2019-08-18 CRC Screening Modeling

	A	B	C	D	E	F	G	H	I	J
1	Test	Overall sensitivity	Specificity	TPR	FPR	TNR	FNR	PPV	NPV
2	Grail 2019	0.677671875	0.99	0.00441	0.00993	0.98356	0.00210	30.74%	99.79%
3	Guardant 2019 (spec90)	0.886875	0.9	0.00577	0.09935	0.89414	0.00074	5.49%	99.92%
4	Guardant 2019 (spec95)	0.84078125	0.95	0.00547	0.04967	0.94382	0.00104	9.92%	99.89%
5	Guardant 2019 (spec98)	0.7528125	0.98	0.00490	0.01987	0.97362	0.00161	19.78%	99.84%
6	Cologuard	0.917734375	0.866	0.00597	0.13313	0.86036	0.00054	4.29%	99.94%
7	FIT	0.73365625	0.949	0.00477	0.05067	0.94282	0.00173	8.61%	99.82%
8	No screening	0	1	0.00000	0.00000	0.99349	0.00651	#DIV/0!	99.35%
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12	Test	Price	Adherence	Positive rate	False negative rate	Screen cost/person	Followup cost/person	False negative cost/person	years between tests	Cost per person/year
13	Grail 2019	$482.00	0.86	0.01233639582	0.002714800499	$414.52	$14.80	$69.62	3	$166.31
14	Guardant 2019 (spec90)	$482.00	0.86	0.09040347507	0.001544067224	$414.52	$108.48	$39.60	3	$187.53
15	Guardant 2019 (spec95)	$482.00	0.86	0.04742533506	0.001802015029	$414.52	$56.91	$46.21	3	$172.55
16	Guardant 2019 (spec98)	$482.00	0.86	0.0213009329	0.002294301857	$414.52	$25.56	$58.84	3	$166.31
17	Cologuard	$482.00	0.655	0.09111042357	0.00259560106	$315.71	$109.33	$66.56	3	$163.87
18	FIT	$50.00	0.655	0.03631460955	0.00338017671	$32.75	$43.58	$86.68	1	$163.01
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