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1
Intervention
Cost-effectiveness US $ of 2012/DALY (higher estimate)
Cost-effectiveness US $ of 2012/DALY (lower estimate)
Cost-effectiveness US $ of 2012/DALY (midpoint)
LOG10(midpoint CE)
2
Preventive chemotherapy for onchocerciasis
9990.9542425094
3
Treat severe malaria with artesunate vs quinine
5550.6989700043
4
Salt reduction policy in food
04522.51.653212514
5
Voluntary male circumcision
1010101
6
Add syphilis screen to HIV screen/treat LIC
9990.9542425094
7
Emergency obstetric care
1515151.176091259
8
Pre-hospital ECG vs none MIC
1616161.204119983
9
Screen/treat syphilis LIC
1717171.230448921
10
Detect and treat human African trypanosomiasis
228352.51.720159303
11
Treatment smear positive TB with first-line drugs LIC
64927.51.439332694
12
Cataract surgery670381.579783597
13
Detect and treat visceral leishmaniasis
1818181.255272505
14
Treat malaria with ACT Africa
1834261.414973348
15
PMTCT Option B HIV versus no treatment Africa
2626261.414973348
16
ACE inhibitor versus no medication heart failure no access to treatment
2828281.447158031
17
Cleft lip and palate repair
910858.51.767155866
18
Hernia repair11101561.748188027
19
Intermittent preventive treatment malaria in infants Africa
44222132.328379603
20
Preventive chemotherapy for trachoma
228352.51.720159303
21
Intermittent preventive treatment malaria in pregnancy Africa
4591297.52.47348697
22
Detect and treat leprosy
5050501.698970004
23
Indoor Residual Spraying for malaria Africa
26112691.838849091
24
Comprehensive management malaria (spray+nets+treat) Africa
2811772.51.860338007
25
Treatment smear negative TB first-line drugs LIC
4284631.799340549
26
Hepatitis B vaccination LIC
4797721.857332496
27
Add Xpert to smear to diagnose TB LMIC
50114821.913813852
28
Supply ITNs for malaria Africa
619477.51.889301703
29
Rural trauma hospital
8787871.939519253
30
Home presumptive treatment malaria Africa
9393931.968482949
31
Preventive chemotherapy for schistosomiasis and STHs
1141441142.056904851
32
Prevention of Mother-ToChild Transmission (PMTCT) Option B HIV vs Option A4748 Africa
652511582.198657087
33
Primary prevention of ARF/RHD children with GAS pharyngitis49 135
1351351352.130333768
34
Prevention of Mother-ToChild Transmission (PMTCT) Option A HIV vs no treatment50–53 Africa 26–730
267303782.5774918
35
Add syphilis screen to HIV screen/treat54 UMIC 140
1401401402.146128036
36
Beta-blocker and ACE inhibitor vs no medication heart failure access to treatment3 124–219
124219171.52.234264124
37
Scale up ART to all <350 or all infected5556 S Af 188–256
1882562222.346352974
38
Treat breast cancer MIC57 230
2302302302.361727836
39
*HPV (Human Papillomavirus) vaccination @$50/girl MIC5859 198–296
1982962472.392696953
40
Trauma center60 218–302
2183022602.414973348
41
Treat TB with second-line drugs MIC61 264
2642462642.421603927
42
Screen/treat for syphilis UMIC6254 200–369
200369284.52.454082271
43
Beta-blocker and ACE inhibitor vs no med heart failure no access to treatment3 274
2742742742.437750563
44
Older anti-epileptic drug in primary care MIC63 279
2792792792.445604203
45
Intrapartum care64–66 211–492
211492351.52.545925329
46
Eradicate yaws (detect and treat)67 324
3243243242.51054501
47
PMTCT Option A HIV vs no treatment50 SE Asia 355
3553553552.550228353
48
PMTCT (Eliination of Mother-To-Child Tranmission) Option B+ HIV versus Option A6848 Africa 251–502
251502376.52.575764981
49
Treat colorectal cancer (CRC)69 LIC 430
4304304302.633468456
50
Maintenance psychosocial care for depression primary care70 UMIC 437
4374374372.640481437
51
Non-emergency orthopaedic conditions7172 359–540
359540449.52.652729696
52
BCC plus regulation sex establishments73 LAC 557–570
557570563.52.75089392
53
Secondary prevention (medication) CVD vs no treatment74 570–970
5709707702.886490725
54
Episodic psychosocial care for depression primary care70 UMIC 914
9149149142.960946196
55
HPV (Human PapillomaVirus) vaccination @$240+/girl75–77 168–5168
168516826683.426185825
56
Use Xpert to diagnose TB MIC78 810–1316
810131610633.026533265
57
BCC (Behavior Change Communications) alone sex establishments73 LAC 1186
1186118611863.074084689
58
Primary prevention CVD abs risk >40% UMIC3 1373
1373137313733.137670537
59
Facility-based treatment of schizophrenia with drugs MIC6379 1427–1574
142715741500.53.176236
60
Telemedicine diabetic retinopathy screening 1-2 times/lifetime MIC80 1605
1605160516053.205475037
61
Treatment of depression in primary care with drugs MIC6370 1312–2048
1312204816803.225309282
62
Screen and treat breast cancer MIC57 1838
1838183818383.264345507
63
Primary prevention CVD with four drugs MIC7481 1070–3207
107032072138.53.330109255
64
Vector control for dengue82 2500–3000
2500300027503.439332694
65
Online sex education to prevent sexually transmitted infections83 1180–10256
11801025657183.757244151
66
Screen and treat breast cancer LIC84 3578
3578357835783.553640336
67
PMTCT Option A (with mass screening) versus no treatment85 LAC 3092–7924
3092792455083.740993932
68
PrEP-ARV for for noninfected partner serodiscordant couples86 Cost-saving to 6468
0646832343.810770011
69
Treat severe malaria with artesunate versus quinine78 Africa & Southeast Asia 5
5550.6989700043
70
Zinc added to oral rehydration therapy87 10–50
1050301.477121255
71
Community management severe-acute malnutrition97–99 25–40
254032.51.511883361
72
Maternal and neonatal care at home88 13–126
1312669.51.841984805
73
Micronutrient interventions (biofortification fortification supplementation)89–96 20–100
20100601.77815125
74
Management of obstructed labour100 77
7777771.886490725
75
Clean delivery kit and train TBAs88 82
8282821.913813852
76
Education programmes on nutrition/WASH101 95
9595951.977723605
77
Home management of fever with antimalarials versus referral45 96
9696961.982271233
78
Original EPI-6 (Expanded Program of Immunization with six vaccines) plus Hepatitis B10337–39 103
1031031032.012837225
79
Pneumococcus and rotavirus104–116 LIC 103
1031031032.012837225
80
Handwashing BCC (behavior change communications)102 90–225
90225157.52.197280558
81
Oral rehydration therapy87 153
1531531532.184691431
82
Household water treatment LIC120 190
902251902.278753601
83
Access to modern contraceptives119 150–300
1503002252.352182518
84
Quality improvement protocol newborns in hospital88 305
3053053052.484299839
85
Intrapartum care in Latin America and the Caribbean64 310
3103103102.491361694
86
Intrapartum care6566121 LICs* 200–500
205003502.544068044
87
Comprehensive nutrition package (all interventions Lancet 2013) 353
3533533532.547774705
88
*Mother's groups to improve maternal/neonatal health117118 150–1000
15010005752.759667845
89
HiB and rubella added to EPI 105123–128 LICs 368–768
3687685682.754348336
90
Region specific vaccines (Yellow fever Japanese encephalitis meningitis A)129–131 368–768
3687685682.754348336
91
Pneumococcus and rotavirus (market price lower-mid income countries)104105111113132–140 368–768
3687685682.754348336
92
Cholera and typhoid vaccination141142 2018
2018201820183.304921162
93
Pneumococcus and rotavirus (market price upper-mid IC)113114133135143– 146 2018
2018201820183.304921162
94
C-section all LMICs147 1600–2600
1600260021003.322219295
95
Rural water supply/sanitation LIC148 2200
2200220022003.342422681
96
Urban water supply/sanitation LIC148 2900
2900290029003.462397998
97
Microfinance/gender training for intimate partner violence149 2910
2910291029103.463892989
98
99
100