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While searching the wordsearch one should notice that each guest if from a group of four. In the wordsearch 3 of the 4 items in the group can be found. Once all the missing words are gathered one can take the "heart" or center letter of the word to extract the final solution.
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EOE
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TopicGiven GuestOther GuestOther GuestMissing GuestMiddle LetterRNDNENIS
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UK countriesEnglandScotlandNorthern IrelandWalesLOIRSIADENINE
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HumoursBlack bilePhlegmYellow bileBloodONMACRSNNJAGNAD
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School ClassesFreshmanSeniorJuniorSophomoreOAANOODOOHNARLAHA
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Japan's main islandsHonshuKyushuHokkaidoShikokuKEFOTNINTZCHSMTAUAP
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Fantastic Four(Mr.) Fantastic
(The) Human Torch
(The) Invisible Woman
(The) ThingILEDLANOIYROHHNGTS
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VoicesSopranoBassAltoTenorNELAREMRECONJSD
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Gospels in the BibleMarkJohnLukeMatthewTNRPSFALTEKULEM
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Ninja TurtlesLeonardoMichelangeloDonatelloRaphaelHDNORTHERNIRELANDRYNRB
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Four Corners StatesColoradoArizonaUtahNew MexicoESLDROAAUIFMFL
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Horsemen of the ApocalypseFamineDeathPestilenceWarAEOINVISIBLEWOMANSOAIA
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Classical elementsEarthFireAirWaterTCSEBUTAHRNCC
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Cardinal directionsWestSouthEastNorthRNDEATHSDIHUTHHK
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Good Place humansTahaniEleanorJasonChidiIESBTOLTHAEOB
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Playing Card SuitsSpadesHeartsDiamondsClubsULTUMNESSLKI
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DNA BasesAdenineGuanineCytosineThymineMIROGANTAKL
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TASETOINAE
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SELEHCGI
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EHLAED
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PLLO
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OT
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O
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