Genes regulating variation of protein N glycosylation in human populations

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148408-genes-regulating-variation-of-protein-n-glycosylation-in-human-populations

The use of enzymes in glycoengineering

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148407-the-use-of-enzymes-in-glycoengineering

Solid phase N glycan MALDI profiling workflows

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148406-solid-phase-n-glycan-maldi-profiling-workflows

Glycomic Diversity of Homogenous Cell Populations

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148405-glycomic-diversity-of-homogenous-cell-populations

A targeted approach to determining the human glycome

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148404-a-targeted-approach-to-determining-the-human-glycome

Glycomics of cancer and autoimmune diseases

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148403-glycomics-of-cancer-and-autoimmune-diseases

The Human Glycome Project

The 2nd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148402-the-human-glycome-project

Glycans as biomarkers and functional effectors of cardiometabolic diseases

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148401-glycans-as-biomarkers-and-functional-effectors-of-cardiometabolic-diseases

Detailed N and O-glycan analysis by MSn analysis

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148400-detailed-n-and-o-glycan-analysis-by-msn-analysis

Mass Spectrometry and Glycogenomics to Dissect the Human Skin Glycome

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148399-mass-spectrometry-and-glycogenomics-to-dissect-the-human-skin-glycome

Integrated glycomics and transcriptomics glycosphingolipids in cancer

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148398-integrated-glycomics-and-transcriptomics-glycosphingolipids-in-cancer

Immune responses against glycosylated biodevices

The 3rd Meeting of the Human Glycome Project

Vered Padler-Karavani

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148397-immune-responses-against-glycosylated-biodevices

The Human Brain N Glycome

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148396-the-human-brain-n-glycome

Glycan profiling and cardiometabolic risk

The 3rd Meeting of the Human Glycome Project

Clemens Wittenbecher

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148395-glycan-profiling-and-cardiometabolic-risk

Fragment-based sequencing methods for glycoconjugates

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148394-fragment-based-sequencing-methods-for-glycoconjugates

Proinflammatory IgG Antibodies - Functional Annotation

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148393-proinflammatory-igg-antibodies-functional-annotation

Glycosylation in cancer

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148392-glycosylation-in-cancer

Quantitative genetics of human protein N-glycosylation

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148391-quantitative-genetics-of-human-protein-n-glycosylation

Glycan biomarkers for cardiovascular events

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148390-glycan-biomarkers-for-cardiovascular-events

The Molecular Human

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148389-the-molecular-human

A Bitter Sweet Symphony at the frontiers of cancer, infection and inflammation

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148388-a-bitter-sweet-symphony-at-the-frontiers-of-cancer-infection-and-inflammation

Tumor Associated Carbohydrate Antigens (TACAs) in CRC

The 3rd Meeting of the Human Glycome Project

Guinevere Lageveen-Kammeijer

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148387-tumor-associated-carbohydrate-antigens-tacas-in-crc

Introduction to the 3rd Meeting of the Human Glycome Project

The 3rd Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148386-introduction-to-the-3rd-meeting-of-the-human-glycome-project

The role of glycosylation in IgG - Fc receptor interactions

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148385-the-role-of-glycosylation-in-igg-fc-receptor-interactions

How glycan switch can be a tool to treat a disease

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148384-how-glycan-switch-can-be-a-tool-to-treat-a-disease

On the role of Fc and variable domain glycans in B cell responses

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148383-on-the-role-of-fc-and-variable-domain-glycans-in-b-cell-responses

Impact of IgG4 glycosylation on immune pathology versus activity

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148382-impact-of-igg4-glycosylation-on-immune-pathology-versus-activity

Glycan biomarkers for future cardiovascular events in primary and secondary prevention

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148381-glycan-biomarkers-for-future-cardiovascular-events-in-primary-and-secondary-prevention

Thirteen Years of Genome-Wide Association Studies of Human ProteinN-Glycosylation

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148380-thirteen-years-of-genome-wide-association-studies-of-human-proteinn-glycosylation

Glycosylation in the Down syndrome

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148379-glycosylation-in-the-down-syndrome

Functional validation of a gene network that regulates IgG glycosylation

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148378-functional-validation-of-a-gene-network-that-regulates-igg-glycosylation

Genetic regulation of IgG and transferrin glycosylation

The 4th Meeting of the Human Glycome Project

Azra Frkatović Hodžić

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148377-genetic-regulation-of-igg-and-transferrin-glycosylation

Immunoglobulin G glycans in health and disease

The 4th Meeting of the Human Glycome Project

Marina Martinić Kavur

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148376-immunoglobulin-g-glycans-in-health-and-disease

Glycans in personalized medicine and cancer patient stratification

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148375-glycans-in-personalized-medicine-and-cancer-patient-stratification

Introduction to the the 4th Human Glycome Project Meeting

The 4th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148374-introduction-to-the-the-4th-human-glycome-project-meeting

Introduction to the 5th Human Glycome Project Meeting

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148373-introduction-to-the-5th-human-glycome-project-meeting

Human Glycome Atlas Project

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148372-human-glycome-atlas-project

Glycomic Marker of Fibrosis in Liver Disease

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148371-glycomic-marker-of-fibrosis-in-liver-disease

The GlycanAge Test of Biological Age

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148370-the-glycanage-test-of-biological-age

Changes in IgG glycosylationa predicts future Crohn’s disease onset

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148369-changes-in-igg-glycosylationa-predicts-future-crohn-s-disease-onset

Genetic control of populational variation of human protein N-glycosylation

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148368-genetic-control-of-populational-variation-of-human-protein-n-glycosylation

Genome wide association studies of individual plasma proteins

The 5th Meeting of the Human Glycome Project

Azra Frkatović Hodžić

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148367-genome-wide-association-studies-of-individual-plasma-proteins

Comparative human tissue N-glycomes in 16 organs and immune cell subtypes

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148366-comparative-human-tissue-n-glycomes-in-16-organs-and-immune-cell-subtypes

Accelerated glycome ageing in Down syndrome

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148365-accelerated-glycome-ageing-in-down-syndrome

Sweetening your antibodies: lessons from natural immune responses

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148364-sweetening-your-antibodies-lessons-from-natural-immune-responses

High throughput human glycan analysis at the single cell level

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148363-high-throughput-human-glycan-analysis-at-the-single-cell-level

Glycobiology of cancer

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148362-glycobiology-of-cancer

Cell Surface N-Glycoproteomics to Map the Colorectal Cancer Glycome

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148361-cell-surface-n-glycoproteomics-to-map-the-colorectal-cancer-glycome

Dynamic Strategies for Development of Host-Responsive Medical Devices

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148360-dynamic-strategies-for-development-of-host-responsive-medical-devices

GlyCoDA: Compositional data analysis for disease risk prediction using glycans

The 5th Meeting of the Human Glycome Project

Konstantinos Flevaris

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148359-glycoda-compositional-data-analysis-for-disease-risk-prediction-using-glycans

Mining the information contained in the IgG glycome

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148358-mining-the-information-contained-in-the-igg-glycome

Establishment of a new detection method for polysialic acid in biological samples

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148357-establishment-of-a-new-detection-method-for-polysialic-acid-in-biological-samples

Glycans in Schistosoma haematobium

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148356-glycans-in-schistosoma-haematobium

How can we change the IgG glycome composition

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148355-how-can-we-change-the-igg-glycome-composition

Exploration of AI model’s capabilities for producing insights from glycan biomarkers

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148354-exploration-of-ai-model-s-capabilities-for-producing-insights-from-glycan-biomarkers

Antigen-specific Fab profiling of autoantibody repertoires in RA

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148353-antigen-specific-fab-profiling-of-autoantibody-repertoires-in-ra

Role of ACPA glycosylation in rheumatoid arthritis

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148352-role-of-acpa-glycosylation-in-rheumatoid-arthritis

IgG glycome as a biomarker and effector of CVD risk

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148351-igg-glycome-as-a-biomarker-and-effector-of-cvd-risk

Mapping of the pathway that regulates IgG glycosylation

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148350-mapping-of-the-pathway-that-regulates-igg-glycosylation

GlycanSwitch as a key mechanism inthe loss of self-tolerance

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148349-glycanswitch-as-a-key-mechanism-inthe-loss-of-self-tolerance

Site-specific profiling of structure & function of IgM B cell receptor glycans

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148348-site-specific-profiling-of-structure-and-function-of-igm-b-cell-receptor-glycans

Diversification of IgG by VD glycans: a novel mechanism to regulate complement

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148347-diversification-of-igg-by-vd-glycans-a-novel-mechanism-to-regulate-complement

IgG N-glycosylation in immunological studies using mouse models

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148346-igg-n-glycosylation-in-immunological-studies-using-mouse-models

Analytical precision of IgG glycome profiling

The 5th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148345-analytical-precision-of-igg-glycome-profiling

Glycomedicine: Unraveling the paracentral dogma

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148344-glycomedicine-unraveling-the-paracentral-dogma

Serum N-glycosylation changes in vascular dementia

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148343-serum-n-glycosylation-changes-in-vascular-dementia

The N-glycome of normal and epileptic human brain

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148342-the-n-glycome-of-normal-and-epileptic-human-brain

Brain glycan library: a resource for neuroglycobiology researchers

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148341-brain-glycan-library-a-resource-for-neuroglycobiology-researchers

Harnessing glycomics for cardiovascular precision medicine

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148340-harnessing-glycomics-for-cardiovascular-precision-medicine

Glycosylation of autoantibodies in rheumatic diseases: is it all the same?

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148339-glycosylation-of-autoantibodies-in-rheumatic-diseases-is-it-all-the-samequestion

IgG glycosylation in rheumatoid arthritis

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148338-igg-glycosylation-in-rheumatoid-arthritis

Clinical associations in serum and insulin-specific IgG N-glycome in T1D

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148337-clinical-associations-in-serum-and-insulin-specific-igg-n-glycome-in-t1d

Breaking the rules: How phosphorylated N-glycans in the brain defy the canonical model

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148336-breaking-the-rules-how-phosphorylated-n-glycans-in-the-brain-defy-the-canonical-model

Localising rare N-glycan motifs on human plasma proteins: Sulfation

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148335-localising-rare-n-glycan-motifs-on-human-plasma-proteins-sulfation

Human influenca A virus receptor binding evolution

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148334-human-influenca-a-virus-receptor-binding-evolution

Glycosylation in oncogenic processes: novel insights and clinical relevance

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148333-glycosylation-in-oncogenic-processes-novel-insights-and-clinical-relevance

referenceCE: automated capillary electrophoresis-based glycan analysis

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148332-referencece-automated-capillary-electrophoresis-based-glycan-analysis

AI-supported serum N-glycome prediction of chemotherapy response in lung cancer

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148331-ai-supported-serum-n-glycome-prediction-of-chemotherapy-response-in-lung-cancer

Effects of fasting on the IgG glycome

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148330-effects-of-fasting-on-the-igg-glycome

Next-gen CRISPR/dCas9 platforms for mechanistic studies of antibody glycosylation

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148329-next-gen-crisprdashdcas9-platforms-for-mechanistic-studies-of-antibody-glycosylation

Genetic control of protein N-glycosylation in humans: insights from GWAS

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148328-genetic-control-of-protein-n-glycosylation-in-humans-insights-from-gwas

Towards an integrated analysis of disease glycomic signatures

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148327-towards-an-integrated-analysis-of-disease-glycomic-signatures

Glycosylation Pathways in Cancer via AI and Automated Glycan Analysis

The 6th Meeting of the Human Glycome Project

Biochemistry, Genetics and Molecular Biology

https://underline.io/lecture/148326-glycosylation-pathways-in-cancer-via-ai-and-automated-glycan-analysis

Large Language Models as Model Organisms of Language in the Human Brain

Language is one of the richest and most complex human cognitive capacities. Yet, we lack a model organism to study its underlying neural mechanisms: unlike other important cognitive capacities, such as vision or memory, language does not have a clear counterpart in non-human animals, leaving a gap in our ability to develop and test mechanistic hypotheses. In recent years, large language models (LLMs) have emerged as the closest computational analogs we have but how can we use them effectively as model organisms for language in the human brain? In this talk, I will discuss the promise and challenges of this approach. I will present our recent work on brain-tuning using naturalistic brain recordings to refine LLMs so that their internal representations and processing better align with human neural data. But beyond representational similarity, a key question remains: do LLMs rely on mechanisms that are similar to those in the brain? And at what level of abstraction should we assess this similarity? This research direction aims to transform LLMs from mere engineering artifacts into powerful scientific tools for uncovering how the brain supports our most distinctive cognitive ability.

EACL 2026 Main Conference

EACL Keynotes and Invited Talks

https://underline.io/lecture/148322-large-language-models-as-model-organisms-of-language-in-the-human-brain

Search with Complex Topics and Learned Sparse Retrieval

Today, search is used by LLMs to support retrieval-augmented generation as well as by humans. In this new setting, how does what we want from a search engine change, and what are promising approaches to take? I will describe work on two themes related to these questions: (1) retrieving documents to support complex information needs in the context of long-form retrieval-augmented generation and (2) exploring learned sparse retrieval as a promising paradigm for first-stage retrieval. In the former line of work, I will discuss search systems aimed at maximizing coverage of relevant information and approaches for evaluating their ability to do so independent of a generation system. In the latter line of work, I will describe research positioning learned sparse retrieval as a compelling alternative to dense retrieval.

EACL 2026 Main Conference

EACL Keynotes and Invited Talks

https://underline.io/lecture/148321-search-with-complex-topics-and-learned-sparse-retrieval

Omnilinguality, Scaling AI to Any language

Communication across languages has been historically a "holy grail" in the context of AI. In a world with more than 7000 languages, AI still falls short in terms of coverage or equitably serving different languages. For decades we have focused on high-resource languages, since models have largely been resource-dependent. Today we are witnessing the evolution of techniques that can contribute to better represent a larger number of languages. We are kind of breaking the “digital desert”. In this talk, we will cover an overview of the path towards Omnilinguality in AI through the lens of the Machine Translation, starting with basic but complex definitions such as language or long-tail. MT is one of the most popular and well-explored applications in multilinguality. MT has been shown to scale to a massive number of languages with flagship specialised models covering from hundreds up to thousands of languages. Progress in MT has been largely driven by the scientific community effort of WMT that has put together competitions, benchmarks and constantly posing new challenges. Other key contributions have been the open-sourced evaluation datasets such as FLORES that cover hundreds of languages in the Wikipedia domain, and more recently BOUQuET that builds on top of non-English data, originally created and expanding to more domains. These initiatives are complemented with open-initiatives that allow the community to contribute with more languages. In my personal opinion, while MT has served as a platform to reach such progress, it may not always be the main one. Even if we have not yet solved this task, the rise of LLMs shows the opportunity to solve many tasks at once. MT will still be a relevant part of the puzzle by being a source of synthetic data generation and a representative evaluation in breadth. However, I will argue that Omniliguality should not be faced task-specifically anymore and it should be taken as a great arena to test more broadly advanced LLMs techniques and an opportunity to come up with new methods to massively scale general purpose evaluation.

EACL 2026 Main Conference

Marta Ruiz Costa-jussà

EACL Keynotes and Invited Talks

https://underline.io/lecture/148317-omnilinguality-scaling-ai-to-any-language

Arabic and Technology: A 40-Year Perspective

Over the past four decades, work at the intersection of Arabic and technology has evolved alongside major technical breakthroughs and shifting regional and global political dynamics. In this talk, I revisit the development of Arabic NLP and AI, from early foundational efforts to today’s large-scale generative systems, and highlight how each phase has engaged with distinct aspects of Arabic’s linguistic complexity. I reflect on the language’s ambiguous orthography, rich morphology, diglossic landscape, and wide geographic and historical reach, and on the growing research community committed to ensuring that AI technologies meaningfully support Arabic and its diverse cultural expressions. I conclude with a forward-looking vision for building a cohesive and sustainable ecosystem that advances Arabic in AI through strengthened training, deeper collaboration, and sustained innovation for the next generation of researchers and practitioners.

EACL 2026 Main Conference

EACL Keynotes and Invited Talks

https://underline.io/lecture/148316-arabic-and-technology-a-40-year-perspective

Presidential Panel on the Future of AI Research

Over the past few years, Artificial Intelligence has bounded into the mainstream of society. Remarkable technical achievements in the use of Deep Learning and Large Language Models have given rise to expectations and hype regarding the possibility of achieving artificial general intelligence, as well as general concerns over the potential deleterious consequences of emerging AI technologies and how to ensure their responsible use. In this panel we engage four Past AAAI Presidents to discuss their views on questions relating to the current state and future of AI research, including such topics as important emerging application areas, current technical challenges, the eventual prospects for achieving artificial general intelligence, and potential AI risks and solutions.

Stephen Smith, Raj Reddy, Eric Horvitz, Manuela Veloso, Bart Selman

https://underline.io/lecture/146033-presidential-panel-on-the-future-of-ai-research

The Essence of Intelligence is Appropriate Action (not thinking, reasoning, learning or language) and other things every student of AI should know

An agent acts in its world to achieve its objectives. Intelligence allows the agent to make decisions and act. In natural domains, sensing is limited, so acting is gambling. It’s a myth that passive learning and more data are all we need. An agent cannot learn from observations alone. It needs a real body to carry out experiments in its world, testing hypotheses, to determine causation, refining its model of the world’s dynamics. The agent is acting as a scientist: refining its model through experiments and acting appropriately to achieve its objectives. Its objectives depend on its preferences and values, and those of other agents its actions impact. Determining which values to use, and how preferences can be acquired fairly, is a major non-technical challenge. We address three primary questions: What should an agent believe? What should an agent do, given its beliefs, preferences, and abilities? What should the preferences of an agent be? Integrating these issues motivates the design of our latest AI textbook, Artificial Intelligence: Foundations of Computational Agents, (3rd Ed. 2023).

Alan Mackworth is a Professor Emeritus of Computer Science at the University of British Columbia. He works on artificial intelligence with applications in constraint satisfaction, cognitive robotics, assistive technology, hybrid systems and constraint-based agents. He invented the world’s first soccer-playing robots. He has co-authored two books: Computational Intelligence: A Logical Approach (1998) and Artificial Intelligence: Foundations of Computational Agents (2023, 3rd Ed.). Alan co-founded the UBC Cognitive Systems Program, the Centre for AI, Decision-making and Action (CAIDA) and the AI network of BC (AInBC). He has served as President of AAAI, IJCAI and CAIAC. He is a Fellow of AAAI, CAIAC, AGE-WELL, CIFAR and the Royal Society of Canada.

David Poole is a Professor Emeritus of Computer Science at the University of British Columbia. He is known for his work on combining logic and probability, probabilistic inference, relational probabilistic models, statistical relational AI and semantic science. He is a co-author of two AI textbooks (Cambridge University Press, 3rd edition 2023, and Oxford University Press, 1998), and co-author of ” Statistical Relational Artificial Intelligence: Logic, Probability, and Computation”. He is a former chair of the Association for Uncertainty in Artificial Intelligence, the winner of the Canadian AI Association (CAIAC) 2013 Lifetime Achievement Award, and is a Fellow of the Association for the Advancement Artificial Intelligence (AAAI) and CAIAC.

AAAI 2026 Invited Talks

Patrick Henry Winston Outstanding Educator Award

https://underline.io/lecture/146031-the-essence-of-intelligence-is-appropriate-action-not-thinking-reasoning-learning-or-language-and-other-things-every-student-of-ai-should-know

Small Data: A New Paradigm for the Next Generation of AI

AAAI 2026 Invited Talks

https://underline.io/lecture/146029-small-data-a-new-paradigm-for-the-next-generation-of-ai

AI for Reskilling, Upskilling, and Workforce Development

As AI becomes increasingly powerful and ubiquitous, it is disrupting skills and displacing workers. NSF’s National AI Institute for Adult Learning and Online Education (AI-ALOE) posits that AI can be part of the solution to the growing problem if we can use AI for reskilling, upskilling, and workforce development at scale. The long-term vision of AI-ALOE is to develop and use AI technologies to enhance the proficiency of online education for all adult learners, using in-person education as a benchmark. The day-to-day mission of AI-ALOE is to conduct responsible research into AI that is grounded in theories of human cognition and learning and derived from the scientific process of learning engineering. I will describe ongoing research at AI-ALOE.

AAAI 2026 Invited Talks

Robert S. Engelmore Memorial Lecture Award

https://underline.io/lecture/146028-robert-s-engelmore-memorial-lecture-award-ai-for-reskilling-upskilling-and-workforce-development

Professor Edward Feigenbaum: a Tribute to and Lecture by a Pioneer of AI on his 90th Birthday

Raj Reddy, Eric Horvitz, Bart Selman, Edward Feigenbaum, Yolanda Gil, Peter Friedland

AAAI 2026 Invited Talks

https://underline.io/lecture/146026-professor-edward-feigenbaum-a-tribute-to-and-lecture-by-a-pioneer-of-ai-on-his-90th-birthday

Navigating the AI Horizon: Promises, Perils, and the Power of Collaboration

We stand at the dawn of the AI era, a technological revolution poised to be the most consequential of our generation, presenting both unprecedented opportunities and profound challenges. But this promise is shadowed by significant challenges. To build a future we want, we must move beyond the hype and the headlines to confront the most pressing open problems—technical, sociotechnical, and multidisciplinary. This talk will review the rapid progress, dissect challenges ahead, and argue that our greatest task isn’t simply building smarter machines, but fostering the human wisdom to guide them towards a future that is not only intelligent but also equitable, safe, and profoundly human.

AAAI 2026 Invited Talks

https://underline.io/lecture/146024-navigating-the-ai-horizon-promises-perils-and-the-power-of-collaboration

AI and Program Reviewing Panel

Odest Chadwicke Jenkins, Kevin Leyton-Brown, Joydeep Biswas, Matthew E. Taylor

https://underline.io/lecture/146023-ai-and-program-reviewing-panel

Towards Embodied Agents that See, Simulate, and Reason

Large language models have revolutionized textual reasoning, yet their ability to act meaningfully in multimodal, real-world environments remains limited. They struggle to ground their decisions in visual context, adapt to changing goals, and plan actions over time—shortcomings that stem from a lack of structured, goal-driven reasoning and insufficient representations of the physical world.

In this talk, I present a unified framework for building embodied agents that can see, simulate, and reason. I begin by introducing methods for learning world simulators from data, arguing that visual reasoning—like textual reasoning—benefits from step-by-step processing. Inverting a physics simulator becomes key: agents must infer structured 3D neural representations of objects, parts, motions, and scenes directly from raw video. I describe methods for extracting such representations using generative priors, injecting them into vision-language models (VLMs), and scaling up their supervision via generative 3D simulation and fast, modular physics engines. These simulators enable agents to anchor their predictions in grounded physical reality, reducing hallucinations and improving control.

Complementing this simulation capability, I explore techniques that enable agents to reason over time and adapt their behavior. By integrating structured memory systems, agents learn to retain and retrieve relevant experiences to inform long-horizon plans. Language-based reflective feedback allows them to refine their strategies beyond what sparse rewards offer, forming abstractions that generalize across tasks. When trained to ground their reasoning directly in the visual environment, agents gain the ability to set subgoals, explore effectively, and verify their own hypotheses.

Together, these advances point toward autonomous systems that simulate before they act, reflect after they fail, and maintain an ongoing awareness of goals, constraints, and context. I will illustrate these capabilities across web automation, robotics, and interactive assistance, showing how agents that see, simulate, and reason offer a promising path toward general-purpose embodied intelligence.

AAAI 2026 Invited Talks

https://underline.io/lecture/146019-towards-embodied-agents-that-see-simulate-and-reason

From Workflows to Water Coolers: AI That Can Navigate Human Nature

AAAI 2026 Invited Talks

https://underline.io/lecture/146018-from-workflows-to-water-coolers-ai-that-can-navigate-human-nature

Fundamental physics and science communication

Physicists aim to explain the Universe in terms of a compact, interpretable set of principles. Deducing those principles from experiments poses many challenging and problems which are ripe for application of AI and present opportunities to develop new AI techniques. I will describe how AI has changed the way particle physicists work and speculate about the role of AI in the future of fundamental physics. Finally, I will describe my experience in science communication, as an author, podcaster and television producer.

AAAI 2026 Invited Talks

https://underline.io/lecture/146016-fundamental-physics-and-science-communication

Quest of AI towards Specializable Generalist: From Reasoning to Scientific Discovery

The pursuit of high-efficiency Artificial General Intelligence (AGI) requires more than brute-force scaling of model size and data. While scaling remains a key driver of capability, equally important are scalable architectural and principles—designs that continue to work, improve, and remain controllable as we vary model scale, domains, and modalities. Central to our approach is the concept of the “Specialized Generalist” – a pathway that achieves deep expertise across multiple domains without sacrificing broad generalization capabilities. In this talk, we introduce the “Specialized Generalist” paradigm and our implementation of it, SAGE (Synergistic Architecture for Generalized Expertise), a three-layer architecture designed to balance specialization and generalization in a systematic way. We will describe how SAGE’s Base Model, Synergy Fusion, and Exploration-Evolution layers interact in practice, focusing on concrete mechanisms for coordinating domain-specific expertise with broad general reasoning. We will share empirical results and recent advances in large reasoning models, embodied AI, and scientific applications to further illustrate the approach. A central motivation is to support “AGI for Science” by building a stable plateau of capabilities that can reliably assist with complex scientific workflows rather than isolated demos. Finally, we will outline the safety and governance questions that arise when deploying Specialized Generalist systems in high-impact settings, and discuss what we have learned so far about monitoring, alignment, and operational safeguards.

AAAI 2026 Invited Talks

https://underline.io/lecture/146014-quest-of-ai-towards-specializable-generalist-from-reasoning-to-scientific-discovery

From How to learn to What to learn in Multiagent Systems and Robotics

There has been a lot of exciting recent progress on new and powerful machine learning algorithms and architectures: how to learn. But for autonomous agents acting in the dynamic, uncertain world, it is at least as important to be able to identify which concepts and subproblems to focus on: what to learn.
This talk presents methods for identifying what to learn within the framework of reinforcement learning, focusing especially on applications in multiagent systems and robotics.

AAAI 2026 Invited Talks

https://underline.io/lecture/146013-from-how-to-learn-to-what-to-learn-in-multiagent-systems-and-robotics