CoAST_2016_v1.xlsx
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DrugClassRoutePharmacodynamicsStrep pyogenesS. pneumoniaeStaph aureus (MSSA)Staph aureus (MRSA)Enterooccus faecalisEnterococcus faecium (VRE)ListeriaH. influenzaeMoraxella cattarhalisNeisseria meningitidisProteus spp.E. coliKlebsiellaPseudomonas aeruginosaEnterobacter cloacaeSerratiaB. fragilisAtypical respiratory pathogens"Spectrum Score"
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Penicillin GPenicillinIVBactericidal+++++--X++--++----+++XXXXXX--X12
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AmoxicillinPenicillinPOBactericidal+++++--X+++--+++++--+++++--XXXX--X18
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AmpicillinPenicillinIVBactericidal+++++--X+++--+++++--+++++--XXXX--X18
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NafcillinPenicillinIVBactericidal++++++++X------------XXXXXX--X8
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DicloxacillinPenicillinPOBactericidal++++++++X------------XXXXXX--X9
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Amoxicillin/clavulanatePenicillinPOBactericidal++++++++X+++--+++++++++++++++++++XX--+++X30
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Piperacillin/tazobactamPenicillinIVBactericidal++++++++X++--+++++++++++++++++++++++++++++X39
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Cefazolin CephalosporinIVBactericidal+++++++++XXXX--+--++++++XXXXX16
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CephalexinCephalosporinPOBactericidal++++++++XXXX------++++++XXXXX14
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Cefuroxime CephalosporinPO/IVBactericidal++++++XXXX+++++++++++++XXXXX20
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Cefotetan/CefoxitinCephalosporinIVBactericidal++++++XXXX+++++++++++++XXX+X20
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Ceftriaxone/CefotaximeCephalosporinIVBactericidal++++++++XXXX++++++++++++++++++--+++++--X31
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CeftazidimeCephalosporinIVBactericidal+++----XXXX+++++++++++++++++++++++++--X28
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Ceftazidime/avibactam
Cephalosporin
IVBactericidal+++----XXXX+++++++++++++++++++++++++++--X30
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Ceftolozane/tazobactam
Cephalosporin
IVBactericidal+++----XXXX+++++++++++++++++++++++++++--X29
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CeftarolineCephalosporinIVBactericidal+++++++++++----X++++++++++++++++++--+++++--X34
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CefepimeCephalosporinIVBactericidal+++++++++XXXX++++++++++++++++++++++++++--X35
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AztreonamMonobactamIVBactericidalXXXXXXX+++++++++++++++++++++++++XX25
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ErtapenemCarbapenemIVBactericidal+++++++++XXX++++++++++++++++++++X+++++++++X38
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Imi/Mero/DoripenemCarbapenemIVBactericidal+++++++++X+--+++++++++++++++++++++++++++++++X41
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CiprofloxacinFluoroquinolonePO/IVBactericidal++------------++++++++++++++++++++++++--+27
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LevofloxacinFluoroquinolonePO/IVBactericidal++++++++------++++++++++++++++++++++++--+++35
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MoxifloxacinFluoroquinolonePO/IVBactericidal+++++++++------+++++++++++++++++--+++++++++35
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ErythromycinMacrolidePO/IVBacteriostatic+++----XX------+XXXXXXX+++7
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ClarithromycinMacrolidePOBacteriostatic+++----XX--++++XXXXXXX+++10
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AzithromycinMacrolidePO/IVBacteriostatic+++----XX--++++++X----XXXX+++12
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DoxycyclineTetracyclinePO/IVBacteriostatic--++++++++--+++++------X------+++16
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TigecyclineTetracyclineIVBacteriostatic++++++++++++++++--++++++++--++++++X++++++++++++42
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Gentamicin/tobramycinAminoglycosideIVBactericidalsynsynsynsynsynsynsyn++--++++++++++++++++XX18
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TMP/SMXAntifolatePO/IVBactericidal----++++XX+++------+++++X++++XX13
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ClindamycinLincosamidePO/IVBacteriostatic+++++++XX--XXXXXXXXX+--8
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MetronidazoleNitroimidazolePO/IVBactericidalXXXXXXXXXXXXXXXX+++X3
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LinezolidOxazolidininonePO/IVBacteriostatic++++++++++++++++++--------XXXXXXX--18
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Quinupristin/dalfopristinStreptograminIVBacteriostatic++++++++++++X++--XXXXXXXXXXX14
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DaptomycinLipopeptideIVBactericidal+++++++++++++++++--XXXXXXXXXXX17
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VancomycinGlycopeptideIVBactericidal+++++++++++++++X--XXXXXXXXXXX15
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KEY
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+++=Drug of choice or >90% susceptibility; reliable empiric therapy in all but rare situations
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++=Alternative drug or >70% susceptibilty; usually reliable for empiric therapy but caution in severe infections
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+=Not generally reliable for empiric therapy except in low-risk situations
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---=lacks clinically useful activity or clinical experience; not reliable for empiric therapy; may have utility in rare situations
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X=intrinsically resistant
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syn=only useful for Gram-positive infections in combination with a cell-wall active agent
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