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"CLINICAL AND EPIDEMIOLOGY" pillar
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TASKSDELIVERABLESInstitutions to contribute
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1.1 Definition of APTCB research programme in clinical sciences D1: Report with proposed scientific research outline for clinically-oriented research fields - pre-clinical and clinical in radiation oncology, radiobiology and nuclear medicine (radiopharmaceuticals) – based on state-of-the-art and networking with relevant facilities. Report to include already active research groups in the relevant fields within the Baltic States.  Needs discussion about the future and existing research groups (RSU/UL), see Proposal p.10!NCI · The creation of outline for research programme of APTCB facility in clinical sciences for advanced cancer treatments modalities and basic science (radiobiology, radiopharmaceutical production etc.).
· Actual research proposals and grant applications related to the future research programme of the facility;
Interested in coordination of the task.
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LSMU
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RSU: active participation in the WP, involvement and cooperation with the University hospitals, clinical methodology centers, Healthcare Ministry and professional organizations.
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KTU: medical physics field
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1.2 Relevant medical statistics in the region D2: Conclusive report about current number of cancer patients, radiotherapy treatments and other relevant statistical parameters, as well as parameters relevant to assess capacity in nuclear medicine. Report is to provide also possible eligible fraction of cancer patients for particle therapy based on literature studies and also extrapolation of the trends over the coming 10-20 years. NCI · The collection of statistical information from existing cancer registries and additional data sources, if applicable (resources at national health institutions and ministry level);
· Considerations or implementation of additionally necessary aspects in the registries for the future (only existing sources to be used);
Interested in coordination of the task.
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LSMU
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RSU: active participation in the WP (social healthcare, Center for Disease Prevention and Control), involvement and cooperation with the University hospitals, clinical methodology centers, Healthcare Ministry and professional organizations.
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1.3 Patient eligibility criteria for proton therapy D3: Report describing the options, approaches and models for patient eligibility for particle therapy based on international experience. Report is to also provide overview of existing clinical evidence as basis for eligibility.  D3 and D4 should be combined! (RSU/UL)NCI · The creation of recommendations for eligibility criteria model and referral mechanisms;
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LSMU
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RSU/UL: active participation in reviewing international standards, guidelines (IAEA, EANM).
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KTU: medical physics field
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D4: Recommendations for most suitable patient selection and eligibility estimation methodology for the Baltic States.  D3 and D4 should be combined! (RSU/UL)NCI · The creation of recommendations for eligibility criteria model and referral mechanisms;
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LSMU
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1.4 Patient referral, connections with particle therapy community D5: Report on existing methods of referral in Baltic States for other cancer treatment methods (conventional radiotherapy, chemotherapy etc.), provision of comparison with other relevant countries having particle therapy facility. NCI · Actual implementation of eligibility criteria model and referral mechanisms;
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LSMU
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RSU: Latvian oncology methodology center, National Cancer Institute, etc.
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D6: Recommendations for most suitable patient referral methodology for Baltic States.  We can only provide recommendations. (RSU/UL)NCI · Actual implementation of eligibility criteria model and referral mechanisms;
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LSMU
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