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Article TitleAuthorPublishing DateKey WordsJournal TitleISSNOnline ISSNVolumeIssueLink to Full-Text Articles (PDF)AbstractDOILink to AbstractPublisherReference
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1A Bird's Eye View of the Novel Coronavirus Pandemic. Sandeep Asthana2020.06Coronavirus, SARS-CoV-2, COVID-19
Journal of ALLBIOSOLUTION
2605-35352605-353521World is witnessing the pandemic of a RNA virus SARS-CoV-2 (severe acute
respiratory syndrome coronavirus-2) as it is named by the WHO on February
11, 2020. The syndrome is named COVID-19 (corona virus disease 2019). This
pandemic has led to health, social and economic problems including economic
slowdown, loss of life, unemployment, psychological problems, and stress.
SARS-CoV-2 is believed to have originated in Wuhan province of China. Initially
it was thought to be an animal to human transmission. But posterior the WHO
(World Health Organization) declared its spread from human to human, creating
a huge problem in Wuhan and Hubei province of China. It came from the wet
market of China from bats to humans. From there, it spread over 190 countries
across the globe.		https://www.allbiosolution.com/2020/06/a-birds-eye-view-of-novel-coronavirus.htmlAllbiosolution



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2Sighting Common Snapping Turtle Chelydra serpentina (Linnaeus, 1758) at Silver Spring, Maryland (USA) and its account with other aspects Akhlaq Husain2021.01Sighting Snapping Turtle at Silver Spring, MarylandJournal of ALLBIOSOLUTION2605-35352605-353531Present communication deals with the sighting of Chelydra serpentina, the Common Snapping Turtle at Silver Spring, Maryland (USA) and reported here for the record. Its synonymy, diagnostic features, distribution, food & feeding, breeding, nesting migration, behaviour, conservation status, threats and control measures have been provided. Variations in length of carapace and plastron, body weight and maturity-size as per various records have also been given.https://www.allbiosolution.com/2020/05/sighting-common-snapping-turtle.htmlAllbiosolution
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3Influence of Sunlight on the Cyanobacterial Diversity of Rice Fields Rishi Kumar Sharma, Shatrughna Singh2021.06Cyanobacteria, Rice fields, SunlightJournal of ALLBIOSOLUTION2605-35352605-353531In the tropical paddy fields, numerous prevailing conditions and factors i.e., either natural or man-made, apparently influence the cyanobacterial diversity. On the basis of study on different rice cultivation sites around the Varanasi district of Uttar Pradesh (India), it had been observed that the gradually increasing dense canopy of rice plants resulted in the death of already flourishing filamentous green algal mat and favored the growth of various cyanobacterial forms. In most of the rice fields, the maximum diversity of cyanobacteria was during the vegetative growth phase and grain filling phase of rice cultivation, when maximum shade had been provided by the rice plant. In most of the rice fields around the last phase of rice cultivation, when the soil became fully exposed to solar light, the brownish coloured papery layer of Aulosira sp. had been observed on the soil as well as attached to the remaining stumps of the rice plants but the cyanobacteria was in the sporulation phase. However, an appreciable number of Nostoc, Cylindrospermum, Microcoleus and Chroococcus sp. had been observed from the fully exposed and illuminated portion of rice fields and its cultivation cycle. Most of the cyanobacterial forms collected from the fully exposed portions of rice fields to sunlight, developed larger amounts of bright/ dark coloured mucilage or exopolysaccharide compared to most of the other forms that grew in the shelter of paddy. The present communication is related to the study of local cyanobacterial diversity along with its interaction with the light regime that can be useful for the efficient algalization.https://www.allbiosolution.com/2020/09/influence-of-sunlight-on-cyanobacterial.htmlAllbiosolution
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4Bioactive compounds of Allium sativum (Garlic) & their pharmacological propertiesAlok Tripathi, Surabhi Singhal, Navneet Sharma2021.09Garlic, Allium Sativum, Antioxidant, Anti-inflammatory, AnticancerJournal of ALLBIOSOLUTION2605-35352605-353531Allium sativum (Garlic) is considered as most significant herbs that have been used as traditional medicine from very old times. From ancient to current time different studies have confirmed the significant biological activities of garlic which includes anti-infectious properties, anti-inflammatory, antioxidant, anti-obesity, cardiovascular protective, anti-diabetic, free radical scavenging and anticancer properties.

Allium sativum has a diverse range of bioactive compounds and these are mainly organosulfur compounds, phenolic compounds and saponins. Primarily dominating phytochemicals are sulfur-containing compounds which are Alliin (C6H11NO3S), Allicin (C6H10OS2), E-Ajoene (C9H14OS3), Z-Ajoene (C9H14OS3), 2-Vinyl-4H-1,3-dithiin (C6H8S2), Diallyl sulfide (C6H10S), Diallyl disulfide (C6H10S2), Diallyl trisulfide (C6H10S3), Allyl methyl sulfide (C4H8S). It’s found that bioavailability of capsule prepared by garlic powder is in the range of 26-109 % while bioavailability of non enteric tablets is in the range of 80-111 %. It shows that bioavailability of tablets are more in comparison to capsule of garlic powder

Current review discusses the chemical bioactive compound compositions of the Allium sativum (Garlic) and its pharmacological properties, which prove the importance of garlic in the cure of different types of diseases.		https://www.allbiosolution.com/2021/04/bioactive-compounds-of-allium-sativum.htmlAllbiosolution
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5The need for the MDR (Medical Device Regulation) J. Carlos Pastor 2021.12Medical Device Regulation, MDRJournal of ALLBIOSOLUTION2605-35352605-353531It is obvious that the new regulation, Regulation (EU) 2017/745 named Medical Device Regulation or simply MDR (1) of the European Commission, represents a serious problem for many companies manufacturing medical devices that will have to adapt their productive systems, and especially their safety control, monitoring follow-up and notification of possible adverse effects in a very different manner.

The MDR is going to involve a series of very important changes, with the ultimate goal of ensuring that when a product with the CE marking is used, patients and doctors can have sufficient guarantees that the product is safe.

I do not know what has happened in other fields of medicine, but in the specific aspect of medical devices used in intraocular surgery, the behavior of many companies in recent years has been a complete scandal, producing hundreds, probably thousands of blind people worldwide and creating a terrible feeling of insecurity into the eye surgeons.		https://www.allbiosolution.com/2021/12/the-need-for-mdr-medical-device.htmlAllbiosolution
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6Levels of heavy metals in uncontrolled agricultural farms compared to regulated organic farms Jessica Briffa, Renald Blundell,Emmanuel Sinagra, Joseph Grech2022.01Agricultural land, organic farms, XRF, heavy metals, pollution, environment, soilJournal of ALLBIOSOLUTION2605-35352605-353541Over the last few years, soil pollution was observed to have increased rapidly, mostly due to anthropogenic sources. Heavy metal pollution has been seen to enter the food chain which has caused great concern due to the adverse affect to the health of the public wellbeing. Anthropogenic activities include livestock and agriculture soil pollution; sewage, waste production and disposal; infrastructure, transportation and urbinanisation; industrial activity; fireworks; mining and warfare. Conventional farmers use a number of pesticides and fertilizers containing heavy metals which unfortunately remain in the soils and water table, and eventually end up in the crops and food chain. The aim of the study was to evaluate the difference between the amount of heavy metals present in conventional and organic farms and to observe if there is a significant difference between the two types of farming.

One hundred and one samples from around Malta and Gozo in 2019 were compared to two organic certified farms which confirmed through binomial testing that all ρ-values from the 101 samples compared with both controls, were less than the 0.05 level of significance stating that the district score differs significantly from the control value. Results showed that heavy metals where mostly found in the South-Eastern and South Harbour district. In the South-Eastern district, heavy metals found were vanadium at 64.25 mg/kg, manganese at 586.67 mg/kg, chromium at 45.93 mg/kg, selenium at 15.51 mg/kg and nickel at 21.90 mg/kg. In the Southern Harbour district, the heavy metals present were lead at 249.51 mg/kg, zinc at 251.33 mg/kg and copper at 95.15 mg/kg. The Northern district contained high concentrations of the heavy metals molybdenum at 12.09 mg/kg and arsenic at 7.93 mg/kg. In the Northern Harbour there is a high concentration of cadmium at 30.10 mg/kg. Cobalt was found highest in the Gozo and Comino district with a concentration of 15.8 mg/kg. The Finland standards were used to compare the results. Lead, cadmium, arsenic and zinc were to be found at high concentrations then the Finland standards, where the standards were at 60 mg/kg, 1 mg/kg, 5 mg/kg and 200 mg/kg respectively. Organic agricultural land proved to have lower concentrations of heavy metals than conventional agricultural land, which may be attributed to the lack of pesticide and chemical use.		https://www.allbiosolution.com/2021/07/heavy-metals-in-uncontrolled.htmlAllbiosolution
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7Applications of Palynology in Forensic Investigations: A Systematic ReviewOm Kishor Singh2022.06Botany, Molecular Biology, Forensics, Pollen, PalynologyJournal of ALLBIOSOLUTION2605-35352605-353541Forensic science, a multidisciplinary subject, encompasses the knowledge of physics, chemistry, geology, computer science, medical science, botany, zoology and molecular biology. Forensics is constantly renewed by adopting latest methods, procedures and techniques for solving legal issues. The study of pollen is one of the novel approaches of this aspect of science. This overview describes the significance of palynology, its applications, and different recent approaches and how it could be employed in solving criminal investigations.https://www.allbiosolution.com/2022/04/applications-of-palynology-in-forensic.htmlAllbiosolution
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8Study Of Physico-Chemical Parameters And Assessment Of Groundwater Quality Near Tamsa River In Azamgarh District (U.P)Prem Yadav, Rajesh Kumar Yadav2022.01Contamination, Electrical Conductivity, Ground Water, Hard water, Total Dissolve Salt Journal of ALLBIOSOLUTION2605-35352605-353541Earth's surface contains different types of ores, salts and minerals which water dissolves to increase salinity of groundwater. By the river, rain and other sources of water, the salts present on the surface meet in the groundwater and change their concentration. Salinity is caused as a result of dissolution of minerals like halite, anhydrite, carbonates, gypsum, fluoride-salts and sulphate salts. The physico- chemical analysis of sample number S-1 to S-10 is colorless, odorless and without turbidity in summer and rainy season except sample S-3. This indicates that salt concentration in ground water is low, but sample S-3 in turbid and colour change on exposure in air after some time indicate that salt concentration and dissolved salt or metal ion concentration is high in the area of Gopalganj, Azamgarh. The P H = 6.96, TDS= 1200ppt and electrical conductivity is 2260 Ms -1 indicate that water in this area is moderately hard and dissolution of minerals during water percolation in the rainy season becomes high. https://www.allbiosolution.com/2022/06/STUDY%20OF%20PHYSICO-CHEMICAL%20PARAMETERS%20AND%20ASSESSMENT%20OF%20GROUNDWATER%20QUALITY%20NEAR%20TAMSA%20RIVER%20IN%20AZAMGARH%20DISTRICT%20U.P.htmlAllbiosolution
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9Abstracts of the Papers Presented in the International Symposium on Safety Assessment under Materiovigilance and Pharmacovigilance Programs, on 20 May, 2022. India, Spain and Malaysia. Girish K. Srivastava, V Kalaiselvan, R Mathur, P Raina, Sweety,D Kumar, RK Goyal,Anoop Kumar,Nath Madhu, Prasad Hanuman Sharma, Sural Sumit, A Goel,A Mohan, G Aishwarya, A Sharma, S Sural, AA Kumar, Chand Neha,Dwivedi Shridhar, Javed Faiza,Rohit Saxena,J.C. Pastor, Raghuvanshi Rajeev Singh 2022.08Safety Assessment, Materiovigilance, Pharmacovigilance Journal of ALLBIOSOLUTION2605-35352605-353541Abstracts of the Papers Presented in the International Symposium on Safety Assessment under Materiovigilance and Pharmacovigilance Programs, on 20 May, 2022 organized by
-Delhi Pharmaceuticals Sciences & Research University, Govt of NCT of Delhi, INDIA,
-Indian Pharmacopoeia Commission, MoHFW, Govt of India, INDIA,
-University of Valladolid, Valladolid, SPAIN,
-University College Sedaya International, KL, MALAYSIA		https://www.allbiosolution.com/p/volume-4-issue-1.htmlAllbiosolution
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10Overview of Materiovigilance program of Govt. of INDIAV. Kalaiselvan2022.08Materiovigilance program Journal of ALLBIOSOLUTION2605-35352605-353541The Materiovigilance programme of India (MvPI), launched by the Ministry of Health & Family Welfare, Government of India; the Indian Pharmacopoeia Commission (IPC)mandated with the responsibilities to coordinate as National Coordination Centre (NCC). The MvPI aims to collect, collate and analyze the adverse events associated with the use of medical devices and communicate the safety outcomes to healthcare professionals and Central Drugs Standard Control Organization (CDSCO). The IPC as NCC plays a crucial role in establishing the programme by recognizing Medical Devices Adverse Events monitoring centres (as a dynamic process), providing training to the stakeholders, effectively coordinating with CDSCO and state drug control authorities for effective implementation of MvPI. The culture of suspected adverse events of medical devices reporting among the healthcare providers in India is increasing year by year. The reported adverse events are regularly analyzed and findings have been communicated to the stakeholders. The IPC is committed to promote the MvPI starting from primary health care. Also IPC is working towards establishing a network of academic and research institutes as well to understand the devices related issues through research based approach.https://www.allbiosolution.com/2022/06/Overview%20of%20Materiovigilance%20program%20of%20Govt.%20of%20INDIA.htmlAllbiosolution
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11Systematic review and meta-analysis of adverse effects associated with monoclonal antibodies used in different inflammatory conditions and breast cancerMathur R, Raina P, Sweety, Kumar D, Goyal RK2022.08Meta-analysis, monoclonal antibodies, breast cancerJournal of ALLBIOSOLUTION2605-35352605-353541During the COVID-19 pandemic, the clinical management of patients with long- standing disorders of immune system, as in autoimmune and inflammatory conditions (rheumatoid arthritis(RA), multiple sclerosis(MS)) or consequence of cancer chemotherapy (immunosuppression in breast cancer(BC)) has been fraught with challenges. First, when compared to the general population, these patients have a higher risk of COVID-19 infection, second, the outcomes are worsened by COVID-19 infection and third, during lockdowns, these patients experienced increased pain and functional impairment that severely affected the quality of life (QoL) and mental health. The use of monoclonal antibodies (mAbs) have become the mainstay for the treatment of these indications, but they are associated with various adverse events (AEs), regarding which there is paucity of data. In order to aid in rational treatment choices, the safety profile of mAbs, each approved for the treatment of RA (Sarilumab, Tocilizumab, Adalimumab, Golimumab, Infliximab, Rituximab), MS (Natalizumab, Ocrelizumab, Alemtuzumab) and BC (trastuzumab) was statistically compared. In accordance with the PRISMA statement, the systematic literature review was conducted using databases such as PubMed, Cochrane library and Science Direct. The primary outcome was the occurrence of AEs with the use of approved mAbs and the data was synthesized using GraphPad Prism and Medcalc. The safety of three monoclonal antibodies—natalizumab (NTZ), ocrelizumab (OCR), and alemtuzumab (ALM), used for the treatment of both relapsing and progressive forms of multiple sclerosis (MS) was reviewed from clinical studies published between 2016 and 2020 in the PubMed database. The most common AEs associated with the use of NTZ, OCR, and ALM were infection (UTI, RTI) and infestation. The use of ALM was associated with immune thrombocytopenia (2%), respiratory infections (7%), and thyroid dysfunction (43%), making the use of NTZ and OCR a safer choice for MS. In RA, the highest and lowest percentage of AEs were recorded with Golimumab and Rituximab, respectively. In patients treated for BC, the AEs such as myalgia, nasopharyngitis, hypertension, and reduced ejection fraction were commonest with Trastuzumab biosimilar.
https://www.allbiosolution.com/2022/06/Systematic%20review%20and%20meta-analysis%20of%20adverse%20effects%20associated%20with%20monoclonal%20antibodies%20used%20in%20different%20inflammatory%20conditions%20and%20breast%20cancer.htmlAllbiosolution
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12Risks and Benefit Analysis of MedicationsKumar Anoop 2022.08DrugsJournal of ALLBIOSOLUTION2605-35352605-353541Risk and benefit ratio of drugs from clinical trials determines whether a candidate drug is suitable for marketing. The regulatory authority authorized the product if the benefits outweigh the risks. This balance might be change later once drug reach into the market as a result of exposure in a large number of patients, concomitant medications and diseases, long-term exposure, confounding factors, and so on. For example, benefit might be 90% and risk 10% when the first periodic safety update report (PSUR) is submitted. These percentages might have changed when the fifth PSUR is submitted (benefit 60% and risk 40%). Therefore, periodic re-examination of the risk and benefit profile of medications is required to ensure that the balance remains favourable. The talk is started with basics of risks and benefit profile of medications. Further, key findings of completed work at DPSRU i.e., “identification of novel signal of clindamycin associated acute renal failure and identification of novel signals of proton pump inhibitors (PPIs) on renal system” are also presented. The ongoing work i.e., identification of novel signal and prediction of mechanism of ADRs using Network Pharmacological approaches in Department of Clinical Research at DPSRU is also highlighted. https://www.allbiosolution.com/2022/06/Risks%20and%20Benefit%20Analysis%20of%20Medications.htmlAllbiosolution
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13A systematic review on research documentation of ocular medical device focused on Perfluorocarbon Liquid (PFCL)V. Kalaiselvan, Shatrunajay Shukla, Nikita Mishra, Shubhang Arora, Yash Kumar Vimal, Rajeev Singh Raghuvanshi2023.01Medical device, regulation, PFCL toxicity, adverse eventJournal of ALLBIOSOLUTION
2605-35352605-353551Medical devices are using worldwide and has a good annual consumption on ocular medical devices. Medical devices are being used in healthcare domain for diagnosis, monitoring, prevention and treatment of an array of diseases. The use of medical devices benefits the patients immensely, but they also carry significant risk potential. Recently, countries like- Spain, Holland, France, Italy, Middle East, Switzerland and Chile have reported several cases of acute retinal toxicity due to perfluorocarbon liquids (PFCL), especially perfluoro-octane (PFO). These reported cases cause a panic situation among healthcare practitioners such as doctors, nurses, technicians, biomedical engineers and medical device stakeholders. So, regulation & scientific publications of these medical devices across globe are the need of an hour. Method: Global regulation on PFCL were thoroughly studied and analysed. The web of science-based search was performed on scientific publications available worldwide. Conclusion: This paper reviews the global regulation & scientific publications on PFCL and provides an idea about the need of further improvement.https://www.allbiosolution.com/2022/11/a-systematic-review-on-research.htmlAllbiosolution
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14Nutrition Rich Fruits and Vegetables: Status and Opportunities in the Era of Genome EditingSuhas Gorakh Karkute, Kishor Uttamrao Tribhuvan, Shruti Yadav2023.03Nutrition, CRISPR/Cas9, fruits, vegetables, genome editingJournal of ALLBIOSOLUTION2605-35352605-353551Improvement of nutrition in fruits and vegetables is one of the most important aspects of plant breeding programmes. Biofortification of food crops is necessary to alleviate the challenges of hidden hunger. Consumption of fruits and vegetables provide nutrients like vitamins, minerals, dietary fibres, antioxidants to some extent, however, they either lack or have insufficient amount of several nutrients essential for human health. Recently developed genome editing tools like CRISPR/Cas9 have been successfully utilized for improving the nutrient content of various vegetables and fruits. Considering the potential of the genome editing technique, it is possible to enhance the nutrients as well as to synthesize novel health promoting compounds in the fruits or vegetables by metabolic engineering. This article describes the status and opportunities of improving the nutrition of fruits and vegetables using genome editing approaches.https://www.allbiosolution.com/2022/11/nutrition-rich-fruits-and-vegetables.htmlAllbiosolution
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15A Rare Atypical Mycobacterial Infection After Face Lifting Thread Implant: A Case Study In New Delhi, India. V. Kalaiselvan, Nikita Mishra, Shatrunajay Shukla, Mita Nandy, Shubhang Arora, Rajeev Singh Raghuvanshi2023.09Definisse thread, mycobacterial infection, adverse event, surgeryJournal of ALLBIOSOLUTION2605-35352605-353551Background: Infection is a common complication after the thread-lifting procedure, but mycobacterial infection after thread-lifting procedure is quite rare. Objective: To study the prevalence of adverse events during eight weeks after thread implant. Patients/Methods: A 63-year-old woman undergone face lift definisse thread implantation at cosmetic studio in India. After implantation, patient felt boils on her face and immediately consulted doctor. A surgical pathology report of patient confirmed atypical mycobacterial infection as clinical diagnosis. Consequently, patient is under antibiotics treatment. Result: Facial rejuvenation techniques with thread lifting have gained popularity. Atypical mycobacterial infection with the thread lifting procedure is considered as rare adverse event. Currently, the patient is in recovering stage. Conclusion: Face-lifting surgery is not completely safe procedure for the patients. Presented case study with the experience of the patient should be taken as a guide to prevent mycobacterial infection after face lifting thread implant in futurehttps://www.allbiosolution.com/2023/10/a-rare-atypical-mycobacterial-infection.htmlAllbiosolution
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16Comparative Assessment of Filgrastim Bio-similars via vertical gel electrophoresis (SDS-PAGE) and HPLC Priyanka Chaudhary, Muthusamy Kalaivani, Kashish Chaudhary, Anubhuti Goyal, Meenakshi Dahiya, Rajeev Singh Raghuvanshi2024.07Filgrastim, Bio-similar, Physicochemical, SDS-PAGE, HPLCJournal of ALLBIOSOLUTION2605-35352605-353561Background: Filgrastim bio-similar have emerged as cost-effective alternatives to the reference filgrastim, providing comparable efficacy and safety profiles. Objective: In this study, we aim to show physico-chemical similarity between filgrastim biosimilars using vertical gel electrophoresis & high-performance liquid chromatography. Materials & Methods: In the present study, we evaluate filgrastim biosimilars (grafeel, religrast, neukine, colstim, emigrast) via SDS-PAGE and HPLC thereby checking their molecular weights for similarity and their qualitative analysis. The same was compared with reference standard of filgrastim (Filgrastim, certified Reference Material). Results: In the scope of the data obtained, we found that the main band of filgrastim in filgrastim biosimilars has the same electrophoretic mobility as the reference standard under non-reduced circumstances in case of SDS-PAGE, the outcomes demonstrated that the position of the principal band in the electropherogram produced by the test solution and the principal band produced by the reference solution are similar. The retention time of the main peak obtained with the test solution and the peak obtained with the reference solution are similar. For HPLC, all the filgrastim biosimilars showed monomer peaks on the RP-HPLC chromatograms, which eluted at 12.4 minutes, matching the retention duration of the filgrastim reference standard. Conclusion: Filgrastim has transformed the management of neutropenia and has become an indispensable therapy in various clinical settings. The development and approval of filgrastim biosimilars have expanded treatment options and improved accessibility, offered cost-effective alternatives while maintained comparable safety and efficacy. . https://www.allbiosolution.com/2024/06/comparative-assessment-of-filgrastim.htmlAllbiosolution
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