| A | B | C | D | E | |
|---|---|---|---|---|---|
1 | Scenario | Conservative | Best guess | Optimistic | Sources |
2 | Average reduction in GAD-7 score per participant | 1 | 4 | 6 | MindEase internal evaluation |
3 | Disability weight of 1 point on GAD-7 scale | 0.001 | 0.04 | 0.15 | Studies showing concomitant GAD-7 score reductions and QALY improvements |
4 | DALYs averted per year per participant directly post-treatment | 0.00 | 0.17 | 0.92 | Calculation |
5 | Retention rate of benefits | 50% | 84% | 86% | Long-term Outcomes of Cognitive Behavioral Therapy for Anxiety-Related Disorders |
6 | Total DALYs averted per user | 0.002 | 1 | 6.11 | Calculation |
7 | ME alternative GAD-7 reduction | 1 | 3 | 2 | Independent eval. of Pacifica competitor app shows 3 point reduction |
8 | Counterfactual GAD-7 reduction | 0.05 | 1 | 4 | Calculation (Row 2 - Row 7) |
9 | Counterfactual adjustment: how much extra effect does ME have? | 5% | 25% | 67% | Calculation |
10 | Counterfactual DALYs averted per user | 0.0001 | 0.25 | 4.07 | |
11 | Cost per beneficiary | $54 | $1.2 | $1.2 | MindEase cost-per-user |
12 | Cost per DALY averted | $528,000 | $4.8 | $0.3 | Calculation |
13 | Cost per equivalent of a year of severe anxiety disorder prevented | $276,144 | $3 | $0.2 | Calculation |
14 | Cost per DALY averted equivalent of Givewell charities | $14 | $835 | $2,770 | Deworming, Cash-transfers, Action for Happiness |
15 | Health: MindEase is x times more effective than global development interventions | 0.003% | 172 | 9,396 | Calculation |