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Drug Class/Type of Drug What does it do?Perscribed by who? Any side effects? Comments?
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fexafenodine hydrochloride (Allegra in the USA) Antihistaminecan help damped flare ups and lessen pain OTC drowsiness
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Hydroxyzine Antihistamine / Anti anxiety med commonly prescribed for ICOTC /Presciption possibly?Can cause drowsiness, dry mouth and blurred vision. Can also cause stomach problems and headaches. Long-term use potentially linked to an increased risk of dementia; as with other sedative antihistamines
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Azo OTC (Phenazopyridine Hydrochloride)
pain killer can help with pain and urgencyOTC turns pee bright orange correlated with cancer
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Pyridium (Phenazopyridine Hydrochloride)Prescription strength AZO - anelgesic Prescriptioncorrelated with cancer
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Estrogen Cream Prescription
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Gemtesa Overactive Bladder Drug Relaxes bladder muscles Prescriptionheadache, nausea, diarrhea, and an increased risk of infections.
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Oxybuntin Overactive Bladder Drug Prescription
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Valium suppositories pain relief calms/relaxes muscle more locally Prescriptioncan cause bacterial flora interuptions (yeast and BV infections)
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Solifenacin/VesicareOveractive Bladder Drug Prescription
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AmitryptylineAntidepressant PrescriptionCan cause or worsen urinary retention
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XanaflexMuscle relaxantCan relax musclesPrescriptionCan cause dizziness
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Semaglutide/Tirzeptide (GLP1s)Unsupported; might help with pain from inflammationPrescription
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Urogesic bluePrescription
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Elmiron (Pentosan Polysulfate Sodium,Repairs GAG layer PrescriptionNOT a first-line drug - eyesight/retina risk with long term use or at high doses
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Low Dose Naltrexone (LDN) Helps with immunity and reduces inflammation. Immune Modulation: By temporarily blocking opioid receptors, LDN may stimulate an increase in the body's production of endorphins, which are natural compounds that can influence mood and immune function. This process is believed to help balance the immune system.

Reduced Inflammation: LDN is thought to potentially reduce the activity of microglial cells in the central nervous system. These cells can contribute to inflammation, and suppressing their activity may help alleviate symptoms associated with conditions like fibromyalgia and multiple sclerosis.
I think you can get this OTC in USA; not sure in other countries.Has also been used to treats Chrones, Fibromylagia, etc.
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Urogesic blueCombo drug used to relieve the discomfort associated with urinary tract infections (UTIs) or certain medical procedures. It is a combination of four different medications that work together to treat symptoms like pain, burning, frequent urination, and bladder spasms.
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Hyoscyamine extended-release (ER)		Anti-spasmadic drug (can also be used for IBS and other GI tract issues) a medication used to control bladder spasms, which can help manage the urinary urgency and frequency associated with interstitial cystitis (IC). It is an antispasmodic medication that works by relaxing the bladder muscles. Prescription
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Supplement Name What does it do/help with?BrandDosageComments
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Vitamin B12 There is some research that shows that vitamin b12 definciency is correlated to flares. B12 is directly correlated with nerve health and signaling to the bladder. Some though report that it can make pain worse so proceed with caution. Lots of different ones; both in liquid (faster to digest) and pill form. NOTE: B6 has been associated with CAUSING FLARES so make sure you're testing out B12!
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Pumpkin Seed Oil Bladder Muscle Support: Pumpkin seed extract is believed to strengthen the pelvic floor muscles and help relax the bladder muscles. This can increase bladder capacity, reduce urinary frequency, and lessen the urgency to urinate.

Hormonal Influence: The extract contains compounds called phytosterols, which may help with hormonal balance. Some studies suggest this can contribute to bladder and prostate health, particularly by inhibiting an enzyme that affects hormone metabolism.

Nutrient-Rich Profile: Pumpkin seeds are packed with nutrients that benefit overall health. They are a rich source of magnesium, which is important for muscle function and relaxation. They also contain essential fatty acids (like omega-6 and omega-9), antioxidants, and zinc, which contribute to heart health, inflammation reduction, and immune system support		Coats/helps bladder for pain management
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Aloe SupplementsCoats bladder to prevent further irritation of the bladder walls analgesic effects https://desertharvest.com/pages/desert-harvest-aloe-vera-for-ic-bps?srsltid=AfmBOorRIR27Dq_U-8Mxm046Ef0L0jqy1BMvoAFLYkbMGrY5FUb5Cd4mAloe FULL LEAF contains yellow latex, or "aloin," which is toxic. It has laxative effects, is a possible carcinogen along with general toxicity. Processed Inner Leaf does not contain latex, but as with all supplements this is not well regulated.
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Marshmellow Leaf Extract Tea/Marshmallow Root Tea analgesic effects
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Krill oil?
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High allicin garlic extract
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Peaora PEA-500Reveratrol + Magnesium + D3 anti-inflammatory and analgesic effectshttps://www.icnetwork.org/pea-reduces-pelvic-pain-in-ic-vulvodynia-endometriosis-prostatitis-now-menstrual-cramping/"Sadly enough, since 2012 a number of clinically untested PEA
formulations flooded the market,[..] It is therefore important to point out that
only PEA formulations containing sufficiently ultrafine particles have
been tested sufficiently. Only such formulations are proven to lead to increased plasma levels of PEA after intake. Such micro PEA formulations are known under the names micronized PEA (PEA-m), ultra micronized PEA (PEA-um) and optimized PEA (PEA-opt)." - Article, 2018
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Glucosamine
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Licorice Root TeaPresent in Throat Coat- can act as a laxative
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Slippery Elm Bark teaPresent in Throat Coat
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Psyllium husk (dissolve in water)
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QuercetinSupplement/present in pigmentation of many fruits and berries; blueberries, raspberries, strawberries, etc.Can cause organ damage as a supplement
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What does it do/help with?
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Muscle relaxants
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Tens device Pain relief https://www.taphealth.nz/product-page/tap-2-0
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Warm baths Pain relief
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Heating pads for sleep Pain relief
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Elevating your pelvis Pain relief
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PT Pelvic FloorPain relief
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CBD gummies/oil Pain relief
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Hydrodistention Hydrodistention is a medical procedure that involves filling the bladder with fluid to stretch it and examine its capacity and function. Pain relief
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Bicarbinate with soda teaspoon with water suggested for pain relief Pain relief
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Botox in your bladder Pain relief
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Pelvic Wands do help with DIY pelvic floor therapyPain relief https://www.intimaterose.com/collections/pelvic-wands
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Red light Therapy
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SSRIs/Antidepressants
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Venlafaxine/EffexorIt is a serotonin and norepinephrine reuptake inhibitor (SNRI) that treats depression, anxiety, and panic disorders.
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AmitriptylineAmitriptyline is a tricyclic antidepressant medication used to treat depression, nerve pain, and to prevent migraines
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Hydroxyzine Antihistamine / Anti anxiety med commonly prescribed for ICCan cause drowsiness. Long-term use potentially linked to an increased risk of dementia; as with other sedative antihistamines
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Nortriptyline (Pamelor and Aventyl)
Antidepressant Nortriptyline is a tricyclic antidepressant (TCA) used to treat depression, and is also prescribed off-label for a variety of other conditions, including certain types of chronic painPrescription
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