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TitleLay Language SummaryDate of PublicationURLDOICitationLead Author Email
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Factors associated with syphilis seroprevalence in women with and at-risk for HIV infection in the Women's Interagency HIV Study (1994-2015)Syphilis rates among women in the United States have more than doubled between 2014 and 2018. Researchers studied characteristics of syphilis among women enrolled in the United States Women's Interagency HIV Study (WIHS). Knowledge obtained from this study will help healthcare professionals to identify women that should be screened for syphilis. The study included women with HIV or at-risk of HIV who enrolled in WIHS between the years of 1994 and 2015. There were 3692 women from the early phase (years 1994-2002) and 1182 women from the recent phase (years 2011-2015) included in the study. Syphilis screening was performed at enrollment and infection was confirmed by two testing mechanisms. Characteristics at enrollment were compared for women by the presence of syphilis infection in each study phase. Researchers used statistical models to see which of these factors were most closely associated with syphilis infection. The prevalence of syphilis at enrollment was 7.5% in the early phase and 3.7% in the most recent phase. In the study’s early phase, syphilis was related to HIV-infection, being of black race, having a low income, or trading sex for drugs, money, or shelter. In the study’s recent phase, syphilis was linked to older age, problem alcohol use, and being infected with hepatitis C. Findings from the study’s recent phase showed that there may be a benefit from regular syphilis screening among women with and at-risk for HIV who abuse drugs and alcohol.February 2022https://pubmed.ncbi.nlm.nih.gov/33408096/
10.1136/sextrans-2020-054674
Kristal J Aaron, Ilene Brill, Zenoria Causey-Pruitt, Kerry Murphy 4, Michael Augenbraun, Seble Kassaye, Joel E Milam, Dominika Seidman, Audrey L French, Stephen J Gange, Adaora A Adimora, Anandi N Sheth, Margaret A Fischl, Barbara Van Der Pol, Jeanne Marrazzo, Mirjam-Colette Kempf, Jodie Dionne-Odom (2021). Factors associated with syphilis seroprevalence in women with and at-risk for HIV infection in the Women's Interagency HIV Study (1994-2015). Sex Transm Infect, (), . kjaaron@uab.edu
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Social-environmental resiliencies protect against loneliness among HIV-Positive and HIV- negative older men who have sex with men: Results from the Multicenter AIDS Cohort Study (MACS)Loneliness is linked with negative health outcomes among HIV-positive and HIV-negative older men who have sex with men. It is important to identify the factors that help decrease loneliness in these groups. We examined whether resilience—defined as an individual’s level of support, social bonding, and a sense of community among gay men—protect against symptoms of loneliness. We analyzed data from 1,255 middle-aged and older MSM with and without HIV infection who were enrolled in the Multicenter AIDS Cohort Study. We identified three underlying classes (Social Connectors, Non-community Connectors, and Social Isolates) in the social environment of the sample. Results showed that compared to Social Connectors with high levels of social support and social bonding, and a strong perceived sense of community, Social Isolates and Non-community Connectors were more likely to experience loneliness. There were no differences by HIV status. Developing individual- and community-level tailored programs for these populations that focus on social environmental resilience is key to reducing loneliness and promoting health.March 2021https://pubmed.ncbi.nlm.nih.gov/33550066/
10.1016/j.socscimed.2021.113711
Maria De Jesus, Deanna Ware, Andre L Brown, James E Egan, Sabina A Haberlen, Frank Joseph Palella Jr, Roger Detels, M Reuel Friedman, Michael W Plankey (2021). Social-environmental resiliencies protect against loneliness among HIV-Positive and HIV- negative older men who have sex with men: Results from the Multicenter AIDS Cohort Study (MACS). Soc Sci Med, (), 272. dejesus@american.edu
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The effect of discrimination and resilience on depressive symptoms among middle-aged and older men who have sex with menOur study found differences in average resilience scores across visits; an association between lower depressive symptoms and higher average resilience and greater change in resilience score over time; and an association between experiencing homophobia and greater depressive symptoms in a sample of middle-aged and older MSM.2022
https://psycnet.apa.org/record/2021-67991-001
10.1037/sah0000327Brown, A. L., Matthews, D. D., Meanley, S., Brennan-Ing, M., Haberlen, S., D'Souza, G., Ware, D., Egan, J., Shoptaw, S., Teplin, L. A., Friedman, M. R., & Plankey, M. (2021). The effect of discrimination and resilience on depressive symptoms among middle-aged and older men who have sex with men. Stigma and Health, (), . abrown7@pitt.edu
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Menopausal status and observed differences in the gut microbiome in women with and without HIV infectionSome people with HIV experience food insecurity, which means they have limited access to healthy foods. People living with HIV that have food insecurity seem to be at higher risk of disease and mortality, but the reason for this is not clear. We did a study in women living with HIV, to test whether food insecurity is related to the levels of certain types of immune cells in the blood. Higher levels of these immune cells indicate an unhealthy immune system. We found that women with food insecurity had higher levels of unhealthy immune cells in their blood. This could mean food insecurity leads to disease risk by effecting the immune system.January 2021https://pubmed.ncbi.nlm.nih.gov/33438892/
10.1097/GME.0000000000001730
Peters BA, Xue X, Wang Z, Usyk M, Santoro N, Sharma A, Anastos K, Tien PC, Golub ET, Weber KM, Gustafson D, Kaplan RC, Burk R, Qi Q (2021). Menopausal status and observed differences in the gut microbiome in women with and without HIV infection. The Journal of The North American Menopause Society, 28(5), 491-501. PMC8068580brandilyn.peterssamuelson@einsteinmed.org
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Cognitive changes during the menopausal transition: a longitudinal study in women with and without HIVMany, but not all, women with HIV experience difficulties with memory and other cognitive abilities. One factor unique to women that can influence cognitive abilities is menopause, the time in a woman's life when her period stops. Menopause happens because the woman's ovaries stop producing the hormones estrogen and progesterone. Changes in these hormones can influence cognition but the effects of menopause on cognition had not previously been studied in women with HIV. Here we show that women with HIV, and women without HIV, experience decreases in learning, memory, and attention as they go through the menopause "change". These findings help us to understand the range of factors that can influence cognition in women with HIV.January 2021https://pubmed.ncbi.nlm.nih.gov/33438895/
10.1097/GME.0000000000001725
Pauline M Maki, Gayle Springer, Kathryn Anastos, Deborah R Gustafson, Kathleen Weber, David Vance, Derek Dykxhoorn, Joel Milam, Adaora A Adimora, Seble G Kassaye, Drenna Waldrop, Leah H Rubin (2021). Cognitive changes during the menopausal transition: a longitudinal study in women with and without HIV. Menopause, (), . pmaki1@uic.edu
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G-computation for policy-relevant effects of interventions on time-to-event outcomesA goal of many health studies is to determine the effects of realistic policies or interventions. In the last three decades, there have been major advances in methods that can be used for this goal. Unfortunately, they are often seen as complicated and are not commonly used. We demonstrate how one of these methods be implemented quite easily in common settings. We use the method to estimate the effect of neighborhoods on acquiring sexually transmitted infections.January 2021https://pubmed.ncbi.nlm.nih.gov/33141177/10.1093/ije/dyaa156Alexander Breskin, Andrew Edmonds, Stephen R Cole, Daniel Westreich, Jennifer Cocohoba, Mardge H Cohen, Seble G Kassaye, Lisa R Metsch, Anjali Sharma, Michelle S Williams, Adaora A Adimora (2021). G-computation for policy-relevant effects of interventions on time-to-event outcomes. Int J Epidemiol, 49(6), 2021-2029. PMC7825964abreskin@email.unc.edu
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Staying or moving: Results of a latent transition analysis examining intra-individual stability of recreational substance use among MSM in the Multicenter AIDS Cohort Study from 2004 to 2016Men who have sex with men (MSM) are at higher risk of HIV/ sexually transmitted infections (STIs) compared to the other at-risk populations, especially in North America. Among MSM, condomless anal sex (CAS) is the key factor for HIV/STI transmission, but several other factors such as, anxiety, depression, childhood bullying and abuse experiences, experiences of violence and victimization and recreational substance (ab)use contribute to the increased CAS. Some MSM prefer to use one substance over another and use it consistently, however, using multiple substances simultaneously, or moving from one substance to another substance over time is not uncommon among MSM. Knowing what substance or class of substances MSM use and whether they keep using the same substance over time or transitioning into different substance might have practical relevance. In this study, we calculated the prevalence of substance use among a large sample of US MSM with and without HIV over a 12-year time period (2004-2016), and examined if there is a change in substance use over time. Our results show, that substance use was common. Alcohol was the most reported substance of use followed by poppers, marijuana, sexual performance-enhancing medications, stimulants (crystal, methamphetamines, speed, ice), cocaine, and heroin. We observe an overall decline in cocaine, and sexual performance-enhancing medications use but an increase in marijuana and heroin use over time. We also observe that a majority of MSM kept using the same substance over longer periods of time, but some MSM changed their choice of substance over time. We see younger MSM were more likely to use more substances whereas older MSM were more likely to use none or only alcohol. White MSM were more likely to move from one substance use to another substance use compared to non-white MSM. However, we do not see any differences on moving from one substance use to another use by HIV-status.January 2021https://pubmed.ncbi.nlm.nih.gov/33485009/
10.1016/j.drugalcdep.2021.108516
Syed W Noor, Trevor A Hart, Chukwuemeka N Okafor, Deanna Ware, Kara W Chew, Gypsyamber D'Souza, Ken Ho, M Reuel Friedman, Michael Plankey (2021). Staying or moving: Results of a latent transition analysis examining intra-individual stability of recreational substance use among MSM in the Multicenter AIDS Cohort Study from 2004 to 2016. Drug Alcohol Depend, (), . PMC7901540snoor@psych.ryerson.ca
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A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across Six Cities in the Women's Interagency HIV Study: Intersections with Current and Past Injectable Medication and Substance UseMedications for HIV treatment and prevention are currently daily pills which can make adherence challenging. Long-acting injectable (LAI) forms of antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) have been developed, but almost no research on this topic has occurred among women, both inside and outside of clinical trials. As a result, little is known about how women’s prior history of injection use, whether for medical or non-medical purposes, may influence their interest in LAI. We conducted 89 in-depth interviews at six WIHS sites (New York, NY; Chicago, IL; San Francisco, CA; Atlanta, GA; Chapel Hill, NC; Washington, D.C.). Interviews occurred with women living with HIV (WLWH) (n=59) and HIV-negative women (n=30) from November 2017–October 2018. Interviews were recorded, transcribed, and we read the interview transcripts to analyze them for relevant themes. We found that women’s prior experiences with injections occurred primarily through substance use, as a result of physical comorbidities (e.g., diabetes, Hepatitis C), birth control (Depo-Provera), or flu vaccines. Four primary categories of women emerged; those who: 1) received injections infrequently (e.g., birth control, physical comorbidities) and had few concerns about injectable medication; 2) required frequent injections (e.g., diabetes) and would refuse additional injectable medication; 3) had a history of injection drug use. Some of women with a history of injection drug use were worried using injectable medication could trigger relapse, but others said it would not be a problem; and 4) were currently injecting drugs and had few concerns about injectable medication. Most women with a history of injectable medication would prefer LAI, but those with other frequent injections (e.g., for diabetes) would not. Women with a history of injection drug use were mixed on their response to LAI. Future research needs to address injection-related concerns, and develop patient-centered approaches to help providers best identify which women could benefit from LAI use.January 2021https://pubmed.ncbi.nlm.nih.gov/33400587/10.1089/apc.2020.0164Morgan M Philbin, Carrigan Parish, Sadie Bergen, Deanna Kerrigan, Elizabeth N Kinnard, Sarah E Reed, Mardge H Cohen, Oluwakemi Sosanya, Anandi N Sheth, Adaora A Adimora, Jennifer Cocohoba, Lakshmi Goparaju, Elizabeth T Golub, Margaret Fischl, Maria L Alcaide, Lisa R Metsch (2021). A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across Six Cities in the Women's Interagency HIV Study: Intersections with Current and Past Injectable Medication and Substance Use. AIDS Patient Care STDS, 35(1), 23-30. PMC7826427mp3243@cumc.columbia.edu
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Employment and Occupational Productivity Among Women Living With HIV: A Conceptual FrameworkWork provides people with a sense of purpose, and may improve health and quality of life. While many people living with HIV are able to work, women living with HIV sometimes have difficulty getting a job and keeping a job. To understand why, we looked at the physical and mental health of women living with HIV, and asked employed women living with HIV about their work experiences. Overall, we found that work was a positive experience, and helped women provide for their families and feel proud of themselves. When women felt they were in control of their personal and work lives, they were happier with work, and felt more productive. Being able to set personal boundaries, and strategically using emotional coping and problem solving skill sets helped women to be more productive in their work, and feel like they had more work-life balance. We were also pleased to find most women felt like HIV had little or no impact on their work, and were able to keep their health as a top priority while working.January 2021https://pubmed.ncbi.nlm.nih.gov/32852297/
10.1097/JNC.0000000000000202
Jenni M Wise, David E Vance, Karen Heaton, James L Raper, Deborah Konkle-Parker, Andres Azuero, Mirjam-Colette Kempf (2021). Employment and Occupational Productivity Among Women Living With HIV: A Conceptual Framework. J Assoc Nurses AIDS Care, 32(1), 37-46. jmwise@uab.edu
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The combined effects of age and HIV on the anatomic distribution of cortical and cancellous bone in the femoral neck among men and womenThis study looked at HIV- and age- related differences in hip bone structure in men and women. We examined bone thickness (CT) and bone mineral density across the hip bone in older adult men and women with (PWH) and without (PWOH) HIV infection. Among men we didn't see differences by HIV serostatus, though all the men had thinner and less dense bones than expected. But among women, those living with HIV had thinner and less dense bones across the hip. The bone was 10 to 20% thinner, and they were especially thin on the top of the hip where many fractures happen. Bone strength in the hip may be thin in men who have sex with men, regardless of their HIV status. Women who are living with HIV appear to have a thinner and less dense hip bones in areas that are most prone to fractureDecember 2021https://pubmed.ncbi.nlm.nih.gov/34482349/
10.1097/QAD.0000000000003061
Alison G Abraham, Jing Sun, Anjali Sharma, Michael T Yin, J Keenan Brown, Shadpour Demehri, Joshua Garza, Jayesh G Shah, Frank J Palella, Lawrence Kingsley, Beth D Jamieson, Keri N Althoff, Todd T Brown
alison.abraham@cuanschutz.edu
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