Phenotypic annotations from Cryptococcus RO3 Project: Version 2016-08-18
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Gene IDPubMedModificationAllelePhenotypeFurther Information
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CNAG_0002520889719N/AN/Acapsule formation: normalcapsule formation: normal
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CNAG_0002520889719N/AN/Agrowth at host temperature: decreasedat 35 deg in the presence of cyclosporin A
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CNAG_0002520889719N/AN/Aresistance to calcium : decreasedat 30 deg in the presence of cyclosporin A
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CNAG_0002523895559N/AN/Aresistance to calcium : decreasedcalcium(2+) (400 mM)
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CNAG_0002520889719N/AN/Aresistance to phagocytosis: increasedresistance to phagocytosis: increased
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CNAG_0002520889719N/AN/Avirulence: decreasedmouse pulmonary infection
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CNAG_0003621453402N/Asec14-2::NATviableviable
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CNAG_0004022155829
reduction of function
erg11-Y145Fresistance to fluconazole: increasedfluconazole (MIC 128 ug/ml)
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CNAG_0004022155829
reduction of function
erg11-Y145Fresistance to itraconazole: decreaseditraconazole (MIC 0.38 ug/ml)
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CNAG_0004022155829
reduction of function
erg11-Y145Fresistance to posaconazole: decreasedresistance to posaconazole: decreased
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CNAG_0004022155829
reduction of function
erg11-Y145Fresistance to voriconazole: increasedresistance to voriconazole: increased
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CNAG_0005118854164N/AN/Acapsule formation: normal
10% Sabouraud medium buffered to pH 7.3 with 50 mM MOPS, grown at 30 deg C for two days then stained with India ink
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CNAG_0005118854164N/AN/Acompetitive fitness: decreased
decreased survival in mouse lungs assayed in pools of 48 STM mutants
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CNAG_0009720689743N/AN/Avirulence: normalmouse pulmonary infection
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CNAG_0010616672377N/AN/Aviableviable
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CNAG_0012512933823N/AN/Amating response: increasedmating response: increased
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CNAG_0012515302835N/AN/Amating response: increased
increased formation of conjugation tubes upon pheromone treatment
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CNAG_0012515302835N/AN/Avirulence: increasedmouse pulmonary infection
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CNAG_0013018854164N/AN/Acapsule formation: normal
10% Sabouraud medium buffered to pH 7.3 with 50 mM MOPS, grown at 30 deg C for two days then stained with India ink
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CNAG_0013021533251N/AN/Acapsule formation: normalcapsule formation: normal
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CNAG_0013018854164N/AN/Acompetitive fitness: increased
increased survival in mouse lungs assayed in pools of 48 STM mutants
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CNAG_0013021533251N/AN/Amelanin production: normalmelanin production: normal
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CNAG_0013021533251N/AN/Aresistance to fludioxonil: increasedfludioxonil (10, 30, 40 ug/ml)
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CNAG_0013021533251N/AN/Avirulence: normalmouse pulmonary infection
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CNAG_0015018854164N/AN/Avirulence: normalmouse pulmonary infection
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CNAG_0015621487010N/AN/Acapsule formation: increasedcapsule formation: increased
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CNAG_0015623251520N/Acrz1::NEOcapsule formation: normal
72 h incubation at 37 deg C in RPMI medium with 5% CO2 | examined by differential interference microscopy after and staining with India ink
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CNAG_0015623251520N/Acrz1::NEOhyperosmotic stress resistance: normalYPD with 1 M NaCl, 30 deg C
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CNAG_0015621487010N/AN/Alaccase activity: decreasedlaccase activity: decreased
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CNAG_0015623251520N/Acrz1::NEOmating projection morphology: normalV8 mating agar
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CNAG_0015623251520N/Acrz1::NEOmelanin production: normalL-DOPA plates containing 0.1% glucose
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CNAG_0015623251520N/Acrz1::NEOresistance to calcium chloride: normalYPD with 400 mM CaCl2, 30 deg C
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CNAG_0015621487010N/AN/Aresistance to Calcofluor White: decreasedCalcofluor White (0.5 mg/ml)
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CNAG_0015623251520N/Acrz1::NEOresistance to Calcofluor White: decreased0.5 mg/ml
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CNAG_0015621487010N/AN/Aresistance to Congo Red: decreasedCongo Red (0.5%)
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CNAG_0015623251520N/Acrz1::NEOresistance to Congo Red: decreasedCongo Red (0.1%)
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CNAG_0015621487010N/AN/Avirulence: decreasedmouse intravenous infection
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CNAG_0016214500501N/AN/Aresistance to killing by host cells: decreasedgamma interferon- and LPS-stimulated macrophages
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CNAG_0016214500501N/AN/Avirulence: decreasedmouse pulmonary infection
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CNAG_0016214500501N/AN/Avirulence: normal
other model (inocculation into cisternae magnae of immunosuppressed rabbits)
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CNAG_0018118854164N/AN/Acompetitive fitness: decreased
decreased survival in mouse lungs assayed in pools of 48 STM mutants
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CNAG_0019321441208N/AN/Acapsule formation: decreasedcapsule formation: decreased
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CNAG_0019320673806N/AN/Acapsule formation: normalcapsule formation: normal
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CNAG_0019320673806N/AN/Acapsule production: normalcapsule production: normal
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CNAG_0019320673806N/AN/Agrowth at host temperature: normalgrowth at host temperature: normal
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CNAG_0019321441208N/AN/Aheat sensitivity: decreased40 deg
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CNAG_0019321441208N/AN/Amating response: increased
enhanced filamentation and production of basidia in both unilateral and bilateral crosses
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CNAG_0019321441208N/AN/Amelanin production: increasedmelanin production: increased
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CNAG_0019320673806N/AN/Amelanin production: normalmelanin production: normal
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CNAG_0019320673806N/AN/Aresistance to killing by host cells: normalresistance to killing by host cells: normal
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CNAG_0019320673806N/AN/Asecretion of glucuronoxylomannan: decreasedsecretion of glucuronoxylomannan: decreased
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CNAG_0019320673806N/AN/Autilization of alanine as nitrogen source: decreasedutilization of alanine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of alanine nitrogen source: absentutilization of alanine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of amino acid as nitrogen source: decreasedutilization of amino acid as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of ammonium as nitrogen source: decreasedutilization of ammonium as nitrogen source: decreased
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CNAG_0019321441208N/AN/Autilization of ammonium as nitrogen source: decreasedutilization of ammonium as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of amonium nitrogen source: absentutilization of amonium nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of arginine as nitrogen source: decreasedutilization of arginine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of arginine nitrogen source:decreasedutilization of arginine nitrogen source:decreased
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CNAG_0019320673806N/AN/Autilization of asparagine as nitrogen source: decreasedutilization of asparagine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of asparagine nitrogen source: absentutilization of asparagine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of aspartic acid nitrogen source: absentutilization of aspartic acid nitrogen source: absent
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CNAG_0019320673806N/AN/A
utilization of aspartic acid as nitrogen source: decreased
utilization of aspartic acid as nitrogen source: decreased
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CNAG_0019321441208N/AN/Autilization of creatinine as nitrogen source: decreasedutilization of creatinine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of cysteine as nitrogen source: decreasedutilization of cysteine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of cysteine nitrogen source: absentutilization of cysteine nitrogen source: absent
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CNAG_0019320673806N/AN/A
utilization of glutamic acid as nitrogen source: decreased
utilization of glutamic acid as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of glutamic acid nitrogen source: absentutilization of glutamic acid nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of glutamine as nitrogen source: decreasedutilization of glutamine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of glutamine nitrogen source: absentutilization of glutamine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of glycine as nitrogen source: decreasedutilization of glycine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of glycine nitrogen source: absentutilization of glycine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of histidine as nitrogen source: decreasedutilization of histidine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of histidine nitrogen source: absentutilization of histidine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of isoleucine as nitrogen source: decreasedutilization of isoleucine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of isoleucine nitrogen source: absentutilization of isoleucine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of leucine as nitrogen source: decreasedutilization of leucine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of leucine nitrogen source: absentutilization of leucine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of lysine as nitrogen source: decreasedutilization of lysine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of lysine nitrogen source: decreasedutilization of lysine nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of methionine nitrogen source: absentutilization of methionine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of phenylaanine nitrogen source: absentutilization of phenylaanine nitrogen source: absent
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CNAG_0019320673806N/AN/A
utilization of phenylalanine as nitrogen source: decreased
utilization of phenylalanine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of proline as nitrogen source: decreasedutilization of proline as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of proline nitrogen source: decreasedutilization of proline nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of serine as nitrogen source: decreasedutilization of serine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of serine nitrogen source: absentutilization of serine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of threonine nitrogen source: absentutilization of threonine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of threonine nitrogen source: decreasedutilization of threonine nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of tryptophan as nitrogen source: decreasedutilization of tryptophan as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of tryptophan nitrogen source: absentutilization of tryptophan nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of tyrosine as nitrogen source: decreasedutilization of tyrosine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of tyrosine nitrogen source: absentutilization of tyrosine nitrogen source: absent
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CNAG_0019320673806N/AN/Autilization of urea as nitrogen source: decreasedutilization of urea as nitrogen source: decreased
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CNAG_0019321441208N/AN/Autilization of urea as nitrogen source: decreasedutilization of urea as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of urea nitrogen source: absentutilization of urea nitrogen source: absent
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CNAG_0019321441208N/AN/Autilization of uric acid as nitrogen source: decreasedutilization of uric acid as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of valine as nitrogen source: decreasedutilization of valine as nitrogen source: decreased
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CNAG_0019320673806N/AN/Autilization of valine nitrogen source: absentutilization of valine nitrogen source: absent
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