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1 | # | Title | Reference | Date published | Link to article | Meta-analysis, Review or Primary? | Approach | Location | |||||||||||||||||||
2 | 1 | Laboratory abnormalities in children with novel coronavirus disease 2019 | Henry, B., Lippi, G. & Plebani, M. (2020). Laboratory abnormalities in children with novel coronavirus disease 2019. Clinical Chemistry and Laboratory Medicine (CCLM), 0(0), pp. doi:10.1515/cclm-2020-0272 | Received March 7, 2020; accepted March 8, 2020 | https://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-2020-0272/cclm-2020-0272.xml | Meta-analysis | Meta-analysis through 3/5/2020 for COVID-19 in patients 19 and under. 12 Articles include with total n=66 pediatric patients. | Most China, 1 Singapore | |||||||||||||||||||
3 | 2 | Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis | G. Lippi, M. Plebani, B. Michael Henry, Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis, Clinica Chimica Acta (2020), doi: https:// doi.org/10.1016/j.cca.2020.03.022 | 3/8/2020 | https://www.sciencedirect.com/science/article/pii/S0009898120301248?via%3Dihub | Meta-analysis | Meta-analysis of reports on COVID19 that also reported on platelet numbers. 9 studies, 1779 COVID19 patients. 8 China, 1 Singapore study. | 8 studies from China, 1 Singapore | |||||||||||||||||||
4 | 3 | Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19):Evidence from a meta-analysis, | G. Lippi, C.J. Lavie and F. Sanchis-Gomar, Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19):Evidence from a meta-analysis, Progress in Cardiovascular Diseases,https://doi.org/10.1016/j.pcad.2020.03.001 | 3/10/2020 | https://www.sciencedirect.com/science/article/pii/S0033062020300554?via%3Dihub | Meta-analysis | Meta-analysis of 4 studies that reported cTnI for COVID19 Patients | Studies from China. | |||||||||||||||||||
5 | 4 | Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis | Giuseppe Lippi, Mario Plebani, Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis, Clinica Chimica Acta, Volume 505, 2020, Pages 190-191, ISSN 0009-8981, https://doi.org/10.1016/j.cca.2020.03.004. | 3/3/2020 | https://www.sciencedirect.com/science/article/pii/S0009898120301066?via%3Dihub | Meta-analysis | Meta-analysis of 4 studies that reported procalcitonin | Studies from China. | |||||||||||||||||||
6 | 5 | Hematologic parameters in patients with COVID‐19 infection | Fan, B.E., Chong, V.C.L., Chan, S.S.W., Lim, G.H., Lim, K.G.E., Tan, G.B., Mucheli, S.S., Kuperan, P. and Ong, K.H. (2020), Hematologic parameters in patients with COVID‐19 infection. Am J Hematol. doi:10.1002/ajh.25774 | 3/2/2020 | https://onlinelibrary.wiley.com/doi/10.1002/ajh.25774 | Primary | Report of 96 patients treated at the National Centre for Infectious Diseases (NCID). | Singapore | |||||||||||||||||||
7 | 6 | Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia | Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;00:1–4 | 2/13/2020 | https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14768 | Primary | 183 patients with COVID19 | Wuhan, China | |||||||||||||||||||
8 | 7 | COVID-19: consider cytokine storm syndromes and immunosuppression. | Mehta P, McAuley D, Brown M, Sanchez E, Tattersall R, Manson J, et al. COVID-19: consider cytokine store syndromes and immunosuppression. Lancet. March 16, 2020. DOI:https://doi.org/10.1016/S0140-6736(20)30628-0 | Published online 3/13/2020 | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext | Meta-analysis | Hscore. No methods given for data included | Unknown. | |||||||||||||||||||
9 | 8 | Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China | Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069. doi:10.1001/jama.2020.1585 | Published 2/7/2020 | https://jamanetwork.com/journals/jama/fullarticle/2761044 | Primary | Retrospective analysis of 138 Wuhan patients from 1/1/2020-1/28/2020 | Wuhan, Chaina | |||||||||||||||||||
10 | 9 | Liver injury in COVID-19: management and challenges | Chao Zhang, Lei Shi, Fu-Sheng Wang, Liver injury in COVID-19: management and challenges, The Lancet Gastroenterology & Hepatology, 2020, ISSN 2468-1253, https://doi.org/10.1016/S2468-1253(20)30057-1. | Published 3/4/2020 | https://www.sciencedirect.com/science/article/pii/S2468125320300571?via%3Dihub | Review | Cited 7 studies and the author's own unpublished data. | China | |||||||||||||||||||
11 | 10 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury | Liu, Y., Yang, Y., Zhang, C. et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci. China Life Sci. 63, 364–374 (2020). https://doi.org/10.1007/s11427-020-1643-8 | 2/5/2020 | https://link.springer.com/article/10.1007%2Fs11427-020-1643-8 | Primary | Report of N=12 cases in Shenzhen, China. All developed pneumonia and half developed ARDS. | Shenzhen, China | |||||||||||||||||||
12 | 11 | Prominent changes in blood coagulation of patients with SARS-CoV-2 infection | Han Huan, Yang Lan, Lie Rui et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical Chemistry and Laboratory Medicine (CCLM), 20200188, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2020-0188. | 2/22/2020 | https://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-2020-0188/cclm-2020-0188.xml | Primary | 94 patients with confirmed SARSCoV- 2 admitted in Renmin Hospital . Prospectively collected coagulation data in these patients and in 40 healthy controls during the same period | Wuhan, China | |||||||||||||||||||
13 | 12 | Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China | Chaolin Huang, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying Gu, Zhenshun Cheng, Ting Yu, Jiaan Xia, Yuan Wei, Wenjuan Wu, Xuelei Xie, Wen Yin, Hui Li, Min Liu, Yan Xiao, Hong Gao, Li Guo, Jungang Xie, Guangfa Wang, Rongmeng Jiang, Zhancheng Gao, Qi Jin, Jianwei Wang, Bin Cao, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet, Volume 395, Issue 10223, 2020, Pages 497-506, ISSN 0140-6736, https://doi.org/10.1016/S0140-6736(20)30183-5. | Published Online January 24, 2020 | https://www.sciencedirect.com/science/article/pii/S0140673620301835?via%3Dihub | Primary | All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. | Jin Yin-tan Hospital (Wuhan, China) | |||||||||||||||||||
14 | 13 | The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks | Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med. 2020 Mar 19. pii: /j/cclm.ahead-of-print/cclm-2020-0240/cclm-2020-0240.xml. doi10.1515/cclm-2020-0240. [Epub ahead of print] PubMed PMID: 32191623 | Received: 3/3/2020 Accepted: 3/4/2020 | https://www.degruyter.com/view/journals/cclm/ahead-of-print/article-10.1515-cclm-2020-0240/article-10.1515-cclm-2020-0240.xml | Review | |||||||||||||||||||||
15 | 14 | Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study | X. Yang, Y. Yu, J. Xu, H. Shu, J. Xia, H. Liu, Y. Wu, L. Zhang, Z. Yu, M. Fang, T. Yu, Y. Wang, S. Pan, X. Zou, S. Yuan, Y. Shang, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, The Lancet Respiratory Medicine. 0 (2020). https://doi.org/10.1016/S2213-2600(20)30079-5. | Published online: 2/21/2020 | https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext | Primary | Single-centered, retrospective, observational study of 52 critically ill adult patients with SARS-CoV-2 pneumonia who were admitted to the (ICU) between late December, 2019, and Jan 26, 2020 | Wuhan Jin Yin-tan hospital (Wuhan, China) | |||||||||||||||||||
16 | 15 | Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China | Q. Ruan, K. Yang, W. Wang, L. Jiang, J. Song, Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, Intensive Care Med. (2020). https://doi.org/10.1007/s00134-020-05991-x. | 3/3/2020 | https://link.springer.com/article/10.1007/s00134-020-05991-x | Primary | Retrospective multicenter study of 68 death cases (68/150, 45%) and 82 discharged cases (82/150, 55%) with laboratory-confirmed infection of SARS-CoV-2 | Jin Yin-tan Hospital and Tongji Hospital (Wuhan, China) | |||||||||||||||||||
17 | 16 | Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. | Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, etal Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). www.lancovid.org. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020 Mar 13:101623. doi: 10.1016/... [Epub ahead of print] Review. PubMed PMID: 32179124 | Available online 13 March 2020 | https://www.sciencedirect.com/science/article/pii/S1477893920300910 | Meta-analysis | 19 studies on COVID19 patients included in analysis | 18 studies from China, 1 from Australia | |||||||||||||||||||
18 | 17 | Clinical Characteristics of Coronavirus Disease 2019 in China | Guan, Wei-Jie, et al. “Clinical Characteristics of Coronavirus Disease 2019 in China.” New England Journal of Medicine, 2020, doi:10.1056/nejmoa2002032. | 2/28/2020 | https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 | Primary | Extracted data for 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces through January 29, 2020. | China | |||||||||||||||||||
19 | 18 | Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study | F. Zhou, T. Yu, R. Du, G. Fan, Y. Liu, Z. Liu, J. Xiang, B. Wang, B. Song, X. Gu, L. Guan, T. Wei, H. Li, X. Wu, J. Xu, S. Tu, Y. Zhang, H. Chen, B. Cao, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet. (2020). | Published online 3/9/2020 | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30566-3/fulltext | Primary | All adult inpatients (N=197) with lab-confirmed COVID-19 who had been discharged or had died by Jan 31, 2020. | Jinyintan Hospital and Wuhan Pulmonary Hospital, Wuhan, China | |||||||||||||||||||
20 | 19 | Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore | B.E. Young, S.W.X. Ong, S. Kalimuddin, J.G. Low, S.Y. Tan, J. Loh, O.-T. Ng, K. Marimuthu, L.W. Ang, T.M. Mak, S.K. Lau, D.E. Anderson, K.S. Chan, T.Y. Tan, T.Y. Ng, L. Cui, Z. Said, L. Kurupatham, M.I.-C. Chen, M. Chan, S. Vasoo, L.-F. Wang, B.H. Tan, R.T.P. Lin, V.J.M. Lee, Y.-S. Leo, D.C. Lye, Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore, JAMA. (2020). https://doi.org/10.1001/jama.2020.3204. | Accepted 2/27/2020 | https://jamanetwork.com/journals/jama/fullarticle/2762688 | Primary | Descriptive case series of the first 18 patients with SARS-CoV-2 infection in Singapore between January 23 and February 3, 2020 | Singapore | |||||||||||||||||||
21 | 20 | Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease | W. Liu, Z.-W. Tao, W. Lei, Y. Ming-Li, L. Kui, Z. Ling, W. Shuang, D. Yan, L. Jing, H.-G. Liu, Y. Ming, H. Yi, Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease, Chin. Med. J. (2020). https://doi.org/10.1097/CM9.0000000000000775. | Published 2/28/2020 | https://journals.lww.com/cmj/Abstract/publishahead/Analysis_of_factors_associated_with_disease.99363.aspx | Primary | 78 patients with PCR confirmed COVID19 induced-pneumonia admitted to three tertiary hospitals in Wuhan between December 30, 2019, and January 15, 2020. | Wuhan, China | |||||||||||||||||||
22 | 21 | Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State | Arentz M, Yim E, Klaff L, et al. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA. March 19, 2020. doi:10.1001/jama.2020.4326 | Published online 3/19/2020 | https://jamanetwork.com/journals/jama/fullarticle/2763485 | Primary | Report of 21 incident cases of COVID-19 admitted to the intensive care unit (ICU) at Evergreen Hospital | Seattle, WA | |||||||||||||||||||
23 | 22 | Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study | Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020 Mar 25. pii: S1473-3099(20)30198-5. doi: 10.1016/S1473-3099(20)30198-5. [Epub ahead of print] | Published online 3/25/2020 | https://www.sciencedirect.com/science/article/pii/S1473309920301985?via%3Dihub | Primary | 36 children in an observational cohort study at 3 hospitals in Zhejiang province, China. Included all paediatric patients (aged 0–16 years) with laboratory confirmed COVID-19. | Zhejiang province, China | |||||||||||||||||||
24 | 23 | Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China | Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H, Yang B, Huang. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. CJAMA Cardiol. 2020 Mar 25. doi: 10.1001/jamacardio.2020.0950. [Epub ahead of print] | Published online March 25, 2020 | https://jamanetwork.com/journals/jamacardiology/fullarticle/2763524 | Primary | 416 lab-confirmed COVID19 consecutive inpatients cohort study from January 20, 2020, to February 10, 2020, in a single center at Renmin Hospital of Wuhan University, Wuhan, China; the final date of follow-up was February 15, 2020. | Wuhan, China | |||||||||||||||||||
25 | 24 | Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study | Sun, D., Li, H., Lu, X. et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr (2020). https://doi.org/10.1007/s12519-020-00354-4 | Published March 19, 2020 | https://link.springer.com/article/10.1007%2Fs12519-020-00354-4 | Primary | 8 severe or critically ill patients with COVID-19 who were treated at the Intensive Care Unit (ICU), Wuhan Children’s Hospital from January 24 to February 24. | Wuhan, China | |||||||||||||||||||
26 | 25 | Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing [Articel in Chinese] | Zhang MQ, Wang XH, Chen YL, Zhao KL, Cai YQ, An CL, Lin MG, Mu XD. Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):215-218. doi: 10.3760/cma.j.issn.1001-0939.2020.03.015. | 3/12/2020 | https://www.ncbi.nlm.nih.gov/pubmed/32164091 | Primary | Retrospective analysis of clinical and imaging data of 9 patients with 2019 novel coronavirus infection diagnosed in one fever clinic in Beijing from January 18, 2020 to February 3, 2020. | Beijing, China | |||||||||||||||||||
27 | 26 | Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia [article in Chinese] | Chen L, Liu HG, Liu W, Liu J, Liu K, Shang J, Deng Y, Wei S. Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):203-208. doi: 10.3760/cma.j.issn.1001-0939.2020.03.013. | 3/12/2020 | https://www.ncbi.nlm.nih.gov/pubmed/32164089 | Primary | 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects | Wuhan, China | |||||||||||||||||||
28 | 27 | Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID‐19 | Gao, Y., Li, T., Han, M., Li, X., Wu, D., Xu, Y., Zhu, Y., Liu, Y., Wang, X. and Wang, L. (2020), Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID‐19. J Med Virol. Accepted Author Manuscript. doi:10.1002/jmv.25770 | 3/17/2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25770 | Primary | Retrospective study on COVID-9 patients (severe= 15, mild=28 patients) from January 23, 2020 to February 2, 2020 in the Fuyang Second people's hospital. | Fuyang, Anhui, China | |||||||||||||||||||
29 | 28 | Clinical Predictors of Severity Based on an Analysis of Data of COVID-19 Pneumonia | Ran, Jun and Dai, Bin and Wang, Desheng and Li, Xiao Ming, Clinical Predictors of Severity Based on an Analysis of Data of COVID-19 Pneumonia (3/20/2020).http://dx.doi.org/10.2139/ssrn.3559525 | Posted as pre-print 4/1/2020 | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3559525 | Primary Pre-Print | All the confirmed COVID-19 patients (N=144) hospitalized in Tongji hospital from January 17 to March 3, 2020 | Hubei, China | |||||||||||||||||||
30 | 29 | Clinical Features and Risk Factors for the Severity of Inpatients with COVID-19: A Retrospective Cohort Study | Zheng, Xinchun and Chen, Jiehua and Deng, Lisi and Fang, Zuxiong and Chen, Gongqi and Ye, Di and Hong, Zhongsi and Xia, Jinyu, Clinical Features and Risk Factors for the Severity of Inpatients with COVID-19: A Retrospective Cohort Study (3/24/2020). http://dx.doi.org/10.2139/ssrn.3562460 | Posted as pre-print 4/6/2020 | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3562460 | Primary Pre-Print | Retrospective cohort study included in-hospital patients (N=52) with laboratory confirmed COVID-19 from the Fifth Affiliated Hospital of Sun Yat-Sen University (Zhuhai, China) who had been discharged by Mar 9, 2020. | Zhuhai, China | |||||||||||||||||||
31 | 30 | Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study | Mardani R, Ahmadi Vasmehjani A, Zali F, et al. Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. Arch Acad Emerg Med. 2020;8(1):e43. Published 2020 Apr 4. | Received: February 2020; Accepted: March 2020; Published online: 4 April 2020 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130449/ | Primary | Study was conducted on suspected COVID-19 patients (N=200), who presented to Behpooyan Clinic Medical center in Tehran (Iran) from 22 February to 14 March, 2020. Patients were divided into two groups based on the results of real time reverse transcriptase-polymerase chain reaction (RT-PCR) for COVID-19, and the accuracy of different laboratory parameters in predicting cases with positive RT-PCR was evaluated using area under the ROC curve (AUC). | Tehran, Iran | |||||||||||||||||||
32 | 31 | Neutrophil‐to‐lymphocyte ratio and lymphocyte‐to‐C‐reactive protein ratio in patients with severe coronavirus disease 2019 (COVID‐19): A meta‐analysis | Lagunas‐Rangel, F.A. (2020), Neutrophil‐to‐lymphocyte ratio and lymphocyte‐to‐C‐reactive protein ratio in patients with severe coronavirus disease 2019 (COVID‐19): A meta‐analysis. J Med Virol. doi:10.1002/jmv.25819 | First published:03 April 2020 | https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25819 | Meta-analysis | Meta‐analysis investigating whether NLR and LCR values can help predict clinical severity in patients with COVID‐19. 6 studies included (all from China, with a total N=828 patients) | China | |||||||||||||||||||
33 | 32 | Elevations of serum cancer biomarkers correlate with severity of COVID‐19 | Wei, X., Su, J., Yang, K., Wei, J., Wan, H., Cao, X., Tan, W. and Wang, H. (2020), Elevations of serum cancer biomarkers correlate with severity of COVID‐19. J Med Virol. Accepted Author Manuscript. doi:10.1002/jmv.25957 | First published:29 April 2020 | https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25957 | Retrospective | Retrospective study, evaluated the levels of serum cancer biomarkers (HE4, CYFRA21-1, CA125, CEA, and CA153) in COVID-19 patients (mild: 131; severe: 98; critical: 23). | Union Hospital of Tongji Medical College, Wuhan, Hubei, China | |||||||||||||||||||
34 | 33 | Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020 | Colaneri Marta, Sacchi Paolo, Zuccaro Valentina, Biscarini Simona, Sachs Michele, Roda Silvia, Pieri Teresa Chiara, Valsecchi Pietro, Piralla Antonio, Seminari Elena, Di Matteo Angela, Novati Stefano, Maiocchi Laura, Pagnucco Layla, Tirani Marcello, Baldanti Fausto, Mojoli Francesco, Perlini Stefano, Bruno Raffaele, the COVID19 IRCCS San Matteo Pavia Task Force. Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020. Euro Surveill. 2020;25(16):pii=2000460. https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000460 | Received: 29 Mar 2020; Accepted: 23 Apr 2020 | https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.16.2000460 | Retrospective | Extracted data from medical records of all consecutive patients admitted with a diagnosis of COVID-19, between 21 and 28 February 2020 and followed-up until 4 March 2020 (N=44) | Pavia, North Italy | |||||||||||||||||||
35 | 34 | Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States | Kujawski, S.A., Wong, K.K., Collins, J.P. et al. Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States. Nat Med (2020). https://doi.org/10.1038/s41591-020-0877-5 | Received14 March 2020 Accepted06 April 2020 Published23 April 2020 | https://www.nature.com/articles/s41591-020-0877-5 | Retrospective Case Series | Case series describes the first 12 US patients confirmed to have COVID-19 from 20 January to 5 February 2020, including 4 patients described previously | United States | |||||||||||||||||||
36 | 35 | Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. | Pavan K. Bhatraju, M.D., Bijan J. Ghassemieh, M.D., Michelle Nichols, M.D., Richard Kim, M.D., Keith R. Jerome, M.D., Arun K. Nalla, Ph.D., Alexander L. Greninger, M.D., Sudhakar Pipavath, M.D., Mark M. Wurfel, M.D., Ph.D., Laura Evans, M.D., Patricia A. Kritek, M.D., T. Eoin West, M.D., M.P.H., Andrew Luks, M.D., Anthony Gerbino, M.D., Chris R. Dale, M.D., Jason D. Goldman, M.D., Shane O’Mahony, M.D., and Carmen Mikacenic, M.D. Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. N Engl J Med. 2020 Mar 30. doi: 10.1056/NEJMoa2004500. [Epub ahead of print] | March 30, 2020 | https://www.nejm.org/doi/full/10.1056/NEJMoa2004500 | Retrospective chart review | Identified 24 patients from 9 Seattle-area hospitals who were admitted to the ICU with confirmed infection with SARS-CoV-2. Review of medical records through March 23, 2020. Each patient had at least 14 days of follow-up. | Seattle, WA, United States | |||||||||||||||||||
37 | 36 | Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study | Yingzhen Du , Lei Tu , Pingjun Zhu , Mi Mu , Runsheng Wang , Pengcheng Yang , Xi Wang , Chao Hu , Rongyu Ping , Peng Hu , Tianzhi Li , Feng Cao , Christopher Chang ; Qinyong Hu ; Yang Jin , and Guogang Xu. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study. Am J Respir Crit Care Med. 2020 Apr 3. doi: 10.1164/rccm.202003-0543OC. [Epub ahead of print] | Received: March 06, 2020 Accepted: April 02, 2020 Published Online: April 03, 2020 | https://www.atsjournals.org/doi/abs/10.1164/rccm.202003-0543OC | Retrospective chart review | Medical records of 85 fatal cases of COVID-19 between January 9 and February 15, 2020 were collected. Information recorded included medical history, exposure history, comorbidities, symptoms, signs, laboratory findings, CT scans and clinical management. | Wuhan, China | |||||||||||||||||||
38 | 37 | First case of placental infection with SARS-CoV-2 | Hillary Hosier, Shelli Farhadian, Raffaella Morotti, Uma Deshmukh, Alice Lu-Culligans, Katherine Campbell, Yuki Yasumoto, Chantal Vogels, Arnau Casanovas-Massana, Pavithra Vijayakumar, Bertie Geng, Camila Odio, John Fournier, Anderson Brito, Joseph Fauver, Feimei Liu, Tara Alpert, Reshef Tal, Klara Szigeti-Buck, Sudhir Perincheri, Christopher Larsen, Aileen Gariepy, Gabriela Aguilar, Kristen Fardelmann, Malini Harigopal, Hugh Taylor, Christian Pettker, Anne Wyllie, Charles Dela Cruz, Aaron Ring, Nathan Grubaugh, Albert Ko, Tamas Horvath, Akiko Iwasaki, Uma Reddy, Heather Lipkind. First case of placental infection with SARS-CoV-2. Medrxiv. doi: https://doi.org/10.1101/2020.04.30.20083907 [PREPRINT] | PREPRINT; Posted May 05, 2020. | https://www.medrxiv.org/content/10.1101/2020.04.30.20083907v1 | Case Report | Report on a patient with preeclampsia and Covid19 positive. Analyzed placenta for the presence of SARS-CoV-2 through molecular and immunohistochemical assays and by and electron microscopy, and measured the maternal antibody response in blood to this infection. Reported lab results from her presentation to postop day 3. | Yale New Haven Hospital, New Haven, CT, USA | |||||||||||||||||||
39 | 38 | Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 | Geleris, J., Sun, Y., Platt, J., Zucker, J., Baldwin, M., Hripcsak, G., . . . Schluger, N. W. (2020). Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. New England Journal of Medicine. doi:10.1056/nejmoa2012410 | May 7, 2020 | https://www.nejm.org/doi/full/10.1056/NEJMoa2012410?query=featured_coronavirus | Retrospective | Examined the association between hydroxychloroquine use and intubation or death at a large medical center in New York City. Reported on few COVID19-associated laboratory parameters of patients in the study. N=1376 | New York–Presbyterian Hospital (NYP)–Columbia University Irving Medical Center (CUIMC) in New York City, NY, USA | |||||||||||||||||||
40 | 39 | Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing | Kurstjens, S., van der Horst, A., Herpers, R., Geerits, M. L., Kluiters-de Hingh, Y. M., Göttgens, E., Blaauw, M. T., Thelen, M. M., Elisen, M. M., & Kusters, R. (2020). Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing, Clinical Chemistry and Laboratory Medicine (CCLM), 58(9), 1587-1593. doi: https://doi.org/10.1515/cclm-2020-0593 | 29 Jun 2020 | https://www.degruyter.com/view/journals/cclm/58/9/article-p1587.xml | Retrospective | 375 patients from three different hospitals presenting at the ED with respiratory symptoms, or suspected COVID-19 infection because of e.g. gastro-intestinal complaints (1–2% of this cohort), and subsequent SARS-CoV-2 RT-PCR testing were included. Use results from routine labs (CRP, LDH, ferritin, ANC and ALC) in addition to demographics and x-ray/ct results to build a point-based algorithm to discriminate between patients positive for SARS-CoV-2 or negative (by RT-PCR). | the Netherlands | |||||||||||||||||||
41 | 40 | Covid-19 in Critically Ill Patients in the Seattle Region — Case Series | PK Bhatraju, BJ Ghassemieh, M Nichols, et al. Covid-19 in critically ill patients in the Seattle region—case series N Engl J Med (2020) | May 21, 2020 | https://www.nejm.org/doi/10.1056/NEJMoa2004500 | 24 adult patient with lab-confirmed Covid-19 infection who were admitted to nine hospital ICUs in the Seattle region between February 24 and March 9, 2020. | Seattle, WA. USA | ||||||||||||||||||||
42 | 41 | Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line | Ciccullo A, Borghetti A, Zileri Dal Verme L, et al. Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. Int J Antimicrob Agents. 2020;56(2):106017. doi:10.1016/j.ijantimicag.2020.106017 | Published online 2020 May 11 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211594/ | Retrospective | |||||||||||||||||||||
43 | 42 | Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19 | Kong M, Zhang H, Cao X, Mao X, Lu Z. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol Infect. 2020;148:e139. Published 2020 Jul 9. doi:10.1017/S0950268820001557 | Published online 2020 Jul 9. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360950/ | Retrospective | |||||||||||||||||||||
44 | 43 | Usefulness of biological markers in the early prediction of corona virus disease-2019 severity. | Bennouar S, Bachir Cherif A, Kessira A, Hamel H, Boudahdir A, Bouamra A, Bennouar D, Abdi S. Usefulness of biological markers in the early prediction of corona virus disease-2019 severity. Scand J Clin Lab Invest. 2020 Sep 18:1-8. doi: 10.1080/00365513.2020.1821396. Epub ahead of print. PMID: 32945705. | https://pubmed.ncbi.nlm.nih.gov/32945705/ | Retrospective | This is a prospective, single-center, cohort study involving 330 SARS-CoV-2 infected patients who were admitted at the University Hospital of Blida, Algeria in the period between the 27th of March and 22nd of April 2020. | Algeria | ||||||||||||||||||||
45 | 44 | Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution | Sepulchre E, Pittie G, Stojkovic V, Haesbroek G, Crama Y, Schyns M, Paridaens H, de Marchin J, Degesves S, Biemar C, Boccar S, Senterre JM, Minon JM. Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution. Acta Clin Belg. 2020 Sep 16:1-7. doi: 10.1080/17843286.2020.1822078. Epub ahead of print. PMID: 32935644. | https://pubmed.ncbi.nlm.nih.gov/32935644/ | |||||||||||||||||||||||
46 | 44 | C-reactive protein and albumin association with mortality of hospitalised SARS-CoV-2 patients: A tertiary hospital experience | Bannaga AS, Tabuso M, Farrugia A, Chandrapalan S, Somal K, Lim VK, Mohamed S, Nia GJ, Mannath J, Wong JL, Noufaily A, Disney BR, Arasaradnam RP. C-reactive protein and albumin association with mortality of hospitalised SARS-CoV-2 patients: A tertiary hospital experience. Clin Med (Lond). 2020 Sep;20(5):463-467. doi: 10.7861/clinmed.2020-0424. PMID: 32934038. | https://pubmed.ncbi.nlm.nih.gov/32934038/ | Logistic regression analyses were performed for 321 patients admitted to University Hospital, University Hospitals Coventry and Warwickshire NHS Trust, between 24 January 2020 - 13 April 2020. | Coventry, UK | |||||||||||||||||||||
47 | 44 | Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection | Maguire D, Woods M, Richards C, Dolan R, Veitch JW, Sim WMJ, Kemmett OEH, Milton DC, Randall SLW, Bui LD, Goldmann N, Cameron A, Laird B, Talwar D, Godber I, Davidson A, McMillan DC. Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection. J Transl Med. 2020 Sep 15;18(1):354. doi: 10.1186/s12967-020-02524-4. PMID: 32933530. | 2020 Sep 15 | https://pubmed.ncbi.nlm.nih.gov/32933530/ | Electronic patient records for patients who were admitted to an urban teaching hospital during the initial 7-week period of the COVID-19 pandemic in Glasgow, U.K. (17th March 2020-1st May 2020) were examined for routine clinical, laboratory and clinical outcome data. Age, sex, BMI and documented evidence of COVID-19 infection at time of discharge or death certification were considered minimal criteria for inclusion. | Glaskgow, UK | ||||||||||||||||||||
48 | 44 | Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China | Xu JB, Xu C, Zhang RB, Wu M, Pan CK, Li XJ, Wang Q, Zeng FF, Zhu S. Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China. Sci Rep. 2020 Sep 14;10(1):15058. doi: 10.1038/s41598-020-72164-7. PMID: 32929124. | 2020 Sep 14 | https://pubmed.ncbi.nlm.nih.gov/32929124/ | ||||||||||||||||||||||
49 | 44 | Lymphopenia and neutrophilia at admission predicts severity and mortality in patients with COVID-19: a meta-analysis | Henry B, Cheruiyot I, Vikse J, Mutua V, Kipkorir V, Benoit J, Plebani M, Bragazzi N, Lippi G. Lymphopenia and neutrophilia at admission predicts severity and mortality in patients with COVID-19: a meta-analysis. Acta Biomed. 2020 Sep 7;91(3):e2020008. doi: 10.23750/abm.v91i3.10217. PMID: 32921706. | 2020 Sep 7 | https://pubmed.ncbi.nlm.nih.gov/32921706/ | An electronic search was carried out in PubMed, China National Knowledge Infrastructure (CNKI) and Cochrane Central Register of Controlled Trials (CENTRAL) to identify eligible studies reporting frequency data on neutrophilia and lymphopenia at admission in hospitalization in COVID-19 patients. Pooled odds ratios of clinical outcomes for each parameter were calculated using Comprehensive Meta-Analysis. Results: A total of 22 studies (4,969 patients) were included in this meta-analysis. | |||||||||||||||||||||
50 | 44 | Coagulation abnormalities and thrombosis in patients with COVID-19 | Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020 Jun;7(6):e438-e440. doi: 10.1016/S2352-3026(20)30145-9. Epub 2020 May 11. PMID: 32407672; PMCID: PMC7213964. | 2020 May 11 | https://pubmed.ncbi.nlm.nih.gov/32407672/ | ||||||||||||||||||||||
51 | Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak | 3/2021 | https://www.sciencedirect.com/science/article/pii/S2213716520302915?via%3Dihub | Case series of 3 patients: "Three COVID-19 patients with cytokine panel revealing elevation of IL-6 but normal levels of IL-10, INF-γ and IL-8. This contrasts with the cytokine signature described in SARS and MERS. Evidence of compromised T-cell IFN-γ response in two of these patients. Unlike other inflammatory conditions, e.g. ARDS, MERS and SARS, no elevation of IL-1β was observed." | |||||||||||||||||||||||
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