ABCDEFGHIJKLMNOPQRSTUVWXYZAAABACADAEAFAGAH
1
ΠœΠ°Ρ€ΠΊΠ΅Ρ€
(Rus)
Marker
(Eng)
Marker's characteristicsAging Diagnostic ApproachΠœΠ°Ρ€ΠΊΠ΅Ρ€ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ Π² 1 ΠΏΠ°Π½Π΅Π»ΠΈ1ПояснСниС ΠΏΡ€ΠΎ βœ“: Π»ΠΈΠ±ΠΎ ΠΏΠΎΡ‚ΠΎΠΌΡƒ Ρ‡Ρ‚ΠΎ данная панСль β€” это подмноТСство Π΄Ρ€ΡƒΠ³ΠΎΠΉ ΠΏΠ°Π½Π΅Π»ΠΈ, ΠΊΠ°ΠΊ для ΠΏΠ°Π½Π΅Π»Π΅ΠΉ ВСраностики, Π³Π΄Π΅ "Ρ€Π°ΠΊ", "ΠΌΠΎΠ·Π³ ΠΈ дСпрСссия" ΠΈ "сСрдцС ΠΈ сосуды" β€” подмноТСства FULL, Π»ΠΈΠ±ΠΎ панСль Π½Π΅ Π²Ρ‹Π·Ρ‹Π²Π°Π΅Ρ‚ ΠΏΠΎΠΊΠ° Π΄ΠΎΠ²Π΅Ρ€ΠΈΠ΅, ΠΊΠ°ΠΊ панСль Π² КИ GDF11.
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What's that in general?Type of a markerSystem, organ, processWhich of the 9 Hallmarks of Aging it tracksCytokinePanel Inclusion rankingEpigeneticFrailty
Index
Singapore
Panel
Chinese
Panel
British
Panel
SENSSASPTAME
(by Nir Barzilai)
GDF11
"trial"
Open LongevityΠœΠ°Ρ€ΠΊΠ΅Ρ€ Π² 2 панСлях2
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Horvath Clock
(IEAA)
Hannum
Clock
DNAm
PhenoAge
OL 1.4Theranostic 1.1ΠœΠ°Ρ€ΠΊΠ΅Ρ€ Π² 3 панСлях3
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https://habr.com/ru/post/428377/https://habr.com/ru/post/419721/https://habr.com/ru/post/420259/https://habr.com/ru/post/424399/https://habr.com/ru/post/423979/https://habr.com/ru/post/421225/https://www.ncbi.nlm.nih.gov/pubmed/19053174https://gdf11rejuvenation.com/doctors-biomarkersBasicProNewFULLOncologyBrain & DepressionHeart & VesselsΠœΠ°Ρ€ΠΊΠ΅Ρ€ Π² 4 панСлях4
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https://habr.com/ru/post/421875/ΠœΠ°Ρ€ΠΊΠ΅Ρ€ Π² 5 панСлях5
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https://habr.com/ru/post/422125/ΠœΠ°Ρ€ΠΊΠ΅Ρ€ Π² 6 панСлях6
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https://habr.com/ru/post/419819/https://habr.com/ru/post/423009/https://gdf11rejuvenation.com/daily-trending-biomarkershttp://openlongevity.org/diagnosticsΠœΠ°Ρ€ΠΊΠ΅Ρ€ Π² 7 панСлях7
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/figure/F1/https://habr.com/en/post/427029/https://docs.google.com/spreadsheets/d/16oGboYHa7szNRtCs5ALVNWFBSAsUacKra9fBfKdByDE/edit#gid=0https://dnkom.ru/analizy-i-tseny/diagnostika-stareniya-open-longevity/teranostika-1-1-full/https://dnkom.ru/analizy-i-tseny/diagnostika-stareniya-open-longevity/teranostika-1-1-rak/https://dnkom.ru/analizy-i-tseny/diagnostika-stareniya-open-longevity/teranostika-1-1-mozg-i-depressiya/https://dnkom.ru/analizy-i-tseny/diagnostika-stareniya-open-longevity/teranostika-1-1-serdtse-i-sosudy/ΠœΠ°Ρ€ΠΊΠ΅Ρ€ просто Π΅ΡΡ‚ΡŒ Π² ΠΏΠ°Π½Π΅Π»ΠΈ, панСль Π½Π΅ учитываСтся Π² ΠΏΠΎΠ΄ΡΡ‡Ρ‘Ρ‚Π΅βœ“
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Total number of markers in a panel β€”>353719412636563227102141491451192528
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Ѐосфорилированный гистон Ξ³H2AXPhosphorylated Histone Ξ³H2AXMolecularDNA222
11
Π”Π»ΠΈΠ½Π° Ρ‚Π΅Π»ΠΎΠΌΠ΅Ρ€Telomere lengthMolecularDNA11
12
Π”Π»ΠΈΠ½Π° Ρ‚Π΅Π»ΠΎΠΌΠ΅Ρ€ Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚ΠΎΠ²Leukocyte telomere lengthMolecularDNA11
13
ΠœΠ΅Ρ‚ΠΈΠ»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Π”ΠΠšDNA methylationMolecularDNA3353 CpG сайта мСтиллирования Π”ΠΠš71 CpG сайт мСтиллирования Π”ΠΠš3
14
ВнСклСточная Ρ†ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰Π°Ρ Π”ΠΠš (Π²ΠΊΠ”ΠΠš)Π‘ell-free DNA (also known as circulating DNA)MolecularDNA11
15
Π€Π΅Π½ΠΎΡ‚ΠΈΠΏ Π’-ΠΊΠ»Π΅Ρ‚ΠΎΠΊT cell phenotypeMolecularRNAi transcription11
16
Π“Π΅Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΡΡ‚ΡŒ CD38 Π² CD4 +CD27 + Π’-ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ…CD38 heterogeneity in CD4 + CD27 + T cellsMolecularRNAi transcription11
17
Π“Π΅Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΡΡ‚ΡŒ CD197 Π² CD4 +CD25 + T-ΠΊΠ»Π΅Ρ‚ΠΊΠ°Ρ…CD197 heterogeneity in CD4 + CD25 + T cellsMolecularRNAi transcription11
18
Π¦ΠΈΡ€ΠΊΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ ΠΌΠΈΠΊΡ€ΠΎΠ ΠΠš (miR-34a, miR-21, miR-126-3p, miR-151a-3p, miR-181a-5p, miR-1248)Circulating miRNAs (miR-34a, miR-21, miR-126-3p, miR-151a-3p, miR-181a-5p, miR-1248)MolecularRNAi transcription222
19
Π”Π»ΠΈΠ½Π½Ρ‹Π΅ Π½Π΅ΠΊΠΎΠ΄ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ РНК (MIR31HG, AK156230, Meg3)Long non-coding RNA (MIR31HG, AK156230, Meg3)MolecularRNAi transcription11
20
Π“ΠΎΡ€ΠΌΠΎΠ½ роста Growth factor (GF)MolecularMetabolism 3333
21
KlothoKlothoMolecularMetabolism 11βœ“
22
Π€Π°ΠΊΡ‚ΠΎΡ€ роста фибробластов 21Fibroblast growth factor 21 (FGF21)MolecularMetabolism 11
23
РСзистинResistin (RETN)MolecularMetabolism 222
24
АдипонСктин Adiponectin (ADIPOQ)MolecularMetabolism 222
25
mTORmTORMolecularMetabolism 222
26
pS6RPpS6RPMolecularMetabolism 11
27
NAD +, SIRT1, SIRT2, SIRT3, SIRT6NAD +, SIRT1, SIRT2, SIRT3, SIRT6MolecularMetabolism 11
28
ΠšΠ°Ρ€Π±Π°ΠΌΠΈΠ»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ²Protein carbamylationMolecularMetabolism 11
29
ΠšΠŸΠ“ ΠΈ N-Π³Π»ΠΈΠΊΠ°Π½Ρ‹Glycation end products and N-glycansMolecularMetabolism 11
30
Π“Π»ΠΈΠΊΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΉ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Glycosylated hemoglobin (HbAΠ‘1)MolecularGlucose metabolism333βœ“βœ“βœ“3βœ“βœ“
31
Π“Π»ΡŽΠΊΠΎΠ·Π°GlucoseMolecularGlucose metabolism222
32
Π“Π»ΡŽΠΊΠΎΠ·Π° Π½Π°Ρ‚ΠΎΡ‰Π°ΠΊFasting plasma glucoseMolecularGlucose metabolism22βœ“βœ“βœ“2βœ“βœ“βœ“
33
Π˜Π½ΡΡƒΠ»ΠΈΠ½InsulinMolecularGlucose metabolism333βœ“βœ“βœ“3βœ“βœ“βœ“
34
БиохимичСскиС ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈBiochemistry assayMolecularGlucose metabolism11
35
S100 ΠΊΠ°Π»ΡŒΡ†ΠΈΠΉ-ΡΠ²ΡΠ·Ρ‹Π²Π°ΡŽΡ‰ΠΈΠΉ Π±Π΅Π»ΠΎΠΊ BS100 calcium binding protein B (S100B)MolecularCalcium homeostasis11
36
Π Π΅Π³ΡƒΠΊΠ°Π»ΡŒΡ†ΠΈΠ½ (ΠœΠ°Ρ€ΠΊΠ΅Ρ€ старСния protein-30)Regucalcin (RGN)
(Senescence marker protein-30, SMP30)
MolecularCalcium homeostasis11
37
ΠšΠ°Π»ΡŒΡ€Π΅Ρ‚ΠΈΠΊΡƒΠ»ΠΈΠ½Calreticulin (CALR)MolecularCalcium homeostasis11
38
ΠΎ-Ρ‚ΠΈΡ€ΠΎΠ·ΠΈΠ½o-tyrosineMolecularOxidative stress, mitochondria and apoptosis222
39
3-Ρ…Π»ΠΎΡ€Ρ‚ΠΈΡ€ΠΎΠ·ΠΈΠ½3-chlorothyrosineMolecularOxidative stress, mitochondria and apoptosis222
40
3-Π½ΠΈΡ‚Ρ€ΠΎΡ‚ΠΈΡ€ΠΎΠ·ΠΈΠ½3-nitrotyrosineMolecularOxidative stress, mitochondria and apoptosis222
41
8-изопростан8-isoprostane (8-ISO)MolecularOxidative stress, mitochondria and apoptosis3333
42
8-гидрокси-2'-дСзоксигуанозин8-OHdGMolecularOxidative stress, mitochondria and apoptosis222
43
8-гидроксигуанозин8-OHGMolecularOxidative stress, mitochondria and apoptosis222
44
Π˜Ρ€ΠΈΠ·ΠΈΠ½Fibronectin type III domain containing 5 (FNDC5) (Irisin)MolecularOxidative stress, mitochondria and apoptosis11
45
Π’ΠΈΠΌΠ΅Π½Ρ‚ΠΈΠ½Vimentin (VIM)MolecularOxidative stress, mitochondria and apoptosis11
46
ΠœΠ°Π»ΠΎΠ½ΠΎΠ²Ρ‹ΠΉ диальдСгидMalonic dialdehydeMolecularOxidative stress, mitochondria and apoptosis11
47
ΠŸΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ‹ окислСния Π±Π΅Π»ΠΊΠΎΠ²Protein Oxidation Products (AOPP)MolecularOxidative stress, mitochondria and apoptosis11
48
ΠšΠ»Π΅Ρ‚ΠΎΡ‡Π½Π°Ρ ΠΌΡ‚Π”ΠΠš (Π΅Ρ‘ количСство ΠΈ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ ΠΌΡƒΡ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ΠΎΠ² с дСлСциями)Cellular mtDNA (its number and the presence of mutated variants with deletions)MolecularOxidative stress, mitochondria and apoptosis11
49
Π“Π»ΡƒΡ‚Π°Ρ‚ΠΈΠΎΠ½GlutathioneMolecularOxidative stress, mitochondria and apoptosis11
50
ЦистСинCysteineMolecularOxidative stress, mitochondria and apoptosis11
51
ΠœΠΎΡ‡Π΅Π²Π°Ρ кислотаUric acidMolecularOxidative stress, mitochondria and apoptosis22βœ“βœ“2βœ“
52
Π£Π±ΠΈΡ…ΠΈΠ½ΠΎΠ»UbiquinolMolecularOxidative stress, mitochondria and apoptosis11
53
ΠšΠ°Ρ€Π±ΠΎΠΊΡΠΈΠΌΠ΅Ρ‚ΠΈΠ»-Π»ΠΈΠ·ΠΈΠ½ (ΠšΠœΠ›)Carboxymethyl-lysine (CML)MolecularProtein glycation11βœ“
54
Π“Π»ΡŽΠΊΠΎΠ·Π΅ΠΏΠ°Π½GlucosepaneMolecularProtein glycation11
55
DOGDICDOGDICMolecularProtein glycation11
56
MODICMODICMolecularProtein glycation11
57
GODICGODICMolecularProtein glycation11
58
GOLDGOLDMolecularProtein glycation11
59
MOLDMOLDMolecularProtein glycation11
60
Амилоид Аβ-42Amyloid Aβ-42MolecularProtein aggregates11
61
ΠžΠ±Ρ‰ΠΈΠΉ Ο„-Π±Π΅Π»ΠΎΠΊTotal Ο„-proteinMolecularProtein aggregates11
62
Ѐосфорилированный Ο„-Π±Π΅Π»ΠΎΠΊPhosphorylated Ο„-proteinMolecularProtein aggregates11
63
Ассоциированная с ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ старСниСм Ξ²-Π³Π°Π»Π°ΠΊΡ‚ΠΎΠ·ΠΈΠ΄Π°Π·Π°Associated with cellular aging Ξ²-galactosidase (SA-Ξ²-Gal)MolecularCell senescence222
64
АссоциированныС с ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ старСниСм Π³Π΅Ρ‚Π΅Ρ€ΠΎΡ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΈΠ½ΠΎΠ²Ρ‹Π΅ фокусыHeterochromatin foci associated with cellular aging (SAHF)MolecularCell senescence11
65
Π‘Π΅Π»ΠΎΠΊ p16INK4Ap16INK4AMolecularCell senescence222
66
ЛипофусцинLipofuscinMolecularCell senescence11
67
Бвязанный со старСниСм сСкрСторный Ρ„Π΅Π½ΠΎΡ‚ΠΈΠΏSenescence associated secretory phenotype (SASP)MolecularInflammation and intercellular communication11
68
CD14 Π°Π½Ρ‚ΠΈΠ³Π΅Π½CD14 antigenMolecularInflammation and intercellular communication11
69
Π€Ρ€Π°ΠΊΡ‚Π°Π»ΠΊΠΈΠ½ CX3CL1Fractalquin (CX3CL1)MolecularInflammation and intercellular communication11
70
ΠŸΠ΅Π½Ρ‚Ρ€Π°ΠΊΡΠΈΠ½Pentraxin (PTX3)MolecularInflammation and intercellular communication11
71
ΠœΠΎΠ»Π΅ΠΊΡƒΠ»Ρ‹ Π°Π΄Π³Π΅Π·ΠΈΠΈ sVCAM/sICAMAdhesion molecules
sVCAM/sICAM
MolecularInflammation and intercellular communication222
72
Π˜Π½Ρ‚Π΅Ρ€Π»Π΅ΠΉΠΊΠΈΠ½ 6Interleukin 6 (IL-6)MolecularInflammation and intercellular communicationpro-inflammatory7777777βœ“βœ“7βœ“
73
Π˜Π½Ρ‚Π΅Ρ€Ρ„Π΅Ρ€ΠΎΠ½ Π³Π°ΠΌΠΌΠ° ΠΈΠ½Π΄ΡƒΡ†ΠΈΠ±Π΅Π»ΡŒΠ½Ρ‹ΠΉ Π±Π΅Π»ΠΎΠΊ (IP-10) (ΠΎΠ½ ΠΆΠ΅ CXCL10 C-X-C motif chemokine 10)Interferon gamma inducible protein IP-10 (also known as CXCL10 C-X-C motif chemokine 10)MolecularInflammation and intercellular communication222
74
Π’Ρ€Π°Π½ΡΡ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΉ ростовой Ρ„Π°ΠΊΡ‚ΠΎΡ€ Π±Π΅Ρ‚Π°Transforming growth factor-Ξ² (TGF-Ξ²)MolecularFibrosisanti-inflammatory222βœ“
75
Π˜Π½Π³ΠΈΠ±ΠΈΡ‚ΠΎΡ€ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ‚ΠΎΡ€Π° ΠΏΠ»Π°Π·ΠΌΠΈΠ½ΠΎΠ³Π΅Π½Π° 1Plasminogen activator inhibitor 1 (PAI-1)(also known as Serpine E1)MolecularFibrosis222
76
Π£Ρ€ΠΎΠΊΠΈΠ½Π°Π·Π½Ρ‹ΠΉ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ‚ΠΎΡ€ ΠΏΠ»Π°Π·ΠΌΠΈΠ½ΠΎΠ³Π΅Π½Π°Urokinase plasminogen activator (uPA)MolecularFibrosis222
77
Π’ΠΊΠ°Π½Π΅Π²Ρ‹ΠΉ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ‚ΠΎΡ€ ΠΏΠ»Π°Π·ΠΌΠΈΠ½ΠΎΠ³Π΅Π½Π°tPA11
78
ΠœΠ°Ρ‚Ρ€ΠΈΠΊΡΠ½Π°Ρ ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Π°-1Matrix metalloproteinases (MMP-1)11
79
ΠœΠ°Ρ‚Ρ€ΠΈΠΊΡΠ½Π°Ρ ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Π°-3Matrix metalloproteinases (MMP-3)11
80
ΠœΠ°Ρ‚Ρ€ΠΈΠ»ΠΈΠ·ΠΈΠ½, матриксная ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Π°-7Matrix metalloproteinases (MMP-7)MolecularFibrosis11
81
ΠœΠ°Ρ‚Ρ€ΠΈΠΊΡΠ½Π°Ρ ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Π°-9Matrix metalloproteinases (MMP-9)MolecularFibrosis1βœ“
82
ΠœΠ°Ρ‚Ρ€ΠΈΠΊΡΠ½Π°Ρ ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Π°-10Matrix metalloproteinases (MMP-10)11
83
Π’Ρ€Π°Π½ΡΠ³Π»ΡŽΡ‚Π°ΠΌΠΈΠ½Π°Π·Π° 2 Transglutaminase 2
(TGM2)
MolecularFibrosis11
84
Вромбоспондин-2Thrombospondin-2
(THBS2)
MolecularFibrosis11
85
АнгиотСнзиногСнAngiotensinogen (AGT)MolecularFibrosis11
86
НСйротрофичСский Ρ„Π°ΠΊΡ‚ΠΎΡ€ ΠΌΠΎΠ·Π³Π° Brain neurotrophic factor
(BDNF)
MolecularNeurons and neuromuscular junction11
87
АгринAgrin (AGRN)MolecularNeurons and neuromuscular junction11
88
ΠŸΡ€ΠΎΠ³Ρ€Π°Π½ΡƒΠ»ΠΈΠ½Progranulin (PGRN)MolecularNeurons and neuromuscular junction11
89
ΠšΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΌΠ΅Π½Ρ‚Π° C3 ΠΈ C1qComplement factor 3 and 1Q (C3 ΠΈ C1q) MolecularNeurons and neuromuscular junction11
90
Π Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€ AGERAdvanced glycosylation end-product specific receptor (AGER)MolecularNeurons and neuromuscular junction11
91
Π‘Π΅Π»ΠΎΠΊ HMGB1 (high mobility group box 1)High mobility group box 1 (HMGB1)MolecularNeurons and neuromuscular junction222
92
Растворимый супрСссор туморогСнности ST2Soluble suppression of tumorigenicity 2 (ST2) MolecularNeurons and neuromuscular junction11
93
Π˜Π½Ρ‚Π΅Ρ€Π»Π΅ΠΉΠΊΠΈΠ½-8 Interleukin-8 (IL-8)MolecularAll-cause mortalitypro-inflammatory222
94
ΠžΡΡ‚Π΅ΠΎΠΏΡ€ΠΎΡ‚Π΅Π³Π΅Ρ€ΠΈΠ½ Osteoprotegerin
(OPG)
MolecularAll-cause mortality11
95
Π€Π°ΠΊΡ‚ΠΎΡ€ стволовых ΠΊΠ»Π΅Ρ‚ΠΎΠΊ Stem cell factor
(SCF)
MolecularAll-cause mortality11
96
Π“Π»ΡŽΠΊΠ°Π³ΠΎΠ½ΠΎΠΏΠΎΠ΄ΠΎΠ±Π½Ρ‹ΠΉ ΠΏΠ΅ΠΏΡ‚ΠΈΠ΄-1Glucagon-like peptide-1 (GLP-1)MolecularAll-cause mortality11
97
Π€Π°ΠΊΡ‚ΠΎ Π½Π΅ΠΊΡ€ΠΎΠ·Π° ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ЀНО-Ξ±Facto necrosis of tumors
(TNF-Ξ±-R)
MolecularAll-cause mortality222
98
ЭотаксинEotaxinMolecularAll-cause mortality11
99
Π₯Π΅ΠΌΠΎΠΊΠΈΠ½ IP-10Chemokine IP-10MolecularAll-cause mortality11
100
ΠšΠΎΠΆΠ½Ρ‹ΠΉ Ρ…Π΅ΠΌΠΎΠΊΠΈΠ½, ΠΏΡ€ΠΈΠ²Π»Π΅ΠΊΠ°ΡŽΡ‰ΠΈΠΉ Π’-ΠΊΠ»Π΅Ρ‚ΠΊΠΈ (CTACK)Cutaneous chemokine attracting T-cells (CTACK)MolecularAll-cause mortality11