BioSci – Combined_Stage_Milestones
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1
Deal Size ($M)% of Deal SizeUpfront Cash ($M)% of UpfrontTotal Dev/RegIND FilingPh I StartPh II StartPh III StartPh III % of TotalFDA FilingFDA ApprovalFDA % of TotalEU FilingMajor EU ApprovalJapan FilingJapan+ Approval
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3
All AverageN=1073$107.8728.7%$11.53268.6%$30.97$1.40$1.86$3.79$5.7618.6%$7.87$12.8641.5%$6.84$11.13$4.06$6.52
4
Median$27.7043.3%$2.30521.7%$12.00$0.75$0.75$1.50$2.5020.8%$4.00$5.0041.7%$5.00$5.00$3.00$5.00
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6
All III AverageN=153$189.9022.8%$27.32158.6%$43.34$18.82$29.7068.5%$9.75$16.98$3.88$6.17
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Median$74.2023.6%$10.00175.0%$17.50$10.00$15.0085.7%$5.00$10.00$2.50$4.95
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9
All III AverageN=40$258.0818.4%$35.46134.1%$47.55$25.51$28.7360.4%$16.98$29.58$5.39$8.14
10
2008+ Median$89.5527.9%$8.63289.7%$25.00$16.05$25.00100.0%$5.00$11.75$5.00$3.50
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All III AverageN=55$165.8627.5%$26.41172.6%$45.59$18.58$34.1374.9%$7.72$14.48$3.78$6.24
13
2004-07 Median$100.0029.0%$22.50128.9%$29.00$10.00$20.0069.0%$5.40$10.85$2.90$5.00
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15
All III AverageN=35$216.3223.2%$26.47189.7%$50.22$20.93$34.6268.9%$6.58$11.47$2.60$4.94
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2001-03 Median$38.0033.2%$5.95211.8%$12.60$7.00$7.0055.6%$5.25$10.00$2.50$4.00
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18
All III AverageN=23$88.5822.7%$15.35131.3%$20.15$8.83$13.7868.4%$5.38$6.89$1.00$2.00
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1998-00 Median$55.0027.3%$5.00300.0%$15.00$5.13$13.7591.7%$5.00$6.50$1.00$2.00
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21
All II AverageN=176$179.2324.5%$19.61224.0%$43.92$10.3723.6%$8.81$17.7540.4%$8.83$15.00$4.70$10.26
22
Median$54.2036.9%$6.00333.3%$20.00$5.0025.0%$5.00$8.0040.0%$5.00$7.00$5.00$5.00
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All II AverageN=54$276.1923.5%$29.11223.0%$64.91$15.1223.3%$12.04$31.8149.0%$10.83$20.29$6.07$16.15
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2008+ Median$118.8025.1%$15.00199.0%$29.85$5.0016.8%$10.00$15.0050.3%$10.00$13.50$5.00$10.00
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All II AverageN=71$188.5125.0%$19.54241.2%$47.14$10.8823.1%$9.62$16.1934.3%$9.90$17.11$3.56$6.96
28
2004-07 Median$63.0031.7%$8.75228.6%$20.00$5.0025.0%$5.00$6.5032.5%$6.00$10.00$3.00$5.00
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All II AverageN=28$70.2024.8%$7.01248.1%$17.39$4.1623.9%$4.39$8.2047.2%$2.34$3.72$2.67$2.90
31
2001-03 Median$17.5044.3%$1.90407.9%$7.75$2.0025.8%$3.00$4.0051.6%$2.00$2.00$2.00$3.50
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33
All II AverageN=23$55.6430.6%$15.00113.5%$17.03$5.2130.6%$5.16$6.3837.5%$3.17$4.25$4.50$5.25
34
1998-00 Median$35.0045.7%$4.00400.0%$16.00$3.0018.8%$4.50$5.0031.3%$3.50$4.00$4.50$5.00
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36
All I AverageN=88$144.4732.9%$13.73346.0%$47.51$9.38$7.8816.6%$9.27$18.1338.2%$7.28$12.59$4.67$7.65
37
Median$53.0045.8%$5.00485.0%$24.25$5.00$4.0016.5%$5.00$10.0041.2%$5.00$7.50$2.00$5.00
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39
All I AverageN=21$249.9229.9%$23.33320.7%$74.82$21.96$10.6814.3%$15.73$24.5932.9%$12.86$19.96$6.86$10.19
40
2008+ Median$71.5037.8%$7.00385.7%$27.00$8.00$6.0022.2%$10.00$16.5061.1%$10.00$17.50$5.00$5.00
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42
All I AverageN=41$113.4635.3%$9.36428.1%$40.07$4.82$7.3818.4%$8.12$16.4641.1%$5.98$12.11$4.38$6.22
43
2004-07 Median$47.0042.6%$4.75421.1%$20.00$4.00$4.0020.0%$5.00$10.0050.0%$5.00$6.25$2.50$5.00
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45
All I AverageN=12$130.6629.7%$16.78231.3%$38.81$7.78$6.2016.0%$5.31$17.4545.0%$4.50$9.17#DIV/0!$12.50
46
2001-03 Median$57.3341.9%$8.00300.0%$24.00$4.00$3.0012.5%$5.00$10.0041.7%$4.50$5.00#NUM!$12.50
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48
All I AverageN=14$88.9640.3%$10.38345.1%$35.82$5.86$6.6018.4%$6.11$13.5037.7%$4.07$7.74$2.52$5.51
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1998-00 Median$65.3036.0%$6.50361.5%$23.50$5.00$4.0017.0%$5.00$8.0034.0%$4.20$5.00$2.00$4.25
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51
All Preclin AverageN=266$70.1337.6%$4.49586.6%$26.34$1.66$2.16$3.91$5.3320.2%$5.23$8.8133.4%$5.26$8.53$4.49$5.55
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Median$20.8045.4%$1.00945.0%$9.45$0.75$0.75$2.00$3.0031.7%$2.50$5.0052.9%$3.00$5.00$3.00$4.30
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54
All Preclin AverageN=83$106.1635.5%$5.66665.4%$37.66$2.75$2.10$4.65$6.9918.6%$5.96$12.1132.2%$7.84$11.60$8.33$5.96
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2008+ Median$38.1031.5%$1.001200.0%$12.00$1.00$0.50$2.00$4.0033.3%$3.00$5.0041.7%$9.50$10.00$5.00$5.00
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All Preclin AverageN=101$73.6136.6%$5.31507.0%$26.92$1.34$2.85$4.62$5.6621.0%$5.82$8.4931.5%$5.21$7.52$3.34$5.61
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2004-07 Median$19.3049.2%$1.00950.0%$9.50$0.50$0.50$1.50$2.9030.5%$2.50$5.0052.6%$3.00$4.10$2.50$4.75
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60
All Preclin AverageN=47$35.1050.0%$2.57682.9%$17.55$0.71$1.59$2.01$3.3619.1%$4.13$7.5042.7%$3.31$4.70$3.50$4.61
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2001-03 Median$23.5042.6%$1.50666.7%$10.00$0.43$1.00$1.00$2.0020.0%$4.00$5.0050.0%$2.75$4.00$2.00$3.00
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63
All Preclin AverageN=35$20.2947.4%$1.73555.5%$9.61$1.08$0.79$1.52$2.1722.6%$2.50$3.6437.9%$1.40$3.95$1.50$3.76
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1998-00 Median$15.6344.8%$1.00700.0%$7.00$1.00$0.75$2.00$2.0028.6%$1.13$3.0042.9%$0.50$4.50$1.00$4.00
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66
All Lead AverageN=144$45.1034.2%$3.89396.7%$15.43$0.90$1.48$1.80$2.9319.0%$4.18$6.2240.3%$4.46$6.44$2.38$4.12
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Median$6.6651.8%$0.48718.8%$3.45$0.13$0.50$0.40$1.0029.0%$2.00$2.0058.0%$3.00$4.00$2.00$2.00
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69
All Lead AverageN=33$72.2928.7%$5.69365.2%$20.78$1.71$2.03$1.78$3.3115.9%$5.20$8.9543.1%$8.35$10.76#DIV/0!$5.86
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2008+ Median$4.4849.1%$0.25880.0%$2.20$0.05$0.18$0.15$0.3515.9%$0.50$1.1351.4%$10.00$10.00#NUM!$4.75
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72
All Lead AverageN=44$49.2440.3%$4.91403.9%$19.83$0.85$1.75$2.38$3.9820.1%$5.99$7.1936.3%$3.72$5.52$2.50$4.20
73
2004-07 Median$9.0954.2%$0.90547.8%$4.93$0.13$0.63$0.40$2.5050.7%$4.00$2.5050.7%$3.00$5.00$2.00$3.00
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75
All Lead AverageN=34$32.4832.7%$2.53420.2%$10.63$0.67$0.89$1.35$2.2521.2%$2.63$3.7835.6%$4.92$6.00$2.67$2.90
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2001-03 Median$5.0042.6%$0.63338.1%$2.13$0.05$0.75$0.50$0.7635.7%$1.50$1.2558.7%$3.25$3.25$2.50$1.00
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78
All Lead AverageN=33$24.8037.0%$1.88487.8%$9.17$0.80$0.74$1.07$1.8920.6%$2.55$4.2246.0%$1.84$3.59$1.00$3.29
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1998-00 Median$12.5455.8%$0.501400.0%$7.00$0.50$0.38$0.88$1.5021.4%$2.00$2.2532.1%$0.40$3.50$1.00$2.00
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81
All Disc AverageN=246$69.8531.8%$6.44344.9%$22.21$1.45$1.77$2.85$3.7116.7%$5.15$7.9035.6%$4.66$7.44$2.62$4.72
82
Median$23.2140.2%$1.45643.4%$9.33$1.00$1.00$1.50$2.0021.4%$3.00$4.0042.9%$2.75$4.00$2.00$3.00
83
84
All Disc AverageN=42$148.2224.4%$13.01278.2%$36.20$2.25$2.90$4.39$6.1116.9%$11.05$14.2739.4%$13.13$15.29$4.53$9.65
85
2008+ Median$20.0542.4%$1.57541.4%$8.50$0.18$0.50$2.00$2.0023.5%$8.75$4.0047.1%$16.40$15.00$4.10$10.00
86
87
All Disc AverageN=65$89.5135.1%$6.99449.6%$31.43$2.04$2.01$3.06$5.2516.7%$7.64$9.8631.4%$5.04$8.86$2.65$5.32
88
2004-07 Median$32.9052.3%$3.00573.3%$17.20$1.00$1.00$2.00$3.0017.4%$5.00$5.0029.1%$4.00$5.50$2.00$3.50
89
90
All Disc AverageN=67$48.3037.2%$4.58392.4%$17.97$1.18$0.98$2.39$2.7015.0%$4.27$7.0339.1%$2.50$3.59$1.17$2.34
91
2001-03 Median$20.6558.1%$1.001200.0%$12.00$0.75$0.75$1.50$2.0016.7%$3.00$5.0041.7%$1.75$3.00$0.75$2.00
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93
All Disc AverageN=72$26.4436.6%$2.90333.4%$9.67$1.00$0.98$1.35$1.8719.3%$2.38$3.2533.6%$2.85$3.05$2.30$2.38
94
1998-00 Median$19.9040.2%$1.05761.9%$8.00$1.00$0.91$1.00$2.0025.0%$2.00$3.0037.5%$2.50$2.75$2.50$2.25
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96
Univ AverageN=179$7.2840.5%$0.75393.3%$2.95$0.21$0.13$0.25$0.5719.3%$0.82$1.3646.1%$2.50$1.97$2.00$1.42
97
Median$1.5366.0%$0.12841.7%$1.01$0.05$0.08$0.10$0.2524.8%$0.30$0.5554.5%$0.20$0.75$0.50$0.41
98
99
Corp AverageN=894$127.7928.6%$13.82264.8%$36.59$1.78$2.48$4.89$6.8618.7%$8.86$15.2941.8%$6.99$11.91$4.11$6.93
100
Median$40.0042.5%$3.97428.2%$17.00$1.00$1.00$2.00$3.0017.6%$5.00$7.5044.1%$5.00$6.00$3.00$5.00
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