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Dog Common Finding List for Toxicity Study　（イヌ一般毒性試験用常用所見集）
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Organ systemOrgan Findings
　　紫字: SEND&INHAND共通用語
　　橙色字: INHAND用語
　　緑字: SEND term
　　黒字：毒性病理組織学/委員会提案		　　　　　　　Modifier　
　　
　
　　橙色字: INHAND用語　　
　　黒字：　委員会提案		Remarks


備考
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Cardio-vascularAortamineralizationmedia; wall; etc.
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Cardio-vascularHeartarteritis
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Cardio-vascularHeartarteritis/polyarteritis
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Cardio-vascularHeartdegeneration, cardiomyocytehyaline; vacuolar; fatty; etc.
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Cardio-vascularHeartdegeneration/necrosis, cardiomyocyte
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Cardio-vascularHeartedema, myocardiuminterstitial
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Cardio-vascularHeartfibrosis, myocardium
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Cardio-vascularHearthemorrhagesubendocardial; epicardial; myocardial; valve; etc.
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Cardio-vascularHearthyperplasia, mesotheliumepicardium or pericardium
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Cardio-vascularHearthypertrophy, cardiomyocyte
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Cardio-vascularHeartinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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Cardio-vascularHeartmineralization, cardiomyocyte (myocardium)
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Cardio-vascularHeartmineralization, medial or mural artery
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Cardio-vascularHeartnecrosis/infiltratecell type(s); cardiomyocyte
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Cardio-vascularHeartpigment, cardiomyocyte or myocardium
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Cardio-vascularHeartthrombusatrium
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Cardio-vascularHeartvacuolation, cardiomyocyte
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DigestiveTongueapoptosis/single cell necrosissquamous epitheliumApoptosis, necrosisの区別がつく場合は単独で記載
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DigestiveTongueatrophy, squamous epithelium
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DigestiveTonguedegeneration/necrosis, muscle fiber
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DigestiveTongueedema
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DigestiveTongueerosion/ulcer明らかな区別がつく場合は単独で記載
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DigestiveTonguehyperkeratosis
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DigestiveTonguehyperplasia, squamous cell
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DigestiveTongueinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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DigestiveEsophagusapoptosis/single cell necrosissquamous epitheliumApoptosis, necrosisの区別がつく場合は単独で記載
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DigestiveEsophagusatrophy, squamous epithelium
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DigestiveEsophagusdegeneration/necrosis, muscle
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DigestiveEsophagusedema
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DigestiveEsophaguserosion/ulcer明らかな区別がつく場合は単独で記載
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DigestiveEsophagushyperplasia, squamous cell
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DigestiveEsophagusinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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DigestiveStomachapoptosis/single cell necrosisApoptosis, necrosisの区別がつく場合は単独で記載
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DigestiveStomachatrophymucosa
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DigestiveStomachcellularity Increased, lymphocyte
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DigestiveStomachcyst, glandular
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DigestiveStomachedemamucosa; submucosa; etc.
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DigestiveStomacherosion/ulcer明らかな区別がつく場合は単独で記載
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DigestiveStomachhemorrhage
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DigestiveStomachhyperplasia, + cell types(s)mucosa; chief cell; parietal cell; mucous cells; etc. + focal; diffuse + regenerative; etc.
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DigestiveStomachhyperplasia, neuroendocrine cell
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DigestiveStomachhypertrophy, mucous cell
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DigestiveStomachinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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DigestiveStomachmineralization
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DigestiveStomachregeneration, glandular epithelium
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DigestiveStomachsingle cell necrosisglandular epithelium
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DigestiveStomachvacuolation, + cell type(s)mucosa; chief cell; parietal cell; mucous cells; etc.
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DigestiveSmall intestine; duodenum, jejunum, ileumapoptosis/single cell necrosismucosaApoptosis, necrosisの区別がつく場合は単独で記載
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DigestiveSmall intestine; duodenum, jejunum, ileumatrophyvillous; mucosa; Brunner's gland
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DigestiveSmall intestine; duodenum, jejunum, ileumdilatationcrypt; lumen; etc.
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DigestiveSmall intestine; duodenum, jejunum, ileumectopic tissuefundic gland; pancreas
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DigestiveSmall intestine; duodenum, jejunum, ileumerosion/ulcer明らかな区別がつく場合は単独で記載
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DigestiveSmall intestine; duodenum, jejunum, ileumhyperplasiavillous; mucosa; atypical; goblet cell etc.
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DigestiveSmall intestine; duodenum, jejunum, ileumhypertrophyvillous; mucosa; etc.
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DigestiveSmall intestine; duodenum, jejunum, ileuminfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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DigestiveSmall intestine; duodenum, jejunum, ileummineralization
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DigestiveSmall intestine; duodenum, jejunum, ileumnecrosis, mucosa
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DigestiveSmall intestine; duodenum, jejunum, ileumregeneration, mucosa
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DigestiveSmall intestine; duodenum, jejunum, ileumsingle cell necrosismucosa
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DigestiveSmall intestine; duodenum, jejunum, ileumvacuolation, mucosa
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DigestiveLarge intestine; cecum, colon, rectumapoptosis/single cell necrosismucosaApoptosis, necrosisの区別がつく場合は単独で記載
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DigestiveLarge intestine; cecum, colon, rectumatrophymucosa
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DigestiveLarge intestine; cecum, colon, rectumdilatationlumen, etc.
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DigestiveLarge intestine; cecum, colon, rectumerosion/ulcer明らかな区別がつく場合は単独で記載
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DigestiveLarge intestine; cecum, colon, rectumhyperplasia, mucosa
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DigestiveLarge intestine; cecum, colon, rectumhypertrophy, mucosa
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DigestiveLarge intestine; cecum, colon, rectuminfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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DigestiveLarge intestine; cecum, colon, rectummineralization
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DigestiveLarge intestine; cecum, colon, rectumnecrosis, mucosa
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DigestiveLarge intestine; cecum, colon, rectumregeneration, mucosa
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DigestiveLarge intestine; cecum, colon, rectumsingle cell necrosismucosa
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DigestiveLarge intestine; cecum, colon, rectumvacuolation, mucosa
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DigestiveLiveraccumulation (rarefaction), glycogen hepatocyte
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DigestiveLiveratrophyhepatocyte
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DigestiveLiverbile plug
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DigestiveLiverextramedullary hematopoiesis
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DigestiveLiverfatty changehepatocyte
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DigestiveLiverfibrosis
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DigestiveLiverhyperplasia, + cell type(s)bile duct; Ito cell; oval cell; etc.
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DigestiveLiverhypertrophy, hepatocytecentrilobular; periportal; midzonal; diffuse
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DigestiveLiverhypertrophy/hyperplasia, Kupffer cell
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DigestiveLiverinclusionintranuclear and cytoplasmic; intranuclear brick; intranuclear; cytoplasmic
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DigestiveLiverinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc. + Glisson sheath; perivascular; peribiliary; etc.
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DigestiveLiverkaryomegaly/multinucleated hepatocytes
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DigestiveLivermicrogranuloma (granuloma)
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DigestiveLivermitotic figures, increasedhepatocyte
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DigestiveLivernecrosis, +zonalcentrilobular; periportal; midzonal
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DigestiveLivernecrosis, focal/multifocal
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DigestiveLiverpigmentlipofuscin; hemosiderin; etc. + hepatocyte; Kupffer cell
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DigestiveLiversingle cell necrosishepatocyte
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DigestiveLivervacuolationhepatocyte
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DigestiveGallbladderarteritis
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DigestiveGallbladdercalculus
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DigestiveGallbladderhemorrhage
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DigestiveGallbladderhyperplasia
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DigestiveGallbladderhyperplasia, cystic mucinous
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DigestiveGallbladderinfiltrate, + cell type(s)mononuclear cell; lymphocyte; neutrophil; eosinophil; mixed cell; etc.
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DigestiveGallbladdermucocele