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Active ingredients Study NameStudy TypObserved effectsStudy URL
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L-Theanine (L-γ-Glutamylethylamide)
A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study… AlphaWave® L-Theanine… (Evans et al., 2021)
Human study (randomized controlled trial)
Reduction of subjective stress markers and salivary cortisol in healthy adults under stress
https://pubmed.ncbi.nlm.nih.gov/34562208/
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L-Theanine (L-γ-Glutamylethylamide)
The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis (Bulman et al., 2025)
Human study (meta-analysis)
General improvement of certain sleep parameters (subjective quality, PSQI)
https://doi.org/10.1016/j.smrv.2025.102076
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Chamomile (Matricaria chamomilla L.)
A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract… in GAD (Amsterdam et al., 2009)
Human study (randomized controlled trial)
Significant reduction of anxiety symptoms in patients with mild to moderate generalized anxiety disorder
https://pubmed.ncbi.nlm.nih.gov/19593179/
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Chamomile (Matricaria chamomilla L.)
Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials (Kazemi et al., 2024)
Human study (meta-analysis)Improvement of sleep qualityhttps://pubmed.ncbi.nlm.nih.gov/39106912/
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Chamomile (Matricaria chamomilla L.)
Apigenin: a natural molecule at the intersection of sleep and aging
Literature reviewImproves sleep and slows aginghttps://pubmed.ncbi.nlm.nih.gov/38476603/
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Passionflower (Passiflora incarnata)
Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems (Harit et al.)
Human study (randomized controlled trial)
Significantly reduces stress and improves sleep qualityhttps://pubmed.ncbi.nlm.nih.gov/38646244/
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Passionflower (Passiflora incarnata)
Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients… (Movafegh et al., 2008)
Human study (randomized controlled trial)
Reduction of anxiety in outpatient surgery patientshttps://pubmed.ncbi.nlm.nih.gov/18499602/
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Passionflower (Passiflora incarnata)
A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata herbal tea on subjective sleep quality
Human study (randomized controlled trial)
Improvement of subjective sleep qualityhttps://pubmed.ncbi.nlm.nih.gov/21294203/
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Reishi (Ganoderma lucidum)
A randomized, double-blind, placebo-controlled study of a Ganoderma lucidum polysaccharide extract (Ganopoly®) in neurasthenia
Human study (randomized controlled trial)
Reduction of fatigue, improvement of well-being in patients with neurasthenia
https://pubmed.ncbi.nlm.nih.gov/15857210/
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Reishi (Ganoderma lucidum)
Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum… (Bandyopadhyay, 2024)
Human study (randomized controlled trial)
Improvement of psychological and physical parametershttps://pubmed.ncbi.nlm.nih.gov/39241163/
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Green anise (Pimpinella anisum L.)
Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial
Human study (randomized controlled trial)
Significant reduction in postprandial functional dyspepsia symptoms (heaviness, early satiety, epigastric discomfort after meals)
https://pubmed.ncbi.nlm.nih.gov/25767516/
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Green anise (Pimpinella anisum L.)
Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: A double-blind randomized clinical trial
Human study (randomized controlled trial)
Significant improvement in quality of life (8 SF-36 domains) in patients suffering from postprandial distress syndrome
https://pubmed.ncbi.nlm.nih.gov/25709650/
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