VACCINE COST BENEFIT ANALYSIS TABLE v3.0

	A	B	C	D	E	F	G	H	I	J	K	L	M
1	CHILDHOOD VACCINE ANALYSIS - BENEFIT TABLE - RISK OF INFECTIOUS DISEASE
2	VACCINE	PATHOGEN	DOSES	INFECTION RATE (PRE-VAX)	INFECTION RATE (CURRENT)	MORTALITY RATE	CHECK	RISK RATE (PRE-VAX)	RISK RATE PER 100,000 (PRE-VAX)	RISK RATE (CURRENT)	RISK RATE PER 100,000 (CURRENT)	IMPROVEMENT RATIO (PRE-VAX INFECTION RATE / CURRENT INFECTION RATE)	SOURCE LINK
3	HEP-B	HEPATITIS B	3	0.000084	0.00001	0.000005	X	0.0000000004	0.000042	0.00%	0.000005	7.4	https://www.hhs.gov/hepatitis/learn-about-viral-hepatitis/data-and-trends/index.html
4	DTaP	DIPTHERIA	5	0.15	1.23E-08	0.1	X	0.015	1500	0.00%	0.000123	12213749	http://www.vaclib.org/sites/debate/Vaccines.html
5	DTaP	TETANUS	5	0.000004	0.0000001	0.132	X	0.000000528	0.0528	0.00%	0.00132	39	https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6012a1.htm
6	DTaP	PERTUSSIS	5	0.2	0.00057	0.00001	X	0.000002	0.2	0.00%	0.00057	349.9	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106618/#CIW529C12
7	HiB	HAEMOPHILUS INFLUENZAE TYPE B	4	0.00054	0.0000008	0.06	X	0.0000324	3.24	0.00%	0.0048	674	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100154/
8	IPV	POLIO	4	0.00008	0.00000128	0.05	X	0.000004	0.4	0.00%	0.0064	61.5	https://vaccines.procon.org/view.additional-resource.php?resourceID=005964
9	PCV	PNEUMOCOCCAL CONJUGATE	4	0.00091	0.00002	0.00925	X	0.0000084175	0.84175	0.00%	0.0185	44.5	https://www.cdc.gov/pneumococcal/surveillance.html
10	RV	ROTAVIRUS	3	0.00015	0.00012	0.00005	X	0.0000000075	0.00075	0.00%	0.0006	0.3	https://www.cdc.gov/rotavirus/surveillance.html
11	FLU	INFLUENZA	5	0.145	0.000148	0.001	X	0.000145	14.5	0.00%	0.0148	978.7	https://en.m.wikipedia.org/wiki/Human_mortality_from_H5N1
12	MMR	MEASLES	2	0.00245	0.00001	0.002	X	0.0000049	0.49	0.00%	0.002	244	https://physiciansforinformedconsent.org/measles/dis/
13	MMR	MUMPS	2	0.000936085	0.0000007	0.002	X	0.0000018722	0.1872169	0.00%	0.00014	1336.3	https://www.cdc.gov/mumps/outbreaks.html
14	MMR	RUBELLA	2	0.000251636	2.76E-08	0.0008	X	0.0000002013	0.0201309	0.00%	0.000002	9113.8	https://www.cdc.gov/vaccines/pubs/pinkbook/rubella.html
15	VAR	VARICELLA (CHICKENPOX)	2	0.015384615	1.04E-07	1.67E-05	X	0.0000002564	0.025641	0.00%	0	147318.3	https://www.cdc.gov/chickenpox/surveillance/monitoring-varicella.html
16	HPV	HUMAN PAPILLOMAVIRUS	1	0.0000405	0.0000405	0.172	X	0.000006966	0.6966	0.00%	0.6966	0	https://report.nih.gov/nihfactsheets/viewfactsheet.aspx?csid=76
17	MCV	MENINGOCOCCAL CONJUGATE	2	0.00001	0.0000012	0.06666667	X	0.0000006667	0.0666667	0.00%	0.008	7.3	https://www.cdc.gov/meningococcal/surveillance/index.html
18	MenB	MENINGOCOCCAL B	2	0.00001	6.13E-07	0.3	X	0.000003	0.3	0.00%	0.018405	15.3	https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mening-serogroup.html
19	HEP-A	HEPATITIS A	2	0.000111524	0.000005	0.003	X	0.0000003346	0.0334572	0.00%	0.0015	21.3	https://www.cdc.gov/vaccines/pubs/pinkbook/hepa.html
20
21			53	51.60%	0.09%	89.88%	0	1.50%	1521.1	0.00%	0.8	12,373,961

	A	B	C	D	E	F	G
1	ROTAVIRUS WEIGHTED AVERAGE SERIOUS ADVERSE RISK RATE
2
3	STRATA	TYPE	SAE per 100,000	SAE rate (UNWEIGHTED)	Sample Size	weight %	weighted rate
4	A	GENERAL SAE	3946	3.90%	18132	5.30%	0.21%
5	B	GENERAL SAE	3757	3.80%	79960	23.60%	0.88%
6	C	GENERAL SAE	4969	5.00%	209	0.10%	0.00%
7	D	GENERAL SAE	2889	2.90%	64742	19.10%	0.55%
8	E	GENERAL SAE	9995	10.00%	5964	1.80%	0.18%
9	A	GENERAL SAE	2377	2.40%	70512	20.80%	0.49%
10	B	GENERAL SAE	3152	3.20%	73246	21.60%	0.68%
11	D	GENERAL SAE	1431	1.40%	5336	1.60%	0.02%
12	E	GENERAL SAE	3654	3.70%	1494	0.40%	0.02%
13	D	GENERAL SAE	14018	14.00%	11651	3.40%	0.48%
14	D	GENERAL SAE	18939	18.90%	8210	2.40%	0.46%
15		INTUSSUSCEPTION	60	0.10%		0.00%	0.00%
16		INTUSSUSCEPTION	36	0.00%		0.00%	0.00%
17		INTUSSUSCEPTION	69	0.10%		0.00%	0.00%
18		INTUSSUSCEPTION	141	0.10%		0.00%	0.00%
19
20	AVERAGE		4628.866667	4.60%		0.00%	3.98%
21
22	https://www.who.int/vaccine_safety/initiative/tools/Rotavirus_vaccine_rates_information_sheet_0618.pdf
23
24
25	ROTAVIRUS WEIGHTED AVERAGE MORTALITY RISK RATE
26
27	STRATA	MORTALITY per 100,000	MORTALITY RATE (UNWEIGHTED)	Sample Size	weight %	weighted rate
28	A	140	0.14%	1474	0.40%	0.00%
29	B	170	0.17%	76551	22.60%	0.04%
30	D	170	0.17%	64742	19.10%	0.03%
31	E	2570	2.57%	5964	1.80%	0.05%
32	A	30	0.03%	18048	5.30%	0.00%
33	B	360	0.36%	3333	1.00%	0.00%
34	D	290	0.29%	700	0.20%	0.00%
35	E	1000	1.00%	202	0.10%	0.00%
36	A	70	0.07%	69387	20.50%	0.01%
37	B	70	0.07%	72978	21.60%	0.02%
38	D	1550	1.55%	5290	1.60%	0.02%
39	E	5800	5.80%	1308	0.40%	0.02%
40	D	1370	1.37%	4091	1.20%	0.02%
41	D	350	0.35%	7500	2.20%	0.01%
42	D	700	0.70%	6799	2.00%	0.01%
43
44	AVERAGE	976	0.00976		0	0.24%
45
46	https://www.who.int/vaccine_safety/publications/WHO_Rotavirus_vaccines_systematic_review_Cochrane.pdf

	A	B	C	D	E	F
1	HPV AVERAGE SERIOUS ADVERSE RISK RATE
2
3	TYPE	SAE per 100,000	SAE rate (UNWEIGHTED)	Sample Size	weight %	weighted rate
4	GENERAL SAE	858.2	0.86%	28671	24.41%	0.21%
5	GENERAL SAE	733.8	0.73%	3810	3.24%	0.02%
6	GENERAL SAE	1836.6	1.84%	14268	12.15%	0.22%
7	GENERAL SAE	11676.8	11.68%	30843	26.26%	3.07%
8	NEW ONSET CHRONIC DISEASE	1240.1	1.24%	9511	8.10%	0.10%
9	NEW ONSET CHRONIC DISEASE	4680.8	4.68%	30349	25.84%	1.21%
10	MULTIPLE SCLEROSIS	6.12	0.01%			0.01%
11	MULTIPLE SCLEROSIS	7.54	0.01%			0.01%
12
13	AVERAGE	2629.995	2.63%		100.00%	4.83%
14
15	https://www.who.int/vaccine_safety/initiative/tools/HPV_vaccine_rates_information_sheet_1217.pdf
16
17

	A	B	H	J
1	ANALYSIS TABLE - VACCINE RISK VS. CHILDHOOD DISEASE RISK
2
3	TOTAL AVERAGE EFFECTIVENESS RATIO OF CHILDHOOD VACCINES		12373961
4
5	TOTAL PRE-VACCINE MORTALITY RISK OF INFECTIOUS CHILDHOOD DISEASES		1.52%
6		PER 100,000 PEOPLE	1,521
7
8	TOTAL CURRENT MORTALITY RISK OF INFECTIOUS CHILDHOOD DISEASES		0.0008%
9		PER 100,000 PEOPLE	0.8
10
11	TOTAL ADVERSE REACTION REPORT RATE FOR CHILDHOOD VACCINES		11.30%
12	TOTAL ADVERSE REACTION REPORT RATE MINUS RV & HPV		2.30%
13
14	RISK RATIO OF VACCINES VS. CHILDHOOD DISEASE (PRE-VACCINE)		7.5
15	RISK RATIO OF VACCINES (MINUS RV & HPV) VS. CHILDHOOD DISEASE (PRE-VACCINE)		1.5
16	RISK RATIO OF VACCINES VS. CHILDHOOD DISEASE (CURRENT)		14660.3
17	RISK RATIO OF VACCINES (MINUS RV & HPV) VS. CHILDHOOD DISEASE (CURRENT)		2949.9
18
19	VAERS REPORTS PER YEAR		11,000	http://www.vaccinesafety.edu/VAERS-Braun.htm
20	REPORTING RATE FOR ADVERSE EVENTS		2.50%	http://www.vaccinesafety.edu/VAERS-Braun.htm
21	ESTIMATED ADVERSE EVENTS PER YEAR		440,000
22	CHILDREN BORN PER YEAR IN U.S. (2017)		3,853,472
23	ESTIMATED ADVERSE EVENT RATE		11.40%

	A	B	C	D	E	F
1	CHILDHOOD VACCINE ANALYSIS - COST TABLE - RISK OF SERIOUS ADVERSE EVENT
2	VACCINE	CONDITION	DOSES	INJURY RATE	RISK RATE	SOURCE LINK
3	HEP-B	ANAPHYLAXIS	3	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/Hep_B_Vaccine_rates_information_sheet.pdf
4	DTaP	ANAPHYLAXIS	5	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/DTP_vaccine_rates_information_sheet.pdf
5	DTaP	NEUROLOGICAL EVENTS	5	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/DTP_vaccine_rates_information_sheet.pdf
6	DTaP	HYPOTONIC-HYPORESPONSIVE	5	0.29%	1.46%	https://www.who.int/vaccine_safety/initiative/tools/DTP_vaccine_rates_information_sheet.pdf
7	DTaP	ENCEPHALOPATHY	5	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/DTP_vaccine_rates_information_sheet.pdf
8	DTaP	SEIZURES	5	0.06%	0.30%	https://www.who.int/vaccine_safety/initiative/tools/DTP_vaccine_rates_information_sheet.pdf
9	HiB	NONE REPORTED	4	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/HiB_Vaccine_rates_information_sheet.pdf
10	IPV	POLIO	4	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/polio_vaccine_rates_information_sheet.pdf
11	PCV	NONE REPORTED	4	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/Pneumococcal_Vaccine_rates_information_sheet.pdf
12	RV	DEATH	1	0.24%	0.24%	https://www.who.int/vaccine_safety/publications/WHO_Rotavirus_vaccines_systematic_review_Cochrane.pdf
13	RV	GENERAL SEVERE ADVERSE EVENT	1	3.98%	3.98%	https://www.who.int/vaccine_safety/initiative/tools/Rotavirus_vaccine_rates_information_sheet_0618.pdf
14	FLU	ANAPHYLAXIS	5	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/Influenza_Vaccine_rates_information_sheet.pdf
15	FLU	OCULO-RESPIRATORY SYNDROME	5	0.01%	0.04%	https://www.who.int/vaccine_safety/initiative/tools/Influenza_Vaccine_rates_information_sheet.pdf
16	FLU	GUILLAIN-BARRE	5	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/Influenza_Vaccine_rates_information_sheet.pdf
17	MMR	ANAPHYLAXIS	2	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/MMR_vaccine_rates_information_sheet.pdf
18	MMR	SEIZURES	2	0.09%	0.17%	https://www.who.int/vaccine_safety/initiative/tools/MMR_vaccine_rates_information_sheet.pdf
19	MMR	THROMBOCYTOPENIA	2	0.00%	0.01%	https://www.who.int/vaccine_safety/initiative/tools/MMR_vaccine_rates_information_sheet.pdf
20	MMR	ASEPTIC MENINGITIS	2	0.10%	0.20%	https://www.who.int/vaccine_safety/initiative/tools/MMR_vaccine_rates_information_sheet.pdf
21	VAR	SEIZURES	2	0.05%	0.10%	https://www.who.int/vaccine_safety/initiative/tools/Varicella_Zoster_Vaccine_rates_information_sheet.pdf
22	HPV	ANAPHYLAXIS	1	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/HPV_vaccine_rates_information_sheet_1217.pdf
23	HPV	GENERAL SEVERE ADVERSE EVENT	1	4.83%	4.83%	https://www.who.int/vaccine_safety/initiative/tools/HPV_vaccine_rates_information_sheet_1217.pdf
24	HPV	MULTIPLE SCLEROSIS	1	0.01%	0.01%	https://www.who.int/vaccine_safety/initiative/tools/HPV_vaccine_rates_information_sheet_1217.pdf
25	MCV	ANAPHYLAXIS	2	0.00%	0.00%	https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mening.html
26	MenB	ANAPHYLAXIS	2	0.00%	0.00%	https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mening-serogroup.html
27	HEP-A	NONE REPORTED	2	0.00%	0.00%	https://www.who.int/vaccine_safety/initiative/tools/Hep_A_Vaccine_rates_information_sheet.pdf
28
29		TOTAL	76	9.70%	11.30%
30
31		TOTAL MINUS HPV & RV			2.30%

	A	B	C	D	E	F	G	H
1	SUMMARY of COMPARATIVE RISK: VACCINES vs. PREVENTABLE DISEASES
2			PATHOGEN RISK RATES		VACCINE RISK RATES	COMPARATIVE RISK
3	VACCINE	PATHOGEN	MORTALITY + PERMANENT INJURY RISK from PATHOGEN (PRE-VACCINE)	MORTALITY + PERMANENT INJURY RISK from PATHOGEN (CURRENT)	MORTALITY + SEVERE ADVERSE EVENT RATE from VACCINE	RISK RATIO: PRE-VACCINE (VACCINE RISK / DISEASE RISK)	RISK RATIO: CURRENT (VACCINE RISK / DISEASE RISK)	THREAT RANKING (HIGH to LOW)
4	VAR	VARICELLA (CHICKENPOX)	0.00%	0.00%	0.10%	3,900.00	574,545,454.50	1
5	RV	ROTAVIRUS	0.00%	0.00%	3.98%	5,302,732.00	6,628,415.00	2
6	DTaP	DIPHTHERIA, TETANUS, PERTUSSIS	1.50%	0.00%	1.76%	1.2	873,646.00	3
7	FLU	INFLUENZA	0.01%	0.00%	4.21%	290.7	284,782.40	4
8	MMR	MEASLES, MUMPS, RUBELLA	0.00%	0.00%	0.38%	548.6	178,591.30	5
9	HEP-B	HEPATITIS B	0.00%	0.00%	0.00%	7,857.10	66,000.00	6
10	HPV	HUMAN PAPILLOMAVIRUS	0.00%	0.00%	4.83%	6,937.70	6,937.70	7
11	IPV	POLIO	0.00%	0.00%	0.00%	1.4	89.3	8
12	MCV	MENINGOCOCCAL CONJUGATE	0.00%	0.00%	0.00%	3	25	9
13	MenB	MENINGOCOCCAL B	0.00%	0.00%	0.00%	0.7	10.9	10
14	HEP-A	HEPATITIS A	0.00%	0.00%	0.00%	-	-	11
15	HiB	HAEMOPHILUS INFLUENZAE TYPE B	0.00%	0.00%	0.00%	-	-	12
16	PCV	PNEUMOCOCCAL CONJUGATE	0.00%	0.00%	0.00%	-	-	13