HEK293_MuSIC_subsystems.xlsx

	A	B	C	D	E	F
1	System	Category	Predicted diameter (nm)	95% prediction interval (nm)	Number of proteins	Proteins
2	Subgroup of metabolic organelles	Known system	1572	[844, 2928]	41	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, MRPS31, MRPS9, RPL6, RPS13, HNRNPC, RBBP6, NOC2L, RPL28, RPL11, IMMT, AGK, MCAT, METTL17, MRPS11, NAT8L, NDUFA1, NDUFA10, NDUFA7, NDUFA9, NDUFAF2, NMNAT3, POLRMT, SUCLA2, TIMM50, TMLHE, TOMM40, URB2, YARS2
3	Ion transmembrane transport system	Putative system	1664	[893, 3100]	18	ANKRD46, CHST10, CLPTM1, DGCR2, DISP1, DNAJC18, FAM69B, FZD8, GABRA5, KCNB2, KCNQ2, MCOLN2, MCOLN3, MFSD10, PDE3B, POMT1, SLC41A3, XKR8
4	Transmembrane transport systems	Putative system	3769	[2023, 7021]	33	ACVR1, AGPAT4, C15orf61, CACNA2D2, GPR180, IGFBP2, IMMT, LMF2, NAT14, PCDH19, PEX10, SH3GL2, SLC35F2, TESC, TMEM177, ANKRD46, CHST10, CLPTM1, DGCR2, DISP1, DNAJC18, FAM69B, FZD8, GABRA5, KCNB2, KCNQ2, MCOLN2, MCOLN3, MFSD10, PDE3B, POMT1, SLC41A3, XKR8
5	RNA processing complex 2	Putative system	169	[90, 314]	6	RPL13A, DHX15, SNRNP70, RNPC3, NAA38, RPL7L1
6	RNA processing complex family	Known system	479	[257, 892]	32	RPL13A, KRI1, CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, RPS3A, ZNF45, SRRM1, U2AF2, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, CD2BP2, GEMIN4, SAFB2, HNRNPC, RBBP6, RRS1, RPL7L1, COIL, SF3A2, PRKRIP1
7	Nuclear splicing speckle	Putative system	1209	[649, 2252]	42	RPL13A, KRI1, CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, CD2BP2, GEMIN4, SAFB2, HNRNPC, SFMBT2, AKAP17A, RBBP6, ZRANB2, RRS1, NOC2L, RPL7L1, COIL, SF3A2, PRKRIP1, CASC3, HIRIP3, NOP56, NOS1AP, PRPF31
8	Ribosomal complex 4	Putative system	88	[47, 164]	6	RPL13A, RPL7A, DHX15, RPS3A, RPS13, PRR3
9	Ribosome	Known system	160	[86, 299]	27	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, DHX15, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, MRPS31, MRPS9, RPL6, RPS13, RRS1, NOC2L, NVL, REXO4, RPL7L1, RPL28, RPL11, PRR3, LIN28B
10	RNA splicing complex family	Known system	355	[191, 662]	27	CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, RPS3A, SRRM1, U2AF2, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, CD2BP2, GEMIN4, SAFB2, HNRNPC, RRS1, COIL, SF3A2, PRKRIP1
11	Chromatin regulation assembly	Putative system	785	[421, 1462]	14	HNRNPU, TAF6L, CHEK1, CTR9, EAF1, GTF2B, HIRA, HUS1B, NCAPD3, ORC3, RIF1, SFPQ, SUZ12, XRCC6
12	Nucleoplasm 2	Putative system	882	[473, 1643]	20	HNRNPU, HNRNPC, TAF6L, DAXX, ORC2, POLD1, SMARCAL1, TRIM28, CHEK1, CTR9, EAF1, GTF2B, HIRA, HUS1B, NCAPD3, ORC3, RIF1, SFPQ, SUZ12, XRCC6
13	Large ribosomal subunit subcomplex 2	Putative system	6	[3, 12]	5	RPL19, RPL27A, MRPL19, RPL38, RPL11
14	Ribosomal subunit	Known system	96	[52, 179]	20	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, MRPS31, MRPS9, RPL6, RPS13, NOC2L, RPL28, RPL11
15	Nucleoplasm 1	Known system	763	[409, 1421]	19	ING4, JAZF1, DMAP1, ING3, MORF4L1, RUVBL2, MYC, SRRM1, HNRNPU, INO80C, SIN3B, TAF5L, FAM120C, SATB1, EHMT2, TAF11, DR1, SULT1C4, TAF6L
16	RNA splicing complex 2	Putative system	46	[25, 86]	6	CCDC12, SNRNP70, SRRM1, RNPC3, SNRPA1, SF3A2
17	RNA splicing via transesterification reactions	Known system	172	[92, 320]	20	CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, SRRM1, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, SRRM2, SRSF10, CD2BP2, GEMIN4, HNRNPC, COIL, SF3A2
18	Ribosomal complex 2	Putative system	10	[5, 18]	4	RPL13A, RPL18, RPS3A, NOC2L
19	Polysomal ribosome complex	Putative system	58	[31, 109]	4	RPL19, RPS13, RPL7L1, LIN28B
20	Ribosome biogenesis subcomplex	Putative system	109	[59, 204]	8	RPL13A, RPL27A, KRI1, NVL, RPL7L1, DHX37, NOL12, ZNF771
21	Pre-rRNA processing assembly (PRRPA)	Putative system	81	[43, 151]	7	RPL13A, KRI1, RPS13, NOC2L, NVL, REXO4, RPL7L1
22	Ribosome biogenesis assembly	Known system	123	[66, 229]	21	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, MRPL19, RPL18, RPS3A, MRPS9, RPL6, RPS13, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, LIN28B
23	Spliceosomal complex family	Known system	264	[142, 492]	15	SNRPB2, SNRPC, SRRM1, U2AF2, DHX8, CDC40, HNRNPU, RNPS1, SRRM2, SRSF10, SAFB2, HNRNPC, AKAP17A, RBBP6, ZRANB2
24	Chromosome organization complex family	Putative system	583	[313, 1085]	15	ING4, JAZF1, DMAP1, ING3, MORF4L1, RUVBL2, MYC, SRRM1, INO80C, SIN3B, TAF5L, FAM120C, SATB1, EHMT2, TAF11
25	Negative regulation of RNA biosynthetic process	Putative system	668	[359, 1244]	8	SIN3B, FAM120C, BCORL1, CASP8AP2, E2F3, EHMT2, SFMBT2, ZNF296
26	Nuclear transcriptional speckle	Putative system	1270	[682, 2366]	14	JAZF1, MORF4L1, SIN3B, FAM120C, BCL11A, FBRSL1, NASP, SHPRH, BCORL1, CASP8AP2, E2F3, EHMT2, SFMBT2, ZNF296
27	Chromatin regulation complex	Putative system	211	[113, 393]	6	JAZF1, DMAP1, MORF4L1, SRRM1, FAM120C, SATB1
28	Chromatin organization complex family	Known system	279	[150, 520]	13	ING4, JAZF1, DMAP1, ING3, MORF4L1, RUVBL2, MYC, SRRM1, INO80C, SIN3B, TAF5L, FAM120C, SATB1
29	Catalytic step 2 spliceosome	Known system	59	[31, 109]	5	SNRPB2, SRRM1, DHX8, CDC40, HNRNPC
30	Subgroup of spliceosomal complex family	Known system	158	[85, 295]	12	SNRPB2, SNRPC, SRRM1, U2AF2, DHX8, CDC40, HNRNPU, RNPS1, SRRM2, SRSF10, SAFB2, HNRNPC
31	Small nuclear ribonucleoprotein complex family	Known system	72	[39, 134]	11	CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, SRRM1, CDC40, SNRPA1, CD2BP2, GEMIN4
32	Ribosomal complex 1	Putative system	9	[5, 17]	4	RPL19, RPL27A, RPL18, RPS13
33	Ribosomal complex 3	Putative system	12	[6, 22]	4	RPL13A, RPL18, MRPS9, RPS13
34	Cotranslational protein targeting to membrane system	Known system	16	[9, 30]	11	RPS18, RPL13A, RPL19, RPL27A, RPL7A, MRPL19, RPL18, RPS3A, MRPS9, RPL6, RPS13
35	Pre-catalytic spliceosome	Known system	48	[26, 90]	9	CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, SRRM1, CDC40, SNRPA1
36	Splicing regulatory complex	Putative system	54	[29, 100]	4	U2AF2, RNPS1, SRRM2, SRSF10
37	U2-type spliceosomal complex family	Putative system	104	[56, 194]	8	SNRPC, SRRM1, U2AF2, CDC40, HNRNPU, RNPS1, SRRM2, SRSF10
38	U2 snRNP	Known system	33	[17, 61]	4	CCDC12, SNRPB2, CDC40, SNRPA1
39	Pre-mRNA splicing complex 1	Putative system	64	[34, 119]	4	SNRPB2, CDC40, EXO1, NAA38
40	RNA splicing complex 1	Known system	82	[44, 153]	8	CCDC12, SNRPB2, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1
41	Transcriptional regulation complex family	Putative system	168	[90, 312]	8	SCAND1, ZNF232, ZNF446, ZNF500, ZSCAN16, ZSCAN18, ZNF215, ZNF444
42	Ribosomal complex 6	Putative system	7	[4, 13]	3	RPS18, MRPS14, RPL38
43	Mito-cyto ribosomal cluster	Putative system	20	[11, 38]	7	RPS18, RPL19, RPL27A, MRPS14, RPL38, MRPS31, MRPS9
44	RNA splicing complex 3	Putative system	71	[38, 133]	4	SNRNP70, RPS3A, SRRM1, U2AF2
45	RNA processing complex 1	Putative system	118	[63, 220]	7	RPL13A, DHX15, SNRNP70, RPS3A, ZNF45, SRRM1, U2AF2
46	Histone acetyltransferase complex family	Known system	31	[17, 59]	7	ING4, JAZF1, DMAP1, ING3, MORF4L1, RUVBL2, MYC
47	Large ribosomal subunit subcomplex 4	Known system	5	[3, 10]	6	RPL13A, RPL19, RPL27A, RPL7A, RPL18, RPS3A
48	Large ribosomal subunit subcomplex 1	Putative system	5	[3, 10]	4	RPL27A, MRPL19, MRPL20, RPL38
49	Mitochondrial large ribosomal subunit	Known system	33	[17, 61]	6	RPL27A, MRPL46, MRPS14, MRPL19, MRPL20, RPL38
50	NuA4 histone acetyltransferase complex	Known system	21	[11, 39]	4	DMAP1, ING3, MORF4L1, RUVBL2
51	U1 snRNP	Known system	8	[4, 15]	4	GEMIN7, SNRNP70, SNRPB2, SNRPC
52	Pre-catalytic spliceosome subcomplex 1	Known system	28	[15, 52]	6	CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC
53	Ribosomal complex 5	Putative system	9	[5, 18]	6	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1
54	Zinc finger protein complex	Putative system	90	[48, 167]	4	ZNF446, ZNF500, ZSCAN16, ZSCAN18
55	Transcriptional regulation complexes	Putative system	101	[54, 187]	6	SCAND1, ZNF232, ZNF446, ZNF500, ZSCAN16, ZSCAN18
56	Large ribosomal subunit subcomplex 3	Known system	4	[2, 8]	4	RPL13A, RPL19, RPL27A, RPL7A
57	Nuclear body	Putative system	944	[507, 1759]	21	HNRNPU, HNRNPC, SATB1, DAXX, CHEK1, CTR9, HIRA, NCAPD3, RIF1, SFPQ, SUZ12, XRCC6, TERF1, TRIM27, DDB1, DDX11, NOLC1, PRR14, SMARCC2, UHRF1, XPO1
58	DNA metabolic assembly	Putative system	1242	[667, 2314]	13	RPS18, BCL11A, NASP, SHPRH, EHMT2, RPL7L1, DAXX, XRCC6, SS18L2, GON4L, MMS22L, PARP1, TIPIN
59	Nucleus	Known system	5405	[2902, 10070]	350	RPS18, RPL13A, RPL19, RPL27A, RPL7A, SCAND1, ZNF232, ZNF446, ZNF500, ZSCAN16, ZSCAN18, KRI1, CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, ING4, JAZF1, DMAP1, ING3, MORF4L1, RUVBL2, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, MYC, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, ZNF215, ZNF444, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, RPS13, CD2BP2, GEMIN4, SAFB2, HNRNPC, INO80C, SIN3B, TAF5L, FAM120C, SATB1, BCL11A, FBRSL1, NASP, SHPRH, BCORL1, CASP8AP2, E2F3, EHMT2, SFMBT2, ZNF296, TAF11, AKAP17A, RBBP6, ZRANB2, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, COIL, SF3A2, DR1, SULT1C4, TAF6L, RPL28, RPL11, DAXX, ORC2, POLD1, SMARCAL1, TRIM28, CHEK1, CTR9, EAF1, GTF2B, HIRA, HUS1B, NCAPD3, ORC3, RIF1, SFPQ, SUZ12, XRCC6, PRR3, YTHDC2, ZNF689, PRKRIP1, CASC3, HIRIP3, NOP56, NOS1AP, PRPF31, SH3GL2, MCAT, METTL17, MRPS11, TMLHE, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, RRP7A, ZBTB24, MRPL34, ZC3H10, TERF1, TRIM27, GTF2H4, NSD1, POP7, RBMS1, RFC1, SS18L2, WDR18, ZNF420, GON4L, MMS22L, PARP1, TIPIN, DDB1, DDX11, NOLC1, PRR14, SMARCC2, UHRF1, XPO1, SMARCD2, SCML1, SYMPK, SMAD9, ZNF576, CLASRP, C12orf43, FOXP2, ZNF143, RFXAP, LMX1B, PEF1, LMNB1, ANAPC7, FKBP5, KDM5C, RAVER1, ZNF398, PSMD3, IMP3, FBXL3, PAPLN, BCCIP, C19orf44, KLHL15, CREB5, POLR3E, ZNF580, DCUN1D5, MAD2L2, SUPT4H1, LENG1, ZNF524, FKBPL, JMJD6, HSF2, ZNF281, ZNF829, POLR3H, SYN2, KRBA1, VHL, ARAF, PHF8, HOXD10, PAF1, PNPLA2, MTBP, DLX4, NAF1, CENPT, YDJC, NSMCE4A, PRDM16, SETD7, JMY, NCOR1, POLE, DACH1, PNRC1, ZNF571, SENP3, CDKN2B, CYLD, SMYD3, HEY2, TNRC6C, ARIH2, ZMYM4, ZMYM3, SALL1, C5orf24, AURKB, USF1, TBKBP1, TWIST2, ZNF32, ANKRD54, MAN2C1, KLHDC9, EIF3B, CXXC1, DEAF1, MAU2, DIEXF, ZNF207, RRN3, RARB, NCOA2, ZCCHC12, NUP214, CCDC106, POLR2D, CAMTA2, BRD7, ZNF331, ARID4B, KLF16, PIK3AP1, HLX, DDB2, CDO1, WBP11, PIN1, FIZ1, NPAS1, SOX2, L3MBTL3, GTF2F1, IAH1, MTF2, ZNF212, GPS2, SKI, C7orf25, HOXD4, ZNF280B, NUP85, BAP1, HIC2, OAZ3, EYA3, FIGN, NCAPH2, ZNF593, KDELC1, TRMT11, BCL7A, NUB1, ALKBH2, PITX2, SPTBN4, RAD51C, LYSMD1, SUGP2, DVL2, RUNX1T1, DDX17, IRF2BP1, CCNDBP1, ZBTB40, PDIK1L, PATZ1, IPO11, ZNF629, CAMKMT, SRRT, MAZ, TDP2, POT1, C1orf52, CDKN2A, ZBTB10, PRDM6, GSC, HEY1, COL2A1, THAP3, SOS2, ORC6, DBF4B, BCOR, HOXB7, GTF3C6, RANBP17, HEATR1, UTP18, NSUN5, ZIC2, RNF220, NXF1, ACVR2B, SNAPC4, ZDBF2, TRIM65, HOXC9, CC2D1B, UBE2M, NUP98, FBXO7, FAM122A, LENG8, HIVEP1, MAD2L1BP, FANCL, MLST8, EID1, SEC31B, SALL2, MECOM, WDR26, ZNF579, SNAPC2, ZNF414, HDAC10, MED25, ZNF460, CIR1, NUP133, APBB1
60	Cytoplasm	Known system	9092	[4880, 16938]	379	RPS18, RPL13A, RPL19, RPL27A, RPL7A, SCAND1, ZNF232, ZNF446, ZNF500, ZSCAN16, ZSCAN18, KRI1, DHX15, SNRNP70, RUVBL2, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, ZNF215, ZNF444, HNRNPU, SRSF10, RPS13, HNRNPC, SHPRH, RBBP6, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, RPL28, RPL11, PRR3, YTHDC2, ZNF689, CASC3, NOP56, NOS1AP, ACVR1, AGPAT4, C15orf61, CACNA2D2, GPR180, IGFBP2, IMMT, LMF2, NAT14, PCDH19, PEX10, SH3GL2, SLC35F2, TESC, TMEM177, ANKRD46, CHST10, CLPTM1, DGCR2, DISP1, DNAJC18, FAM69B, FZD8, GABRA5, KCNB2, KCNQ2, MCOLN2, MCOLN3, MFSD10, PDE3B, POMT1, SLC41A3, XKR8, AGK, MCAT, METTL17, MRPS11, NAT8L, NDUFA1, NDUFA10, NDUFA7, NDUFA9, NDUFAF2, NMNAT3, POLRMT, SUCLA2, TIMM50, TMLHE, TOMM40, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, CLASP2, INSIG1, PCDH17, SREBF2, TOR1A, MFF, UQCRQ, CA5B, ECHDC2, TIMM13, VARS2, RRP7A, ZBTB24, AARS2, ADAT3, IBA57, KLHL29, LRP2, PSMG4, TRMU, MRPL34, ZC3H10, CBX6, DTNB, EEF1G, EFHD1, EXOSC8, PICK1, RANGAP1, TERF1, TRABD, TRIM27, USP54, WIPF3, SLC35D3, CAND2, FAM160A2, ARHGAP8, PRKCQ, CSPG5, GDE1, EIF3D, ANAPC5, COCH, ULBP1, SCIN, CSNK1G2, CNNM2, SLC35F1, LRRC34, EGFL8, PDXDC1, COLEC12, COMMD4, LINGO1, EFNB3, FBXL14, RTN1, BPNT1, SYPL2, PUSL1, ZNF747, CES3, SLC6A15, WASF2, GTSE1, WRAP73, SHB, HOXD13, TRAPPC5, ISOC2, DOCK4, LBR, ZNF416, ARMC5, TMEM186, PODXL2, COL4A2, PRKAA2, UCK1, CHAC2, FOXN4, NAMPT, RAB5C, TIAL1, FUZ, TMEM102, CNOT10, HOXB5, SLC2A12, ZNF586, FAM198A, CTU2, CCDC130, C11orf74, CRY1, SDC2, UNC45A, ANTXR1, ZNF620, VRK3, LRRC28, EPN1, MTOR, SBF1, STRN4, HLA-DPB1, PRPSAP1, TMEM222, FAM189B, CUEDC2, SLC25A17, SEPHS2, RC3H2, NOSIP, TRIM11, ZNF324, IL17RD, FAM89A, GTPBP1, AP2A2, HSD17B6, GAD1, C15orf39, GNL1, MAP2K7, EXOC4, FYN, NEFM, OAZ2, COPB1, EIF2B1, MAP1S, CYFIP2, GPR50, TJAP1, PCSK1N, SCRIB, RASGEF1C, ANKFY1, ARVCF, PIGQ, SEPT1, EEF2, MIPOL1, EVL, RPUSD3, VASH2, ABI1, EDA, METTL15, SCAPER, ZNF211, DTNA, EEF1D, DYNC2LI1, IRS2, TPT1, ADD3, CEP68, AGTPBP1, GGA1, CDKAL1, MARCKSL1, FASTKD1, ZNF224, DPYSL5, HEATR3, KLHL22, ENPEP, ANKRD10, CPD, PRKG1, HLA-DPA1, UBXN6, PEX19, TNNI3, ARMC6, CHCHD7, DYNC1LI2, FHIT, TGFBRAP1, DCAKD, RB1CC1, IREB2, MYH10, DCP1B, PPP6R1, GAL, RANBP1, SEC63, PTOV1, C8orf34, AMPD2, EIF5B, S1PR2, WWOX, TRO, MON1A, ZNF813, DAAM2, DYNC1I2, C19orf25, ACBD7, ZDHHC17, RADIL, QRSL1, ERI3, ARC, PDF, MAP3K15, ZNF266, DNAJA3, TP73, ANKLE2, EPHA3, BSG, SLAIN1, PAIP2B, COPS4, PACSIN1, ANKRD13B, ASB13, BLOC1S3, NEK3, LAMP3, PHKG2, NUF2, LRP1B, CD320, SGSM3, GLB1L2, SUSD5, MUC5AC, CHPT1, SERGEF, FAM184A, AP1B1, SLC37A3, FKBP10, CKB, PLCH1, NELL2, PDCD2, RHBDL1, MRRF, PHLPP2, GIGYF2, TARSL2, QPCT, KIF1A, UXT, ARHGEF25, RNF167, ZC4H2, CD72, EDC4, BHLHA15, KIDINS220, CTTNBP2, GFAP, PALM, WDR90, CSPP1, UBL7, ARRB2, DDI2, CAMK1, ID4, SYAP1, ALDH8A1, PSMC2, KIAA2013
61	Cell	Known system	9092	[4880, 16938]	661	RPS18, RPL13A, RPL19, RPL27A, RPL7A, SCAND1, ZNF232, ZNF446, ZNF500, ZSCAN16, ZSCAN18, KRI1, CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, ING4, JAZF1, DMAP1, ING3, MORF4L1, RUVBL2, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, MYC, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, ZNF215, ZNF444, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, RPS13, CD2BP2, GEMIN4, SAFB2, HNRNPC, INO80C, SIN3B, TAF5L, FAM120C, SATB1, BCL11A, FBRSL1, NASP, SHPRH, BCORL1, CASP8AP2, E2F3, EHMT2, SFMBT2, ZNF296, TAF11, AKAP17A, RBBP6, ZRANB2, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, COIL, SF3A2, DR1, SULT1C4, TAF6L, RPL28, RPL11, DAXX, ORC2, POLD1, SMARCAL1, TRIM28, CHEK1, CTR9, EAF1, GTF2B, HIRA, HUS1B, NCAPD3, ORC3, RIF1, SFPQ, SUZ12, XRCC6, PRR3, YTHDC2, ZNF689, PRKRIP1, CASC3, HIRIP3, NOP56, NOS1AP, PRPF31, ACVR1, AGPAT4, C15orf61, CACNA2D2, GPR180, IGFBP2, IMMT, LMF2, NAT14, PCDH19, PEX10, SH3GL2, SLC35F2, TESC, TMEM177, ANKRD46, CHST10, CLPTM1, DGCR2, DISP1, DNAJC18, FAM69B, FZD8, GABRA5, KCNB2, KCNQ2, MCOLN2, MCOLN3, MFSD10, PDE3B, POMT1, SLC41A3, XKR8, AGK, MCAT, METTL17, MRPS11, NAT8L, NDUFA1, NDUFA10, NDUFA7, NDUFA9, NDUFAF2, NMNAT3, POLRMT, SUCLA2, TIMM50, TMLHE, TOMM40, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, CLASP2, INSIG1, PCDH17, SREBF2, TOR1A, MFF, UQCRQ, CA5B, ECHDC2, TIMM13, VARS2, RRP7A, ZBTB24, AARS2, ADAT3, IBA57, KLHL29, LRP2, PSMG4, TRMU, MRPL34, ZC3H10, CBX6, DTNB, EEF1G, EFHD1, EXOSC8, PICK1, RANGAP1, TERF1, TRABD, TRIM27, USP54, WIPF3, GTF2H4, NSD1, POP7, RBMS1, RFC1, SS18L2, WDR18, ZNF420, GON4L, MMS22L, PARP1, TIPIN, DDB1, DDX11, NOLC1, PRR14, SMARCC2, UHRF1, XPO1, SLC35D3, CAND2, FAM160A2, ARHGAP8, PRKCQ, CSPG5, GDE1, EIF3D, ANAPC5, COCH, ULBP1, SCIN, CSNK1G2, CNNM2, SLC35F1, LRRC34, EGFL8, PDXDC1, COLEC12, COMMD4, LINGO1, EFNB3, FBXL14, RTN1, BPNT1, SYPL2, PUSL1, ZNF747, CES3, SLC6A15, WASF2, GTSE1, WRAP73, SHB, HOXD13, TRAPPC5, ISOC2, DOCK4, LBR, ZNF416, ARMC5, TMEM186, PODXL2, COL4A2, PRKAA2, UCK1, CHAC2, FOXN4, NAMPT, RAB5C, TIAL1, FUZ, TMEM102, CNOT10, HOXB5, SLC2A12, ZNF586, FAM198A, CTU2, CCDC130, C11orf74, CRY1, SDC2, UNC45A, ANTXR1, ZNF620, VRK3, LRRC28, EPN1, MTOR, SBF1, STRN4, HLA-DPB1, PRPSAP1, TMEM222, FAM189B, CUEDC2, SLC25A17, SEPHS2, RC3H2, NOSIP, TRIM11, ZNF324, IL17RD, FAM89A, GTPBP1, AP2A2, HSD17B6, GAD1, C15orf39, GNL1, MAP2K7, EXOC4, FYN, NEFM, OAZ2, COPB1, EIF2B1, MAP1S, CYFIP2, GPR50, TJAP1, PCSK1N, SCRIB, RASGEF1C, ANKFY1, ARVCF, PIGQ, SEPT1, EEF2, MIPOL1, EVL, RPUSD3, VASH2, ABI1, EDA, METTL15, SCAPER, ZNF211, DTNA, EEF1D, DYNC2LI1, IRS2, TPT1, ADD3, CEP68, AGTPBP1, GGA1, CDKAL1, MARCKSL1, FASTKD1, ZNF224, DPYSL5, HEATR3, KLHL22, ENPEP, ANKRD10, CPD, PRKG1, HLA-DPA1, UBXN6, PEX19, TNNI3, ARMC6, CHCHD7, DYNC1LI2, FHIT, TGFBRAP1, DCAKD, RB1CC1, IREB2, MYH10, DCP1B, PPP6R1, GAL, RANBP1, SEC63, PTOV1, C8orf34, AMPD2, EIF5B, S1PR2, WWOX, TRO, MON1A, ZNF813, DAAM2, DYNC1I2, C19orf25, ACBD7, ZDHHC17, RADIL, QRSL1, ERI3, ARC, PDF, MAP3K15, ZNF266, DNAJA3, TP73, ANKLE2, EPHA3, BSG, SLAIN1, PAIP2B, COPS4, PACSIN1, ANKRD13B, ASB13, BLOC1S3, NEK3, LAMP3, PHKG2, NUF2, LRP1B, CD320, SGSM3, GLB1L2, SUSD5, MUC5AC, CHPT1, SERGEF, FAM184A, AP1B1, SLC37A3, FKBP10, CKB, PLCH1, NELL2, PDCD2, RHBDL1, MRRF, PHLPP2, GIGYF2, TARSL2, QPCT, KIF1A, UXT, ARHGEF25, RNF167, ZC4H2, CD72, EDC4, BHLHA15, KIDINS220, CTTNBP2, GFAP, PALM, WDR90, CSPP1, UBL7, ARRB2, DDI2, CAMK1, ID4, SYAP1, ALDH8A1, PSMC2, KIAA2013, SMARCD2, SCML1, SYMPK, SMAD9, ZNF576, CLASRP, C12orf43, FOXP2, ZNF143, RFXAP, LMX1B, PEF1, LMNB1, ANAPC7, FKBP5, KDM5C, RAVER1, ZNF398, PSMD3, IMP3, FBXL3, PAPLN, BCCIP, C19orf44, KLHL15, CREB5, POLR3E, ZNF580, DCUN1D5, MAD2L2, SUPT4H1, LENG1, ZNF524, FKBPL, JMJD6, HSF2, ZNF281, ZNF829, POLR3H, SYN2, KRBA1, VHL, ARAF, PHF8, HOXD10, PAF1, PNPLA2, MTBP, DLX4, NAF1, CENPT, YDJC, NSMCE4A, PRDM16, SETD7, JMY, NCOR1, POLE, DACH1, PNRC1, ZNF571, SENP3, CDKN2B, CYLD, SMYD3, HEY2, TNRC6C, ARIH2, ZMYM4, ZMYM3, SALL1, C5orf24, AURKB, USF1, TBKBP1, TWIST2, ZNF32, ANKRD54, MAN2C1, KLHDC9, EIF3B, CXXC1, DEAF1, MAU2, DIEXF, ZNF207, RRN3, RARB, NCOA2, ZCCHC12, NUP214, CCDC106, POLR2D, CAMTA2, BRD7, ZNF331, ARID4B, KLF16, PIK3AP1, HLX, DDB2, CDO1, WBP11, PIN1, FIZ1, NPAS1, SOX2, L3MBTL3, GTF2F1, IAH1, MTF2, ZNF212, GPS2, SKI, C7orf25, HOXD4, ZNF280B, NUP85, BAP1, HIC2, OAZ3, EYA3, FIGN, NCAPH2, ZNF593, KDELC1, TRMT11, BCL7A, NUB1, ALKBH2, PITX2, SPTBN4, RAD51C, LYSMD1, SUGP2, DVL2, RUNX1T1, DDX17, IRF2BP1, CCNDBP1, ZBTB40, PDIK1L, PATZ1, IPO11, ZNF629, CAMKMT, SRRT, MAZ, TDP2, POT1, C1orf52, CDKN2A, ZBTB10, PRDM6, GSC, HEY1, COL2A1, THAP3, SOS2, ORC6, DBF4B, BCOR, HOXB7, GTF3C6, RANBP17, HEATR1, UTP18, NSUN5, ZIC2, RNF220, NXF1, ACVR2B, SNAPC4, ZDBF2, TRIM65, HOXC9, CC2D1B, UBE2M, NUP98, FBXO7, FAM122A, LENG8, HIVEP1, MAD2L1BP, FANCL, MLST8, EID1, SEC31B, SALL2, MECOM, WDR26, ZNF579, SNAPC2, ZNF414, HDAC10, MED25, ZNF460, CIR1, NUP133, APBB1
62	Nuclear lumen	Known system	2330	[1250, 4340]	88	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, RPS13, CD2BP2, GEMIN4, SAFB2, HNRNPC, SFMBT2, AKAP17A, RBBP6, ZRANB2, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, COIL, SF3A2, RPL28, RPL11, DAXX, PRR3, YTHDC2, ZNF689, PRKRIP1, CASC3, HIRIP3, NOP56, NOS1AP, PRPF31, SH3GL2, MCAT, METTL17, MRPS11, TMLHE, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, RRP7A, ZBTB24, MRPL34, ZC3H10, GTF2H4, NSD1, POP7, RBMS1, RFC1, SS18L2, WDR18, ZNF420
63	Cytoplasmic organelles	Putative system	3307	[1775, 6161]	98	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, DHX15, SNRNP70, RUVBL2, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, HNRNPU, SRSF10, RPS13, HNRNPC, SHPRH, RBBP6, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, RPL28, RPL11, PRR3, YTHDC2, ZNF689, CASC3, NOP56, NOS1AP, IMMT, SH3GL2, AGK, MCAT, METTL17, MRPS11, NAT8L, NDUFA1, NDUFA10, NDUFA7, NDUFA9, NDUFAF2, NMNAT3, POLRMT, SUCLA2, TIMM50, TMLHE, TOMM40, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, CLASP2, TOR1A, MFF, UQCRQ, CA5B, ECHDC2, TIMM13, VARS2, RRP7A, ZBTB24, AARS2, ADAT3, IBA57, KLHL29, LRP2, PSMG4, TRMU, MRPL34, ZC3H10, CBX6, DTNB, EEF1G, EFHD1, EXOSC8, PICK1, RANGAP1, TERF1, TRABD, TRIM27, USP54, WIPF3
64	Nucleolus	Known system	1776	[953, 3308]	75	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, CCDC12, DHX15, GEMIN7, SNRNP70, SNRPB2, SNRPC, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, DHX8, RNPC3, CDC40, EXO1, NAA38, SNRPA1, HNRNPU, RNPS1, SRRM2, SRSF10, RPS13, CD2BP2, GEMIN4, SAFB2, HNRNPC, SFMBT2, AKAP17A, RBBP6, ZRANB2, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, COIL, SF3A2, RPL28, RPL11, PRR3, YTHDC2, ZNF689, PRKRIP1, NOP56, PRPF31, MCAT, METTL17, MRPS11, TMLHE, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, RRP7A, ZBTB24, MRPL34, ZC3H10
65	Subgroup of cytoplasmic organelles	Putative system	2515	[1350, 4686]	76	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, DHX15, SNRNP70, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, RPS13, HNRNPC, RBBP6, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, RPL28, RPL11, PRR3, YTHDC2, ZNF689, NOP56, IMMT, SH3GL2, AGK, MCAT, METTL17, MRPS11, NAT8L, NDUFA1, NDUFA10, NDUFA7, NDUFA9, NDUFAF2, NMNAT3, POLRMT, SUCLA2, TIMM50, TMLHE, TOMM40, URB2, YARS2, C19orf53, ZCCHC9, LIN28B, MFF, UQCRQ, CA5B, ECHDC2, TIMM13, VARS2, RRP7A, ZBTB24, AARS2, ADAT3, IBA57, KLHL29, LRP2, PSMG4, TRMU
66	Ribonucleoprotein complex family	Known system	482	[259, 899]	43	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, DHX15, SNRNP70, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, U2AF2, MRPS31, MRPS9, RPL6, RPS13, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, RPL28, RPL11, PRR3, YTHDC2, ZNF689, NOP56, MCAT, URB2, C19orf53, ZCCHC9, LIN28B, RRP7A, ZBTB24
67	Mitochondrion	Putative system	1081	[580, 2014]	14	MRPL46, MRPL19, IMMT, MCAT, NDUFA1, NDUFA10, NDUFA7, NDUFA9, SUCLA2, TOMM40, CA5B, ECHDC2, TIMM13, VARS2
68	Metabolic organelles	Known system	1835	[985, 3418]	48	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, MRPS31, MRPS9, RPL6, RPS13, HNRNPC, RBBP6, NOC2L, RPL28, RPL11, IMMT, AGK, MCAT, METTL17, MRPS11, NAT8L, NDUFA1, NDUFA10, NDUFA7, NDUFA9, NDUFAF2, NMNAT3, POLRMT, SUCLA2, TIMM50, TMLHE, TOMM40, URB2, YARS2, C19orf53, MFF, UQCRQ, CA5B, ECHDC2, TIMM13, VARS2
69	Secretory organelles	Putative system	3994	[2144, 7440]	39	ACVR1, AGPAT4, C15orf61, CACNA2D2, GPR180, IGFBP2, IMMT, LMF2, NAT14, PCDH19, PEX10, SH3GL2, SLC35F2, TESC, TMEM177, ANKRD46, CHST10, CLPTM1, DGCR2, DISP1, DNAJC18, FAM69B, FZD8, GABRA5, KCNB2, KCNQ2, MCOLN2, MCOLN3, MFSD10, PDE3B, POMT1, SLC41A3, XKR8, NDUFA1, CLASP2, INSIG1, PCDH17, SREBF2, TOR1A
70	Nucleic acid binding complex	Putative system	146	[78, 271]	5	ZNF45, RPS13, PRR3, YTHDC2, ZNF689
71	Ribosome biogenesis community	Known system	347	[186, 646]	36	RPS18, RPL13A, RPL19, RPL27A, RPL7A, KRI1, DHX15, MRPL46, MRPS14, MRPL19, MRPL20, RPL38, RPL18, RPS3A, ZNF45, SRRM1, MRPS31, MRPS9, RPS13, RRS1, NOC2L, NVL, REXO4, RPL7L1, DHX37, NOL12, ZNF771, RPL28, RPL11, PRR3, YTHDC2, ZNF689, NOP56, C19orf53, ZCCHC9, LIN28B
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