Progress of Crowdfight requests


1	Progress				Crowdfight requests
7	Feedback from the community collected
8		Advisor assigned, and shortlisting most suitable experts
9			Advisor report ready: Shortlist of experts ready
10				Proposal sent: Final experts selected, and put in contact with the requester
11
12	TRUE	TRUE	TRUE	TRUE	Task 1150[a] Crowdfight is looking for developers to help improve our web interface using the no-code tool Adalo. Experience with this tool (or other no-code tools) is preferred, but anyone with basic programming skills (in any language) can learn to use Adalo in a few hours. Other useful skills: Web design, web development, UX, relational databases, REST API.
13	TRUE	TRUE	TRUE	TRUE	Task 1159[a] A private company is looking for a French or English speaking expert in the naval (shipyard) operations maintenance field to provide insights on the functionalities of naval maintenance, particularly in the ship refit domain, such as constraints of this domain, typical maintenance procedures, various tasks and durations etc. If the expert has access to real ship maintenance data and could share them, this would be even better.
14	TRUE	TRUE	TRUE	TRUE	Task 1141[a] A group has AlphaFold in silico evidence that a specific mannose-binding lectin (MBL) may be a plausible candidate for inhibiting SARS-CoV-2 by leveraging the innate immune system (vs. the slower adaptive one via vaccines). It may prove to be a good low cost, stable (i.e. no cold storage), easily accessible, and fast-acting alternative (see summary here: deck). They are looking for biology/biomedical researchers (e.g. virologists, clinical technicians) interested in collaborating by performing in vitro and/or in vivo experiments based on their evidence.
15	TRUE	TRUE	TRUE	TRUE	Task 1140[a] A clinical psychologist who conducts research on mental health and resilience in different regions around the world, most recently in relation to the Covid-19 pandemic (see background and RE-COVER project), would like to initiate a similar research project directed at the effects of the Ukraine crisis in different world regions (excluding, for now, Ukraine and Russia). For example, they are interested in studying how PTSD symptoms vary in response to how media reports on the crisis in Ukraine and whether the region is close to Ukraine or not, among other possible relationships. They are looking for long-term collaborators interested in similar lines of research (e.g. PTSD, war, media, mental health) to join this new project, and are particularly keen to hear from those who can collect and analyse data from surveys (the main data collection method).
16	TRUE	TRUE	TRUE	TRUE	Task 1120[a] A pair of researchers at a private research lab have produced a manuscript describing a broad antiviral candidate specificity mechanism for a well-studied class of natural compounds. They are looking for someone who can make a 2D black-and-white chemical structure graphic of several flavonoid glucuronides. They need to know that the graphics produced are freely licensable for journal submission/publication. They will provide appropriate acknowledgement to the individual(s) who helps with these figures.
17	TRUE	TRUE	TRUE	TRUE	Task 1115[a] A researcher in London (UK) is looking for a cell line with confirmed expression of human ACE2 to serve as a positive experimental control for immunocytochemistry staining. Ideally, they would like to find someone with a cell line in the greater London area so they can collect them.
18	TRUE	TRUE	TRUE	TRUE	Task 1110[a] A researcher is looking for a database (or other resources) that provides information about the number of Covid-19 cases and related deaths in the city of Porto, Portugal, preferably one that includes a breakdown of the number of cases by ‘freguesia’.
19	TRUE	TRUE	TRUE	TRUE	Task 1104[a] A researcher is looking for an anatomopathologist who can help identify the nature of tumors in a mutant line of zebrafish. They want to confirm if the tumors are liposarcomas.
20	TRUE	TRUE	TRUE	TRUE	Task 1102[a] A researcher is looking for an expert in data analysis capable of extracting behavioural patterns from 3D tracking and videos of foraging bumblebees.
21	TRUE	TRUE	TRUE	TRUE	Task 1094[a] A researcher is looking for people who could solve co-structures between drugs and Spike protein and ACE protein. The drugs selected by their team have been shown to efficiently block SARS-CoV-2 entry for the original strain and circulating variants. Co-crystals between drugs/S and drugs/Ace2 should be easy to get by soaking and X-ray diffraction. CryoEM may also be possible. The drugs are currently under patent and the corresponding MS is under preparation. Data would be included in this MS or in a follow up one depending on the timing (the main aim is to get these drugs available for further animal model and clinical trials).
22	TRUE	TRUE	TRUE	TRUE	Task 1091[a] A researcher needs help to analyze experimental data from stop-signal reaction times in humans. He needs advice on sound statistical methods to detect outliers in the dataset (these can be general statistical methods), and also more specialized advice on methods to estimate the stop-signal reaction times (SSRTs).
23	TRUE	TRUE	TRUE	TRUE	Task 1090[a] A researcher is looking for advice and/or antibodies used in co-immunoprecipitation of endogenous Smad7 (inhibitory Smad in the TGF-beta signaling pathway). Many publications in which endogenous Smad7 co-IP is done use antibodies produced in-house. They would like some advice on why endogenous Smad7 cannot be pulled down with commercial antibodies, and especially if there are people willing to share antibodies they have had success with. They would also like a discussion regarding immunoblotting of Smad proteins in general (Smads 2/3/4), especially in T cells, e.g. stimulation conditions, cell numbers, lysis conditions etc.
24	TRUE	TRUE	TRUE	TRUE	Task 1087[a] A researcher is looking for a specific E. coli strain rom ATCC: E. coli (Migula) Castellani and Chalmers (ATCC® 35860-). Unfortunately, it is no longer available from the ATCC strain catalogue and they are wondering if someone would still have a stock and be willing to ship it (costs covered of course).
25	TRUE	TRUE	TRUE	TRUE	Task 1086[a] A researcher is looking for a collaborator with access to a BSL-3 lab to perform experiments with the live SARS-CoV-2 virus. They have obtained data from a simplified model of SARS-CoV-2 infection, suggesting that membrane trafficking of the SARS-CoV-2 spike protein can be modulated by a low concentration of the antidepressant Fluvoxamine, suggesting a cell biological mechanism underlying potential utility of antidepressants in COVID-19 therapeutics: (https://www.biorxiv.org/content/10.1101/2021.06.15.448391). They would like to confirm this finding with the live SARS-CoV-2 in a physiologically relevant system (primary cells, organoids, model organisms, etc...)
26	TRUE	TRUE	TRUE	TRUE	Task 1084[a] A researcher is looking for someone with research interest / background in biomolecular condensates (or liquid liquid phase separation) and/or virology, to write a review article together with a highly collaborative & international research team led by himself. The project will be focused on SARS-CoV-2, but other viruses will also be included.
27	TRUE	TRUE	TRUE	TRUE	Task 1083[a] A researcher in France would like to discuss with experts in the history and evolution of handwriting. In particular, they would like to know what methods exist to study how the shape of handwritten symbols change over time and across space.
28	TRUE	TRUE	TRUE	TRUE	Task 1082[a] A private company in New Zealand working on specific drug targets to be repurposed for Covid-19 is looking for collaborators who can perform certain biochemical, cellular and protein interaction assays. Specifically, they are interested in building collaborations with those who have expertise in the following:
29	TRUE	TRUE	TRUE	TRUE	Task 1081[a] A researcher in Greece is looking for a long-term collaborator with experience in metabolomics. They are starting a project on metabolic characterization and amino-acid concentrations in a series of samples related to fish gut microbiomes.
30	TRUE	TRUE	TRUE	TRUE	Task 1072[a] A researcher is looking for a protocol of Ral GTPase activity assay. They are considering buying one activity kit (for example https://www.cytoskeleton.com/bk040) and are looking for personal experience.
31	TRUE	TRUE	TRUE	TRUE	Task 1069[a] A private company in New Zeland is working on specific drug targets to be repurposed for Covid-19. They are looking for a bio-containment facility for SARS-CoV-2 propagation and conducting CPE and plaque reduction assays.
32	TRUE	TRUE	TRUE	TRUE	Task 1066[a] A non-profit organisation devoted to spreading real scientific content (https://stemcognito.org/) is looking for coronavirus and vaccine experts. They want to collect videos that could include simply slides, interviews, panel discussions or animated videos, to highlight the safety and efficacy of COVID-19 vaccines. They can also help in the production of new videos (free of costs). They are also hoping for experts that would be interested in participating in a panel discussion on vaccine safety that they would record and make available.
33	TRUE	TRUE	TRUE	TRUE	Task 1059[a] A researcher is studying how users of self-quantifying technology (related to nutrition in particular) are affected by stressful living conditions and times of uncertainty. They are focused on a particular demographic (Dutch millennials who use nutrition tracking apps) and would like to discuss about their research with other researchers that work on similar projects.
34	TRUE	TRUE	TRUE	TRUE	Task 1060[a] A researcher in Europe is looking for THP-1 (human acute monocytic leukemia) cell line. They are interested in differentiating the cells into M1 and/or M2 macrophages for use in in vitro culture.
35	TRUE	TRUE	TRUE	TRUE	Intro to request 1051: A research group is attempting to set up Oxford nanopore NGS for analysis of whole SARS-COV2 genomes. They are currently trying to use an ARTIC V3 amplicon tiling protocol.
36	TRUE	TRUE	TRUE	TRUE	Task 1051[a] They would like to discuss with someone that has experience in any of the following:
37	TRUE	TRUE	TRUE	TRUE	Task 1051[b] They have limited capabilities in terms of computing power and experience in bioinformatics. They would like some help to being able to use remote computers or some guidance around bioinformatics.
38	TRUE	TRUE	TRUE	TRUE	Task 1056[a] Serratus is an Open Science project to capture the planetary virome. The goal is to allow the entire virology community to quickly and intuitively access the relevant virus sequence data across all of Earth's virome. They would like to expand the technical and non-technical interfaces for their data structures (see: serratus.io). They are looking for experienced developers working in: javascript, react, d3, postgres, and/or R.
39	TRUE	TRUE	TRUE	TRUE	Task 1055[a] A non-profit enterprise is builing an open-source web-based platform aimed at the dissemination of artificial intelligence / machine-learning (AI/ML) models for drug discovery. They are looking for a full-stack developer who can contribute to their GitHub repository.
40	TRUE	TRUE	TRUE	TRUE	Task 1049[a] A researcher is looking for collaborators with expertise on behavioral change based on social cognition. They want to start a project focused on changing human behavior towards actions that emit less carbon (eg eating less beef, bicycling more, etc.).
41	TRUE	TRUE	TRUE	TRUE	Task 1050[a] A researcher is looking for advice on an optimized protocol for protein isolation. They bought an Elisa kit to measure p-GSK3beta. But they can't find any information in the manual if this kit can be used for samples from tissue homogenate. They would like to have a brief discussion with an expert that could give them some advice.
42	TRUE	TRUE	TRUE	TRUE	Task 1028[a] The team from the COVID19PATGENOME (https://devpost.com/software/covid19patgenome) are looking for expression data from COVID-19 patients. They are looking for bulk RNA-seq data (Raw data counts - normalized values/ counts; not single cell RNA-seq) from blood or another tissue/organ including lung (ephitelium,etc.), or multiple organs (for example: lung+bowel+other organs in case of autopsies). They are interested in cohorts or projects with at least 60 patients or more and healthy controls. Preference for severe cases or diseased.
43	TRUE	TRUE	TRUE	TRUE	Task 1042[a] A researcher is looking for advices and tips on how to perform immunofluorescence imaging of haematopoietic stem/progenitor cells in mouse foetal liver. They didn’t find specific information in the literature so they are looking to discuss with an expert about a specific location in the foetal liver where HSPCs are to be found and optimisation of the staining procedure.
44	TRUE	TRUE	TRUE	TRUE	Intro to request 1040: A research group is starting a project producing growth factors and cytokines in bacteria.
45	TRUE	TRUE	TRUE	TRUE	Task 1040[a] They would like to contact groups and professionals that are experienced in transforming bacteria with plasmid for GF or
46	TRUE	TRUE	TRUE	TRUE	Task 1040[b] They would like to get a plasmid sample for this kind of molecule to run some tests.
47	TRUE	TRUE	TRUE	TRUE	Task 1034[a] A researcher in France is looking for Venezuelan Equine Encephalitis Virus-positive sera (IgG and IgM, 100µl to 1ml per sample). They will pay shipping costs.
48	TRUE	TRUE	TRUE	TRUE	Task 1031[a] A researcher in Ghana is looking for collaborators to study the pathology and immunology of COVID19 in pregnancy among Ghanaian women. They would like to write a grant to perform their study. They are looking for a senior researcher who can advise on project design and strengthen the proposal or for someone that has already a similar project. If that's the case, they can facilitate the collection of samples from Ghana to achieve a cross country comparison study.
49	TRUE	TRUE	TRUE	TRUE	Task 1030[a] A researcher in Australia is looking to collaborate with epidemiologists/researchers looking at the effects of long-term lockdown and online learning on school age children. The aim is to gain information on eye health, specifically refractive error/myopia, to correlate this with outdoor activity. They want to investigate whether long-term lockdown contributes to an increase in the prevalence of early-onset myopia They would like to collaborate with: Epidemiologists, vision scientists, ophthalmologists, neuroscientists, molecular biologists and/or geneticists.
50	TRUE	TRUE	TRUE	TRUE	Intro to request 1029: A recently formed Ethnicity and Covid-19 research consortium is looking for volunteers with experience conducting systematic reviews to help with two separate living systematic reviews related to Covid-19 research involving Black, Asian and Minority Ethnic (people of colour) populations. Co-authorship from all publications will be granted to all volunteers involved in these projects.
51	TRUE	TRUE	TRUE	TRUE	Task 1029[a] They are looking for volunteers with a background in creating search strings, performing searches and screening via abstrackr (both abstracts and full text papers), PRISMA reporting and using reference management software to extract data.
52	TRUE	TRUE	TRUE	TRUE	Task 1029[b] They are looking for volunteers to assist with appraisal and assessing for risk of bias for full text papers that will be included in the systematic review
53	TRUE	TRUE	TRUE	TRUE	Task 1029[c] They are looking for volunteers to assist with the analysis, synthesis and interpretation of both qualitative and quantitative data included for the systematic review
54	TRUE	TRUE	TRUE	TRUE	Task 1029[d] They are looking for volunteers with experience in writing research articles to assist specifically with publication of papers arising from the systematic review.
55	TRUE	TRUE	TRUE	TRUE	Task 1029[e] They are looking for volunteers to join a team to contribute to the development of a Covid-19 database that has been initiated: (i) to assist with content and (ii) to work on the design (UI designer or a Front end developer with an eye for design).
56	TRUE	TRUE	TRUE	TRUE	Task 1022: We are hoping to find a research group that would be willing to share a SARS-CoV-2 (or related coronavirus) replicon/ non-infectious reporter virus (that can be used in BSL-2)
57	TRUE	TRUE	TRUE	TRUE	Intro to request 986: A biotech company is looking for volunteers to assist with a project that aims to identify and isolate anti-SARS-CoV-2 bioactive substance from natural sources such as medicinal herbs, traditional medicine, and functional food.
58	TRUE	TRUE	TRUE	TRUE	Task 986[a] They are seeking help from a volunteer to perform a literature search. The aim of this literature search is to narrow down the number of targets for testing. They may suggest some particular kinds of natural sources or take on the recommendations of the collaborator.
59	TRUE	TRUE	TRUE	TRUE	Task 986[b] They have a few purified samples/fractions derived from functional food sources which they would like to test for antiviral activity. Therefore, they are looking for collaborators/volunteers who have the capacity to perform some biochemical/enzymatic assays, or even use live/attenuated virus or pseudovirus models to check for anti-COVID activity.
60	TRUE	TRUE	TRUE	TRUE	Task 986[c] They are looking for volunteers who would like to be involved in collaborative writing, on topics including plants/food/herbs with potential anti-COVID/anti-SARS-CoV-2 ability. They are happy to contribute to review articles, or research articles should there be any collaborative research work established.
61	TRUE	TRUE	TRUE	TRUE	Intro to request 983: An interdisciplinary team at Boston College and the University of Maryland at College Park are studying how child development is being affected by pandemic-related disruptions.
62	TRUE	TRUE	TRUE	TRUE	Task 983[a] They need Web/app developers to extend the functionality of their "citizen science" app, which volunteers use to record speech samples of their children. They are using Firestore for database storage, Capacitor to package the app in iOS/Android, and React and Web Components to structure the app.
63	TRUE	TRUE	TRUE	FALSE	Task 983[b] They have been working with a streaming aggregator (Reelgood) to collect ground-truth data about changes in child screen time. They would love to hear form anybody who has access (or may possibly have access) to similar data from other companies: streaming companies, television ratings companies, child-focused app companies, etc.
64	TRUE	TRUE	TRUE	TRUE	Task 985[a] A researcher in Finland is looking for a collaborator who can perform SARS-CoV2 replication assays in vitro (plaque forming assay or similar / biosafety S3 level facilities needed). Virus samples will be provided.
65	TRUE	TRUE	TRUE	TRUE	Intro to request 973: A recently formed Ethnicity and Covid-19 research consortium is currently conducting a systematic review and mixed methods study examining the experiences of ethnic minorities across developed countries.
66	TRUE	TRUE	TRUE	TRUE	Task 973[a] They are seeking help from a volunteer to assist in further developing a database for a pilot project lasting 3 months (They estimate it would involve ~2hr/day for 2 weeks, then up to 2hr/week). The volunteer will work with others with similar backgrounds and should have hands-on experience with:
67	TRUE	TRUE	TRUE	TRUE	Task 973[b] They are seeking two volunteers who can offer 2-3 hours per week to assist with office tasks, scheduling and booking Zoom appointments, and email follow-up. The volunteer should be computer literate and, ideally, have a good understanding of Zoom and other basic web application software, such as Trello.
68	TRUE	TRUE	TRUE	TRUE	Task 973[c] They are requesting volunteers, ideally with a background in policy-making or healthcare, that reside in different states in the USA to help gather information for a database about Covid-19 testing centers and regional testing and health information about Covid-19. Volunteers, please indicate your state in the response form.
69	TRUE	TRUE	TRUE	TRUE	Task 973[d] They are seeking a collaborator at the University of Adelaide with a background in public health and/or sociology to assist with the recruitment of participants in Australia for their mixed methods study focusing on the experiences of ethnic minorities during the Covid-19 pandemic.
70	TRUE	TRUE	FALSE	FALSE	Task 969[a] We are looking for information about biobanks. We often receive requests asking for biological samples so we would like to expand our list of biobanks that could help our requesters. If you have useful information please write it below.
71	TRUE	TRUE	TRUE	FALSE	Task 937[a] A school management team needs a literature search for studies that show covid positivity rates stratified by age (specially for children)
72	TRUE	TRUE	TRUE	TRUE	Task 918[a] A researcher in London (UK) is looking for A549 cells stably transfected with human ACE2
73	TRUE	TRUE	TRUE	TRUE	Task 784[b] A research group is looking for some open genomic data (FASTQ files) from patients. Ideally, they would like to have the genomic data + clinical data. They are working on a project based on genomic data from COVID-19 patients (https://devpost.com/software/covid19patgenome).
74	TRUE	TRUE	TRUE	TRUE	Task 912[a] A researcher based in King's College London is looking for lab in Europe that can host him for a short-term academic visit (several weeks) to expand an ongoing research project on anti-COVID-19 drug development and repurposing. Resources required: BSL1/2 cell culture; lab space for 1 person; ELISA setup. Desirable: ongoing culture of human lung cell lines; confocal microscopy capabilities; potential for further validation in primary human cells and/or animal models and/or live SARS-CoV-2 virus (BSL3). Further details concerning the project can be found in this publication: https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15369
75	TRUE	TRUE	TRUE	TRUE	Task 903[a] A research group is looking for two sociologists/psychologists from Aboriginal and Torres Strait Islanders backgrounds to join their team. They are a recently formed Ethnicity and Covid-19 international research consortium currently conducting Covid-19 research throughout developed countries. The aim is to help them recruit participants from these minority ethnic groups for a mixed methods study, (survey and qualitative interviews).
76	TRUE	TRUE	TRUE	TRUE	Intro to request 902: A recently formed Ethnicity and Covid-19 research consortium is currently conducting a systematic review and mixed methods study examining the experiences of ethnic minorities across developed countries.
77	TRUE	TRUE	TRUE	TRUE	Task 902[a] They are seeking help from two app developers and two web designers to create a mobile phone software application for both iPhone and Android devices and a web-based platform based.
78	TRUE	TRUE	TRUE	TRUE	Task 902[b] They are seeking researchers with the ability to read and understand Spanish language to help us analyse data (research articles and grey literature) for a systematic review.
79	TRUE	TRUE	TRUE	TRUE	Task 902[c] They are seeking three professionals with experience and background in mental health who are enthusiastic towards helping set up an online support group with various activities to promote positivity and coping skills in the midst of the pandemic.
80	TRUE	TRUE	TRUE	TRUE	Task 902[d] They are seeking professionals with experience in medical writing, journalism, writing publications, peer reviewing and editing to help with research outputs based on research data.
81	TRUE	TRUE	TRUE	TRUE	Task 902[e] They are looking for two persons with a background in health or medicine that are willing to appear in short videos inviting people to take part in the study. The volunteers must be from a developed country and from an ethnic minority as follows:
82	TRUE	TRUE	TRUE	TRUE	Intro to request 899: A research group is looking for study to validate a very simple serological test.
83	TRUE	TRUE	TRUE	TRUE	Task 899[a] They are looking for a study that would already be in place to perform serological tests as well as collect whole blood samples. This could either capillary blood collected by pricking finger tips, or whole tubes of blood collected on anti-coagulant. They would join this study, performing their test on the collected samples.
84	TRUE	TRUE	TRUE	TRUE	Task 899[b] Alternatively, they are looking for collaborators who can set-up up a clinical trial to validate this serological test very fast, including meeting all ethical requirements (in France and in normal conditions this takes many months, and they need a faster pace)
85	TRUE	TRUE	TRUE	TRUE	Task 893[a] An independent and multidisciplinary team of volunteers is looking for a social media/PR manager. They are working on gathering workplace data on incidence and prevalence of COVID-19.
86	TRUE	TRUE	TRUE	TRUE	Intro to request 896: A PRIVATE COMPANY is looking for help to meet the requirements for a medical device. They have developed an RNA extraction kit for Covid 19 that has been tested in multiples labs.
87	TRUE	TRUE	TRUE	TRUE	Task 896[a] They are looking for detailed guidelines on the manufacturing specifications for Viral RNA extraction kit for SARS-CoV-2 (i.e. required clean room environment, batch conformity testing, and sterility confirmation testing).
88	TRUE	TRUE	TRUE	TRUE	Task 896[b] They need help with the certification and licensing requirements for an RNA extraction kit.
89	TRUE	TRUE	TRUE	TRUE	Task 879[a] A research group is looking for collaborators to test a drug in vivo. They found a drug combo that is very effective in suppressing SARS-COV-2 replication in vitro and would like to seek collaboration with in vivo efficacy validation.
90	TRUE	TRUE	TRUE	TRUE	Task 872[a] A researcher needs to discuss with other researchers using the Zymo kit or ideally the Zymo kit combined with the Genesig kit. They are having some issues with RNA loss and would like to have some advice. They are using the Zymo Quick DNA/RNA mag bead kit (R2141) and the Genesig Prime Design qPCR kit (Z-Path-COVID-19-CE).
91	TRUE	TRUE	TRUE	TRUE	Task 870[a] A researcher is looking for several collaborators that are representatives or have access to populations of Native Americans (in the USA and Canada) and Aborigines in Australia. The aim is to gather their experiences of COVID-19 through an online survey and, if possible, to conduct remote interviews.
92	TRUE	TRUE	TRUE	TRUE	Task 862[a] A nonprofit in the UK needs help translating 2 documents from English into: Spanish, Portuguese, Italian and German. The volume of work is a total of 1,100 words of English with some scientific and medical vocabulary. Their aim is to connect researchers in biotech and pharma with biospecimen providers. These documents are required to recruit more biobanks to join their platform.
93	TRUE	TRUE	TRUE	TRUE	Task 849[a] A cell biologist is looking for another cell biologist or a virologist to discuss a manuscript he has written. He has performed a deep review of the coronavirus literature to see if there was something useful as perhaps a potential anti-viral strategy.
94	TRUE	TRUE	TRUE	TRUE	Task 851[a] A researcher would like to discuss with an expert with a background in validating diagnostic protocols. They need assistance on validating an extraction and qPCR protocol.
95	TRUE	TRUE	TRUE	TRUE	Task 846[a] A research group in Chile is looking for a collaborator with access to serum/BALF of COVID-19 patients and transformed mink lung epithelial cell line (TMLC). If not possible, they would still be interested in receiving the TMLC.
96	TRUE	TRUE	TRUE	TRUE	Task 839[a] A research group in Spain is looking for a collaborator with access to blood samples of COVID-19 patients. Ideally, they would like someone who can perform ELISA for one protein (a stress marker) and send them the results, but they can also receive the samples and perform the ELISA themselves.
97	TRUE	TRUE	TRUE	TRUE	Task 698[a]: A research group (health experts and a statistician) is coordinating a grassroots effort to collect data on patients with Covid-19. They seek contacts in additional hospitals to collect detailed history of disease progression and treatment of hospitalized Covid-19 patients. The main focus is on efficacy of experimental pharmacological treatments and on biomarkers of disease progression. They work with detailed data, but are happy with small patient cohorts (5 or more per site). The resulting dataset will be accessible to other researchers. The project has been approved by an ethical commission.
98	TRUE	TRUE	TRUE	TRUE	Intro to request 808: A researcher is looking for time-series data describing how the number of people who wear masks, or who self-distance relates to simple factors such as age, gender, socio-professional group or previous experience of pandemics, or more complex ones like social norms or approval of others. Her aim is to model these data within a more dynamical framework (individual based models) to understand how introducing a continuous variability in these factors may affect results.
99	TRUE	TRUE	TRUE	TRUE	Task 808[a]: If you are aware of any literature please write below.
100	TRUE	TRUE	TRUE	TRUE	Task 808[b]: If these data do not exist, please state if you (or someone you may know) are interested in collaborating with this researcher to investigate how to gather these data.
101	TRUE	TRUE	TRUE	TRUE	Task 809[a]: A researcher in Stellenbosch, South Africa, is looking for someone to help set up an antibody ELISA. All capable virology people in their lab are working flat-out in the diagnostic laboratory or translational research projects so the need more hands to assist. They are willing to pay for accommodation but the person should already be in South Africa (preferably from the Western Cape province) and available for ~2 weeks.
102	TRUE	TRUE	TRUE	TRUE	Task 818[a]: A researcher in the USA is looking for BSL2-compatible GFP-tagged human coronavirus (hCoV) strains. It would be ideal to have a BSL2-compatible version of SARS-CoV-2. If that proves to be too difficult, then BSL2-compatible, GFP-tagged strains for hCoV-NL63 and hCoV-OC43 would be great.
103	TRUE	TRUE	TRUE	TRUE	Task 818[b]: They are also looking for a database with numeric values for intracellular rates of transcription, translation, molecular binding association & dissociation, viral assembly steps, as well as copy numbers for as many viral components as possible.
104	TRUE	TRUE	TRUE	TRUE	Task 803[a]: We at Crowdfight need advice on anti-spam filters and domain reputation. We are having some trouble with our e-mails being blocked by anti-spam filters and our domain being flagged as suspicious. We are looking for someone with expertise in these fields, or someone with expertise in IT and willing to do some research into the matter.
105	TRUE	TRUE	TRUE	TRUE	Task 784[a]: A research group is looking for some open genomic data (FASTQ files) from patients. Ideally, they would like to have the genomic data + clinical data. They are working on a project based on genomic data from COVID-19 patients (https://devpost.com/software/covid19patgenome).
106	TRUE	TRUE	TRUE	TRUE	Task 793[a]: Are you willing to contribute regularly to an anonymous survey to monitor the evolution of the COVID-19 pandemic in your region? The survey takes less than 2 minutes to fill (https://coronasurveys.org/), and filling it once or twice a week is enough.
107	TRUE	TRUE	TRUE	TRUE	Task 798[a]: A research group is looking for Dicom files of CT scans and/or angiograms from Covid-infected patients. They are investigating the effect of the disease on coronary arteries.
108	TRUE	TRUE	TRUE	TRUE	Intro to request 800: A PRIVATE COMPANY has strong knowledge on lentiviral vector design, which is a suitable platform to rapidly screen a wide range of factors in vitro and in vivo, including antigens for vaccination. They would like to characterize and compare candidate antigens through this technique. They are looking for:
109	TRUE	TRUE	TRUE	TRUE	Task 800[a]: Partners who can provide sequences of covid-19 potential antigens (preferably in the form of plasmids, but they could also synthesize them from a computer file with the sequence).
110	TRUE	TRUE	TRUE	TRUE	Task 800[b]: Partners who have in vitro and in vivo vaccine models to test LV carrying antigen.
111	TRUE	TRUE	TRUE	TRUE	Task 776[a]: A researcher is looking for SARS-CoV-2 gene expression data using microarrays. He is studying genetic differences across time and space, so he needs the data annotated by date and place of origin, and needs at least 4-5 samples per region and period.
112	TRUE	TRUE	TRUE	TRUE	Task 792[a]: A research group is looking for assistance from systems biologists and proteomics experts to assist with data analysis. They have predicted which human proteins may be cleaved by the SARS-CoV-2 main protease. They need this assistance in order to understand the relevance to host-viral interactions and disease pathogenesis.
113	TRUE	TRUE	TRUE	TRUE	Task 785[a]: A research group in Australia is looking for a collaboration to perform antiviral assays (cell culture). They have identified lead compounds that may inhibit viral replication. They need the antiviral assays to validate their molecular modelling findings. They have the ligands.
114	TRUE	TRUE	TRUE	FALSE
115	TRUE	TRUE	TRUE	TRUE	Intro to request 781: A researcher in Nigeria is using Nanopore technology to sequence SARS-COV-2 virus using the ARTIC protocol. However, they found out that their High-Fidelity polymerase will not work except they get a Q5 polymerase. Due to limited funds they can't buy the reagents themselves.
116	TRUE	TRUE	TRUE	TRUE	Task 781a: They are looking for an aliquot of Q5.
117	TRUE	TRUE	TRUE	TRUE	Task 781b: They are looking for a flongle.
118	TRUE	TRUE	TRUE	TRUE	Intro to request 780: A researcher in Indonesia wants to isolate SARS-COV2 virus from patient's samples. They already have experience isolating dengue virus. They want to discuss with an expert that could give them some tips for the isolation.
119	TRUE	TRUE	TRUE	TRUE	Task 780a: A researcher in Indonesia wants to isolate SARS-COV2 virus from patient's samples. They already have experience isolating dengue virus. They want to discuss with an expert that could give them some tips for the isolation.
120	TRUE	TRUE	TRUE	TRUE	Task 774a: A researcher in the UK is looking for a collaborator who can provide COVID19 positive and negative virus inactivated swabs for RNA-seq analysis from different risk groups (such as aged people, diabetics, etc) along with healthy individuals.
121	TRUE	TRUE	TRUE	TRUE	Intro to request 782: Researchers have founded an initiative that aims at centralizing the latest scientific literature on COVID-19 on a free dedicated website called â€œBiblioVidâ€ (https://bibliovid.org). To make their project more sustainable on the long run, they are looking for more collaborators.
122	TRUE	TRUE	TRUE	TRUE	Task 782a: They are mainly looking for Public Health Doctor/Resident or any motivated Doctor/resident or researchers to analyse and summarize some selected scientific articles on Covid-19 in english or in french.
123	TRUE	TRUE	TRUE	TRUE	Task 782b: They are looking for some bilingual doctors/researchers to translate this work from English to French or from French to English.
124	TRUE	TRUE	TRUE	TRUE	Intro to request 778: A researcher is looking for datasets consisting of extensive anonymous patient information. The most closely related database to what they are looking for is from the Korean initiative https://hira-covid19.net/. However, they still don't have access to the platform.
125	TRUE	TRUE	TRUE	TRUE	Task 778a: If you know of similar datasets please write it below.
126	TRUE	TRUE	TRUE	TRUE	Task 778b: If you have any experience accessing the Hira Covid 19 platform, please write it below.
127	TRUE	TRUE	TRUE	TRUE	Task 775a: A group developed a machine learning approach to identify PubMed abstracts related to COVID19. They would like to start a "Biomed News" webpage on this topic releasing one report weekly. They are looking for a researcher with interest on this topic that would be willing to manually inspect the outcome of the abstracts found with their automatic approach and select those more interesting for the scientific community.
128	TRUE	TRUE	TRUE	TRUE	Intro to request 770: A research group from London is studying the key cell biological mechanism(s) responsible for SARS-CoV-2 infection.
129	TRUE	TRUE	TRUE	TRUE	Task 770a: They are looking for a pseudotyped SARS-CoV-2 virus that is able to infect cultured cell lines, especially these: Calu-3, A549, and Vero E6.
130	TRUE	TRUE	TRUE	TRUE	Task 770b: They search collaborators with access to a live SAR-CoV-2 virus infection model to test 11 clinically approved drugs as potential blockers of SARS-CoV-2 endocytosis in vitro.
131	TRUE	TRUE	TRUE	TRUE	Task 772a: A research group in Texas is looking for non-human animal serum containing antibodies (suspected or confirmed) against SARS-CoV-2. All materials and shipping costs will be covered.
132	TRUE	TRUE	TRUE	TRUE	Intro to request 773: We at Crowdfight are improving our algorithms to automatically match requests and volunteers, so that we need to bother you less often with these e-mails. We need help with the following tasks:
133	TRUE	TRUE	TRUE	TRUE	Task 773a: We need a data scientist with experience in web scraping, to enrich our database with information from Google Scholar and similar public sources.
134	TRUE	TRUE	TRUE	TRUE	Task 773b: We need a full-stack developer to build an easy-to-use interface so that our coordinators can use a search engine developed in Python. Ideally you should know how to set it up in Docker (or be willing to learn).
135	TRUE	TRUE	TRUE	TRUE	Task 773c: We need a data scientist with experience with Python data visualization libraries to develop tools to explore our task and volunteer databases at different points of our workflow.
136	TRUE	TRUE	TRUE	TRUE	Task 766a: We at Crowdfight are updating our legal and privacy terms (nothing is changing; we just want to be more compliant with all regulations). We have a version in Spanish, and we need someone (ideally with legal background) who can translate them into Enlglish.
137	TRUE	TRUE	TRUE	TRUE	Intro to request 765: A researcher in Berlin is looking for some information on french death statistics.
138	TRUE	TRUE	TRUE	TRUE	Task 765a: The number of death reported for a given day is updated over time. He is looking for an estimate of the reporting delay in all-cause death reports (percentage of under-estimated deaths as a function of days since report). This could be obtained by finding the information in the literature or by estimating it from a series of past reports.
139	TRUE	TRUE	TRUE	TRUE	Task 765b: A source of COVID-19 deaths classified by death date (not the reporting date). If you already know of such a source, please write it below.
140	TRUE	TRUE	TRUE	TRUE	Intro task 757a: A research centre has initiated a large-scale open-community effort to describe mechanisms of COVID-19 virus-host interaction to support the fast-track development of efficient treatments. It is joined by many groups and more than 190 members that are contributing (https://covid.pages.uni.lu/map_curation). This is described in a letter-type paper published a week ago in Nature Scientific Data https://doi.org/10.1038/s41597-020-0477-8.
141	TRUE	TRUE	TRUE	TRUE	Task 757a: They require help from designers, artists, scientific illustrators or aesthetically-inclined researchers to make the resource nice-looking, accessible for clinicians and biologists: help to create good colour schemes for diagrams, design the top-level view in a manner similar to Cell SnapShot Archive illustrations https://www.cell.com/snapshots.
142	TRUE	TRUE	TRUE	TRUE	Task 759a: A research group in the UK is seeking for collaborators who have/are able to obtain plasma and/or serum samples from hospitalised COVID-19 patients. This would optimally be a sample taken on hospital admission and have corresponding data to inform on patient outcomes.
143	TRUE	TRUE	TRUE	TRUE	Task 756a: A research centre has initiated a large-scale open-community effort to describe mechanisms of COVID-19 virus-host interaction to support the fast-track development of efficient treatments. It is joined by many groups and more than 190 members that are contributing (https://covid.pages.uni.lu/map_curation). They need help from MDs, clinicians and virologists to advise on the content of the resource. This is described in a letter-type paper published a week ago in Nature Scientific Data https://doi.org/10.1038/s41597-020-0477-8.
144	TRUE	TRUE	TRUE	TRUE	Task 753: A french research group is working on describing the mortality in homeless population due to COVID-19. In addition, they want to describe the spatiotemporal variation and cluster of COVID-19 in Marseille. They are looking for a researcher with the skill on cluster analysis (notably SaTSan) to help them with their analysis.
145	TRUE	TRUE	TRUE	TRUE	Task 760a: A non-profit in the USA is performing covid-19 free tests (https://www.sciencedemandsaction.org/btrrt). In order to obtain reagents and other materials, they need volunteers who can help them screen vendors and biotech companies for their COVID19 supply donation programs. This may require making phone calls to US locations (especially in NY), so being in the US is an advantage.
146	TRUE	TRUE	TRUE	TRUE	Intro to request 700: A research group in Canada is seeking collaborations to test different technologies they developed:
147	TRUE	TRUE	TRUE	TRUE	Task 700a: They are developing a new diagnostic test device based on a patented technology in their group and they need to test the device on real samples. They look for collaborators that can bring the device to their lab for tests, having the capability for doing the reverse transcription polymerase chain reaction on the same samples that would be measured by the device, i.e. the lab should have the proper biosafety approval.
148	TRUE	TRUE	TRUE	TRUE	Task 700b: They are developing a new treatment method based on a medical device developed at the lab scale. To show this device is effective for treatment of Covid-19 patients they are validating the method with in vitro and ex-vivo animal test. They are looking for collaborations to do experiments on cells and tissues with Covid-2.
149	TRUE	TRUE	TRUE	TRUE	Intro to request 728: A research group in the USA is working on developing a database to expedite the development of SARS-CoV-2 antiviral therapy.
150	TRUE	TRUE	TRUE	TRUE	Task 728a: They are looking for highly trained persons in chemistry, virology, pharmacokinetics, and clinical trials to help them annotate the growing number of papers on coronavirus therapies and the growing list of studies in clinical trials registries.
151	TRUE	TRUE	TRUE	TRUE	Task 728b: They are looking for persons knowledgeable about monoclonal antibodies to help them create a database with experimental data on published monoclonal antibodies.
152	TRUE	TRUE	TRUE	TRUE	Task 728c: They are looking for persons knowledgeable about 3-D structures to help them create a section on published 3-D structures of the targets of antiviral therapy.
153	TRUE	TRUE	TRUE	TRUE	Task 728d: They are looking for a UI/UX developer with artistic talent to help them further develop their website.
154	TRUE	TRUE	TRUE	TRUE	Task 730a: A research group is looking for a collaboration outside Spain, to extend their project of gathering information on the emotional impact of the sanitary crisis and corresponding lock down measures that can facilitate evidence-based decision-making by political authorities and organisms responsible for psychosocial support. Ideally would be a group involved in mental health research, psychologists, social scientists, or behavioural economists.
155	TRUE	TRUE	TRUE	TRUE	Task 731a: An engineer working on developing a system of UV-C area lightning which might help to mitigate spread of the virus is looking for someone with a virological/epidemiological background to discuss his ideas with.
156	FALSE	FALSE	FALSE	FALSE
157	TRUE	TRUE	TRUE	TRUE	Task 708a: A research group has developed a computational method to classify patients based on cell-free DNA (cfDNA). They looking for a dataset of sequenced cell-free DNA from COVID-19 patients or for an experimental lab working with blood plasma of COVID-19 patients, which can extract cell-free DNA from blood plasma for sequencing.
158	TRUE	TRUE	TRUE	TRUE	Task 710a: A research group is examining the priority given to children and families in political and public health responses around the globe. They are looking for volunteers that could watch UK, Norway, Sweden and France daily-briefing by politicians and note down on standardised checklist specific points relating to children and families. They will provide this checklist. The volunteers needs to be native speakers and watch ~40 sessions.
159	TRUE	TRUE	TRUE	TRUE	Intro to request 720: Evidence shows that Black and Minority Ethic (BAME) groups are severely affected in comparison to non-BAME groups and present with differing symptoms and experiences. A researcher is looking for several collaborators to conduct (1) a research into how COVID-19 affects people from Black and Minority Ethnic (BAME) Groups based on qualitative research and (2) a systematic review of evidence to support how COVID-19 affects people of BAME background. They are looking for researchers with experience in conducting research into any of the following: Health, Health Sciences, Psychology, Health Inequalities, Black and Minority Ethnic Groups and Systematic reviews. Researchers involved in the study will have co-authorship for publications arising from these and will be involved in the writing process.
160	TRUE	TRUE	TRUE	TRUE	Task 720a: For the qualitative research they are looking for researchers that can help with remote access to people diagnosed with COVID-19 and assist with the recruitment via social media.
161	TRUE	TRUE	TRUE	TRUE	Task 720b: For the qualitative research they are looking for researchers that can transcribe and analyse data.
162	TRUE	TRUE	TRUE	TRUE	Task 720c: For the systematic review they are looking for researchers that have experience extracting data using PICO guide.
163	TRUE	TRUE	TRUE	TRUE	Task 720d: For the systematic review they are looking for researchers with experience in reporting data with PRISMA.
164	FALSE	FALSE	FALSE	FALSE
165	TRUE	TRUE	TRUE	TRUE	Task 707a: A research group doing serology on blood donors for NC, spike and RBD, are finding several positives. These people self-select as healthy, therefore they must have undergone asymptomatic or oligosymptomatic disease. They would like to recontact them and interview them for past COVID symptomes (anosmia, rash, diarrhea,etc). They need help in scouting the literature for every even most improbable anamnestic symptom that may be connected to Covid, and which should enter the questionnaire.
166	TRUE	TRUE	TRUE	TRUE	Task 702a: We have received several requests from groups developing materials with antiviral properties, who need collaborators to measure virus survival on the surface of their materials (the requesters would send their materials to these collaborators). We are looking for research groups with access to a BSL3 to titer virus survival after surface absorption, similarly to Van Dormalen 2020 (https://doi.org/10.1056/NEJMc2004973). If needed, we can complement the collaboration with missing expertise (e.g. virologists who can advise about protocols) or missing reagents (e.g. viral strains).
167	TRUE	TRUE	TRUE	TRUE	Task 701a: A research group monitoring the COVID19 response of different sectors has a list with the url's to the homepage of 7300 hospitals in the USA. They are looking for a collaborator who could automatically scrap those webs and find (1) The URL for each hospital's COVID-19 information page (2) the Twitter handle, and (3) the Facebook page.
168	FALSE	FALSE	FALSE	FALSE
169	TRUE	TRUE	TRUE	TRUE	Task 684a: A research group in London is looking for FFPE lung blocks from SARS-Cov-2 positive patients to look at gene expression of two panels of genes: an inflammation panel and a fibrosis panel.
170	TRUE	TRUE	TRUE	TRUE	Task 688a: A research group in France wants to identify the host cellular targets of SARS-CoV2 proteases, using specific degradomics protocols. They need around 1 mg of the two purified viral proteases : Main protease (Mpro) and papain-like protease (PLPro)
171	TRUE	TRUE	TRUE	TRUE	Task 685a: A research group in Nigeria has identified a number of plant-based compounds that interact with SARS-COV-2 target sites and would like to test them in vitro. They seek for any lab (they are open to collaboration) that can synthesize any of these two compounds: 1. Dammarenolic Acid 2. Scopadulic Acid
172	TRUE	TRUE	TRUE	TRUE	Intro to request 692: A PRIVATE COMPANY is working on an automatic detection of COVID on ultrasound recordings. The team has developed a deep learning model to classify ultrasound images
173	TRUE	TRUE	TRUE	TRUE	Task 692a: They are looking for legal advice regarding their webservice where people can upload images, data collection etc.
174	TRUE	TRUE	TRUE	TRUE	Task 692b: They are looking for someone experienced in web development that can help with React JS.
175	TRUE	TRUE	TRUE	TRUE	Task 692c: They are looking for someone to help with data collection of ultrasound images(healthy, with pneumonia or covid) through publications or other sources.
176	TRUE	TRUE	TRUE	TRUE	Task 692d: They are looking to collaborate with someone with experience in machine learning (in particular computer vision / medical image analysis)
177	FALSE	FALSE	FALSE	FALSE
178	TRUE	TRUE	TRUE	TRUE	Task 664a: A research group's preliminary analysis suggests that there may be a relationship between the expression of the S gene and days after onset of COVID-19. To confirm this, they need gene expression data of any S gene from coronaviruses and associated metadata that includes when the sample was taken in terms of days after onset of the disease
179	TRUE	TRUE	TRUE	TRUE	Intro to request 663: A research group from Portugal is developing materials with antiviral effects. They are looking for collaborators to test and certify their materials, with the possibility of applying for Portuguese and European funding together (collaborators should be in Europe). They need:
180	TRUE	TRUE	TRUE	TRUE	Task 663a: A collaborator who is familiar with the process to certify materials or personal protection equipment in the EU.
181	TRUE	TRUE	TRUE	TRUE	Task 663b: A collaborator who can help them assess experimentally the antiviral effect of their materials, by measuring survival of SARS-CoV-2 on their surface.
182	TRUE	TRUE	TRUE	TRUE	Task 678a: A research group in Nottingham (UK) is studying the role of ACE2 and integrins in Sars-Cov-2 infection. They are looking for human lung slices from COVID-19 patients' autopsies.
183	TRUE	TRUE	TRUE	TRUE	Task 668a: A research group in Paris wants to screen n FDA-approved library of 1040 molecules against the 23 proteins of SARS-CoV2. Their method is based on an innovative approach called switchSense and developed by Dynamic Biosensor (DBS). They need a small quantity of purified SARS-CoV2 proteins (200Âµg a 1mg/ml) to perform the screening.
184	TRUE	TRUE	TRUE	TRUE	Task 665b: A researcher from the USA needs the gene encoding for ACE-2.
185	FALSE	FALSE	FALSE	FALSE
186	TRUE	TRUE	TRUE	TRUE	Task 641a: A medical doctor from Canada wants to get in touch with people who have used the Nobivac-1-CV vaccine in animals (pets, zoo animals or laboratory animals) or cell cultures.
187	TRUE	TRUE	TRUE	TRUE	Intro to request 656: A research group has developed an NK-specific CAR that is specific, and functionally active. They aim to create CAR-NKs engineered with proteins (instead of scFV) that bind specific elements of SARS-CoV-2 envelope and test the cytotoxicity against virally infected cells as well as the decrease in viral loads. These specific proteins have been found to bind MERS coronavirus envelope.
188	TRUE	TRUE	TRUE	TRUE	Task 656a: They would like to find a collaborator lab that has developed respiratory epithelial cell models of SARS-CoV-2 infection, in order to test their immune cells against these models.
189	TRUE	TRUE	TRUE	TRUE	Task 656b: If above is not feasible, they would like to know if there are any plasmid(s) for SARS-CoV2 envelope proteins in order to create a pseudotyped virus (they use g-retroviruses to transduce their cells with the envelope of SARS-CoV-2) and try to infect cells themselves. Ideally they would need all proteins of the envelope.
190	TRUE	TRUE	TRUE	TRUE	Task 656c: They would like to know which assays could evaluate reduction in viral production and infectivity of cells, except of cytotoxicity of virally infected cells.
191	TRUE	TRUE	TRUE	TRUE	Task 666a: A researcher from the USA needs mouse DBT (delayed brain tumor) cells for propagation and titration of mouse hepatitis virus (MHV), a BSL2 surrogate coronavirus
192	TRUE	TRUE	TRUE	TRUE	Task 650a: A researcher group has developed an assay for screening of COVID19 through swabs. They would like to discuss with another group working with saliva samples to know more about inactivation and RNA extraction from saliva.
193	TRUE	TRUE	TRUE	TRUE	Task 647a: A research group is looking for an expert in medical statistics who can help them analysing the association of particular genetic variants and COVID19 infection in the Italian population.
194	TRUE	TRUE	TRUE	TRUE	Task 655a: A research group is working on an open-source project to improve the analysis of the RT-PCR results of the COVID19 tests. They are using machine learning to exploit the information of the times series of the fluorescent signal. To train their algorithm they are looking for collaborators that could provide them with: RT-PCR raw data with expert's interpretations, brand of the RT-PCR machine, name of the kit and primers and probes used to run the test.
195	TRUE	TRUE	TRUE	TRUE	Task 654a: A group of psychologists is developing a study about how social support attenuates the effects of stress during COVID-19 times. They want to investigate how context (social support from friends, community, family, pets, etc) moderates this association, specially with emerging adults (from 18 to 30 years old) in Brazil. They have the measures for social support and mental health (stress/anxiety), but they need help to find measures/scales that will work as indicators to assess social dynamics related to personal or collective initiatives to face the crisis (specifically of COVID-19). They are looking for someone who could help to indicate those measures or interview protocols.
196	FALSE	FALSE	FALSE	FALSE
197	TRUE	TRUE	TRUE	TRUE	Task 592a: A researcher is looking for survey-generated data about childhood maltreatment or parent-child relationship quality, collected during the COVID-19 pandemic. It would be helpful (but not necessary) that the data include COVID-19 related questions (such as symptoms), and/or mental health indicators of those in isolation. The researcher is interested either in publicly available data, or in collaborators who would like to share their dataset.
198	TRUE	TRUE	TRUE	TRUE	Task 611a: A research group is developing materials to improve health education. They are looking for collaborators to create a platform to distribute the materials, and also to improve some of them through gamification.
199	TRUE	TRUE	TRUE	TRUE	Intro to request 631: A research group in Haïti would like to test if plant extracts like Moringa or quercetin have the potential ability to inhibit replication of SARS-CoV2.
200	TRUE	TRUE	TRUE	TRUE	Task 631a: They need a literature search of the effect of Moringa extracts or quercetin on coronavirus (not necessarily SARS-CoV2). If you already know of any paper about this, please give the link below.
201	TRUE	TRUE	TRUE	TRUE	Task 631b: They are looking for a lab (preferably in Belgium) where they could send extracts to test them in-vitro against SARS-CoV2.
202	TRUE	TRUE	TRUE	TRUE	Task 629a: An unaffiliated researcher in Canada is looking for collaborators to test a treatment that should make regular cloth resist contamination by pathogens. She is looking for someone with access to a basic microbiology lab for testing. Simple diffusion or growth inhibition tests would be sufficient, and initial tests could be performed on microbes other than SARS-CoV-2.
203	TRUE	TRUE	TRUE	TRUE	Intro to request 639: A PRIVATE COMPANY with a platform for low-cost simplified vaccine production is looking for collaborators.
204	TRUE	TRUE	TRUE	TRUE	Task 639a: They are looking for collaborators who are developing vaccines for COVID-19 but also for other pathogens, in order to evaluate their platform.
205	TRUE	TRUE	TRUE	TRUE	Task 639b: They need guidance on what sequence to use for the SARS-CoV2 antigen in their construct for recombinant vaccine (full spike S protein? Only part of it? Any other target?)
206	TRUE	TRUE	TRUE	TRUE	Intro to request 608: A research group is investigating whether COVID-19 infection changes the expression of circRNAs and other non coding-RNAs. They are looking for:
207	TRUE	TRUE	TRUE	TRUE	Task 608a: Data sets generated from total rRNA depleted libraries obtained from cell lines, animals, or patients infected with COVID-19
208	TRUE	TRUE	TRUE	TRUE	Task 608b: Total RNA samples from cell lines, animals (control vs infected), or human samples (patients vs control) to generate rRNA depleted libraries.
209	TRUE	TRUE	TRUE	TRUE	Intro to request 619: Copper surfaces have already been demonstrated to have the most pronounced effect in reducing surface viral load/killing virus, measured by end-point titration on Vero E6 cells. A PRIVATE COMPANY working with nanomaterials wants to test if silver or silver/copper hybrid coatings can reduce virus survival on surfaces of objects such as door handles.
210	TRUE	TRUE	TRUE	TRUE	Task 619a: They want to contact a virologist to discuss their ideas and experimental design
211	TRUE	TRUE	TRUE	TRUE	Task 619b: They are also looking for a collaborator who can make the experiments of virus suvival on the pieces they would provide, using techniques such as those described in https://www.nejm.org/doi/full/10.1056/nejmc2004973. Ideally these tests would be performed directly on SARS-CoV2, but they are open to test on other viruses first, if results can be useful to predict effect on SARS-CoV2.
212	TRUE	TRUE	TRUE	TRUE	Task 630a: A medical institute in Burundi is looking for someone (preferably french speaking) to conduct distance training for 6 laboratory technicians in the use of COVID-19 diagnostic equipment, in particular TIANLONG Gentier 96 E PCR machines and TIANLONG Model Libex extractor. They would also need some advice about calibration kits for extraction and amplification on the TIANLONG machines mentioned before.
213	TRUE	TRUE	TRUE	TRUE
214	TRUE	TRUE	TRUE	TRUE	Task 606a: A researcher would like to get in touch with laboratories working with Sars-CoV-2 that use Thermo Fisher Quantstudio 7-12 qPCR cyclers, in order to get input from their experience.
215	TRUE	TRUE	TRUE	TRUE	Task 616a: A researcher is looking for protocols to extract RNA for sequencing from nasal swab samples (they want to characterize the cells, not the virus).
216	TRUE	TRUE	TRUE	TRUE	Intro to request 607: A research group wants to catalog social distancing measures taken in Portugal. To do so, they want to extract all Facebook posts published in public official Facebook pages of 308 municipalities since March 1, 2020.
217	TRUE	TRUE	TRUE	TRUE	Task 607a: Do you know how to do this automatically, and would you be available to help do it?
218	TRUE	TRUE	TRUE	TRUE	Task 607b: In case we don't find an automatic way, would you be available to help doing it manually?
219	TRUE	TRUE	TRUE	TRUE	Intro to request 385: A group of researchers needs to compile a database of human mobility and its impact on COVID-19. They want to compile city-wise information about the following variables: (1) Reported number of infections (per city as opposed to the whole state/country). (2) Number of travelers between cities/villages (daily). (4) Number of beds per 1000 people or other infrastructure of the city which directly effects its health system). They are mainly focused on Asian least developed countries (https://en.wikipedia.org/wiki/Least_developed_countries#Asia)
220	TRUE	TRUE	TRUE	TRUE	Task 385a: Do you know where to obtain any of these data at the level of individual cities? (Please explain below)
221	TRUE	TRUE	TRUE	TRUE	Task 385b: This task will probably require substantial manual work to compile the database from different public sources. Would you be available for this work?
222	TRUE	TRUE	TRUE	TRUE	Task 615a: A bioinformatics group is trying to apply WGCNA algorithms to the study of COVID-19. They are looking for collaborators who can share host RNAseq data from infected individuals. Human data would be most helpful, but they can also work with data from animal models or cell lines. They would need at least 40-50 samples (the more the better).
223	TRUE	TRUE	TRUE	TRUE
224	TRUE	TRUE	TRUE	TRUE	Task 598a: A research group in France is setting up a SARS-CoV-2 pseudovirus system to handle viruses in BSL2 for inhibitor screening. They are looking for spike S expression plasmid with CMV promotor (pCMV3 for example).
225	TRUE	TRUE	TRUE	TRUE	Task 590a: A researcher is exploring the possibility of using selected phages (instead of anti-bodies) to detect COVID-19 antigens in ELISA. Phages have been used earlier for ELISA (https://pubmed.ncbi.nlm.nih.gov/26472318/) with the advantage of lower cost, ease of production and greater affinity. He is looking for any researchers with experience in phage display to discuss these ideas.
226	TRUE	TRUE	TRUE	TRUE	Task 586a: A researcher from Virginia (USA) needs urgently Bioquell chemical indicators (http://www.labnetworkstore.com.tr/brosur/bioquell-hpv-ci-kimyasal-indikator.pdf). Backorder from the manufacturer won't be available until the end of April, and most distributors have run out of stock. They are looking for any lab or institution that could loan them part of their stock (they will give it back as soon as they receive the new shipment). They would need between 25 and 400 indicators, but they would be happy with any number they can get.
227	TRUE	TRUE	TRUE	TRUE	Task 600a: A medical doctor is working on a project to assess the efficacy of different lockdown measures. He wants to analyze country-wise epidemiological data (from the Johns Hopkins repository), combined with social isolation indexes computed by his institution. He is looking for epidemiologists, mathematicians or statisticians to help with the mathematical modeling (statistical data analysis, computation of epidemiological parameters such as R0, etc.). Programming in R would be a plus, as it would facilitate the collaboration.
228	FALSE	FALSE	FALSE	FALSE
229	TRUE	TRUE	TRUE	TRUE	Intro to request 421: A researcher specialized in social network analysis is studying the human and social perspectives in connection with COVID19 pandemic. He is looking for potential collaborators who can provide information about the following issues:
230	TRUE	TRUE	TRUE	TRUE	Task 421a: Reports/statistics about viruses treatments for current and previous corona viruses. E.g. reports from labs, clinics, hospitals, etc.
231	TRUE	TRUE	TRUE	TRUE	Task 421b: Reports on corona viruses treatments and drugs chemicals, and any structural relations between those drugs and treatments
232	TRUE	TRUE	TRUE	TRUE	Task 421c: Any data on NPI procedures around the world and their effectiveness in terms of impacts on counts of corona reported cases
233	TRUE	TRUE	TRUE	TRUE	Task 573a: I would like to characterize experimentally nucleocapsid protein N of virus SARS-CoV2 to find conditions for the destabilization of this protein as potentially helpful to fight with COVID-19. I need any vector containing cDNA of SARS-CoV2 nucleocapsid protein N as a template for amplification and cloning into selected expression vectors.
234	TRUE	TRUE	TRUE	TRUE	Task 571a: A group of researchers have started a platform that uses surveys to evaluate the reach of the pandemic (https://coronasurveys.org/). They need help to translate the survey (<350 words) into other languages. They already have English, Spanish, French, Portuguese, Italian, Japanese, Ukranian, German, Farsi and Arabic, so translators can go from any of these languages into any other language. The most pressing ones are those used in large countries (Hindi, Urdu, Chinese, etc.) but any language is welcome. If you can help with this task, please specify from what language(s) and into what language(s) you can make the translation. Also, please specify your level of proficiency with each of the languages (which ones are mother tongue, etc.).
235	TRUE	TRUE	TRUE	TRUE	Task 569a: A team of engineers (part of them belonging to a private company) is designing an open-source cheap ventilator, aiming to produce 10 K ventilators per month at $700 apiece. They need someone with expertise in video editing to help them put together a documentary they are preparing in order to secure extra funding.
236	TRUE	TRUE	TRUE	TRUE	Task 567a: A researcher is looking for human DNA sequences (whole genome sequences if possible) from people infected by SARS-CoV2, if possible annotated by severity of the disease in each subject.
237	TRUE	TRUE	TRUE	TRUE	Task 548a: A data analyst from a pediatric hospital would like to model pediatric cases and staffing changes during social distancing interventions. They would need reports about how different institutions coped with the situation, particularly from places with a high number of COVID cases (China, Italy, New York, Washington, California...) as well as any raw data regarding pediatric patient admissions, the length of stay/discharge date, whether they get tested and the result.
238	TRUE	TRUE	TRUE	TRUE
239	TRUE	TRUE	TRUE	TRUE	Intro to request 556: A research team is trying to set-up a robotized pipeline to increase throughput of qPCR diagnostics, up to 10 000 per day. The current bottleneck is handling the sample tubes containing the swab stick (these tubes must be opened one by one, the stick removed, and a sample transferred to a multi-plate). They would like to discuss with people knowledgeable in the following topics:
240	TRUE	TRUE	TRUE	TRUE	Task 556a: Someone with direct experience of transferring swab fluid to a 96/384 format in a very high-throughput manner and/or with direct experience of automation equipment for uncapping tubes (especially those with a swab stick attached to the lid, as this requires extra z-clearance). Ideally, but not necessarily, decapping and and sample transfer would be integrated in a single machine. Ideally, but not necessarily, the equipment would perform sample tracking automatically.
241	TRUE	TRUE	TRUE	TRUE	Task 556b: Someone who knows of soluble/dissolveable swabs, swabs that can be broken to lie beneath the liquid surface or experience in use of FTA cards for clinical virology.
242	TRUE	TRUE	TRUE	TRUE	Task 556c: Someone who knows of swab collection formats that allow for direct downstream automated liquid handling (e.g. swab collectors already prepared as 96 well plates or arrayed 1.5mL tubes).
243	TRUE	TRUE	TRUE	TRUE	Task 556d: Someone with direct experience on pierceable lids for high throughput automated downstream processing without opening the swab tubes, along with the necessary handling robots.
244	TRUE	TRUE	TRUE	TRUE	Task 551a: A physician in Minnesota (USA) is testing a device to allow sharing of a single ventilator among multiple patients. They are seeking to borrow 5 test lungs with adjustable compliance and resistance. Examples of such test lungs include the QuickLung (Ingmar Medical), Linear Test Lung (Ingmar Medical), SmartLung (IMT Analytics), AccuLung (Fluke Biomedical), TTL/ training test lung (Michigan Instruments). They would return them promptly after 2 days of use.
245	TRUE	TRUE	TRUE	TRUE	Task 527a: A research team requires input on the inactivation of COVID in samples of blood, sputum, feces, and urine for FACS and single-cell procedures. This inactivation needs to be done without damaging the cells and their plasma membrane (no fixative such as methanol of flash freezing allowed) to use samples in BSL2 for staining/magnetic sorting/FACS sorting/single-cell RNA-Seq. They cannot fix cells in PFA for single cell RNA-Seq.
246	TRUE	TRUE	TRUE	TRUE	Task 550a: A foundation, in partnership with a coalition of NGOs working in Syria, need researchers to help them modeling the Covid-19 impact for refugees living in IDP camps in North West Syria. They can provide many data and qualitative insights. They look for experienced epidemiologists and people with mathematical and statistical skills. The aim is to develop a realistic response strategy to prevent infection of most vulnerable populations by SARS-CoV-2. Someone able to speak French would be appreciated but it is not a requirement.
247	TRUE	TRUE	TRUE	TRUE	Task 529a: A German PRIVATE COMPANY producing DNA and RNA extraction kits for COVID-19 tests. They need proteinase K to produce those kits, but they are in high demand right now. They need a supplier in Germany (or able to ship to Germany) with proteinase K available.
248	TRUE	TRUE	TRUE	TRUE	Task 539a: A registered not-for-profit company in the UK that aim to launch a new platform to connect researchers in biotech and pharma with biospecimen providers. Their main focus now is Covid-19 research. Their web developer company has found a problem in the database design (database is relational, MariaDB). They need advice from someone with relevant informatics experience.
249	TRUE	TRUE	TRUE	TRUE	Task 543a: A researcher is looking for a molecular modeler/structural biologist/bioinformatician that use information from the amino acid sequence and crystal structure of the S1 subunit to determine its charge characteristics (and how the charge is spaced over the protein surface). This information is required to perform the simulation of Field-Effect Transistor (FET) based biosensors and evaluate their capabilities for the detection of this specific protein attached to the COVID-19.
250	TRUE	TRUE	TRUE	TRUE	Task 554a: A research group has developed a deep neural network that can retrieve the BVP (blood volume pulse) from videos of the face of subjects. They believe that this model can be adapted to electro-cardiograms (ECG). In particular, if such a model was embedded on portable devices, people would be able to take these measures at home and send them directly to their physicians. This would be useful if ECG devices are missing, and would avoid interactions between contagious people and nurses/doctors. Several promising treatments for COVID-19 involve the use of Hexa-Chloroquine, but some potential cardiac side effects require close monitoring with ECG of the patient, in order to detect possible long QTc. They need a collaborator that can gather simultaneous recordings of ECG and videos of the face of a large number of patients (with regular webcam(s) of computer/mobile device(s) at 30 frames/second). It would be useful to also have the BVP measured with a photoplethysmograph. It is important that patients with long QT form a big proportion of the cohort, as the objective of the model is to detect long QTc. In a second phase, they would need someone who can tag the QT interval on these records.
251	TRUE	TRUE	TRUE	TRUE	Task 533a: A medical doctor is aware of a coronavirus vaccine applied to animals, and is interested in discussing with veterinarian researchers who would share their data if they saw benefit with this vaccine in animals with COVID-19.
252	TRUE	TRUE	TRUE	TRUE	Task 546a: A researcher is interested in analyzing the effect of COVID-19 on Aviation industry, and needs to know where to find the most recent data (on daily level) on airlines' operation schedules, number of air travelers through different airports and number of ticket cancellations over the last few months (or even better, years).
253	TRUE	TRUE	TRUE	TRUE	Intro to request 557: A research team of CS+Bioscience aims to build a multi-purpose phone app that will support multiple aspects to reduce pandemic spreading. It will have a module for medical professionals to select parameters for pooled testing based on the expected positivity rate and the actual test technology to be used. It will provide support for pool designation, user tracking within pools and doctor/user notification of results. The app will also be combined advanced privacy-enhanced techniques and content to support the mental health and coping self-efficacy of both end-users and medical professionals. They are submitting a proposal for funding for this effort on April 15, but they we will continue to seek partners even after submission, especially for the secondary feedback task. The group looks for:
254	TRUE	TRUE	TRUE	TRUE	Task 557a: Operational testing partners doing COVID testing to evaluate new software to support enhanced efficiency pooled testing (ideally someone with rapid testing facilities with low positivity rates for which the design provides great efficiency gains, but also happy to partner with other operational groups). They are budgeting for paying standard testing fees plus a fixed fee for some of the partner's time. The ideal partner could also run validation testing and join them on a publication, but that is not required.
255	TRUE	TRUE	TRUE	TRUE	Task 557b: Operational users willing to provide feedback on their app design ideas and what they think would and would not work well in an operational setting. This would be answering a survey a few times throughout the software development cycle and probably being a beta tester.
256	TRUE	TRUE	TRUE	TRUE
257	TRUE	TRUE	TRUE	TRUE	Task 538a: A researcher in France would like to purify the recombinant full length Spike (surface glycoprotein of 2019-nCoV) and needs someone that could share the cDNA for cloning.
258	TRUE	TRUE	TRUE	TRUE	Task 536a: A researcher in Germany needs to know where to find (or buy) a positive RNA control for E-gene of Sars-CoV-2.
259	TRUE	TRUE	TRUE	TRUE	Intro to request 532: An European researcher has designed a potential vaccine strategy against COVID-19 that would be safe fast, and easy to implement if it works. In order to apply for grants to develop it, the researcher would need:
260	TRUE	TRUE	TRUE	TRUE	Task 532a: Anyone with experience designing clinical trials that might assist in writing that part.
261	TRUE	TRUE	TRUE	TRUE	Task 532b: Anyone able to find potential vaccine funding from international agencies (specially from the European Union).
262	TRUE	TRUE	TRUE	TRUE	Task 528a: A researcher in California (USA) needs to find a validated ELISA test w/ protocol (academic or commercial) to identify the SARS-CoV-2 (S) Spike protein. They prefer to buy kit from a commercial source or be able to quickly assemble a kit. They need to measure truncated versions of the S protein secretion in cell culture (S1, S2, Full - listed in order of importance). They are open to quantitative or a semi-quantitative readout. Their priorities are first ease of use of the protocol and second, throughput. Due to restrictions they have limited personnel available to run assays.
263	TRUE	TRUE	TRUE	TRUE	Task 526a: A researcher with extensive experience in microparticle design for cancer cell targeting has a protocol ready to repurpose the microparticles for vaccine preparation. He is looking for pharma companies (or research groups close to the pharma production stage) interested in this approach.
264	TRUE	TRUE	TRUE	TRUE	Task 511a: A medical doctor would like to know if medical doctors in any country are currently using surfactant of any type with COVID-19 patients and if it is being successful. If it is the case, could preliminary data be shared?
265	TRUE	TRUE	TRUE	TRUE	Task 507a: A group in Northampton (England) is setting up a laboratory to help with the efforts to test samples for COVID-19. They have everything to get started except an automated RNA extraction platform. Ideally they are after a KingFisher Flex as this is compatible with the RNA isolation kits they have, however any open system would be a major benefit to their testing efforts. As many laboratories, research facilities and university labs are currently closed due to social-isolation, they have thought there may be an automated platform available (that is currently not in use) to be lent to them.
266	TRUE	TRUE	TRUE	TRUE	Task 420a: An European PRIVATE COMPANY has has developed a high sensitivity immunofluorescence assay for COVID19. It consists on slides containing advanced nanostructures on the top surface. These nanostructures enhance microscope images and enable to visualize the virus-cell structures and bio-molecules (fats, lipids, proteins, etc.) at enhanced accuracy and enables real-time video imaging of live virus-cells. They are looking for an academic or industrial collaboration to test our device for COVID19.
267	TRUE	TRUE	TRUE	TRUE
268	TRUE	TRUE	TRUE	TRUE	Task 524a: A research group in Belfast (Northern Ireland) need Vero R6 cells for a COVID-19 research project, because stockist have a delay in shipment. They can provide their DHL account number to cover the shipment costs.
269	TRUE	TRUE	TRUE	TRUE	Task 518a: A group in Belgium just started working on COVID-19 research. They need contacting with other teams working on SARS-Cov2 to get information about where they can order genetic resources (like viral gene fragments) to be delivered as fast as possible
270	TRUE	TRUE	TRUE	TRUE	Task 525a: A research team is looking for a collaboration with an expert in epidemiology that could provide data regarding the lifestyle (physical activity, smoking...) of young healthy individuals that showed severe disease outcome after contracting COVID-19. These data will complement a study that the team is carrying out.
271	TRUE	TRUE	TRUE	TRUE	Task 450a: A researcher from the UK needs ~500 g Cyclopentadienyl manganese tricarbonyl (CAS number 12079-65-1) at an affordable price (<500 € for the 500 g). This probably needs to be purchased directly from a manufacturer, most of which are in china (for example, http://www.zkchem.net/). We need a volunteer who can find a manufacturer and contact them to ensure that they can ship the product to the UK.
272	TRUE	TRUE	TRUE	TRUE	Task 484a: A research team is exploring the idea that the nanofibrous scaffold containing nanoparticles that are produced via the electrospinning technique could be introduced as an effective technique to fabricate antiviral filters for health workers. They can perform the synthesis of nanoparticles, the incorporation of these nanoparticles into a polymer and the production of this polymer in nanofibers form. They need a collaborator who can test their antibacterial and antiviral activity. They suggest this examination could be done on COVID-19 or on other respirator viruses including SARS or influenza virus.
273	TRUE	TRUE	TRUE	TRUE	Task 500a: A researcher at the Consiglio Nazionale delle Ricerche (CNR, Italy) is designing a simulation study, and is looking for an expert in virology to discuss about: (1) coronavirus replication speed in cell/organism, (2) virus RNA mutation mechanisms and rate (virus evolution), (3) a method to map expressed RNA to a list of candidate human cell receptors
274	TRUE	TRUE	TRUE	TRUE	Task 520a: A researcher in South Africa is designing a survey on COVID-19 patients (to develop a smartphone app), and needs help to know how to structure an online survey to satisfy ethics review boards' requirement for obtaining informed consent (as opposed to traditional surveys, in which for example a requirement is that the subject can ask questions)
275	TRUE	TRUE	TRUE	TRUE	Task 253a: A researcher is examining how cross-cultural social and psychological indicators are correlated with covid-19 international responses and outcomes. They need help to collect different data, and accurately enter and organize data in a spreadsheet by country. Quantitative social science research and Statistical analysis experience desired, but not required.
276	TRUE	TRUE	TRUE	TRUE	Task 460a: A PRIVATE COMPANY has collected some evidence from the literature that the combination of three physiotherapeutic methods including EHF band (mm length waves) might help prevent infections (when used in combination) through developing the immune response. The efficacy of the method was tested in a number of previous infections but not on coronavirus. They need help from an expert to develop a study design to test this method on COVID-19.
277	TRUE	TRUE	TRUE	TRUE	Task 499a: A researcher would like to learn more about potential long-term effects of SARS-CoV-2 on healthspan and lifespan in mouse models predisposed to Alzheimer's pathology. The facilities they have access to are not designed for BSL-3, so they consider the options of using a pseudotype entry virus or a heat-inactivated virus. They are looking for a virology expert to discuss their study design.
278	TRUE	TRUE	TRUE	TRUE	Task 509a: A Biomedical Research Centre is assessing how an existing digital public health intervention can be very rapidly adapted and optimised for the changing needs of the COVID-19 pandemic infection outbreak. They are using novel participatory-co-design methods and are launching a website in sereval languages to be used around the world. They look for Polish and Japanese natives with a very good command of English to translate and backtranslate (to be done by different persons). They cannot pay for the translations.
279	TRUE	TRUE	TRUE	TRUE	Task 513a: A researcher is looking for a protocol to inactivate the virus from respiratory samples (as bronchoalveolar lavage, nasal wash and plasma) to measure cytokines, do FACS and RNAseq. P3 (BSL-3) access is complex and limited personel has been trainned for that, so they'd like to inactivate the samples in a P3 (BSL-3) and then work with inactivated samples in P2 (BSL-2).
280	TRUE	TRUE	TRUE	TRUE
281	TRUE	TRUE	TRUE	TRUE	Task 493a: A researcher is searching for collaborators that could send them plasmids: GSS-Polymerases and Uracil DNA Glycosylases
282	TRUE	TRUE	TRUE	TRUE	Task 485a: A group is looking for four Chinese fluent individuals (both Mandarin and Cantonese) to review a large volume of Chinese-language scientific articles on COVID-19. This task is simple but requires high comfort in both Chinese and scientific medical language. We need these studies assessed against eligibility criteria for a systematic review on COVID-19. The inclusion criteria that the volunteers need to evaluate in the publications are: (1) Study presenting original research data (anything that is not a review, viewpoint, editorial, etc) (2) On patients diagnosed with COVID-19 (diagnoses established by any criteria or test) (3) With sample size of either 5 patients or more
283	TRUE	TRUE	TRUE	TRUE	Task 468a: A PRIVATE COMPANY needs collaborators capable of running in vivo testing (pre-clinical safety and efficacy) of a Heparin nanoparticles based treatment for COVID-19. Collaborators are expected to select the animal models and perform the specific testing. The proposed treatment consists of engineered nanoparticles that are anti-inflammatory in nature and have affinity for the spike protein on SARS-CoV-2. The proposed delivery mechanism would be through inhalation of an aerosolized aqueous nanoparticle solution. The nanoparticles have the same size and charge as the virus, hence it is hoped that the transport into the lung will be similar and that the nanoparticles will be delivered locally and directly to the site of infection. The material is ready for testing and we can ship to a collaborator as soon as one is identified.
284	TRUE	TRUE	TRUE	TRUE	Task 399a: I am looking to study the effect of COVID-19 on Emergency Medicine specialist training residency in Singapore, together with a group of residency stakeholders from hospitals across Singapore. The research focus is being discussed. We are likely to focus on factors that enhance training adaptation and resiliency even in the face of COVID-19 and other pandemics. We think that a qualitative or semiqualitative research methods would be suitable, given this broad and exploratory research question, but what we lack is an experienced an available facilitator to train us in such methods, so that we can conduct the study in a methodologically rigorous fashion. Thus, I would need an expert in Medical Education and in qualitative or semicualitate methods, who can help us to study how our postgraduate medical education system can be made resilient.
285	TRUE	TRUE	TRUE	TRUE	Intro to request 463: A researcher would like to understand the link between the distribution of COVID-19 cases and the incidence of strokes (incidence of strokes has changed in Italy during the pandemic). Programming health care requires to know if the diffusion of covid19 is greater in countries where the burden of non infectious disorders is higher. The researcher needs:
286	TRUE	TRUE	TRUE	TRUE	Task 463a: An expert to help modeling the transport in the Stroke Service Planning adapted to the COVID-19 pandemic using geographic visualization (since the pandemic situation has changed the way to approach in the triage of stroke patients)
287	TRUE	TRUE	TRUE	TRUE	Task 463b: An expert to help comparing the mapping of stroke incidence worldwide using the GBD data and the actual COVID-19 distribution to see if there is a correlation and if it is possible to predict the impact of the pandemic on the triage stroke service.
288	TRUE	TRUE	TRUE	TRUE	Task 495a: A researcher is asking for a compiled list of every shotgun metagenomic RNA sequencing (with Illumina or Nanopore sequencing) data set obtained from respiratory (nasal, throat, or pulmonary) sampling and any associated papers describing them, including those sampled in any time in 2019 and early 2020
289	TRUE	TRUE	TRUE	TRUE
290	TRUE	TRUE	TRUE	TRUE	Task 379a: I am currently researching a vaccine against Covid-19. But I have trouble getting the supplies I need, because I cannot find distributors that ship them to Iran. Do you know of any? These are the reagents I need: (1) LEGENDplex™ Mouse Th1/Th2 Panel (8-plex) with Filter Plate V02 (Biolegend, cat. number 740750) (2) LEGENDplex™ Mouse Cytokine Panel 2 (13-plex) (Biolegend, cat. number 740134) (3) in vivo-jetPEI®(Polyplus, cat number 201-50g) (4) Lipofectamin (Thermofisher, cat number 15338500) (5) Plasmid Transfection Medium (Santacruz, cat number sc-108062) (6) Plasmid Transfection Reagent (Santacruz, cat number sc-108061) (7) ViaFect Transfection Reagent (promega cat number E4981) (8) Recombinat protein E (ProSci cat number 97-082) (9) Recombinat protein M (ProSci cat number 97-078) (10) Recombinat protein S (AmsBio cat number AMS.SPNC52H4-100ug) (11) Plasmid extraction (fermentase cat number K05503). If you know of a distributor that may ship any of these reagents to Iran, please let us know.
291	TRUE	TRUE	TRUE	TRUE	Intro to request 414: We are attempting to prototype a detection module using RNA Toehold switches. We aim to use GFP reporter constructs as protoypes while we switch to other visible light readouts for point of care diagnostics.
292	TRUE	TRUE	TRUE	TRUE	Task 414a: What regions of the SARS-CoV-2 RNA+ genome should be ideally targetted of 20 bps length for detection in nucleic acid detection? We are aware there are published PCR primers, but can somebody point us to a comparative study of the detection optimality?
293	TRUE	TRUE	TRUE	TRUE	Task 414b: Help designing toehold RNA sequences for SARS-CoV-2
294	TRUE	TRUE	TRUE	TRUE	Task 472a: The aim of our project is to improve the triage of COVID-19 patients. Currently, the health system is being over-run by a huge number of patients. We are developing a system to help clinicians to perform accurate triage. This allows doctors to identify high-risk patients, and determine which patients can be safely sent home for quarantine, and which patients need urgent admission to ICU. We are seeking help with the analysis. We are looking for a statistician who has experience in exploring clinical data. The clinical data are from observational studies (not randomised controlled trials). The aim of the analysis is to predict outcome (e.g. ICU admission, mortality) using clinical variables and/or biomarker variables. We need someone with expertise in (1) prediction modelling, or (2) longitudinal data analysis, or (3) multivariate regression analysis.
295	TRUE	TRUE	TRUE	TRUE	Task 474a: We are looking for volunteers that would like to form a team that would help us to increase our capacity for covid testing in South Bohemia / Vysočina. Currently we have 3 teams of 3 skilled people and need at least 1-2 more. The team should consist of 1 person experienced in working with infectous material (BSL2 - 3) for RNA isolation and 2 people with experience in molecular biology (RT-PCR). The procedures are relatively simple, no big science, just be precise and responsible. Now we perform 50-70 tests per day. Volunteers will get free accomodation in apartments in Trebon Spa during their work for us.
296	TRUE	TRUE	TRUE	TRUE	Intro to request 479: In looking at the COVID-19 genome, I found a conserved 3' element at the very end of the viral genome. I've attached a conservation map (s2M.pdf) and the COVID-19 (COVID.pdf) specific element to this email. The s2M motif has evidence that it is processed by Dicer/DGCR8 in cells to allow for proper viral genome assembly. However, this motif also has a miRNA-mimic that can be liberated from it, resembling miR-1307-3p. Instances of dysregulation of miR-1307-3p have been known to result in increased pulmonary hypertension and often necessitate ECMO usage, which is strikingly similar to the patient phenotypes of folks who have severe COVID-19 infections. I am wondering if there is any validity to this hypothesis, as there may be an avenue of attack to stop the viral infection. Either by stopping/inhibiting Dicer/DGCR8, inhibiting miR-1307, or enhancing the targets of miR-1307, one of which is a MAPK.
297	TRUE	TRUE	TRUE	TRUE	Task 479a: I would like to discuss these hypotheses with a pulmonologist with a bit of experience with miRNA, whether that is in the form of lung cancer or lung diseases in general.
298	TRUE	TRUE	TRUE	TRUE	Task 479b: I would like to discuss these hypotheses with a virologist who has some expertise in RNA viruses
299	TRUE	TRUE	TRUE	TRUE	Task 469a: Our team's expertise is the synthesis of nanoparticles, which are ideal candidates to be integrated in a fast test set up for SARS-CoV-2 detection. We do have the chemical expertise and daily routine in producing those particles, which are synthesized in a very efficient and reproducible manner in our laboratory. Hence, we are searching for a cooperation partner for a project proposal for the point of care detection of SARS-CoV-2. We search a molecular biologist, virologist, epidemiologist or clinician, who has the expertise to work with coronavirus and its antigens on the required safety level.
300	TRUE	TRUE	TRUE	TRUE	Task 459a: My lab is working to address the question of why >25% of patients who have positive tests for COVID-19 do not show any symptoms. We would need clinical samples for bioinformatics analysis. We would be interested in blood samples, lung tissue from biopsies, or potentially nasal swabs. If there are existing transcriptomic and other bioinformatic datasets that have been collected, that would be ideal since we could start doing analysis immediately. However, we also have the ability to collect this data from biological samples if there is a repository of samples that have been collected or if there is somebody who could collect and send us samples from the populations we want to analyze. These populations are: (1) Individuals who tested positive for the COVID virus but who were asymptomatic (2) patients who show mild symptoms (3) patients with severe symptoms (the most important)
301	TRUE	TRUE	TRUE	TRUE	Task 334a: We want to develop an app that allows people at home to record a diary with eventual symptoms and meds they’re taking by order of their doctor. Linking these data to the person profile (age, gender, habits, existing pathologies) the app can compute a risk factor, by means of a probabilistic algorithm, that can tell how much a person is likely to have COVID-19. The risk is then updated after every new insertion of symptoms and or meds. In order to build and validate our predictive model, we need clinical data about signs and symptoms of people with and without a positive Covid19 test (cough, shortness of breath, fever, and also oxygen saturation, age, BMI, sex, comorbidities...)
302	TRUE	TRUE	TRUE	TRUE	Task 438a: We would like to request assistance from a behavioral health specialist who is familiar with qualitative and self-efficacy research and surveys to help with designing a valid self-efficacy questionnaire for parents of children with type 1 diabetes and the effect of the pandemic on their daily lives
303	TRUE	TRUE	TRUE	TRUE	Task 471a: [PRIVATE COMPANY] We are developing some recombinant antigens to use in IVD test for rapid detection of COVID-19. We need access to serum from recovered patients to test if our proteins are able to detect antibodies IgG and/or IgM.
304	TRUE	TRUE	TRUE	TRUE	Task 371a: [PRIVATE COMPANY] I would like to know the complement levels (CH50, C3, C4 and any other complement levels) in the ICU patients with COVID19. A simple measurement of these levels in a handful of ICU patients with COVID19 would help clarify the potential role a couple of drugs in development and on the market. Collaborators are welcome.
305	TRUE	TRUE	TRUE	TRUE	Task 444a: I need volunteers to answer questions about coronavirus from residents in Congo Kinshasa (the volunteers can be located anywhere in the world). I need around 50 volunteers who are health professionals and can reply questions of patients over the internet (website: http://hello-clinic.azurewebsites.net). Volunteers must speak one of these languages: english, spanish, french and sawahili (please, state the language you speak in your response below)
306	TRUE	TRUE	TRUE	TRUE	Intro to request 415: [PRIVATE COMPANY] Our group is developing a novel, faster, quantitative test to diagnose COVID-19.
307	TRUE	TRUE	TRUE	TRUE	Task 415a: We are looking for blood and nasal swab samples from patients with COVID-19 to use as our positive control.
308	TRUE	TRUE	TRUE	TRUE	Task 415b: We need clinical data for patients who developed severe symptoms.
309	TRUE	TRUE	TRUE	TRUE	Intro to request 431: The objective of the project are: (I) to develop a deterministic dynamic model in order to simulate possible time-delay effects and their interpretations on variable incubation period, and (II) to develop a stochastic dynamic model to simulate and to forecast the regional peaks and the recovery period of the pandemic and to compare with time-dependent healthcare capacity thresholds. It is desired to gather with the other experts who are currently networked in related research directions. Informational support provided by the updated COVID clinical data is instrumental for this project.
310	TRUE	TRUE	TRUE	TRUE	Task 431a: We would like to know if there exists a network of epidemiologists currently active in COVID-19 battlefield, and if so, how to get connected to them.
311	TRUE	TRUE	TRUE	TRUE	Task 431b: We would like to know if it exists a reliable source of daily-updating COVID-19 statistics including 'clinical and epidemiological parameters'.
312	TRUE	TRUE	TRUE	TRUE	Intro to request 446: [PRIVATE COMPANY] Our team develops systems for remote diseases diagnostic using machine learning We had won a grant of the World Bank and we have developed a service for predicting lung diseases on the chest x-ray images using neural networks. Currently we are also developing a service to analyze lung and brain CT data and mammographies. We believe our service will hepl to diagnose COVID-19 in poor countries.
313	TRUE	TRUE	TRUE	TRUE	Task 446a: We need chest x-rays from people diagnosed with COVID-19.
314	TRUE	TRUE	TRUE	TRUE	Task 446b: We need CT datasets of people diagnosed with COVID-19
315	TRUE	TRUE	TRUE	TRUE	Task 400a: [PRIVATE COMPANY] We are working on developing recombinant alpaca antibodies to the spike one protein of the virus. We are looking for people who would be able to test our serum/antibodies out in a viral neutralization assay.
316	TRUE	TRUE	TRUE	TRUE	Task 428a: We are looking for a luciferase or fluorescent protein based reporter plasmid for SARS-Cov2 infection to be used on hACE2 stable cell lines to screen drugs for blocking COVID-19 (preferably SARS-Cov2 promoter driven reporter).
317	TRUE	TRUE	TRUE	TRUE	Intro to request 394: We have a potential drug that works as an endogenous ACE2 decoy with a 3-pronged advantage over other potential therapies, and needs help with some information.
318	TRUE	TRUE	TRUE	TRUE	Task 394a: We need expertise to know how best to deliver our compounds into the lungs/gut/systemic delivery (via inhaler, nebulizer or endobronchial delivery etc.). We will like to use an acid-degradable polymer to deliver our drug together with a peptide that binds to ACE2. A good suggestion/review of which chemistries (e.g. acetals, orthoester, hydrazones, imines, cis-aconityl etc.) could work best as an endosomal degradable linker will be very helpful.
319	TRUE	TRUE	TRUE	TRUE	Task 394b: There are several classes of drugs that are being repurposed to used against Covid-19 that are now in different phases of clinical trials. At least 28 could be found from clinicaltrials.gov We would need volunteers to compile a table with the main characteristics of each of these drugs.
320	TRUE	TRUE	TRUE	TRUE	Task 361a: One-page report about CNS complications of the COVID-19, (both reported through clinical or postmorten evaluations). References do not count to the page limit.
321	TRUE	TRUE	TRUE	TRUE	Intro to request 329: [PRIVATE COMPANY] I am developing an in-tube positive control reagent that can be used as an extraction and detection control in RT-qPCR diagnostic tests for COVID-19. I will need a couple of weeks to design and create this reagent, then a start-up manufacturer that I collaborate with can scale up production.
322	TRUE	TRUE	TRUE	TRUE	Task 329a: We need distributors who are makign RT-qPCR - based testing kits to get in touch if they need such a reagent to include in their dagnostic kits.
323	TRUE	TRUE	TRUE	TRUE	Task 329b: We also need public health labs who are carrying out testing to be informed in case they need this type of reagent.
324	TRUE	TRUE	TRUE	TRUE	Task 318a: This task requires assembling a dataset that has a daily history of new infections, deaths, and tests for each region and for each country. The format would follow the examples I have constructed manually for Netherlands and Spain. For each dataset, I would also need the source for the numbers so that I can verify them. Based on my preliminary research, the best place seems to be each country's CDC-equivalent. Wikipedia also has similar tables, but its quality needs to be checked.
325	TRUE	TRUE	TRUE	TRUE	Task 266a: [PRIVATE COMPANY] Risk assessment of working on Covid19 in BSL2 space. Based on literature relating to SARS and Influenza - literature compilation of how to inactivate/kill the virus while keeping RNA in tact for extraction and subsequent analysis in open areas.
326	TRUE	TRUE	TRUE	TRUE	Task 236a: I would need country/border lockdown dates and population density data from the countries that appears in this dataset: https://www.ecdc.europa.eu/en/publications-data/download-todays-data-geographic-distribution-covid-19-cases-worldwide
327	TRUE	TRUE	TRUE	TRUE	Task crf3a: [FOR CROWDFIGHT COVID-19 TEAM] We need volunteers who can help us at Crowdfight COVID-19. We need help both with general administrative duties that require no specific skills and with other tasks that do require scientific skills. If you are interested in joining our team, please state your availability and the kind of tasks you would be willing to perform (administrative/scientific/both), and please send you CV to crowdfightcovid19+recruit@gmail.com. Thank you very much!
328	TRUE	TRUE	TRUE	TRUE
329	TRUE	TRUE	TRUE	TRUE	20200401-1: Task [382a] Literature and in/vitro testing indicate that povidone iodine is virucidal against SARS-CoV-2 when used intra-nasally and intra-orally. This could prevent or reduce nosocomial virus acquisition, protecting the healthcare workforce and reducing in-hospital spread. (REF: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3563092). We wish to know if SARS-COV-2 infection is always initiated in the upper airways, and carried Â±systemic spread or is it initiated in lower airways. Our intervention would prevent acquisition in upper airways only, and so we are keen to know if this would substantially affect efficacy. Please state below if you already have the answer to this question, or if you would be willing to participate in a literature search to find it.
330	TRUE	TRUE	TRUE	TRUE	20200401-2: Task [348a] Epidemiological modellers to join our pro bon consultation team (at least 10 hr/week)
331	TRUE	TRUE	TRUE	TRUE	20200401-3: Task [348b] Epidemiological researchers to provide quality assurance of the information we display on site (10h/week)
332	TRUE	TRUE	TRUE	TRUE	20200401-4: Task [348c] UX designers (10h/week per volunteer)
333	TRUE	TRUE	TRUE	TRUE	20200401-5: Task [348d] Software developers (both backend and frontend)
334	TRUE	TRUE	TRUE	TRUE	20200401-6: Task [348e] People with policy experience to join our distribution team for handling incoming consultation requests
335	TRUE	TRUE	TRUE	TRUE	20200401-7: Task [262a] We need a Pseudo type of Covid-19 (i.e. an attenuated or transgenic virus such as the ones used in https://doi.org/10.1016/j.cell.2020.02.058 or doi:10.3791/59010) with high validity for investigation of S1:ACE2 inhibitors
336	TRUE	TRUE	TRUE	TRUE	20200401-8: Task [388a] We need someone who can generate purified, lyophilized Cas13d protein fused to fluorescent reporter protein. We need this protein to test a novel experimental treatment of COVID-19 in animals.
337	TRUE	TRUE	TRUE	TRUE	20200401-9: Task [412a] We are trying to develop a vaccine based on bacterial surface expression of CoV2 proteins; we need access to serum from recovered patients to test if our prototype is recognised by antibodies from convalescent patients. This is the first key step to move to test for protectivity
338	TRUE	TRUE	TRUE	TRUE	20200401-10: Task [368a] Scientists in Colombia are trying to donate the molecular biology reactive to support the diagnosis of COVID-19. We have some serious shortage of Reverse Transcriptase, as these are using all over the world for qPCR tests. I am writing to you to see if you know someone that has clones for reverse Trasncriptases and that is willing to donate them for production in Colombia.
339	TRUE	TRUE	TRUE	TRUE	20200401-11: Task [402a] A researcher is looking for country-wise data of infected/dead/recovered, disaggregated by sex. Do you know from where this data can be extracted (either for many countries or for one)?
340	TRUE	TRUE	TRUE	TRUE	20200401-12: Task [442a] If anyone has access to in vitro antiviral assays (or knows someone who does), we would be more than happy to discuss and contract this study
341	TRUE	TRUE	TRUE	TRUE	20200401-13: Task [442b] Does anyone have an active list of service providers that can execute in vitro antiviral SARS-CoV-2 or SARS-CoV studies? If not, would you know how to compile that list, and would you be willing to help to do it?
342	TRUE	TRUE	TRUE	TRUE	20200401-14: Task [426a] [PRIVATE COMPANY] We're working on an electroporation based vaccine platform. I'm hoping for someone to be able to recieve mouse sera and tell me if it's neutralizing virus or at least recognizing the spike protein.
343	TRUE	TRUE	TRUE	TRUE	20200401-15: Task [377a] [PRIVATE COMPANY] A german company is having trouble to find a provider of eSwabs. Anybody knows a German provider, or one that can ship to Germany?
344	TRUE	TRUE	TRUE	TRUE	20200401-16: Task [346a] [PRIVATE COMPANY] A pharmaceutical company has developed a gene therapy against COVID-19, but they don't have the means to manufacture it in scale. Do you know anyone who can help them manufacture it with regulatory compliance?
345	TRUE	TRUE	TRUE	TRUE
346	TRUE	TRUE	TRUE	TRUE	5: Request [217] We are looking at linear motifs in the ACE2 receptor cytoplasmic tail. We need to look into known ACE2 interactors from PPI (protein-protein interaction) studies (low or high throughput) and databases. The desired output would be a list of ACE2 interacting proteins with appropriate source references. The identification of PFAM domains within this list of proteins is also of high value to the project
347	TRUE	TRUE	TRUE	TRUE	6: Request [218] We are computationally interrogating the diversity of sequences and hoping to engineer antibody variants with neutralising activity. Could anyone share sequences of antibodies recognising SARS-CoV-2 (human immune repertoire data, VHH, scFV, mAb...)?
348	TRUE	TRUE	TRUE	TRUE	7: Request [219] [PRIVATE COMPANY] We want to perform a quick, in-vitro experiment to examine efficacy of a progenitor cell derived exosome product at reducing inflammatory cytokines (TNF alpha, GM CSF, IL-6) associated with Covid 19 cytokine storm. Can anyone suggest a cell line that will express these cytokines suitable for a proof of concept experiment?Information about the company: CellDrop is a University of Wyoming spinout that seeks to translate regenerative medicine techniques from the lab to the clinic. We specialize in controlling cell behavior through custom engineered biomaterials.
349	TRUE	TRUE	TRUE	TRUE	1: Request [224a]: We are looking for collaborators with strong expertise in analyzing RNA-seq data to elucidate the effects of chronic stress on factors associated with resilience or susceptibility to (and recovery from) COVID-19.
350	TRUE	TRUE	TRUE	TRUE	2: Request [224b]: We also have additional organs that can be analyzed via RNA-seq. Therefore, I would also appreciate working with labs that can run RNA-seq biological assays on samples that we have ready to go. (The core at our University that runs these assays is currently closed)
351	TRUE	TRUE	TRUE	TRUE	4: Request [226]: We are looking to adapt some protocols from other laboratories to do illumina paired end reads of SARS-CoV-2 obtained directly from cDNA from patient nasopharyngeal swabs. We have some great protocols and information but would love some help (from someone experienced in hybridization capture and NGS seq approaches) in vetting our protocol and making sure the parts are all sound. Integrated DNA technology will supply for free the library of probes to do hybridization-capture enrichment before sequencing. The viral nucleic acid will be a small minority of the original sample, and our nucleic acid purification kit uses carrier RNA.. so there are some small challenges that need to be overcome for us to succeed.
352	TRUE	TRUE	TRUE	TRUE	7: Request [232]: [PRIVATE COMPANY] List of all vaccines at queue now for treating Covid-19, and their composition (we at crowdfight COVID-19 would encourage selected volunteers to make this list public)
353	TRUE	TRUE	TRUE	TRUE	8: Request [234]: We want calculate the metamaterial resonance frequencies for COVIR-19, in order to find infrared frequencies that will inactivate the virus most effectively. We need access to Lumerica or some similar software such as COMSOL, ANSY-HFSS2.
354	TRUE	TRUE	TRUE	TRUE	10: Request [241b]: We seek collaborators or protocols for Rdrp activity assay. (we can ship our inhibitors to collaborator)
355	TRUE	TRUE	TRUE	TRUE	11: Request [241c]: We seek collaborators for in vivo testing of our inhibitors. (we can ship our inhibitors to collaborator)
356	TRUE	TRUE	TRUE	TRUE	12: Request [241d]: We seek ~5mg of active Nsp12 protein (or active protein complex) of SARS-CoV-2
357	TRUE	TRUE	TRUE	TRUE	13: Request [242a]: Request for reagent; does anyone have bacterial expression vectors and purification protocols available for Nsp13, Nsp14 and Nsp15 from SARS-COV2?
358	TRUE	TRUE	TRUE	TRUE	14: Request [242b]: Also about Nsp13, Nsp14 and Nsp15 from SARS-COV2: We also would be interested in evidence that the proteins might associate physically, and optimal conditions for stability of the complex.
359	TRUE	TRUE	TRUE	TRUE	15: Request [246]: I lead operations on a Health Crisis Communication Public Agency. To plan our strategy, we would like to learn more about crisis communication in other countries.
360	TRUE	TRUE	TRUE	TRUE	16: Request [248a]: Is there a benchmark dataset related to corona virus that I can use to test my model?
361	TRUE	TRUE	TRUE	TRUE	17: Request [248b]: Is there a drug designing group that I can collaborate with?
362	TRUE	TRUE	TRUE	TRUE	18: Request [248c]: Is there an experimental group that might be interested in working with us?
363	TRUE	TRUE	TRUE	TRUE	19: Request [249a]: I would need help to find protocols for sputum procesing and isolation of cells for FACs from Covid-infected patients
364	TRUE	TRUE	TRUE	TRUE	20: Request [249b]: I would need help to find protocols for procesing of biopsys to isolate cells for FACs from lungs of infected patients
365	TRUE	TRUE	TRUE	TRUE	21: Request [250]: A colleague and I have been gathering data concerning Africa's response to COVID-19 over time since the first case in the continent. We harvested several URLs to newspapers, news services, and other national and international media houses. Our goal is to map out the response against the expert counsel and offer recommendations going forward. However, the work of manually visiting each website it time-consuming. We are not experts in scraping information from multiple complex platforms. If there is an expert out there who can point us in the right direction to speed our work, it would be appreciated.
366	TRUE	TRUE	TRUE	TRUE
367	TRUE	TRUE	TRUE	TRUE	20200327-1: Task [222a] I work on drug discovery & development for infectious diseases, and I'm leading the effort against COVID-19 at my institution. I need a breeding pair of mice expressing the hACE2 to test compounds we have been screening in vitro in cell-based assays. I already ordered from JAX, but animals will be delivered only by the end of June. Can anyone provide them faster? (We can handle the shipping)
368	TRUE	TRUE	TRUE	TRUE	20200327-2: Task [240a] We are currently studying the host response of COVID-19 by collecting peripheral blood from COVID-19 patients. Some of our teams are performing experiments on PBMC, lymphocytes, monocytes, etc. We are urgently looking for someone with strong expertise in neutrophils. Do you have skills in isolating neutrophils or running functional assays on neutrophils? Does your lab have expertise in neutrophils? Do you have access to PC3 lab to process blood samples in your own institution? (Especially useful if you're based in Sydney, but we can also ship the samples) (No need to meet all the criteria--even getting advice from experts in neutrophils would be useful)
369	TRUE	TRUE	TRUE	TRUE	20200327-3: Task [250a] We have been gathering data concerning Africa's response to COVID-19 over time since the first case in the continent. We harvested several URLs to newspapers, news services, and other national and international media houses. Our goal is to map out the response against the expert counsel and offer recommendations going forward. However, the work of manually visiting each website it time-consuming. We are not experts in scraping information from multiple complex platforms. We would like to collaborate with someone who can automate part of this work for us.
370	TRUE	TRUE	TRUE	TRUE	20200327-4: Task [257a] We are trying to develop a more sensitive, rapid, and cost effective primary screening for COVID-19 using bioinformatics tools based on simple CBC (hematology, biochemistry and serology). To validate our tools we need 200 results of CBC+CRP from PCR positive+CT positive hospitalized patients as well as 200 results of CBC+CRP from healthy persons.
371	TRUE	TRUE	TRUE	TRUE	20200327-5: Task [259a] I have a project on the mechanisms that make the virus mutate. It is not so much about which mutations are selected for, but rather the mutagenesis process itself. I have found tentative differences between countries and the project is getting to an advanced stage now. It is based on the data from nextstrain.org and after preprocessing them, the analysis is written with R markdown. There are a few tasks ranging from quite simple ones, like grouping countries into meaningful units to more complicated genomics tasks. They are raised as "issues" in the associated (so far private) github repository. I would be happy to get more people involved to handle some of these tasks and would be happy to send an invite via Github, if somebody is interested to join.
372	TRUE	TRUE	TRUE	TRUE	20200327-6: Task [263a]We are trying to build a mathematical model to predict infected samples of COVID 19 using near infrared spectra (NIRS). Therefore, if there is anyone that have or could register NIRS spectra from both infected and non infected samples I could try to do these models. Perhaps a lab conducting PCR tests and with access to a NIRS device could register the spectra? We would need 50 samples of each (infected and non infected) to test if the model works.
373	TRUE	TRUE	TRUE	TRUE	20200327-7: Task [273a] We are part of a team which is designing a protocol to backtrack the routes of infected individuals and identify their contacts. As part of this project, we need to be able to distinguish between actual infected cases and those who just have coronavirus anxiety. We need a psychology expert to help us making a questionnaire that can help us make that distinction.
374	TRUE	TRUE	TRUE	TRUE	20200327-8: Task [274a] I am developing an assay to measure virus binding to ACE2. I have a strategy to develop a protein-protein interaction blocker that might prevent virus bindingto ACE2. This strategy depends on generating stapled alpha helices. Although I have experience in assay development and small molecule drug discovery, I have never made a stapled alpha helix and know little of the fied and current technology. I seek a collaborator who has previous successful experience in preparing stapled alpha helices, particularly wtih a goal of translating this to therapeutic use rather than solely for laboratory experimentation.
375	TRUE	TRUE	TRUE	TRUE	20200327-9: Task [278a] We have observed lower prevalence and lower severity of COVID-19 in our psychiatric patients than in the medical personnel. We hypothesize that the patients might be protected by some of the drugs they are taking, because previous research has linked psychotropic drugs to certain protection against viral infection, mainly antipischotic drugs such as phenotiacines, tricyclic antidepressants and some anticholinergic drugs such as benzptopin (Dyall et al. 2017). We would like to know about any other published results in this direction (antiviral effects of psychotropic drugs). Also, we would like to discuss the merit of this hypothesis with experts of all the involved disciplines (virologists, epidemiologists, infectious disease specialists, psychiatrists, pharmacologists, neurologists).
376	TRUE	TRUE	TRUE	TRUE	20200327-10: Task [301a] I am seeking advice on a protocol to ensure RNase free ethanol for a high throughput RNA extraction system suitable for RT PCR Covid testing.
377	TRUE	TRUE	TRUE	TRUE	20200328-1: Task [220a] My colleagues in South Africa have large quantities of pangolin scales from several muti markets in Southern Africa. This material (as well as swabs from the material) can be made available if a lab would have the capacity to study microbiomes/possible pathogens.
378	TRUE	TRUE	TRUE	TRUE	20200328-2: Task [241e] We need volunteers to do a literature search and summarise on the â€œproofreading mechanism of coronavirusâ€. Any research idea esp. on drug design is welcome too. Several reports (https://www.ncbi.nlm.nih.gov/pubmed/23966862; https://cen.acs.org/biological-chemistry/infectious-disease/Emory-discovered-antiviral-poised-COVID/98/i12; https://www.biorxiv.org/content/10.1101/2020.03.19.997890v1.full.pdf) suggested that CoV is so tricky that they could resist anti-viral nucleosides by carefully proofreading during RNA synthesis. We want to know more about the molecular mechanism of this proofreading mechanism ( likely via Exoribonuclease Activity of Rdrp). This can help us to design better drugs to flight COVID-19. We will invite the volunteers to be co-authors if their ideas / information turns out to be a viable project.
379	TRUE	TRUE	TRUE	TRUE	Intro to REQUEST [269] [PRIVATE COMPANY] EPFL-spin-off Swoxid developed photoactive and nanoporous ceramic filters that may be sterilized upon UV-lamp illumination multiple times. We propose a reusable antiviral mask that use our filter technology. With these filters, face masks could be reused up to 1000-times. Swoxid is now looking for partners to accelerate the industrial production efforts to combat the CoronaVirus outbreak and to end the threat of face mask shortages. We would need to test and certify a filter to be used in a 3D printed face mask for protection against COVID 19 (among other viruses).
380	TRUE	TRUE	TRUE	TRUE	20200328-3: Task [269a] We would need to know what are the options and protocols to test and certify the filter
381	TRUE	TRUE	TRUE	TRUE	20200328-4: Task [269b] We would like to contact companies or collaborators able to help with this testing and certification
382	TRUE	TRUE	TRUE	TRUE	20200328-5: Task [279a] If someone could share expression vectors for the Sars-cov-2 proteins that would be very much appreciated. We would like to have all of them for expression in human cells. If inside a gateway plasmid even better. We need the plasmids to prepare them for expression in human cells for interaction and drug development studies.
383	TRUE	TRUE	TRUE	TRUE	20200328-6: Task [281a] Looking for epidemiologists to investigate what looks like a correlation between the levels of sanitation of nations (in other words the quality of the tap water ...) and their susceptibility to the Covid-19 pandemic.
384	TRUE	TRUE	TRUE	TRUE	Intro to REQUEST [283] I want to test the hypothesis that the higher mortality in certain countries may have a genetic basis. I want to study if ACE2 protein express more in certain populations or there is any mutation in the coding region of the ACE2 genome of these population which makes binding virus to ACE2 easier. (We don't want to do genome sequencing, we only want to dig out the already published data to see if any SNP reported in these populations)
385	TRUE	TRUE	TRUE	TRUE	20200328-7: Task [283a] I need a bioinformatician who knows about genomics and proteomics.
386	TRUE	TRUE	TRUE	TRUE	20200328-8: Task [283b] I also need someone who knows molecular dynamics to perform binding simulation of the mutated ACE2 and the virus protein.
387	TRUE	TRUE	TRUE	TRUE	20200328-9: Task [302a] Our HDMA group of researchers are analyzing 16 metropolitan cities in Italy and 14 major cities in USA using Twitter Keywords. Then, analyze the socio economic patterns and trends to identify the cause and speed spread of the corona virus focusing on specific environment, social, and economic factors using visualization tools. We need raw information concerning the symptoms of the affected, information regarding gender, age, health conditions, and patients home city name and number of deaths by city.
388	TRUE	TRUE	TRUE	TRUE	20200328-10: Task [304a] I have blood samples from SARS-CoV-2-infected rhesus macaques. I need to run RNA-seq on them to look at host responses. Currently our staff is essential staff only, with no spare capacity on our sequencers. All work that can be done on site is limited to testing PPE for reuse and diagnostic testing. Right now we are looking for a collaborator to do library prep on total RNA and run the samples on a sequencer. Although we only need help with library prep and sequencing, we welcome the collaborator's participation in aligning and performing downstream analysis on these data as well if desired, although we do have the bioinformatics capability to do that.
389	TRUE	TRUE	TRUE	TRUE	20200328-11: Task [307a] We are looking for an immunology expert that can help us with literature search on immune cells subsets, cytokines and proliferation of T cells in the context of a viral infection/vaccination, to improve our interpretation of patterns we are seeing in COVID19 patients. Main focus should be human studies. We would like also to understand changes in these parameters (measured directly or indirectly, ie. gene expression) in any other species, but keeping in mind the differences with the human immune system. We would like to start with coronavirus and respiratory viruses if possible.
390	TRUE	TRUE	TRUE	TRUE	20200328-12: Task [313a] The Luxembourg Centre for Systems Biomedicine has initiated a large-scale community effort joined by Reactome, WikiPathways, CellDesigner, Pathway Commons and many other groups. More than 100 members are contributing, 40+ curators joined from 10+ countries and the number is growing (https://covid.pages.uni.lu/map_curation). The goal is to develop as quickly as possible a description of host-pathogen interaction mechanisms specific to the SARS-CoV-2 virus to support the fast-track development of efficient treatments. The task: we are hoping to involve clinicians and biologists knowledgable on the relevant mechanisms to help us building a high-quality trusted and practically-useful resource. We require advice on key papers, key pathways, recovery mechanisms from the top expert in the area.
391	TRUE	TRUE	TRUE	TRUE	20200328-13: Task [314a] We aim to build predictive models to predict ICU utilization, mortality and length of stay in hospitals. This will allow to optimize the allocation of critical hospital resources, such as ICU beds. We are looking for electronic records of individual COVID-19 patients about comorbidities, therapies, anagraphics, length of stay, discharge information and laboratory analyses. Anything in this direction at the individual patient level would immensely help.
392	TRUE	TRUE	TRUE	TRUE	20200328-14: Task [317a] [PRIVATE COMPANY] I need to know the complete qualitative composition of the old Upjohn product that was withdrawn years ago, called Albamycin Capsules. It contains 250mg novobiocin sodium but it also contains other inactive ingredients. I need to know those ingredients.
393	TRUE	TRUE	TRUE	TRUE	20200328-15: Task [320a] I have protein sequences related to COVID. I need to do phylogentic analysis. I have collected large number of sequences, but I cannot analyze them because I am in home without access to my workstation (I tried with my laptop, but it hanged). Can anybody help me with this? I can send the sequences.
394	TRUE	TRUE	TRUE	TRUE	Intro to REQUEST [324] Qiagen is a pharmaceutical company that has testing kits for COVID-19. Since they seem to be unable to keep up with the demand, we wonder if under these circumstances they could release their recipe for the viral RNA extraction kit.
395	TRUE	TRUE	TRUE	TRUE	20200328-16: Task [324a] Would it be feasible for a company to release part of their Intellectual Property like this?
396	TRUE	TRUE	TRUE	TRUE	20200328-17: Task [324b] Does anyone know of a contact inside Qiagen that could mediate such request?
397	TRUE	TRUE	TRUE	TRUE	20200328-18: Task [324c] Would this recipe be enough to enable production of kits in multiple institutions?
398	TRUE	TRUE	TRUE	TRUE	20200328-19: Task [324d] Are there available recipes already out there that we should be aware of and promoting/distributing?
399	TRUE	TRUE	TRUE	TRUE	20200328-20: Task [332a] I am trying to estimate the effect of different measures of social distancing by modeling their effect on the basic reproduction number R0 in epidemiological models, so we can make a more informed decision which measures to lift or keep in place in the future. I am looking for a list of all measures aiming to increase social distancing put in place in the 16 German states and the date when they became effective. Ideally coded as a table where each row is one specific measure (e.g. "all schools and daycare institutions close"), each column one of the 16 German states, and each cell contains the date when the measure became effective (if at all). I need volunteers who can harvest this information from public records.
400	TRUE	TRUE	TRUE	TRUE	20200328-21: Task [333a] We are currently setting up a drug screening on the spike/ACE2 interaction. We would need expression vectors for SARS-Cov-2 protein S or its Receptor binding domain and ACE2 expression vectors. Both protein should be ideally tagged either by His/GST tag or any other.
401	TRUE	TRUE	TRUE	TRUE	[378] We have generated in our lab respiratory transcriptome (RNAseq) from patients infected with SARS CoV-2 in order to compare patterns of response to the virus according to the severity of the disease. Does anyone know available softwares that enable to analyse modules related to immune responses (i.e. innate immunity including IFN-alpha pathway...adaptive immunity)
402	TRUE	TRUE	TRUE	TRUE	20200330-1: Task [387a] One page summary of Lopinavir/ritonavir trials and in-vitro data on COVID-19, with references at the end (refs don't count for the 1-page limit)
403	TRUE	TRUE	TRUE	TRUE	20200330-2: Task [387b] One page summary of Chloroquine, Hydroxychloroquine and Azithromycin on COVID-19 (refs don't count for the 1-page limit)
404	TRUE	TRUE	TRUE	TRUE	20200330-3: Task [387c] One page summary of Favipiravir on COVID-19 (refs don't count for the 1-page limit)
405	TRUE	TRUE	TRUE	TRUE	20200330-4: Task [387d] One page summary of Rapid Antigen detection Point of care tests for COVID-19 including Pros and Cons, lead manufacturers and their contacts, published evidence or unpublished results if any (refs don't count for the 1-page limit)
406	TRUE	TRUE	TRUE	TRUE	20200330-5: Task [390a] Virologist in Germany needs sera from recovered patients of COVID-19 for analysis. Are you aware of institutions that would be able to share (and ship) sera from recovered patients to Germany?
407	TRUE	TRUE	TRUE	TRUE	20200330-6: Task [393a] A researcher working with antibodies wants to collect and update the number of serology kits/test that are available to buy (gives this as a place to start: https://www.finddx.org/covid-19/pipeline/). Since this changes daily having the power of the crowds updating it would save a lot of time. Are you qualified and interested into creating and/or maintaining a list of serology kits?
408	TRUE	TRUE	TRUE	TRUE	20200330-7: Task [405a] I am developing a couple of live cell assay to determine tropism of Sars-CoV-2. Something I am looking for is to have isolates/viruses from other regions, namely, from Europe. Please contact me if you have genetically distinct isolates, or super antigenic isolates. I can test them, we have a BSL3 facility and all required equipment. Something else that can help is to have blood from infected donors as we will do extensive analysis in all the samples from our hospital.
409	TRUE	TRUE	TRUE	TRUE	20200330-8: Task [373a] We are looking for someone who is skilled in R package development to help us develop, debug, test edge cases, and write unit tests for the R packages that we are developing for ongoing COVID-19 analysis. Knowledge of mathematical modelling, statistics, or epidemiology is not essential. We are mostly struggling to simultaneously deal with updating doing analysis, debugging packages, and dealing with issues that people file (eg. a data source randomly changes their data around and breaks fetching functions). Someone who is happy working fairly independently would be ideal.
410	TRUE	TRUE	TRUE	TRUE	Task [403] The task is to use computational methods to find out, whether 1,7-dihydrodiimidazo[4,5-b:4',5'-e]pyridine (DIP) or its derivatives may be of any interest as potential anti-viral drugs.
411	TRUE	TRUE	TRUE	TRUE	20200330-9: Task [406a] We are searching for (potentially low-coverage) meta-transcriptome data of individuals with and without SARS-CoV-2. Given such data, we could test different sequence comparison methods to detect if a patient is infected with the virus or not (e.g. via common/specific k-mers, etc). In the best scenario we would be able to detect the virus with very low low amounts of sequencing reads. For now, we are unsure if and how this could be beneficial for medical purposes and if the quality and amount of obtained RNA is good enough to receive reasonable sequencing reads. We are looking for someone with such data and/or who could answer related questions
412	TRUE	TRUE	TRUE	TRUE	20200330-10: Task [327a] Create a list of anti-cancer compounds / kinase inhibitors (pyrazolopyrimidines). These compounds have similar structure to some antivirals currently used, and they can become targets for screening. The selected volunteers will screen the literature and will compile a table containing: (1) Their structure, (2) target (e.g. PI3K/mTOR pathway, tyrosin-receptors SCR, AXL), (3) potential antiviral properties, (4) effective dose 50 (EC50) (5) reference from where the data was extracted. As usual, please don't start this task before we assign it to you. However, if you already know papers that should be included in the search, please indicate them below. Thank you!
413	TRUE	TRUE	TRUE	TRUE	20200330-11: Task [380a] We are looking for someone with experience using Bayesian statistics for predictive analyses - we have data but require this individual to work with us on development and design of the analysis and with expertise in methodology to ensure work is appropriate/valid. They should be able to work independently but in close collaboration leading to co-authorship.
414	TRUE	TRUE	TRUE	TRUE	20200330-12: Task [380b] We are looking for someone with website expertise to help manage the webpage and resources available here https://globalsurg.org/covidsurg/
415	TRUE	TRUE	TRUE	TRUE	20200330-13: Task [411a] [PRIVATE COMPANY] We are developing a rapid test biosensor to detect COVD 19. We are in the development phase and need samples that are safe to test - specifically monoclonal IgG and IgM antibodies to test the sensor. Once we clear this stage we need to collaborate with researchers working with the virus samples to do a field test. Past this stage we can move towards clinical study. Please let us know how we could obtain the antibody samples, there are many companies announcing breakthroughs in this area but they are not commercially available yet as far as I know. It would be invaluable if anyone has leads or direct connections to developers of monoclonal antibodies.
416	TRUE	TRUE	TRUE	TRUE	20200330-14: Task [277a] We have synthesized various nucleoside analogues, which are mimics of ribavirin and other nucleoside antiviral drugs. We would like to know if someone can test them for antiviral activity against SARS-COV2.
417	TRUE	TRUE	TRUE	TRUE	20200330-15: Task [crf1a] [FOR CROWDFIGHT COVID-19 TEAM] We have little experience with massive mailings, and we are worried that anti-spam filters might start blocking us at some point. We are looking for someone who can advice us on "best practices" to avoid this.
418	TRUE	TRUE	TRUE	TRUE	20200330-16: Task [crf2a] [FOR CROWDFIGHT COVID-19 TEAM] Given the great variety of COVID-19-related funding sources, and their short deadlines, we would like to create a team to compile a general searchable database. The work would consist of looking for all national and international calls, and providing a summary of information for each one. If you volunteer for this task, please state your country below so that we can have a representation as wide as possible.
419	TRUE	TRUE	TRUE	TRUE	Task [445] We are searching for someone able to perform virtual screening of chimiotheks on the Prot S/ACE2 complex or protein/protein interfaces. We could test the selected compounds both in vitro and in cellular infection assay
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