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1 | Function | 功能 | Article Title | Journal | Link | |||||||||||||||||||||||
2 | General | 一般資訊 | Sea Cucumber | https://en.wikipedia.org/wiki/Sea_cucumber | ||||||||||||||||||||||||
3 | Saponins ( Triterpene Glycosides) | https://en.wikipedia.org/wiki/Saponin | ||||||||||||||||||||||||||
4 | Active Ingredients of Sea Cucumber | 海參活性成分 | Medicinal and health benefit effects of functional sea cucumbers | 功能性海參的藥用和保健功用 | Journal of Traditional and Complementary Medicine. Volume 8, Issue 3, July 2018, Pages 341-351 | https://www.sciencedirect.com/science/article/pii/S222541101730069X | ||||||||||||||||||||||
5 | Pharmacological Potential of Sea Cucumbers | 海參的藥用潛力 | International Journal of Molecular Science. 2018 May; 19(5): 1342. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983632/ | ||||||||||||||||||||||||
6 | High-Value Components and Bioactives from Sea Cucumbers for Functional Foods - A Review | 海參中用於保健食品的高價值成分和生物活性成分- 回顧 | Marine Drugs, 2011 9:1761-1805 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210605/ | ||||||||||||||||||||||||
7 | Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades | 過去六十年記錄的海參乙酰化三萜糖苷 (Acetylated Triterpene Glycosides) 及其生物活性 | Marine Drugs, 2016 Aug; 14(8): 147. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999908/ | ||||||||||||||||||||||||
8 | Immune Enhancer | 海參對免疫系統的保健 | Effects of sulfated fucan from the sea cucumber Stichopus japonicus on natural killer cell activation and cytotoxicity | 刺參 (Stichopus japonicus) 中的硫化聚海藻糖 (Sulfated Fucan)對激活自然殺手細胞和其細胞毒性的影響 | International Journal of Biological Macromolecules. Volume 108, March 2018, Pages 177-184 | https://www.sciencedirect.com/science/article/pii/S0141813017326843 | ||||||||||||||||||||||
9 | Dietary Apostichopus japonicus enhances the respiratory and intestinal mucosal immunity in immunosuppressive mice. | 日本刺參（Apostichopus japonicus）增強在免疫抑制老鼠中的呼吸道和腸道粘膜免疫力 | Bioscience, Biotechnology, and Biochemistry. Volume 79, 2015 - Issue 2 | https://www.tandfonline.com/doi/full/10.1080/09168451.2014.955454 | ||||||||||||||||||||||||
10 | Immunomodulatory effect of Stichopus japonicus acid mucopolysaccharide on experimental hepatocellular carcinoma in rats. | 日本刺參 (Stichopus japonicus) 中的酸粘多醣 (Mucopolysaccharide )對老鼠實驗性肝癌細胞的免疫調節作用 | Molecules 2013, 18(6), 7179-7193 | https://www.mdpi.com/1420-3049/18/6/7179 | ||||||||||||||||||||||||
11 | Structure of cucumarioside I2 from the sea cucumber Eupentacta fraudatrix (Djakonov et Baranova) and cytotoxic and immunostimulatory activities of this saponin and relative compounds | 海參 (Eupentacta fraudatrix) 中皂苷 (Cucumarioside I2) 的結構以及該皂苷和相關化合物的細胞毒性和免疫刺激活性 | Natural Product Research. Volume 27, 2013 - Issue 19 | https://www.tandfonline.com/doi/abs/10.1080/14786419.2013.778851 | ||||||||||||||||||||||||
12 | Immunomodulatory Properties of Frondoside A, a Major Triterpene Glycoside from the North Atlantic Commercially Harvested Sea Cucumber Cucumaria frondosa | 北大西洋採伐的海參 (Cucumaria frondosa) 中的主要三萜糖苷(Frondoside A)的免疫調節特性 | Journal of Medicinal Food. 2008 Sep;11(3):443-53 | https://www.liebertpub.com/doi/pdf/10.1089/jmf.2007.0530 | ||||||||||||||||||||||||
13 | Antidiabetic & Glucose Lowering Activity | 海參對抗糖尿病和降低葡萄糖活性的保健 | Anti-diabetic activity of Holothuria thomasi saponin | 海參 (Holothuria thomasi) 中皂苷的抗糖尿病活性 | Biomedicine & Pharmacotherapy. Volume 84, December 2016, Pages 1472-1487 | https://www.sciencedirect.com/science/article/abs/pii/S0753332216310356?via%3Dihub | ||||||||||||||||||||||
14 | Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4. | 海參 (Cucumaria frondosa) 中的褐藻糖膠 (Fucoidan) 通過激活PI3K / PKB途徑和GLUT4在胰島素抵抗老鼠中表現出抗高血糖功效 | Journal of Bioscience & Bioengineering. 2016 Jan;121(1):36-42 | https://www.sciencedirect.com/science/article/pii/S1389172315002054?via%3Dihub | ||||||||||||||||||||||||
15 | Fucosylated Chondroitin Sulfate from Sea Cucumber Improves Insulin Sensitivity via Activation of PI3K/PKB Pathway | 海參中的岩藻糖基硫酸軟骨素 (Fucosylated Chondroitin Sulfate) 通過激活PI3K / PKB途徑改善胰島素敏感性 | Journal of Food Science. 2014 Jul;79(7):H1424-9. | https://onlinelibrary.wiley.com/doi/pdf/10.1111/1750-3841.12465 | ||||||||||||||||||||||||
16 | Eicosapentaenoic acid-enriched phosphatidylcholine isolated from Cucumaria frondosa exhibits anti-hyperglycemic effects via activating phosphoinositide 3-kinase/protein kinase B signal pathway | 從海參 (Cucumaria frondosa) 中分離的富含二十碳五烯酸的磷脂酰膽鹼(Eicosapentaenoic Acid-Enriched Phosphatidylcholine) 通過激活磷酸肌醇3-激酶/蛋白激酶B信號通路顯示出抗高血糖作用 | Journal Biosci Bioeng. 2014 Apr;117(4):457-63 | https://www.sciencedirect.com/science/article/pii/S1389172313003460?via%3Dihub | ||||||||||||||||||||||||
17 | Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance in high-fat diet-fed mice. | 海參的膳食皂苷改善高脂肪飲食飼養老鼠的肥胖，肝脂肪變性和葡萄糖不耐受症狀 | Journal of Medicinal Food. 2012 Oct;15(10):909-16. | https://www.ncbi.nlm.nih.gov/pubmed/22897583 | ||||||||||||||||||||||||
18 | Antihyperlipidemic | 降血脂 | Saponins of sea cucumber attenuate atherosclerosis in ApoE−/− mice via lipid-lowering and anti-inflammatory properties | 海參皂苷通過降脂和抗炎特性減輕ApoE - / - 老鼠的動脈粥狀硬化 | Journal of Functional Foods. Volume 48, September 2018, Pages 490-497 | https://www.sciencedirect.com/science/article/pii/S1756464618303815 | ||||||||||||||||||||||
19 | Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate | 岩藻糖 (Fucose) 分支的硫酸化模式改變岩藻糖基化硫酸軟骨素 (Fucosylated Chondroitin Sulfate) 的抗高血脂活性 | Carbohydrate Polymers. Volume 147, 20 August 2016, Pages 1-7 | https://www.sciencedirect.com/science/article/pii/S0144861716301886?via%3Dihub | ||||||||||||||||||||||||
20 | Inhibitory effect of fucosylated chondroitin sulfate from the sea cucumber Acaudina molpadioides on adipogenesis is dependent on Wnt/β-catenin pathway | 海參 (Acaudina molpadioides) 中岩藻糖基硫酸軟骨素 (Fucosylated Chondroitin Sulfate) 對於脂肪形成的抑製功效是依賴於Wnt /β-catenin途徑 | Journal of Bioscience and Bioengineering. Volume 119, Issue 1, January 2015, Pages 85-91 | https://www.sciencedirect.com/science/article/pii/S1389172314002126?via%3Dihub | ||||||||||||||||||||||||
21 | Effects of Bioactive Components of Sea Cucumber on the Serum, Liver Lipid Profile and Lipid Absorption | 海參生物活性成分對血清，肝臟脂肪組合和脂肪吸收的影響 | Bioscience, Biotechnology, and Biochemistry. Volume 76, 2012 - Issue 12 | https://www.tandfonline.com/doi/abs/10.1271/bbb.120495 | ||||||||||||||||||||||||
22 | Antioxidant and antihyperlipidemic activities of polysaccharides from sea cucumber Apostichopus japonicus | 日本刺參 (Apostichopus japonicus) 中多醣的抗氧化和抗高血脂活性 | Carbohydrate Polymers. Volume 90, Issue 4, 6 November 2012, Pages 1664-1670 | https://www.sciencedirect.com/science/article/pii/S0144861712007205?via%3Dihub | ||||||||||||||||||||||||
23 | Hypolipidemic effect of glycosaminoglycans from the sea cucumber Metriatyla scabra in rats fed a cholesterol-supplemented diet. | 海參 (Metriatyla scabra) 的糖胺聚醣 (Glycosaminoglycans) 對餵飼膽固醇餐單老鼠的降血脂作用 | Journal of Agric Food Chem. 2002 Jun 5;50(12):3602-6. | https://www.ncbi.nlm.nih.gov/pubmed/12033836 | ||||||||||||||||||||||||
24 | Nutritional value of Holothuria forskali protein and effects on serum lipid profile in rats. | 海參 (Holothuria forskali) 蛋白的營養價值及對老鼠血脂組的影響 | Journal of Physiol Biochem. 2000 Mar;56(1):39-43. | https://www.ncbi.nlm.nih.gov/pubmed/10879680 | ||||||||||||||||||||||||
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26 | Anticoagulant & Antithrombotic | 抗凝血和抗血栓形成 | Primary structure and anticoagulant activity of fucoidan from the sea cucumber Holothuria polii | 海參 (Holothuria polii) 中褐藻糖膠 (Fucoidan)的一級結構和抗凝血活性 | International Journal of Biological Macromolecules. Volume 121, January 2019, Pages 1145-1153 | https://www.sciencedirect.com/science/article/pii/S0141813018329659 | ||||||||||||||||||||||
27 | Basic and clinical study on the antithrombotic mechanism of glycosaminoglycan extracted from sea cucumber | 海參提取的糖胺聚醣對抗血栓形成的機制基礎及臨床研究 | Chinese medical journal 113(8):706-11. September 2000 | https://www.researchgate.net/publication/11582069_Basic_and_clinical_study_on_the_antithrombotic_mechanism_of_glycosaminoglycan_extracted_from_sea_cucumber | ||||||||||||||||||||||||
28 | Blood Pressure | 海參對血壓的保健 | Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Hypertensive Effect of Protein Hydrolysate from Actinopyga lecanora (Sea Cucumber) in Rats | 海參 (Actinopyga lecanora）中蛋白質水解產物對老鼠體內的血管緊張素轉換酶（ACE）抑制以及抗高血壓作用 | Marine Drugs. 2016 Oct; 14(10): 176. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082324/ | ||||||||||||||||||||||
29 | Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Oxidant Activities of Sea Cucumber (Actinopyga lecanora) Hydrolysates | 海參 (Actinopyga lecanora）中水解產物對抑制血管緊張素轉換酶（ACE）的抑制性及抗氧化活性 | International Journal of Molecular Science 2015, 16(12), 28870-28885 | https://www.mdpi.com/1422-0067/16/12/26140 | ||||||||||||||||||||||||
30 | Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate | 海參中明膠水解物的降壓作用及ACE抑制肽的純化 | Process Biochemistry. Volume 42, Issue 12, December 2007, Pages 1586-1591 | https://www.sciencedirect.com/science/article/pii/S1359511307002346 | ||||||||||||||||||||||||
31 | Skin | 海參對肌膚的保健 | Effect of Low Molecular Weight Oligopeptides Isolated from Sea Cucumber on Diabetic Wound Healing in db/db Mice | 海參中分離的低分子質量寡肽對db / db老鼠的糖尿病傷口癒合能力的影響 | Marine Drugs. 2018 Jan; 16(1): 16. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793064/ | ||||||||||||||||||||||
32 | Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber | 煮沸海參中液體提取物的的糖蛋白組分對皮膚美白和抗皺紋的活性研究 | Asian Pacific Journal of Tropical Medicine, October 2016, Pages 1002-1006 | https://www.sciencedirect.com/science/article/pii/S1995764516301626 | ||||||||||||||||||||||||
33 | Wound healing activity of total sulfated glycosaminoglycan (GAG) from Stichopus vastus and Stichopus hermanni integumental tissue in rats. | 兩種刺參（Stichopus vastus 和Stichopus hermanni）中總硫酸化糖胺聚醣（Sulfated Glycosaminoglycan (GAG) ) 對老鼠外周組織傷口癒合的活性研究 | International Journal of Molecular Medicine Advance Science 2010, 6 (4):49-53 | http://www.medwelljournals.com/abstract/?doi=ijmmas.2010.49.53 | ||||||||||||||||||||||||
34 | Gastrointestinal | 海參對胃腸道的保健 | Ameliorative effect of the sea cucumber Holothuria arenicola extract against gastric ulcer in rats | 海參 (Holothuria arenicola) 中提取物對胃潰瘍老鼠的改善作用 | The Journal of Basic & Applied Zoology. Volume 72, October 2015, Pages 16-25 | https://www.sciencedirect.com/science/article/pii/S2090989615000223 | ||||||||||||||||||||||
35 | Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage | 海參（Acaudina molpadioides）內褐藻糖膠 (Fucoidan) 對乙醇誘導胃損傷的保護作用 | Food Chemistry. Volume 133, Issue 4, 15 August 2012, Pages 1414-1419 | https://www.sciencedirect.com/science/article/pii/S0308814612002154 | ||||||||||||||||||||||||
36 | Antimicrobial & Antiviral | 抗菌和抗病毒 | Fucosylated Chondroitin Sulfate Inhibits Plasmodium falciparum Cytoadhesion and Merozoite Invasion | 岩藻糖基硫酸軟骨素 (Fucosylated Chonfroitin Sulfate) 能抑制惡性瘧原蟲 (Plasmodium falciparum) 細胞粘附和裂殖子入侵 | Antimicrobial Agents Chemotherapy. 2014 Apr; 58(4): 1862–1871. | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023758/ | ||||||||||||||||||||||
37 | Antibacterial, antifungal and cytotoxic effects of a sea cucumber Holothuria leucospilota, from the north coast of the Persian Gulf | 波斯灣北岸的海參 (Holothuria leucospilota) 的抗菌，抗真菌和細胞毒性作用研究 | Journal of the Marine Biological Association of the United Kingdom. Volume 93, Issue 5 | https://www.cambridge.org/core/journals/journal-of-the-marine-biological-association-of-the-united-kingdom/article/antibacterial-antifungal-and-cytotoxic-effects-of-a-sea-cucumber-holothuria-leucospilota-from-the-north-coast-of-the-persian-gulf/64602FE9EA136D6BE31E96258AC89B20 | ||||||||||||||||||||||||
38 | The effect of eating sea cucumber jelly on Candida load in the oral cavity of elderly individuals in a nursing home. | 食用海參果凍對養老院老年人口腔念珠菌 (Candida) 數量的影響 | Marine Drugs 2013, 11(12), 4993-5007 | https://www.mdpi.com/1660-3397/11/12/4993 | ||||||||||||||||||||||||
39 | Hemolytic C-Type Lectin CEL-III from Sea Cucumber Expressed in Transgenic Mosquitoes Impairs Malaria Parasite Development | 海參的溶血性C型凝集素CEL-III (Hemolytic C-Type Lectin CEL-III) 基因當表達在轉基因蚊子後能削弱瘧疾寄生蟲發育 | PLOS Pathogen, December 21, 2007 | https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.0030192 | ||||||||||||||||||||||||
40 | Anti-Inflammatory | 海參對抗炎的保健 | Anti-proliferative and anti-inflammatory activities of the sea cucumber Holothuria polii aqueous extract | 海參 (Holothuria polii) 水提取物的抗增生及抗炎活性研究 | SAGE Open Med. 2018; | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236865/ | ||||||||||||||||||||||
41 | Sea cucumber (Isostichopus badionotus) body-wall preparations exert anti-inflammatory activity in vivo | 海參（Isostichopus badionotus）體壁製劑能在體內研究中發揮抗炎效用 | PharmaNutrition. Volume 6, Issue 2, June 2018, Pages 74-80 | https://www.sciencedirect.com/science/article/pii/S2213434418300264 | ||||||||||||||||||||||||
42 | Structural comparison, antioxidant and anti-inflammatory properties of fucosylated chondroitin sulfate of three edible sea cucumbers | 三種食用海參中岩藻糖基硫酸軟骨素 (Fucosylated Chondroitin Sulfate)的結構對比，抗氧化和抗炎特性研究 | Carbohydrate Polymers. Volume 185, 1 April 2018, Pages 41-47 | https://www.sciencedirect.com/science/article/pii/S0144861718300171 | ||||||||||||||||||||||||
43 | Evaluation of cytotoxicity and anti-inflammatory effects of saponin isolated from Holothuria leucospilota Sea cucumber | 海參 (Holothuria leucospilota) 皂苷對細胞毒性和抗炎作用研究 | Journal of Cellular Immunotherapy. Volume 1, Issues 1–2, December 2015, Pages 17-18 | https://www.sciencedirect.com/science/article/pii/S2352177515000230 | ||||||||||||||||||||||||
44 | Neuroprotective （Brain & Nervous System Health Effect of Sea Cucumber） | 神經保護 | Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota | 海參（Holothuria leucospilota）中提取的生物活性物質對抗帕金森症的活研究 | Biomedicine & Pharmacotherapy. Volume 109, January 2019, Pages 1967-1977 | https://www.sciencedirect.com/science/article/pii/S0753332218363923 | ||||||||||||||||||||||
45 | Protective effects of cerebrosides from sea cucumber and starfish on the oxidative damage in PC12 cells. | 海參和海星內的腦苷脂在遭受氧化傷害的PC12細胞上的保護作用研究 | Journal Oleo Sci. 2013;62(9):717-27. | https://www.ncbi.nlm.nih.gov/pubmed/24005016 | ||||||||||||||||||||||||
46 | Anti-fatigue | 抗疲勞 | The potency of sandfish (holothuria scraba) as a source of natural aphrodisiacs. | 沙魚（Holothuria scraba）作為天然催情劑的效力研究 | World Academy of Science, Engineering and Technology 2013 Vol77. | http://waset.org/publications/9996642 | ||||||||||||||||||||||
47 | Anti-fatigue Effect of Sea Cucumber Stichopus japonicus in Mice | 刺參 (Stichopus japonicus) 對老鼠的抗疲勞作用 | Food science 2010, 31(15): 244-247 | http://en.cnki.com.cn/Article_en/CJFDTOTAL-SPKX201015055.htm | ||||||||||||||||||||||||
48 | Cancer | 抗癌 | Isolation of sphingoid bases of sea cucumber cerebrosides and their cytotoxicity against human colon cancer cells. | 海參腦脂醣苷 (Cerebrosides) 中鞘神經鞘氨醇基 (Cphingoid bases)的分離方法及其對人類結腸癌細胞的殺傷作用 | Bioscience, Biotechnology & Biochemistry 2006, 70: 2906-2912 | https://www.tandfonline.com/doi/pdf/10.1271/bbb.60318 | ||||||||||||||||||||||
49 | Triterpene Glycosides from Sea Cucumber Holothuria scabra with Cytotoxic Activity | 海參 (Holothuria scabra)中的三萜糖苷 (Triterpene Glycosides) 的細胞毒性研究 | Chinese Herbal Medicines | https://www.sciencedirect.com/science/article/pii/S1674638412600148 | ||||||||||||||||||||||||
50 | PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. | PE, 一種來自海參的新型硫酸化皂苷 (Sulfated Saponin)，均在體外和體內研究呈現抗血管生成和抗腫瘤活性 | Volume 4, Issue 3, August 2012, Pages 183-188 | https://www.researchgate.net/publication/7678297_PE_a_new_sulfated_saponin_from_sea_cucumber_Exhibits_anti-angiogenic_and_anti-tumor_activities_in_vitro_and_in_vivo | ||||||||||||||||||||||||
51 | Joint & Bone Health Effect of Sea Cucumber | 海參對關節及骨骼系統的功用 | Sea cucumber : a natural arthritis treatment | 海參：天然關節炎治療方案 | https://www.dynamicchiropractic.com/mpacms/dc/article.php?id=39116 | |||||||||||||||||||||||
52 | Kidney Health Effect of Sea Cucumber | 海參對腎臟系統的功用 | ||||||||||||||||||||||||||
53 | The potency of sandfish (holothuria scraba) as a source of natural aphrodisiacs. | 沙魚（Holothuria scraba）作為天然催情劑的效力研究 | World Academy of Science, Engineering and Technology 2013 Vol77. | http://waset.org/publications/9996642 | ||||||||||||||||||||||||
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55 | Metabolic Health Effect of Sea Cucumber | 海參對身體新陳代謝的的功用 | Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance. | 海參中膳食皂苷可改善肥胖，肝臟脂肪變性和葡萄糖耐受不良 | Med Food 2012 Oct, 15(10):909-916 | https://www.ncbi.nlm.nih.gov/pubmed/22897583 | ||||||||||||||||||||||
56 | Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose metabolism in obese mice. | 海參腦苷脂 (Cerebroside) 及其長鏈鹼對肥胖老鼠體內的脂糖代謝影響 | Zhejiang Uni. (Med. Sc) 01/2012, 41(1):60-4 | http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_zjdxxb-yxb201201010 | ||||||||||||||||||||||||
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59 | Cardiovascular Health Effect of Sea Cucumber | 海參對心臟及血管健康的功用 | ||||||||||||||||||||||||||
60 | Brain & Nervous System Health Effect of Sea Cucumber | 海參對腦&神經系統的保健 | ||||||||||||||||||||||||||
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