle wasting persisted without additional deterioration, and T12 skeletal muscle mass minimally recovered during follow-up periods exceeding 3 months. The intercostal muscle suffered the most severe damage during the follow-up period, and this muscle wasting worsened after 3 months. | |||||||||||||||||||||
344 | Investigating the fluctuating nature of post-COVID pain symptoms in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP multicenter study | 2024-06-01 | https://doi.org/10.1097/PR9.0000000000001153 | Fernández-de-las-Peñas, César | https://journals.lww.com/painrpts/fulltext/2024/06000/investigating_the_fluctuating_nature_of_post_covid.10.aspx | Up to 28% of hospitalized COVID-19 survivors report post-COVID pain after in average 1.5 years. The prevalence of myalgia as COVID-19–associated symptom was 29.82% (n = 389) at hospitalization (T0). The prevalence of post-COVID pain was 41.07% (n = 520) at T1 (8.4 months), 34.29% (n = 434) at T2 (13.2 months), and 28.47% (n = 360) at T3 (18.3 months). | |||||||||||||||||||||
345 | Persistence of COVID-19 Symptoms and Quality of Life at Three and Twelve Months after Hospital Discharge | 2024-06-05 | https://doi.org/10.3390/medicina60060944 | Lizeth Guadalupe Gutiérrez-Canales | https://www.mdpi.com/1648-9144/60/6/944 | A total of 54 (79.4%) patients reported at least one persistent symptom at three months vs. 52 (76.4%) at twelve months (p = 0.804). Some persistent symptoms (myalgia, alopecia, and cough) decreased significantly at twelve months (50% vs. 30.9%, 29.4% vs. 13.2%, and 23.5% vs. 7.4%; respectively, p = 0.007); in contrast, other persistent symptoms (sleep–wake and memory disorders) were more frequent (5.9% vs. 32.4% and 4.4% vs. 20.6%; respectively, p = ≤0.001). | |||||||||||||||||||||
346 | Clinical and Functional Assessment of SARS-CoV-2 Sequelae Among Young Marines | 2024-06-06 | https://dx.doi.org/10.2139/ssrn.4854879 | Chad K. Porter | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4854879 | A total of 197/798 (24.7%) study participants developed PASC. Among these, the most prevalent symptoms were loss of taste and/or smell (n=82; 41.6%), shortness of breath (n=74; 37.6%), and cough (n=45; 22.8%). Those with PASC had higher rates and severity of somatic (p<0.001), general depressive (p<0.001), and anxiety (p=0.005) symptoms. Compared to a historic cohort of Marines, participants with PASC scored worse on their physical fitness assessments due to slower run times (p=0.002). Those with PASC continued to have decreased physical performance one year after completing initial training. | |||||||||||||||||||||
347 | Long-Term Patient Symptoms and Quality of Life in Adults After COVID-19: A Real Life Study | 2024-06-11 | https://doi.org/10.1016/j.opresp.2024.100336 | Oscar Perez | https://www.sciencedirect.com/science/article/pii/S2659663624000390 | 16.57% (n = 115/694) reported NFFR (Not Feeling Fully Recovered). Most prevalent symptoms were in order of frequency: Fatigue (54.8%); Loss of smell (40.9%); Problems speaking or communicating (29.6%); Loss of taste (28.7%); Confusion/lack of concentration (27.8%); Persistent muscle pain (24.3%) and Shortness of breath/breathlessness (23.5%). Lastly, they scored on average 9.63 points less in Euroquol (a large decrease in quality of life). | |||||||||||||||||||||
348 | The existence of Adrenal Insufficiency in Patients with COVID-19 Pneumonia | 2024-06-12 | https://doi.org/10.3389/fendo.2024.1337652 | Thachanun Porntharukchareon | https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1337652/abstract | Our results suggest that hypocortisolism, predominantly caused by pituitary disruption, may emerge after SARS-CoV-2 infection and should be considered in patients with a history of COVID-19 pneumonia with or without clinical hypocortisolism.Eleven patients (27%) had hypocortisolism, as evidenced by peak cortisol of less than 402.81 nmol/l after low dose (1 µg) CST. | |||||||||||||||||||||
349 | Prevalence of and Risk Factors for Post–COVID-19 Condition during Omicron BA.5–Dominant Wave, Japan | 2024-06-14 | https://doi.org/10.3201/eid3007.231723 | Arisa Iba | https://wwwnc.cdc.gov/eid/article/30/7/23-1723_article | The percentage of post–COVID-19 condition for cases was 11.8%, whereas the percentage of persistent symptoms among controls was 5.5%. Among the 992 cases who had experienced any post–COVID-19 condition, 84 (8.5%) answered that the condition was a serious hindrance on their daily lives at the time of response. A total of 402 (40.5%) noted that it was no hindrance, 362 (36.5%) mild hindrance, and 144 (14.5%) moderate hindrance. | |||||||||||||||||||||
350 | Mendelian randomization supports causality between COVID-19 and glaucoma | 2024-06-14 | https://doi.org/10.1097/MD.0000000000038455 | Chen, Maolin | https://journals.lww.com/md-journal/fulltext/2024/06140/mendelian_randomization_supports_causality_between.71.aspx | This MR analysis provides preliminary evidence of a potential causal relationship between COVID-19 and glaucoma. The results showed that 2 sets of COVID-19 were significantly associated with the risk of glaucoma [ID: ebi-a-GCST011071, OR (95% CI) = 1.227; ID: ebi-a-GCST011073: OR (95% CI) = 1.164 (1.022–1.327); 2 sets of COVID-19 hospitalizations were significantly associated with the risk of glaucoma (ID: ebi-a-GCST011081, OR (95% CI) = 1.156 (1.033–1.292): ebi-a-GCST011082: OR (95% CI) = 1.097 (1.007–1.196)]. | |||||||||||||||||||||
351 | Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complication | 2024-06-14 | http://dx.doi.org/10.3748/wjg.v30.i22.2866 | Alfonso Rodriguez-Espada | https://www.wjgnet.com/1007-9327/full/v30/i22/2866.htm | Severe acute respiratory syndrome coronavirus 2 infection is linked to significant liver injury, emerging from the facilitated entry of the virus into liver cells, including cholangiocytes and endothelial cells, due to increased receptor expression. Confirmed by biopsy or autopsy, the presence of viral particles in liver tissues correlates with extensive histological damage, characterized by necrosis, steatosis, cholestasis, and inflammation. Such findings highlight the acute hepatic impact of coronavirus disease 2019 (COVID-19) and signal the risk of severe long-term complications, such as COVID-19-associated sclerosing cholangitis, emphasizing the profound and enduring effect of the virus on liver health. | |||||||||||||||||||||
352 | Physical Exercise-related Manifestations of long COVID: A Systematic Review and Meta-Analysis | 2024-06-16 | https://doi.org/10.1016/j.jesf.2024.06.001 | Chen Zheng | https://www.sciencedirect.com/science/article/pii/S1728869X24000431 | The findings suggest an underestimation of the manifestations of PASC. COVID-19 survivors also harbor physical exercise-related symptoms of PASC that can be determined by the exercise testing and are distinct from those observed at rest. The 6-minute walk test, maximal oxygen consumption (VO2max), and anaerobic threshold were impaired in COVID-19 survivors 3 months post-infection compared with non-COVID-19 controls in exercise testing. | |||||||||||||||||||||
353 | Epidemiologic Features of Recovery From SARS-CoV-2 Infection | 2024-06-17 | https://doii.org/10.1001/jamanetworkopen.2024.17440 | Elizabeth C. Oelsner | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820087 | In this cohort study of 4708 participants in a US meta-cohort, the median self-reported time to recovery from SARS-CoV-2 infection was 20 days, and an estimated 22.5% had not recovered by 90 days. Women and adults with suboptimal prepandemic health, particularly clinical cardiovascular disease, had longer times to recovery, whereas vaccination prior to infection and infection during the Omicron variant wave were associated with shorter times to recovery. | |||||||||||||||||||||
354 | Cardiovascular Magnetic Resonance Imaging in Physically Fit Young Patients Sans Comorbidities Who Recently Recovered from Coronavirus Disease 2019 (COVID-19) | 2024-06-17 | 10.26444/aaem/183591 | Agnieszka Pawlak | https://www.aaem.pl/Cardiovascular-Magnetic-Resonance-Imaging-in-Physically-Fit-Young-Patients-Sans-Comorbidities,183591,0,2.html | PCRMI (possible COVID-19 related myocardial injury) was a frequent finding in young, asymptomatic, physically-fit patients sans comorbidities relatively late after recovery from COVID-19. 19(25%) patients had possible COVID-19 related myocardial injury[PCRMI] on cardiovascular magnetic resonance [CMR] including definitive myocarditis (n=1;1.3%) and possible myocarditis (n=3;4%). Other abnormalities: mildly decreased (<50%) left ventricular(LV) ejection fraction (n=4;5%), increased LV end-diastolic volume index (n=8;11%) and LV mass index (n=9;12%). | |||||||||||||||||||||
355 | Deaths Related to Post-COVID in Italy: a National Study based on Death Cerficates | 2024-06-18 | https://doi.org/10.3389/fmed.2024.1401602 | Francesco Grippo | https://www.frontiersin.org/articles/10.3389/fmed.2024.1401602/abstract | Post-COVID conditions contributed to a substantil number of deaths in Italy. In 46.0% of post-COVID-related deaths, the underlying cause of death was COVID-19. Other frequent underlying causes were heart disease (14.3% of cases), neoplasms (9.2%), cerebrovascular diseases (6.3%) and Alzheimer's disease and other dementias (5.5%). The mortality rate related to post-COVID conditions in year 2021 was 5.1 deaths per 100 thousand. | |||||||||||||||||||||
356 | SARS-CoV-2 Infection Decreases Cardiorespiratory Fitness and Time-Trial Performance Even Two Months After Returning to Regular Training — Insights from A Longitudinal Case Series of Well-Trained Kayak Athletes | 2024-06-19 | https://doi.org/10.1016/j.jesf.2024.05.003 | Shengji Deng | https://www.sciencedirect.com/science/article/pii/S1728869X24000455 | SARS-CoV-2 infection decreased CRF (cardiorespiratory fitness) and time-trial performance even two months after return to regular training in vaccinated athletes. There were significant decreases in peak oxygen uptake (-9.7%; effect size [ES] =1.38), peak oxygen pulse (-5.7%; ES =0.96), and peak heart rate (-1.9%; ES =0.61)... Impaired tendencies were found in completion time, mean power, and mean speed (-2.4 to 1.2%; small ESs =-0.40 to 0.47) as well as significant changes in stroke rate and stroke length (-4.5 to 3.7%; ESs =-0.60 to 0.73). | |||||||||||||||||||||
357 | Function and activity capacity at 1 year after the admission to intensive care unit for COVID-19 | 2024-06-20 | https://doi.org/10.1177/02692155241262871 | Netha Hussain | https://pubmed.ncbi.nlm.nih.gov/38899867/ | 45% of the participants showed impairment in function, activity capacity or both. At 1-year following intensive care unit admission for COVID-19, impaired hand grip strength was found in 24.4% for the right hand and 23.1% for the left hand. Walking speed, functional mobility, and postural control were found to be impaired in 29.5%, 21.8%, and 5.1%, respectively. | |||||||||||||||||||||
358 | Pulmonary and renal long COVID at two-year revisit | 2024-06-20 | https://doi.org/10.1016/j.isci.2024.110344 | Jing Wang | https://www.cell.com/iscience/fulltext/S2589-0042(24)01569-4 | Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8% of patients at the 1-year and 2-year revisits, respectively, while renal long COVID was present in 15.2% and 23.9% of patients, respectively. | |||||||||||||||||||||
359 | The association between COVID-19 vaccine/infection and new-onset asthma in children - based on the global TriNetX database | 2024-06-21 | https://doi.org/10.1007/s15010-024-02329-3 | Chiao-Yu Yang | https://link.springer.com/article/10.1007/s15010-024-02329-3 | Our study found a significantly higher incidence of new-onset asthma in COVID-19 infected children compared to uninfected children, regardless of vaccination status. In Cohort 1, 4.7% of COVID-19 infected children without vaccination developed new-onset asthma, versus 2.0% in their non-COVID-19 counterparts within a year (HR = 2.26; 95% CI = 2.158–2.367). | |||||||||||||||||||||
360 | Multicenter and multimodal imaging study reveals rare fundus lesions in patients after SARS-CoV-2 infection | 2024-06-22 | https://doi.org/10.1038/s41598-024-65216-9 | Guangqi An | https://www.nature.com/articles/s41598-024-65216-9 | After SARS-CoV-2 infection, diversified fundus lesions were evident in patients with visual complaints. In this report, AMN (Acute Macular Neuroretinopathy) was the dominant manifestation, followed by Purtscher or Purtscher-like retinopathy, MEWDS (multiple evanescent white-dot syndrome), VKH-like uveitis (Vogt‒Koyanagi‒Harada), and ROCM (rhino-orbital-cerebral mucormycosis). | |||||||||||||||||||||
361 | Post-acute and Chronic Kidney Function Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Initiative | 2024-06-26 | https://doi.org/10.1101/2024.06.25.24309488 | Lu Li | https://www.medrxiv.org/content/10.1101/2024.06.25.24309488v1 | Compared with the non-infected group, patients with COVID-19 had a higher risk of adverse kidney outcomes. For patients without pre-existing CKD (chronic kidney disease), there were increased risks of CKD stage 2+ (HR 1.20) and CKD stage 3+ (HR 1.35) during the post-acute phase (28 days to 365 days) after SARS-CoV-2 infection. Within the post-acute phase of SARS-CoV-2 infection, children and adolescents with pre-existing CKD and those who experienced AKI (Acute Kidney Injury during COVID infection) were at increased risk of progression to a composite outcome defined by at least 50% decline in estimated glomerular filtration rate (eGFR), eGFR <15 mL/min/1.73m2, End Stage Kidney Disease diagnosis, dialysis, or transplant. | |||||||||||||||||||||
362 | One-year Post-Acute COVID-19 Syndrome and Mortality in South Korea: A Nationwide Matched Cohort Study Using Claims Data | 2024-06-26 | https://doi.org/10.3389/fpubh.2024.1403153 | Jung-Hyun Won | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1403153/abstract | The COVID-19 group had significantly elevated risks of coagulopathies (OR=2.70), chronic lower respiratory diseases (OR=1.96), symptoms of the circulatory and respiratory systems (OR=1.91), mood disorders (OR=1.67), cardiac diseases (OR=1.39), and symptoms of cognition, perception, emotional state, and behavior (OR=1.15). The risk of all-cause mortality post-COVID-19 is heightened for up to six months, then significantly decreases and resolves within a year. | |||||||||||||||||||||
363 | Does COVID-19 Increase the Risk of Subsequent Kidney Diseases More Than Influenza? A Retrospective Cohort Study Using Real-World Data In the United States | 2024-06-28 | https://doi.org/10.1101/2024.06.27.24309556 | Yue Zhang | https://www.medrxiv.org/content/10.1101/2024.06.27.24309556v1 | In this large real-world study, COVID-19 infections were associated with a 2.3-fold risk of developing AKI (acute kidney injury), a 1.4-fold risk of CKD (chronic kidney disease), and a 4.7-fold risk of ESRD (end-stage reneal disease) compared to influenza. | |||||||||||||||||||||
364 | Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression | 2024-06-28 | https://doi.org/10.3390/biomedicines12071443 | Sachiko T. Homma | https://www.mdpi.com/2227-9059/12/7/1443 | We conclude that a respiratory SARS-CoV-2 infection can cause myofiber atrophy and persistent energy metabolism suppression without direct viral invasion. The effects may be induced by the combined systemic interferon and TNF-α responses at the acute phase and may contribute to post-COVID-19 persistent muscle fatigue. | |||||||||||||||||||||
365 | CT-derived vertebral bone mineral density is a useful biomarker to predict COVID-19 outcome | 2024-07-01 | https://doi.org/10.1016/j.bone.2024.117095 | Shuhei Azekawa | https://www.sciencedirect.com/science/article/abs/pii/S875632822400084X | At 3 months post-infection, patients with oxygen demand during hospitalization showed markedly decreased BMD (bone mineral density) than did those on admission. BMD decreased three months after admission in COVID-19 patients with oxygen demand. | |||||||||||||||||||||
366 | Kidney Outcomes and Trajectories of Tubular Injury and Function in Critically Ill Patients With and Without COVID-19 | 2024-07-01 | https://doi.org/10.1097/CCE.0000000000001109 | Granda, Michael L. | https://journals.lww.com/ccejournal/fulltext/2024/07000/kidney_outcomes_and_trajectories_of_tubular_injury.10.aspx | Among critically ill adults, COVID-19 is associated with a more protracted course of proximal tubular dysfunction and reduced eGFR despite similar degrees of kidney injury. COVID-19 was associated with a 70% greater occurrence of MAKE (major adverse kidney events) and a 741% greater occurrence of KRT (kidney replacement therapy). | |||||||||||||||||||||
367 | High prevalence of long-term olfactory disorders in healthcare workers after COVID-19: A case-control study | 2024-07-01 | https://doi.org/10.1371/journal.pone.0306290 | Johannes Frasnelli | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0306290 | Fifteen months after contracting COVID‐19, 37% of healthcare workers demonstrated a quantitative reduction in their sense of smell, compared to only 20% of the individuals in the control group. Fifty-one percent of COVID‐19‐recovered individuals reported qualitative symptoms, compared to only 5% in the control group. In a follow-up study 2.6 years after COVID-19 diagnosis, 24% of all tested recovered individuals still experienced parosmia. | |||||||||||||||||||||
368 | Deaths related to post-COVID in Italy: a national study based on death certificates | 2024-07-02 | https://doi.org/10.3389/fmed.2024.1401602 | Francesco Grippo | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1401602/full | Post-COVID conditions contributed to a substantial number of deaths in Italy. The mortality rate related to post-COVID conditions in year 2021 was 5.1 deaths per 100 thousand inhabitants and it increased with increasing age. Men showed a higher mortality rate than women (4.3 deaths per 100 thousand in women and 6.0 deaths per 100 thousand in men). | |||||||||||||||||||||
369 | Post-COVID syndrome prevalence: a systematic review and meta-analysis | 2024-07-04 | https://doi.org/10.1186/s12889-024-19264-5 | Ruhana Sk Abd Razak | https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-19264-5 | The pooled prevalence for PCS worldwide... was 41.79%. Based on different assessment or follow-up timepoints after acute COVID-19 infection, PCS prevalence estimated at ≥ 3rd, ≥ 6th, and ≥ 12th months timepoints were each 45.06%, 41.30%, and 41.32%, respectively. | |||||||||||||||||||||
370 | Work ability and return-to-work of patients with post-COVID-19: a systematic review and meta-analysis | 2024-07-07 | https://doi.org/10.1186/s12889-024-19328-6 | Marcel Ottiger | https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-19328-6 | The RTW (return to work) for post-COVID-19 patients is complex, with approximately 60.9% of patients successfully returning to work after 12 or more weeks following SARS-CoV-2 infection. Among those who successfully returning to work, a considerable number need modifications in their work duties or hours to cope with residual impairments. Even those with mild or moderate acute SARS-CoV-2 infection required extended periods to regain their pre-illness work capacity. | |||||||||||||||||||||
371 | Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19 | 2024-07-08 | https://doi.org/10.1016/j.xcrm.2024.101642 | Shreya M. Kanth | https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00356-2 | Patients with mild to moderate disease: we observed a persistent alteration in the host defense response proteins and continued cellular repair and proteostasis in the lung as late as 9 months after symptom onset. | |||||||||||||||||||||
372 | Unveiling the detrimental vicious cycle linking skeletal muscle and COVID-19: A systematic review and meta-analysis | 2024-07-08 | https://doi.org/10.1111/jebm.12629 | Qin Wang | https://onlinelibrary.wiley.com/doi/10.1111/jebm.12629 | This study reveals a detrimental vicious circle between skeletal muscle and COVID-19. Significant skeletal muscle wasting, characterized by reduced volume and strength, was observed during COVID-19 infection and the pandemic. | |||||||||||||||||||||
373 | Deciphering Alveolo-Capillary Gas Transfer Disturbances in Patients Recovering from COVID-19 Lung Disease | 2024-07-10 | https://doi.org/10.3390/jpm14070738 | Thông Hua-Huy | https://www.mdpi.com/2075-4426/14/7/738 | Patients with mild COVID-19 had normal lung volumes and airways expiratory flows but impaired pulmonary gas exchange. These findings suggest a persistent alveolo-capillary gas transfer defect, implying not only reduced membrane conductance but also abnormal pulmonary vascular capacitance in all PACS patients, even those with a milder form of COVID-19 infection. | |||||||||||||||||||||
374 | Pre-or co-SARS-CoV-2 Infections Significantly Increase Severe Dengue Virus Disease Criteria: Implications for Clinicians | 2024-07-10 | https://doi.org/10.3390/pathogens13070573 | Moeen Hamid Bukhari | https://www.mdpi.com/2076-0817/13/7/573 | DENV-infected (dengue virus) patients with prior SARS-CoV-2 infections had significantly increased incidences of thrombocytopenia (DHF/DSS-criteria) (dengue haemorrhagic fever/shock syndrome) and/or abdominal pain and persistent vomiting and also thrombocytopenia (SD warning signs) (severe dengue). | |||||||||||||||||||||
375 | Progression From Presymptomatic to Clinical Type 1 Diabetes After COVID-19 Infection | 2024-07-15 | https://doi.org/10.1001/jama.2024.11174 | Nadine Friedl | https://jamanetwork.com/journals/jama/fullarticle/2821151?guestAccessKey=26c76ca0-e27f-4e62-8c40-fc63e2f9bba9&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=071524 | The incidence rate of type 1 diabetes during the pandemic period was 8.6 while participants had tested negative for COVID-19 and was 14.0 after COVID-19 infection. Follow-up of youth with presymptomatic type 1 diabetes demonstrated that the COVID-19 pandemic was associated with an accelerated progression to clinical disease and that this acceleration was confined to those with COVID-19. | |||||||||||||||||||||
376 | Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation | 2024-07-15 | https://doi.org/10.1097/INF.0000000000004470 | Buonsenso, Danilo | https://journals.lww.com/pidj/fulltext/9900/circulating_activated_platelets_in_children_with.947.aspx | These data demonstrate that platelets in children with Long Covid circulate in an activated state, as shown by increased expression of P-selectin, a sensitive platelet activation marker, on their membrane. Our findings, along with those on multisystem inflammatory syndrome showing microvascular damage, suggest that SARS-CoV-2 infection can determine long-term endothelial inflammation in children similarly to adults. | |||||||||||||||||||||
377 | Postacute Sequelae of SARS-CoV-2 Infection in the Pre-Delta, Delta, and Omicron Eras | 2024-07-17 | https://doi.org/10.1056/NEJMoa2403211 | Yan Xie, PhD | https://www.nejm.org/doi/full/10.1056/NEJMoa2403211 | The cumulative incidence of PASC during the first year after SARS-CoV-2 infection decreased over the course of the pandemic, but the risk of PASC remained substantial even among vaccinated persons who had SARS-CoV-2 infection in the omicron era. Decomposition analyses showed 5.23 fewer PASC events per 100 persons at 1 year during the omicron era than during the pre-delta and delta eras combined; 28.11% of the decrease was attributable to era-related effects (changes in the virus and other temporal effects), and 71.89% was attributable to vaccines. | |||||||||||||||||||||
378 | Long-term radiological and pulmonary function abnormalities at 3 years after COVID-19 hospitalisation: a longitudinal cohort study | 2024-07-18 | https://doi.org/10.1183/13993003.01612-2023 | Xiaoyu Han | https://erj.ersjournals.com/content/64/1/2301612 | Most patients exhibited improvement in radiological abnormalities and pulmonary function over time following COVID-19. However, more than a third continued to have persistent lung abnormalities at the 3-year mark, which were associated with respiratory symptoms and reduced diffusion capacity. Compared with controls, the proportions of DLCO impairment (diffusing capacity of the lung for carbon monoxide) (38% versus 17%; p<0.001) and respiratory symptoms (23% versus 2.2%; p<0.001) were significantly higher in the matched COVID-19 survivors at the 3-year follow-up. | |||||||||||||||||||||
379 | Long COVID among Brazilian Adults and Elders 12 Months after Hospital Discharge: A Population-Based Cohort Study | 2024-07-19 | https://doi.org/10.3390/healthcare12141443 | Maria Aparecida Salci | https://www.mdpi.com/2227-9032/12/14/1443 | Being an adult and having been hospitalized was associated with the development of Long COVID. The risk of developing Long COVID was twice as high for ward patients (aOR = 2.53) and three times as high for ICU patients (aOR = 3.56) when compared to non-hospitalized patients. The overall Long COVID prevalence was 64.2%. . | |||||||||||||||||||||
380 | Sleep and circadian rhythm alterations in myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID fatigue syndrome and its association with cardiovascular risk factors: A prospective cohort study | 2024-07-22 | https://doi.org/10.1080/07420528.2024.2380020 | María Fernanda Zerón-Rugerio | https://www.tandfonline.com/doi/full/10.1080/07420528.2024.2380020 | Patients showed lower activity and worse sleep quality than matched healthy controls, together with a worse lipid profile than controls, that was associated with disturbances in the circadian temperature rhythm. These findings suggest that lipid profiles in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients including a subpopulation of long-COVID patients) are linked to disrupted circadian rhythms and sleep patterns, likely due to endothelial dysfunction. | |||||||||||||||||||||
381 | Perceived fatigue and functional status after mild symptomatic and asymptomatic COVID-19 | 2024-07-22 | https://doi.org/10.1016/j.jbmt.2024.07.053 | Thaís Sant’Anna | https://www.bodyworkmovementtherapies.com/article/S1360-8592(24)00388-7/abstract | A significant difference was observed in reported fatigue between the study groups. Poisson crude and adjusted models confirmed an association between SARS-CoV-2 exposure and presence of perceived fatigue among the asymptomatic and symptomatic mild COVID-19 groups (PR = 1.33 [95%CI:1.09,1.61], P = 0.004 and PR = 1.26 [95%CI:1.03,1.53], P = 0.026), respectively. | |||||||||||||||||||||
382 | Impact of COVID-19 Disease on the Development of Osteomyelitis of Jaws: A Systematic Review | 2024-07-23 | https://doi.org/10.3390/jcm13154290 | Emmanouil Vardas | https://www.mdpi.com/2077-0383/13/15/4290 | Individuals with pre-existing health conditions such as diabetes mellitus who have been treated for COVID-19 are at an increased risk of developing OMJ (osteomyelitis of the jaw), particularly maxillary fungal osteomyelitis. | |||||||||||||||||||||
383 | Revealing the Hidden Impacts: Insights into Biological Aging and Long-Term Effects in Pauci- and Asymptomatic COVID-19 Healthcare Workers | 2024-07-24 | https://doi.org/10.3390/ijms25158056 | Manuela Campisi | https://www.mdpi.com/1422-0067/25/15/8056 | HCWs exhibited accelerated biological aging in IS (induced sputum) cells compared to both blood leukocytes (p ≤ 0.05) and NCs (p < 0.001) and were biologically older than COPD patients (p < 0.05). These findings suggest the need to monitor aging in pauci- and asymptomatic COVID-19 survivors. | |||||||||||||||||||||
384 | Long-term outcome of patients with diabetic-range hyperglycemia first detected during admission for COVID-19: A single-center observational study | 2024-07-26 | https://doi.org/10.4103/jfmpc.jfmpc_140_24 | Ketan Agarwal | https://pubmed.ncbi.nlm.nih.gov/39228533/ | Out of 86 patients, ten (11.6%) were found to have developed diabetes, and 13 (15.1%) had pre-diabetes on follow-up. About 63 (73.3%) patients had become normoglycemic. While a majority of post-COVID patients with diabetic-range hyperglycemia returned to a normoglycemic state after the acute illness had settled down, one in ten developed new-onset diabetes, and an additional one in seven had impaired glucose tolerance. | |||||||||||||||||||||
385 | A Comparative Study on the Pain Threshold Experienced by Fibromyalgia Patients Following Acute SARS-CoV-2 Infection | 2024-07-27 | https://doi.org/10.3390/life14080942 | Daniela Matei | https://www.mdpi.com/2075-1729/14/8/942 | The non-COVID-19 patient groups showed a statistically significant reduction in pain at the final evaluation compared to patients with a history of acute SARS-CoV-2 infection. Patients without COVID-19 infection and that were vaccinated exhibited the best improvement in pain threshold, both across evaluation times and compared to any of the other three groups studied. | |||||||||||||||||||||
386 | Immuno-inflammatory and organ dysfunction markers in severe COVID-19 patients | 2024-07-27 | https://doi.org/10.1016/j.cyto.2024.156715 | Najat Jabbar Ahmed | https://www.sciencedirect.com/science/article/abs/pii/S1043466624002187 | The effect of SARS CoV-2 and cytokine storm was clear on the body’s organs through vital biomarker investigations that were performed in this study. | |||||||||||||||||||||
387 | Incidence of hearing loss following COVID-19 among young adults in South Korea: a nationwide cohort study | 2024-07-29 | https://doi.org/10.1016/j.eclinm.2024.102759 | Hye Jun Kim | https://www.sciencedirect.com/science/article/pii/S2589537024003389 | Our findings suggest a heightened risk of HL and SSNHL following COVID-19 in young adults. The risk of HL (hearing loss) (incidence: 11.9 versus 3.4/10,000 PMs; SHR, 3.51) and SSNHL (sudden sensorineural hearing loss) (incidence: 1.8 versus 0.5/10,000 PMs; SHR, 3.58) was higher in COVID-19 group as compared to no COVID-19 group. | |||||||||||||||||||||
388 | COVID-19 and menstrual-related disturbances: a Spanish retrospective observational study in formerly menstruating women | 2024-07-29 | https://doi.org/10.3389/fgwh.2024.1393765 | María González | https://www.frontiersin.org/journals/global-womens-health/articles/10.3389/fgwh.2024.1393765/full | 38.8% of participants experienced menstrual-related disturbances following COVID-19. Among these, unexpected vaginal bleeding (20.8%) was the most common event, followed by spotting (11.1%) ( Table 1). Other reported changes were in the length (shorter = 12.5%) and flow (heavier = 30.3%) of menstrual bleeding in comparison to their previous experience. | |||||||||||||||||||||
389 | A follow-up study of post-COVID-19 syndrome in hospitalized children with Omicron variant infection in Wuhan | 2024-07-31 | https://doi.org/10.3389/fped.2024.1359057 | Chunjiao Tang | https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1359057/full | After three follow-ups, 49.1% patients had PCS, while the incidence of PCS persisting 3 month was 21.4%, with a prevalence of PCS persisting 6 month of 10.7%. | |||||||||||||||||||||
390 | Clinical Characterization of New-Onset Chronic Musculoskeletal Pain in Long COVID: A Cross-Sectional Study | 2024-07-31 | https://doi.org/10.2147/jpr.s466294 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc11298172/ | Omar Khoja | https://pubmed.ncbi.nlm.nih.gov/39100135/ | New-onset chronic MSK (musculoskeletal ) pain in LC (Lo n g COVID) tends to be widespread, constant, and associated with weakness, reduced function, depression, anxiety, and reduced quality of life. There is associated central sensitization and proinflammatory state in the condition. | ||||||||||||||||||||
391 | Outcomes and Clinical Profiles of Health Care Workers who Recovered from COVID-19: A Cross-sectional Study on Follow-up and Post-COVID-19 Syndrome | 2024-07-31 | https://doi.org/10.47895/amp.v58i13.8083 | Shiela Marie S. Laviña | https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/8083 | Persistent symptoms reported several months post-recovery from COVID-19 included fatigue (25%), difficulty of breathing (23%), muscle weakness (16%), nasal congestion (12%), cough (10%), sore throat (5%), anosmia (3%), and ageusia (2%). Symptoms of physical and mental fatigue post-COVID-19 were reported by 25% (N = 93) with extreme fatigue reported by four staff. Fifteen percent (N = 57) reported that they feel that their workload or schedule needed modification after recovery. | |||||||||||||||||||||
392 | The association of non-severe COVID-19 infection and progression to frailty among robust older veterans | 2024-08-01 | https://doi.org/10.1016/j.jnha.2024.100296 | Natasha M. Resendes | https://www.sciencedirect.com/science/article/pii/S127977072400383X | Non-severe COVID-19 infection that occurred in robust older adults increased the risk of developing frailty... Over the follow up period of 36 months, testing positive for COVID-19 was associated with a 66% increase in the hazard of becoming frail (adjusted HR = 1.66, 95%CI: 1.32–2.08), and a 68% increase in the hazard of becoming pre-frail (adjusted HR = 1.68, 95%CI: 1.45–1.94). | |||||||||||||||||||||
393 | Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people | 2024-08-01 | https://doi.org/10.1016/S2213-8587(24)00159-1 | Kurt Taylor | https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00159-1/fulltext | Elevated incidence of type 2 diabetes after COVID-19 is greater, and persists for longer, in people who were hospitalised with COVID-19 than in those who were not, and is markedly less apparent in people who have been vaccinated against COVID-19. aHRs were higher in unvaccinated people (8·76) than in vaccinated people (1·66) in weeks 1–4 and in patients hospitalised with COVID-19 (pre-vaccination cohort 28·3 in weeks 1–4 declining to 2·04 in weeks 53–102) than in those who were not hospitalised (1·95 in weeks 1–4 declining to 1·11 in weeks 53–102). | |||||||||||||||||||||
394 | Osteonecrosis as a manifestation of Long-COVID Syndrome: a systematic review | 2024-08-01 | https://doi.org/10.1007/s12306-024-00854-w | P. Za | https://link.springer.com/article/10.1007/s12306-024-00854-w | Patients with a history of COVID-19 infection developed osteonecrosis prematurely and with a lower dose of CCS (corticosteroids ) than usually reported in the literature. | |||||||||||||||||||||
395 | Acute and long COVID-19 symptoms and associated factors in the omicron-dominant period: a nationwide survey via the online platform Wenjuanxing in China | 2024-08-01 | https://doi.org/10.1186/s12889-024-19510-w | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc11295386/ | Zheng Su | https://pubmed.ncbi.nlm.nih.gov/39090598/ | Among 3983 COVID-19 patients with 3 months or more time difference between first infection and participation into the study, the long COVID-19 rate was 19.68% and the primary symptoms were muscle weakness (19.39%), headache (17.98%) and smell/taste disorder (15.18%). | ||||||||||||||||||||
396 | Reversible central adrenal insufficiency in survivors of COVID-19: results from a 24-month longitudinal study | 2024-08-01 | https://doi.org/10.1530/EC-24-0086 | Saroj Kumar Sahoo | https://www.sciencedirect.com/org/science/article/pii/S2049361424000820 | Central AI (Adrenal insufficiency) was common during acute COVID-19 and at 12 months of follow-up. At 12 months, AI was seen in 13% (12/90) patients, with all cases being hypothalamic–pituitary in origin; five (42%) of them had not met the diagnostic criteria for AI during COVID-19. | |||||||||||||||||||||
397 | Clinico-radiological and pulmonary function assessment of post-COVID-19 patients with respiratory symptoms | 2024-08-01 | 10.4103/jfmpc.jfmpc_1721_23 | Behera, Nilakantha | https://journals.lww.com/jfmpc/fulltext/2024/13080/clinico_radiological_and_pulmonary_function.16.aspx | C-reactive protein (CRP) and D-dimer were increased in 38.6% and 32% of patients, respectively. 42.6% had abnormal chest X-ray, and the most common abnormal finding was reticular thickening. In spirometry, the restrictive pattern and mixed pattern were the predominant types documented in 49.3% and 13.3% of cases, respectively, which were significant in the moderate–severe group. High-resolution computed tomography (HRCT) of the thorax was abnormal in 55.7% with the most common abnormalities as inter- and intra-lobular septal thickening. | |||||||||||||||||||||
398 | Oculomotor Behaviour in Individuals with Long COVID-19 | 2024-08-02 | https://doi.org/10.1177/02692155241265886 | L González-Vides | https://pubmed.ncbi.nlm.nih.gov/39094376/ | Data showed a lower performance in oculomotor behaviour in people with long COVID-19, compared to healthy individuals. It cannot be affirmed an ocular musculature dysfunction; the differentiated behaviour could be associated to cognitive alterations affected in these people. | |||||||||||||||||||||
399 | Pulmonary Function, Functional Capacity, Respiratory, and Locomotor Muscle Strength after Severe to Critically Ill COVID-19: A Long-Term Study | 2024-08-02 | https://doi.org/10.4046/trd.2024.0044 | Thanunya Ngamsutham | https://e-trd.org/journal/view.php?doi=10.4046/trd.2024.0044 | Pulmonary function, functional capacity, respiratory, and locomotor muscle strength of survivors from COVID-19 were impaired and recovery was observed after three to six months. | |||||||||||||||||||||
400 | Peripheral and brainstem auditory evaluation in post-COVID-19 individuals | 2024-08-03 | https://doi.org/10.1016/j.clinsp.2024.100472 | Lucas Pinto Mielle | https://pubmed.ncbi.nlm.nih.gov/39098145/ | Thirteen individuals (29.5 %) had some hearing threshold impairment, mainly sensorineural hearing loss. In the BAEP (Brainstem Auditory Evoked Potentials), 18 individuals (40.9 %) presented longer latencies, mainly in waves III and V. According to the questionnaire answers, 3 individuals (9.1 %) reported worsened hearing and 7 (15.9 %) tinnitus that emerged after the infection. | |||||||||||||||||||||
401 | The incremental impact of comorbidities in COVID-19-related deaths compared to patients dying from cancer or cardiovascular disease | 2024-08-05 | https://doi.org/10.1186/s43162-024-00348-y | Laura Pighi | https://link.springer.com/article/10.1186/s43162-024-00348-y | Although the proportion of deaths in patients with more than one comorbidity increased progressively for all three pathologies, the ratio ranged from 4.8 to 12.1 for cardiovascular disease, from 5.0 to 12.5 for cancer, while the ratio for COVID-19 increased exponentially from 9.3 in patients with two comorbidities up to 136.7 in patients with six or more comorbidities. | |||||||||||||||||||||
402 | Exploring the prevalence and chest CT predictors of Long COVID in children: a comprehensive study from Shanghai and Linyi | 2024-08-06 | https://doi.org/10.3389/fped.2024.1420196 | Yong Yin | https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1420196/full | Long COVID in children presents a complex challenge with a significant prevalence rate of 23.1%. Chest CT scans of children post-SARS-CoV-2 infection, identified as abnormal with increased vascular markings, indicate a higher risk of developing Long COVID. | |||||||||||||||||||||
403 | Liver dysfunction in adults with COVID-19 infection: A longitudinal study with transient elastography evaluation | 2024-08-07 | https://doi.org/10.1002/jgh3.13118 | Ruveena Bhavani Rajaram | https://onlinelibrary.wiley.com/doi/10.1002/jgh3.13118 | Approximately 47.7% of COVID-19 patients were found to have persistent ALB (Abnormal liver biochemistry) up to 6 months following the acute infection, and it was associated with raised BMI, elevated serum LDL, increased rates of MAFLD (metabolic-associated fatty liver disease) and CLD (chronic liver disease), and higher rates of liver injury on univariate analysis | |||||||||||||||||||||
404 | Association of COVID-19 Infection and the Risk of New Incident Diabetes: a Systematic Review and Meta-analysis | 2024-08-08 | https://doi.org/10.3389/fendo.2024.1429848 | JINGYE ZHOU | https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1429848/abstract | COVID-19 infection is associated with an elevated risk of new incident diabetes. The pooling analysis illustrates the association between COVID-19 infection and an increased risk of new incident diabetes (HR = 1.46). The risk of incident diabetes is associated with hospitalization: non-hospitalized patients have an HR of 1.16 (95% CI: 1.07-1.26), normal hospitalized patients have an HR of 2.15, and patients receiving intensive care have the highest HR of 2.88. | |||||||||||||||||||||
405 | Prevalence, risk factors and characterisation of individuals with long COVID using Electronic Health Records in over 1.5 million COVID cases in England | 2024-08-08 | https://doi.org/10.1016/j.jinf.2024.106235 | Han-I Wang | https://www.journalofinfection.com/article/S0163-4453(24)00169-5/fulltext | During an average 400-day follow-up, 7.4% of individuals with COVID had at least one long-COVID symptom after acute phase, yet only 0.5% had long-COVID diagnostic codes. The most common long-COVID symptoms included cough (17.7%), back pain (15.2%), stomach-ache (11.2%), headache (11.1%), and sore throat (10.0%). The same trend was observed in all three subgroups (hospitalised, non-hospitalised, and untreated COVID cases). | |||||||||||||||||||||
406 | Orthostatic Intolerance in Children With Long COVID Utilizing a 10-Minute Passive Standing Test | 2024-08-09 | https://doi.org/10.1177/00099228241272053 | Amanda K. Morrow | https://journals.sagepub.com/doi/10.1177/00099228241272053 | This study examines rates of OI (Orthostatic Intolerance) in 92 children with long COVID who underwent a bedside passive standing test in a pediatric post-COVID-19 rehabilitation clinic. Seventy-one percent met criteria for an orthostatic condition, including postural orthostatic tachycardia syndrome (POTS), orthostatic tachycardia (OT), classic orthostatic hypotension (OH), delayed OH, and orthostatic hypertension. | |||||||||||||||||||||
407 | Excess risks of long COVID symptoms compared with identical symptoms in the general population: A systematic review and meta-analysis of studies with control groups | 2024-08-12 | https://doi.org/10.7189/jogh.14.05022 | 39129538 | Zijun Xu | https://pubmed.ncbi.nlm.nih.gov/39129538/ | We found that COVID-19 can significantly increase the risk of many long COVID symptoms, without differences due to gender, age, or decrease over time after three months post-infection. In the primary analysis, participants with COVID-19 had a significantly higher risk of having at least one long COVID symptom (OR = 2.032; 95% CI = 1.787-2.310). | ||||||||||||||||||||
408 | Causal associations between severe COVID-19 and diseases of seven organs: a proteome-wide mendelian randomization study | 2024-08-12 | https://doi.org/10.3389/fgene.2024.1421824 | Yunhan Shen | https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1421824/full | Our findings have confirmed the association between severe COVID-19 and multiple organ-related diseases, such as Hypothyroidism, strict autoimmune (HTCBSA), Thyroid disorders (TD), and Graves’ disease (GD). Tthere was a causal association between severe COVID-19 and liver diseases (OR and 95% CI: 0.906,0.82 to 0.99; p = 0.038). A corresponding causal relationship between severe COVID-19 and TD (Thyroid Disease) is found (OR and 95%CI: 0.919, 0.85 to 1.00; p = 0.046). | |||||||||||||||||||||
409 | Prevalence and Risk Factors of Intensive Care Unit-acquired Weakness in Patients With COVID-19: A Systematic Review and Meta-analysis | 2024-08-14 | https://doi.org/10.1177/08850666241268437 | 39140376 | Ya-Chi Chuang | https://pubmed.ncbi.nlm.nih.gov/39140376/ | The prevalence of ICUAW (Intensive care unit acquired weakness) in patients with COVID-19 was considered relatively high. The pooled prevalence of ICUAW in COVID-19 patients was 55% in eight studies on 868 patients. | ||||||||||||||||||||
410 | Predictors of 2-year mortality in geriatric patients hospitalized with COVID-19 in Türkiye: a retrospective cohort study | 2024-08-14 | https://doi.org/10.1080/17520363.2024.2352416 | 39140394 | Bahar Bektan Kanat | https://pubmed.ncbi.nlm.nih.gov/39140394/ | The 2-year post-discharge mortality rate of 605 patients was 21.9%. Mean age of patients in the deceased group was 76.8 ± 8.1 years, which was shorter than the life expectancy at birth in Türkiye. The higher 2-year mortality in cancer patients suggested that cancer patients may have died due to their underlying disease or that COVID-19 infection may have accelerated the process of cancer-related death. | ||||||||||||||||||||
411 | Protracted exercise tolerance post-coronavirus disease 2019 in endurance athletes: A survey | 2024-08-14 | https://doi.org/10.4102/sajp.v80i1.2063 | Cheryl A. Haley | https://sajp.co.za/index.php/sajp/article/view/2063 | Almost one-third of endurance athletes suffered protracted exercise tolerance post-COVID-19. Long-term symptoms may be more consequential in this athlete population.The group that did not return to their pre-illness level of sport (31.5%) had more post-COVID sequelae, worse illness severity, with a higher frequency of resting and exertional symptoms, notably fatigue and dyspnoea. Decreased exercise capacity was correlated with increased physical fatigue scores. | |||||||||||||||||||||
412 | Long-term Health Outcomes After Hospital Discharge Among Children Hospitalized for MIS-C or COVID-19, September 29, 2021, to June 21, 2022 | 2024-08-15 | https://doi.org/10.1097/INF.0000000000004477 | Godfred-Cato, Shana | https://journals.lww.com/pidj/abstract/9900/long_term_health_outcomes_after_hospital_discharge.982.aspx | Approximately 20% of children with MIS-C and COVID-19 continued to have symptoms including fatigue and headache >1 year after hospital discharge. Full mental recovery at the time of survey 2 (median, 16 months post-hospitalization for patients with MIS-C and 20 months for patients with COVID-19) was 85% and 88%, respectively; full physical recovery was 87% and 81%, respectively. Fatigue persisted >1 year in 15%–20% of patients in both groups. | |||||||||||||||||||||
413 | Long-term recovery of taste and smell following acute COVID-19 infection in a New Jersey cohort | 2024-08-15 | https://doi.org/10.1016/j.sctalk.2024.100390 | Samuel C.Z. Gautier | https://www.sciencetalks-journal.com/article/S2772-5693(24)00098-7/fulltext | Total overall smell score significantly improved from baseline to 6-month follow up (6.9 ± 1.4 vs 7.6 ± 0.8; p = .01). Taste intensity also improved across 6 months, but not significantly. Sixty-six point six percent of participants self-reported improved taste and smell. | |||||||||||||||||||||
414 | Health outcomes of COVID-19 patients from Wuhan, China 3-year after hospital discharge: a cohort study | 2024-08-17 | https://doi.org/10.1136/bmjopen-2024-084770 | Yang Dai | https://bmjopen.bmj.com/content/14/8/e084770 | 3 years after discharge, 182 (11.4%) patients still complained of at least one symptom. The most common symptoms were fatigue, myalgia, chest tightness, cough, anxiety, shortness of breath and expectoration. Symptom persistence between years 2 and 3 was reported in 70 patients (4.4%) for which intensive care unit (ICU) admission was a risk factor (p=0.038). | |||||||||||||||||||||
415 | COVID-19’s Radiologic, Functional, and Serologic Consequences at 6-Month and 18-Month Follow-up: A Prospective Cohort Study | 2024-08-19 | https://doi.org/10.3346/jkms.2024.39.e228 | Cherry Kim | https://jkms.org/DOIx.php?id=10.3346/jkms.2024.39.e228 | CT abnormalities were noted in 22 participants (32.4%) at 6 months and 13 participants (31.0%) at 18 months. At 18-month follow-up assessments, 31.0% of participants exhibited residual CT (computed tomography) abnormalities. Age and higher SARS-CoV-2 IgG (immunoglobulin G) levels were significant predictors, and FVC (forced vital capacity) was related to abnormal CT findings at 18 months. | |||||||||||||||||||||
416 | Systemic oxidative stress associates with the development of post-COVID-19 syndrome in non-hospitalized individuals | 2024-08-19 | https://doi.org/10.1016/j.redox.2024.103310 | Larissa E Vlaming-van Eijk | https://pubmed.ncbi.nlm.nih.gov/39163767/ | Non-hospitalized individuals with COVID-19 show evidence of systemic oxidative stress, which is longitudinally associated with the development of PCS (Post-COVID-19 syndrome). Baseline albumin-adjusted serum R-SH were significantly reduced in non-hospitalized COVID-19 subjects as compared to HC reflecting systemic OS (Systemic oxidative stress). In mild COVID-19 subjects, trajectories of albumin-adjusted serum R-SH levels over a course of 12 months were longitudinally associated with the future presence of PCS 18 months after initial infection. | |||||||||||||||||||||
417 | The development of depression and social anxiety symptoms in adolescents and the negative impact of the COVID-19 pandemic and desire for peer contact | 2024-08-19 | https://doii.org/10.3389/fpubh.2024.1374327 | Anne Pinkse-Schepers | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1374327/abstract | The increase in depression was greater in a cohort who experienced the COVID-19 pandemic. | |||||||||||||||||||||
418 | Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study | 2024-08-20 | https://doi.org/10.1186/s13148-024-01724-9 | Calzari Luciano | https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-024-01724-9 | Dysregulated genes highlighted potential links to glutamate/glutamine metabolism, which may be relevant to PASC symptoms. Furthermore, Horvath's epigenetic clock showed a slight but significant age acceleration in post-COVID-19 patients. We also observed a substantial increase in stochastic epigenetic mutations (SEMs) in the post-COVID-19 group, implying potential epigenetic drift. SEM analysis identified 790 affected genes, indicating dysregulation in pathways related to insulin resistance, VEGF signaling, apoptosis, hypoxia response, T-cell activation, and endothelin signaling. | |||||||||||||||||||||
419 | Children with previous COVID-19 infection are more likely to present with recurrent acute otitis media or tube otorrhea | 2024-08-20 | https://doi.org/10.1016/j.ijporl.2024.112072 | Beatrice R. Bacon | https://www.sciencedirect.com/science/article/abs/pii/S016558762400226X | Infection with COVID-19 may be associated with an increased risk of rAOM (recurrent acute otitis media) and VTO (post-ventilation tube otorrhea) in children. 104 (19.8 %) had a diagnosis of rAOM or VTO, 26.1 % (30/115) children in C19 and 18.1 % (74/409) children in NoC19 (Fisher's Exact p = .04, OR = 1.6). For children without ventilation tubes in place, 23.5 % (27/115) in C19 had rAOM versus 15.2 % (62/409) in NoC19 (p = .03, OR = 1.7). 18.3 % (21/115) of the C19 group had nasal congestion compared to 6.6 % (27/409) of the NoC19 group (p < .001, OR = 3.2). | |||||||||||||||||||||
420 | Soluble IL-2R impairs muscle cell mitochondrial respiration in fatigued individuals with post-acute sequelae of COVID-19 | 2024-08-20 | https://doi.org/10.1101/2024.08.14.24311980 | Laura Peterson Brown | https://www.medrxiv.org/content/10.1101/2024.08.14.24311980v2 | We conducted a cross-sectional case-control study of patients with fatigue-associated PASC who had experienced mild to moderate COVID-19 without hospitalization. Skeletal muscle biopsies revealed reduced mitochondrial respiration and content in PASC participants compared to healthy controls. | |||||||||||||||||||||
421 | The Impact of SARS-CoV-2 Infection on Sleep, Daytime Sleepiness, and Depression—Longitudinal Cohort Study | 2024-08-20 | https://doi.org/10.3390/medicina60081352 | Klāvs Putenis | https://www.mdpi.com/1648-9144/60/8/1352 | People treated at home had worse sleep quality and more depressive symptoms six months after infection indicating worse life quality. Six months after SARS-CoV-2 infection, home-treated patients reported a higher prevalence of poor sleep quality (52.8%, n = 19, p = 0.015, PSQI) and hospitalised patients showed a lower prevalence of depressive symptoms (p < 0.001, PHQ-9) as 90% (n = 27) had minimal or no symptoms compared to 30.6% (n = 11) in a home-treated group. | |||||||||||||||||||||
422 | Characterizing Long COVID in Children and Adolescents | 2024-08-21 | https://doi.org/10.1001/jama.2024.12747 | Rachel S. Gross | https://jamanetwork.com/journals/jama/article-abstract/2822770 | 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. | |||||||||||||||||||||
423 | COVID-19 and Mental Illnesses in Vaccinated and Unvaccinated People | 2024-08-21 | https://doi.org/10.1001/jamapsychiatry.2024.2339 | Venexia M. Walker | https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2822342 | In this cohort study, depression, serious mental illness, general anxiety, posttraumatic stress disorder, eating disorders, addiction, self-harm, and suicide were elevated during weeks 1 through 4 after COVID-19 diagnosis compared with before or without COVID-19. Incidence was lower in people who were vaccinated when they had COVID-19 and incidence was higher, and persisted longer, after hospitalization for COVID-19. | |||||||||||||||||||||
424 | The Impact of Long COVID on the Quality of Life | 2024-08-21 | https://doi.org/10.3390/medicina60081359 | Angela Cozma | https://www.mdpi.com/1648-9144/60/8/1359 | The most common symptoms at 2 years (in 29 respondent subjects) were represented by asthenia (51.7%), headache (34.5%), memory disorders (27.6%), abdominal meteorism (27.6%), and arthralgia (27.6%). In terms of cardiovascular symptoms, fluctuating blood pressure values (20.7%), palpitations (17.2%), and increased heart rate values (17.2%) were recorded. | |||||||||||||||||||||
425 | Quality of sleep after COVID-19 infection: a cross-sectional study in the south of Italy | 2024-08-21 | https://doi.org/10.3389/fpsyt.2024.1428423 | Vincenza Sansone | https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1428423/abstract | 66.4% had a reduction in social relations and 72.1% had an increase in the use of social media, 86%, 77.2%, and 71.1% reported an extremely severe level of anxiety, stress, and depression, respectively. Almost all of the respondents have had a Pittsburgh Sleep Quality Index score (PSQI) ≥5, indicating poor sleep quality. | |||||||||||||||||||||
426 | SUDDEN SENSORINEURAL HEARING LOSS: AUDIOLOGICAL PROFILE DURING THE COVID-19 PANDEMIC | 2024-08-22 | https://doi.org/10.3389/fneur.2024.1415068 | Kelly A. Peron | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1415068/abstract | Infection with SARS-CoV-2 resulted in more severe SSNHL (Sudden sensorineural hearing loss), in bilateral SSNHL, and in poorer recovery from SSNHL in bilateral cases. Bilateral SSNHL was seen more frequently in patients who had not received vaccination against COVID-19. | |||||||||||||||||||||
427 | Small Airways Dysfunction and Lung Hyperinflation in Long COVID-19 Patients as Potential Mechanisms of Persistent Dyspnoea | 2024-08-23 | https://doi.org/10.3390/arm92050031 | Angelos Vontetsianos | https://www.mdpi.com/2543-6031/92/5/31 | Long COVID-19 patients present with small airways dysfunction and lung hyperinflation, which is associated with persistent dyspnoea, following hospitalisation. In total, 33 patients with long COVID-19 were recruited 149 ± 90 days following hospital discharge.CC (closing capacity) was abnormal in 13 patients (39%), CV (closing volume) in 2 patients (6.1%) and OC (open capacity) in 9 patients (27%). | |||||||||||||||||||||
428 | Symptoms, Course, and Factors Related to Long-Term Morbidity, Including Differences between Infection Strains, in Patients with Long COVID in a Primary Care Clinic in Japan: An Observational Study | 2024-08-24 | https://doi.org/10.3390/jcm13175019 | Kenji Baba | https://www.mdpi.com/2077-0383/13/17/5019 | We found that half of the patients required more than 169 days to return to their normal social life, with the factors of obesity and dyspnea prolonging the time to remission, but the clinical course was found to be less affected by the infectious strain. | |||||||||||||||||||||
429 | Returning to work and health status at 12 months among patients with COVID-19 cared for in intensive care—A prospective, longitudinal study | 2024-08-24 | https://doi.org/10.1016/j.iccn.2024.103806 | Ewa Wallin | https://www.sciencedirect.com/science/article/pii/S0964339724001915 | Two-thirds of the participants were able to return to work within 1 year after discharge from the ICU. The primary factors contributing to the failure to work were duration of the acute disease and presence of severe and persistent long-term symptoms. | |||||||||||||||||||||
430 | The impact of COVID-19 infection on musculoskeletal pain and its associating factors: a cross-sectional study | 2024-08-26 | https://doi.org/10.3389/fpubh.2024.1422659 | Hongyan Li | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1422659/full | A significant proportion of individuals experience MSPC. A total of 1,510 participants responded to the survey, with 42.6% (643 individuals) exhibiting MSPC (musculoskeletal pain associated with COVID-19). | |||||||||||||||||||||
431 | New Onset Diabetes After COVID 19 (NODAC) is predominantly due to exacerbated Insulin Resistance (IR) rather than beta cell dysfunction: Lessons from tertiary care hospital data during confluence of two epidemics | 2024-08-27 | https://doi.org/10.1007/s12020-024-04006-9 | Juhi Jamwal | https://link.springer.com/article/10.1007/s12020-024-04006-9 | Patients with NODAC (new onset diabetes after COVID-19) have evidence of persistence insulin resistance on follow up. Patients with NODAC had higher mean fasting blood glucose (FBG), random blood glucose (RBG) and HbA1c at baseline as compared to COVID with euglycemic group with no difference in serum C-peptide levels. | |||||||||||||||||||||
432 | Patient-Reported Experiences of Persistent Post–COVID-19 Conditions After Hospital Discharge During the Second and Third Waves of the Pandemic in Switzerland: Cross-Sectional Questionnaire Study | 2024-08-28 | https://doi.org/10.2196/47465 | Nadine Tacchini-Jacquier | https://publichealth.jmir.org/2024/1/e47465 | The majority of inpatients infected with SARS-CoV-2 presented with PCC 4 months after discharge, with complex clinical pictures. Only one-third of them were symptom-free during that time. Only 28.2% (69/245) of respondents were symptom-free after 4 months. Three-fourth (187/245, 76.4%) of the respondents reported memory loss and concentration disorders (Q3PC). | |||||||||||||||||||||
433 | Insulin Resistance in Long COVID-19 Syndrome | 2024-08-28 | https://doi.org/10.3390/jpm14090911 | Dana Emilia Man | https://www.mdpi.com/2075-4426/14/9/911 | More than one-third (30.7%) of the included patients developed long COVID-19 syndrome. It was found that 75% of patients with long COVID-19 hospitalized in our clinic developed diabetes within a year of acute infection with COVID-19; therefore, it can be said that the presence of long COVID-19 is a major risk for an altered metabolic status, which can cause diabetes. | |||||||||||||||||||||
434 | Prevalence and impact of persistent symptoms following SARS-CoV-2 infection among healthcare workers: a cross-sectional survey in the SIREN cohort | 2024-08-28 | https://doi.org/10.1016/j.jinf.2024.106259 | Sarah Foulkes | https://www.sciencedirect.com/science/article/pii/S0163445324001932 | Persistent symptoms were frequent in our cohort and there was a reduction in symptom duration in those with multiple infection episodes, during later variants periods and post-vaccination. About half of participants reported that their persistent symptoms impacted their day-today (51.8%) and work-related (42.1%) activities ‘a little’ and 24.0% and 14.4% reported that the impact was ‘A lot’. 8.9% reported they had reduced their working hours and 13.9% had changed their working pattern. | |||||||||||||||||||||
435 | Long COVID symptoms and demographic associations: A retrospective case series study using healthcare application data | 2024-08-28 | https://doi.org/10.1177/20542704241274292 | David Sunkersing | https://journals.sagepub.com/doi/10.1177/20542704241274292 | 109 symptom categories were identified, with pain (26.5%), neuropsychological issues (18.4%), fatigue (14.3%) and dyspnoea (7.4%) the most prevalent. The intensity of reported symptoms increased by 3.3% per month since registration. | |||||||||||||||||||||
436 | Findings Associated with Prolonged COVID-19 Recovery among Boston Healthcare Workers | 2024-08-29 | https://doi.org/10.1097/JOM.0000000000003221 | Zalaquett, Nader | https://journals.lww.com/joem/abstract/9900/findings_associated_with_prolonged_covid_19.648.aspx | Among the 280 respondents (15.2% response rate), those with long COVID (73.4%) reported significantly worse quality of life and greater levels of depression, anxiety, and stress metrics. However, no significant difference was found between the two groups’ fear of COVID-19. | |||||||||||||||||||||
437 | A Journey Through Grief: Experiences of Loss Among Patients With Long COVID | 2024-08-30 | https://doi.org/10.1177/23743735241272267 | Ann Scheck McAlearney | https://journals.sagepub.com/doi/10.1177/23743735241272267 | Long COVID patients (1) reported experiencing loss across multiple domains including loss of physical health, mental health, social support and connections, roles in their families, and self-identities, and (2) described experiences of grief that mirrored the 5 stages of grief in the Kubler-Ross model: denial, anger, bargaining, depression, and for some, acceptance. | |||||||||||||||||||||
438 | Advance in the mechanism and clinical research of myalgia in long COVID | 2024-08-30 | https://doi.org/10.62347/TXVO6284 | Xiuyun Zhai | https://e-century.us/files/ajcei/13/4/ajcei0155121.pdf | The persistent skeletal muscle pain in long COVID is due to abnormal activation of inflammatory response, myopathy, and neurological damage. In addition, dysregulation of the reninangiotensin system, history of musculoskeletal pain, myotoxic drugs, immobility, age, blood group, virus strain, anti-virus drugs and gut microbiome contribute to the development of myalgia in Long COVID. | |||||||||||||||||||||
439 | Analysis of Cultured Gut Microbiota Using MALDI-TOF MS in COVID-19 Patients from Serbia during the Predominance of the SARS-CoV-2 Omicron Variant | 2024-08-30 | https://doi.org/10.3390/microorganisms12091800 | Aleksandra Patić | https://www.mdpi.com/2076-2607/12/9/1800 | Our findings indicate a change in the gut microbiota composition isolated in culture during the initial phase of infection. Additionally, the enrichment of fungal pathogens in fecal samples collected 30 days after the cessation of disease symptoms might suggest a prolonged disruption of the gut microbiota even after the resolution of COVID-19 symptoms. | |||||||||||||||||||||
440 | COVID-19-related liver injury: Mechanisms, diagnosis, management; its impact on pre-existing conditions, cancer and liver transplant: A comprehensive review | 2024-08-31 | https://doi.org/10.1016/j.lfs.2024.123022 | M Vinutha | https://www.sciencedirect.com/science/article/abs/pii/S002432052400612X | COVID-19 impacts liver function through direct viral effects, cytokine storms, and drug-induced liver injury. COVID-19 can cause a spectrum of liver injuries, from mild enzyme elevations to severe hepatic dysfunction. Injury mechanisms include direct viral invasion, immune response alterations, drug toxicity, and hypoxia-reperfusion injury. | |||||||||||||||||||||
441 | Long-Term Corneal Endothelial Parameters of COVID-19 Patients With Ocular Surface Symptoms | 2024-09-01 | 10.1097/ICO.0000000000003552 | Kılıçarslan, Oğuzhan | https://journals.lww.com/corneajrnl/abstract/2024/09000/long_term_corneal_endothelial_parameters_of.9.aspx | COVID-19 can cause long-term alterations in the corneal endothelial cells, leading to decreased ECD (endothelial cell density) and HEX (hexagonality). Ocular symptoms in COVID-19 patients included conjunctival hyperemia, foreign body sensation, tearing, ocular secretion, and chemosis. | |||||||||||||||||||||
442 | Long COVID or Post-Acute Sequelae of COVID-19 (PASC) in Children and Adolescents | 2024-09-01 | doi: 10.3121/cmr.2024.1858 | Djatnika Setiabudi | http://www.clinmedres.org/content/22/3/131 | Most children had long COVID symptoms similar to adults despite being otherwise asymptomatic or having mild COVID-19. Two-thirds developed long COVID symptoms, most frequently in the age 5-9 years group, and mostly fatigue (45.2%), decreased appetite (38.7%), and muscle aches (32.3%). All patients with moderate to severe and more than half asymptomatic to mild COVID-19 developed long COVID. | |||||||||||||||||||||
443 | A cross-sectional survey of ocular problems after COVID-19 infection among healthcare workers at a teaching hospital | 2024-09-01 | https://journals.lww.com/jfmpc/toc/2024/13090 | Mishra, Santosh Kumar | https://journals.lww.com/jfmpc/fulltext/2024/13090/a_cross_sectional_survey_of_ocular_problems_after.25.aspx | The pre-covid ocular problems were present in 25% of the participants, especially in those having chronic diseases (such as diabetes, hypertension, or both). Post-ocular problems were faced by 60% of the participants, which was significant (P < 0.01). Dry eye, itching, and foreign body sensations were present in 60% of those facing ocular problems (P < 0.01). | |||||||||||||||||||||
444 | Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID | 2024-09-02 | https://doi.org/10.1080/15412555.2024.2394129 | Harkiran K. Koonera | https://www.tandfonline.com/doi/full/10.1080/15412555.2024.2394129#abstract | In females with long-COVID, CT airway measurements were consistent with remodelling and similar to those in females with COPD. The remodeling observed here shares similarities with that observed in ex-smokers (thinner airway walls) and patients with COPD (decreased airway lumen, diminished total airway count). Certainly, all of these findings fall along a spectrum, suggesting that although remodeling in long-COVID may not be as advanced as in COPD, it shares similarities which warrant further investigation. | |||||||||||||||||||||
445 | Patients with type 1 diabetes are at elevated risk of developing new hypertension, chronic kidney disease and diabetic ketoacidosis after COVID-19: Up to 40 months’ follow-up | 2024-09-02 | https://doi.org/10.1111/dom.15900 | Shiv Mehrotra-Varma | https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15900 | T1D (type 1 diabetes) patients with COVID-19 are at higher risk of developing new HTN, CKD and DKA compared to T1D patients without COVID-19. Compared to non-COVID-19 patients, both H-COVID-19 (hospitalized) (aHR = 7.55) and NH-COVID-19 (non-hospitalized) (aHR = 5.0) patients were more likely to develop new HTN (hypertension). Compared to non-COVID-19 patients, both H-COVID-19 (aHR = 9.76) and NH-COVID-19 (aHR = 6.54) patients were more likely to develop new CKD (chronic kidney disease). | |||||||||||||||||||||
446 | Somatic, emotional, and gastrointestinal symptom severity are increased among children and adolescents with COVID-19 | 2024-09-02 | https://doi.org/10.1111/nmo.14909 | Joshua B. Wechsler | https://onlinelibrary.wiley.com/doi/10.1111/nmo.14909 | Among symptomatic COVID-19 tested children, we found increased severity of nausea-associated somatic, emotional, and gastrointestinal symptoms in the 3 months following the test that was most increased among patients with a positive COVID-19 test. Both cohorts had increased NP (Nausea Profile) and NSP (nausea severity profile) scores among patients with symptoms prior to COVID-19 testing that was highest among patients with a positive COVID-19 test. | |||||||||||||||||||||
447 | Extracorporeal membrane oxygenation support in adult patients: Comparing COVID-19- and non-COVID-19-associated respiratory failure | 2024-09-02 | https://doi.org/10.1177/02676591241281792 | Tak Kyu Oh | https://pubmed.ncbi.nlm.nih.gov/39222402/ | Despite a higher Charlson Comorbidity index in the non-COVID group, patients with COVID-19 had higher cumulative mortality rates at 6 months and 1 year post-ECMO initiation compared to those with non-COVID-19 respiratory diseases, after adjusting for confounders. Patients with COVID-19 also experienced longer intensive care unit stays, higher hospitalization costs, longer ECMO and mechanical ventilation durations, and lower intensity coverage. | |||||||||||||||||||||
448 | Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection | 2024-09-02 | https://doi.org/10.1016/j.stem.2024.08.007 | Liuliu Yang | https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00293-5 | Proinflammatory macrophages induce β cell pyroptosis through the TNFSF12-TNFRSF12A pathway. β cell death constitutes a pathophysiological cornerstone in the natural progression of diabetes. These findings suggest that macrophage-mediated β cell pyroptosis may contribute to the increased incidence of diabetes among COVID-19 patients. | |||||||||||||||||||||
449 | Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection | 2024-09-02 | https://doi.org/10.1016/j.stem.2024.08.007 | Liuliu Yang | https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00293-5 | Our findings revealed accumulation of proinflammatory macrophages in islets of COVID-19 samples. We also see an increase of CD163+ macrophages in islets of COVID-19 samples, which could be an indication of fibrogenic monocyte infiltration. Fibrosis might also play a role in pancreatitis, new-onset diabetes, and thus β cell damage. Through cell-cell interaction analysis, we found that proinflammatory macrophages induce β cell pyroptosis through the TNFSF12-TNFRSF12A pathway. β cell death constitutes a pathophysiological cornerstone in the natural progression of diabetes. | |||||||||||||||||||||
450 | Two-year epidemiology of post-COVID-19 conditions in Bangladesh: a cohort study of post-COVID-19 from 12,925 SARS-CoV-2 cases between July and December 2021–2023 in Bangladesh | 2024-09-04 | https://doi.org/10.1186/s13690-024-01358-6 | Altaf Hossain Sarker | https://archpublichealth.biomedcentral.com/articles/10.1186/s13690-024-01358-6 | The incidence of PCC was 3.6%, the case-fatality rate was 1.92%, and the recovery rate was 9.0%. Nearly 465 out of 522 people suffering from PCC are persistent and have a significant disability. | |||||||||||||||||||||
451 | Characteristics and predictors of Long Covid in children: a 3-year prospective cohort study | 2024-09-05 | https://doi.org/10.1016/j.eclinm.2024.102815 | Anna Camporesi | https://www.sciencedirect.com/science/article/pii/S2589537024003948 | This is the longest follow-up study of children with SARS-CoV-2 infection, showing a significant and long-lasting burden of Long Covid in the pediatric population. Among the 1296 patients who underwent a 3-month follow-up assessment, 23.2% (301) reported persistent or newly developed symptoms with a negative impact on daily activities, meeting the criteria for Long Covid. 169 (13.2%) patients remained symptomatic at six months, 89 (7.9%) at 12 months, 67 (6.1%) at 18 months, 47 (7.1%) at 24 months. | |||||||||||||||||||||
452 | Impact of COVID-19 pandemic on ocular disease: KNHANES 2015–2021 | 2024-09-05 | https://doi.org/10.1038/s41598-024-70767-y | Hyeon Jung Kim | https://www.nature.com/articles/s41598-024-70767-y | The COVID-19 pandemic was a risk factor for cataracts and AMD (age-related macular degeneration), but not for glaucoma. Risk factors for cataract were COVID-19 pandemic (OR 1.161), hypertension (OR 1.608), diabetes (OR 1.573), dyslipidemia (OR 1.167), stroke (OR 1.272), and depression (OR 1.567). Risk factors for AMD were COVID-19 pandemic (OR 1.600), dyslipidemia (OR 1.610), and depression (OR 1.466). | |||||||||||||||||||||
453 | Diaphragm Muscle Atrophy Contributes to Low Physical Capacity in COVID-19 Survivors | 2024-09-05 | https://doi.org/10.3390/life14091117 | Janusz Kocjan | https://www.mdpi.com/2075-1729/14/9/1117 | Diaphragm muscle dysfunction is a serious long-term post-COVID-19 consequence and can be viewed as a major contributing factor to prolonged functional impairments. We identified that 69.5% of patients had diaphragm atrophy and 6.5% had diaphragm paralysis. Diaphragm functional parameters were strongly associated with selected variables of exercise tolerance, such as distance in the six-minute walk test, oxygen saturation levels, fatigue, and exertion on the Borg scale. | |||||||||||||||||||||
454 | Long COVID symptoms and sleep problems: a population-based study | 2024-09-05 | https://doi.org/10.1111/jsr.14327 | Anna Letícia | https://onlinelibrary.wiley.com/doi/10.1111/jsr.14327 | The prevalence of long COVID was 48.3% and sleep problems were reported by 41.2% of the sample. Individuals with sleep problems were more likely to exhibit altered sensitivity (prevalence ratio [PR] 3.27; 95% CI 1.96–5.45), nasal congestion (PR 2.75; 95% CI 1.53–4.94), musculoskeletal symptoms (PR 1.75; 95% CI 1.48–2.06), respiratory issues (PR 1.58; 95% CI 1.24–2.01), and one or more symptom of long COVID (PR 1.27; 95% CI 1.15–1.39). | |||||||||||||||||||||
455 | Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: insights from prospectively collected data in the BRACE trial | 2024-09-06 | https://doi.org/10.1016/j.jinf.2024.106267 | Ellie McDonald | https://www.journalofinfection.com/article/S0163-4453(24)00201-9/fulltext | Healthcare workers with COVID-19 experienced more severe and longer-lasting symptoms than those with non-COVID-19 respiratory illnesses. Participants with COVID-19 had significantly more severe illness compared to those with non-COVID-19 respiratory illnesses (OR 7·4, 95%CI 5·6-9·7). COVID-19 episodes were up to six times more likely to be prolonged than non-COVID-19 respiratory episodes. | |||||||||||||||||||||
456 | Symptom Persistence Following COVID-19 Infection among an Indigenous Community Residing in the Isthmus of Tehuantepec, Oaxaca, Mexico | 2024-09-07 | https://doi.org/10.3390/jcm13175310 | Araceli Guerra-Martínez | https://www.mdpi.com/2077-0383/13/17/5310 | Among the 201 participants, 90 individuals (66.7% women, 33.3% men) had contracted COVID-19. Out of these, 61 individuals reported persistent symptoms post-infection, with a mean symptom duration of 13.87 months. | |||||||||||||||||||||
457 | Maximal respiratory pressure after COVID-19 compared with reference material in healthy adults: A prospective cohort study (The SECURe study) | 2024-09-08 | https://doi.org/10.14814/phy2.16184 | Thora Wesenberg Helt | https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.16184 | 145 participants were measured median 5 months after COVID-19 diagnosis and of these 16% had reduced MIP (maximal inspiratory pressure) and/or MEP (maximal expiratory pressure) . There was reduced spirometry and total lung capacity, but not reduced diffusion capacity in those with abnormal MIP and/or MEP compared with normal MIP and MEP. Of those with reduced MIP and/or MEP at 5 months, 80% still had reduced MIP and/or MEP at 12 months follow-up. | |||||||||||||||||||||
458 | The Impact of COVID-19 on Functional Capacity and Pulmonary Outcomes in the Hail Region: A Cross-Sectional Study | 2024-09-08 | https://doi.org/10.3390/jcm13185571 | Omar W. Althomali | https://www.mdpi.com/2077-0383/13/18/5571 | In individuals affected with COVID-19 (in the previous 6 months), scores on the minute ventilation, 30 s sit-to-stand, and 6 min walk tests were significantly lower than among healthy individuals. Patients affected by COVID-19 may develop an impaired lung capacity and a decreased function capacity. These factors may negatively affect physical and cognitive health status. | |||||||||||||||||||||
459 | Causal associations between COVID-19 and erectile dysfunction: a Mendelian randomization study | 2024-09-09 | https://doi.org/10.1177/03000605241274236 | Chao Ma | https://journals.sagepub.com/doi/10.1177/03000605241274236 | The results of this comprehensive MR (Mendelian randomization) analysis suggest a negative causal link between COVID-19 hospitalization and total testosterone levels. Nonetheless, COVID-19 (comprising infection, hospitalization, and severe illness) may not directly correlate with an increased risk of ED. These findings imply that COVID-19 may exert a distinct impact on ED through indirect pathways. | |||||||||||||||||||||
460 | SARS-CoV-2 impairs male fertility by targeting semen quality and testosterone level: A systematic review and meta-analysis | 2024-09-09 | https://doi.org/10.1371/journal.pone.0307396 | Ashonibare V. J. | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0307396 | The current study provides compelling evidence that SARS-CoV-2 may lower male fertility by reducing semen quality through a hormone-dependent mechanism; reduction in testosterone level and increase in oestrogen and prolactin levels. The present study demonstrated that SARS-CoV-2 significantly reduced ejaculate volume, sperm count, concentration, viability, normal morphology, and total and progressive motility. Furthermore, SARS-CoV-2 led to a reduction in circulating testosterone level, but a rise in oestrogen, prolactin, and luteinizing hormone levels. | |||||||||||||||||||||
461 | Co-infections and secondary infections amid COVID-19 outbreaks in Vietnam | 2024-09-09 | https://doi.org/10.1186/s12879-024-09866-0 | Hong Tham Pham | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09866-0 | Compared with the non-CoI/ScI group, patients with CoI/ScI (co-infections/secondary infections) had a significantly higher risk of all-cause mortality, regardless of resistance status. These corresponded to higher risks of mortality in the overall CoI/ScI (HR 3.27), bacterial CoI/ScI (HR 3.79), no MDRp CoI/ScI (HR 3.13), and ≥ 1 MDRp CoI/ScI group (HR 3.89). | |||||||||||||||||||||
462 | Investigating the relationship between lymphocyte cells apoptosis and DNA damage and oxidative stress and therapeutic and clinical outcomes of COVID-19 elderly patients | 2024-09-09 | https://doi.org/10.1186/s12879-024-09734-x | Elaheh Abiri | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09734-x | The research results emphasize the potential for serious cell damage and the ongoing hazard that SARS-CoV-2 poses to the older population even after COVID-19 recovery. According to our findings, the SARS-CoV-2 virus is an undiscovered pathogen that can cause lymphocytes to die. Our study discovered that while antioxidant defenses wane, oxidative stress and inflammation are higher in COVID-19 patients. | |||||||||||||||||||||
463 | Characterization of postintensive care syndrome in a prospective cohort of survivors of COVID-19 critical illness: a 12-month follow-up study | 2024-09-09 | https://doi.org/10.1007/s12630-024-02811-4 | Sol Fernández-Gonzalo | https://pubmed.ncbi.nlm.nih.gov/39251486/ | Postintensive care syndrome was common in COVID-19 critical illness survivors and persisted in a significant proportion of patients one year after ICU discharge, impacting HRQoL (health-related quality of life). Fatigue/dyspnea, pain, impaired muscle function, psychiatric symptomatology and reduced physical HRQoL were prominent sequelae early after ICU discharge. Over the 12-month follow-up, functionality and fatigue/dyspnea improved progressively, while pain remained stable. Physical HRQoL scores showed a general improvement over time, whereas mental HRQoL remained stable. | |||||||||||||||||||||
464 | Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood | 2024-09-09 | https://doi.org/10.1101/2024.09.08.611853 | Jong Bhak | https://www.biorxiv.org/content/10.1101/2024.09.08.611853v1 | Our findings reveal profound age acceleration, up to 24.47 years, under perturbed homeostasis in COVID-19 patients, which reverted to baseline upon recovery. In SARS-CoV-2 infection, longitudinal samples showed a mean age acceleration of 24.47 years during the acute phase (95% CI: 11.52 to 37.43, FDR = 0.01). This declined to 11.63 years (95% CI: 4.03 to 19.23, FDR = 0.02) and 5.05 years (95% CI: 0.77 to 9.32, FDR = 0.06) in the mid and late phases, respectively. | |||||||||||||||||||||
465 | Main Predictors of Decreasing in Quality of Life in Patients With Post-COVID-19: A Cross-Sectional Study | 2024-09-09 | https://doi.org/10.1016/j.vhri.2024.101039 | Jonnathan O Cázares-Lara | https://pubmed.ncbi.nlm.nih.gov/39255548/ | Patients with long COVID-19 have decreased QOL mainly associated with pain/discomfort, anxiety/depression, and ≥3 persistent symptoms. In the multivariable analysis, post-COVID-19 pain/discomfort (adjusted odds ratio [aOR] 2.5 [1.66-9.68]; P = .01), anxiety/depression (aOR 13 [1.44-17.23]; P = .03), and persistence of ≥3 symptoms (aOR 2.6 [0.96-7.47]; P = .05) remained statistically significant associated with decreased QOL. | |||||||||||||||||||||
466 | The impact of COVID-19 on the male reproductive system | 2024-09-10 | https://doi.org/10.5935/1518-0557.20240048 | Abzal Kystaubayev | https://pubmed.ncbi.nlm.nih.gov/39254469/ | It was concluded that coronavirus infection can have a negative impact on the male reproductive system. The samples of sperm showed a noticeable decrease in progressive motility, sperm concentration, and volume, especially in patients with moderate and severe symptoms of COVID-19, whereas patients with mild symptoms only experienced a decrease in progressive motility and overall sperm motility. The survey identified symptoms of male reproductive system dysfunction after recovering from COVID-19. Predominant symptoms included decreased libido (15%), impotence (13%), and infections of the genital organs (12%). | |||||||||||||||||||||
467 | New Onset of Acute and Chronic Hepatic Diseases Post-COVID-19 Infection: A Systematic Review | 2024-09-10 | https://doi.org/10.3390/biomedicines12092065 | Ahamed Lebbe | https://www.mdpi.com/2227-9059/12/9/2065 | Common chronic complications that were found in patients’ weeks after their COVID-19 infection included liver steatosis, fibrosis, NAFLD, and chronic liver disease. Complications like hepatitis, acute liver failure, and hemorrhage were observed shortly after recovery. The acute complications are usually severe and should be monitored for patients who recently recovered from COVID-19. Chronic complications, like steatosis, fibrosis, and cirrhosis are typically not as symptomatic; thus, it is important for clinicians to monitor patients for these complications. | |||||||||||||||||||||
468 | Prevalence and factors influencing long COVID among primary healthcare workers after epidemic control policy adjustment in Jiangsu, China | 2024-09-12 | https://doi.org/10.1186/s12879-024-09764-5 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc11396294/ | Hualing Chen | https://pubmed.ncbi.nlm.nih.gov/39266971/ | The prevalence of long COVID among primary HCWs stood at 12.61%, with a 95% confidence interval (CI) of 11.67-13.55%. Among those affected, the most common long COVID symptoms were hypomnesia (4.90%, 95%CI: 4.29-5.51%), sleep difficulties (2.73%, 95%CI: 2.27-3.19%), fatigue (2.35%, 95%CI: 1.92-2.78%), disturbances in the reproductive system (1.93%, 95%CI: 1.54-2.32%), hair loss (1.85%, 95%CI: 1.47-2.23%), and myalgia/arthralgia (1.51%, 95%CI: 1.16-1.86%). | ||||||||||||||||||||
469 | COVID-19 infection and later risk of sickness absence by socioeconomic status: a cohort study | 2024-09-12 | https://doi.org/10.21203/rs.3.rs-5055779/v1 | Matti Joensuu | https://www.researchsquare.com/article/rs-5055779/v1 | Employees who reported contracting COVID-19 infection had higher rates of sickness absence in the next year. A self-reported COVID-19 infection in 2020 was associated with higher subsequent risk of sickness absence in 2021: Adjusted relative risk (RR) compared to those not reporting COVID-19 RR = 1.23, 95% confidence interval (CI) 1.10–1.37 for sickness absence days, 1.29, 1.20–1.39 for short sickness absence spells and 1.20, 1.05–1.37 for long spells. | |||||||||||||||||||||
470 | Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study | 2024-09-13 | https://doi.org/10.3390/biomedicines12092090 | Justyna Siwy | https://www.mdpi.com/2227-9059/12/9/2090 | Our data also suggest that mortality should be considered as one possible symptom or a consequence of post-acute sequelae of SARS-CoV-2 infection, a fact that is currently overlooked. Notably, 13.98% of post-COVID-19 patients succumbed during the follow-up, with mortality rates significantly higher than COVID-19-negative controls, particularly evident in younger individuals (<65 years). These data for the first time demonstrate that SARS-CoV-2 infection highly significantly increases the risk of mortality not only during the acute phase of the disease but also beyond for a period of about one year. | |||||||||||||||||||||
471 | Impact of baseline SARS-CoV-2 load in plasma and upper airways on the incidence of acute extrapulmonary complications of COVID-19: a multicentric, prospective, cohort study | 2024-09-13 | https://doi.org/10.1093/cid/ciae469 | Tomas O Jensen | https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciae469/7756713?login=false | Systemic viral dissemination as evidenced by high plasma N-Ag and high respiratory viral burden are associated with development of EPCs (Extrapulmonary complications) in COVID-19, which in turn are associated with higher 90-day mortality. (20.5%) had at least one EPC. EPCs were associated with higher day-90 all-cause mortality (HR 9.6, 95% CI 7.3, 12.7) after adjustment for other risk factors. | |||||||||||||||||||||
472 | Prevalence of symptoms of post-COVID-19 condition (long COVID) in children hospitalized with COVID-19: A systematic review of observational studies | 2024-09-16 | https://doi.org/10.1002/ppul.27257 | Maíra Machado da Silva | https://onlinelibrary.wiley.com/doi/10.1002/ppul.27257 | In the period between ≥3 months and <12 months after acute COVID-19, the most frequent symptom was exercise intolerance with a pooled prevalence of 29%, followed by nonspecific respiratory symptoms (12%), psychological disorders (10%), and nonspecific gastrointestinal symptoms (10%). In the period ≥12 months after the initial infection, the pooled prevalence of post COVID symptoms was lower, with 6% for exercise intolerance and 3% for fatigue. | |||||||||||||||||||||
473 | Long/post-COVID in children and adolescents: symptom onset and recovery after one year based on healthcare records in Germany | 2024-09-16 | https://doi.org/10.1007/s15010-024-02394-8 | Franz Ehm | https://pubmed.ncbi.nlm.nih.gov/39285063/ | Although very few patients presented symptoms for longer than 12 months, excess morbidity among children and, particularly, adolescents with a history of COVID-19 means a relevant burden for pediatric care. At 0-3 month follow-up, children and adolescents with a previous SARS-CoV-2 infection showed a 34% increased risk of adverse health outcome, and approximately 6% suffered from PASC in association with COVID-19. For most common symptoms, IRRs (incident rate ratios) largely persisted at 9-12 month follow-up. | |||||||||||||||||||||
474 | Insights into Long COVID: Unraveling Risk Factors, Clinical Features, Radiological Findings, Functional Sequelae and Correlations: A Retrospective Cohort Study | 2024-09-17 | https://doi.org/10.1016/j.amjmed.2024.09.006 | Patrizia Pasculli | https://www.amjmed.com/article/S0002-9343(24)00569-2/fulltext | Long-term sequelae are present in a remarkable number of long COVID patients and pose a new challenge to the healthcare system. 82% of patients reported at least one or more symptoms. The most reported symptom was fatigue. Chest CT showed alteration in 76% of patients and pulmonary function alterations were observed in 44.7% of patients. | |||||||||||||||||||||
475 | Self-reported body function and daily life activities 18 months after Covid-19: A nationwide cohort study | 2024-09-18 | https://doi.org/10.1177/14034948241272949 | Johanna Seljelid | https://pubmed.ncbi.nlm.nih.gov/39290084/ | In this nationwide study, more than 8 out of 10 individuals experienced problems with body function 18 months after being on sick leave due to Covid-19, with women and those initially hospitalised reporting more problems. Of 5464 responders (45.7%), 4676 (85.6%) reported experiencing at least one problem with body function, and the reported prevalence of problems with daily life activities was 46%. The most frequently reported problems were fatigue (66.3%), cognition, sleep and movement. | |||||||||||||||||||||
476 | Pediatric Long COVID Subphenotypes: An EHR-based study from the RECOVER program | 2024-09-18 | https://doi.org/10.1101/2024.09.17.24313742 | Vitaly Lorman | https://www.medrxiv.org/content/10.1101/2024.09.17.24313742v1.full-text | We identified a cohort of pediatric (age <21) patients with evidence of Long COVID and no pre-existing complex chronic conditions. The results indicate that cardiorespiratory presentations are most common (present in 54% of patients) followed by subphenotypes marked (in decreasing order of frequency) by musculoskeletal pain, neuropsychiatric conditions, gastrointestinal symptoms, headache, and fatigue. | |||||||||||||||||||||
477 | Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test | 2024-09-19 | https://doi.org/10.1186/s12879-024-09896-8 | Marta Moniz | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09896-8 | Our results suggest that Long COVID is not the same for everyone. In our study, clusters remained similar at 9 and 12 months, except for a slight variation in the frequency of symptoms that composed each cluster. Memory loss, fatigue or weakness and joint pain were the most frequent symptoms reported 9 and 12 months after the positive test. Clusters remained similar in both times, but, within the neurocognitive cluster, memory loss and concentration issues increased in frequency at 12 months. | |||||||||||||||||||||
478 | Comparison of characteristics of children hospitalized for respiratory syncytial virus infection during the pre- and post-COVID-19 eras: a multicenter retrospective study | 2024-09-19 | https://doi.org/10.1186/s12879-024-09783-2 | Hai-Feng Liu | https://link.springer.com/article/10.1186/s12879-024-09783-2 | Older age, more frequent clinical manifestations (fever, acute otitis media, seizures), and elevated laboratory indicators [neutrophil-to-lymphocyte ratio (NLR), c-reactive protein (CRP), interleukin 6 (IL-6), co-infection rate] were identified in the post-COVID-19 group than those in the pre-COVID-19 group (all P < 0.05). Furthermore, compared to the pre-COVID-19 group, the post-COVID-19 group displayed higher rates of SLRTI (severe Lower respiratory tract infection) and mechanical ventilation, with a longer length of hospital stay (all P < 0.05). | |||||||||||||||||||||
479 | Risk of New-Onset Diabetes Before and During the COVID-19 Pandemic: A Real-World Cohort Study | 2024-09-20 | https://doi.org/10.1007/s11606-024-09035-8 | Jithin Sam Varghese | https://link.springer.com/article/10.1007/s11606-024-09035-8 | The pandemic period was associated with increased T2DM (Type 2 Diabetes Mellitus) cases across all socio-demographic subgroups; the greatest risk was observed among individuals exposed to SARS-CoV-2. Relative to the unexposed cohort, the exposed cohort had a higher risk (HR, 1.28 [1.19–1.37]); excess cases, 9.5 [6.4–12.7]). | |||||||||||||||||||||
480 | Prevalence and short-term clinical impacts of new-onset diabetes mellitus among patients with COVID-19 in jazan region, Saudi Arabia | 2024-09-20 | https://doi.org/10.1186/s12902-024-01724-z | Amal H. Mohamed | https://link.springer.com/article/10.1186/s12902-024-01724-z | The prevalence of COVID-19 related new-onset DM (Diabetes Mellitus) was correlated significantly with disease severity and mortality rate. Age, FH (family history), and BMI, were the major predictors. 13.2% were diabetics; 2.2% with preexisting DM and 11.0% had new-onset DM. The overall mortality rate was 2.2%, and it was significantly higher in diabetics in comparison to non-diabetics (P < 0.001). 8.6% had persistent hyperglycemia after 4 months of follow-up. | |||||||||||||||||||||
481 | Physical, cognitive, and social triggers of symptom fluctuations in people living with long COVID: an intensive longitudinal cohort study | 2024-09-20 | https://doi.org/10.1016/j.lanepe.2024.101082 | Darren C. Greenwood | https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(24)00249-7/fulltext | Severity of all symptoms was elevated 30 min after all categories of activity. Increased effort was associated with increased symptom severity. Fatigue severity scores increased by 1.8/10 (95% CI: 1.6–1.9) following the highest physical exertions and by 1.5 (1.4–1.7) following cognitive efforts. | |||||||||||||||||||||
482 | Co-occurrence of psychopathological symptom severity and personality predisposition in post-traumatic stress disorder in patients several months after hospitalisation due to COVID-19 | 2024-09-20 | https://doi.org/10.12740/pp/onlinefirst/183127 | Barbara Bętkowska-Korpała | https://pubmed.ncbi.nlm.nih.gov/39812499/ | There is a co-occurrence of the severity of psychopathological symptoms: anxiety, depression, distress and sleep disorders with the severity of PTSD and its dimensions among patients who have undergone severe COVID-19 in the recent past. 22.5% of patients met the PTSD criteria. | |||||||||||||||||||||
483 | Pulmonary Function Test: A Mainstay for Evaluating Respiratory Health in Patients Recovered from COVID-19 Infection | 2024-09-20 | https://doi.org/10.4103/jpbs.jpbs_780_24 | PMC11805217 | Sanjay Nehe | https://pmc.ncbi.nlm.nih.gov/articles/PMC11805217/ | Even after >3 months of recovery from the COVID-19 acute illness, patients had respiratory complaints like cough and shortness of breath. These convalescent patients also reported to have certain psychological issues like feeling of loneliness, fear, anxiety, and depression. It was noted that all the respiratory parameters of patients even after >3 months of recovery from the COVID-19 acute illness were compromised. | ||||||||||||||||||||
484 | Risk factors for post-coronavirus disease condition in the Alpha-, Delta-, and Omicron-dominant waves among adults in Japan: A population-based matched case-control study | 2024-09-23 | https://doi.org/10.1002/jmv.29928 | Miyuki Hori | https://onlinelibrary.wiley.com/doi/10.1002/jmv.29928 | The prevalence of PCC was 15.0% for cases while that of persistent symptoms was 4.4% for controls; among the cases, it was 27.0% in the Alpha- and Delta-dominant waves and 12.8% in the Omicron-dominant wave. Female sex, comorbidities, and hospitalization were positively associated with PCC. | |||||||||||||||||||||
485 | Long-term Effects of COVID-19 on Sleep Patterns | 2024-09-23 | 10.5152/ThoracResPract.2024.24013 | Salma Batool-Anwar | https://thoracrespract.org/en/long-term-effects-of-covid-19-on-sleep-patterns-132295 | Infection by SARS-CoV-2 was shown to have negative effects on sleep, and a significant proportion of adults experienced insomnia and daytime sleepiness beyond 12 months after recovering from the initial infection. After COVID-19, there was an increase in the percentage of participants reporting difficulty initiating sleep. The sleep symptoms persisted beyond 12 months among 28% of the participants. | |||||||||||||||||||||
486 | COVID-19 and Female Fertility: An Observational Prospective Multicenter Cohort Study: Upholding Reproductive Rights in Emergency Circumstances | 2024-09-24 | https://doi.org/10.3390/diagnostics14192118 | Giuseppe Gullo | https://www.mdpi.com/2075-4418/14/19/2118 | SARS-CoV-2 infection damages female reproductive health, causing significant reductions in AMH (−27.4%) and AFC (−1 antral follicle) values and an increase in FSH (+13.6%) and LH (+13.4%) values. | |||||||||||||||||||||
487 | DNA Damage in Moderate and Severe COVID-19 Cases: Relation to Demographic, Clinical, and Laboratory Parameters | 2024-09-24 | https://doi.org/10.3390/ijms251910293 | Tigran Harutyunyan | https://www.mdpi.com/1422-0067/25/19/10293 | DNA damage was shown to be elevated compared to controls (12.44% vs. 5.09%, p < 0.05). Severe cases showed higher DNA damage than moderate cases (14.66% vs. 10.65%, p < 0.05), and males displayed more damage than females (13.45% vs. 8.15%, p < 0.05). | |||||||||||||||||||||
488 | DNA Damage in Moderate and Severe COVID-19 Cases: Relation to Demographic, Clinical, and Laboratory Parameters | 2024-09-24 | https://doi.org/10.3390/ijms251910293 | Tigran Harutyunyan | https://www.mdpi.com/1422-0067/25/19/10293# | In a combined group of COVID-19 patients, DNA damage was shown to be elevated compared to controls (12.44% vs. 5.09%, p < 0.05). Severe cases showed higher DNA damage than moderate cases (14.66% vs. 10.65%, p < 0.05), and males displayed more damage than females (13.45% vs. 8.15%, p < 0.05). | |||||||||||||||||||||
489 | Gastrointestinal Sequelae of COVID-19: Investigating Post-Infection Complications—A Systematic Review | 2024-09-25 | https://doi.org/10.3390/v16101516 | Ibrahim Mohammed | https://www.mdpi.com/1999-4915/16/10/1516 | The findings emphasize the substantial impact of COVID-19 on the GI tract. The study highlights a broad range of gastrointestinal complications following COVID-19 infection (excluding liver complications, which are examined separately), including inflammatory conditions, such as ulcerative colitis (UC), acute pancreatitis, and multisystem inflammatory syndrome in children (MIS-C). | |||||||||||||||||||||
490 | Functioning of post-COVID-19 patients: a cross-sectional study at the outpatient clinic for long-term effects | 2024-09-25 | https://doi.org/10.1080/02813432.2024.2410986 | Sanna Stålnacke | https://www.tandfonline.com/doi/full/10.1080/02813432.2024.2410986 | In conclusion, patients with PCC had significantly reduced functioning based on WHODAS 2.0 scores and the 6MWT (6-minute walking test) results. The WHODAS 2.0 average total score was 34 (SD 18) (moderate functional limitation) for patients with PCC and 6 (SD 8) (normal or mild limitation) for the controls. The disability was higher in all aspects of WHODAS 2.0 in patients with PCC. | |||||||||||||||||||||
491 | Rates of Sudden Unexpected Infant Death Before and During the COVID-19 Pandemic | 2024-09-26 | 10.1001/jamanetworkopen.2024.35722 | Emma G. Guare | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824101 | In this cross-sectional study of SUID cases from 2018 to 2021, we noted an increase in 2021 SUID and SIDS rates during the COVID-19 pandemic, with a significant epidemiologic shift from the prepandemic period. The risk of SUID and SIDS increased during the intrapandemic period (March 2020 to December 2021) compared with the prepandemic period (March 2018 to December 2019), with the greatest increases noted in 2021 (9% for SUID and 10% for SIDS). | |||||||||||||||||||||
492 | Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID | 2024-09-26 | https://doi.org/10.1183/13993003.01947-2023 | Firoozeh V. Gerayeli | https://erj.ersjournals.com/content/early/2024/09/10/13993003.01947-2023 | The single cell transcriptomic landscape of the PLC airways in patients who were more than 10 months post-acute infection showed an increase in the number of neutrophils along with upregulation in the neutrophil-associated activation signature and its related inflammatory chemokines across clusters. These changes may explain the persistent pulmonary symptoms of cough, sputum production and exertional dyspnea. | |||||||||||||||||||||
493 | Effect of Immunoadsorption on clinical presentation and immune alterations in COVID-19–associated ME/CFS | 2024-09-26 | https://doi.org/10.1101/2024.09.25.24314345 | Moritz Anft | https://www.medrxiv.org/content/10.1101/2024.09.25.24314345v1 | 30 days post-immunoadsorption therapy, patients exhibited notable improvement in neuropsychological function and a substantial amelioration of hand grip strength was observed. However, neither self-reported symptoms nor scores on ME/CSF questionnaires showed a significant improvement and a rebound of the removed proteins occurring within a month. | |||||||||||||||||||||
494 | Sperm quality and sexual function after the first COVID-19 infection during the omicron surge: an observational study in southwest China | 2024-09-26 | doi: 10.21037/tau-24-173 | Tingting Yang | https://tau.amegroups.org/article/view/129262/html | Semen parameters, including total sperm count, total forward sperm, progressive motility, and sperm concentration, significantly declined 45 days after COVID-19 infection. At 90 days after infection, the total sperm count, total forward sperm, and sperm concentration gradually increased to pre-infection levels. 49 (34.3%) of 143 persons confirmed that the COVID-19 infection resulted in changes in sexual function, with an increase in premature ejaculation diagnostic tool (PEDT) scores. | |||||||||||||||||||||
495 | Post-COVID-19 condition in children: epidemiological evidence stratified by acute disease severity | 2024-09-27 | https://doi.org/10.1038/s41390-024-03597-3 | Coen R. Lap | https://www.nature.com/articles/s41390-024-03597-3 | Severe acute COVID-19 in children leads to a higher PPCC prevalence than in mild cases (pediatric Post-COVID-19 condition). At three months, 14.6% of the SARS-CoV-2 positive mild group (RR:6.31 (CI 95%: 2.71–14.67)) and 29.2% of the severe group (RR:12.95 (CI 95%: 5.37–31.23)) reported sequelae, versus 2.3% of the NT (negative COVID test) group. PPCC prevalence in the mild group decreased from 16.1% at one month to 4.4% at one year. | |||||||||||||||||||||
496 | Aggravating mechanisms from COVID-19 | 2024-09-27 | https://doi.org/10.1186/s12985-024-02506-8 | Jong Hoon Lee | https://virologyj.biomedcentral.com/articles/10.1186/s12985-024-02506-8 | The pathophysiology of COVID-19 uses the following three mechanisms: (1) inflammasome activation mechanism; (2) cGAS–STING signaling mechanism; and (3) SAMHD1 tetramerization mechanism, which leads to IFN-I production. Therefore, inflammasome activation, cGAS–STING signaling, and SAMHD1 tetramerization explain acute kidney injury, hepatic, cardiac, neurological, and gastrointestinal injury of COVID-19. | |||||||||||||||||||||
497 | The post-pandemic hospital and mortality burden of COVID-19 compared with influenza: A national cohort study in Denmark, May 2022 to June 2024 | 2024-09-27 | https://doi.org/10.1101/2024.09.26.24314428 | Peter Bager | https://www.medrxiv.org/content/10.1101/2024.09.26.24314428v1 | COVID-19 represented a greater disease burden than influenza, with more hospitalisations and deaths, and more severe disease primarily among non-vaccinated and comorbid patients. Among patients, the risk of mortality of COVID-19 was higher than influenza in the 12-30 days following admission (0-11 days, aHR 1.08, 95%CI 0.94-1.25; 12-30 days, aHR 1.50, 95%CI 1.21-1.84), in particular among non-vaccinated for both COVID-19 and influenza (aHR 1.81, 95%CI 1.25-2.62). | |||||||||||||||||||||
498 | Altered Liver Enzyme Markers in Patients with Asymptomatic, and Mild Omicron Infection: A Retrospective Study | 2024-09-27 | https://doi.org/10.2147/JIR.S478812 | Cao X | https://www.dovepress.com/altered-liver-enzyme-markers-in-patients-with-asymptomatic-and-mild-om-peer-reviewed-fulltext-article-JIR | Our findings suggested that even among asymptomatic or mild patients with Omicron infection, there might be an occurrence of abnormally elevated levels of liver enzyme markers, signifying a certain degree of stress response happening in the liver. Abnormal liver function parameters, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and total bilirubin (TBIL), were observed in 314 (27.71%) patients. | |||||||||||||||||||||
499 | Development of a Risk Predictive Model for Erectile Dysfunction at 12 Months after COVID-19 Recovery: A Prospective Observational Study | 2024-09-27 | https://doi.org/10.3390/jcm13195757 | Fernando Natal Alvarez | https://www.mdpi.com/2077-0383/13/19/5757 | A past history of COVID-19 was shown to be an independent predictor of ED in our sample. The ED prevalence was 55.9% in patients with past history of COVID-19 and 44.1% in those with no past history of COVID-19. | |||||||||||||||||||||
500 | Spectrum of Retinal Microvascular Ischemia in Patients with COVID-19 based on Multimodal Imaging | 2024-09-28 | https://doi.org/10.1016/j.heliyon.2024.e38535 | Min Zhang | https://www.cell.com/heliyon/fulltext/S2405-8440(24)14566-5 | Retinal microvascular ischemia due to COVID-19 infection could be unilateral or bilateral involvement, most shown as multiple lesions. Ocular manifestation of COVID-19 associated microvascular ischemia can be variable, including CWS (cotton wool spot), PAMM (paracentral acute middle maculopathy) and ASHH (Henle fiber layer hyperreflectivity). A total of 32 eyes from 21 patients were included, 24 (75.00%) eyes with multiple retinal whitenings, while 8 (25.00%) eyes with isolated lesions. | |||||||||||||||||||||
501 | The persistence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) after SARS-CoV-2 infection: A systematic review and meta-analysis | 2024-09-29 | https://doi.org/10.1016/j.jinf.2024.106297 | Ankush Dehlia | https://www.sciencedirect.com/science/article/pii/S0163445324002317 | Our study not only demonstrates that LC patients exhibit similar symptom clusters to ME/CFS, but that approximately half of LC patients satisfy a diagnosis of ME/CFS. Our meta-analysis indicated that 51% (95% CI, 42%-60%) of LC patients satisfied ME/CFS diagnostic criteria with fatigue, sleep disruption, and muscle/joint pain being the most common symptoms. Importantly, LC patients also experienced the ME/CFS hallmark symptom, post-exertional malaise. | |||||||||||||||||||||
502 | How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service | 2024-09-29 | https://doi.org/10.3390/jcm13195817 | Rochelle Bodey | https://www.mdpi.com/2077-0383/13/19/5817 | 90.2% patients continued to experience LC symptoms and disability and had not returned to their pre-COVID-19 health status. The average EQ-5D-5L index score was 0.53 (SD 0.29), highlighting a significant disability and that LC had become a long-term condition (LTC) in the majority of patients who responded to the survey. | |||||||||||||||||||||
503 | Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection | 2024-09-30 | https://doi.org/10.1038/s41467-024-52404-4 | Patrick M. Archambault | https://www.nature.com/articles/s41467-024-52404-4#citeas | A high proportion of ED patients reported ongoing PCC symptoms three months after their ED visit, regardless of whether they were infected with SARS-CoV-2 or not. The proportion of patients reporting ongoing symptoms at 6 and 12 months remained high with only a small decrease over time. At three months, test-positive patients reported each individual PCC-consistent symptom at least twice as often as negative patients. | |||||||||||||||||||||
504 | SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production | 2024-09-30 | https://doi.org/10.1128/mbio.02308-24 | Chenyu Zhang | https://pubmed.ncbi.nlm.nih.gov/39345136/ | Our study establishes a direct correlation between the expression of the SARS-CoV-2 viral ORF3a protein and kidney injury induced by ORF3a linking to CAKI (COVID-19-associated kidney injuries). We identified a functional relationship between the expression of the SARS-CoV-2 ORF3a protein and inflammation-driven apoptotic death of renal tubular epithelial cells in patients with CAKI. We demonstrate in vitro that ORF3a independently induces renal cell-specific apoptotic cell death | |||||||||||||||||||||
505 | Long COVID in children and adolescents: a historical cohort study with a population-based control group from Iran | 2024-09-30 | https://doi.org/10.1186/s12879-024-09997-4 | Mohsen Sarani | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09997-4 | 46 individuals of the COVID-19 group (32.6%) manifested long COVID symptoms. The most prevalent symptoms included fatigue (54.3%), impaired attention or concentration (41.3%) and depression or anxiety symptoms (34.7%). Among the hospitalized children experiencing long-term COVID symptoms, 65.2% exhibited moderate disease severity. | |||||||||||||||||||||
506 | Gut colonization of Enterococcus species is associated with COVID-19 disease in Uganda | 2024-09-30 | https://doi.org/10.1101/2024.09.28.24314457 | Carolina Agudelo | https://www.medrxiv.org/content/10.1101/2024.09.28.24314457v1 | Our study finds that the microbiome of COVID-19 individuals is more likely to be disrupted, as indicated by decreased diversity and increased pathobiont levels. Comparison of the COVID-19 patients and their household contacts revealed decreased alpha diversity and blooms of Enterococcus and Eggerthella in COVID-19 cases. | |||||||||||||||||||||
507 | Prevalence, duration, and factors influencing post-COVID conditions among patients at several public hospitals, Alexandria governorate, Egypt 2022–2023 | 2024-09-30 | https://doi.org/10.1016/j.heliyon.2024.e38764 | Rasha Ashmawy | https://www.cell.com/heliyon/fulltext/S2405-8440(24)14795-0 | 760 patients (49.2 %) reported PCC symptoms including, 52.6 % seen at outpatients, 26.7 % were admitted, and 0.5 % required admission to ICU. PCC symptoms included shortness of breath (94.2 %), mood changes (13.9 %), cough (13.0 %), and fatigue (8.8 %). | |||||||||||||||||||||
508 | Associations Between Acute COVID-19 Symptom Profiles and Long COVID Prevalence: Population-Based Cross-Sectional Study | 2024-10-01 | https://doi.org/10.2196/55697 | Jana L Hirschtick | https://publichealth.jmir.org/2024/1/e55697 | In our sample (n=4169), 15.9% (n=693) had long COVID, defined as new or worsening symptoms at least 90 days post SARS-CoV-2 infection. Long COVID prevalence was highest in the multi-symptomatic (39.7%) and predominance of shortness of breath (22.4%) clusters, followed by the flu-like symptom (15.8%), predominance of fatigue (14.5%), fever (6.4%), and nasal congestion (5.6%) clusters. | |||||||||||||||||||||
509 | Impact of SARS-CoV-2 viral load on restrictive spirometry patterns in mild COVID-19 recovered middle-aged individuals: a six-month prospective study | 2024-10-01 | https://doi.org/10.1186/s12879-024-09959-w | Uzair Abbas | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09959-w | We found one third of mild-moderate COVID-19 recovered individuals have restrictive respiratory patterns after 6–8 months of recovery. We observed up to 70% of the participants presented with either shortness of breath (11.5%), body aches (23.5%), recurrent cough (4.4%), recurrent respiratory infections (9.5%) and/or fatigue (33.3%) at follow up. | |||||||||||||||||||||
510 | Long-term COVID-19 sequelae by Theta and SARS-CoV-2 variants in a Philippine cohort | 2024-10-01 | https://doi.org/10.3389/fmed.2024.1455729 | Cynthia P. Saloma | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1455729/full | A large proportion (>68%) of cases in this Philippine cohort previously infected with different SARS-CoV-2 variants presented with long-term complications of COVID-19 characterized by a highly heterogeneous set of debilitating symptoms. General symptoms including headache, fatigue, and post-exertional malaise were the most frequently reported symptoms, while neuropsychiatric symptoms were the second most frequently reported symptoms. | |||||||||||||||||||||
511 | Post COVID-19 syndrome among 5248 healthcare workers in England: longitudinal findings from NHS CHECK | 2024-10-02 | https://doi.org/10.1136/oemed-2024-109621 | Brendan Dempsey | https://pubmed.ncbi.nlm.nih.gov/39358009/ | While a third of HCWs reported prolonged COVID-19 symptoms consistent with PCS (post COVID-19 syndrome), a smaller percentage reported a formal diagnosis of the condition. While 33.6% (n=1730) reported prolonged COVID-19 symptoms consistent with PCS, only 7.4% (n=385) reported a formal diagnosis of PCS. Fatigue, difficult concentrating, insomnia and anxiety or depression were the most common PCS symptoms. | |||||||||||||||||||||
512 | Risk of chronic fatigue syndrome after COVID-19: A retrospective cohort study of 3227281 patients | 2024-10-03 | https://doi.org/10.1016/j.jiph.2024.102559 | Chih-Wei Chen | https://www.sciencedirect.com/science/article/pii/S1876034124002934 | COVID-19 patients have a higher risk of developing CFS (chronic fatique syndrome) compared to individuals without COVID-19. The increased risk is particularly significant in adults aged 18 years and older. The incidence of CFS was higher in the COVID-19 group compared to the non-COVID-19 group at 1 follow-up intervals (HR 1.59, 95% CI = 1.54-1.63). | |||||||||||||||||||||
513 | Understanding long COVID: prevalence, characteristics, and risk factors in the Eastern Province of Saudi Arabia | 2024-10-03 | https://doi.org/10.3389/fmed.2024.1459583 | Adam F. Aldhawyan | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1459583/full | The risk of having a higher symptom count increased by 42.5% 12 months after acute COVID-19 infection compared with baseline (<3 months, p < 0.001). | |||||||||||||||||||||
514 | Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 | 2024-10-04 | https://doi.org/10.1038/s41590-024-01975-x | Joseph I. Bailey | https://www.nature.com/articles/s41590-024-01975-x | Although most patients in our study showed partial resolution of lung fibrosis by CT scan, the transcriptional phenotype of alveolar macrophages was similar in patients who did or did not show resolution. Our analysis indicated that monocyte-derived alveolar macrophages in patients with RPRA who showed improvement continued to express a host of genes that have been causally implicated in lung fibrosis in mouse models. | |||||||||||||||||||||
515 | Emergency department utilization among children with Long COVID symptoms: a COVID-19 research consortium study | 2024-10-05 | https://doi.org/10.1186/s12887-024-04817-9 | Pranav Bhimani | https://pubmed.ncbi.nlm.nih.gov/39369205/ | This study reveals that children with Long COVID symptoms had notably higher odds of ED visits, with chest pain, fluid imbalances, and generalized pain being most closely linked to such visits.Children with Long COVID symptoms/conditions had 152% higher odds (OR: 2.52, CI: 2.32-2.73) of ED visits, while those with specific symptoms including "chest pain" had 255% higher odds (AOR: 3.55, CI: 2.73-4.54) and "fluid and electrolyte disturbances" had 229% higher odds (AOR: 3.29, CI: 2.23-4.73) compared to those without those symptoms/conditions. | |||||||||||||||||||||
516 | The continuous rise in orbital subperiosteal abscess incidence in the Iranian pediatric population | 2024-10-05 | https://doi.org/10.1038/s41598-024-74447-9 | Hassan Asadigandomani | https://www.nature.com/articles/s41598-024-74447-9 | The results of our study revealed an increase of almost 1.5 times (39 compared to 24) in the number of admitted patients diagnosed with orbital SPA in the last autumn and winter. Therefore, it seems that an alarm has been sounded regarding the increase in the incidence of this dangerous complication in the post-COVID era in Iranian children, and the increase in cases reported during the past months is not a coincidence. | |||||||||||||||||||||
517 | Occupational and industry prevalence of new long-term symptoms within American Red Cross blood donors with and without history of SARS-CoV-2 infection | 2024-10-05 | https://doi.org/10.1002/ajim.23670 | Deja L. Edwards | https://onlinelibrary.wiley.com/doi/abs/10.1002/ajim.23670 | New long-term symptoms were more prevalent among those previously infected compared to the never-infected respondents (45% vs 24%, p < 0.05). New long-term neurological and other symptoms were commonly reported by those previously infected with SARS-CoV-2. | |||||||||||||||||||||
518 | SARS-CoV-2 RNAemia as a reliable predictor of long-term mortality among older adults hospitalized in pulmonary intermediate care units: a prospective cohort study | 2024-10-07 | https://doi.org/10.1186/s12985-024-02526-4 | Ying Liang | https://virologyj.biomedcentral.com/articles/10.1186/s12985-024-02526-4 | Patients with SARS-CoV-2 RNAemia were more likely to develop critical cases and had a higher incidence of sepsis. Accordingly, they had a higher 180-day mortality (57.1% vs. 19.7%), as well as in-hospital mortality (50.0% vs. 13.7%), independent of age, disease severity, sepsis, lymphocyte count and C-Reactive protein. In addition, the risk for 180-day mortality increased with the SARS-CoV-2 RNA load in plasma. | |||||||||||||||||||||
519 | Post–COVID-19 Condition Fatigue Outcomes Among Danish Residents | 2024-10-07 | 10.1001/jamanetworkopen.2024.34863 Key Points | Elisabeth O’Regan | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824533 | SARS-CoV-2 infection was associated with a subtle increase in self-reported fatigue and postexertional malaise symptoms 2 to 18 months after mild infection. In contrast, individuals hospitalized with acute SARS-CoV-2 experienced a more substantial increase in postacute symptoms. In the period 2 to 18 months after testing, SARS-CoV-2 infection was associated with a small but significant 3% increase in self-reported fatigue scores and higher odds of self-reported postexertional malaise (odds ratio, 2.04), compared with test-negative participants. | |||||||||||||||||||||
520 | Self-reported Health Service Utilization and Barriers to Care Among US Adults with a History of Post COVID-19 Condition | 2024-10-07 | https://doi.org/10.1007/s11606-024-09079-w | Hiten Naik | https://link.springer.com/article/10.1007/s11606-024-09079-w | Compared to other US adults, participants with a history of PCC (post COVID-19 condition) were more likely to have had an urgent care visit (adjusted odds ratio (aOR) 1.52), emergency room visit (aOR 1.94), hospitalization (aOR 1.48), rehabilitation services (aOR 1.35), home care (aOR 1.55), mental health counseling (aOR 1.39), and complementary and integrative medicine services (aOR 1.29). | |||||||||||||||||||||
521 | Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release | 2024-10-07 | https://doi.org/10.1007/s10495-024-02025-5 | Anna Shteinfer-Kuzmine | https://link.springer.com/article/10.1007/s10495-024-02025-5 | SARS-CoV-2 E-protein induces mitochondrial dysfunction, apoptosis, and mtDNA release via VDAC1 modulation. mtDNA that accumulates in the blood activates the cGAS-STING pathway, triggering inflammatory cytokine and chemokine expression that contribute to the cytokine storm and tissue damage seen in cases of severe COVID-19. | |||||||||||||||||||||
522 | Long COVID at 3 and 6 months after covid-19 infection in Thailand | 2024-10-08 | https://doi.org/10.1038/s41598-024-75233-3 | Sasinuch Rutjanawech | https://www.nature.com/articles/s41598-024-75233-3 | Based on the reported symptoms, long COVID is commonly observed either at 3 or 6 months in our study. Among 1,400 eligible COVID-19 cases, interviews were complete for 1,129 and 932 individuals at 3 and 6 months, respectively. Of those, 431 and 314 reported at least one symptom consistent with long COVID. The point prevalence was 38.2% (95% confidence interval: 35.3–41.1%) and 33.7% (95% confidence interval: 30.7–36.7%) respectively. | |||||||||||||||||||||
523 | Presence of cholestasis and its impact on survival in SARS-CoV-2 associated acute respiratory distress syndrome | 2024-10-08 | https://doi.org/10.1038/s41598-024-73948-x | Mathias Schneeweiss-Gleixner | https://www.nature.com/articles/s41598-024-73948-x | Of 225 included patients 119 (53%) developed cholestasis during ICU stay. Presence of cholestasis and peak ALP levels were independently associated with worse ICU and 6-month survival. | |||||||||||||||||||||
524 | Candidemia Following Severe COVID-19 in Hospitalised and Critical Ill Patients: A Systematic Review and Meta-Analysis | 2024-10-08 | https://doi.org/10.1111/myc.13798 | Karan Srisurapanont | https://onlinelibrary.wiley.com/doi/10.1111/myc.13798 | The global prevalence of CAC (COVID-19-associated candidemia) was 4.33% (95% Cl, 3.16%–5.90%) in intensive care unit (ICU) patients.The mortality rate for CAC was 68.40% (95% Cl, 61.86%–74.28%) among ICU patients. The prevalence of CAC is substantial in the ICU setting, particularly in high-income countries. | |||||||||||||||||||||
525 | Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study | 2024-10-09 | https://doi.org/10.1016/j.cmi.2024.09.001 | Zoe Swan | https://www.sciencedirect.com/science/article/abs/pii/S1198743X24004324 | The findings of this multicohort study indicate that SARS-CoV-2 antigens can be detected in the blood of a substantial proportion of individuals up to 14 months after infection. While approximately one in five asymptomatic individuals was antigen-positive, roughly half of all individuals reporting ongoing cardiopulmonary, musculoskeletal, and neurologic symptoms were antigen-positive. | |||||||||||||||||||||
526 | Post-viral symptoms and conditions are more frequent in COVID-19 than influenza, but not more persistent | 2024-10-09 | https://doi.org/10.1186/s12879-024-10059-y | Falko Tesch | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-10059-y | We found that post-viral symptoms as defined for COVID-19 by the WHO as well as tissue damage were more frequent among the COVID-19 cohort than the influenza or contemporary control cohort. Given the increasingly endemic nature of the disease people will be infected every season, resulting in a constant patient population that needs care. | |||||||||||||||||||||
527 | Longitudinal assessment of health-related quality of life after SARS-CoV-2 infection and the associations with clinical and social characteristics in a general practice population | 2024-10-09 | https://doi.org/10.1186/s12955-024-02301-7 | Rinske van den Hoek | https://hqlo.biomedcentral.com/articles/10.1186/s12955-024-02301-7 | Seventy-six (48.1%) developed PCC, which was associated with a persistent reduction in both physical and mental HRQoL. Hospitalization during the acute phase of the infection had a negative impact on the physical HRQoL, which decreased over time. The negative association PCC has with both mental and physical HRQoL for at least six months, calls for more research to support patients with PCC. | |||||||||||||||||||||
528 | Prevalence and associated risk factors of post-COVID-19 syndrome in healthcare workers | 2024-10-10 | https://doi.org/10.1080/15459624.2024.2406233 | Ana Cláudia Vasconcellos Azeredo | https://www.tandfonline.com/doi/full/10.1080/15459624.2024.2406233?src= | A high prevalence of post-COVID-19 syndrome in HCWs was found. During the study period, 463 HCWs were included in the study, 227 (49.0%) of which experienced post-COVID-19 syndrome. The most common persistent symptoms were fatigue (n = 147 [32.5%]), memory disorders (n = 98 [21.5%]), dyspnea (n = 73 [16.0%]), anxiety/depression (n = 69 [15.0%]), and cough (n = 43 [9.4%]). | |||||||||||||||||||||
529 | Psychiatric outcomes among COVID-19 egyptian patients at ain shams university quarantine hospitals: A cross-sectional study | 2024-10-10 | https://doi.org/10.1186/s41983-024-00896-8 | Fairouz Tawfik | https://link.springer.com/article/10.1186/s41983-024-00896-8 | A significant portion of the study’s patients experienced psychiatric consequences following COVID-19 infection, with 79.29% developing PTSD, 61.43% suffering from depression, and 18.57% experiencing anxiety. The severity of COVID-19 infection was significantly associated with PTSD severity mean scores (P value = 0.027). Furthermore, a significant relationship was observed between the severity of depression and COVID-19 infection severity (P value = 0.028). | |||||||||||||||||||||
530 | Analysis of fat oxidation capacity during cardiopulmonary exercise testing indicates long-lasting metabolic disturbance in patients with post-covid-19 syndrome | 2024-10-10 | https://doi.org/10.1016/j.clnu.2024.10.010 | René Garbsch | https://www.clinicalnutritionjournal.com/article/S0261-5614(24)00368-6/fulltext | PCS-specific restrictions in fat oxidation may indicate persistent mitochondrial dysfunction. Fat oxidation capacity was disturbed in PCS patients overall (AUC: 11.3 [10.7–11.9]) compared to healthy controls (p < 0.0001), with hospitalization during acute infection predicting the level of disturbance (p < 0.0001). | |||||||||||||||||||||
531 | Comparison of clinical and laboratory characteristics of COVID-19 and influenza in hospitalized children | 2024-10-11 | https://doi.org/10.1007/s10096-024-04964-y | Zeynep Savaş Şen | https://link.springer.com/article/10.1007/s10096-024-04964-y | PICU admission rates and oxygen support needs were similar in both groups. When the virus was COVID-19, it had 7.8 times higher risk of mortality compared to influenza. There were statistically significant risk for mortality when the virus was COVID-19, the risk of mortality was 6.9 times higher in those with UCD (Underlying chronic disease), 8.5 times higher in those with admission to PICU and 3.8 times higher in those with needing mechanical ventilation compared to when the virus was influenza. | |||||||||||||||||||||
532 | SARS-CoV-2 Infection and New-Onset Type 2 Diabetes Among Pediatric Patients, 2020 to 2022 | 2024-10-14 | doi:10.1001/jamanetworkopen.2024.39444 | Margaret G. Miller | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824731 | In this retrospective cohort study of children and adolescents aged 10 to 19 years, the risk of an incident diagnosis of T2D was greater following a COVID-19 diagnosis than in children diagnosed with ORIs (other Respiratory Infections). Risk of a new diagnosis of T2D was significantly increased from day of infection to 1, 3, and 6 months after COVID-19 diagnosis compared with the matched cohort with ORIs (RR at 1 month, 1.55; RR at 3 months: 1.48; RR at 6 months: 1.58.) | |||||||||||||||||||||
533 | The short-term and long-term prognosis of discharged COVID-19 patients in Guangdong during the first wave of pandemic | 2024-10-14 | https://doi.org/10.1038/s41598-024-76013-9 | Pei-hong Li | https://www.nature.com/articles/s41598-024-76013-9 | Compared to the early stage (2 to 12 weeks with late-stage being 24 to 48 weeks), the proportions of patients with depression (early stage 14.6%, late stage 4.6%), anxiety (early stage 8.9%, late stage 5.3%), PTSD(early stage 3.6%, late stage 0.7%), abnormal liver function (early stage 24.6%, late stage 11.0%), abnormal cardiac function (early stage 10.0%, late stage 7.8%), abnormal renal function (early stage 20.6%, late stage 11.0%) and abnormal pulmonary function (early stage 40.9%, late stage 13.5%) were significantly reduced in the late stage. | |||||||||||||||||||||
534 | Long-Term Impacts of COVID-19 on Thyroid Health: Insights From Clinical Studies | 2024-10-14 | 10.7759/cureus.71469 | Ria Syal | https://www.cureus.com/articles/293821-long-term-impacts-of-covid-19-on-thyroid-health-insights-from-clinical-studies#!/ | COVID-19 affects the thyroid gland multifacetedly and includes direct viral invasion, immune-mediated damage, and hypothalamic-pituitary-thyroid axis disruption. Long-term effects, including those observed in children, include persistent hypothyroidism and exacerbated pre-existing thyroid-autoimmune conditions. | |||||||||||||||||||||
535 | The impact of mild COVID‐19 on medium‐term respiratory function | 2024-10-14 | https://doi.org/10.7196/AJTCCM.2024.v30i3.1629 | J van Heerden | https://samajournals.co.za/index.php/ajtccm/article/view/1629 | DLCO (diffusing capacity of the lungs for carbon monoxide) was low in a considerable proportion of non‐healthcare‐seeking individuals 2 years after mild COVID‐19. Lower than expected DLCO was the most commonly detected abnormality (57%). Spirometry anomalies were noted in 23%, 10% showing an obstructive impairment and 13% a restrictive impairment, confirmed by a total lung capacity <80%. | |||||||||||||||||||||
536 | Effect of Long COVID on Work Performance and Annual Monetary Loss among Infected Healthcare Workers at a Tertiary Hospital in Malaysia | 2024-10-15 | DOI: 10.1097/JOM.0000000000003256 | Lim, Say Hiang | https://journals.lww.com/joem/abstract/9900/effect_of_long_covid_on_work_performance_and.682.aspx | Healthcare workers with Long COVID have a significantly lower absolute presenteeism and higher annual monetary loss of presenteeism. The mean annual monetary loss of presenteeism was higher in those with Long COVID (MYR 10,866.61) compared to those without (MYR 9,243.85). | |||||||||||||||||||||
537 | Chronic Symptomatology Among Infants, Children, and Adolescents Within 12 Months After SARS-CoV-2 Infection | 2024-10-16 | https://doi.org/10.1177/2333794X241287096 | Jennifer S. Read | https://journals.sagepub.com/doi/10.1177/2333794X241287096 | Of 212 infants, children, and adolescents, 11 (5.2%) experienced a wide range of mild to severe chronic symptoms following SARS-CoV-2 infection, with 90% indicating inability to continue normal activities. Of those reporting chronic symptoms, most indicated the onset at or before 3 months following the acute SARS-CoV-2 infection. | |||||||||||||||||||||
538 | Sex, vaccination status, and comorbidities influence long COVID persistence | 2024-10-17 | https://doi.org/10.1016/j.jiph.2024.102562 | Trevon Fuller | https://www.sciencedirect.com/science/article/pii/S187603412400296X | In this population, symptom persistence declined after the acute phase, but 5 % of participants did not fully recover. Long COVID persisted for ≥ two months in 21 % and ≥ 12 months in 5 %. The most common symptoms were fatigue, upper respiratory symptoms, and myalgia/arthralgia: 15 % had fatigue for ≥ one month, 10 % for ≥ two months, and 5 % ≥ three months. | |||||||||||||||||||||
539 | Impact of post-COVID symptoms on activity and participation of women and men | 2024-10-17 | https://doi.org/10.1038/s41598-024-74568-1 | Jana Rosenstein | https://www.nature.com/articles/s41598-024-74568-1 | This study found that study participants with post-COVID symptoms also experience ALPR (activity limitations and participation restrictions). Moreover, we noticed frequent correlations between fatigue, as one of the most common health problems, and several ALPR. | |||||||||||||||||||||
540 | Prevalence and exploratory factor analysis of long COVID-19 symptoms among experienced infected population in Bangkok, Thailand | 2024-10-17 | https://doi.org/10.1186/s12889-024-20275-5 | Suphanna Krongthaeo | https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-20275-5 | The prevalence of long COVID was 32.9%. The main reported symptoms included anxiety (28.5%), fatigue (26.1%), and dyspnea (13.4%). There was a significant relationship between symptom severity and functional disability (rs=0.385, p value < 0.01). Overall health was negatively correlated with symptom severity (rs = − 0.291, p < .01) and functional disability (rs = − 0.108, p < .05). | |||||||||||||||||||||
541 | Evaluating the risk of sleep disorders in subjects with a prior COVID-19 infection | 2024-10-17 | https://doi.org/10.1371/journal.pone.0311929 | Jaewhan Kim | https://pubmed.ncbi.nlm.nih.gov/39418274/ | Those who had a COVID-19 infection in 2020 were 53% more likely to have a sleep disorder in 2021 (OR = 1.53; 95% Confidence Interval: 1.48-1.58). | |||||||||||||||||||||
542 | Prevalence, Risk Factors, and Impact of Long COVID Among Adults in South Korea | 2024-10-17 | https://doi.org/10.3390/healthcare12202062 | Ha-Eun Son | https://www.mdpi.com/2227-9032/12/20/2062 | Long COVID, as defined by the WHO criteria, had a prevalence of 19.7-24.9% in females and 12.7% in males. Among those with long COVID, 54.2% experienced daily activity limitations, and 40.6% received treatment. | |||||||||||||||||||||
543 | Long-term effects of COVID-19 infection on bone mineral density | 2024-10-18 | DOI: 10.7189/jogh.14.05029 | Zhan Wang | https://jogh.org/2024/jogh-14-05029 | This study provided evidence for the COVID-19 process to bone health. We successfully identified three latent BMD (bone mineral density) trajectories to reveal the dynamic effects of COVID-19 infection on bone health in patients, namely, the early low-normal decline group, the average, and the early high-rapid decline group. All groups demonstrated consistent overall declining trends. | |||||||||||||||||||||
544 | One-year trajectories of physical and mental health-related quality of life, fatigue and dyspnoea in COVID-19 survivors | 2024-10-19 | https://doi.org/10.1007/s11136-024-03812-y | Gerko Schaap | https://link.springer.com/article/10.1007/s11136-024-03812-y | A substantial number of COVID-19 survivors continue to struggle with reduced HRQoL (health-related quality of life ) over time. Three trajectories (‘stable high’ (16%), ‘improving’ (40%), and ‘stable low’ (44%)) were found for physical HRQoL, and four (‘stable high’ (43%), ‘improving’ (14%), ‘middle declining’ (17%), and ‘low’ (26%)) for mental HRQoL. | |||||||||||||||||||||
545 | Characterization of Change in Cognition Before and After COVID-19 Infection in Essential Workers at Midlife | 2024-10-19 | https://doi.org/10.1016/j.ajmo.2024.100076 | Zennur Sekendiz | https://www.sciencedirect.com/science/article/pii/S266703642400013X | Findings from this longitudinal causal modeling study revealed that COVID-19 and PASC appeared to cause clincially relevant cognitive deterioration. Longitudinal models indicated a significant decline in cognitive throughput (β = -0.168, P = .001) following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors. Associations were larger in those with more severe COVID-19 and those who reported PASC. Observed changes in throughput were equivalent to 10.6 years of normal aging. | |||||||||||||||||||||
546 | Increased post-COVID-19 behavioral, emotional, and social problems in Taiwanese children | 2024-10-20 | https://doi.org/10.1016/j.jfma.2024.10.018 | Chi-Yung Shang | https://www.sciencedirect.com/science/article/pii/S0929664624004947 | Compared with the control group, the COVID group in the post-COVID condition had more severe symptoms of inattention, hyperactivity-impulsivity, opposition, a wide range of emotional and behavioral problems, and poor school functions, school attitude, social interaction, school behavioral problems, and interaction problems with their parents. Compared with the pre-COVID condition, the COVID group had greater severity of inattention, somatic complaints, thought problems, internalizing problems, poor school functions, and interaction problems with their parents in the post-COVID condition. | |||||||||||||||||||||
547 | Long Covid: a global health issue – a prospective, cohort study set in four continents | 2024-10-21 | https://doi.org/10.1136/bmjgh-2024-015245 | Ekaterina Pazukhina | https://gh.bmj.com/content/9/10/e015245 | Of the participants, 37.0% (2400/6402) reported not feeling fully recovered at 2 to <6 months and 46.5% (2863/6152) at 6 to <12 months postdischarge. Our data show that Long Covid affects populations globally, manifesting similar symptomatology and impact on functioning in both HIC (high-income countries) and LMICs (low-income and middle-income countries). The prevalence was higher in HICs versus LMICs. | |||||||||||||||||||||
548 | Persistence of dysfunctional immune response 12 months after SARS-CoV-2 infection and their relationship with pulmonary sequelae and long covid | 2024-10-21 | https://doi.org/10.21203/rs.3.rs-5019121/v1 | Tamara Cruz | https://www.researchsquare.com/article/rs-5019121/v1 | Patients with PS (pulmonary sequelae) or LC (long COVID) have abnormal but different persistent circulatory immune and organ damage biomarkers, suggesting different underlying biology of both post-COVID conditions. Patients with PS showed higher levels of anti-nuclear autoantibodies, whereas LC patients had increased levels of organ-damage associated proteins. | |||||||||||||||||||||
549 | One-year mortality and associated factors in older hospitalized COVID-19 survivors: a Nationwide Cohort Study in Korea | 2024-10-22 | https://doi.org/10.1038/s41598-024-76871-3 | Eunji Kim | https://www.nature.com/articles/s41598-024-76871-3 | Among the 66,810 COVID-19 patients aged 60 years or older who were hospitalized during the study period, the in-hospital mortality rate was 4.8% (n = 3219). Among the survivors (n = 63,369), the 1-year mortality rate was 4.9% (n = 3093). Multivariable logistic regression analysis identified older age, male sex, cardiovascular disease, immunosuppression, organ dysfunction, illness severity, and corticosteroid use during hospitalization as factors associated with death within 1 year after hospital discharge. | |||||||||||||||||||||
550 | Associations between symptom-based long COVID clusters and long-term quality of life, work and daily activities among individuals testing positive for SARS-CoV-2 at a national retail pharmacy | 2024-10-22 | https://doi.org/10.1186/s41687-024-00797-7 | Manuela Di Fusco | https://jpro.springeropen.com/articles/10.1186/s41687-024-00797-7 | The study included 328 participants that were segmented into three groups of long COVID-19 symptoms based on LCA and then simplified by the number of symptoms (Cluster 1 low, <2; Cluster 2 moderate, 2–6; and Cluster 3 high, >6 symptoms). There were 48.8%, 33.2% and 18.0% of participants, respectively, in Cluster 1, Cluster 2, and Cluster 3. The number of long COVID-19 symptoms was negatively associated with HRQoL and WPAI (Work Productivity and Activity Impairment), whereby participants with high symptom burden (>6 symptoms) had the lowest HRQoL and WPAI scores assessed by absenteeism, presenteeism, work productivity loss, activity impairment, and hours worked metrics. | |||||||||||||||||||||
551 | Prevalence and associations of insomnia after COVID-19 infection | 2024-10-22 | https://doi.org/10.5664/jcsm.11420 | Alexandra Kadl | https://pubmed.ncbi.nlm.nih.gov/39436395/ | Initial and persistent insomnia is common in long COVID. The prevalence of significant insomnia at the initial visit was 50% and 42% at the subsequent visit (obtained in 78 of the 280 patients). | |||||||||||||||||||||
552 | Elevated Liver Damage Biomarkers in Long COVID: A Systematic Review and Meta-Analysis | 2024-10-22 | https://doi.org/10.1101/2024.10.18.24315698 | Abbas F. Almulla | https://www.medrxiv.org/content/10.1101/2024.10.18.24315698v1 | This study suggests that LC is associated with persistent liver damage and coagulopathy,highlighting the need to incorporate liver injury into treatment strategies to reduce potential risks. Our analysis identified a significant increase in the liver damage index among LC patients,with a moderate effect size (standardized mean difference,SMD = 0.553;confidence intervals; 95% CI: 0.305;0.760) compared to normal controls. | |||||||||||||||||||||
553 | Clinical features and predictive nomogram for fatigue sequelae in non-severe patients infected with SARS-CoV-2 Omicron variant in Shanghai, China | 2024-10-22 | https://doi.org/10.1016/j.bbih.2024.100889 | Xiao-Lei Shen | https://www.sciencedirect.com/science/article/pii/S2666354624001674 | Nearly half of the patients infected with COVID-19 Omicron variant complained of sequelae, and fatigue was the most common symptom, which was correlated with depression. A total of 108 (48.4%) of the 223 non-severe COVID-19 patients reported sequelae for more than 4 weeks, and of these, 35 (15.7%) had fatigue sequelae that were scale-confirmed. Other sequelae of more than 10% were brain fog (n = 37,16.6%), cough (n = 26,11.7%) and insomnia (n = 23,10.3%). | |||||||||||||||||||||
554 | Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel study | 2024-10-23 | https://doi.org/10.1016/j.lana.2024.100909 | Chad K. Porter | https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00236-9/fulltext | In this population of healthy young adult US Marines with mostly either asymptomatic or mild acute COVID-19, one fourth reported physical, cognitive, or psychiatric long-term sequelae of infection. The Marines affected with PASC showed evidence of long-term decrease in functional performance suggesting that SARS-CoV-2 infection may negatively affect health for a significant proportion of young adults. | |||||||||||||||||||||
555 | Mexican Hispanics show significant improvement in lung function approximately 1 year after having severe COVID-19 | 2024-10-24 | https://doi.org/10.1113/ep091934 | Arturo Cortes-Telles | https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP091934 | Initially, 61% of patients exhibited at least one of several pulmonary function abnormalities (lower limit of normal = -1.645), which decreased to 22% of patients by 390 days post-recovery. Considering day-to-day variability in lung function, 68% of patients showed improvement by the final visit, while 30% had unchanged lung function from the initial assessment. | |||||||||||||||||||||
556 | Overlapping conditions in Long COVID at a multisite academic center | 2024-10-24 | https://doi.org/10.3389/fneur.2024.1482917 | Stephanie L. Grach | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1482917/full | The greatest prevalence of new or worsening comorbidities following SARS-CoV-2 infection in patients with LC vs. controls reported in this study were pain (94.4% vs. 0%, p < 0.001), neurological (92.4% vs. 15.4%, p < 0.001), sleep (82.8% vs. 5.3%, p < 0.001), skin (69.8% vs. 0%, p < 0.001), and genitourinary (60.6% vs. 25.0%, p = 0.029) issues. 58% of LC patients screened positive for ME/CFS vs. 0% of controls (p < 0.001), 27% positive for GJH (generalized joint hypermobility) compared to 10% of controls (p = 0.026), and a positive average score of 4.0 on orthostatic intolerance vs. 0 (p < 0.001). | |||||||||||||||||||||
557 | Pain among US adults before, during, and after the COVID-19 pandemic | 2024-10-25 | https://doi.org/10.1101/2024.10.24.24316018 | Anna Zajacova | https://www.medrxiv.org/content/10.1101/2024.10.24.24316018v1 | Our results indicate that adults with long COVID are indeed significantly more likely to report both chronic and high-impact pain. Chronic pain prevalence was 20.6% (19.9-21.2%) in 2019, 20.9% (20.3-21.6%) in 2021, and 24.3% (23.7-25.0%) in 2023. HICP (High-Impact Chronic Pain) also increased from 7.5% (7.1-7.8%) in 2019, to 8.5% (8.1-8.9%) in 2023. COVID and long COVID had a modest role in the population-wide pain increases. | |||||||||||||||||||||
558 | Hospitalization for COVID-19, Other Respiratory Infections, and Postacute Patient-Reported Symptoms | 2024-10-25 | doi:10.1001/jamanetworkopen.2024.41615 | Yaqing Gao | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825348 | PAIS (postacute infection syndrome) is not unique to COVID-19; it can also occur in people with other severe LRTIs. However, compared with other LRTIs, COVID-19 appeared to impose an extra burden of neurological, cognitive, and fatigue symptoms. Compared with the reference group, COVID-19 hospitalization was associated with higher risks of 23 of 45 symptoms. COVID-19 hospitalizations were associated with an increased risk of 7 individual symptoms: anosmia (OR, 1.80), ageusia (OR, 1.52), postural tachycardia (OR, 1.60), problem of thinking (OR, 1.36), bone pain (OR, 1.33), mild fatigue (OR, 1.19), and severe fatigue (OR, 1.49). | |||||||||||||||||||||
559 | Clinical aspects, persistent symptoms, physical functionality, and quality of life 24 months after COVID-19 | 2024-10-25 | https://doi.org/10.21203/rs.3.rs-5242403/v1 | Marcos Moreno Salgado | https://www.researchsquare.com/article/rs-5242403/v1 | Moderate functional limitation was reported by 51.2%, and 48% experienced fatigue. Symptoms as fatigue, joint pain, and dyspnea, persisted approximately 24 months post-COVID-19. | |||||||||||||||||||||
560 | Prevalence and measurement of post-exertional malaise in post-acute COVID-19 syndrome: A systematic review and meta-analysis | 2024-10-26 | https://doi.org/10.1016/j.genhosppsych.2024.10.011 | Yi An | https://www.sciencedirect.com/science/article/pii/S0163834324002160 | The pooled prevalence of PEM (post-exertional malaise) among PACS patients at 3 months or more after COVID-19 diagnosis was 0.55 (95 % CI, 0.38, 0.71). | |||||||||||||||||||||
561 | Using General Practice Patient Survey data to explore prevalence and patient uncertainty about Long Covid | 2024-10-27 | https://doi.org/10.1101/2024.10.25.24316047 | Mirembe Woodrow | https://www.medrxiv.org/content/10.1101/2024.10.25.24316047v1 | 4.8% of respondents reported having LC, and 9.1% were unsure. There is an unequal distribution of LC in England, with the condition being more prevalent in minoritised and disadvantaged groups. There are also high levels of uncertainty about having LC. | |||||||||||||||||||||
562 | Persistent pulmonary impairment after 2 years of COVID-19 infection: An observational study | 2024-10-29 | https://doi.org/10.4103/lungindia.lungindia_87_24 | Tejas Menon Suri | https://pubmed.ncbi.nlm.nih.gov/39465918/ | Persistent self-reported dyspnoea and impaired pulmonary functions were common in COVID-19 survivors beyond 2 years of infection. Between T1 (1.9-5.5 months) and T2 (27.2 -32.2 months), the prevalence of self-reported dyspnoea remained stable in the whole cohort (39.4% vs. 36.4%, P = 0.26) but declined in the sub-group with moderate-to-severe COVID-19 (63% vs. 54.6%, P = 0.03). | |||||||||||||||||||||
563 | Evaluating the Predictors of Persistent Long COVID Symptoms and Their Severity in COVID-19 Survivors 1 Year After Infection | 2024-10-29 | https://doi.org/10.1177/21501319241295686 | Adam F. Aldhawyan | https://journals.sagepub.com/doi/10.1177/21501319241295686 | The present study revealed a positive association between the number of acute-phase symptoms and the probability of LC symptoms after 12 months. W Cough and exertional dyspnea were the most common symptoms observed in 16.9% and 8.6% of participants, respectively. The prevalence of LC memory impairment in our sample was 13.2%. | |||||||||||||||||||||
564 | Long-term Impacts of Long COVID: Increased Incidence of Cardiomyopathies, Joint Diseases, and Psychoanxiety Disorders | 2024-10-29 | https://doi.org/10.21873/invivo.13786 | ANDRADA FLORINA MOLDOVAN | https://iv.iiarjournals.org/content/38/6/3022 | Long-COVID was also linked to higher occurrences of diabetes and gastrointestinal diseases. Joint diseases rose by 14%, indicating persistent inflammation. Cardiomyopathies increased by 3.9%, predominantly in high-risk groups, and psychoanxiety disorders surged by 39.5%. | |||||||||||||||||||||
565 | Early pulmonary fibrosis-like changes between delta and pre-delta periods in patients with severe COVID-19 pneumonia on mechanical ventilation | 2024-10-30 | https://doi.org/10.1038/s41598-024-77405-7 | Jung-Wan Yoo | https://www.nature.com/articles/s41598-024-77405-7 | Fibrosis-like changes on chest CT (median 51 days from enrollment to follow up CT scan) were identified in 75.3%. Delta group showed more fibrosis-like changes (≥ 2) (69.8% vs. 43.1%) and more frequent reticulation and architectural distortion+/-parenchymal band than pre-delta group. | |||||||||||||||||||||
566 | Bone Mineral Density, Bone Biomarkers, and Joints in Acute, Post, and Long COVID-19: A Systematic Review | 2024-10-30 | https://doi.org/10.3390/v16111694 | Fahad Alghamdi | https://www.mdpi.com/1999-4915/16/11/1694 | Five studies involving 305 out of 495 infected individuals observed a reduced BMD ()Bone Mineral Densiity after COVID-19, with the most significant reduction occurring a year later. Both bone resorption and bone formation markers decreased, while regulatory markers showed higher levels in infected patients. COVID-19 may harm bone health by increasing bone regulatory markers and reducing bone formation and absorption, leading to a lower BMD. | |||||||||||||||||||||
567 | Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data | 2024-10-30 | https://doi.org/10.1016/j.eclinm.2024.102903 | Junqing Xie | https://www.sciencedirect.com/science/article/pii/S2589537024004826 | The 1-year IR of any post-acute COVID-19 symptom in the COVID-19 infection cohort varied significantly across databases, from 4.4 per 100 person-years to 103.9. The five most common symptoms were joint pain (from 1.6 to 14.3), abdominal pain (from 0.3 to 9.9), gastrointestinal issues (from 0.6 to 13.3), cough (from 0.3 to 9.1), and anxiety (from 0.8 to 11.4). | |||||||||||||||||||||
568 | Longitudinal Fecal Microbiota Profiles in A Cohort of Non-Hospitalized Adolescents and Young Adults with COVID-19: Associations with SARS-CoV-2 Status and Long-Term Fatigue | 2024-10-31 | https://doi.org/10.3390/pathogens13110953 | Christine Olbjørn | https://www.mdpi.com/2076-0817/13/11/953 | The abundance of both known (Faecalibacterium prausnitzii, Streptococcus thermophilus) and new (Clostridium spiroforme, Sutterella wadsworthensis) bacteria were associated with persistent symptoms such as fatigue in the COVID-19 infected group. In the SARS-CoV-2 positive group, lower baseline levels of F. prausnitzii M21/2 and R. bicirculans and a higher abundance of C. spiroforme, S. wadsworthensis, and S. thermophilus were associated with fatigue at six months. | |||||||||||||||||||||
569 | Factors associated with the development, severity, and resolution of post COVID-19 condition in adults living in Canada, January 2020 to August 2022 | 2024-11-01 | https://doi.org/10.17269/s41997-024-00958-7 | Dianne Zakaria | https://link.springer.com/article/10.17269/s41997-024-00958-7 | 17.2% (95% CI 15.7, 18.8) of adults with confirmed infections and 16.7% (95% CI 15.5, 18.0) of adults with confirmed or suspected infections experienced PCC. Two or more pre-existing chronic conditions (aHRs from 0.33 to 0.38), or PCC symptoms relating to the heart (aHR = 0.25, 95% CI 0.07, 0.90), brain fog (aHR = 0.44, 95% CI 0.23, 0.86), or stress/anxiety (aHR = 0.48, 95% CI 0.24, 0.96) were associated with a decreased rate of symptom resolution. | |||||||||||||||||||||
570 | Long-term course and factors influencing work ability and return to work in post-COVID patients 12 months after inpatient rehabilitation | 2024-11-01 | https://doi.org/10.1186/s12995-024-00443-4 | Katrin Müller | https://link.springer.com/article/10.1186/s12995-024-00443-4 | At T4 (12 months after rehabilitation), the median of WAI (Work Ability Index) total score indicated poor work ability, which significantly worsened over time. A total of 48.6% of patients had returned to work 12 months after rehabilitation. Fatigue was identified as the main predictor of reduced work ability and RTW (return to work). | |||||||||||||||||||||
571 | Monitoring of lung stiffness for long-COVID patients using magnetic resonance elastography (MRE) | 2024-11-02 | https://doi.org/10.1016/j.mri.2024.110269 | Sabine F. Bensamoun | https://www.sciencedirect.com/science/article/abs/pii/S0730725X24002509 | The density for long-COVID patients was significantly (P = 0.047) greater (170 kg.m−3) compared to healthy (125 kg.m−3) subjects. After the first MRE test, the stiffness measured for the healthy subjects was in the same range (median value (interquartile range, IQR): 0.93 (0.09) kPa), while the long-COVID patients showed a larger stiffness range (from 1.39 kPa to 2.05 kPa). After a minimum delay of 5 months, the second MRE test showed a decrease of stiffness (from 22 % to 40 %) for every long-COVID patient. | |||||||||||||||||||||
572 | Persistent symptoms after COVID-19: an Australian stratified random health survey on long COVID | 2024-11-03 | https://doi.org/10.5694/mja2.52473 | Alex Holmes | https://onlinelibrary.wiley.com/doi/10.5694/mja2.52473 | Persistent symptoms after COVID-19 are common, though with a lower incidence following infection from less virulent strains. A total of 1656 respondents (14.2%; 95% CI, 13.4–15.0%) were classified as having clinical long COVID using the criteria of at least one persistent new symptom and less than 80% recovery three months after the infection. Of the respondents with clinical long COVID, 535 (3.2%; 95% CI, 2.6–3.8%) reported at least moderate problems with usual activities at 12 months after their infection. | |||||||||||||||||||||
573 | Presence of COVID-19 self-reported symptoms at 12 months in patients discharged from hospital in 2020–2021: a Spanish cross-sectional study | 2024-11-04 | https://doi.org/10.1038/s41598-024-78017-x | Ignacio Pérez Catalán | https://www.nature.com/articles/s41598-024-78017-x | Patients admitted for SARS-CoV-2 infection frequently experience symptoms at one year, especially neurological and respiratory symptoms. The most frequent symptom groups were neurological (n = 225; 46.3%) and respiratory (n = 201; 41.4%). | |||||||||||||||||||||
574 | Novel biomarkers of mitochondrial dysfunction in Long COVID patients | 2024-11-04 | https://doi.org/10.1007/s11357-024-01398-4 | Titanilla Szögi | https://link.springer.com/article/10.1007/s11357-024-01398-4 | We noted increased levels of superoxide dismutase 1 which signals oxidative stress and elevated autophagy-related 4B cysteine peptidase levels, indicating disruptions in mitophagy. Importantly, our analysis also identified reduced levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in these patients, serving as a novel biomarker for the condition. These findings underscore the crucial role of persistent mitochondrial dysfunction in the pathogenesis of Long COVID. | |||||||||||||||||||||
575 | Long COVID and recovery from Long COVID: quality of life impairments and subjective cognitive decline at a median of 2 years after initial infection | 2024-11-05 | https://doi.org/10.1186/s12879-024-10158-w | Warren Szewczyk | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-10158-w | Long COVID is associated with long-term subjective cognitive decline and diminished quality of life. Clinically significant cognitive complaints, fatigue, and pain were present even in those who reported they had recovered from Long COVID. A significantly greater proportion of the Long COVID (n = 215) group, (Current and Recovered combined), had moderate-to-severe impairment in all health domains assessed compared to those Without Long COVID (n = 220; all p < 0.05). The Recovered Long COVID group (n = 34) had significantly lower prevalence of fatigue, pain, depression, and physical and social function impairment compared to those with Current Long COVID (n = 181; all p < 0.05). However, compared to patients Without Long COVID, the Recovered Long COVID group had greater prevalences of fatigue, pain (p ≤ 0.06) and subjective cognitive decline (61.8% vs 29.1%; p < 0.01). | |||||||||||||||||||||
576 | Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study | 2024-11-05 | https://doi.org/10.1038/s41598-024-74404-6 | Dana Yelin | https://www.nature.com/articles/s41598-024-74404-6 | In this report of 458 individuals with long COVID (diffusing capacity for carbon monoxide) recovering from mild to moderate illness, the proportion of impaired DLCO was 17%. In conclusion, impaired DLCO is not uncommon among long COVID patients recovering from mild acute infection. | |||||||||||||||||||||
577 | Stroop task and practice effects demonstrate cognitive dysfunction in long COVID and myalgic encephalomyelitis / chronic fatigue syndrome | 2024-11-05 | https://doi.org/10.1038/s41598-024-75651-3 | James N Baraniuk | https://www.nature.com/articles/s41598-024-75651-3 | Cognitive dysfunction in Long COVID and ME/CFS was demonstrated using the Stroop task which found global slowing of response times and limitations of practice effects. LC and ME/CFS have global slowing of response times that cannot be overcome by practice suggesting impaired communications between network nodes during problem solving. | |||||||||||||||||||||
578 | Prevalence of chronic fatigue syndrome and its related factors in covid- 19 patients discharged from at northwest of Iran hospitals in 2022 | 2024-11-05 | https://doi.org/10.21203/rs.3.rs-5305350/v1 | Arman Alizadeh | https://www.researchsquare.com/article/rs-5305350/v1 | Post-COVID-19 fatigue is a major issue following the initial acute illness with COVID-19, with a prevalence of %12.64. The findings showed that the prevalence of chronic fatigue with history of previous disease (P = 0.04), history of drug use (P = 0.01), history of smoking (P = 0.04), history of mechanical ventilation (P = 0.05) and age (P = 0.001) has a significant relationship. | |||||||||||||||||||||
579 | Factors influencing the course of post-COVID-19-related symptoms: A bidirectional cohort study among employees in health and welfare services in Germany | 2024-11-05 | https://dx.doi.org/10.3205/dgkh000516 | Lara Steinke | https://www.egms.de/static/en/journals/dgkh/2024-19/dgkh000516.shtml | More than a year after a COVID-19 illness, two-thirds of the healthcare staff surveyed reported persistent symptoms. The most common persistent symptoms at all three survey time points were fatigue, concentration and memory problems, and dyspnea. After three months, 76.2% (95% CI: 74.2-78.2%) of participants still reported symptoms, after 18 months this dropped to 67.2% (95% CI: 65.0-69.4%). | |||||||||||||||||||||
580 | Persistent Health and Cognitive Impairments Up to Four Years Post-COVID-19 in Young Students: The Impact of Virus Variants and Vaccination Timing | 2024-11-06 | https://doi.org/10.1101/2024.11.06.24316832 | Ashkan Latifi | https://www.medrxiv.org/content/10.1101/2024.11.06.24316832v1 | Our results show that some health and cognitive impairments persist, with some even progressively worsening especially fatigue in women and memory in men, up to four years post-infection, with the Wuhan variant having the most significant long-term impact and the Omicron variant the least.It also showed that even among young individuals, who mostly experienced relatively mild cases of COVID-19, some symptoms (such as frequent fatigue, impaired memory, and certain health issues) can persist for up to four years | |||||||||||||||||||||
581 | Clinical and Epidemiological Features of Pediatric COVID-19: A Retrospective Study | 2024-11-06 | https://doi.org/10.1002/hsr2.70181 | Mohammadreza Mirkarimi | https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70181 | The outcomes of this study revealed a significantly higher prevalence of malnutrition, anemia, vitamin D insufficiency or deficiency, elevated liver and kidney function test results, and increased inflammatory markers in children with moderate to severe COVID-19 compared to those with mild COVID-19. Patients with severe or moderate COVID-19 had substantially higher levels of various inflammatory markers... compared to children with mild COVID-19 (p < 0.001); they also had lower levels of lymphocytes, hemoglobin (Hb), and vitamin D than patients with mild COVID-19 (p < 0.001). | |||||||||||||||||||||
582 | Predicting post-COVID-19 condition in children and young people up to 24 months after a positive SARS-CoV-2 PCR-test: the CLoCk study | 2024-11-07 | https://doi.org/10.1186/s12916-024-03708-1 | Manjula D. Nugawela | https://link.springer.com/article/10.1186/s12916-024-03708-1 | While 24.7% (233/943) of CYP (children and young people) met the PCC definition 3 months post-infection, only 7.2% (68/943) continued to meet the PCC definition at all three subsequent timepoints, i.e. at 6, 12 and 24 months. | |||||||||||||||||||||
583 | A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome | 2024-11-08 | https://doi.org/10.1038/s41598-024-76827-7 | Moritz Güttes | https://www.nature.com/articles/s41598-024-76827-7 | The PCS patients performed significantly worse in all difficulties regarding CR (Correct Responses) and RT (Reaction Time). Both variables, RT and CR, were significantly impaired in patients with PCS compared to controls. Significant differences in RT for choosing the correct stereoscopic stimulus were found ranging from 147 ms, 167 ms to 183 ms for RT from easiest to hardest difficulty. | |||||||||||||||||||||
584 | Assessing acute kidney injury risk after COVID vaccination and infection in a large cohort study | 2024-11-08 | https://doi.org/10.1038/s41541-024-00964-3 | Yuanyi Pan | https://www.nature.com/articles/s41541-024-00964-3 | The absolute risk of AKI (Acute Kidney Injiry) was 0.66% in the vaccination group versus 4.88% in the infection group. After adjusting for various confounders, COVID-19 infection was associated with a significantly higher risk of AKI than COVID-19 vaccination (aHR = 10.31, P < 0.001). Our study reveals that COVID-19 vaccination is associated with a significant lower AKI risk compared to COVID-19 infection. | |||||||||||||||||||||
585 | Long-term health outcomes of COVID-19 in ICU- and non-ICU-treated patients up to 2 years after hospitalization: a longitudinal cohort study (CO-FLOW) | 2024-11-08 | https://doi.org/10.1186/s40560-024-00748-w | J. C. Berentschot | https://link.springer.com/article/10.1186/s40560-024-00748-w | 73% (322/443) of patients had not completely recovered from COVID-19, with memory problems (274/443; 55%), concentration problems (259/443; 52%), and dyspnea (251/493; 51%) among most frequently reported symptoms at 2 years. Moreover, 61% (259/427) had poor sleep quality, 51% (222/433) fatigue, 23% (102/438) cognitive failures, and 30% (65/216) did not fully return to work. Most outcomes were comparable between ICU- and non-ICU-treated patients at 2 years. However, ICU-treated patients tended to show slower recovery in neurocognitive symptoms, mental health outcomes, and resuming work than non-ICU-treated patients. | |||||||||||||||||||||
586 | Change in frailty among older COVID-19 survivors | 2024-11-09 | https://doi.org/10.1111/jgs.19255 | Benjamin Seligman | https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.19255 | We found a greater increase in frailty among older Veterans with COVID-19 compared with matched uninfected controls, suggesting that COVID-19 infection has long-term implications for vulnerability and disability among older adults. After adjustment, those with COVID-19 accrued 1.54 (95% CI 1.52–1.56) times more deficits than those who did not. The five most common new deficits were fatigue (9.7%), anemia (6.8%), muscle atrophy (6.5%), gait abnormality (6.2%), and arthritis (5.8%). | |||||||||||||||||||||
587 | Burden of post–acute COVID-19 sequelae in healthcare workers and its course over a 30-month period–results from a prospective multicentre cohort | 2024-11-12 | https://doi.org/10.1007/s15010-024-02418-3 | Tamara Dörr | https://link.springer.com/article/10.1007/s15010-024-02418-3 | 30.7% reported ≥ 1 PASC symptom in 10/2023, with 115 (6.7%) stating to have or have had PASC. Both were most common after Wild-type infection compared to other variants. Overall, 17/115 (15%) indicated relevant/severe restrictions in their daily activities. | |||||||||||||||||||||
588 | Post-Coronavirus Disease 2019 Effects in an Active University Population: A Within-Campus Cross-Sectional Study at a Major Educational Institution | 2024-11-12 | https://doi.org/10.1016/j.mayocpiqo.2024.09.004 | Marcelo Hernández-Mora | https://www.mcpiqojournal.org/article/S2542-4548(24)00065-1/fulltext | Post-COVID-19 symptoms arose at least 2 weeks after recovery from the initial illness; 654 individuals reported at least one symptom after the acute COVID-19 period, for a post-COVID-19 prevalence of 74.96%. The most frequent symptoms were fatigue (84%), headache (71%), and difficulty concentrating (71%). | |||||||||||||||||||||
589 | Incidence and predictors of clinical failure after early treatment for mild-to-moderate COVID-19 in high-risk individuals: A multicentric cohort study | 2024-11-13 | https://doi.org/10.1111/joim.20030 | Ilaria Mastrorosa | https://onlinelibrary.wiley.com/doi/10.1111/joim.20030 | Older age, lack of complete vaccination coverage, and established immunosuppression seem to remain important risk factors for COVID-19 morbidity and mortality despite timely administration of early treatment for mild-to-moderate COVID-19, even with most recent Omicron subvariants. Indeed, our data suggest that the immunocompromised status emerged as a critical risk factor for severe disease/death, especially in the Omicron wave of the pandemic. | |||||||||||||||||||||
590 | Trajectories of functional limitations, health-related quality of life and societal costs in individuals with long COVID: a population-based longitudinal cohort study | 2024-11-13 | https://doi.org/10.1136/bmjopen-2024-088538 | Jiunn Wang | https://bmjopen.bmj.com/content/14/11/e088538 | Individuals referred to long COVID clinics in the UK reported little improvements in functional limitations, fatigue and HRQL (health-related quality of life) over the first 6 months after registration in the LWCR (Living With Covid Recovery) programme. Our analysis suggested that almost half of long COVID patients were expected to have moderately severe or worse functional impairment at 6 months, emphasising ongoing challenges in long COVID recovery. While long COVID-related healthcare utilisation remained relatively constant over the 6-month period, the average number of working days lost increased slightly over time. Over one-third of these were unable to work at all. | |||||||||||||||||||||
591 | Manipulation of Host Cholesterol by SARS-CoV-2 | 2024-11-14 | https://doi.org/10.1101/2024.11.13.623299 | Aliza Doyle | https://www.biorxiv.org/content/10.1101/2024.11.13.623299v1 | In summary, our findings suggest mechanisms by which SARS-CoV-2 infection disrupts host cell lipid metabolism through lysosomal cholesterol sequestration. An imbalance in these lipids could contribute to the organelle dysfunction observed in SARS-CoV-2 infection, potentially affecting immune responses, autophagy, and cellular energy regulation, as well as contributing to the persistent symptoms seen in long COVID. | |||||||||||||||||||||
592 | Symptom profile, case and symptom clustering, clinical and demographic characteristics of a multicentre cohort of 1297 patients evaluated for Long-COVID | 2024-11-14 | https://doi.org/10.1186/s12916-024-03746-9 | Marco Floridia | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03746-9 | Fatigue (55.9%) and dyspnea (47.2%) were the most frequent symptoms. Women reported more symptoms (3.6 vs. 3.1, p < 0.001), with a significantly higher prevalence of memory loss, difficult concentration, cough, palpitation or tachycardia, dermatological abnormalities, brain fog, headache and visual disturbances. Dyspnea was more common in men. | |||||||||||||||||||||
593 | Investigating DNA damage caused by COVID-19 and influenza in post COVID-19 | 2024-11-14 | https://doi.org/10.1007/s00335-024-10082-z | Elaheh Abiri | https://link.springer.com/article/10.1007/s00335-024-10082-z | During the epidemic peak, the levels of DNA damage ranged from the highest to the lowest levels in the following groups, respectively: intubated-ICU, non-intubated-ICU, non-ICU, and influenza, with a discernible increase in DNA damage in ICU-treated patients. The levels of DNA damage in the post-COVID-19 period were significantly lower compared to those in the epidemic peak period but there was still a discernible increase in DNA damage in the ICU group. | |||||||||||||||||||||
594 | Long-term recovery in critically ill COVID-19 survivors: A prospective cohort study | 2024-11-14 | https://doi.org/10.1111/aas.14550 | Ingrid Didriksson | https://onlinelibrary.wiley.com/doi/10.1111/aas.14550 | The percentage of participants with a good functional outcome increased from 35% to 64% between 3 and 12 months (p < .001). Although our study shows a significant increase in participants returning to work between 3 and 12 months, almost 1 in 3 pre-event workers had not.These findings, together with our results, highlight the profound and enduring effects of COVID-19 on ICU survivors and suggest that COVID-19 may be evolving into a chronic condition for some while having potential for improvements beyond the first year for others. | |||||||||||||||||||||
595 | Mast Cell Carboxypeptidase A3 Is Associated with Pulmonary Fibrosis Secondary to COVID-19 | 2024-11-14 | https://doi.org/10.3390/ijms252212258 | Yatsiri G. Meneses-Preza | https://www.mdpi.com/1422-0067/25/22/12258 | These results suggest that during COVID-19, exacerbated inflammation favors the recruitment or expansion of MCs (mast cells) and CPA3 expression in the lungs, which favors tissue damage and a failure of repair mechanisms, leading to fibrosis. | |||||||||||||||||||||
596 | The Short and Long of COVID-19: A Review of Acute and Chronic Radiologic Pulmonary Manifestations of SARS-2-CoV and Their Clinical Significance | 2024-11-14 | https://doi.org/10.1016/j.rdc.2024.09.004 | Scott Simpson | https://www.sciencedirect.com/science/article/abs/pii/S0889857X2400070X | Chronic CT (computed tomography) manifestations are predominately seen in those with moderate to severe disease. Specific CT features of post-COVID-19 pneumonia fibrosis include traction bronchiectasis, architectural distortion, and rarely honeycombing. | |||||||||||||||||||||
597 | Long COVID Following Mild SARS-CoV-2 Infection: A Retrospective Study in a Portuguese Primary Health Care Unit | 2024-11-14 | 10.7759/cureus.73655 | Barata A | https://www.cureus.com/articles/310989-long-covid-following-mild-sars-cov-2-infection-a-retrospective-study-in-a-portuguese-primary-health-care-unit#!/ | A total sample of 334 (56% female) was recruited for this study. The prevalence of long COVID was found to be 145 (43.4%) cases in the near months (>/= 3 months) following COVID-19 and 57 (17.1%) cases after two years. About 58 (17.4%) patients reported that their self-care capacity became worse after COVID-19. In the further evaluation of functional status, 56 (16.8%) patients reported that walking a distance of at least 1 km is more difficult nowadays, and 29 (8.7%) reported that performing household tasks became harder. | |||||||||||||||||||||
598 | A cross-sectional study of fundus lesion characteristics in patients with acute visual impairment caused by COVID-19 infection | 2024-11-15 | https://doi.org/10.1038/s41598-024-79509-6 | Jia Wei | https://www.nature.com/articles/s41598-024-79509-6#citeas | COVID-19 infection can lead to acute, bilateral, symmetric, and widespread retinal damage. | |||||||||||||||||||||
599 | Post-acute sequalae of COVID-19 three to twelve months after infection: Delta versus Omicron | 2024-11-15 | https://doi.org/10.1016/j.ijid.2024.107302 | Siméon de Bruijn | https://www.sciencedirect.com/science/article/pii/S1201971224003783 | PASC prevalence was 34.3% at T3 (3 months) and decreased to 21.7% at T12 (12 months) for Delta and decreased from 18.7% at T3 to 16.7% at T12 for Omicron. At T12 the difference between Delta and Omicron was not significant. Delta cases generally had higher excess symptom scores for fatigue, dyspnoea and cognitive impairment than Omicron. | |||||||||||||||||||||
600 | Effects of acute-phase COVID-19-related indicators on pulmonary fibrosis and follow-up evaluation | 2024-11-15 | https://doi.org/10.21203/rs.3.rs-5103911/v1 | Qiong Wang | https://www.researchsquare.com/article/rs-5103911/v1 | The incidence of pulmonary fibrosis post-COVID-19 increases with disease severity. The incidence of pulmonary fibrosis was 4.37%, with 2.08% in moderate cases and 8.22% in severe cases. Quantitative chest CT analysis revealed significant differences in lung reticular lesions, consolidation, and GGO volumes but no significant difference in honeycomb volume. | |||||||||||||||||||||
601 | Functional Outcome after Clinical Recovery from Moderate to Critical COVID-19 among Patients Admitted to the Philippine General Hospital: A Prospective Cohort Study | 2024-11-15 | https://doi.org/10.47895/amp.v58i20.8479 | Micah G. Catalan | https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/8479 | COVID-19 significantly affects the functional outcome of patients in terms of activities of daily living as measured by the Barthel Index. Across all patients, Barthel Index Score at discharge indicated a significant decline from slight dependence to moderate dependence in performing activities of daily living with the pre-morbid status significantly predicting scores at discharge (β = 0.621, p = 0.001) on multiple regression analysis. | |||||||||||||||||||||
602 | Lasting liver injury following COVID-19 infection characterized by ultrasound shear wave elastography | 2024-11-17 | https://doi.org/10.1016/j.wfumbo.2024.100074 | Firouzeh Heidari | https://www.sciencedirect.com/science/article/pii/S2949668324000429 | COVID-19 infection is associated with increased liver stiffness, which may reflect lasting hepatic injury such as ongoing inflammation or the development of fibrosis. SWE scans were performed on General Electric LOGIQ E9 or E10 an average of 44 (range, 12–81) weeks after COVID-19 infection. Post-COVID-19 patients had higher liver stiffness compared to contemporaneous controls (median = 7.58 vs 5.99 kPa, p = 0.001) but not pre-pandemic controls (median = 7.00 kPa, p = 0.51). | |||||||||||||||||||||
603 | Post-COVID recovery is faster after an infection with the SARS-CoV-2 Omicron variant: a population-based cohort study | 2024-11-18 | https://doi.org/10.1007/s15010-024-02438-z | Laura Rebecca Pfrommer | https://link.springer.com/article/10.1007/s15010-024-02438-z | Although the recovery from PCC is faster for the newer virus variants, still a substantial fraction of those who developed PCC after an infection with the Omicron variant report prolonged persistence of symptoms. Among the 4,529 respondents with PCC included in our analyses, about 26%, 19%, 36%, and 44% of those infected during dominance of the SARS-CoV-2 wildtype, Alpha, Delta, and Omicron variant had recovered one year after infection, respectively. | |||||||||||||||||||||
604 | Altered leukocyte pattern and inflammatory markers in unvaccinated long covid patients: a cross-sectional study | 2024-11-19 | https://doi.org/10.1038/s41598-024-75920-1 | Elem Cristina Rodrigues Chaves | https://www.nature.com/articles/s41598-024-75920-1 | We suggest that Long Covid patients may exhibit alterations in inflammatory markers, indicating a persistently pro-inflammatory microenvironment that tends to diminish after 12 months of Long Covid. Higher eosinophil counts were observed in patients with up to three months of Long Covid, and increased monocyte counts in those with up to six months. IL-2 levels were higher in patients with fewer symptoms and Long Covid duration of more than three months, whereas IL-10 may remain elevated for up to 12 months. | |||||||||||||||||||||
605 | Red Blood Cell Morphology Is Associated with Altered Hemorheological Properties and Fatigue in Patients with Long COVID | 2024-11-19 | https://doi.org/10.3390/biology13110948 | Marijke Grau | https://www.mdpi.com/2079-7737/13/11/948 | This study highlights persistent significant changes in RBC (red blood cell) rheological parameters and RBC morphology in Long-COVID patients. These include increased RBC aggregation, altered deformability, and a higher proportion of abnormally shaped RBCs, all of which may collectively negatively affect blood flow and therefore oxygen supply in vivo. | |||||||||||||||||||||
606 | Insights into the Risk Factors and Outcomes of Post-COVID-19 Syndrome—Results from a Retrospective, Cross-Sectional Study in Romania | 2024-11-20 | https://doi.org/10.3390/life14111519 | Ioana Bejan | https://www.mdpi.com/2075-1729/14/11/1519 | Out of 549 respondents, (male:female ratio: 0.32), 29.5% had persistent symptoms at 3 months, 23.5% had persistent symptoms at 6 months, and 18.3% had persistent symptoms at 12 months after the initial infection. Individuals with post-COVID-19 syndrome had a 5.7-fold higher risk of being diagnosed with a new chronic condition, with 44% reporting cardiovascular disease, and a 6.8-fold higher likelihood of needing medical care or leave. Affected individuals reported significant impairments in mobility, pain/discomfort, and anxiety/depression, with 20.7% needing to adjust their work schedules. | |||||||||||||||||||||
607 | Predictors of Long COVID Among Symptomatic US Adults Testing Positive for SARS-CoV-2 at a National Retail Pharmacy | 2024-11-21 | https://doi.org/10.3390/healthcare12232321 | Xiaowu Sun | https://www.mdpi.com/2227-9032/12/23/2321 | The prevalence of long COVID defined as ≥3 symptoms at Month 6 was 35.0% (2022) and 18.2%, (2023) respectively. The risk factors associated with long COVID were older age, female sex, lack of up-to-date vaccination, number of acute symptoms on the day of SARS-CoV-2 testing, increase in symptoms at Week 1, underlying comorbidities and asthma/chronic lung disease. | |||||||||||||||||||||
608 | A study of comparing between auditory manifestations in post-COVID 2019 and 2023 | 2024-11-22 | https://doi.org/10.1186/s43163-024-00704-3 | Heba Tallah sherif Abd El Hady | https://link.springer.com/article/10.1186/s43163-024-00704-3 | SNHL (sensorineural hearing loss) was more than CHL (Conductive hearing loss) in post-COVID 2019. On the other hand, in post COVID-2023 cases CHL was more than SNHL.24% in post COVID-19 and 16% in post COVID-23 were manifested with severe symptoms showing decrease in the number of severe cases in both COVID-19 and COVID-23. | |||||||||||||||||||||
609 | Recovery and long-term health outcomes of SARS-CoV-2 infection in a prospective cohort in an urban setting, Kenya | 2024-11-22 | https://doi.org/10.1101/2024.11.21.24316116 | Isaac Kisiangani | https://www.medrxiv.org/content/10.1101/2024.11.21.24316116v1 | Six months post-infection, half of participants had lingering symptoms, with a third still affected after a year. At 6 and 12 months post-positive PCR, 53.1% and 33.5% had ≥1 COVID-19-related symptoms, respectively. Fatigue (40.2%), pain (36.8%), sore throat (36.8%), headaches (36.4%), and loss of strength (31.6%) were the most frequently reported symptoms. | |||||||||||||||||||||
610 | Systematic review and meta-analysis of COVID-19 association with human semen quality: Changes in semen parameters pre- and post-COVID | 2024-11-22 | https://doi.org/10.1002/uro2.92 | Wempy Supit | https://onlinelibrary.wiley.com/doi/10.1002/uro2.92 | This study revealed the susceptibility of semen parameter impairments in association with COVID-19. Compiled data from a total of 153 participants revealed that COVID-19 is associated with semen quality impairment, with meta-analysis showing significant decrease of sperm concentration and progressive motility. | |||||||||||||||||||||
611 | Post-COVID-19 dry eye negatively impacts the patient’s quality of life | 2024-11-22 | https://doi.org/10.5935/0004-2749.2024-0112 | Rosalia Antunes-Foschini | https://www.scielo.br/j/abo/a/pnQ7hssqyj5PFQgfT8fzqvk/?lang=en | There is a significant negative correlation between the proportion of patients with dry eye disease and their self-reported quality of life. 26.3% of COVID-19 survivors presented severe dry eye symptoms or had a history of DED. This is higher than the prevalence in previous studies (4.2%). | |||||||||||||||||||||
612 | Cardiorespiratory fitness response to endurance training in athletes post-COVID-19 compared to unaffected athletes | 2024-11-25 | https://doi.org/10.17159/2078-516X/2024/v36i1a18872 | Cheryl Haley | https://journals.assaf.org.za/index.php/sajsm/article/view/18872 | Increased odds of pulmonary and skeletal muscle limitation to aerobic capacity were found in the COVID-19 group. The post-COVID-19 exposure group (n=57), mean age 44.5±8.1 years showed a poorer ventilatory threshold (p=0.004), and workload (p=0.05), with higher respiratory exchange ratio (p=0.05) than the control group (n=34), mean age 41.8±7.7 years. | |||||||||||||||||||||
613 | Tinnitus and COVID-19: effect of infection, vaccination, and the pandemic | 2024-11-25 | https://doi.org/10.3389/fpubh.2024.1508607 | Yihsin Tai | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1508607/full | Tinnitus severity (estimated using TFI scores) was significantly lower in the pre-existing tinnitus group than in any of the COVID-associated tinnitus groups. While varying factors were found to contribute to tinnitus severity among the COVID-associated groups, overall, depression and/or anxiety accounted for the most variance in predicting tinnitus severity. | |||||||||||||||||||||
614 | A predictive model for post-COVID-19 pulmonary parenchymal abnormalities based on dual-center data | 2024-11-26 | https://doi.org/10.1038/s41598-024-79715-2 | Xiujuan Yao | https://www.nature.com/articles/s41598-024-79715-2 | Our investigation, focusing on Omicron variant survivors three months post-hospital discharge, documented a 33% prevalence of residual lung abnormalities via CT. | |||||||||||||||||||||
615 | Severity of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Diminished during Successive Waves of the COVID-19 Pandemic: Data from a Nationwide German Survey | 2024-11-26 | https://doi.org/10.1016/j.jpeds.2024.114419 | Florens Lohrmann | https://www.sciencedirect.com/science/article/pii/S0022347624005225 | During the course of COVID-19 pandemic, as each new VOC emerged, PIMS-TS (Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2) lessened in severity. In parallel, older children came to experience more debilitating disease. Based on clinical symptoms, laboratory and diagnostic findings, and ICU admission rates, older children, irrespective of the related VOC (variants of concern), were shown to experience more severe, acute PIMS-TS. | |||||||||||||||||||||
616 | The Physical Condition and Mental Health of Chinese College Students 3 Months After COVID-19 Recovery | 2024-11-26 | https://doi.org/10.1177/15598276241303692 | Yue-yang Wu | https://journals.sagepub.com/doi/10.1177/15598276241303692 | 13.2% with severe impairment (cluster 1), 27.2% with mild physical symptoms (cluster 2), and 59.5% with no or mild symptoms (cluster 3). The students who smoked, drank alcohol, did not exercise, or had a history of underlying medical conditions were more likely to have moderate to severe symptoms. | |||||||||||||||||||||
617 | Dermatological complications due to post‑COVID‑19 syndrome: A systematic review | 2024-11-26 | https://doi.org/10.3892/mi.2024.208 | Beatriz Arely Cayón Figueroa | https://www.spandidos-publications.com/10.3892/mi.2024.208 | The present systematic review found that the dermatological manifestations of post-COVID-19 syndrome are primarily hair loss and skin lesions associated with persistent inflammation and the development of autoimmunity, with the severity of the initial clinical presentation and female sex being risk factors for severity. | |||||||||||||||||||||
618 | Healthcare utilisation of 282,080 individuals with long COVID over two years: a multiple matched control, longitudinal cohort analysis | 2024-11-27 | https://doi.org/10.1177/01410768241288345 | Yi Mu | https://journals.sagepub.com/doi/10.1177/01410768241288345 | LC has been associated with substantial, persistent healthcare utilisation and cost over the last three years. Healthcare utilisation per person (per month/year) was higher in LC than controls across GP, OP and ED (primary care (general practitioner [GP]), secondary care (outpatient [OP] and emergency department [ED]). Healthcare utilisation of the LC group increased progressively between 2020 and 2023, compared with controls. Median cost per patient/year was also higher in individuals with LC than all control groups. | |||||||||||||||||||||
619 | Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study) | 2024-11-27 | https://doi.org/10.1289/EHP15377 | Apolline Saucy | https://ehp.niehs.nih.gov/doi/10.1289/EHP15377 | Between 2021 and 2023, the cumulative incidence of long COVID among those infected (𝑛=2,853) was 24.5% (𝑛=700) and 5% for persistent long COVID (𝑛=153). Prevalence of long COVID was higher among those with prior chronic diseases (33.3%, 𝑛=1,013) compared to those without (19.7%, 𝑛=1,840) and among those with severe COVID-19 (71.8%, 𝑛=85) compared to those with mild/moderate COVID-19 (25.1%, 𝑛=2,380) or those asymptomatic (10.3%, 388). | |||||||||||||||||||||
620 | Persistent Symptoms (Lasting Longer than 1 Year) in Children Hospitalized with Acute COVID-19 Versus Other Conditions | 2024-11-27 | https://doi.org/10.3390/children11121444 | Marta Conde | https://www.mdpi.com/2227-9067/11/12/1444 | We identified a non-significant difference in the prevalence of persistent symptoms 1 year after hospitalization between children and young people (CYP) with acute COVID-19 and those hospitalized for non-COVID-19-related conditions. Symptoms persisted ≥12 months in 14/50 (28%) COVID-19 participants and in 7/46 (15%) non-COVID-19 participants (p = 0.140). Readmissions occurred in 11/50 (22%) COVID-19 participants and in 6/46 (13%) non-COVID-19 participants (p = 0.267). | |||||||||||||||||||||
621 | Predictors of hospitalisation, death and incomplete/non-recovery from SARS-CoV-2 in an ambulatory global population | 2024-11-27 | https://doi.org/10.1016/j.ijid.2024.107285 | The STRIVE ICOS and PCOS Study Groups | https://www.sciencedirect.com/science/article/pii/S1201971224003564 | Symptomatic recovery and return to pre-morbid health were incomplete at 28 days in one third. At 28 days, 26·1% and 29.9% reported ongoing symptoms and failure to return to pre-morbid health respectively. | |||||||||||||||||||||
622 | Altered gut microbiome in convalescent patients with coronavirus disease 2019 | 2024-11-27 | https://doi.org/10.3389/fcimb.2024.1455295 | Kyoung Hwa Lee | https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1455295/full | At the order level, Eubacteriales and Bifidobacteriales decreased, while Bacteroidales and Burkholderiales increased in the COVID-19 group compared to the controls. Alpha diversity also decreased in COVID-19 patients compared to controls, with imperfect recovery of the gut microbiome after seven months. Specifically, our results suggest that SARS-CoV-2 infection leads to a decreased abundance of symbionts and an increased proportion of opportunistic pathogens. | |||||||||||||||||||||
623 | Insomnia, cardiorespiratory function and quality of life in individuals with post-COVID-19 fatigue | 2024-11-27 | https://doi.org/10.1016/j.sleepx.2024.100135 | PMC11803148 | Nathalea Spode de Arruda | https://pmc.ncbi.nlm.nih.gov/articles/PMC11803148/ | Individuals with post-COVID-19 fatigue demonstrated a higher prevalence of insomnia (80% vs. 49%) and excessive daytime sleepiness (45% vs. 7%), as well as lower MIP, shorter distance covered in the 6MWT, and lower FEV1/FVC (forced expired volume in the first second divided by forced vital capacity), and FEV1/FVC% of predicted. Additionally, they exhibited poorer quality of life in the physical and environmental domains. | ||||||||||||||||||||
624 | Evaluation of the Peripheral and Central Auditory Systems in Children and Adolescents Before and After COVID-19 Infection | 2024-11-28 | https://doi.org/10.3390/children11121454 | Julia Siqueira | https://www.mdpi.com/2227-9067/11/12/1454 | COVID-19 appears to alter the auditory system, both peripherally at the level of the outer hair cells and more centrally. Significant differences were observed between the groups, with the study group showing worse thresholds compared to the control group at both standard audiometric frequencies and at higher frequencies, although both groups were still within normal limits (p ≤ 0.05). In addition, the study group had a higher prevalence of absent responses, as identified by otoacoustic emissions and acoustic reflexes. | |||||||||||||||||||||
625 | Long-Term Outcomes of Critically Ill COVID-19 Survivors: A three-year Follow-up Study | 2024-11-29 | https://doi.org/10.1016/j.chstcc.2024.100116 | María Zuil | https://www.sciencedirect.com/science/article/pii/S2949788424000704 | Significant improvements in pulmonary function, particularly in DLCO, were observed after 24 months, but half of the patients still exhibited radiological sequelae, with some showing disease progression beyond two years. No deaths have occurred since the second year, but 26.1% remain unable to work. | |||||||||||||||||||||
626 | Endothelial Glycocalyx Anomalies and Ocular Manifestations in Patients with Post-Acute COVID-19 | 2024-11-29 | https://doi.org/10.3390/jcm13237272 | Georges Azar | https://www.mdpi.com/2077-0383/13/23/7272 | Patients with post-acute COVID-19 have frequent ophthalmological anomalies mainly including ocular surface disease and retinal capillary non-perfusion. They seem to have normalization of the glycocalyx function but an abnormal CD and microvascular bed. The symptoms reported by post-acute COVID-19 patients seem to be the result of microvascular rarefaction and damage to the capillary bed. | |||||||||||||||||||||
627 | Decreased levels of vitamin D in Post-Corona Virus-19 Disease syndrome (PCS) patients compared to a control group | 2024-11-29 | https://doi.org/10.1016/j.clnesp.2024.11.023 | Jens Bräunlich | https://clinicalnutritionespen.com/article/S2405-4577(24)01540-7/abstract | We found significantly lower (p<0,05) vitamin D levels in the PCS cohort (2021: 17,04±8,0 ng/ml; 2022: 17,6±6,6 ng/ml) compared to all years of the non-PCS group (2019: 23,7±14,7 ng/ml; 2020:22,3±13,7 ng/ml; 2021: 22,4±12,3 ng/ml; 2022: 22,6±11,0 ng/ml). This raises the question of whether vitamin D deficiency influences PCS symptoms or whether they are merely the consequences of the limitations of PCS. | |||||||||||||||||||||
628 | ‘Every Run Is Hard’: Endurance Athletes’ Experiences of Return to Sports Participation After COVID-19—A Mixed Methods Study | 2024-11-29 | https://doi.org/10.1155/2024/1506534 | Cheryl Anne Haley | https://onlinelibrary.wiley.com/doi/10.1155/2024/1506534 | Athletes’ QOL (Quality of Life) deteriorated due to protracted RTS (return to sports) after COVID-19. Barriers to exercise included tachycardia (72%), fatigue (72%), dyspnoea (58%) and inability to exercise at high intensities (75%). High physical and mental fatigue scores were found, the former significantly predicting return to sport. | |||||||||||||||||||||
629 | Long COVID in healthcare workers: longitudinal mixed-methods study | 2024-11-29 | https://doi.org/10.1093/occmed/kqae113 | A Grant | https://academic.oup.com/occmed/advance-article/doi/10.1093/occmed/kqae113/7914095?login=false | All participants experienced various relapsing, remitting, changing and prolonged LC symptoms (mean 7.1 [SD 4.8] at S2) and a third reported day-to-day activities ‘limited a lot’. Most participants were working in a reduced capacity: reduced hours, different role or location. Participants feared reinfection, their future, ability to work and financial security (59% (n = 174) at S2). | |||||||||||||||||||||
630 | Association Between COVID-19 and Orthostatic Intolerance in Children: A Retrospective Study | 2024-11-30 | 10.7759/cureus.74857 | Bahram Kakavand | https://www.cureus.com/articles/319746-association-between-covid-19-and-orthostatic-intolerance-in-children-a-retrospective-study#!/ | This study highlights the growing incidence of POTS and other forms of OI in pediatric patients following COVID-19 infection and vaccination, supporting the link between COVID-19 and autonomic dysfunction in children. In this study, we presented a series of 16 pediatric patients who developed OI symptoms following SARS-CoV-2 infection or after the COVID-19 vaccine. Of these patients, 62.5% (10 patients) were diagnosed with POTS, and 43.75% (seven patients) showed evidence of cardiac-autonomic dysfunction based on an abnormal Valsalva maneuver. | |||||||||||||||||||||
631 | Prediction of impaired lung diffusion capacity in COVID-19 pneumonia survivors | 2024-11-30 | 10.21037/jtd-24-1118 | Olga I. Savushkina | https://jtd.amegroups.org/article/view/93060/html | Pulmonary interstitial damage caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) definitely contributes to reduced DLco (diffusion capacity for carbon monoxide) after hospital discharge. Abnormal DLco (<80% of predicted) was recorded in 60.4% cases. | |||||||||||||||||||||
632 | Productive infection of the retinal pigment epithelium by SARS-CoV-2: Initial effects and consideration of long-term consequences | 2024-12-03 | https://doi.org/10.1093/pnasnexus/pgae500 | Nan W Hultgren | https://academic.oup.com/pnasnexus/article/3/12/pgae500/7911947?login=false | Our findings suggest that post-acute sequelae of SARS-CoV-2 infection of the RPE (retinal pigment epithelium) may have long-term implications for vision, perhaps comparable to the increased occurrence of AMD (age-related macular degeneration) found among individuals infected by HIV, but with greater public health consequences due to the much larger number of SARS-CoV-2 infections. | |||||||||||||||||||||
633 | A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people | 2024-12-04 | https://doi.org/10.1038/s43856-024-00657-x | Terence Stephenson | https://www.nature.com/articles/s43856-024-00657-x | 7.2% of CYP (Children and Young People) consistently fulfil the PCC definition at 3-, 6-, 12- and 24-months. These CYPs have a median of 5-to-6 symptoms at each time-point. Between 20% and 25% of all infection status groups report 3+ symptoms 24-months post-testing; 10–25% experience 5+ symptoms. | |||||||||||||||||||||
634 | Interaction between type 2 diabetes and past COVID-19 on active tuberculosis | 2024-12-04 | https://doi.org/10.1186/s12879-024-10244-z | Liz E. Calles-Cabanillas | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-10244-z | The odds of new TB were higher among past COVID-19 cases vs. controls, but only significant among DM patients (aOR 2.3). The odds of TB in people with DM was 2.7-fold higher among participants without past COVID-19 and increased to 7.9-fold among those with past COVID-19. | |||||||||||||||||||||
635 | Retrospective Cohort Study of Perioperative Complications in Symptomatic and Asymptomatic Children Testing SARS-CoV-2-Positive Within 21 Days Before Surgery | 2024-12-05 | https://doi.org/10.1111/pan.15051 | Anitra Karthic | https://onlinelibrary.wiley.com/doi/10.1111/pan.15051 | Preoperative symptoms, especially of the lower respiratory tract, increased the risk for perioperative complications in children diagnosed with COVID-19 within 10 days of surgery. Symptomatic patients were more likely to experience postoperative respiratory complications (OR: 3.53, 1.18–10.6, p = 0.024), require postoperative medications (OR: 7.64, 2.29–25.51, p = 0.001), and require postoperative oxygen support (OR: 2.62, 1.19–5.79, p = 0.017) versus asymptomatic patients. | |||||||||||||||||||||
636 | The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil | 2024-12-05 | https://doi.org/10.1016/j.puhe.2024.10.016 | Tarsila Vieceli | https://www.sciencedirect.com/science/article/pii/S003335062400427X | Influenza had lower odds for requiring ICU admission, mechanical ventilation and in-hospital mortality compared to COVID-19 only. Influenza had lower odds for requiring ICU admission (aOR 0.68, 95 % CI, 0.65–0.72, p < 0.001), iMV (aOR 0.74, 95 % CI, 0.69–0.80, p < 0.001), and in-hospital mortality (aOR 0.51, 95 % CI, 0.48–0.54, p < 0.001), compared to COVID-19 only. | |||||||||||||||||||||
637 | Higher Post-Acute Health Care Costs Following SARS-CoV-2 Infection Among Adults in Ontario, Canada | 2024-12-05 | https://doi.org/10.2147/JMDH.S465154 | McNaughton CD | https://www.dovepress.com/higher-post-acute-health-care-costs-following-sars-cov-2-infection-amo-peer-reviewed-fulltext-article-JMDH | Post-acute health care costs after a positive SARS-CoV-2 PCR test were significantly higher than matched test-negative individuals, and these increased costs persisted for at least one year. Mean person-specific total health care costs were $513.83 (95% CI $387.37-$638.40) higher for test-positive females and $459.10 (95% CI $304.60-$615.32) higher for test-positive males, which were driven by hospitalization, long-term care, and complex continuing care costs. | |||||||||||||||||||||
638 | Impact of SARS-CoV-2 Infection on Physical Fitness in Air Force Basic Trainees | 2024-12-05 | https://doi.org/10.1093/milmed/usae542 | Elena Crouch | https://academic.oup.com/milmed/advance-article-abstract/doi/10.1093/milmed/usae542/7916758?login=false | The infected group had a higher rate of failing their PT (physical fitness test) at the end of training when compared to control (15.7% vs. 4.3%, P < .001). When comparing those who passed their first fitness test and went on to fail their second fitness test, this occurred more frequently in the infected group (2.3% vs. 0.81%, P = .037). Among the infected group, there were no differences in second test failure rates when comparing symptomatic to asymptomatic trainees (16.9% vs. 11.8%, P = .143). | |||||||||||||||||||||
639 | The relationship between long COVID, labor productivity, and socioeconomic losses in Japan: A cohort study | 2024-12-05 | https://doi.org/10.1016/j.ijregi.2024.100495 | Shunichiro Konishi | https://www.sciencedirect.com/science/article/pii/S2772707624001644 | In total, 29.3% of the patient cohort continued to experience long COVID symptoms 1 year after COVID-19 diagnosis. At all three time points (3, 6, and 12 months after diagnosis), the long COVID persistent group showed a statistically significant difference in absolute presenteeism compared with the non-long COVID and long COVID recovered groups (P <0.01). Economic loss owing to decrease in labor productivity was calculated as $21,659 per year in the long COVID persistent group and $9008 per year in the long COVID recovered group (P <0.01). | |||||||||||||||||||||
640 | Exploring social determinants of health and their impacts on self-reported quality of life in long COVID-19 patients | 2024-12-06 | https://doi.org/10.1038/s41598-024-81275-4 | Anh Pham | https://www.nature.com/articles/s41598-024-81275-4 | This study underscores the profound impact of Long COVID on health-related quality of life. The low HRQoL (health-related quality of life) scores (mean 55.8) from self-assessments indicates profound impacts on HRQoL. In comparison to the mean EQ-VAS population norm of 82.3 for Canadians, 89% of patients with Long COVID in this cohort had HRQoL scores lower than the norm, while 50% had a score lower than 60. | |||||||||||||||||||||
641 | Acute hepatitis of unknown aetiology in children: evidence for and against causal relationships with SARS-CoV-2, HAdv and AAV2 | 2024-12-09 | https://doi.org/10.1136/bmjpo-2023-002410 | Deepti Gurdasani | https://bmjpaedsopen.bmj.com/content/8/1/e002410 | HAdv (human adenovirus) alone is unlikely to be the cause of the recent increase in hepatitis in children. The causal link between SARS-CoV-2, and to a lesser degree AAV-2 (adeno-associated virus 2), appears substantially stronger but remains unproven. Hepatitis is a known complication of multisystem inflammatory syndrome in children following COVID-19, and SARS-CoV-2 has been linked to increased susceptibility to infection post-COVID-19. | |||||||||||||||||||||
642 | Multi-Organ Spread and Intra-Host Diversity of SARS-CoV-2 Support Viral Persistence, Adaptation, and a Mechanism That Increases Evolvability | 2024-12-09 | https://doi.org/10.1002/jmv.70107 | Julieta M. Manrique | https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.70107 | Our results indicate that SARS-CoV-2 can replicate, and evolve in a compartmentalized manner, in different body sites, which agrees with the “viral reservoir” theory. The virus was detected in most organs in the majority of autopsies. The iSNV (intra-host single nucleotide variants) abundances observed within different organs indicate that the virus can mutate at one host site and subsequently spread to other parts of the body. | |||||||||||||||||||||
643 | Inflammatory discoveries two years after acute severe COVID-19: a longitudinal biomarker profile assessment in long COVID individuals in the Brazilian Amazon | 2024-12-09 | 10.3389/fimmu.2024.1520193 | Alex Maciel | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1520193/abstract | Although the frequency of long COVID symptoms declines over time after the acute illness, symptoms continue to persist 2 years after hospital discharge. Four months after hospitalization, 91.3% (73/80) of patients exhibited onset of long COVID symptoms, which persisted in 63.7% (51/80) after 2 years. | |||||||||||||||||||||
644 | Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection | 2024-12-10 | https://doi.org/10.3390/diagnostics14242774 | Rachel Pakan | https://www.mdpi.com/2075-4418/14/24/2774 | In patients with ET (Essential Tremor), COVID-19 significantly increases the risk of several long-term adverse health outcomes, but not mortality. COVID-19 was significantly associated with higher risk of MACEs, (aHR = 2.39 [1.49, 3.82]), new-onset sleep disturbance, (aHR = 2.12 [1.44, 3.13]), fatigue, (aHR = 1.83 [1.27, 2.65]), dyspnea, (aHR = 1.98 [1.40, 2.80]), first-time fall, (aHR = 4.76 [2.24, 10.14]), new-onset anxiety, (aHR = 3.66 [2.02, 6.64]), and new-onset depression, (aHR = 2.38 [1.20, 4.70]). | |||||||||||||||||||||
645 | Impact of depressive symptoms on motivation in persons with post-COVID-19 condition | 2024-12-10 | 10.1017/S1092852924000440 | Juliana West | https://www.cambridge.org/core/journals/cns-spectrums/article/impact-of-depressive-symptoms-on-motivation-in-persons-with-postcovid19-condition/B31705AA6037D26BDDACA838EE979831 | Depressive symptoms were associated with motivational deficits in persons living with PCC. There was a statistically significant association between depressive symptoms and BIS (Behavioral Inhibition System), BAS reward responsiveness (Behavioral Activation System), sex , and confirmed COVID-19 infection. | |||||||||||||||||||||
646 | Characteristics of Ocular Findings of Patients with Coronavirus Disease 2019 (COVID-19) in China | 2024-12-11 | 10.3389/fmed.2024.1292821 | Shudan Wang | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1292821/abstract | Individuals with COVID-19 were significantly more likely to experience ocular symptoms. COVID-19 was found to be associated with a higher prevalence of retinal diseases. COVID-19 was found to be associated with a higher prevalence of conjunctivitis, iritis, uveitis, retinal vein occlusion and optic neuritis. The majority of individuals (51.0%) developed eye symptoms after the onset of COVID-19 systemic symptoms. | |||||||||||||||||||||
647 | Long-term Health Implications of Coronavirus Disease 2019: A Prospective Study on Post-coronavirus Disease 2019 Symptoms | 2024-12-12 | 10.4103/aam.aam_199_23 | Savith, Akshatha | https://journals.lww.com/aoam/abstract/9900/long_term_health_implications_of_coronavirus.82.aspx | Approximately one-third of patients who recover from acute COVID-19 infection may continue to have post-COVID-19 symptoms at 1 year after infection. Fatigue is the most common post-COVID-19 symptom. Post-COVID-19 symptoms can affect COVID-19 survivors regardless of the severity of the infection. | |||||||||||||||||||||
648 | Development and validation of the Post-COVID Symptom Scale for Children/Youth (PCSS-C/Y) | 2024-12-13 | https://doi.org/10.1007/s00431-024-05913-9 | Winnie Wan Yee Tso | https://link.springer.com/article/10.1007/s00431-024-05913-9 | Infected cases scored significantly higher on the PCSS-C/Y (Post-COVID Symptom Scale for Children/Youth) when compared to the control cases. For young adult self-report, between 11.8 and 50% of participants rated they had worse symptoms across the 17 items. For adolescent self-report, between 5.5 and 33.6% of participants rated worse symptoms across the 17 items. Adolescents and young adults with a history of COVID-19 were found to have significantly more neurocognitive symptoms than those without a history of COVID-19. | |||||||||||||||||||||
649 | Investigating the Associations Between COVID-19, Long COVID, and Sleep Disturbances: Cross-Sectional Study | 2024-12-13 | https://doi.org/10.2196/53522 | Heng Shao | https://publichealth.jmir.org/2024/1/e53522 | Our findings indicate that long COVID is strongly associated with significant sleep disturbances, while initial COVID-19 infection shows a more moderate association with sleep issues. Sleep latency was significantly longer in the infected group (mean 1.73, SD 0.83) compared to the uninfected group (mean 1.57, SD 0.78; P=.01), and PSQI (Pittsburgh Sleep Quality Index) scores were higher (mean 8.52, SD 4.10 vs. 7.76, SD 4.31; P=.02). Long COVID participants had significantly worse sleep outcomes across all metrics (P<.001) | |||||||||||||||||||||
650 | Surviving COVID-19 and Battling Fibrosis: A Retrospective Cohort Study Across Three Pandemic Waves | 2024-12-13 | https://doi.org/10.3390/diagnostics14242811 | Mihai Lazar | https://www.mdpi.com/2075-4418/14/24/2811 | Lung fibrosis represents a significant post-COVID-19 complication found in 42% of patients with severe forms of pneumonia at the 2-year evaluation. We found fibrosis in 67.9% of patients at the 3-month evaluation and in 42.4% of patients at the 2-year evaluation, registering a significant decrease in the severe and moderate fibrosis cases, with a slight increase in the mild fibrosis cases. | |||||||||||||||||||||
651 | Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study | 2024-12-13 | 10.3389/fcimb.2024.1489936 | Raquel Behar-Lagares | https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1489936/abstract | Depleted specific coagulation factors on ICU admission are associated with increased severity in critically ill COVID-19 patients. Most coagulation alterations recover one-year postdischarge, except for factor IX, aPTT and INR, which remain reduced. | |||||||||||||||||||||
652 | Prevalence of Post–COVID-19 Condition and Activity-Limiting Post–COVID-19 Condition Among Adults | 2024-12-13 | 10.1001/jamanetworkopen.2024.51151 | Anjel Vahratian | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2828033 | In 2023, among 29 522 respondents (NHIS response rate, 47.0%), 8.4% (95% CI, 8.0%-8.8%) of adults in the US reported they ever had PCC, 3.6% (95% CI, 3.3%-3.9%) currently had PCC, and 2.3% (95% CI, 2.1%-2.5%) currently had activity-limiting PCC. Among adults who currently had PCC, 64.5% experienced symptoms that were activity limiting, | |||||||||||||||||||||
653 | Analysis of the long-term effects of COVID-19 infection (long-COVID) in Italy during and after the pandemic emergency and response strategy | 2024-12-16 | https://doi.org/10.19191/EP24.6.A786.135 | Tiziana Grassi | https://epiprev.it/articoli_scientifici/analisi-degli-effetti-a-lungo-termine-dellinfezione-da-covid-19-long-covid-in-italia-durante-e-dopo-lemergenza-pandemica-e-strategia-di-risposta | The results of this study show that long-COVID is a frequent condition in our country, which, due to the amplitude of numbers and the spectrum of symptoms, has a substantial impact on resource consumption. People exposed to SARS-CoV-2 infection, particularly those who were hospitalized, appear to use more healthcare resources in the 6 months following infection than those who were not exposed. Individuals hospitalized in intensive care showed rates of outpatient visits 3 times higher than those who were not exposed and over 4 times higher rates for diagnostic imaging tests and hospitalizations. | |||||||||||||||||||||
654 | Skeletal muscle adaptations and post-exertional malaise in long COVID | 2024-12-17 | https://doi.org/10.1016/j.tem.2024.11.008 | Braeden T. Charlton | https://www.sciencedirect.com/science/article/pii/S1043276024002984 | There is clear evidence of skeletal muscle alterations, including mitochondrial and endothelial abnormalities in patients with long COVID that may underly whole-body exercise responses. Long COVID is associated with intrinsic skeletal muscle mitochondrial dysfunction, endothelial abnormalities, and a shift towards more glycolytic muscle fibers, which contribute to a lower exercise capacity. | |||||||||||||||||||||
655 | Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline | 2024-12-18 | https://doi.org/10.1038/s41390-024-03777-1 | Gina A. Montealegre Sanchez | https://www.nature.com/articles/s41390-024-03777-1 | Infected participants were more likely to report constitutional (OR: 2.24), HEENT (OR: 3.74); respiratory (OR: 2.41), or gastrointestinal (OR: 2.58) symptoms. Infected had worse scores in domains of Pain, Fatigue, Global Health, Physical and Cognitive functioning, Mobility and Sleep disturbances when compared to uninfected controls using Patient Reported Outcomes. | |||||||||||||||||||||
656 | 2024 Update of the RECOVER-Adult Long COVID Research Index | 2024-12-18 | 10.1001/jama.2024.24184 | Linda N. Geng | https://jamanetwork.com/journals/jama/article-abstract/2828329 | The 2024 index classified 20% of participants with known prior SARS-CoV-2 infection and 4% of those without known prior SARS-CoV-2 infection as having likely LC (vs 21% and 5%, respectively, using the 2023 index) and 39% of participants with known prior SARS-CoV-2 infection as having possible LC, which is a new category for the 2024 model. | |||||||||||||||||||||
657 | Multidisciplinary Center Care for Long COVID Syndrome–A Retrospective Cohort Study | 2024-12-18 | https://doi.org/10.1016/j.amjmed.2023.05.002 | Joseph Bailey | https://www.sciencedirect.com/science/article/pii/S0002934323003285 | Among the patients tested, 742/916 (81%) reported decreased quality of life, 284/553 (51%) had cognitive impairment, 195/434 (44.9%) had alteration of lung function, 249/299 (83.3%) had abnormal computed tomography chest scans, and 14/116 (12.1%) had elevated heart rate on rhythm monitoring. Frequency of cognitive impairment and pulmonary dysfunction was associated with severity of acute COVID-19. | |||||||||||||||||||||
658 | Impact of COVID-19 infection on thyroid functions | 2024-12-19 | https://doi.org/10.21203/rs.3.rs-5434275/v1 | hanaa S hamed | https://www.researchsquare.com/article/rs-5434275/v1 | The results indicate that thyroid dysfunction specifically hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, or subclinical hypothyroidism might be a frequent outcome for patients recovering from COVID-19, particularly in those who experienced more severe cases. Two years after discharge, only 43.4% had normal TFTs, while 10.1% were being treated for hypothyroidism and 46.5% for hyperthyroidism. | |||||||||||||||||||||
659 | Impact of SARS-CoV-2 on the male reproductive tract: insights from semen analysis and cryopreservation | 2024-12-19 | https://doi.org/10.1007/s10815-024-03321-4 | Silvia Giugliano | https://link.springer.com/article/10.1007/s10815-024-03321-4 | Our study highlights the impact of SARS-CoV-2 on male reproductive health, emphasizing the persistence of viral entry receptors, potential viral RNA presence, the inflammatory environment, and the involvement of immune populations in the male reproductive tract post-infection. Elevated inflammatory cytokines in plasma implied persistent inflammation affecting sperm vitality. | |||||||||||||||||||||
660 | Notes from the Field: Long COVID and Significant Long COVID–Associated Activity Limitation Among Adults, by Jurisdiction — United States, 2023 | 2024-12-19 | http://dx.doi.org/10.15585/mmwr.mm7350a2 | Nicole D. Ford | https://www.cdc.gov/mmwr/volumes/73/wr/mm7350a2.htm?s_cid=mm7350a2_w | In 2023, 6.4% (95% CI = 6.3–6.6%) of the noninstitutionalized U.S. adults nationwide were experiencing Long COVID when surveyed. Among adults with current Long COVID, 19.8% (95% CI = 18.9%–20.8%) reported significant activity limitations due to their symptoms. | |||||||||||||||||||||
661 | Post-COVID Condition Risk Factors and Symptom Clusters and Associations with Return to Pre-COVID Health—Results from a 2021 Multi-State Survey | 2024-12-20 | https://doi.org/10.1093/cid/ciae632 | Stacey L Konkle | https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae632/7929829?login=false | Prevalence of PCC in this population-based sample was 29·9% for persons with SARS-CoV-2 infection, during the pre-delta variant period (March–December 2020); 77·2% of persons experiencing PCC had not returned to pre-COVID health within 8–60 weeks after infection. Myalgic encephalomyelitis/chronic fatigue syndrome-like symptoms, upper-respiratory symptoms, and gastrointestinal symptoms were significantly associated with not returning to pre-COVID health. | |||||||||||||||||||||
662 | Persistence of Long COVID Symptoms Two Years After SARS-CoV-2 Infection: A Prospective Longitudinal Cohort Study | 2024-12-20 | https://doi.org/10.3390/v16121955 | Gili Joseph | https://www.mdpi.com/1999-4915/16/12/1955 | Among vaccinated adults two years after mild infection with Delta variant SARS-CoV-2, persistent symptoms attributed to Long COVID are extremely common. Weighted prevalence of persistent long COVID symptoms was 21.5%. | |||||||||||||||||||||
663 | Post-coronavirus disease 2019–associated symptoms among children and adolescents in the SARS-CoV-2 Omicron era | 2024-12-21 | https://doi.org/10.1007/s00431-024-05919-3 | Anne Schlegtendal | https://link.springer.com/article/10.1007/s00431-024-05919-3#Tab4 | Concentration disorders were reported more frequently in the COVID-19 group (12.3% versus 1.5%; p = 0.012) and “physical performance” was significantly impaired (p = 0.016) regardless of age, sex, and SARS-CoV-2 vaccination. The COVID-19 group rated their fitness as worse, with otherwise equal QoL ratings regarding general and mental health. | |||||||||||||||||||||
664 | A post-pandemic snapshot of the magnitude of COVID-19 in Brazil: A countrywide study | 2024-12-21 | https://doi.org/10.1016/j.bjid.2024.104496 | Eduardo Ribes Kohn | https://www.sciencedirect.com/science/article/pii/S1413867024007785 | Six months after the COVID-19 diagnosis, almost half the infected persons reported decreased memory and a third reported fatigue or low muscle strength amid a myriad of other debilitating complaints potentially related to the infectious disease. Memory loss was the most frequent long COVID-19 symptom, reported by 34.1 % (95 % CI 31.2–37.2) of the infected individuals. | |||||||||||||||||||||
665 | Incidence and Outcomes of Vertebral Compression Fracture Among Patients Infected with COVID-19 | 2024-12-22 | https://doi.org/10.3390/jcm13247830 | Helen Zhang | https://www.mdpi.com/2077-0383/13/24/7830 | Despite lower rates of osteoporosis, patients with a concomitant COVID-19 diagnosis exhibited a higher incidence of compression fractures. The patients with COVID-19 at the time of compression fracture diagnosis had a higher rate of vitamin D deficiency (OR: 1.25) and a lower rate of routine healing (OR: 0.61). The results of this study show that patients with COVID-19 experienced greater incidence of compression fractures, consistent with scenarios where BMD (bone mineral density) is compromised. | |||||||||||||||||||||
666 | Analysis of retinal sublayers in patients with systemic COVID-19 illness with varying degrees of severity | 2025-01-22 | https://doi.org/10.1038/s41598-025-87446-1 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11754636/ | Mohammad Reza Talebnejad | https://pubmed.ncbi.nlm.nih.gov/39843961/ | Our findings suggest that patients with severe COVID-19 illness, especially those requiring respiratory support, may develop ischemia and atrophy of the OPL (outer plexiform layer). This indicates that the OPL might be the most vulnerable retinal sublayer to systemic hypoxemia. | ||||||||||||||||||||
667 | Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors | 2024-12-23 | https://doi.org/10.1007/s00406-024-01947-0 | Yian Xiao | https://link.springer.com/article/10.1007/s00406-024-01947-0 | PTSS (post-traumatic stress symptoms) and depression remained unchanged over the two years following COVID-19 infection, while anxiety significantly decreased at the two-year mark. | |||||||||||||||||||||
668 | SARS-CoV-2 Spike S1 subunit triggers pericyte and microvascular dysfunction in human pancreatic islets | 2024-12-23 | https://doi.org/10.2337/db24-0816 | Catarina Andrade Barboza | https://diabetesjournals.org/diabetes/article/doi/10.2337/db24-0816/157642/SARS-CoV-2-Spike-S1-subunit-triggers-pericyte-and | Our findings highlight islet pericyte dysfunction as a potential contributor to the diabetogenic effects of SARS-CoV-2 and offer new insights into the mechanisms linking COVID-19, vascular dysfunction and diabetes. | |||||||||||||||||||||
669 | A Pilot Case-Control Study of Muscle and Bone Health Status in Patients Who Have Recovered From COVID-19 Infection | 2024-12-23 | 10.7759/cureus.76283 | Shital Bhor | https://www.cureus.com/articles/324014-a-pilot-case-control-study-of-muscle-and-bone-health-status-in-patients-who-have-recovered-from-covid-19-infection#!/ | Post-COVID-19 recovered female patients exhibited lower lean mass, muscle density, and handgrip strength, alongside higher body fat levels. Lean mass percentage and handgrip strength were significantly lower in post-COVID-19 recovered female patients than controls (median (IQR): 52% (48.3%) versus 64.6% (19.8%), p<0.05) and (median (IQR): 15.2 (8.4) kg versus 23.3 (14.0) kg, p<0.05). | |||||||||||||||||||||
670 | Evaluation of Vocal and Pulmonary Health Through Acoustic Analysis of Voice and Respiratory Measurements in People With Long COVID-19 Symptoms | 2024-12-24 | https://doi.org/10.1016/j.jvoice.2024.11.018 | Lok Yew Chang | https://www.jvoice.org/article/S0892-1997(24)00399-0/abstract | Significant differences in vocal acoustic and pulmonary parameters were observed between the two groups. Significant differences were found between the long COVID and control groups in several vocal acoustic parameters (F0, jitter, shimmer, CPP, MPT, and H1-H2) and pulmonary function measures (FEV1, FEV1/FVC ratio). | |||||||||||||||||||||
671 | Hearing Loss in COVID-19 Patients: An Audiological Profile of Symptomatic and Asymptomatic COVID-19 Patients in Qatar | 2024-12-24 | 10.7759/cureus.76326 | Reni K. Chandran | https://www.cureus.com/articles/321104-hearing-loss-in-covid-19-patients-an-audiological-profile-of-symptomatic-and-asymptomatic-covid-19-patients-in-qatar#!/ | Symptomatic COVID-19 patients had significant involvement of the inner ears with abnormal pure tone audiometry (PTA), extended high-frequency audiometry (EHFA), and DPOAEs compared to asymptomatic COVID-19 patients. Mean thresholds in extended high frequencies 10K-20K were higher in symptomatic patients. Abnormal distortion product otoacoustic emissions (DPOAEs) were seen in 40 (38.8%) patients; 63.3% (31/49) were symptomatic and 16.7% (9/54) were asymptomatic in 3K-8K frequencies. | |||||||||||||||||||||
672 | New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study | 2024-12-25 | https://doi.org/10.1016/j.cegh.2024.101897 | Venkatachalam Jayaseelan | https://www.sciencedirect.com/science/article/pii/S2213398424003944 | By the 3rd month, new-onset Diabetes Mellitus was significantly higher in moderate to severe COVID-19 cases. Among the study participants, the relative risk of developing Diabetes Mellitus was 2.83 (95% CI: 1.98–4.06) for the exposed group (moderate/severe cases) compared to the comparison group (mild/asymptomatic). | |||||||||||||||||||||
673 | Factors associated with quality of life in long-COVID syndrome | 2024-12-25 | DOI: 10.1097/MRR.0000000000000654 | Artemiadis, Artemios | https://journals.lww.com/intjrehabilres/abstract/9900/factors_associated_with_quality_of_life_in.115.aspx | Patients (76% female, mean age: 54.1 years) were assessed 8.7 months postinfection. Cognitive impairment, present in 49% of the sample, was not associated with QoL. In multiple linear regression, gender, fatigue, and psychological distress accounted for 42% of QoL variance. | |||||||||||||||||||||
674 | Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19 | 2024-12-26 | https://doi.org/10.3389/fmicb.2024.1470193 | Yulin Wei | https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1470193/full | Our study results indicate significant protein dysregulation and metabolic abnormalities in the plasma of Long COVID patients, leading to coagulation dysfunction, impaired energy metabolism, and chronic immune dysregulation, which are more pronounced than in COVID-19 recovered patients. Metabolomics results showed that Long COVID patients and COVID-19 recovered patients have similar metabolic disorders, mainly involving dysregulation in lipid metabolites and fatty acid metabolism. | |||||||||||||||||||||
675 | Adolescents with Persistent Symptoms Following Acute SARS-CoV-2 Infection (Long-COVID): Symptom Profile, Clustering and Follow-Up Symptom Evaluation | 2024-12-27 | https://doi.org/10.3390/children12010028 | Marco Floridia | https://www.mdpi.com/2227-9067/12/1/28 | After a mean interval of 96 days from acute infection, the mean number of symptoms (2.8 overall) was higher for pre-Omicron (3.2 vs. 2.5 in Omicron) and moderate/severe acute infections (4.2 vs. 2.7 in mild). Fatigue (62.9%) and dyspnea (43.3%) were the most common symptoms. After a mean interval of 340 days from infection, 45.3% still presented symptoms, with persistence associated with higher number of initial symptoms. | |||||||||||||||||||||
676 | Kidney Function Decline After COVID-19 Infection | 2024-12-26 | doi:10.1001/jamanetworkopen.2024.50014 | Viyaasan Mahalingasivam | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2828493 | In this cohort study of 134 565 individuals with COVID-19 and 35 987 individuals with pneumonia, there was a greater annual decline in kidney function after COVID-19 compared with after pneumonia. Findings of this study suggest an association between COVID-19 and accelerated kidney function decline, especially among people who were hospitalized | |||||||||||||||||||||
677 | Understanding the impact of COVID-19 on quality of life using surveys and Mendelian randomization | 2024-12-28 | https://doi.org/10.1038/s41598-024-81579-5 | Kexin Jiang | https://www.nature.com/articles/s41598-024-81579-5 | We found that COVID-19 have a relative increase in the risk of developing insomnia by approximately 26.7% (OR = 1.267). The results showed that among the various influences brought about by the prevalence of COVID-19, sleep disorders have a significant and widespread impact on the quality of life, especially for the elderly. | |||||||||||||||||||||
678 | The association between baseline viral load and long-term risk in patients with COVID-19 in Hong Kong: a territory-wide study | 2024-12-28 | https://doi.org/10.1038/s41598-024-65764-0 | Jasper Tromp | https://www.nature.com/articles/s41598-024-65764-0 | In a relatively mild COVID-19 population from Hong Kong, the post-acute risk of complications was substantial. During a median follow-up time of 251 (interquartile range 240–279) days, 408 (11.9%) were hospitalized for any reason and 16 (0.5%) patients died. | |||||||||||||||||||||
679 | Persistent Post-COVID-19 Olfactory Dysfunction and Its Association with Autonomic Nervous System Function: A Case-Control Study | 2024-12-28 | https://doi.org/10.3390/diseases13010004 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11765322/ | Lojine Ayoub | https://pubmed.ncbi.nlm.nih.gov/39851468/ | Significantly higher rates of ongoing smell (26.8%) and taste (14.6%) dysfunction were reported for the post-COVID-19 group compared to the control group. Post-COVID-19 patients reported 36.6 times more smell issues and 8.22 times more taste issues than controls. The findings indicated a potential link between autonomic and olfactory dysfunction. | ||||||||||||||||||||
680 | Erectile Dysfunction and Ejaculatory Dysfunction in Covid-19 Recovered Patient: Temporary or Persistent? | 2024-12-29 | https://doi.org/10.22037/uj.v21i.8113 | Exsa Hadibrata | https://pubmed.ncbi.nlm.nih.gov/39741397/ | The prevalence of Erectile Dysfunction was high in COVID-19 recovered patients. The prevalence of ED was 70% and EJD (ejaculatory dysfunction) was 2 % during 0-6 months after COVID-19 infection. | |||||||||||||||||||||
681 | Persistent Health and Cognitive Impairments Up to Four Years Post-COVID-19 in Young Students: The Impact of Virus Variants and Vaccination Timing | 2024-12-30 | https://doi.org/10.3390/biomedicines13010069 | Ashkan Latifi | https://www.mdpi.com/2227-9059/13/1/69 | Our results indicate that even in young individuals who predominantly experienced only mild forms of the infection, a gradual decline in health and fitness can occur over a span of four years post-infection. Notably, some negative trends—at least in men—only began to stabilize or even reverse during the fourth year, whereas in women, these trends showed no such improvement. | |||||||||||||||||||||
682 | Post-COVID-19 manifestations among college students: shedding the light on young adults’ health | 2024-12-30 | https://doi.org/10.1186/s12889-024-20925-8 | Areej Abed Alkhormani | https://link.springer.com/article/10.1186/s12889-024-20925-8 | 16.8% of the patient were included in the prolonged group, and approximately two thirds of those in this group continued to experience at least two symptoms. The persistent group accounted for 6.8%, and three quarters of the patients had at least two symptoms after the COVID-19 incubation period. The PHQ-9 score when comparing the three groups showed a significant association with depression (p = 0.035). | |||||||||||||||||||||
683 | Lung long distance: histopathological changes in lung tissue after COVID-19 pneumonia | 2024-12-30 | https://doi.org/10.3325/cmj.2024.65.501 | PMC11748447 | Grgur Salai | https://pmc.ncbi.nlm.nih.gov/articles/PMC11748447/ | Our study observed a slow recovery of lung tissue with long-lasting DAD and VA, likely followed by interstitial inflammation or focal fibrosis. DAD (diffuse alveolar damage) with VA (vascular abnormalities) was detected up to the 9th week from the onset of disease; inflammatory pattern from the 8th to 28th week (4 patients with this pattern biopsied in the 11th-13th week had accompanying VA); and a predominantly fibrotic pattern was found at weeks 8, 10, 48, and 49. | ||||||||||||||||||||
684 | New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx | 2024-12-30 | https://doi.org/10.1038/s41598-024-83232-7 | Sagar Changela | https://link.springer.com/article/10.1038/s41598-024-83232-7 | This study investigated the incidence of new GID and identified risk factors contributing to the development of these disorders up to 3.5 years post-infection. We found that 6.34% (2,228) of COVID-19-positive patients developed new GI disorders, compared to 5.70% (38,928) of controls, with COVID-19 patients being more likely to develop new GI disorders than matched controls (adjusted HR = 1.18, 95% CI [1.12–1.25]). | |||||||||||||||||||||
685 | Post–COVID-19 Mental Health Distress in 13 Million Youth: A Retrospective Cohort Study of Electronic Health Records | 2024-12-30 | https://doi.org/10.1016/j.jaac.2024.03.023 | Yanli Zhang-James | https://www.sciencedirect.com/science/article/abs/pii/S0890856724002636 | Within 2 years post SARS-CoV-2 infection, children had a probability of 0.15 in acquiring new psychiatric diagnoses, compared to 0.026 for matched non-infected children; adolescents had a 0.19 probability against 0.05 for their non-infected counterparts. The hazard ratio (HR) was 6.0 (95% CI = 5.8-6.3) for children and 4.2 for adolescents (95% CI = 4.1-4.4). | |||||||||||||||||||||
686 | Long-term consequences of COVID-19 on mental and physical health in young adults | 2024-12-30 | https://doi.org/10.21101/cejph.a8118 | Darina Falbová | https://cejph.szu.cz/artkey/cjp-202404-0001_long-term-consequences-of-covid-19-on-mental-and-physical-health-in-young-adults.php | Significant effects of COVID-19 on mental and physical health were found. These effects demonstrate that COVID-19 has had a negative impact on the long-term health and quality of life of young adults. The statistically significant effect of COVID-19 after recovery on adverse cognitive health was only documented in women in the following symptoms: memory deterioration (p < 0.001), problems with concentration (p < 0.001), difficulty in handling tasks requiring thinking, planning and problem-solving (p < 0.001), and problems with finding the correct words in their expressions (p = 0.001). The prevalence of these symptoms was higher in women after the COVID-19 recovery than before. Participants also reported the most pronounced long-term changes in the following physiological symptoms: decreased physical fitness (p < 0.001 for women and men) and headaches (p < 0.001 for women). | |||||||||||||||||||||
687 | Epidemiological insights into chronic urticaria, vitiligo, alopecia areata, and herpes zoster following COVID-19 infection: A nationwide population-based study | 2024-12-31 | https://doi.org/10.1111/1346-8138.17600 | Min Hee Kim | https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.17600 | Chronic urticaria, vitiligo, alopecia areata, and herpes zoster manifested at higher rates within the COVID-19 cohort, even after multivariable adjustment for potential confounders. COVID-19 may increase the risk of developing chronic urticaria, vitiligo, alopecia areata, and herpes zoster. | |||||||||||||||||||||
688 | COVID-19 infection and later risk of sickness absence by socioeconomic status: a cohort study | 2024-12-31 | https://doi.org/10.1186/s12889-024-21148-7 | Matti Joensuu | https://link.springer.com/article/10.1186/s12889-024-21148-7 | A self-reported COVID-19 infection in 2020 was associated with higher subsequent risk of sickness absence in 2021: Adjusted Incidence Rate Ratio (IRR) compared to those not reporting COVID-19 was 1.23, 95% confidence interval (CI) 1.10–1.37 for sickness absence days, 1.29, 1.20–1.38 for short sickness absence spells and 1.20, 1.04–1.37 for long spells. | |||||||||||||||||||||
689 | Evaluation of the long-term effects of COVID-19 on pulmonary functions in recovered patients | 2024-12-31 | DOI: 10.4103/jfmpc.jfmpc_2034_23 | Naja, K | https://journals.lww.com/jfmpc/fulltext/2024/13120/evaluation_of_the_long_term_effects_of_covid_19_on.14.aspx | Patients with COVID-19 pneumonia, which required oxygen, especially severe disease at the time of hospitalization, had a higher rate of abnormal spirometry than patients with mild symptoms. Follow-up CT scans obtained within six months of disease onset showed abnormalities in more than half of patients, particularly elderly patients. | |||||||||||||||||||||
690 | Evaluation of long-term pulmonary functions after COVID-19 infection in children: a longitudinal observational cohort study | 2024-12-31 | https://doi.org/10.3855/jidc.20123 | Muhammet F Korkmaz | https://www.jidc.org/index.php/journal/article/view/39863942 | Among the children hospitalized due to COVID-19 infection in our center, we encountered ongoing respiratory symptoms in 41% of patients during our outpatient follow-up, and abnormal pulmonary functions in 24% of them | |||||||||||||||||||||
691 | Widening the scope for the burden of COVID-19 - Comorbidities and long COVID: an analysis of the three pandemic years in Luxembourg | 2025-01-01 | https://doi.org/10.26355/eurrev_202501_37058 | S. Schmitz | https://pubmed.ncbi.nlm.nih.gov/39911045/ | The COVID-19 pandemic has produced a significant burden on the resident population in Luxembourg. The total burden of COVID-19, including PAC (post-acute consequences), over three years, was estimated at 17,801 DALYs (disability-adjusted life years), combining 14,903 YLLs and 2,898 YLDs (Years of Healthy Life lived with Disability). | |||||||||||||||||||||
692 | Acoustic Characteristics of Voice and Speech in Post-COVID-19 | 2025-01-01 | https://doi.org/10.3390/healthcare13010063 | Larissa Cristina Berti | https://pmc.ncbi.nlm.nih.gov/articles/PMC11719735/ | Regarding the acoustic characteristics of voice, jitter, shimmer, and HNR, significant differences between the groups were found. Some acoustic characteristics of the patients’ voice may show a deteriorated condition even after exacerbation of the disease. These characteristics are compatible with some of the symptoms reported by post-COVID-19 | |||||||||||||||||||||
693 | Long-Haul COVID: Investigating the Effects Within the Mauritian Context | 2025-01-02 | https://doi.org/10.3390/covid5010006 | Aïsha B. Soreefan | https://www.mdpi.com/2673-8112/5/1/6 | Long COVID manifests as a complex and long-lasting affliction that affects even young adults with disabling outcomes, owing to multiple lingering symptoms but, most importantly, fatigue. Of 285 Mauritians with a confirmed history of COVID-19 infection, 64.2% developed Long COVID. The most prevalent symptoms were fatigue or muscle weakness (88.0%), cough (57.4%), difficulty concentrating (55.2%), trouble remembering or memorising (49.7%), insomnia or sleep disturbance (43.7%), amongst others. | |||||||||||||||||||||
694 | Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study | 2025-01-02 | https://doi.org/10.1038/s41598-024-84598-4 | Daya Zhang | https://www.nature.com/articles/s41598-024-84598-4 | While most individuals infected with COVID-19 fully recover, approximately 12.5% experience intermediate or long-term effects. The most common symptoms were cough (33.3%, 40/120), followed by fatigue (25.9%, 31/120), hair loss (23.3%, 28/120), and dizziness (20.8%, 25/120). Independent risk factors included age over 65, moderate to severe infection, chronic diseases, irregular diet, late sleeping, anxiety, and fewer than 2 vaccinations (p < 0.05). | |||||||||||||||||||||
695 | Infectious agents in the pathogenesis of autoimmune rheumatic diseases | 2025-01-02 | https://doi.org/10.1016/j.trsl.2024.12.004 | Aleksandra Korzeniowska | https://www.sciencedirect.com/science/article/pii/S1931524424002007 | In about 10 %−30 % of non-hospitalized patients after the infection can be observed the so-called long COVID. Moreover the risk of long COVID development increases among hospitalized patients even up to 70 %. Long COVID symptoms are multisystem, including outcomes of cardiovascular, thrombotic, cerebrovascular conditions, type 2 diabetes, and postural orthostatic tachycardia syndrome (POTS). | |||||||||||||||||||||
696 | Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative | 2025-01-02 | https://doi.org/10.1016/j.eclinm.2024.103042 | Suchitra Rao | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00621-7/fulltext | Children <5 years (Odds Ratio [OR] 1.78, 95% CI 1.62–1.97), and of Hispanic White descent (OR 1.19, 95% CI 1.05–1.35) had higher odds of having respiratory PASC. In contrast, older (OR 1.57, 95% CI 1.40–1.77 for those aged 12–17 years), non-Hispanic White individuals and those with chronic pre-existing neurologic conditions (OR 2.04, 95% CI 1.78–2.35) were more likely to have a neurologic PASC diagnosis. | |||||||||||||||||||||
697 | Demographic and clinical factors associated with functional changes in Long-Covid | 2025-01-03 | 10.1097/PHM.0000000000002686 | Mazer, Barbara | https://journals.lww.com/ajpmr/abstract/9900/demographic_and_clinical_factors_associated_with.657.aspx | 37.8% were classified as having Long-Covid based on the positive response to “Are you still troubled by symptoms?”. The majority of them reported a decline in global health, mobility, and participation in daily activities. Common changes in function included fatigue, breathlessness upon climbing stairs and when dressing, decline in participation in usual activities, anxiety, pain/discomfort, and reduced concentration. | |||||||||||||||||||||
698 | Mortality for Post COVID Condition: 2025 Update | 2025-01-03 | doi: 10.20944/preprints202501.0224.v1 | Giuseppe Lippi | https://www.preprints.org/manuscript/202501.0224/v1 | These findings underscore the significant yet nuanced impact of post-COVID condition on mortality. By December 2024, 2,653 US deaths were classified under the ICD-10 code U09.9, corresponding to an age-adjusted mortality rate of 0.089×100,000. | |||||||||||||||||||||
699 | Prevalence and risk factors for long COVID in China: a systematic review and meta-analysis of observational studies | 2025-01-04 | https://doi.org/10.1016/j.jiph.2025.102652 | Le-Yan Hu | https://www.sciencedirect.com/science/article/pii/S1876034125000012 | Current systematic review found that nearly half of COVID-19 patients may suffering from long COVID in China. The three most common symptoms of long COVID were fatigue (0.33, 95%CI 0.28 to 0.39), cognitive decline (0.30, 95%CI 0.14 to 0.46) and shortness of breath (0.29, 95%CI 0.15 to 0.43). | |||||||||||||||||||||
700 | Impact of COVID-19 Diagnosis on Weight Trajectories of Children in the US National COVID Cohort Collaborative | 2025-01-05 | https://doi.org/10.1101/2025.01.03.25319927 | Md Mozaharul Mottalib | https://www.medrxiv.org/content/10.1101/2025.01.03.25319927v1 | Having a COVID-19 diagnosis was associated with more rapid weight gain, especially after diagnosis and early in the pandemic. COVID-19 positive patients had a greater increase in %BMI_p95 than COVID-19 negative patients (average increase of 2.34 (+/-7.73) compared to 1.46 (+/-6.09), p<0.0005). COVID-19 positive patients gained more weight after their diagnosis of COVID-19 than before. | |||||||||||||||||||||
701 | Prevalence of and factors associated with long COVID among diverse healthcare workers in the UK: a cross-sectional analysis of a nationwide study (UK-REACH) | 2025-01-06 | doi: 10.1136/bmjopen-2024-086578 | Amani Al-Oraibi | https://bmjopen.bmj.com/content/15/1/e086578 | we found that 2331 (20.25%) reported COVID-19, of whom 525 (22.52%) experienced long COVID. The majority of those experiencing long COVID were female (80.0%) and were slightly older than those who did not experience long COVID (median age 46 (IQR 36–54)) | |||||||||||||||||||||
702 | Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis | 2025-01-06 | https://doi.org/10.1101/2025.01.01.24319384 | Yiren Hou | https://www.medrxiv.org/content/10.1101/2025.01.01.24319384v1 | The prevalence of long COVID persists over extended follow-up, with a high burden of symptoms 1 to 2 years post-infection. In our meta-analysis, the prevalence of long COVID remained consistent irrespective of time since diagnosis, with 35% at less than 1 year follow-up and 47% at one to two years, suggesting a sustained burden of symptoms without a decrease over longer follow-up durations. | |||||||||||||||||||||
703 | SARS-CoV-2 Productively Infects Human Hepatocytes and Induces Cell Death | 2025-01-06 | https://doi.org/10.1002/jmv.70156 | Chunkyu Ko | https://onlinelibrary.wiley.com/doi/10.1002/jmv.70156 | SARS-CoV-2 infection rapidly induced hepatocyte death in a replication-dependent fashion, with the Omicron variant showing faster onset but less extensive cell death. Liver histology revealed profound tissue damage and immune cell infiltration, indicating that direct cytopathic effects of SARS-CoV-2 and immune-mediated killing of infected hepatocytes contribute to liver pathology. | |||||||||||||||||||||
704 | Early prediction of long COVID-19 syndrome persistence at 12 months after hospitalisation: a prospective observational study from Ukraine | 2025-01-06 | doi: 10.1136/bmjopen-2024-084311 | Oleksii Honchar | https://bmjopen.bmj.com/content/15/1/e084311 | Self-reported LCS was detected in 76% of participants at 3 months and in 43% at 12 months after discharge. | |||||||||||||||||||||
705 | Exploring Medium- and Long-Term Respiratory and Functional Sequelae in Young Adults Post-COVID-19 | 2025-01-07 | https://doi.org/10.3390/medicina61010086 | Büşra Ülker Ekşi | https://www.mdpi.com/1648-9144/61/1/86 | Young adults who pass asymptomatic or mild SARS-CoV-2 infection exhibit a decline in FVC%pred, PEF%pred, lower extremity muscle performance, and physical function within 3–6 months. In addition, the deterioration in respiratory and physical functions becomes apparent within 6–12 months. | |||||||||||||||||||||
706 | Tracking Survivors With Long COVID: Method, Implementation, and Results of an Observational Study | 2025-01-07 | https://doi.org/10.1002/nur.22437 | Horng-Shiuann Wu | https://onlinelibrary.wiley.com/doi/10.1002/nur.22437 | The findings showed that 66% of the 2020−2021 cohort and 47% of the 2021−2022 cohort reported ≥ 1 lingering symptom with an average of 11.2 (±3.0) and 8.9 (±3.3) months, respectively, after COVID-19 diagnosis. Our analyses showed that a moderate proportion (43%) of adults remained symptomatic nearly a year after COVID-19 infection and time since diagnosis did not affect symptom experience in either cohort. | |||||||||||||||||||||
707 | Post-COVID symptoms after SARS-CoV-2 omicron infection and the effect of booster vaccination: A population-based cohort study | 2025-01-08 | https://doi.org/10.1016/j.vaccine.2024.126664 | Ida Henriette Caspersen | https://www.sciencedirect.com/science/article/pii/S0264410X2401346X | Among those with two doses only, the excess risk for new symptoms after infection (vs. no infection) were up to 15 % for women and 9 % for men. Among infected subjects with recent booster dose, the corresponding excess risks were 7 % among women and up to 5 % among men.Although lower than for earlier variants, the excess risks of symptoms at 3–5 months were, in the context of the high population prevalence of infection, substantial for infected individuals overall. | |||||||||||||||||||||
708 | Effects of sleep quality on the risk of various long COVID symptoms among older adults following infection: an observational study | 2025-01-09 | https://doi.org/10.1186/s12877-025-05675-5 | Min Du | https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-025-05675-5 | The prevalence of long COVID among older adults was 57.4% (2,743/4,781). Specifically, the prevalence of general symptoms, cardiovascular symptoms, respiratory symptoms, gastrointestinal symptoms, and neurological and psychiatric symptoms was 47.7% (2,282/4,781), 3.4% (163/4,781), 35.2% (1683/4,781), 8.7% (416/4,781) and 5.8% (279/4,781), respectively. | |||||||||||||||||||||
709 | Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19 | 2025-01-10 | https://doi.org/10.1007/s10565-024-09976-0 | Irene Gómez-Delgado | https://link.springer.com/article/10.1007/s10565-024-09976-0 | Long after acute infection, mitochondrial and metabolic changes seem to differ in a situation of full recovery after mild infection versus the one evolving from severe infection. The observed enduring changes in metabolism and energy balance upon COVID-19 might suggest important subclinical drivers of future disease under stress conditions. | |||||||||||||||||||||
710 | Acute kidney injury in critically ill COVID-19 patients in a tertiary hospital: short and long-term kidney and patient outcomes | 2025-01-10 | https://doi.org/10.1590/2175-8239-JBN-2024-0107en | PMC11726861 | Juliana Alves Manhães de Andrade | https://pmc.ncbi.nlm.nih.gov/articles/PMC11726861/ | Critically ill COVID-19 patients with NC-AKI presented a high frequency of AKI stage 3 and KRT requirement, with a high 90-day mortality. Surviving patients had high rates of recovery of kidney function, with a lower eGFR at one-year follow-up compared to baseline. At 1 year, mortality was 89.3%. Amongst surviving patients, 72% recovered kidney function, although with significantly lower eGFR compared to baseline. | ||||||||||||||||||||
711 | Vimentin as a contributing factor in SARS-CoV-2-induced orchitis on postmortem testicular autopsy of COVID-19 cases: A case-control study | 2024-01-10 | https://doi.org/10.18502/ijrm.v22i11.17822 | Soheila Akaberi-Nasrabadi | https://pmc.ncbi.nlm.nih.gov/articles/PMC11757669/ | There may be a strong link between vimentin expression and COVID-19-induced orchitis. Gene expression analysis revealed increased expression of vimentin and decreased expression of the proliferation markers Ki67 and proliferating cell nuclear antigen, suggesting that SARS-CoV-2 may disrupt spermatogenesis through immune responses and the arrest of cell proliferation. | |||||||||||||||||||||
712 | Prevalence and symptoms of Long Covid-19 in the workplace | 2025-01-11 | https://doi.org/10.1093/occmed/kqae128 | H Mohd Yusoff | https://academic.oup.com/occmed/advance-article/doi/10.1093/occmed/kqae128/7952809?login=false | There were 43 symptoms associated with Long Covid-19 in the workplace. The prevalence of Long Covid-19 among workers was 38%. Common symptoms include dyspnoea, mental disorders, fatigue and effort intolerance. Workers with Long Covid-19 often report decreased work productivity due to persistent symptoms. There is a higher rate of sickness absenteeism as workers manage ongoing health issues. Employers may suffer a rise in healthcare costs due to the long-term medical needs of workers affected by Long Covid-19. | |||||||||||||||||||||
713 | Post COVID-19 and Long COVID Symptoms in Otorhinolaryngology—A Narrative Review | 2025-01-14 | https://doi.org/10.3390/jcm14020506 | Orlando Guntinas-Lichius | https://www.mdpi.com/2077-0383/14/2/506 | Otorhinolaryngological Post/Long COVID symptoms have a high prevalence worldwide among both children and adults. The confirmed prevalence estimated for anosmia, dysgeusia, cough, facial palsy, hoarseness/dysphonia, acute hearing loss, tinnitus, and vertigo/dizziness was about 4%, 2%, 4–19%, 0%, 17–20%, 8%, 20%, and 5–26%, respectively. Otorhinolaryngological symptoms did not appear isolated but as part of a multi-organ syndrome. | |||||||||||||||||||||
714 | Dysphonia and COVID-19: A Review | 2025-01-14 | https://doi.org/10.1016/j.jvoice.2024.11.034 | Regina Helena Garcia Martins | https://www.sciencedirect.com/science/article/abs/pii/S0892199724004193 | Dysphonia caused by COVID-19 infection is common, both in the acute and chronic phases of the disease. The main causes include vocal fold paralysis, inflammatory laryngitis, and muscle tension dysphonia. | |||||||||||||||||||||
715 | Post‑COVID syndrome in children compared with adults (Review) | 2025-01-15 | https://doi.org/10.3892/wasj.2025.314 | Helena C. Maltezou | https://www.spandidos-publications.com/10.3892/wasj.2025.314/abstract | The present research revealed that almost one quarter of children and adolescents with COVID‑19 develop long‑COVID symptoms after recovery from their illness or discharge from hospital. Nevertheless, some symptoms may persist for >1 year, which may impact their social and educational activities and overall well‑being. | |||||||||||||||||||||
716 | Tracking Persistent Symptoms in Scotland (TraPSS): a longitudinal prospective cohort study of COVID-19 recovery after mild acute infection | 2025-01-15 | https://doi.org/10.1136/bmjopen-2024-086646 | Nicholas F Sculthorpe | https://bmjopen.bmj.com/content/15/1/e086646 | In conclusion, around a third of individuals had no, or limited, symptoms following infection with COVID-19. Of those with symptoms, most recovered over the subsequent months, often much more slowly than from other viral infections. A small proportion (~3%) had ongoing symptoms at the end of the 9-month follow-up. | |||||||||||||||||||||
717 | Attributes and factors associated with long covid in patients hospitalized for acute COVID-19: A retrospective cohort study | 2025-01-16 | https://doi.org/10.1371/journal.pone.0317512 | Bethlehem Berhanu Minassie | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0317512 | There is a high prevalence of Long COVID among patients hospitalized for acute COVID-19. One hundred seventy-eight (72.1%) participants had at least one persisting symptom 4 weeks post-symptom onset, at a median follow-up time of 35 (IQR 32–40) days. The most frequently reported symptoms were fatigue (41.7%), shortness of breath (31.2%), cough (27.1%), and sleep disturbances (15%). | |||||||||||||||||||||
718 | Change in exacerbation rate of COPD patients before and after COVID-19 infection | 2025-01-18 | https://doi.org/10.1038/s41598-025-86426-9 | Joon Young Choi | https://www.nature.com/articles/s41598-025-86426-9 | COVID-19 infection resulted in increased annual moderate-to-severe and severe exacerbations compared to pre-COVID-19 infection (IRR = 1.062; IRR = 1.315, respectively). Among previously non-exacerbators, 11.2% of patients transitioned to exacerbator after COVID-19 infection. Direct medical costs escalated significantly from approximately $6810 to $11,032, reflecting the increased intensity of care after COVID-19 infection. | |||||||||||||||||||||
719 | Long-term Mental Health Morbidity in Adult Survivors of COVID-19 Critical Illness - A Population-based Cohort Study | 2025-01-21 | https://doi.org/10.1016/j.chest.2025.01.012 | Shannon M Fernando | https://pubmed.ncbi.nlm.nih.gov/39848569/ | As compared to survival after critical illness from non-COVID-19 pneumonia, survival after COVID-19 critical illness was not associated with increased risk of the composite outcome of new mental health diagnosis, but was associated with elevated risk for new mood, anxiety, or related disorders. COVID-19 critical illness was not associated with increased risk of new mental health diagnosis overall (hazard ratio [HR] 1.08 [95% CI: 0.96-1.23]), but was associated with increased risk in the category of new mood, anxiety, or related disorders (HR 1.21 [95% CI: 1.05-1.40]). | |||||||||||||||||||||
720 | SARS-CoV-2 Impairs Osteoblast Differentiation Through Spike Glycoprotein and Cytokine Dysregulation | 2025-01-22 | https://doi.org/10.3390/v17020143 | Rosa Nicole Freiberger | https://www.mdpi.com/1999-4915/17/2/143 | This study highlights the capacity of ancestral and Omicron SARS-CoV-2 variants to disrupt osteoblast differentiation, a process essential for preserving the homeostasis and functionality of bone tissue. The upregulation of receptor activator of nuclear factor kappa B ligand (RANKL) strongly suggests that the ancestral and Omicron variants may disrupt bone homeostasis by promoting osteoclast differentiation, ultimately leading to the formation of bone-resorbing cells. | |||||||||||||||||||||
721 | Analysis of retinal sublayers in patients with systemic COVID-19 illness with varying degrees of severity | 2025-01-22 | https://doi.org/10.1038/s41598-025-87446-1 | Mohammad Reza Talebnejad | https://www.nature.com/articles/s41598-025-87446-1 | Patients with severe COVID-19 illness, especially those requiring respiratory support, may develop ischemia and atrophy of the OPL (outer plexiform layer). he observed OPL atrophy may have clinical implications, including potential impacts on fine visual tasks, such as contrast sensitivity, color vision, and edge detection. | |||||||||||||||||||||
722 | Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study | 2025-01-23 | https://doi.org/10.1371/journal.pmed.1004511 | Raphael S. Peter | https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004511 | In this study, we observed that the majority of working age patients with PCS did not recover in the second year of their illness. Patterns of reported symptoms remained essentially similar, non-specific and dominated by fatigue, exercise intolerance and cognitive complaints. We found that two-thirds of the individuals with PCS had persisting disease for more than a year with no major changes in symptom clusters. | |||||||||||||||||||||
723 | Self-Reported Post-COVID Symptoms at 18 Months After Infection Among Adults in Southern Brazil: A Cross-Sectional Study | 2025-01-23 | https://doi.org/10.3390/healthcare13030228 | Franciele Aline Machado de Brito | https://www.mdpi.com/2227-9032/13/3/228 | In the 18 month follow-up, the main persistent symptoms were memory loss (42.7%), fatigue (32.2%), anxiety (23.5%), dyspnea (19.7%), and hair loss (19.7%). Long COVID is a complex condition that requires long-term monitoring and investment in health services due to its high prevalence and the health consequences in the population. | |||||||||||||||||||||
724 | Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort | 2025-01-23 | https://doi.org/10.1038/s41598-024-84140-6 | Jakob Höppner | https://link.springer.com/article/10.1038/s41598-024-84140-6 | After infection, PCS-like symptoms persisted in 7% of the respondents for more than three months and up to four years. | |||||||||||||||||||||
725 | Adaptation of the WHO COVID-19 Clinical Progression Scale for Registry-Based Data: A Whole-Population Study in Sweden | 2025-01-23 | https://dx.doi.org/10.2139/ssrn.5100756 | Hanna Jerndal | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5100756 | Among survivors beyond the first month, 90-day all-cause mortality increased with initial severity using category zero (no laboratory-verified positive SARS-CoV-2 test) as the reference category. Those hospitalised over five days had higher mortality (7·89, 7·43–8·36); and those requiring ECMO/ECLS had the highest mortality (671·53, 332·83–1354·90). COVID-19 survivors that did not initially require specialised healthcare still had a two-fold increased risk of all-cause mortality compared to the population, despite adjusting for age, elderly care, comorbidities and other covariates. | |||||||||||||||||||||
726 | Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls | 2025-01-24 | https://doi.org/10.1038/s41390-025-03837-0 | Danilo Buonsenso | https://www.nature.com/articles/s41390-025-03837-0 | Pediatric Long COVID patients have a well distinct blood protein signature marked by increased ongoing general and endothelial inflammation, similarly as happens in adults. Compared with controls, pediatric Long COVID was characterized by higher expression of the proinflammatory and pro-angiogenetic set of chemokines CXCL11, CXCL1, CXCL5, CXCL6, CXCL8, TNFSF11, OSM, STAMBP1a. | |||||||||||||||||||||
727 | The rise in incidence of pediatric type 2 diabetes during the COVID-19 pandemic and the virus as a potential causative factor | 2025-01-24 | https://doi.org/10.1016/j.deman.2025.100258 | Andrew Kanouse | https://www.sciencedirect.com/science/article/pii/S2666970625000071 | Our data showed an increase in the incidence of type 2 diabetes (p<0.0001) and a lower mean presenting age (p=0.03) during the COVID-19 pandemic without differences in other parameters. We believe these results suggest that the development of type 2 diabetes following COVID-19 infection is due to mechanisms inherent to the virus itself and that younger patients are especially at an increased risk. | |||||||||||||||||||||
728 | Consequences of COVID-19 for geriatric patients during a pandemic | 2025-01-24 | https://doi.org/10.1038/s41598-024-84379-z | Ludwig Wemhöner | https://www.nature.com/articles/s41598-024-84379-z | Results showed that the mortality in this vulnerable group was 52% (n = 209). It is worth noting that nearly half of the geriatric patients had succumbed to the disease one year later. This represents a substantial increase in excess mortality within these age groups. | |||||||||||||||||||||
729 | Prevalence and severity of anxiety, stress, and depression in long COVID among adults in Barcelona | 2025-01-24 | https://doi.org/10.3399/BJGPO.2024.0098 | Brenda Biaani León-Gómez | https://bjgpopen.org/content/early/2025/01/23/BJGPO.2024.0098.1 | Severe' stress and 'Extremely Severe' anxiety were prevalent in the sample. Our study highlights the significant mental health burden in LC patients, underscoring the need for targeted interventions, especially among adults over 45 years old and non-healthcare workers. | |||||||||||||||||||||
730 | Prevalence of and risk factors for long COVID following infection with the COVID‑19 omicron variant | 2025-01-24 | https://doi.org/10.3892/mi.2025.216 | PMC11803340 | Isao Moritani | https://pmc.ncbi.nlm.nih.gov/articles/PMC11803340/ | On the whole, the present study demonstrates that the incidence of LC was >10% even in the omicron group. The percentages of patients in whom some type of symptom or sequelae continued after 1, 3 and 6 months were 44, 37 and 28%, respectively, in the pre-omicron group, and 20, 12 and 9%, respectively, in the omicron group. | ||||||||||||||||||||
731 | Exploring Hypercoagulability in Post-COVID Syndrome (PCS): An Attempt at Unraveling the Endothelial Dysfunction | 2025-01-25 | https://doi.org/10.3390/jcm14030789 | Maxim Muys | https://www.mdpi.com/2077-0383/14/3/789 | Patients with PCS show a consistent pattern of prolonged thrombo-inflammatory dysregulation, highlighted by elevated in vitro thrombin generation and the persistence of abnormal VWF/ADAMTS-13 ratios in a subset of patients. Although most PCS patients showed normalized VWF/ADAMTS13 ratios, 11.3% exhibited elevated ratios (≥1.5), associated with advanced age. | |||||||||||||||||||||
732 | Longitudinal Assessment of Pulmonary Involvement and Prognosis in Different Subtypes of COVID-19 Patients After One Year Using Low-Dose CT: A Prospective Observational Study | 2025-01-25 | https://doi.org/10.1016/j.acra.2025.01.006 | Jinyang Zhao | https://www.sciencedirect.com/science/article/abs/pii/S1076633225000054 | One year after infection, more than one third of even moderate patients with mild symptoms had persistent pulmonary abnormalities. In our study, fibrotic changes were seen in severe and critically ill patients and remained stable 6 months after discharge from hospital. After 1 year, 34.38% (22/64) of patients still had abnormal lung function, and 9.38% (6/64) had pulmonary fibrosis and restrictive ventilatory dysfunction. | |||||||||||||||||||||
733 | SARS-CoV-2 Infection and the Risk of New Chronic Conditions: Insights from a Longitudinal Population-Based Study | 2025-01-26 | https://doi.org/10.3390/ijerph22020166 | David De Ridder | https://www.mdpi.com/1660-4601/22/2/166 | Participants reporting a SARS-CoV-2 infection were more likely to be diagnosed with a new chronic condition compared to those who did not report an infection (adjusted odds ratio [aOR] = 2.15, 95% CI 1.43–3.23, adjusted p-value = 0.002). | |||||||||||||||||||||
734 | Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study | 2025-01-27 | https://doi.org/10.1038/s41598-024-80833-0 | Rajish S. K. Shil | https://link.springer.com/article/10.1038/s41598-024-80833-0 | We identified that those who developed a neurological or psychiatric complication of COVID-19 were more likely to have a poor outcome at follow-up at median interval of more than 12 months after hospital discharge. A higher proportion of cases had impairment in ADLs (activity of daily living) (OR 2.06, p < 0.0002) and reported symptoms impacting employment (OR 2.53, p < 0.0001). | |||||||||||||||||||||
735 | Digital health app data reveals an effect of ovarian hormones on long COVID and myalgic encephalomyelitis symptoms | 2025-01-27 | https://doi.org/10.1101/2025.01.24.25321092 | Abigail Goodship | https://www.medrxiv.org/content/10.1101/2025.01.24.25321092v1 | Menstruation is associated with worsened symptoms in long COVID and ME/CFS. Crashes (sudden and severe worsening of symptoms following exertion) were significantly more frequent during menstruation than in other phases. | |||||||||||||||||||||
736 | Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus | 2025-01-27 | doi:10.1001/jamainternmed.2024.7452 | Kristina L. Bajema | https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2829342 | COVID-19 was associated with more severe disease outcomes, including long-term mortality, compared with influenza or RSV. RSV was associated with lower 30-day risk of hospitalization, and COVID-19 was associated with a higher risk of long-term mortality through 180 days. | |||||||||||||||||||||
737 | Predictors of Post-Acute Sequelae of COVID-19 in a Diverse Urban Population | 2025-01-27 | https://doi.org/10.1007/s11606-025-09383-z | https://link.springer.com/article/10.1007/s11606-025-09383-z | https://link.springer.com/article/10.1007/s11606-025-09383-z | This study reveals a high prevalence of PASC 1 year post-infection, with notable racial and ethnic disparities. In total, 54.1% of those diagnosed with COVID-19 reported PASC symptoms 1 year after infection. Racial and ethnic disparities in the prevalence of PASC varied by PASC phenotype and by the time of initial diagnosis (Wave 1 versus Wave 2) (March to July 2020 and January to March 2021). | |||||||||||||||||||||
738 | Differences in clinical characteristics between coronavirus disease 2019 (COVID-19) and influenza: a systematic review and meta-analysis | 2025-01-28 | https://doi.org/10.1038/s41533-025-00414-0 | Yingying Han | https://www.nature.com/articles/s41533-025-00414-0 | (Compared to influenza patients), COVID-19 patients often require more medical resources and have worse clinical outcomes. Patients with COVID-19 had longer stays in the hospital (MD = 3.20, 95% CI: 2.58–3.82) and ICU (MD = 3.10, 95% CI: 1.44–4.76), required mechanical ventilation more frequently (OR = 2.30, 95% CI: 1.77–3.00), and had higher mortality (OR = 2.22, 95% CI: 1.93–2.55). | |||||||||||||||||||||
739 | SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells | 2025-01-28 | https://doi.org/10.1038/s41598-025-86242-1 | Katie V. Tieu | https://www.nature.com/articles/s41598-025-86242-1 | We observed that endothelial cells are suitable host cells for SARS-CoV-2 viral infection and replication, and that viral infection also causes syncytia formation. Our studies indicate that endothelial cells, in addition to epithelial cells, should also be considered a target for SARS-CoV-2 infection and a driver of COVID-19-associated pathology. | |||||||||||||||||||||
740 | Prevalence of depression, anxiety, stress, and suicide tendency among individual with long-COVID and determinants: A systematic review and meta-analysis | 2025-01-28 | https://doi.org/10.1371/journal.pone.0312351 | Razieh Bidhendi-Yarandi | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312351 | One-fourth of individual with long-COVID experience mental health symptoms, including depression, anxiety, and stress, which remain prevalent even two years post-infection despite a slight decreasing trend. The high prevalence of these issues after two years suggests that many individuals continue to experience substantial psychological distress long after their initial COVID-19 infection. | |||||||||||||||||||||
741 | Post COVID-19 infection and quality of life of healthcare workers at Sahloul University Hospital of Sousse in Tunisia | 2025-01-29 | https://doi.org/10.1007/s11136-024-03878-8 | Amene Fki | https://link.springer.com/article/10.1007/s11136-024-03878-8 | Post covid-19 syndrome was reported in 65% of cases. A low overall quality of life (QoL) score was reported in 28.6% of cases. Low physical and mental composite scores were reported in 34.3% and 29.4% of cases respectively. In the multiple linear regression analysis, gender, post COVID-19 syndrome and time off work were significantly associated with SF12 scores. | |||||||||||||||||||||
742 | The hospital and mortality burden of COVID-19 compared with influenza in Denmark: a national observational cohort study, 2022–24 | 2025-01-29 | https://doi.org/10.1016/S1473-3099(24)00806-5 | Peter Bager | https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00806-5/fulltext | COVID-19 represented a greater disease burden than influenza, with more hospital admissions and deaths, and more severe disease (primarily among non-vaccinated people, those with comorbidities, and male patients).The number of deaths was also higher for patients with COVID-19 (n=2361) than patients with influenza (n=489, aIRR 3·19). | |||||||||||||||||||||
743 | Physical impairments in individuals with Long COVID | 2025-01-29 | https://doi.org/10.3389/fspor.2025.1511942 | Imane Salmam | https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2025.1511942/full | Long COVID individuals, on average 329 days post-infection, experience enduring physical and health-related challenges, with significant implications for their overall well-being. LCG (Long COVID group) showed significantly higher pain, comorbidities, and fatigue, along with lower HRQoL (health-related quality of life) and sleep quality compared to the other groups. | |||||||||||||||||||||
744 | Post COVID-19 infection and quality of life of healthcare workers at Sahloul University Hospital of Sousse in Tunisia | 2025-01-29 | https://doi.org/10.1007/s11136-024-03878-8 | Amene Fki | https://link.springer.com/article/10.1007/s11136-024-03878-8#citeas | HCWs experienced a significant deterioration in HRQoL after COVID-19 with a high incidence of post-COVID-19 syndrome. Post covid-19 syndrome was reported in 65% of cases. A low overall quality of life (QoL) score was reported in 28.6% of cases. Low physical and mental composite scores were reported in 34.3% and 29.4% of cases respectively. | |||||||||||||||||||||
745 | Ovarian function after COVID-19: long-term effects and vaccine safety in ART patients | 2025-01-30 | https://doi.org/10.1007/s10815-025-03403-x | Yamila Herrero | https://link.springer.com/article/10.1007/s10815-025-03403-x | Findings revealed a reduction in the number of retrieved and mature oocytes in patients over 36 years in the post-COVID-19 group. Lower IL-1β levels were found in follicular fluid (FF) of post-COVID-19 patients, while VEGF levels were reestablished between 9 and 18 months post-infection. | |||||||||||||||||||||
746 | The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study | 2025-01-30 | https://doi.org/10.1186/s12879-025-10526-0 | Federico Banchelli | Long-term effects of COVID-19 include an increase in the healthcare burden especially in the first months after the acute infection. The pooled outputs showed an increase in rates of outpatient visits and diagnostics starting from month 2 after SARS-CoV-2 infection (IRR = 1.68, 95% CI = 1.56–1.81) with a peak at month 4 (IRR = 2.05, 95% CI = 1.95–2.15); the increase continued with reduced intensity up to month 15. | ||||||||||||||||||||||
747 | Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19 | 2025-01-31 | https://doi.org/10.1007/s11033-025-10289-6 | Esra Yilmaz | https://link.springer.com/article/10.1007/s11033-025-10289-6 | We conclude that SARS-CoV-2 infection triggers fibrosis by increasing MAP2K4 regulation. | |||||||||||||||||||||
748 | Posttraumatic stress and growth in pulmonary patients recovered from COVID-19 | 2025-01-31 | https://doi.org/10.1038/s41598-025-88405-6 | Joanna Milanowska | https://www.nature.com/articles/s41598-025-88405-6 | Results revealed that 40.32% of participants exhibited PTSD symptoms. Key predictors of PTSD severity included cognitive symptoms and post-COVID self-rated health, with cognitive symptoms positively associated and self-rated health negatively associated with PTSD severity. The high prevalence of PTSD symptoms observed underscores the urgent need for integrated care addressing both psychological and physical health issues. | |||||||||||||||||||||
749 | Impact of Covid-19 infection on thyroid functions | 2025-01-31 | https://doi.org/10.1186/s43168-025-00366-6 | Hanaa S. Hamed | https://link.springer.com/article/10.1186/s43168-025-00366-6 | Upon admission, thyroid function tests (TFTs) were normal in 14.9% of patients. Two years after discharge, only 43.4% had normal TFTs, while 10.1% were being treated for hypothyroidism and 46.5% for hyperthyroidism. Our findings suggest that thyroid disorder, particularly hyperthyroidism or subclinical hyperthyroidism, hypothyroidism or subclinical hypothyroidism may be a common sequela in patients recovering from COVID-19, especially those with more severe illness. | |||||||||||||||||||||
750 | Incidence, pathophysiology, risk factors, histopathology, and outcomes of COVID-19-induced acute kidney injury: a narrative review | 2025-01-31 | https://doi.org/10.1016/j.micpath.2025.107360 | Abdelhamid Hachimi | AKI among COVID-19 patients is a frequent condition, associated with poor outcomes, and high mortality rates, especially in those with severe AKI. The pooled incidence of AKI among COVID-19 was 19.45% and a mortality rate of 54.24%. The mortality rate ranged from one third to approximately three quarters of AKI in COVID-19 patients. | ||||||||||||||||||||||
751 | Differential Fatigue Profile in Patients with Post-COVID Condition, Fibromyalgia, and Multiple Sclerosis | 2025-02-02 | https://doi.org/10.3390/jcm14030952 | PMC11818582 | Silvia Oliver-Mas | https://pmc.ncbi.nlm.nih.gov/articles/PMC11818582/ | Fatigue intensity was significantly higher in PCC and fibromyalgia compared to MS. Delayed fatigue and reduced benefits from rest were more pronounced in both PCC and fibromyalgia. | ||||||||||||||||||||
752 | Postacute COVID-19 fatigue, dyspnea and reduced activity in children and adolescents | 2025-02-03 | https://doi.org/10.1038/s41390-025-03897-2 | Chia-Wei Lin | https://www.nature.com/articles/s41390-025-03897-2 | Children and adolescents with postacute COVID-19 syndrome, particularly older individuals, experience greater fatigue and reduced physical activity than controls. Children with postacute COVID-19 syndrome reported significantly greater fatigue, increased dyspnea than controls. They also had a higher prevalence of mixed (8.1% vs. 1.7%, p = 0.029) and restrictive lung disease (29.7% vs. 10.8%, p = 0.001). | |||||||||||||||||||||
753 | Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 | 2025-02-03 | https://doi.org/10.1038/s43856-025-00745-6 | Lesly Ibargüen-González | https://www.nature.com/articles/s43856-025-00745-6 | Our data indicate the human pancreas as a SARS-CoV-2 target with plausible signs of injury and demonstrate that the host factor PLAC8 is required for SARS-CoV-2 pancreatic infection. We report a 3- to 4-fold increase between critical vs severe subgroups in the proportion of patients with elevated plasmatic pancreatic lipase and amylase, respectively. The increased values are associated with histopathological changes and indicate the presence of an injury of the pancreas in COVID-19 patients | |||||||||||||||||||||
754 | Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review | 2025-02-03 | https://doi.org/10.3389/fendo.2024.1477389 | Anisha Panesar | https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1477389/full | Following SARS-CoV-2 infection, SAT (subacute thyroiditis), NTIS (nonthyroidal illness syndrome), and new-onset autoimmune thyroid disorders are the most common thyroid abnormalities. | |||||||||||||||||||||
755 | Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID | 2025-02-04 | https://doi.org/10.1186/s12916-025-03881-x | Andrea Polli | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-03881-x | We confirm previous research showing that about a third of patients with COVID-19 reported persistent symptoms at 4 to 24 months after infection. Over 35% of patients infected with SARS-CoV-2 reported at least 2 persistent symptoms between 4 and 24 months after infection. | |||||||||||||||||||||
756 | Post-COVID-19 pulmonary fibrosis: Mechanisms, biomarkers, and therapeutic perspectives | 2025-02-04 | https://doi.org/10.1002/ctd2.70034 | Urvinder Kaur Sardarni | https://onlinelibrary.wiley.com/doi/10.1002/ctd2.70034 | PF (pulmonary fibrosis) as a complication of COVID-19 presents a significant clinical challenge with considerable implications for long-term patient outcomes. Current evidence highlights the multifactorial pathogenesis of post-COVID-19 PF, involving oxidative stress, EMT, dysregulated immune responses, and molecular pathways. | |||||||||||||||||||||
757 | An updated review of pulmonary radiological features of acute and chronic pulmonary COVID-19 | 2025-02-05 | https://doi.org/10.1097/mcp.0000000000001152 | Tcheroyan, Raya | https://journals.lww.com/co-pulmonarymedicine/abstract/9900/an_updated_review_of_pulmonary_radiological.222.aspx | The most common chronic imaging finding is ground-glass opacities, which commonly resolves, as well as subpleural bands and reticulation. Pulmonary fibrosis is an overall rare complication of COVID-19, with characteristic features, including architectural distortion, and traction bronchiectasis. | |||||||||||||||||||||
758 | Long-COVID incidence proportion in adults and children between 2020 and 2024 | 2025-02-05 | https://doi.org/10.1093/cid/ciaf046 | Hannah Mandel | https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf046/8002322?login=false | Overall, 4% of children and 10-26% of adults developed long-COVID, depending on computable phenotype used. Multiple studies have found long-COVID symptoms to be less common after Omicron-era infections. Our results suggest otherwise; consistent with other literature, incident longCOVID has not diminished. | |||||||||||||||||||||
759 | Outcomes of COVID-19 in the Omicron-predominant wave: large-scale real-world data analysis with a comparison to influenza | 2025-02-05 | https://doi.org/10.1186/s41479-025-00158-y | Koichi Miyashita | https://link.springer.com/article/10.1186/s41479-025-00158-y | In the Omicron-predominant wave, the mortality rate of COVID-19 decreased, but the number of patients increased, leading to a substantial increase in the number of deaths, especially among the elderly. The mortality rate of COVID-19 was higher than that of influenza in the elderly but not in the young. | |||||||||||||||||||||
760 | Post-Viral Frailty in Long COVID: A Distinct Phenotype within Veterans | 2025-02-05 | https://doi.org/10.1101/2025.02.04.25321653 | Jerry Bradley, | https://www.medrxiv.org/content/10.1101/2025.02.04.25321653v1 | Patients from the Long COVID clinic were significantly younger than those from the frailty clinic (60±12.6 vs.. 79.8±5.8, p<0.01). Patients with frailty in the Long COVID group experienced exhaustion and low activity at a higher rate than those in the Geriatric frailty clinic. | |||||||||||||||||||||
761 | Prevalence and Impact of Post-Exertional Malaise on Recovery in Adults with Post COVID-19 Condition. A Systematic Review with Meta-Analysis | 2025-02-05 | https://doi.org/10.1016/j.apmr.2025.01.471 | Dimitra V Pouliopoulou | https://www.archives-pmr.org/article/S0003-9993(25)00501-5/fulltext | Our research confirms that there is a large burden of PEM (Post-Exertional Malaise) in adults living with PCC. The prevalence of PEM in community-dwelling adults living with PCC was 36% (95% CI: 0.19 to 0.57; 2,263 participants). | |||||||||||||||||||||
762 | Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients with coronavirus disease-19 | 2025-02-06 | https://doi.org/10.1186/s40560-025-00777-z | Junji Hatakeyama | https://link.springer.com/article/10.1186/s40560-025-00777-z | Among 334 patients (who survived COVID-19 requiring mechanical ventilation), PICS (Post-intensive care syndrome) prevalence rates in the four completed questionnaires were 72.1, 78.5, 77.6, and 82.0% (every six months over a two-year period.), with cognitive impairment being the most common and lower QOL being noted when multiple impairments coexisted. Cognitive function and mental health revealed considerable variability, with many patients showing fluctuating ratings in the later surveys. | |||||||||||||||||||||
763 | Severity Matters: How COVID-19 Severity Impacts Long-Term Effects on Symptoms, Physical Activity and Functionality—An Observational Study | 2025-02-06 | https://doi.org/10.3390/healthcare13030333 | PMC11817242 | Laura Pérez-Gisbert | https://pmc.ncbi.nlm.nih.gov/articles/PMC11817242/ | Patients with more severe COVID-19 also experience greater frailty, dysphagia, fatigue, dyspnoea, and pain. Additionally, those with severe cases have poorer overall health, reduced physical activity, and diminished functionality. | ||||||||||||||||||||
764 | Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review | 2025-02-07 | https://doi.org/10.3390/biomedicines13020407 | Charalampos Voros | https://www.mdpi.com/2227-9059/13/2/407 | SARS-CoV-2 infection impairs ovarian function by causing oxidative stress, inflammation, and hormonal disruption, thereby increasing the incidence of POI (Premature ovarian insufficiency). Although many effects appear to be temporary, the possibility of long-term reproductive repercussions cannot be dismissed. | |||||||||||||||||||||
765 | Profiling the persistent and episodic nature of long COVID symptoms and the impact on quality of life and functional status: a cohort observation study | 2025-02-07 | DOI: 10.7189/jogh.15.04006 | Rebecca Owen | The data demonstrates little or no improvement over 16 weeks, while the frequency of contact throughout the study demonstrates the episodic and relapsing nature of long COVID. It is evident from the data across the patient profiles that performance in all areas of the study was well below expected clinically relevant ranges when compared to existing clinical and normative data sets. The burden of symptoms for patients demonstrates little to no progress towards pre-COVID-19 levels. | ||||||||||||||||||||||
766 | Pediatric Gastrointestinal Tract Outcomes During the Postacute Phase of COVID-19 | 2025-02-07 | doi:10.1001/jamanetworkopen.2024.58366 | Dazheng Zhang | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2830031 | Documented SARS-CoV-2 infection was associated with GI tract symptoms and diseases during the postacute phase. Children and adolescents with documented SARS-CoV-2 infection faced a 25% higher risk of newly diagnosed GI tract symptoms and disorders during the postacute phase compared with those without documented SARS-CoV-2 infection (incidence, 8.64% vs 6.85%). | |||||||||||||||||||||
767 | Increased Risk of Hospitalization for Various Disorders After COVID-19 Infection: A Cohort Study of the UK Biobank Spanning over a hundred Disease Categories | 2025-02-07 | https://doi.org/10.1016/j.jmii.2025.02.001 | Yong XIANG | https://www.sciencedirect.com/science/article/pii/S1684118225000349 | This study revealed increased risk of hospitalization from a wide variety of pulmonary and extra-pulmonary diseases after COVID-19, especially for severe infections. Compared to individuals with no known COVID-19 history, those with severe COVID-19(hospitalized) exhibited increased hazards of hospitalization due to multiple disorders(median follow-up=261 days), including disorders of respiratory, cardiovascular, neurological, gastrointestinal, genitourinary, musculoskeletal systems, as well as injuries, infections and non-specific symptoms. Mild COVID-19 cases were associated with a significantly increased risk of hospitalization due to aspiration pneumonitis at 3-6 months and after 6 months. | |||||||||||||||||||||
768 | Examining recovery trajectories of physical function, activity performance, cognitive and psychological functions, and health related quality of life in COVID-19 patients treated in ICU: a Swedish prospective cohort study | 2025-02-08 | https://doi.org/10.1080/09638288.2025.2460722 | Susanne Palmcrantz | https://www.tandfonline.com/doi/full/10.1080/09638288.2025.2460722#abstract | Despite improvements in functioning and health in this group of predominantly younger age recovery did not reach population norms. These results highlight persistent impairments and activity limitations that may necessitate long-term healthcare interventions. Persisting impairments after ICU-treated COVID-19 occurred in multiple areas including pain, endurance, dyspnea, mental and physical fatigue. | |||||||||||||||||||||
769 | Post COVID-19 condition in hospitalized survivors after one year of infection during the Alpha- and Delta-variant dominant waves in Japan: COVID-19 Recovery Study II | 2025-02-08 | https://doi.org/10.2188/jea.je20240179 | Yoko Muto | https://pubmed.ncbi.nlm.nih.gov/39924249/ | Of the respondents, 45.4% had at least one PCC symptom one year after infection. The common symptoms included dyspnea (20.7%), fatigue/malaise (17.6%), muscle weakness (15.4%), decrease in concentration (13.4%), and sleep disorder (13.3%), followed by brain fog (8.4%). Among patients with PCC, 14.0% had anxiety (HADS-Anxiety ≥11), and 18.6% had depression (HADS-Depression ≥11), with four times higher proportions than those without PCC | |||||||||||||||||||||
770 | Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients | 2025-02-10 | https://doi.org/10.1136/bmjresp-2023-001985 | PMC11815400 | Robert Sykes | https://pmc.ncbi.nlm.nih.gov/articles/PMC11815400/ | Persistent radiological abnormalities post-COVID-19 were common at 28–60 days postdischarge from hospital, although most improved. Patients with persisting radiological abnormalities 28–60 days postdischarge are at risk of persisting health impairment in the longer term and represent a population for targeted intervention. 88 (56%) patients of the COVID-19 cohort had persisting radiological abnormalities at 28–60 days postdischarge. This included ground-glass opacification (45%), reticulation/architectural distortion (30%) or mixed pattern (19%). | ||||||||||||||||||||
771 | Effect of SARS-CoV-2 infection on sperm telomere length | 2025-02-11 | https://doi.org/10.1007/s10815-025-03408-6 | Murilo Racy Soares | https://link.springer.com/article/10.1007/s10815-025-03408-6 | This study revealed that SARS-CoV-2 infection reduced sperm telomere length without alterations in semen parameters or hormonal levels. These results provide further evidence that SARS-CoV-2 infection can induce genomic alterations in human sperm. Sperm telomere length was significantly diminished in the COVID-19 positive group with a mean difference of 0.635 compared to the negative group (p = 0.041). | |||||||||||||||||||||
772 | Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence | 2025-02-11 | https://doi.org/10.1007/s40618-025-02544-1 | Luigi di Filippo | https://link.springer.com/article/10.1007/s40618-025-02544-1 | We observed that prevalent VFs detected at hospital admission were distinctive clinical features of patients presenting with Long COVID 6-months after discharge, independently from acute disease severity and other confounding factors. Those presenting VFs (vertebral fractures) were characterized by a significant higher prevalence of Long COVID (28.6% vs. 9.5%, p = 0.04) | |||||||||||||||||||||
773 | Investigation of renal function in patients with long COVID in the Amazon region: a cross-sectional study | 2025-02-11 | https://doi.org/10.1186/s12879-024-10355-7 | Gabriela Maria Coimbra Coelho de Assis | https://link.springer.com/article/10.1186/s12879-024-10355-7 | A decline in renal function was common in patients with Long COVID in this study, and older age and glycaemic alterations were relevant to this condition. Patients over 60 years (29.6%) and those who developed glycaemic alterations (41.8%) exhibited a higher prevalence of renal outcomes in long COVID. | |||||||||||||||||||||
774 | Focusing on post-COVID syndrome fatigue | 2025-02-11 | https://doi.org/10.1016/j.nrleng.2025.02.002 | M Gómez-Eguílaz | https://pubmed.ncbi.nlm.nih.gov/39947285/ | At 6 months, physical fatigue improves, but psychological fatigue does not. Significant differences were found in sleepiness, cognitive deterioration, anxiety and quality of life. Significant alterations are evident of TNF-α values, but not in the rest of the cytokines. | |||||||||||||||||||||
775 | Cluster analysis of post-COVID-19 physical and mental health outcomes 3–6 months after SARS-CoV-2 infection: results of the French Prospective ALCOVID Cohort Study | 2025-02-11 | https://doi.org/10.1136/bmjopen-2024-089136 | PMC11815462 | Thomas Escoda | https://pmc.ncbi.nlm.nih.gov/articles/PMC11815462/ | A significant proportion of COVID-19 outpatients or inpatients reported a large number of symptoms 3–6 months post COVID-19 infection, with a predominance of fatigue, mood disorders, PTSD, neurocognitive disorders and respiratory symptoms. A total of 210 patients agreed to participate, of which 157 (75%) reported at least one symptom at the 3–6 months visit; mostly asthenia, dyspnoea, psychiatric disorders such as anxiety, depression, post-traumatic stress disorder and cognitive disorders. | ||||||||||||||||||||
776 | Healthcare Resource Utilization (HCRU) and Direct Medical Costs Associated with Long COVID or Post-COVID-19 Conditions: Findings from a Literature Review | 2025-02-12 | https://doi.org/10.3390/jmahp13010007 | Elżbieta Łukomska | https://www.mdpi.com/2001-6689/13/1/7 | Individuals with LC had significantly elevated HCRU (healthcare resource use) and healthcare costs vs. controls without a COVID-19 diagnosis over ≥15 months, with a 7.6–13.1% increase in total healthcare costs per person per month as assessed by difference-in-difference analysis. Among studies that did not specifically refer to LC, having a COVID-19 diagnosis was associated with a significant 4–10% increase in long-term total HCRU over 6–8 months and a 1.3- to 2.9-fold relative increase in total healthcare costs over 6 months. | |||||||||||||||||||||
777 | Association between Mexican vaccination schemes and the duration of long COVID syndrome symptoms | 2025-02-12 | https://doi.org/10.1038/s41598-024-59954-z | PMC11821848 | Juan Francisco Rodriguez-Torres | https://pmc.ncbi.nlm.nih.gov/articles/PMC11821848/ | In this cross-sectional observational study, a prevalence of 20.9% of Long COVID was observed, with 64 patients (7.9%) experiencing symptoms associated with Long COVID lasting over a year. We monitored our patients for a median of 488.5 days and noted that 7.9% of our population continued to experience one or more Long COVID syndrome-associated symptoms for over a year, with fatigue, tiredness, hair loss, cough, and insomnia being the most common. | ||||||||||||||||||||
778 | Genotoxic risks in patients with COVID-19 | 2025-02-13 | https://doi.org/10.1016/j.meegid.2025.105728 | Nurşen Başaran | https://www.sciencedirect.com/science/article/pii/S1567134825000176 | Some SARS-CoV-2 proteins directly induce DNA damage. Indirect action via triggering oxidative stress or inhibition of DNA repair pathways also occurs, further weakening the resistance to infection and forming a vicious circle. The level of DNA damage correlates with the severity of the disease and influences sequelae during the post-COVID-19 period. | |||||||||||||||||||||
779 | Differences in Long COVID severity by duration of illness, symptom evolution, and vaccination: a longitudinal cohort study from the INSPIRE group | 2025-02-14 | https://doi.org/10.1016/j.lana.2025.101026 | Michael Gottlieb | https://www.sciencedirect.com/science/article/pii/S2667193X25000365 | Among participants followed up to 3 years after initial infection, those with current Long COVID had worse physical and mental health outcomes. The majority of those with Long COVID did not resolve, with less than 2% having resolved Long COVID. The resolved Long COVID cohort had moderately worse physical and mental health compared with those never-having-Long COVID. | |||||||||||||||||||||
780 | Impact of long COVID on self-reported disease activity, disability, and quality of life in individuals with inflammatory arthritis | 2025-02-17 | https://doi.org/10.1016/j.semarthrit.2025.152657 | Zachary S. Wallace | https://www.sciencedirect.com/science/article/abs/pii/S0049017225000289 | The most common long COVID symptoms were fatigue (37.3 %), altered smell/taste (27.1 % and 25.4 %), difficulty breathing (20.3 %), and headache (15.3 %). Those with vs. without long COVID had worse mHAQ (modified health assessment questionnaire), RAPID-3 (Routine Assessment of Patient Index Data 3), and physical and mental health (). Fatigue and pain were worse in those with vs. without long COVID (p < 0.05 for comparisons). Similar trends were observed in those with long COVID vs. those without prior COVID-19. | |||||||||||||||||||||
781 | Pulmonary function and comparative SARS-CoV-2 RBD-specific IgG antibody response among the COVID-19 recovered group | 2025-02-18 | https://doi.org/10.1101/2025.02.17.25321314 | Abu Bakar Siddik | https://www.medrxiv.org/content/10.1101/2025.02.17.25321314v1 | Pulmonary functional abnormalities were prevalent in the recovered group who previously exhibited different symptoms (53% mild, 66% moderate, and 50% severe) compared to the control group (23%). | |||||||||||||||||||||
782 | Alterations in Gut Microbiome Composition and Increased Inflammatory Markers in Post-COVID-19 Individuals | 2025-02-18 | https://doi.org/10.1007/s12035-025-04769-w | Tatiana Barichello | https://link.springer.com/article/10.1007/s12035-025-04769-w | Post-COVID-19 individuals exhibited a decreased abundance of phylum, class, and order of Verrucomicrobia, family, and genus of Akkermansia, a short-chain fatty acid producer and microbial group significantly associated with intestinal barrier homeostasis and the amelioration of metabolic diseases. In post-COVID-19 individuals, there were elevated IL-17 and MPIF-1 levels, compared to non-COVID-19 individuals. Additionally, there were notable alterations in gut microbiome composition, as evidenced by changes in β-diversity and a decrease of Verrucomicrobia, family, and Akkermansia genus abundance. | |||||||||||||||||||||
783 | Demographic, epidemiological and clinical profile of patients with post-COVID syndrome followed at a teaching hospital in Brazil | 2025-02-19 | https://doi.org/10.1016/j.bjid.2025.104509 | João Paulo Borges de Melo | https://www.sciencedirect.com/science/article/pii/S1413867025000121 | Most cases of PCS occurred in individuals with the mild form of COVID-19. The predominant symptoms were chronic fatigue in 59 (68.6 %) cases, brain fog in 68 (73.4 %), myalgias and arthralgias in 44 (47.8 %), cramps and paresthesia's in 40 (46.5 %). The persistence of symptoms was greater in those cases who presented severe forms of COVID-19. Most patients experienced gradual and progressive improvement over the months. | |||||||||||||||||||||
784 | Oral Cavity Serves as Long-Term COVID-19 Reservoir with Increased Periodontal and Viral Disease Risk | 2025-02-19 | https://doi.org/10.1101/2025.02.17.638734 | Joel Schwartz | https://www.biorxiv.org/content/10.1101/2025.02.17.638734v1 | The oral cavity serves as a long-term viral reservoir, and periodontal inflammation with increased oral viral presence in COVID-positive patients may increase susceptibility to oral and non-oral viral diseases and identify risk for long COVID. Notably, 3-6 months post-infection, while SARS-CoV-2 Spike (S) transcript was rarely detected in saliva (~6%), its protein was commonly detected (~70%) in the COVID-19 positive subjects indicating incomplete viral clearance.Our results identified racial disparity indicating oral associated post-acute sequelae (PASC) primarily manifested as periodontal (gum) disease (COVID-19 positive: ~73% vs COVID-19 negative: ~33%) and correlated with higher rates of dry mouth (57.5%), taste disturbance (47%), and smell loss (20%). | |||||||||||||||||||||
785 | The Effects of COVID-19 on Tinnitus Severity and Quality of Life in Individuals With Subjective Tinnitus | 2025-02-19 | https://doi.org/10.1002/brb3.70317 | Zehra Aydogan | https://onlinelibrary.wiley.com/doi/10.1002/brb3.70317 | Although negative effects of the pandemic were observed in individuals with tinnitus who were not infected with COVID-19, both the quality of life and tinnitus severity of individuals with tinnitus who were infected with COVID-19 worsened. There was a significant increase in tinnitus severity after COVID-19 infection in Group 2 (p < 0.05). Moreover, it was found that the VAS (loudness and annoyance), THI (functional, emotional, catastrophic, and total score), and SF-36 (physical function, physical role, pain, general health, vitality, emotional role, and social function) values worsened significantly compared to before COVID-19 infection (p < 0.05). | |||||||||||||||||||||
786 | Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients | 2025-02-21 | https://doi.org/10.1038/s41598-025-88904-6 | Hideaki Kato | https://www.nature.com/articles/s41598-025-88904-6 | The present study showed that 19% of the male patients admitted by COVID-19 developed erectile dysfunction one and two year after COVID-19 in the Japanese cohort. | |||||||||||||||||||||
787 | Long COVID has variable incidence and clinical presentations: our 6-country collaborative study | 2025-02-21 | https://doi.org/10.1007/s10787-025-01640-1 | Sandor Szabo | https://link.springer.com/article/10.1007/s10787-025-01640-1 | We found that the incidence of Long COVID varied from 46 (Mexico) to 17% (Ukraine), the average being 25%. In a summary evaluation of all 6 countries, we characterized as “general” the most frequent presenting signs and symptoms: fatigue (47%), hair loss (39.2%), and myalgia (35%), but no two countries demonstrated the same top 3 clinical signs/symptoms. | |||||||||||||||||||||
788 | Three-Year Follow-Up of COVID-19 Cases in District of Constance, Germany. A Prospective, Controlled Cohort Study (FSC19-KN) | 2025-02-21 | https://doi.org/10.3390/jcm14051439 | Ann-Kathrin Kohler | https://www.mdpi.com/2077-0383/14/5/1439 | Hospitalization rate did not differ significantly between the two groups of initially infected and non-infected subjects (cumulative events, verum group 57 to control group 45, OR 1.24, CI 0.83; 1.85, p = 0.30). However, the health-related quality of life, measured by SF-36 sub scores of the SARS-CoV-2-positive subjects, achieved significantly lower results | |||||||||||||||||||||
789 | Long-term clinical outcome and exercise capacity in SARS-CoV-2-positive elite athletes | 2025-02-21 | https://doi.org/10.1007/s12662-025-01024-1 | Katharina Diebold | https://link.springer.com/article/10.1007/s12662-025-01024-1 | 37% experienced symptoms lasting > 4 weeks. Over 50% of athletes paused their training for 4–8 weeks. At t1, 40% still experienced reduced perceived performance capacity (PPC) compared to their pre-COVID-19 level, while 64% reported ongoing limitations in sports participation, with mental and physical fatigue as the most prominent limiting factor, followed by shortness of breath and joint and muscle pain. | |||||||||||||||||||||
790 | Presence and Evolution of Radiological Changes at 6 and 12 Months After COVID-19 Pneumonia and Their Risk Factors | 2025-02-22 | https://doi.org/10.3390/medicina61030382 | Celia Roig-Martí | https://www.mdpi.com/1648-9144/61/3/382 | Our results suggest that long-term radiological abnormalities after COVID-19 pneumonia were common even one year after COVID-19 pneumonia. Parenchymal patterns seem to be more frequent than reticular and fibrotic patterns, and the fibrotic pattern was the only one that worsened significantly over time. This was evidenced by a significant increase in the number of lung segments with bronchiectasis at 12 months. | |||||||||||||||||||||
791 | Identification of post-COVID condition in a large population: a machine learning approach | 2025-02-22 | https://doi.org/10.1007/s44203-025-00007-w | Tkt Lo | https://link.springer.com/article/10.1007/s44203-025-00007-w | Applying the model to a population-based sample of 3.3 million identified 309,390 persons living with PCC, or a period prevalence estimate of 9.3%. Considering the underdetection of SARS-CoV-2 infections and undercoding of long-COVID in health data in many jurisdictions, the demonstrated approach would provide a practical alternative to identify persons living with PCC. | |||||||||||||||||||||
792 | Age- and disease severity-associated changes in the nasopharyngeal microbiota of COVID-19 patients | 2025-02-22 | https://doi.org/10.1016/j.isci.2025.112091 | Fernando Pérez-Sanz | https://www.sciencedirect.com/science/article/pii/S2589004225003517 | This revealed that bacterial alpha diversity decreases progressively throughout life but only in severely ill COVID-19 patients, in whose nasopharynx, moreover, several opportunistic pathogen bacterial genera are overrepresented. | |||||||||||||||||||||
793 | Phase-resolved Functional Lung MRI Reveals Distinct Lung Perfusion Phenotype in Children and Adolescents with Post–COVID-19 Condition | 2025-02-25 | https://doi.org/10.1148/radiol.241596 | Gesa H. Pöhler | https://pubs.rsna.org/doi/10.1148/radiol.241596 | Free-breathing phase-resolved functional lung MRI–derived parameters helped identify a distinct phenotype of lung perfusion in children and adolescents with PCC and were correlated with heart rate and chronic fatigue severity. Participants with PCC had lower regional ventilation and quantified perfusion. Participants with PCC and cardiopulmonary symptoms had lower FVL-CMs (flow-volume loop correlation metric) and higher ventilation defect and perfusion defect percentage compared with matched control participants. In participants with PCC, greater lung perfusion correlated with increased chronic fatigue severity and higher ventilation-perfusion mismatch correlated with increased heart rate. | |||||||||||||||||||||
794 | Assessing the effects of long-COVID on mental health in the United States: a population based study | 2025-02-24 | https://doi.org/10.1007/s44192-025-00142-4 | Anusua Datta | https://link.springer.com/article/10.1007/s44192-025-00142-4 | Approximately 51.8% of those surveyed tested positive for COVID-19 and of these 27.3% reported suffering from long-COVID. Individuals with long-COVID were twice as likely to experience anxiety and depression relative to those with mild/asymptomatic COVID-19. Our analysis at the sub-group level revealed that younger adults and females were disproportionately affected, reporting higher rates of anxiety and depression in both the COVID-19 and long-COVID groups. | |||||||||||||||||||||
795 | Health-Related Quality of Life One Year After Intensive Care Unit Admission for COVID-19: A Retrospective, Cross-Sectional, Longitudinal Observational Study | 2025-02-24 | https://doi.org/10.1002/hsr2.70507 | Carina M. Samuelsson | https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70507 | Impaired HRQoL is common 1 year after COVID-19 following ICU care. In this follow up, more than two-thirds reported problems related to pain/discomfort and half reported problems related to anxiety/depression. | |||||||||||||||||||||
796 | Anxiety and Depression Among Astana Reinfected Patients at 1-, 3-, and 6-Month Follow-Up in the Post-COVID Center | 2025-02-24 | https://doi.org/10.1155/carj/5596465 | Makhabbat Bekbossynova | https://onlinelibrary.wiley.com/doi/10.1155/carj/5596465 | Self-reported fatigue during the acute phase was prevalent among 79% of participants, which increased to 91% at 1 month, decreased to 64% at 3 months, and further decreased to 56% at 6 months. Anxiety and depression symptoms persisted in 17% and 21% of patients, respectively, up to the 6-month mark; even though during the acute phase, these figures were 15% and 13%. | |||||||||||||||||||||
797 | Post-COVID-19 condition in prospective inpatient and outpatient cohorts | 2025-02-26 | https://doi.org/10.1038/s41598-025-90819-1 | Antti Hurme | https://www.nature.com/articles/s41598-025-90819-1 | our study showed that a severe COVID-19 predisposes to persistent symptoms after infection. Still, similar symptoms were also found with lower frequency among outpatients who suffered from a mild to moderate form of COVID-19. The prevalence of PCC, as assessed by four medical specialists, decreased from 51% at three months to 18% at 24 months. | |||||||||||||||||||||
798 | Factors associated with reduction in quality of life after SARS-CoV-2 infection | 2025-02-26 | https://doi.org/10.1038/s41598-025-91388-z | Christian Neumann | https://www.nature.com/articles/s41598-025-91388-z | A statistically significant improvement in HrQoL was observed during the observation period. At baseline, 39% of the variance in HrQoL was explained by fatigue, muscle pain, number of remaining symptoms (RS), perceived stress, and age. At follow-up, fatigue, RS, perceived stress, muscle and joint pain, and age explained 54% of the variance in HrQoL. | |||||||||||||||||||||
799 | Ongoing Symptoms After Acute SARS-CoV-2 or Influenza Infection in a Case-Ascertained Household Transmission Study: 7 US Sites, 2021–2023 | 2025-02-26 | https://doi.org/10.1093/cid/ciaf026 | Ayla Bullock | https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaf026/8040968 | These results suggest that SCV2 households have a significantly higher prevalence of ongoing symptoms compared with influenza households (OR: 1.78; 95% CI: 1.28–2.47). Among study participants with a documented infection, SCV2-positive participants had nearly twice the odds of ongoing symptoms as influenza-positive participants (OR: 1.92; 95% CI: 1.27–2.97). | |||||||||||||||||||||
800 | Long-term health outcomes following hospitalisation for COVID-19: a 30- month cohort analysis | 2025-02-27 | https://doi.org/10.1080/23744235.2025.2452862 | Sarah Tubiana | https://www.tandfonline.com/doi/full/10.1080/23744235.2025.2452862#abstract | COVID-19 hospitalised subjects were at increased risk of death or hospitalisation for various organ disorders up to 30 months after discharge, reflecting the multi-organ consequences of the disease. COVID-19 subjects were more likely to be hospitalised for cardiovascular (IRR 1.22 [1.15; 1.29]), psychiatric (IRR 1.41 [1.29; 1.53]), neurological (IRR 1.50 [1.41; 1.61]), and respiratory events (IRR 1.99 [1.87; 2.12]). The excess risk strongly decreased after the first 6 months for all outcomes but remained significantly increased up to 30-month for neurological, respiratory disorders, chronic renal failure and diabetes. |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 108 | |||||||||||||||||||||||||
3 | Placental Tissue Destruction and Insufficiency From COVID-19 Causes Stillbirth and Neonatal Death From Hypoxic-Ischemic Injury: A Study of 68 Cases With SARS-CoV-2 Placentitis From 12 Countries | 2022-02-10 | https://doi.org/10.5858/arpa.2022-0029-SA | David A. Schwartz | https://meridian.allenpress.com/aplm/article/146/6/660/477699/Placental-Tissue-Destruction-and-Insufficiency | We found that SARS-CoV-2 placentitis can cause extensive placental damage as a result of destructive lesions, and that the damage can be further exacerbated by additional pathology abnormalities. The fetal hypoxia that ensues can lead to a hypoxic-ischemic fetal demise or neonatal death. It is very fortunate that this sequence of events develops in only a small percentage of pregnant women having COVID-19. | |||||||||||||||||||||
4 | COVID-19 in pregnancy: implications for fetal brain development | 2022-02-13 | https://doi.org/10.1016/j.molmed.2022.02.004 | Lydia L. Shook | https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(22)00045-4 | The data presented here demonstrate the potential for maternal SARS-CoV-2 infection to drive maternal, placental, and fetal immune activation, and thus the potential for adverse fetal neurodevelopmental programming. | |||||||||||||||||||||
5 | Placental vascular remodeling in pregnant women with COVID-19 | 2022-07-29 | https://doi.org/10.1371/journal.pone.0268591 | Sergiy G. Gychka | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268591 | The major finding of this study is that the placental arteries of women who gave birth to live full-term newborns, but contracted SARS-CoV-2 during pregnancy, exhibited severe vascular remodeling. Such changes in placental vessels occurred in all mothers who tested positive for COVID-19 as determined by RT-PCR tests, irrespective of the presence or absence of COVID-19-associated symptoms. | |||||||||||||||||||||
6 | SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy | 2022-08-19 | https://doi.org/10.1038/s41390-022-02266-7 | Jin, J.C. | https://www.nature.com/articles/s41390-022-02266-7#citeas | This cohort study investigated stool from 14 newborns born at 25–41 weeks admitted at delivery to our urban academic hospital whose mothers had COVID-19 during pregnancy. Eleven mothers had COVID-19 resolved more than 10 weeks before delivery. Despite negative SARS CoV-2 nasal PCRs from all newborns, viral RNAs and Spike protein were detected in the stool of 11 out of 14 newborns as early as the first day of life and increased over time in 6. | |||||||||||||||||||||
7 | Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cell in recovered COVID-19 pregnant women | 2022-08-19 | https://doi.org/10.1101/2022.08.18.504053 | Nor Haslinda Abd Aziz | https://www.biorxiv.org/content/10.1101/2022.08.18.504053v1 | Overall, our study highlights that SARS-CoV-2 infection deranged the adaptive immune response in pregnant women and could be implicated in pregnancy complications in ongoing pregnancies. | |||||||||||||||||||||
8 | Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis | 2022-08-24 | http://dx.doi.org/10.1136/bmjgh-2022-009495 | Emily R Smith | https://gh.bmj.com/content/bmjgh/8/1/e009495.full.pdf | Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (7.68x), admission to intensive care unit (3.81x), and being diagnosed with pneumonia (23.46x) and thromboembolic disease (5.50x). Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (1.86x) and be born preterm (1.71x), Infection was not linked to stillbirth. | |||||||||||||||||||||
9 | SARS-CoV-2 can infect human embryos | 2022-09-14 | https://doi.org/10.1038/s41598-022-18906-1 | Mauricio Montano | https://www.nature.com/articles/s41598-022-18906-1 | These findings confirm that human embryos at the blastocyst stage prior to implantation are susceptible to SARS-CoV-2 infection, which can impact their viability. | |||||||||||||||||||||
10 | Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection | 2023-01-16 | https://doi.org/10.1093/brain/awac372 | Marco Massimo | https://academic.oup.com/brain/article/146/3/1175/6985751?login=false | We report the presence of SARS-CoV-2 in first and second trimester foetal brain tissue in association with cortical haemorrhages. SARS-CoV-2 spike protein was sparsely detected within progenitors and neurons of the cortex itself, but was abundant in the choroid plexus of haemorrhagic samples. Cortical haemorrhages were linked to a reduction in blood vessel integrity and an increase in immune cell infiltration into the foetal brain. Our findings indicate that SARS-CoV-2 infection may affect the foetal brain during early gestation. | |||||||||||||||||||||
11 | Systematic review and synthesis of stillbirths and late miscarriages following SARS-CoV-2 infections | 2023-01-24 | https://doi.org/10.1016/j.ajog.2023.01.019 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9872559/ | Noemi Alcover | https://pubmed.ncbi.nlm.nih.gov/36706855/ | Fetal demise generally occurs a few days after the infection with histologic placental inflammatory lesions associated with transplacental SARS-CoV-2 transmission and eventually causing placental insufficiency. | ||||||||||||||||||||
12 | Developmental screening of full-term infants at 16 to 18 months of age after in-utero exposure to maternal SARS-CoV-2 infection | 2023-03-17 | https://doi.org/10.1038/s41372-023-01642-3 | Aashish V. Shah | https://www.nature.com/articles/s41372-023-01642-3 | We observed increased risk of neurodevelopmental delays during screening of infants born at full-term to mothers with SARS-CoV-2 at 16 to 18 months age. There were no differences in outcomes between infants born to asymptomatic and mildly symptomatic mothers. | |||||||||||||||||||||
13 | Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy | 2023-03-23 | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802745 | Andrea G. Edlow | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802745 | In adjusted regression models accounting for race, ethnicity, insurance status, hospital type (academic center vs community), maternal age, and preterm status, maternal SARS-CoV-2 positivity was associated with a statistically significant elevation in risk for neurodevelopmental diagnoses at 12 months among male offspring (adjusted OR, 1.94) but not female offspring (adjusted OR, 0.89). Similar effects were identified using matched analyses in lieu of regression. At 18 months, more modest effects were observed in male offspring (adjusted OR, 1.42). | |||||||||||||||||||||
14 | Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates | 2023-04-06 | https://doi.org/10.1542/peds.2022-058271 | Merline Benny, MD | https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2022-058271/191033/Maternal-SARS-CoV-2-Placental-Changes-and-Brain?autologincheck=redirected | We report 2 neonates born to SARS-CoV-2 positive mothers, who displayed early-onset (day 1) seizures, acquired microcephaly, and significant developmental delay over time. At birth, neither infant was SARS-CoV-2 positive (nasopharyngeal swab, reverse transcription polymerase chain reaction), but both had detectable SARS-CoV-2 antibodies and increased blood inflammatory markers. The constellation of clinical findings, placental pathology, and immunohistochemical changes strongly suggests that second-trimester maternal SARS-CoV-2 infection with placentitis triggered an inflammatory response and oxidative stress injury to the fetoplacental unit that affected the fetal brain. | |||||||||||||||||||||
15 | Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates | 2023-04-06 | https://doi.org/10.1542/peds.2022-058271 | Merline Benny | https://publications.aap.org/pediatrics/article/151/5/e2022058271/191033/Maternal-SARS-CoV-2-Placental-Changes-and-Brain?autologincheck=redirected | We report 2 neonates born to SARS-CoV-2 positive mothers, who displayed early-onset (day 1) seizures, acquired microcephaly, and significant developmental delay over time. At birth, neither infant was SARS-CoV-2 positive (nasopharyngeal swab, reverse transcription polymerase chain reaction), but both had detectable SARS-CoV-2 antibodies and increased blood inflammatory markers. In both infants, the neurologic findings at birth mimicked the presentation of hypoxic-ischemic encephalopathy of newborn and neurologic sequelae progressed well beyond the neonatal period. | |||||||||||||||||||||
16 | Severe Maternal Morbidity and Mortality of Pregnant Patients With COVID-19 Infection During the Early Pandemic Period in the US | 2023-04-07 | doi:10.1001/jamanetworkopen.2023.7149 | Koji Matsuo, MD, PhD | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803485 | This national-level analysis found substantial adverse maternal outcomes among pregnant patients with COVID-19 infection at delivery during the early pandemic in the US. Specifically, the odds of severe respiratory complications were increased among pregnant patients with COVID-19 infection at delivery. Greater than 10-fold increased maternal mortality risk associated with COVID-19 infection validates prior investigations with national-level data; moreover, increased failure-to-rescue risk following severe maternal morbidity among patients with COVID-19 adds important information. | |||||||||||||||||||||
17 | Fetal brain vulnerability to SARS-CoV-2 infection | 2023-08-01 | https://doi.org/10.1016/j.bbi.2023.06.015 | Courtney L. McMahon | https://www.sciencedirect.com/science/article/pii/S0889159123001599 | we found that viral transmission to the fetal tissues, including the brain, occurred at later developmental stages, and that infection primarily targeted male fetuses. Overall, these findings have concerning implications regarding neurodevelopment and pregnancy complications of the mother following prenatal COVID-19 exposure. | |||||||||||||||||||||
18 | Effect of COVID-19 vaccination and booster on maternal–fetal outcomes: a retrospective cohort study | 2023-08-01 | https://doi.org/10.1016%2FS2589-7500(23)00093-6 | PMC10473855 | Samantha N Piekos | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473855/ | Vaccinated pregnant people had lower rates of COVID-19 during pregnancy (4·0%) compared with unvaccinated matched people (5·3%; p<0·0001). COVID-19 rates were even lower in boosted people (3·2%) compared with vaccinated unboosted matched people (5·6%; p<0·0001). Vaccinated people were also less likely to have a preterm birth (7·9%; p<0·0001), stillbirth (0·3%; p<0·0002), or very low birthweight neonate (1·0%; p<0·0001) compared with unvaccinated matched people (preterm birth 9·4%; stillbirth 0·6%; very low birthweight 1·5%). | ||||||||||||||||||||
19 | Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study | 2023-10-24 | doi: 10.1136/bmjopen-2022-069194 | Viviana Fajardo Martinez | https://bmjopen.bmj.com/content/13/1/e069194 | Compared with prepandemic controls, infants exposed to antenatal COVID-19 more frequently had suboptimal neuromotor development. Sixteen infants (14%) had MOS-R scores <20 vs zero controls, p<0.001. At 6–8 months, 13 of 109 case infants (12%) failed to attain developmental milestones; all 115 control infants had normal development. | |||||||||||||||||||||
20 | Developmental impairment in children exposed during pregnancy to maternal SARS-COV2: A Brazilian cohort study | 2023-12-05 | https://doi.org/10.1016/j.ijid.2023.12.001 | Carolina A.D. Santos | https://www.ijidonline.com/article/S1201-9712(23)00802-0/fulltext | We followed 127 children for one year, 69 in the COVID-19-exposed Group (EG), and 68 in the control group (CG). 20.3% of EG children and 5.9% of the CG received a diagnosis of neurodevelopmental delay within 12 months of life. For the exposed group, the prevalence of neurodevelopment impairment using ASQ-3 was 35.7% at 4 months, 7% at 6 months, and 32.1% at 12 months. SARS-CoV-2 exposure was associated with neurodevelopmental impairment. | |||||||||||||||||||||
21 | Placental pathology in a large (Swedish) cohort of SARS-CoV-2 infected mothers | 2023-12-15 | https://doi.org/10.1016/j.placenta.2023.12.010 | Lisa Fredriksson | https://www.sciencedirect.com/science/article/pii/S0143400423006355 | The presence of SARS-CoV-2 placentitis does not seem to correlate with maternal factors or the severity of infection. It does correlate with development of placental dysfunction of acute/subacute onset and is often manifested as reduced fetal movements. | |||||||||||||||||||||
22 | Effects of novel coronavirus Omicron variant infection on pregnancy outcomes: a retrospective cohort study from Guangzhou | 2023-12-18 | https://doi.org/10.3389/fmed.2023.1256080 | Huanshun Xiao | https://www.frontiersin.org/articles/10.3389/fmed.2023.1256080/full | The patients infected with omicron during pregnancy often have febrile respiratory symptoms with lymphocyopenia, but the incidence of severe disease is low. Both Omicron infection and gestational diabetes further increase the incidence of cesarean section. | |||||||||||||||||||||
23 | Pregnancy and Infant Outcomes Following SARS-CoV-2 Infection in Pregnancy during Delta Variant Predominance – Surveillance for Emerging Threats to Pregnant People and Infants: Pregnancy and Infant Outcomes during SARS-CoV-2 Delta Variant Predominance | 2023-12-21 | https://doi.org/10.1016/j.ajogmf.2023.101265 | Emily L. REEVES | https://www.sciencedirect.com/science/article/abs/pii/S258993332300407X | In this U.S.-based cohort of persons with SARS-CoV-2 infection in pregnancy, the majority were unvaccinated, and frequencies of stillbirth and preterm birth were higher during the Delta variant predominance period compared to pre-Delta. In the Delta period, frequency of preterm birth and NICU admission was higher among infections occurring in the third trimester versus those earlier in pregnancy. These findings demonstrate population-level increases of adverse fetal and infant outcomes, specifically in the presence of a COVID-19 variant with more severe presentation. | |||||||||||||||||||||
24 | The influence of maternal COVID-19 on cardiac functions: From fetal life to infancy | 2024-01-17 | https://doi.org/10.1111/echo.15736 | Yasemin Özdemir Şahan | https://onlinelibrary.wiley.com/doi/10.1111/echo.15736 | The present case-control study was conducted on 36 pregnant women who had COVID-19 infection in the second trimester of pregnancy and 30 pregnant women as healthy controls. Interventricular septum and left ventricular posterior wall end-diastolic dimensions were significantly higher in the study group in both fetal, neonatal, and infant periods. Impaired diastolic functions of right and left ventricles were detected and myocardial performance indexes with tissue doppler imaging of both lateral walls and septum were significantly higher than controls at all periods. Maternal COVID-19 seems to have a global impact on the cardiac functions of babies in the short and mid-term periods after maternal recovery. | |||||||||||||||||||||
25 | Maternal COVID-19 Infection and Intrauterine Fetal Death: Impact on the Placenta and Fetus | 2024-01-20 | https://doi.org/10.1016/j.prp.2024.155139 | Preethi Muthusamy Sundar | https://www.sciencedirect.com/science/article/abs/pii/S0344033824000505 | Extensive gross placental lesions, mixture of histologic features (maternal/ fetal vascular malperfusion) and isolated cases of massive perivillous fibrin depositon and chronic intervillositis were observed in COVID-IUFD (intrauterine fetal death) group. These results show that SARS-CoV-2 infection results in rapid placental deterioration and fetal death. | |||||||||||||||||||||
26 | Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study | 2024-01-24 | https://doi.org/10.1038/s41467-023-44549-5 | Olivia M. Man | https://www.nature.com/articles/s41467-023-44549-5 | Unusually high rates of RD (Respiratory Distress) are observed in SEU (SARS-CoV-2 exposed uninfected) infants (17%). The odds ratio of RD is 3.06 (95% CI:1.08-10.21) in term neonates born to unvaccinated individuals versus those born to individuals vaccinated prior to maternal infection. | |||||||||||||||||||||
27 | COVID-19 during pregnancy alters circulating extracellular vesicle cargo and their effects on trophoblast | 2024-02-19 | https://doi.org/10.1101/2024.02.17.580824 | Thea N. Golden | https://www.biorxiv.org/content/10.1101/2024.02.17.580824v1 | Circulating extracellular vesicles are altered by COVID-19 during pregnancy and contribute to placental dysfunction. | |||||||||||||||||||||
28 | Pregnant individuals with uncomplicated pregnancies display pro-inflammatory immune changes when exposed to the COVID-19 pandemic | 2024-02-20 | https://doi.org/10.1111/aji.13828 | Elsa Bernier | https://onlinelibrary.wiley.com/doi/10.1111/aji.13828 | Overall, we observed a pro-inflammatory bias in the circulation of pregnant individuals exposed to the COVID-19 pandemic, with otherwise uncomplicated pregnancies. Our work also supports an association between the increased risk of endothelial activation/hypertension and SARS-CoV2 infection. | |||||||||||||||||||||
29 | Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection | 2024-02-23 | https://doi.org/10.3349/ymj.2023.0309 | Manggala Pasca Wardhana | https://eymj.org/DOIx.php?id=10.3349/ymj.2023.0309 | We observed that SARS-CoV-2 infection was able to reach the placenta based on the positive results in the viral and entry receptor immunohistochemistry analyses of the samples. Moreover, the alteration of the inflammatory and apoptosis processes from the histopathological analysis was also found in the infected placenta. The inflammatory conditions and placental damage demonstrated in this study showed that pregnancy had a unique and vulnerable impact owing to SARS-CoV-2 infection. Although the short-term impact on perinatal health was not found in this study, the possibility of the long-term impact of the feto-maternal outcome will require additional attention. | |||||||||||||||||||||
30 | SARS-CoV-2 infection negatively impacts on the quality of embryos by delaying early embryonic development | 2024-03-05 | https://doi.org/10.1111/aji.13831 | Linna Ma | https://onlinelibrary.wiley.com/doi/10.1111/aji.13831 | SARS-CoV-2 infection reduced the number of oocytes and high-quality embryos on day 3. It delays the early embryonic development from the six-cell stage to blastocyst stage and has a negative impact on the quality of embryos. | |||||||||||||||||||||
31 | Correlation between COVID-19 infection and fetal situs inversus | 2024-03-05 | https://doi.org/10.1002/bdr2.2324 | Shuo Qiu | https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2324 | Our analysis showed a strong link between COVID-19 and a higher risk of fetus situs inversus (P < .001, odds ratio 8.196). Maternal COVID-19 infection in the early stages of the pregnancy is associated with an increased risk of fetal situs inversion occurrence. Therefore, further research in this field seems necessary. | |||||||||||||||||||||
32 | SARS-CoV-2 infection by trimester of pregnancy and adverse perinatal outcomes: a Mexican retrospective cohort study | 2024-04-12 | https://doi.org/10.1136/bmjopen-2023-075928 | https://www.ncbi.nlm.nih.gov/pubmed/38604636 | Rakesh Ghosh | https://pubmed.ncbi.nlm.nih.gov/38604636/ | We found that those with mild COVID-19 had an RR of 0.89 (95% CI 0.80 to 0.99) for PTB (preterm birth) and those with severe COVID-19 had an RR of 1.53 (95% CI 1.07 to 2.19) for LGA (large-for-gestational age). COVID-19 in the first trimester was associated with fetal death, RR=2.36 (95% CI 1.04, 5.36). | ||||||||||||||||||||
33 | CCN1-Mediated Signaling in Placental Villous Tissues after SARS-CoV-2 Infection in Term Pregnant Women: Implications for Dysregulated Angiogenesis | 2024-04-18 | https://doi.org/10.3390/cimb46040221 | Yuyang Ma | https://www.mdpi.com/1467-3045/46/4/221 | CCN1 was significantly elevated in the placentas of term pregnant women infected with SARS-CoV-2. By activating a cascade of inflammatory responses, CCN1 induced the production of the anti-angiogenic factors sFlt-1 and sEng, which may lead to abnormal placental vascular architecture. | |||||||||||||||||||||
34 | Increased risk of fetal left–right asymmetry disorders associated with maternal SARS-CoV-2 infection during the first trimester | 2024-05-19 | https://doi.org/10.1038/s41598-024-61778-w | Yang Li | https://www.nature.com/articles/s41598-024-61778-w | This case–control study found that SARS-CoV-2 infection (96.67% vs 3.33%, P = .026) and infection during the first trimester (96.55% vs 3.45%, P = .008) were identified as risk factors. The odds ratio values were 10.545 (95% CI 1.227, 90.662) and 13.067 (95% CI 1.467, 116.419) respectively. SARS-CoV-2 infection during the first trimester significantly increases the risk of fetal LR asymmetry disorders, particularly when the infection occurs between 5 and 6 gestation weeks. The most common associated malformation is heart malformation. | |||||||||||||||||||||
35 | Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero | 2024-05-24 | https://doi.org/10.1038/s41598-024-61918-2 | Viviana Fajardo-Martinez | https://www.nature.com/articles/s41598-024-61918-2 | Children exposed to antenatal COVID-19 have a tenfold higher frequency of DD (developmental delays) as compared to controls and should be offered neurodevelopmental follow-up. | |||||||||||||||||||||
36 | COVID-19 is associated with early emergence of preeclampsia: results from a large regional collaborative | 2024-05-26 | https://doi.org/10.1080/14767058.2024.2345852 | Yasmin G. Hasbini | https://www.tandfonline.com/doi/full/10.1080/14767058.2024.2345852 | SARS-CoV-2 infection during pregnancy increased the risk of preeclampsia [adjusted aRR = 1.69 (1.26–2.26)], preeclampsia involving placental lesions [aRR = 1.97(1.14–3.4)] and preterm preeclampsia 2.48(1.48–4.17). Although the highest rate of preeclampsia was observed in patients infected with SARS-CoV-2 who were symptomatic (18.4%), there was increased risk even in asymptomatic SARS-CoV-2 infected patients (14.2%) relative to non-infected controls (8.7%) (p < 0.05). | |||||||||||||||||||||
37 | Association of antenatal or neonatal SARS-COV-2 exposure with developmental and respiratory outcomes, and healthcare usage in early childhood: a national prospective cohort study | 2024-06-01 | https://doi.org/10.1016/j.eclinm.2024.102628 | Rebecca Jackson | https://www.sciencedirect.com/science/article/pii/S2589537024002074 | SARS-CoV-2 exposure was associated with increased risk of delayed personal-social skills (odds ratio = 3.81; 95% CI: 1.07–13.66), higher ASQ:SE-2 total z-scores (difference in mean z-score = 0.4; 95% CI: 0.2–0.6) and increased risk of delayed social-emotional development (OR = 3.58, 95% CI: 1.30–9.83), after adjusting for sex, age at assessment, parental education, ethnicity and IMD quintile. The exposed cohort had a higher mean total LRSQ z-score than the comparison cohort (0.3 95% CI: 0–0.6) and higher inpatient (38% vs. 21%, p = 0.0001), outpatient (38% vs. 30%, p = 0.0090), and General Practitioner appointments (60% vs. 50%, p = 0.021) than the comparison cohort. | |||||||||||||||||||||
38 | COVID-19 as a risk factor for hypertensive disorders of pregnancy: A retrospective cohort study | 2024-06-11 | https://doi.org/10.1002/rfc2.95 | Hannah Childs | https://onlinelibrary.wiley.com/doi/10.1002/rfc2.95 | COVID-19 was determined to be a risk factor for combined hypertensive disorders of pregnancy (odds ratio [OR] 1.93, 95% confidence interval [CI]: 1.39–2.66) and pre-eclampsia specifically (OR 2.01, 95% CI 1.38–2.88). COVID infection was associated with an increased risk of maternal ICU admission (p = 0.003), and prolonged hospital stay (p < 0.001) both before and after multivariate analysis. | |||||||||||||||||||||
39 | SARS-CoV-2 Infection during Delivery Causes Histopathological Changes in the Placenta | 2024-07-02 | https://doi.org/10.3390/diseases12070142 | Jędrzej Borowczak | https://www.mdpi.com/2079-9721/12/7/142 | SARS-CoV-2 is associated with pathological changes in the placenta, including trophoblast necrosis, calcification, and accelerated villous maturation. Newborns from the research group have lower weights and Apgar scores than healthy newborns. In the COVID-19 group, calcifications and collapsed intervillous space were more frequent, and inflammation was more severe than in the healthy group. At the same time, the placenta of SARS-CoV-2-positive patients showed signs of accelerated vascular maturation. | |||||||||||||||||||||
40 | Multisystem inflammatory syndrome in neonates (MIS-N): an updated systematic review | 2024-07-03 | https://doi.org/10.3389/fped.2024.1382133 | Divya Muthiah | https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1382133/full | MIS-N is a distinct post-infectious immune-mediated syndrome in infants born to mothers with SARS-CoV-2 infection contracted during pregnancy Over two-thirds (144/201, 71.6%) presented with respiratory distress, while 112 (55.7%) had cardiac involvement, such as ventricular dysfunctions, involvement of coronary arteries, and atrioventricular blocks. All neonates, except one, required critical care; 64/160 (40.0%) required inotropic support and 105/187 (56.1%) required respiratory support, of whom 59/105 (56.2%) were specified to require intubation. The mortality rate was 5.0% (10/201). | |||||||||||||||||||||
41 | Variability in COVID-19 Symptom Presentation During Pregnancy and its Impact on Maternal and Infant Outcomes Across the Pandemic | 2024-07-05 | https://doi.org/10.1016/j.ijid.2024.107157 | Julia Günther | https://www.sciencedirect.com/science/article/pii/S1201971224002285 | With the progression of the Wild-type/Alpha to the Delta variant neonatal outcomes worsened. Dyspnea and fever were strong predictors for maternal ICU admission and preterm birth independent of vaccination status or trimester of infection onset. | |||||||||||||||||||||
42 | Post–Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) After Infection During Pregnancy | 2024-07-11 | https://doi.org/10.1097/AOG.0000000000005670 | Metz, Torri D. | https://journals.lww.com/greenjournal/abstract/9900/post_acute_sequelae_of_severe_acute_respiratory.1108.aspx | The prevalence of PASC at a median time of 10.3 months after SARS-CoV-2 infection during pregnancy was 9.3% in the NIH RECOVER-Pregnancy Cohort. The predominant symptoms were postexertional malaise, fatigue, and gastrointestinal symptoms. | |||||||||||||||||||||
43 | The effect of long-term COVID-19 infection on maternal and fetal complications: a retrospective cohort study conducted at a single center in China | 2024-07-27 | https://doi.org/10.1038/s41598-024-68184-2 | Yang Yao | https://www.nature.com/articles/s41598-024-68184-2 | Pregnant individuals who developed long-term COVID-19 during their pregnancy had an increased risk of experiencing gestational hypertension (OR 3.344), gestational diabetes mellitus (OR 2.301), and fetal intrauterine growth restriction (OR 2.817). | |||||||||||||||||||||
44 | Association between situs inversus and maternal SARS-CoV-2 infection at gestational age 4–6 weeks | 2024-08-01 | https://doi.org/10.1016/j.medj.2024.07.009 | Zhenming Guo | https://www.cell.com/med/abstract/S2666-6340(24)00291-5 | Increased risk of fetal situs inversus is significantly associated with maternal SARS-CoV-2 infection at gestational weeks 4–6, corresponding to the fetal developmental window for visceral lateralization in humans. Fetal situs inversus was significantly associated with SARS-CoV-2 infection specifically in gestational weeks 4–6 (adjusted odds ratio [aOR] 6.54 [95% confidence interval 1.76–24.34]), but not with infection at other gestational ages, after adjusting for covariates. | |||||||||||||||||||||
45 | Comparison of Maternal and Infant Outcomes in SARS-CoV-2 Infected Pregnancies and Contemporaneous General Population Pregnancies from British Columbia | 2024-08-06 | https://doi.org/10.1016/j.jogc.2024.102631 | Winnie Fu | https://www.sciencedirect.com/science/article/pii/S1701216324004547 | The study period included deliveries between March 1, 2020 – March 31, 2021. This study demonstrated that SARS-CoV-2 infected pregnancies prior to widespread vaccination, with the early variants, had higher odds of adverse pregnancy outcomes. | |||||||||||||||||||||
46 | Retrospective Analysis of the Impact of SARS-CoV-2 (COVID-19) on Pregnancy and Neonatal Outcomes | 2024-08-06 | https://doi.org/10.1155/2024/1177119 | Leyla Sero | https://onlinelibrary.wiley.com/doi/10.1155/2024/1177119 | While COVID-19 infection in pregnancy seriously affects mortality and morbidity in pregnant women, it also causes mortality and morbidity on the fetus. A total of 23 live-born babies (7.5%) were classified as small for gestational age (SGA), while 80 babies (26.1%) were born before 37 weeks of gestation, and 32 babies (10.4%) were born before 32 weeks. A considerable number of infants, 119 (40.3%), were admitted to the neonatal intensive care unit (NICU). | |||||||||||||||||||||
47 | Effects of Maternal SARS-CoV-2 Infection During Pregnancy on Fetal Development | 2024-08-08 | https://doi.org/10.1111/aji.13911 | Jianan Li | https://onlinelibrary.wiley.com/doi/10.1111/aji.13911 | SARS-CoV-2 infection during pregnancy activates the maternal–fetal immune interface through vertical transmission, and has short- and long-term effects on fetal development, including the central nervous system. | |||||||||||||||||||||
48 | In Situ Analyses of Placental Inflammatory Response to SARS-CoV-2 Infection in Cases of Mother–Fetus Vertical Transmission | 2024-08-13 | https://doi.org/10.3390/ijms25168825 | Denise Morotti | https://www.mdpi.com/1422-0067/25/16/8825 | We found significant differences in gene expression between the placentae of COVID-19-affected mother/newborn pairs and controls. Affected placentae showed significant changes in 305 genes (padj < 0.05) or 219 genes (padj < 0.01). Genes involved in cell signaling (e.g., CCL20, C3, MARCO), immune response (e.g., LILRA3, CXCL10, CD48, CD86) and the high expression of IL1RN, IL-8 and LILRA3 in Group 1 suggest their role in the inflammatory response to SARS-CoV-2. | |||||||||||||||||||||
49 | SARS-CoV-2 replicates in the placenta after maternal infection during pregnancy | 2024-08-14 | https://doi.org/10.3389/fmed.2024.1439181 | Anda-Petronela Radan | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1439181/abstract | The measured scores of SARS-CoV-2 glycoprotein, nucleocapsid, and antisense strand indicating replication correlated with both the severity of maternal symptoms and presence of stillbirth. Intensity of placental viral replication as well as viral levels were higher in women with severe or critical COVID-19 disease, supporting the rationale that severity of maternal SARS-CoV-2 infection could correlate with the severity of placentitis. Replication was maximal in cases of stillbirth, which suggests direct placental involvement in the pathophysiology of this dramatic outcome. | |||||||||||||||||||||
50 | COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study | 2024-08-26 | https://doi.org/10.1016/j.lanepe.2024.101037 | Elena Raffetti | https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(24)00204-7/fulltext | Pregnant women with a COVID-19 diagnosis have higher risks of adverse pregnancy outcomes. COVID-19 diagnosis was associated with a higher risk of gestational diabetes (adjusted HR 1.22, 95% CI 1.18–1.26), gestational hypertension (1.16, 1.10–1.22), pre-eclampsia (1.20, 1.12–1.28), preterm birth (1.63, 1.57–1.69, and 1.68, 1.61–1.75 for spontaneous preterm), very preterm birth (2.04, 1.86–2.23), small for gestational age (1.12, 1.07–1.18), thrombotic venous events (1.85, 1.56–2.20) and stillbirth (only within 14-days since COVID-19 diagnosis, 3.39, 2.23–5.15). | |||||||||||||||||||||
51 | Fecal shedding of SARS-CoV-2 in infants born to SARS-CoV-2 positive mothers: a pilot study | 2024-08-27 | https://doi.org/10.7717/peerj.17956 | Dylan K.P. Blaufus | https://peerj.com/articles/17956/ | Fecal shedding of SARS-CoV-2 occurs in infants who test negative on nasal swabs and is associated with differences in the gut microbiome. Of the 10 included infants, nine were tested for SARS-CoV-2 by nasal swab with 1 testing positive. Four infants, including the nasal swab positive infant, had at least one sample with detectable levels of SARS-CoV-2 fecal shedding. Detection of both SARS-CoV-2 genes in feces was associated with increased gut alpha diversity. | |||||||||||||||||||||
52 | A prospective cohort study of pregnancy outcomes following antepartum infection with SARS-CoV-2 | 2024-08-29 | https://doi.org/10.1016/j.preghy.2024.101152 | James D. Doss | https://www.sciencedirect.com/science/article/abs/pii/S221077892400179X | Exposed patients were significantly more likely to be diagnosed with a hypertensive disorder (aOR 2.3, 95 % CI 1.2–4.1), specifically gestational hypertension (aOR 2.8, 95 % CI 1.3––6.0), but not preeclampsia/eclampsia. There was no difference in rates of preterm birth between exposed and unexposed cohorts (14.6 % vs 11.3 %), in deliveries < 34 weeks (1.5 % vs 2.7 %), PPROM, (0.4 % vs 1.3 %), or gestational age at delivery (38.1 vs 38.2). | |||||||||||||||||||||
53 | The impact of COVID-19 infections on pregnancy outcomes in women | 2024-08-29 | https://doi.org/10.1186/s12884-024-06767-7 | Ke Xu | https://link.springer.com/article/10.1186/s12884-024-06767-7 | This study, based on a cumulative evaluation and analysis of research data from various countries, indicates that pregnant women diagnosed with COVID-19 might have higher rates of preterm birth, cesarean delivery, and low birth weight in newborns compared to those not infected with COVID-19. | |||||||||||||||||||||
54 | Clinical characteristics, outcomes and persistent symptoms of pregnant women with COVID-19: A retrospective cohort study | 2024-08-30 | https://doi.org/10.1002/ijgo.15883 | Ana Paula Orlandi Ghizzoni | https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.15883 | The findings of the present study suggest that COVID-19 was associated with increased morbidity and mortality among pregnant women. In addition, pregnant women with SARS-CoV-2 infection were at significantly higher risk of adverse perinatal outcomes, especially preterm birth. | |||||||||||||||||||||
55 | SARS-CoV-2 replicates in the placenta after maternal infection during pregnancy | 2024-09-03 | https://doi.org/10.3389/fmed.2024.1439181 | Anda-Petronela Radan | https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1439181/full | Intensity of placental viral replication as well as viral levels were higher in women with severe or critical COVID-19 disease, supporting the rationale that severity of maternal SARS-CoV-2 infection could correlate with the severity of placentitis. Replication was maximal in cases of stillbirth, which suggests direct placental involvement in the pathophysiology of this dramatic outcome. | |||||||||||||||||||||
56 | Trends in the Incidence of Hypertensive Disorders of Pregnancy Among the Medicaid Population before and During COVID-19 | 2024-09-06 | https://doi.org/10.1089/whr.2024.0045 | Jessica Lin | https://www.liebertpub.com/doi/10.1089/whr.2024.0045 | The incidence of HDP increased from 10.5% in 2016 to 17.7% in 2021. The highest race/ethnicity-specific incidence of HDP was seen in African American women (19.2%), then White women (13.1%), followed by other women (10.7%). HDP remains a very prevalent and significant global health issue, especially in African American women and during the COVID-19 pandemic. | |||||||||||||||||||||
57 | Transplacental Transmission of SARS-CoV-2: A Narrative Review | 2024-09-18 | https://doi.org/10.3390/medicina60091517 | Minh Tien Bui | https://www.mdpi.com/1648-9144/60/9/1517 | Histopathological findings from the infected placentas reveal inflammation, vascular changes, and the evidence of viral particles in placental tissues. Clinical reports indicate an increased risk of preterm birth, intrauterine growth restriction, and neonatal infection in pregnancies affected by COVID-19. | |||||||||||||||||||||
58 | SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss | 2024-09-19 | https://doi.org/10.1186/s12884-024-06800-9 | Maureen Chileshe | https://link.springer.com/article/10.1186/s12884-024-06800-9 | SARS-CoV-2 seroprevalence among Mozambican women with perinatal loss was high during the second pandemic year, and there was evidence of vertical transmission in stillbirths. Findings also suggest that maternal SARS-CoV-2 infection may increase the risk of developing PE (pre-eclampsia). | |||||||||||||||||||||
59 | SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids | 2024-09-25 | https://doi.org/10.1101/2024.09.25.614931 | Deepak Kumar | https://www.biorxiv.org/content/10.1101/2024.09.25.614931v1 | Our findings reveal that ORF3a is present in placental tissue from pregnant women infected with SARS-CoV2 and disrupts autophagic flux in placental cell lines and 3D stem-cell-derived trophoblast organoids (SCTOs), impairing syncytiotrophoblast differentiation and trophoblast invasion. Autophagy, a crucial physiological process, plays a vital role in placental development by maintaining cellular homeostasis, and its dysregulation is associated with pregnancy complications such as preterm birth, miscarriage, and growth restrictions | |||||||||||||||||||||
60 | Comparison of One-Year Post-Operative Evolution of Children Born of COVID-19-Positive Mothers vs. COVID-19-Negative Pregnancies Having Congenital Gastrointestinal Malformation and Having Received Proper Parenteral Nutrition during Their Hospital Stay | 2024-09-25 | https://doi.org/10.3390/pediatric16040070 | Timea Elisabeta Brandibur | https://pubmed.ncbi.nlm.nih.gov/39449397/ | In our one-year follow-up study, it was seen that even after surgical correction of congenital gastrointestinal malformations, children born of COVID-19-positive pregnancies can suffer serious growth and developmental delays, and gastrointestinal health issues might be more common. | |||||||||||||||||||||
61 | COVID-19–Associated Hospitalizations and Maternal Vaccination Among Infants Aged <6 Months — COVID-NET, 12 States, October 2022–April 2024 | 2024-09-26 | http://dx.doi.org/10.15585/mmwr.mm7338a1 | Fiona P. Havers | https://www.cdc.gov/mmwr/volumes/73/wr/mm7338a1.htm | COVID-19 can cause severe disease in infants aged <6 months; prevention should focus on ensuring that pregnant persons receive recommended COVID-19 vaccines to protect themselves and their young infants. COVID-19–associated hospitalization rates among infants aged <6 months remain higher than those among any other age group except adults aged ≥75 years. The percentage of hospitalized infants whose mothers had been vaccinated during pregnancy was 18% during October 2022–September 2023 and decreased to <5% during October 2023–April 2024. | |||||||||||||||||||||
62 | Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy | 2024-09-27 | https://doi.org/10.3390/life14101237 | Enrico Apa | https://www.mdpi.com/2075-1729/14/10/1237 | In our study, 26% of children whose questionnaire was available were below the 5th percentile in at least one part of the Word section, with a range from 5 to 12%. A notable finding was the percentage of children with tubal dysfunction in both evaluations, within 2 months of age and around 12 months of age. | |||||||||||||||||||||
63 | COVID-19 in pregnancy: prevalence, management, and outcomes in a single large health system | 2024-09-29 | https://doi.org/10.1080/14767058.2024.2409360 | Anna Schulte | https://www.tandfonline.com/doi/full/10.1080/14767058.2024.2409360 | Symptomatic patients were significantly more likely to require hospitalization and ICU admission with some increase in adverse perinatal outcomes. The rate of preterm birth was significantly higher in positive-symptomatic patients compared to positive-asymptomatic and negative patients (15.7% vs. 9.5% and 9.8%, respectively, p = 0.002). Maternal readmission, administration of corticosteroids for fetal lung maturity, birthweight, and neonatal intensive care unit (NICU) admission were significantly affected by SARS-CoV-2 status. | |||||||||||||||||||||
64 | Impact of COVID-19 in pregnancy on maternal and perinatal outcomes during the Delta variant period: a comparison of the Delta and pre-delta time periods, 2020–2021 | 2024-10-01 | https://doi.org/10.1186/s40748-024-00189-1 | Cherrie Morris | https://mhnpjournal.biomedcentral.com/articles/10.1186/s40748-024-00189-1 | In a public, non-profit health system, from January 2020 to November of 2021, mothers with a diagnosis of COVID-19 during pregnancy, there were more preterm deliveries during the Delta time period, as well as longer length of stay for liveborn babies. Maternal outcomes showed a higher rate of cesarean section (33.8%,49%; p = 0.047), with a higher frequency for worsening maternal condition due to COVID-19 (2.8%, 13.7%; p = 0.016) and association with non-reassuring fetal heart tones as indications for cesarean Sect. (53.8%, 95%; p = 0.008) during the Delta time period. | |||||||||||||||||||||
65 | Maternal infection with SARS-CoV-2 during early pregnancy induces hypoxia at the maternal–fetal interface | 2024-10-07 | https://doi.org/10.1111/cpr.13749 | Xiaohui Shi | https://onlinelibrary.wiley.com/doi/10.1111/cpr.13749 | Our study suggests that early-stage SARS-CoV-2 infection during the first trimester leads to severe hypoxia and aberrant cell metabolism at the maternal–fetal interface which gradually resolves as pregnancy progresses. Nevertheless, these abnormal changes may have long-term implications for maternal–fetal interface development. | |||||||||||||||||||||
66 | Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation | 2024-10-10 | https://doi.org/10.1038/s44318-024-00260-9 | Tamiris Azamor | https://www.embopress.org/doi/full/10.1038/s44318-024-00260-9 | In conclusion, an ORF8-C1q-dependent complement activation pathway was identified in COVID-19-affected pregnancies, likely contributing to fetal inflammation independently of fetal virus exposure. While ~26% of fetal tissues were positive for SARS-CoV-2 RNA, more than 60% of fetal tissues contained SARS-CoV-2 ORF8 proteins, suggesting transplacental transfer of this viral accessory protein. ORF8-positive fetal compartments exhibited increased inflammation and complement activation compared to ORF8-negative COVID-19 pregnancies. | |||||||||||||||||||||
67 | Maternal and Fetal Outcome of COVID-19 Infection among Pregnant Women | 2024-10-12 | https://doi.org/10.3390/medicina60101676 | Eman M. Khalil | https://www.mdpi.com/1648-9144/60/10/1676 | Post-COVID symptoms were more prevalent in patients infected during the third trimester. The adverse outcomes of COVID-19 infection for both mother and fetus were more severe in cases where the infection occurred during the third trimester compared to the second and first trimesters. The number of maternal deaths in the third trimester was higher than in the first and second trimesters (16 (24.2%) vs. no deaths and 16 (24.2%) vs. 1 (4%) deaths, respectively, at p < 0.05). | |||||||||||||||||||||
68 | Time series analysis of comprehensive maternal deaths in Brazil during the COVID-19 pandemic | 2024-10-14 | https://doi.org/10.1038/s41598-024-74704-x | Mary Catherine Cambou | https://www.nature.com/articles/s41598-024-74704-x | Excess maternal deaths and comprehensive maternal deaths at the national level increased by over 92% during the second year of the pandemic, with over one-third of the maternal deaths in 2021 due directly to COVID-19 in pregnancy or in the postpartum period. | |||||||||||||||||||||
69 | Placental pathology in SARS-CoV-2 infected pregnancies: A single-institution retrospective cohort analysis | 2024-10-15 | DOI: 10.3233/NPM-230177 | Le, T. | https://content.iospress.com/articles/journal-of-neonatal-perinatal-medicine/npm230177 | A significant proportion of women with SARS-CoV-2 infection during pregnancy at a single county hospital have inflammatory and vascular placental lesions at birth, raising questions regarding their downstream effects and clinical consequences. Approximately 90% (n = 380/425) of placentas from pregnancies complicated by SARS-CoV-2 infections had placental pathologic lesions, compared to 32% (n = 16/50) of controls. | |||||||||||||||||||||
70 | Does infection with COVID-2019 during labor increase the risk for obstetric anal sphincter injuries? | 2024-10-21 | https://doi.org/10.1002/ijgo.15966 | Alla Saban | https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.15966 | Infection with COVID-19 during the peripartum period significantly increases the risk for OASIS (obstetric anal sphincter injuries) by more than fourfold. Peripartum infection with COVID-19 was found to be independently associated with OASIS (adjusted odds ratio 4.38, 95% confidence interval 2.00–9.61; P < 0.001). | |||||||||||||||||||||
71 | The association of increased incidence of congenital heart disease in newborns with maternal COVID-19 infection during pregnancy | 2024-10-22 | https://doi.org/10.1038/s41598-024-76690-6 | Huimin Ren | https://www.nature.com/articles/s41598-024-76690-6 | Maternal COVID-19 infection during pregnancy may adversely affect the development of the newborn’s heart. A significantly higher prevalence of cardiac ultrasound abnormalities was observed in the COVID-19 group (10.08%) compared to the control group (4.13%, p = 0.012). Further analysis revealed that the majority of cardiac abnormalities in the COVID-19 group occurred in mothers infected before 8 weeks of pregnancy. | |||||||||||||||||||||
72 | Outcomes of COVID-19 in Pregnant Women: A Retrospective Analysis of 300 Cases in Jordan | 2024-10-23 | https://doi.org/10.3390/healthcare12212113 | Hamza Hasan Suliman Al-Amoosh | https://www.mdpi.com/2227-9032/12/21/2113 | The study showed that COVID-19 in pregnant women, particularly in the third trimester, is associated with significant neonatal complications, with age, hospitalization duration, and COVID-19 severity strongly impacting outcomes. The rate of miscarriage among our patients was significant at 6.3%. | |||||||||||||||||||||
73 | Placenta a potential gateway of prenatal SARS-CoV-2 infection: A review | 2024-10-25 | https://doi.org/10.1016/j.ejogrb.2024.10.027 | Subhashis Indra | https://www.sciencedirect.com/science/article/pii/S0301211524005748 | Despite the low likelihood of transplacental transmission of SARS-CoV-2, the virus still poses a significant threat to fetal development. Maternal infection with SARS-CoV-2 triggers a robust immune response, which can cause damage to the placenta. This damage is evident from various histopathological lesions associated with maternal COVID-19. This damage in the placenta associated with SARS-CoV-2 infection might interfere with the normal functioning of the placenta and, thereby, can be detrimental to the fetus's growth and, in severe cases, might lead to intrauterine fetal demise. | |||||||||||||||||||||
74 | Investigating the impact of severe maternal SARS-CoV-2 infection on infant DNA methylation and neurodevelopment | 2024-10-30 | https://doi.org/10.1038/s41380-024-02808-x | Rachel A. Hill | https://www.nature.com/articles/s41380-024-02808-x | Infants exposed to severe SARS-CoV-2 in utero demonstrated over 3000 significant differentially methylated sites within their genomes compared to non-exposed, including genes highly relevant to ASD (Atrial septal defect) and synaptic pathways. At 12 months, severe SARS-CoV-2 exposed infants scored lower on the ASQ-3 (Ages and Stages Questionnaire) than non-exposed infants, and communication and problem-solving scores negatively correlated with maternal IL-6 levels at birth. | |||||||||||||||||||||
75 | The impact of SARS-CoV-2 infection at different stages of pregnancy on placental inflammatory responses | 2024-11-01 | https://doi.org/10.21203/rs.3.rs-5278771/v1 | Mengyue Yin | https://www.researchsquare.com/article/rs-5278771/v1 | SARS-CoV-2 infection during pregnancy appears to have limited impact on overall maternal and fetal outcomes. However, the infection may lead to inflammatory changes in placental tissues, particularly during the mid-trimester. | |||||||||||||||||||||
76 | SARS-CoV-2 infection elucidates features of pregnancy-specific immunity | 2024-11-05 | https://doi.org/10.1016/j.celrep.2024.114933 | Dong Sun Oh | https://www.sciencedirect.com/science/article/pii/S2211124724012841?via%3Dihub | We find that SARS-CoV-2 infection is associated with altered T cell responses in pregnant women, including a clonal expansion of CD4-expressing CD8+ T cells, diminished interferon responses, and profound suppression of monocyte function. We also identify shifts in cytokine and chemokine levels in the sera of pregnant individuals, including a robust increase of interleukin-27, known to drive T cell exhaustion. Our findings reveal nuanced pregnancy-associated immune responses, which may contribute to the increased susceptibility of pregnant individuals to viral respiratory infection. | |||||||||||||||||||||
77 | Examining the Effect of Parental COVID-19 Vaccination Prior to Birth and the Association Between COVID-19 and Cancer in Children Under Six | 2024-11-07 | https://doi.org/10.1002/hpm.3869 | Aflatoonian Behnaz | https://onlinelibrary.wiley.com/doi/10.1002/hpm.3869 | Emphasising vaccination's protective effects before and during pregnancy, the study advocates integrating vaccination into maternal health programs. Chi-square testing confirmed a significant rise in childhood cancer rates post-COVID-19 pandemic compared to pre-pandemic rates. Key factors influencing cancer incidence include the mother's age at childbirth, parental vaccination history before pregnancy, maternal vaccination details during pregnancy, the child's COVID-19 infection status, and maternal marriage age. | |||||||||||||||||||||
78 | How to Manage a Neonate Born from a SARS-CoV-2-Positive Mother: A Narrative Review | 2024-11-08 | https://doi.org/10.3390/pathogens13110977 | Serena Salomè | https://www.mdpi.com/2076-0817/13/11/977 | Both vertical and horizontal transmissions in the neonatal age appear to be less common and have a better prognosis than supposed at the beginning of the pandemic. Nevertheless, the hospital stay of a newborn from positive mother requires specific management protocols that can be difficult to apply in some centers, and the neonatal multisystemic inflammatory syndrome can be challenging to diagnose and manage. Vaccination protects against adverse maternal–fetal outcomes and is now the most effective intervention for improving neonatal morbidity due to SARS-CoV-2 and can be administered at any time during pregnancy. | |||||||||||||||||||||
79 | Maternal COVID-19 infection associated with offspring neurodevelopmental disorders | 2024-11-09 | https://doi.org/10.1038/s41380-024-02822-z | Lian Duan | https://www.nature.com/articles/s41380-024-02822-z | Our findings support a model where the maternal COVID-19 infection changed the levels of CD4 proliferating T cells, leading to the alterations of astrocytes, endothelial cells, and excitatory neurons in offspring, contributing to the increased risk of NDDs (neurodevelopmental disorders) in these individuals. | |||||||||||||||||||||
80 | Does Fever Caused by the COVID-19 Virus Before Labor Increase the Rate of MSAF and Affect Maternal and Fetal Outcomes? | 2024-11-10 | https://doi.org/10.1155/2024/8456910 | Runrun Feng | https://onlinelibrary.wiley.com/doi/10.1155/2024/8456910 | For pregnant women infected with COVID-19, the rate of MSAF (meconium-stained AF) disturbance significantly increases, therefore, it is necessary to pay more attention to fetal heart changes and amniotic fluid conditions, and actively managing labor is beneficial for improving delivery outcomes. A statistically significant association was observed between fever during pregnancy and MSAF, with a higher risk of development observed in fever–pregnant women compared to nonfever ones | |||||||||||||||||||||
81 | COVID-19 and pregnancy: a comprehensive study of comorbidities and outcomes | 2024-11-13 | https://doi.org/10.1186/s12889-024-20416-w | Shang-Ming Zhou | https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-20416-w | PW (Pregnant Women) with COVID-19 infections were more likely to require hospital admission, intubation treatments, and ICU admission compared to NPW (Non-Pregnant Women) with COVID-19. | |||||||||||||||||||||
82 | The association of maternal COVID-19-infection during pregnancy on the neonatal immune profile and associations with later diagnosis of neurodevelopmental disorders | 2024-11-15 | https://doi.org/10.1016/j.bbi.2024.11.014 | Danielle HJ Kim | https://www.sciencedirect.com/science/article/pii/S0889159124006949 | Our results suggest that reduced levels of neonatal immune molecules in newborns of COVID + mothers may be linked to an increased risk of a subsequent diagnosis of an NDD. | |||||||||||||||||||||
83 | SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: A Cohort Study of Pregnant People in a Maternity Hospital in Rio de Janeiro, Brazil | 2024-11-15 | https://doi.org/10.21203/rs.3.rs-5383591/v1 | Michelle de Oliveira Brendolin | https://www.researchsquare.com/article/rs-5383591/v1 | The risk of maternal death due to COVID-19 highlights the need for adequate preventive measures, particularly vaccination, during the prenatal and postpartum periods. Cesarean section deliveries were performed in 54% (135/249) SARS CoV-2 + participants vs 41.7% (391/936) of uninfected, p = < 0.001. Preterm deliveries occurred more frequently in patients testing positive for SARS-CoV-2 (30.7% vs 23.6). Patients infected with SARS-CoV-2 were at greater risk of adverse maternal outcomes (crude HR: 6.12, 95% CI: 3.70-10.14; adjusted HR: 5.60, 95% CI: 3.35–9.37) than uninfected pregnant participants. All 21 participants who died were unvaccinated against COVID-19. | |||||||||||||||||||||
84 | Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis | 2024-11-19 | https://doi.org/10.1186/s12879-024-10161-1 | Muhammed Shabil | https://link.springer.com/article/10.1186/s12879-024-10161-1 | Newborns born to mothers with COVID-19 have a substantially increased risk of developing RDS (respiratory distress syndrome). Newborns from infected mothers had a significantly higher risk of developing RDS, with a pooled risk ratio (RR) of 2.69. | |||||||||||||||||||||
85 | Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes? | 2024-11-21 | https://doi.org/10.1038/s41372-024-02179-9 | Júlia Candel-Pau | https://link.springer.com/article/10.1038/s41372-024-02179-9 | Infants born to mothers with COVID-19 during pregnancy in our hospital showed higher rates of respiratory distress and pathological jaundice, without increased rates of prematurity or other morbidities. We included 2701 neonates and observed higher rates of respiratory distress (5.7% vs 3.3%, p = 0.044) and pathological jaundice (7.7% vs 4.1%, p = 0.007) in the COVID-19 cohort, without differences between trimesters. | |||||||||||||||||||||
86 | Maternal infection of SARS-CoV-2 during the first and second trimesters leads to newborn telomere shortening | 2024-11-21 | https://doi.org/10.1186/s12967-024-05879-0 | Lina Wang | https://link.springer.com/article/10.1186/s12967-024-05879-0 | Maternal SARS-CoV-2 infection at the first and second trimesters leads to significantly shorter TL (Telomere length) and earlier infection causes much more severe TL damage. Shorter TL was observed only if maternal infection of SARS-CoV-2 occurred in the first and second trimesters of pregnancy (1.261 ± 0.340 and 1.346 ± 0.353, respectively). | |||||||||||||||||||||
87 | PD-L1 expression and characterization of its carrier macrophages in placentas with acute and specifically post-SARS-CoV-2 infection | 2024-11-26 | https://doi.org/10.1007/s00418-024-02340-7 | Marina C. Seefried | https://link.springer.com/article/10.1007/s00418-024-02340-7 | The data of our study showed an upregulation of CD163 positive maternal macrophages and a higher PD-L1 expression in acute and post-COVID-19 male placentas. In addition, we identified a significant upregulation of PD-L1 in post-COVID-19 male extravillous trophoblast cells. These post-COVID-19 placental changes could to some degree affect at least the male post-COVID-19 offspring. | |||||||||||||||||||||
88 | Impact of Maternal Stress and COVID-19 Exposure During Pregnancy on Offspring Neurodevelopment: Signature Cohort 12 Month Follow-Up | 2024-12-02 | https://doi.org/10.21203/rs.3.rs-5442190/v1 | Nathalia Garrido-Torres | https://www.researchsquare.com/article/rs-5442190/v1 | In utero exposure to severe COVID-19 infection nearly tripled the risk of developmental concern in the ASQ-3 personal-social subdomain at 12 months follow-up [OR = 2.751 (95% CI 1.065–7.106), p = 0.037], independently of the timing of the infection and maternal stress. | |||||||||||||||||||||
89 | COVID-19 and Pregnancy Outcomes: A Descriptive Study From a Tertiary Hospital in Ras Al Khaimah, UAE | 2024-12-03 | https://doi.org/10.1155/ogi/5252919 | Manal M. Sami | https://onlinelibrary.wiley.com/doi/10.1155/ogi/5252919 | Emergency cesarean delivery was found to be significant (p = 0.0007) in hospitalized patients. COVID-19 pneumonia was the prevailing adverse maternal outcome. NICU admission and prematurity were the most frequent neonatal outcomes. | |||||||||||||||||||||
90 | Maternal oxygenation and fetal-neonatal mortality among patients with COVID-19 requiring advanced respiratory support in ICU: A multicenter prospective cohort study | 2024-12-05 | https://doi.org/10.1002/ijgo.16046 | Daniela N. Vasquez | https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.16046 | A total of 91 patients (pregnant or postpartum patients with COVID-19 pneumonia requiring advanced respiratory support) were admitted to 21 ICUs. Of 71 births, 64 (90%) were preterm. A total of 14 fetal/neonatal losses (14/91;15.4%) occurred. Fetal/neonatal losses were associated with gestational age at delivery, maternal severity of illness on admission. | |||||||||||||||||||||
91 | Cranial ultrasonographic findings in newborns exposed to SARS-CoV-2: a single-centre cross-sectional analysis | 2024-12-05 | https://doi.org/10.1186/s13052-024-01826-3 | Bruna Scalia | https://ijponline.biomedcentral.com/articles/10.1186/s13052-024-01826-3 | The incidence of minor intracranial abnormalities was higher in SARS-COV-2-exposed newborns. cUS (cranial ultrasonographic) abnormalities were found in 32 exposed patients (23%) and in 23 (16.5%) unexposed patients. A statistically significant difference was found in the incidence of minor intracranial abnormalities (p 0.036) between exposed and unexposed patients and between newborns exposed during pregnancy and unexposed patients (p 0.016). | |||||||||||||||||||||
92 | Assessment of the Peripheral and Central Auditory System in Infants Whose Mothers Tested Positive for COVID-19 During Pregnancy | 2024-12-16 | https://doi.org/10.3390/children11121527 | Jheniffer Queiroz Raimundo | https://www.mdpi.com/2227-9067/11/12/1527 | No evidence was found that vertical exposure to COVID-19 causes hearing loss, although there were signs of possible deterioration in hair cell functioning. Despite the absence of cases of hearing loss, there was a prevalence of absent responses at high frequencies in otoacoustic emissions, leading to the possibility that there had been damage to hair cells. Moreover, a decrease in otoacoustic emissions amplitude over time and with increasing frequency was observed. | |||||||||||||||||||||
93 | Assessing the Impact of COVID-19 on Pregnancy and Maternal Outcomes: A Slovak National Study | 2024-12-16 | https://doi.org/10.3390/reprodmed5040028 | Adriána Goldbergerová | https://www.mdpi.com/2673-3897/5/4/28 | While maternal and neonatal outcomes were generally favourable, a slight increase in caesarean sections and preterm births suggests an indirect impact on maternity care. Vaccination during pregnancy correlated with reduced symptoms and no hospitalizations. | |||||||||||||||||||||
94 | The Benefits of COVID-19 Vaccination for Pregnant Patients Hospitalized with Respiratory Symptoms: A Retrospective Cohort Study in South Brazil | 2024-12-22 | https://doi.org/10.3390/vaccines12121445 | Christopher J. Hernandez | https://www.mdpi.com/2076-393X/12/12/1445 | SARS-CoV-2 infection was associated with maternal ventilator support (adjusted Risk Ratio [aRR] = 1.48), while receipt of at least one dose of COVID-19 vaccine was associated with protection against maternal sepsis (aRR = 0.14), intensive care unit (ICU) admission (aRR = 0.27), need for ventilator support (aRR = 0.60), infant admission to the neonatal intensive care unit (NICU) (aRR = 0.62), and neonatal respiratory distress (aRR = 0.60). | |||||||||||||||||||||
95 | Association of SARS-CoV-2 Infection During Pregnancy With Placental Weight and Histopathologic Lesions | 2024-12-25 | https://doi.org/10.1016/j.placenta.2024.12.017 | Regan N. Theiler | https://www.sciencedirect.com/science/article/abs/pii/S0143400424008087 | COVID-19 at any gestational age or severity increases the risk of small placental weight and the presence of placental inflammatory lesions. Inflammatory changes were present in 50% of the placentas examined but did not differ by group, except that acute fetal vasculitis occurred more frequently after asymptomatic vs symptomatic maternal infection (23% vs 5%; risk ratio, 4.62; 95% CI, 1.16-18.30). | |||||||||||||||||||||
96 | COVID-19 reinfection in pregnancy: assessment of Severity and pregnancy outcomes in England | 2024-12-27 | https://doi.org/10.1016/j.jinf.2024.106392 | Anna A Mensah | https://www.sciencedirect.com/science/article/pii/S016344532400327X | Hospital admission after SARS-CoV-2 reinfection was more common in pregnancy, especially during the third trimester (aOR= 18.56; 95% CI: 9.46 - 36.42) and was similar following reinfection or primary infection in pregnancy (aOR= 0.82; 95% CI: 0.50 - 1.33). Pregnant women remain at higher risk of more severe disease during reinfection compared to non-pregnant women yet; hospitalisation and ICU admissions risk were low during the omicron period. | |||||||||||||||||||||
97 | PostCOVID-19 Impact on Perinatal Outcomes | 2024-12-29 | https://doi.org/10.3390/diagnostics15010057 | Gaukhar Kurmanova | https://www.mdpi.com/2075-4418/15/1/57 | The past COVID-19 infection in pregnant women has long-term consequences in the form of placenta abnormal development and oligohydramnios; and, as a result, the development of adverse perinatal outcomes. There is a statistically significant strong association between a history of COVID-19 and the development of oligohydramnios, and medium strength between a history of COVID-19 and the presence of anemia, abnormal development of the placenta, cord entanglement, low birth weight and stillbirth. | |||||||||||||||||||||
98 | Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage | 2024-12-30 | https://doi.org/10.1111/aji.70034 | Guilherme M. Nobrega | https://onlinelibrary.wiley.com/doi/10.1111/aji.70034 | These findings indicate that SARS-CoV-2 infection induces localized focal placental damage, warranting further investigation into its impact on maternal and perinatal outcomes. We found increased secreted SASP (senescence-associated secretory phenotype) markers. Confocal microscopy of placentas from COVID-19 positive cases revealed localized areas of oxidative stress and DNA damage colocalized with SARS-CoV-2 spike protein. | |||||||||||||||||||||
99 | Placental Infection with Different SARS-CoV-2 Variants Leading to Stillbirth: Report of Two Cases | 2025-01-04 | https://doi.org/10.3390/covid5010008 | Miriam A. Snow | https://www.mdpi.com/2673-8112/5/1/8 | Although the COVID-19 pandemic was declared over as of May 2023, the infection remains globally endemic and the risks of pregnancy loss attributable to SARS-CoV-2, albeit low, persist. The data demonstrate that SP (SARS-CoV-2 placental infection), albeit rare, continues to cause intrauterine fetal demise (IUFD) across viral variants regardless of the clinical severity of the infection. | |||||||||||||||||||||
100 | The Effect of COVID-19 on Neonatal Outcomes in a Community Hospital | 2025-01-10 | https://doi.org/10.3390/jcm14020420 | Maria Martinez-Baladejo | https://www.mdpi.com/2077-0383/14/2/420 | This study corroborates the adverse impact of SARS-CoV-2 infection on pregnant women, characterized by increased maternal comorbidities and adverse birth outcomes. Pregnant parturients infected with SARS-CoV-2 exhibited higher rates of GDM (gestational diabetes mellitus), PEC (preeclampsia ), and CS (cesarean section). Lastly, consistent with known obstetrics risks, our PEC population was more likely to have cHTN (chronic hypertension). | |||||||||||||||||||||
101 | Similar Spatial Expression of Immune-Related Proteins in SARS-CoV-2 Placentitis and Chronic Histiocytic Intervillositis | 2025-01-16 | https://doi.org/10.1002/eji.202451386 | Michelle Broekhuizen | https://onlinelibrary.wiley.com/doi/10.1002/eji.202451386 | SARS-CoV-2 placentitis and CHI are associated with enhanced myeloid cell infiltration into the intervillous space, but not in the decidua and villi. The more prominently reduced apoptosis-related protein expression in SARS-CoV-2 placentitis may lead to an exaggerated immune response, causing acute placental dysfunction and fetal demise. | |||||||||||||||||||||
102 | Preterm Birth and SARS-CoV-2: Does a Correlation Exist? | 2025-01-24 | https://doi.org/10.3390/biomedicines13020282 | Federica Perelli | https://www.mdpi.com/2227-9059/13/2/282 | Preventing SARS-CoV-2 infection during pregnancy is crucial to mitigate adverse obstetric outcomes. The average incidence rate of preterm birth in infected patients was 18.5%, with a median of 12.75%, while non-infected women showed an average incidence of preterm birth of 10%, with a median of 8.2%. | |||||||||||||||||||||
103 | Understanding the Potential Impact of Trimester-Specific Maternal Immune Activation due to SARS-CoV-2 on Early Human Neurodevelopment and the Role of Cytokine Balance | 2025-01-24 | https://doi.org/10.1016/j.bbih.2025.100956 | Alexandre Díaz-Pons | https://www.sciencedirect.com/science/article/pii/S2666354625000146 | Control infants performed better in some NBAS items. However, cases infants showed trimester-specific differences. First-trimester exposure was related to motor and reflex delays, second-trimester to poorer performances in motor tasks and autonomic stability, and third-trimester to weaker state organization, regulation, and reflexes. | |||||||||||||||||||||
104 | Hemostatic Profile and Serum Levels of Interferon Gamma-Induced Protein 10 (IP-10) in Neonates Born to Mothers with COVID-19 During the Peripartum Period | 2025-01-30 | https://doi.org/10.3390/ijms26031201 | Rozeta Sokou | https://www.mdpi.com/1422-0067/26/3/1201 | Multiple linear regression analysis revealed that peripartum COVID-19 infection was associated with higher IP-10 levels in neonates (coefficient: +16.8, 95% CI: +9.0 to +24.6, p < 0.0001). Our study findings suggest that the presence of immunologic disturbance in neonates is related to recent peripartum exposure to maternal SARS-CoV-2 infection, as evidenced by increased IP-10 levels in blood samples obtained from neonates born to SARS-CoV-2-positive mothers. | |||||||||||||||||||||
105 | SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil | 2025-01-31 | https://doi.org/10.3390/v17020207 | Michelle Brendolin | https://www.mdpi.com/1999-4915/17/2/207 | Intensive care unit admission and/or death occurred in 68 of 1185 participants (5.7%), 44 of 249 participants (17.7%) infected with SARS CoV-2 vs. 24 of 936 uninfected participants (2.5%). All 21 participants who died were unvaccinated against COVID-19. Women infected with SARS-CoV-2 were at greater risk of adverse maternal outcomes (crude HR: 5.93, 95% CI: 3.58–9.84; adjusted HR: 5.47, 95% CI: 3.16–9.48) than uninfected pregnant women. | |||||||||||||||||||||
106 | SARS-CoV-2 infection in pregnant women and incidence of thromboembolic disease – an analysis of the Covid-19 Related Obstetric and Neonatal Outcome Study (CRONOS) in Germany | 2025-02-10 | https://doi.org/10.21203/rs.3.rs-5911006/v1 | Ulrich Pecks | https://www.researchsquare.com/article/rs-5911006/v1 | Data from 8033 pregnant patients showed 40 TEs (thromboembolic events) (0.5% incidence). TE rates were 10% in ICU patients, 0.2–0.4% in those with moderate-to-mild COVID-19, and < 0.1% in asymptomatic women. Risk factors included advanced gestational age, COVID-19 symptoms, hospitalization or ICU admission, premature birth, cesarean section, delivery within 4 weeks of infection, higher weight gain, anemia, and chronic inflammatory bowel disease. COVID-19 vaccination reduced risk. | |||||||||||||||||||||
107 | Any neonatal morbidityAdverse perinatal outcomes of unvaccinated pregnant women with respiratory symptoms during the COVID-19 pandemic: Evidence from a Brazilian multicenter study | 2025-02-14 | https://doi.org/10.1002/ijgo.70010 | Juliana Da-Costa-Santos | https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.70010 | Severe maternal illness was strongly associated with APO (adverse perinatal outcomes) regardless of COVID-19 confirmation. It is essential to provide sufficient and timely health care for women who have respiratory symptoms compatible with COVID-19. | |||||||||||||||||||||
108 | SARS-CoV-2 compromises blastocyst quality by modifying the ovarian microenvironment | 2025-02-18 | https://doi.org/10.1038/s41392-025-02156-4 | Chen Geng | https://www.nature.com/articles/s41392-025-02156-4 | Our finding highlights the complex influence on oocyte competency of gene expressions, including ISG15 and MX1, and alterations in metabolites and lipids. Overall, after SARS-CoV-2 infection, increased IFN-β levels in FF (follicular fluid) stimulated MX1 and ISG15 expression. Both ISG15 and MX1, along with elevated levels of sn-glycerol-3-phosphoethanolamine and WE (49:12) + H, negatively impacted blastocyst quality. | |||||||||||||||||||||
109 | The impact of acute and prior SARS-CoV-2 infection on maternal and neonatal outcomes in pregnant women: a single-center retrospective cohort study | 2025-02-18 | https://doi.org/10.1186/s12884-025-07301-z | Yujie Tang | https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-025-07301-z | Pregnant women at delivery with acute SARS-CoV-2 infection were associated with higher risk of ICP (intrahepatic cholestasis of pregnancy), preterm birth, fetal distress, primary cesarean delivery and neonatal unit admission. Prior SARS-CoV-2 infection during pregnancy was associated with higher risk ICP. | |||||||||||||||||||||
110 | SARS-CoV-2 Infection and Its Association with Maternal and Fetal Redox Status and Outcomes: A Prospective Clinical Study | 2025-02-26 | https://doi.org/10.3390/jcm14051555 | Marija Bicanin Ilic | https://www.mdpi.com/2077-0383/14/5/1555 | This study confirmed the significant impact of the SARS-CoV-2 viral infection on maternal and fetal biochemical parameters and oxidative stress-mediated placental dysfunction. The values of the superoxide anion radical and index of lipid peroxidation were significantly different in mothers concerning the presence of the SARS-CoV-2 infection, while the levels of the nitric oxide, index of lipid peroxidation, reduced glutathione, and superoxide dismutase were significantly different in the newborns depending on the SARS-CoV-2 infection. |
| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | AA | |
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1 | Study Title | Date | DOI | PMCID | Lead Author | Link | Quote | ||||||||||||||||||||
2 | Count of studies: | 46 | |||||||||||||||||||||||||
3 | Reinfections with Different SARS-CoV-2 Omicron Subvariants, France | 2022-09-23 | https://doi.org/10.3201/eid2811.221109 | Nhu Ngoc Nguyen | https://wwwnc.cdc.gov/eid/article/28/11/22-1109_article | We identified 188 (0.7%) cases of reinfection out of 27,972 patient samples that tested positive for the SARS-CoV-2 Omicron variant during November 28, 2021–July 22, 2022... The median time between the primary and secondary infections was 146 days (range 7–214 days). In 50/188 (26.6%) patients, time between the 2 infections was <90 days and, in 28/188 (14.9%) patients, the time was <60 days between the 2 infections. | |||||||||||||||||||||
4 | Acute and postacute sequelae associated with SARS-CoV-2 reinfection | 2022-11-10 | https://doi.org/10.1038/s41591-022-02051-3 | Bowe, B. | https://www.nature.com/articles/s41591-022-02051-3 | Compared to no reinfection, reinfection contributed additional risks of death (hazard ratio (HR) = 2.17, 95% confidence intervals (CI) 1.93–2.45), hospitalization (HR = 3.32, 95% CI 3.13–3.51) and sequelae including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders. The risks were evident regardless of vaccination status. The risks were most pronounced in the acute phase but persisted in the postacute phase at 6 months. | |||||||||||||||||||||
5 | Risk factors for long COVID among healthcare workers, Brazil, 2020–2022 | 2023-01-05 | https://doi.org/10.1101/2023.01.03.22284043 | Alexandre R. Marra | https://www.medrxiv.org/content/10.1101/2023.01.03.22284043v1 | Factors associated with development of long COVID were female sex (OR 1.21 [CI95 1.05-1.39]) and two or more COVID-19 infections (1.27 [CI95 1.07-1.50]). Those receiving four COVID-19 vaccine doses prior to infection (OR 0.05 [CI95 0.01-0.19]) were significantly less likely to develop long COVID. | |||||||||||||||||||||
6 | SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study | 2023-01-05 | https://doi.org/10.1101/2023.01.03.22284042 | Emily Hadley | https://www.medrxiv.org/content/10.1101/2023.01.03.22284042v1 | The total proportion of individuals requiring an ED visit or hospitalization or passing away is similar between first infection and reinfection. The largest proportion of Long COVID diagnoses occur among individuals with a first reinfection in the Omicron BA epoch. Long COVID diagnoses also occurred much closer to the index date following both initial or first reinfection in the Omicron BA epoch as compared to earlier Delta and Omicron epochs. The rate of Long COVID diagnoses has been increasing for reinfections in more recent variants | |||||||||||||||||||||
7 | Lower prevalence of Post-Covid-19 Condition following Omicron SARS-CoV-2 infection | 2023-04-05 | https://doi.org/10.1101/2023.04.05.23288157 | Siméon De Bruijn | https://www.medrxiv.org/content/10.1101/2023.04.05.23288157v1 | Three months after Omicron, prevalence of PCC (Post-COVID condition) is 41% lower than after Delta. Reinfection seems associated with more prevalent severe long-term symptoms compared to a first infection. A booster prior to infection does not seem to improve the outcome of long-term symptoms. | |||||||||||||||||||||
8 | SARS-CoV-2 Reinfection and Severity of the Disease: A Systematic Review and Meta-Analysis | 2023-04-14 | https://doi.org/10.3390/v15040967 | Nhu Ngoc Nguyen | https://www.mdpi.com/1999-4915/15/4/967 | No significant differences of clinical pattern were observed between primary infection and reinfection. No significant differences in the severity of infection were observed between primary infection and reinfection. Being female, being a patient with comorbidities, lacking anti-nucleocapsid IgG after the first infection, being infected during the Delta and Omicron wave, and being unvaccinated were associated with a higher risk of reinfection. Reinfection with SARS-CoV-2 suggests that natural immunity is not long-lasting in COVID-19 patients. | |||||||||||||||||||||
9 | Risk of new-onset Long Covid following reinfection with SARS-CoV-2: community-based cohort study | 2023-04-17 | https://doi.org/10.1101/2023.04.13.23288522 | Matthew L. Bosworth | https://www.medrxiv.org/content/10.1101/2023.04.13.23288522v1 | The risk of new-onset Long Covid after a second SARS-CoV-2 infection is lower than that after a first infection for those ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset Long Covid after a second infection, with around 1 in 40 of those ≥16 years and 1 in 165 of those <16 years reporting Long Covid after a second infection. | |||||||||||||||||||||
10 | Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection | 2023-05-25 | https://doi.org/10.1001/jama.2023.8823 | Tanayott Thaweethai | https://jamanetwork.com/journals/jama/fullarticle/2805540 | In the Omicron cohorts, the estimated proportion of PASC positivity was greater among reinfected participants compared with participants with 1 reported infection (acute Omicron: 20% vs 9.7%; postacute Omicron: 21% vs 16%). | |||||||||||||||||||||
11 | Trends in Laboratory-Confirmed SARS-CoV-2 Reinfections and Associated Hospitalizations and Deaths Among Adults Aged ≥18 Years — 18 U.S. Jurisdictions, September 2021–December 2022 | 2023-06-23 | http://dx.doi.org/10.15585/mmwr.mm7225a3 | Kevin C. Ma | https://www.cdc.gov/mmwr/volumes/72/wr/mm7225a3.htm?ftag=YHF4eb9d17 | During September 2021–December 2022, the percentages of reinfections among all COVID-19 cases, hospitalizations, and deaths reported by 18 U.S. jurisdictions increased substantially as new Omicron lineages became predominant. Increases were more pronounced among adults aged 18–49 years compared with those among older persons. | |||||||||||||||||||||
12 | Longitudinal study of humoral immunity against SARS-CoV-2 of health professionals in Brazil: the impact of booster dose and reinfection on antibody dynamics | 2023-07-14 | https://doi.org/10.3389%2Ffimmu.2023.1220600 | https://pubmed.ncbi.nlm.nih.gov/37520570 | Ana Paula Moreira Franco-Luiz | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376701/ | Overall, our data indicate that acquired humoral immunity declines over time and suggests that IgM and IgG antibody levels are not associated with the prevention of reinfection. | ||||||||||||||||||||
13 | Influence of Prior SARS-CoV-2 Infection | 2023-08-06 | https://doi.org/10.1101/2023.08.03.23293612 | Nathaniel Hendrix | https://www.medrxiv.org/content/10.1101/2023.08.03.23293612v1 | Overall, prior infection was associated with a significant slightly elevated risk of severe disease. As the pandemic proceeded, the effect of prior infection tended to evolve from generally protective during the pre-Omicron era to unprotective during the Omicron era. | |||||||||||||||||||||
14 | Predicting Clinical Outcomes of SARS-CoV-2 Infection During the Omicron Wave Using Machine Learning | 2023-08-09 | https://doi.org/10.1101/2023.08.06.23293725 | Steven Cogill | https://www.medrxiv.org/content/10.1101/2023.08.06.23293725v1 | Machine learning models demonstrated that advanced age, high comorbidity burden, lower body mass index, unvaccinated status, prior SARS-CoV-2 infection, and oral anticoagulant use were the important predictors of hospitalization and escalation of care. Similar factors predicted death. | |||||||||||||||||||||
15 | SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic | 2023-08-19 | https://doi.org/10.3390/ijms241612962 | Fotini Boufidou | https://www.mdpi.com/1422-0067/24/16/12962 | The cumulative risk of long COVID as well as of various cardiac, pulmonary, or neurological complications increases proportionally to the number of SARS-CoV-2 infections, primarily in the elderly. Therefore, the number of long COVID cases is expected to remain high in the future. Reinfections apparently increase the likelihood of long COVID, but less so if they are mild or asymptomatic as in children and adolescents. | |||||||||||||||||||||
16 | Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities | 2023-08-21 | https://doi.org/10.1016/j.eclinm.2023.102148 | Jessica A. Breznik | https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00325-5/fulltext#%20 | Increased infection risk was associated with prior Omicron infection (at 9–29 days: 47.67 [23.73–95.76])... Counterintuitively, SARS-CoV-2 Omicron infection was associated with increased risk of Omicron reinfection in residents of long-term care and retirement homes. Less robust humoral hybrid immune responses in older adults may contribute to risk of Omicron reinfection. | |||||||||||||||||||||
17 | Superior neutralizing response after first versus second SARS-CoV-2 infection in fully vaccinated individuals | 2023-11-16 | https://doi.org/10.1002/jmv.29225 | Gonzalo Rivas | https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.29225 | SARS-CoV-2 specific neutralizing response after BA.1 infection was significantly higher in the BTI group (breakthrough infection) as compared with the REI (reinfection group). Furthermore, neutralization titers in REI were not significant different from convalescent non reinfected controls. Our results show that the first episode of SARS-CoV-2 infection induces a significant increase in neutralizing titers in triple vaccinated individuals and that previous SARS-CoV-2 infection compromise significantly the neutralization response induced by reinfection, even by divergent SARS-CoV-2 variants and at least up to 2 years postinfection. | |||||||||||||||||||||
18 | The burden of post-acute COVID-19 symptoms in a multinational network cohort analysis | 2023-11-17 | https://doi.org/10.1038/s41467-023-42726-0 | Kristin Kostka | https://www.nature.com/articles/s41467-023-42726-0.pdf | We report a consistent increase in the risk of persistent symptoms after reinfection compared to first infection. All post-acute COVID19 symptoms mentioned in the WHO clinical case definition appeared more common after reinfection than after a first infection, after matching by age, sex and date of infection. | |||||||||||||||||||||
19 | 3-year outcomes of discharged survivors of COVID-19 following the SARS-CoV-2 omicron (B.1.1.529) wave in 2022 in China: a longitudinal cohort study | 2023-11-21 | https://doi.org/10.1016/S2213-2600(23)00387-9 | Hui Zhang | https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00387-9/fulltext | During the omicron wave, participants with long COVID at 2 years had a significantly higher proportion of re-infection (76% vs 67% without long COVID). 3 months after omicron infection, (62%) of survivors with long COVID at 2 years had newly occurring or worse symptoms, which was significantly higher than the proportion in the non-long COVID group (41%] ) and community controls (40%). | |||||||||||||||||||||
20 | Experiences of Canadians with long-term symptoms following COVID-19 | 2023-12-08 | Sianne Kuang | https://www150.statcan.gc.ca/n1/pub/75-006-x/2023001/article/00015-eng.htm | Canadians reporting two known or suspected COVID-19 infections (25.4%) were 1.7 times more likely to report prolonged symptoms than those reporting only one known or suspected infection (14.6%), and those with 3 or more infections (37.9%) 2.6 times more likely. | ||||||||||||||||||||||
21 | Associations between Recurrent COVID-19, Attention, and Mental Health: A Longitudinal Study | 2024-01-18 | https://doi.org/10.21203/rs.3.rs-3670569/v3 | Mohammad Ahsan Khodami | https://www.researchsquare.com/article/rs-3670569/v3 | Overall, these results demonstrate significant worsening of depression, stress, and anxiety symptoms coupled with improvements in attentional control abilities over time for repeatedly COVID-19-diagnosed individuals. All DASS (Depression, Anxiety, and Stress Scale) subscales evidenced increases in mean scores from T1 to T2, reflecting worsening negative effects over time. | |||||||||||||||||||||
22 | Association of vaccine status, reinfections, and risk factors with Long COVID syndrome | 2024-02-02 | https://doi.org/10.1038/s41598-024-52925-4 | Maria Elena Romero-Ibarguengoitia | https://www.nature.com/articles/s41598-024-52925-4 | Long COVID-19 was more prevalent when subjects had reinfections (p = 0.02) and less frequent when they had a complete vaccination scheme (p = 0.05). This cross-sectional observational study showed a prevalence of Long COVID of 20.9% during the first infection, 14.8% during second reinfection and 16.7% after third reinfection. No distinction was observed between the vaccinated and unvaccinated groups during second and third reinfections. | |||||||||||||||||||||
23 | Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study | 2024-03-01 | https://doi.org/10.1016/j.eclinm.2024.102500 | Meijun Meng | https://www.sciencedirect.com/science/article/pii/S2589537024000798 | Compared with the contemporary control group, those infected with SARS-CoV-2 exhibited elevated risks for developing respiratory diseases. This includes asthma, with a HR of 1.49 and a 95% CI 1.28–1.74; bronchiectasis (1.30; 1.06–1.61); COPD (1.59; 1.41–1.81); ILD (1.81; 1.38–2.21); PVD (1.59; 1.39–1.82); and lung cancer (1.39; 1.13–1.71). Compared to those with one SARS-CoV-2 infection, reinfected patients were at a higher risk of asthma (3.0; 1.32–6.84), COPD (3.07; 1.42–6.65), ILD (3.61; 1.11–11.8), and lung cancer (3.20; 1.59–6.45). | |||||||||||||||||||||
24 | A prognostic model for SARS-CoV-2 breakthrough infection: Analyzing a prospective cellular immunity cohort | 2024-04-20 | https://doi.org/10.1016/j.intimp.2024.111829 | Mei Yang | https://www.sciencedirect.com/science/article/abs/pii/S1567576924003473 | SARS-CoV-2 breakthrough infection leads to disturbances in cellular immunity. After breakthrough infection with SARS-CoV-2, there was a decrease in effector T cells and an increase in naïve T cells. | |||||||||||||||||||||
25 | Post-Covid-19 condition (Long Covid) in children and young people 12 months after infection or reinfection with the Omicron variant: a prospective observational study | 2024-04-30 | https://doi.org/10.1038/s41598-024-60372-4 | Snehal M. Pinto Pereira | https://www.nature.com/articles/s41598-024-60372-4 | Overall, 22.6% of first-positives and 22.8% of reinfected CYP fulfilled our consensus Long Covid definition 3-months post-testing; by 12-months, this was 17.4% in first positives and 21.9% in reinfected CYP. 25 (7.2%) first-positive and 42 (11.7%) reinfected CYP meet the Long Covid definition at all time-points (i.e., 3-, 6- and 12-months post-infection). | |||||||||||||||||||||
26 | Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection | 2024-05-29 | https://doi.org/10.1038/s41392-024-01867-4 | Gang Yang | https://www.nature.com/articles/s41392-024-01867-4 | Serological confirmed reinfection rates differed significantly (P = 0.036) among the three groups with 53% of mild participants (6/13), 20% of moderate participants (4/20), and 15% of severe participants (3/19). Taken together, our data demonstrated that greater initial COVID-19 severity reduces the subsequent reinfection risk, and which may associate with the sustained maintenance of the virus-specific memory T cell responses. | |||||||||||||||||||||
27 | Unveiling Long COVID symptomatology, Co-occurrence trends, and Symptom Distress Post SARS-CoV-2 Infection | 2024-05-31 | https://doi.org/10.1016/j.jiph.2024.05.052 | Shikha Kukreti | https://www.sciencedirect.com/science/article/pii/S1876034124001990 | For individuals with infection counts of two or more times, there was a statistically significant increase in general symptoms (β=1.79, 95% CI: 0.51-3.02), cardiovascular symptoms (β=0.61, 95% CI: 0.09-1.13), and neuropsychological symptoms (β=2.18, 95% CI: 0.37-3.99). Additionally, the total distress score was notably higher in this group (β=6.35, 95% CI: 2.05-10.65). | |||||||||||||||||||||
28 | Presenting clinical symptoms of post-COVID-19 breakthrough infection: Predictors of mortality in a Middle Eastern population | 2024-06-01 | https://doi.org/10.1016/j.jvacx.2024.100495 | Asma S. Albtoosh | https://www.sciencedirect.com/science/article/pii/S2590136224000688 | Breakthrough COVID-19 infections are common following immunisation with various types of vaccines. This study indicates that despite more severe symptoms reported in younger patients, the major clinical outcomes were worse among older patients, which makes age a major risk for poor outcomes regardless of symptoms. Thus, older people should be evaluated carefully when presenting with mild symptoms of COVID-19 breakthrough infection. | |||||||||||||||||||||
29 | Post-COVID-19 illness among Quebec healthcare workers: frequency, evolution and risk factors | 2024-06-01 | Sara Carazo | https://www.inspq.qc.ca/publications/3510 | The cumulative risk of APC (post-COVID-19 illness) increases with the number of infections from 13% with one infection, to 23% with two infections and reaching 37% for three infections. A quarter of APC cases who had symptoms at the time of the survey had only mild symptoms, 42% had at least one moderate symptom without severe symptoms, and a third had at least one severe symptom. | ||||||||||||||||||||||
30 | Long-COVID symptom monitoring: Insights from a two-year telemedicine study | 2024-07-26 | https://doi.org/10.1371/journal.pone.0307834 | Andrea Foppiani | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0307834 | Out of 165 patients, 139 (84%) reported symptoms at the 1-year follow-up, while only 101 (61%) reported symptoms at the 2-year follow-up. Both having Long-COVID at the 1-year follow-up and contracting a second infection were significant risk factors for presenting with Long-COVID at the 2-year follow-up. | |||||||||||||||||||||
31 | PFC/M1 activation and excitability: a longitudinal cohort study on fatigue symptoms in healthcare workers post-COVID-19 | 2024-08-05 | https://doi.org/10.1186/s12967-024-05319-z | Tao Han | https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-05319-z | Our fNIRS and TMS results confirmed a renewed decrease in brain activation/excitability in patients re-infected with COVID-19 at 6 m, slightly higher than at 1 m but lower than at 3 m. This underscores the importance of vigilance regarding SARS-CoV-2 re-infection. | |||||||||||||||||||||
32 | Long-Term Morbidity and Mortality of COVID-19 in Patients Receiving Maintenance Dialysis: A Multi-Center Population-Based Cohort Study | 2024-08-16 | https://doi.org/10.34067/KID.0000000000000490 | Bota, Sarah E | https://journals.lww.com/kidney360/abstract/9900/long_term_morbidity_and_mortality_of_covid_19_in.413.aspx | When we accounted for reinfection in the model, we found that all of the risk factors from the previous model remained statistically significant and there was a 120% increased rate of long-term death for those who were reinfected (adjusted HR 2.2, 95% CI 1.4 to 3.3). Our findings suggest that reinfection may be an influential risk factor for death in the maintenance dialysis population. | |||||||||||||||||||||
33 | Specific persistent symptoms of COVID-19 and associations with reinfection: a community-based survey study in southern China | 2024-09-02 | https://doi.org/10.3389/fpubh.2024.1452233 | Dongjing Liu | https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1452233/full | Participants with reinfection were associated with a higher probability of reporting headaches (OR: 1.54, 95% CI: 1.06–2.25), loss of or change in smell and/or taste (OR: 1.90, 95% CI: 1.27–2.83), impaired sleep (OR: 1.55, 95% CI: 1.02–2.35), and brain fog (OR: 1.76, 95% CI: 1.12–2.76). | |||||||||||||||||||||
34 | Defining long COVID using a population-based SARS-CoV-2 survey in California | 2024-09-17 | https://doi.org/10.1016/j.vaccine.2024.126358 | Jake M. Pry | https://www.sciencedirect.com/science/article/pii/S0264410X24010405 | Participants reporting multiple COVID-19 infections have a significantly higher prevalence of long COVID with the highest prevalence of severe long COVID (PR: 1.84, 95 % CI: 1.21, 2.80) compared with people that reported only one COVID-19 infection. | |||||||||||||||||||||
35 | Long COVID and associated outcomes following COVID-19 reinfections: Insights from an International Patient-Led Survey | 2024-09-24 | https://doi.org/10.21203/rs.3.rs-4909082/v1 | Letícia Soares | https://www.researchsquare.com/article/rs-4909082/v1 | COVID-19 reinfections are associated with higher likelihood of Long COVID and related outcomes.Here we show that reinfections increase the likelihood of reporting Long COVID, which increased 2.1-fold from one to two infections (and 3.75x higher risk with 3 or more.) Relative to those who did not report infections or experienced COVID-19 once, reinfections were associated with increased likelihood of severe fatigue, post-exertional malaise, decreased physical function, poorer immune health, symptom exacerbation before menstruation, and multiple other Long COVID symptoms. | |||||||||||||||||||||
36 | Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants | 2024-09-27 | https://doi.org/10.1016/j.clim.2024.110371 | Liam Townsend | https://www.sciencedirect.com/science/article/abs/pii/S1521661624004807 | Frequent infections had similar IFNγ and IL-2 responses to the never infected group, with significantly higher responses in the asymptomatic group. An immune signature of blunted IL-2 and IFNγ in frequent infections may identify HCWs at increased risk of further infection. | |||||||||||||||||||||
37 | COVID-19 Disease Incidence and Severity in Previously Infected Unvaccinated Compared with Previously Uninfected Vaccinated Persons | 2024-10-08 | https://doi.org/10.1093/infdis/jiae484 | Adeel A Butt | https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiae484/7808431?login=false | The incidence of hospitalization/death is significantly higher after reinfection among unvaccinated individuals compared with breakthrough infection after vaccination. The incidence rate of hospitalization/death was higher after reinfection (7.31, 95% CI 6.66-8.03) compared with rate after breakthrough infection (4.69, 95% CI 4.06-5.42; P<0.0001). | |||||||||||||||||||||
38 | Long COVID facts and findings: a large-scale online survey in 74,075 Chinese participants | 2024-10-10 | https://doi.org/10.1016/j.lanwpc.2024.101218 | Shijie Qin | https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(24)00212-8/fulltext | Participants who experienced multiple infections were more likely to experience various long COVID symptoms with increased severity. Moreover, the multivariate regression analysis indicated that having two infections posed a significant risk for many long COVID symptoms, and the risk ratio increased exponentially when the number of infections exceeds two (OR > 2, FDR < 0.05). | |||||||||||||||||||||
39 | Risk of Reinfection and Incidence of Chronic Symptoms After SARS-CoV-2 Infections | 2024-10-15 | https://doi.org/10.1093/ofid/ofae608 | Liam Golding | https://academic.oup.com/ofid/article/11/10/ofae608/7822496?login=false | Chronic symptoms increased from a baseline of 21% (95% CI, 16%–28%) among infection-naïve individuals to 43% (95% CI, 30%–61%) in reinfected individuals. | |||||||||||||||||||||
40 | Long COVID Among Infected Students and Staff in Chiang Mai University, Chiang Mai, Thailand | 2024-11-09 | https://doi.org/10.1016/j.cegh.2024.101828 | Ekachai Jaiprom | https://www.sciencedirect.com/science/article/pii/S2213398424003257 | The results indicated that the prevalence of Long COVID was 51.9%. Among them 92.7% had multiple symptoms. The most common symptoms were fatigue (65.8%), easy tiredness (59.2%), and easy tiredness after physical activity (44.7%). Multiple logistic regression showed that factors associated with Long COVID were... those infected with Covid-19 twice or more compared to those infected once (aOR = 2.014, 95%CI = 1.346-3.012). | |||||||||||||||||||||
41 | Insights into the Risk Factors and Outcomes of Post-COVID-19 Syndrome—Results from a Retrospective, Cross-Sectional Study in Romania | 2024-11-20 | https://doi.org/10.3390/life14111519 | Ioana Bejan | https://www.mdpi.com/2075-1729/14/11/1519 | The risk of developing post-COVID-19 syndrome increased for those with more symptoms in the acute phase (OR 4.24, p < 0.001) and those experiencing reinfections (OR 2.405, p < 0.001), while SARS-CoV-2 vaccination halved the risk (OR = 0.489, p = 0.004). | |||||||||||||||||||||
42 | Post-recovery quality of life (QoL) of the healthcare professionals affected by COVID-19: a longitudinal study in Bangladesh | 2024-11-21 | https://doi.org/10.1186/s12982-024-00333-4 | Md. Utba Rashid | https://link.springer.com/article/10.1186/s12982-024-00333-4 | The participants who had a history of COVID-19 re-infection were 3.94 (AOR: 3.94, 95%CI 1.91, 8.16) and 2.81 (AOR: 2.81, 95%CI 1.37, 5.79) times more inclined to an inferior psychological and social QoL score, respectively in comparison to individuals who had not. | |||||||||||||||||||||
43 | A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people | 2024-12-04 | https://doi.org/10.1038/s43856-024-00657-x | Terence Stephenson | https://www.nature.com/articles/s43856-024-00657-x | 5+ symptoms were reported by 14·2% (643/4,534) of NN (Negative-Negative, ‘initial test-negatives with no subsequent positive test’) to 20.8% (108/519) of PP (Positive-Positive, ‘initial test-positives with a report of subsequent re-infection’) CYP (Children and Young People) (p < 0.001). We previously reported that 10% of NN, 16–20% of PNs and NPs, and 24% of PPs had 5+ symptoms 12 months post index-test; at 24 months corresponding values were 14% (NN), 17-18% (PN and NP) and 21% (PP). | |||||||||||||||||||||
44 | Refinement of post-COVID condition core symptoms, subtypes, determinants, and health impacts: a cohort study integrating real-world data and patient-reported outcomes | 2024-12-10 | https://doi.org/10.1016/j.ebiom.2024.105493 | Yunhe Wang | https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00529-2/fulltext | Participants with multiple infections (1.41 [1.33–1.50]) had a higher risk of any PCC compared to those with a single infection (1.10 [1.09–1.12]). Full vaccination and booster were associated with significantly lower risk of PCC compared to no or partial vaccination (no/partial 1.25 [1.20–1.29] vs booster 1.08 [1.06–1.10]). | |||||||||||||||||||||
45 | SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study | 2025-01-08 | https://doi.org/10.1016/j.lana.2024.100984 | Tesleem K. Babalola | https://www.sciencedirect.com/science/article/pii/S2667193X24003119 | We found a significant association between the risk of experiencing PASC and multiple SARS-COV-2 infections (RR = 1.41 [1.14–1.74]), severe COVID-19 (RR = 3.17 [2.41–4.16]), and being unvaccinated at first infection (RR = 3.29 [2.46–4.41]). | |||||||||||||||||||||
46 | Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong | 2025-01-20 | https://doi.org/10.1136/bmjph-2023-000833 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11816715/ | Vincent Ka Chun Yan | https://pubmed.ncbi.nlm.nih.gov/40017919/ | Among patients with COVID-19 infection requiring hospitalisation, COVID-19 re-infection was associated with increased post-acute mortality and morbidity compared with first-time infection.After a median follow-up of 170 days, re-infection was associated with a significantly higher risk of post-acute all-cause mortality compared with first-time infection (adjusted HR (95% CI): 1.366 (1.166 to 1.600)), all-cause hospital readmission (1.297 (1.200 to 1.403)), and attendance to emergency departments (1.307 (1.199 to 1.425)). | ||||||||||||||||||||
47 | Estimating risk of long COVID using a Bayesian network-based decision support tool | 2025-01-24 | https://doi.org/10.21203/rs.3.rs-5861767/v1 | Jane E. Sinclair | https://www.researchsquare.com/article/rs-5861767/v1 | Risk-benefit analysis showed that a higher number of pre-existing comorbidities and multiple SARS-CoV-2 infections were the factors most strongly associated with increased probability of long COVID at six months post-infection. A Bayesian network and online tool assessing long COVID risk were developed. They reflect incomplete vaccination, missed acute drug treatment, and repeated infections as key controllable risk-factors. | |||||||||||||||||||||
48 | Long COVID affects working memory: Assessment using a single rapid online test | 2025-01-28 | https://doi.org/10.1101/2025.01.26.25321152 | Aziz UR Asghar | https://www.medrxiv.org/content/10.1101/2025.01.26.25321152v1 | In our current investigation we found that objective memory scores decreased with increasing number of COVID-19 infections but only in the group diagnosed with long COVID. This finding supports the viewpoint that COVID-19 reinfections increase the severity of cognitive dysfunction in people with long COVID |
| A | B | C | D | |
|---|---|---|---|---|
1 | ||||
2 | CD4+, CD8+, CD19+ | Cluster of Differentiation Cells | CD4 cells lead the fight against infections. CD8 cells can kill cancer cells and other invaders. CD19 plays a large role in regulating B-cell growth, which are important to fight bacteria and viruses. | |
3 | CI | Confdience Intervals | A range of plausible values that accounts for uncertainty in a statistical estimate. For example, a study may find that a hazard ratio for a condition may be 1.96 (people with the condition have 1.96x the risk as the control group) but the actual number in the population isn't likely to be precisely that, so researchers provide a range at some level of confidence. For instance with a 95%CI, the data might show the real number could bein a rnage from 1.26 to 3.06. | |
4 | CTLs | Cytotoxic T lymphocytes | One of several types of cells of the immune system that have the capacity to directly kill other cells. They play a major role in host defense against viral infection. | |
5 | CVD | Cardiovascular Disease | A term for a group of disorders that affect the heart and blood vessels | |
6 | DCs | Dendritic Cells | A special type of immune cell that is found in tissues, such as the skin, and boosts immune responses by showing antigens on its surface to other cells of the immune system. They are responsible for the initiation of adaptive immune responses and hence function as the ‘sentinels’ of the immune system. | |
7 | Excess burden | The number of additional instances of disease or outcomes per 1,000 people that is found from one group studied compared to a healthy control group. For example, "13·46, 95% CI 12·11–14·84, per 1000 people at 12 months" would mean 1,000 people with same attributes as the tested group would have 13.46 more instances per 1,000, with the 95% confidence range being between 12.11 and 14.84. | ||
8 | HR | Hazard Ratio | A measure of how often a particular event happens in one group compared to how often it happens in another group. In studies, this represents the risks of one group (who have a condition or received a treatment) compared to the risks to a control group. | |
9 | HRQoL | Health-Related Quality of Life | A multidimensional assessment of how a person's health impacts their overall well-being and ability to live a fulfilling life | |
10 | Humoral Responses | One of the two primary mechamisms of immunity. Humoral response is antibody-mediated immunity (as opposed to cellular immunity). With assistance from helper T cells, B cells will differentiate into plasma B cells that can produce antibodies against a specific antigen. | ||
11 | Immune imprinting | A phenomenon in which an initial exposure to a virus — such as the original strain of covid, by infection or vaccination — limits a person’s future immune response against variants. | ||
12 | immunosenescence | Changes in the immune system associated with age. | ||
13 | IR, IRR | incident rate, incidence rate ratios | Incidence rate is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time. Incident Rate Ratio is the relative incidence rate between two groups--generally a group with a condition versus a healthy control group. | |
14 | Lymphocytes | Lymphocytes are a type of white blood cell. They help your body’s immune system fight cancer and foreign viruses and bacteria. | ||
15 | LC | Long COVID | See PASC. | |
16 | MACE | major adverse cardiovascular events | ||
17 | Macrophage | A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells. | ||
18 | ME/CFS | Myalgic encephalomyelitis/chronic fatigue syndrome | A serious, chronic, complex, and systemic disease associated with neurological, immunological, autonomic, and energy metabolism dysfunction | |
19 | MIS-C | Multisystem inflammatory syndrome in children | Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious hyperinflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that typically occurs several weeks after acute infection. | |
20 | Monocytes | Monocytes are a type of white blood cell (leukocytes) that reside in your blood and tissues to find and destroy germs (viruses, bacteria, fungi and protozoa) and eliminate infected cells. Monocytes call on other white blood cells to help treat injury and prevent infection. | ||
21 | myeloid cells | A type of blood cell that originates in the bone marrow. Myeloid cell mature into the adult blood cells bodies need for health, including basophils, eosinophils, erythrocytes, macrophages, monocytes, neutrophils, or platelets. | ||
22 | NAb | neutralizing antibody | An antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically. Neutralization renders the particle no longer infectious or pathogenic. | |
23 | PACS | post-acute COVID-19 syndrome | Long COVID | |
24 | PASC | post-acute sequelae of COVID-19 | Medical term for Lond COVID. Symptoms that persist for months after acute recovery and can involve many organs and systems. Symptoms include fatigue, shortness of breath, “brain fog,” sleep problems, fever, anxiety, and depression. | |
25 | PCC | Post-COVID Condition | Another term for Long COVID. | |
26 | PCS | Post-COVID Syndrome | Another term for Long COVID. | |
27 | POTS | postural orthostatic tachycardia syndrome | A condition where a person experiences a rapid increase in heart rate when standing up from a sitting or lying position, often causing dizziness, lightheadedness, or fainting due to a drop in blood pressure | |
28 | RBD | Receptor-Binding Domain | A key part of a virus located on its ‘spike’ domain that allows the virus to dock to body receptors, entry into cells, and cause infections. | |
29 | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 is the virus responsible for the disease COVID-19. People who get COVID are infected with the SARS-CoV-2 virus. | |
30 | Thrombogenicity | The tendency of a material in contact with the blood to produce a thrombus, or clot. It not only refers to fixed thrombi but also to emboli, thrombi which have become detached and travel through the bloodstream. | ||
31 | T-cells | A type of white blood cell that attacks specific antigens to defeat infections. Part of the adapative immune systems, T-cells are created following an infection to prevent infection from the same pathogen. |
| A | B | |
|---|---|---|
1 | Number of studies included in each tab: | |
2 | How to Use This Spreadsheet | |
3 | Cardiovascular | 239 |
4 | Cancer | 39 |
5 | Immune System | 134 |
6 | Neuro/Brain | 413 |
7 | Other | 108 |
8 | Pregnancy/Reproduction | 46 |
9 | Reinfections | 798 |
10 | Glossary | |
11 | Data | |
12 | ||
13 | ||
14 | TOTAL | 1,777 |