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VISUAL DISCRIMINATIONPAIRED ASSOCIATES LEARNINGEXTINCTION5-CHOICE SERIAL REACTION TIME TASKLOCATION DISCRIMINATIONSpatial repeated acquisition and performance (RAP) taskTRIAL-UNIQUE NON-MATCH TO LOCATIONVMCLDouble-cued conditional learningAUTOSHAPINGAUTOMATED SORIDEDNon-spatial NMTSContextual rule switching (CRS)Visual conditional response selectionX-CPT
Visual transverse patterning
Transitive inferenceVisual categorisation(Biological) Motion coherenceASATActivityVISUAL SEARCHDISCOUNTING
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YearFirst authorLead PIPMIDReferencePaper titleTypeSpeciesSexBackground
Nature of model or manipulation (e.g. Gene mutation, over-expression, KO, Tg, promoter, toxin, brain region, drug)
Neurotransmitter system
Key disease relevanceWeight phenotype
Observations
Other comments
Novel task?
Cambridge-style protocol/chambers?
Task orderPre-training
Mag and response latency
1 pair - acquisition
1 pair - Retention/performance
1 pair - overall reversal
1 pair - early reversal
1 pair - mid reversal1 pair - late reversalPerseveration indexFeedback analysis
Reversal probe (devaluation)
Bubbles probe8 pair4 pair3 pairStimuli used for discriminationPAL - acquisitionPAL - performance
DPAL (control) - performance
Instrumental Acquisition
Instrumental Extinction
Reinstatement
Baseline acquisition
AccuracyVigilanceOmissionsPerseveration - overallPerseveration - correct
Perseveration - incorrect
Perseveration - premature
PrematureRTMag lat
Additional manipulations and notable effects
Intermediate training
Probe - small
Probe - intermediate
Probe - largeReversalAcquisition
Performance
AcquisitionDelay - shortDelay - long
Separation - large
Separation - small
Interference (no ITI)AcquisitionReversal
Perseveration index
AcquisitionRetention/performanceOmission probe
Simultaneous extinction probe
Static 2DMoving stimuliFeatureConjunctiveDelayRewardDrug treatment
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Notes: Please email alexa.horner@cantab.net with suggested changed. This document was believed to be exhaustive (wrt published work) on 16.12.13
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Yellow highlighting indicates something that needs, or may need, to be changed.
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2013aAbela, A. R.Chudasama, Y.22615141Cereb Cortex. 2013 Jun;23(6):1396-409Inhibitory Control Deficits in Rats with Ventral Hippocampal LesionsOriginalRatMaleLong-EvansExcitotoxic NMDA lesion of the ventral hippocampus-----Impulsive and perseverative on 9-hole 5CSRTNoYesNaiveNot statedLonger mag lat if anything (seen in acquisition during non-correction trials only)No effect-No effectNo effectNo effect----Atypical - see paper-----------------------------------------------
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2013bAbela, A. R.Chudasama, Y.23190048Eur J Neurosci. 2013 Feb;37(4):640-7Dissociable contributions of the ventral hippocampus and orbitofrontal cortex to decision-making with a delayed or uncertain outcomeOriginalRatMaleLong-EvansExcitotoxic NMDA lesion of the ventral hippocampus-----YesYesDelay discounting, probability discountingn/aNo effect--------------------------------------------------------Impaired (intolerant of delay)No effect-
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Excitotoxic NMDA lesion of orbitofrontal cortex (OFC)-----YesYesDelay discounting, probability discountingn/aNo effect--------------------------------------------------------No effect Impaired (intolerant of uncertainty)-
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2013cAbela, A. R.Chudasama, Y.24062084Psychopharmacology (Berl). 2014 Feb;231(3):521-31.Noradrenergic α2A-receptor stimulation in the ventral hippocampus reduces impulsive decision-making.OriginalRatMaleLong-EvansBilateral intra-vHPC infusion of guanfacine (α2A-adrenergic receptor agonist)NoradrenergicADHD---NoYesDelay discounting onlyn/aNo effectIncreased delay tolerance (dose-dependent)
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Bilateral intra-vHPC infusion of SCH 23390 (dopamine D1 receptor antagonist)DopaminergicADHD---NoYesDelay discounting onlyn/aNo effectNo effect
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Bilateral intra-vHPC infusion of muscimol/baclofen cocktail (GABAA/B agonists), resulting in temporary deactivationGABAergicADHD---NoYesDelay discounting onlyn/aNo effectReduced delay tolerance
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1997Aggleton, J. P.Bussey, T. J.9227838Brain Res Bull. 1997;43(3):279-87.Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat.OriginalRatMalePigmented DAExcitotoxic NMDA lesion encompassing perirhinal, postrhinal and TE-Alzheimer---NoYesSOR, forced alternation, VDNot statedNo effect (VD)Mild impairment (NS)--------Cross/rectangle-----------------------------------------------
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2012Barkus, C.Holmes, A.21693126Neuropharmacology. 2012 Mar;62(3):1263-72Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?OriginalMouseBoth>75% C57BL/6JAMPA GluA1 subunit KO, globalGlutamatergicSchizophrenia---NoYesSeparate naive cohortsNot statedNo effectNo effect-No effectFacilitatedMildly facilitated (trend)Not stated---Assume marbles/fan---Facilitated (faster)Impaired------------------------------------------
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2011Bartko, S. J.Saksida, L. M.21903112Neuropharmacology. 2011 Dec;61(8):1366-78.Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method.OriginalMouseMaleC57BL/6M1 receptor KO, globalCholinergicAlzheimer---NoYes1: 5C. 2: VDR (easy), PAL, VDR (hard), VDR (morph)Not statedSee 5CNo effect (easy/hard/morph)-No effect (easy/hard/morph)--Not stated---Easy (marbles/fan) and hard (face/building) and hard morphedNo effect-----No effectNo effectFacilitated (details in "additional 5C manipulations")FacilitatedImpairedMildly impaired (trend; particularly same not different)Mildly impaired (trend)ImpairedImpairedNo effectNo effectHigh event rate 200 trial sessions: facilitated (persevered with completing trials)-----------------------------
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2011bBartko, S. J.Bussey, T. J.21086119Psychopharmacology (Berl). 2011 Mar;214(2):537-48.A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.OriginalMouseMaleC57BL/6Scopolamine (competitive, non-selective muscarinic receptor antagonist), systemic (i.p.)CholinergicSchizophrenia, Alzheimer---NoYesn/an/aIncreased-----------Impaired---------------------------------------------
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MouseMaleC57BL/6Dicyclomine (M1 receptor antagonist), systemic (i.p.)CholinergicSz, AD---NoYesn/an/aIncreased-----------Impaired---------------------------------------------
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MouseMaleC57BL/6Donepezil (selective acetylcholinesterase inhibitor), systemic (i.p.)CholinergicAlzheimer---NoYesn/an/aNo effect-----------Facilitated---------------------------------------------
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2012Botly, L. C. P.De Rosa, E.22095213Cereb Cortex. 2012 Oct;22(10):2441-53.Impaired visual search in rats reveals cholinergic contributions to feature binding in visuospatial attentionOriginalRatMaleLong-Evans192 IgG-saporin lesion bilateral NBM lesionCholinergicAlzheimer---YesNon/an/aSee visual search------------------------------------------------------No effectImpaired (longer to make correct response)-
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2013Braida, D.Sala, M.23291156Behav Brain Res. 2013 Apr 1;242:95-101.Mice discriminate between stationary and moving 2D shapes: application to the object recognition task to increase attention.OriginalMouseMaleSwissNone-----YesNo, iPadsSeparate naive cohortsn/an/aDiscrimination comparable to hand SORDiscrimination of movement types. Movement improved discriminability of shapes.
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Scopolamine (competitive, non-selective muscarinic receptor antagonist), systemic (i.p.)CholinergicAlzheimer---YesNo, iPadsSeparate naive cohortsn/an/aImpaired (formerly discriminable shapes not discriminated)-
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Mecamylamine, systemic (i.p.)CholinergicAlzheimer---YesNo, iPadsSeparate naive cohortsn/an/aImpaired (as above)-
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Nicotine, systemic (i.p.)CholinergicAlzheimer---YesNo, iPadsSeparate naive cohortsn/an/aImproved (formerly non-discriminable shapes became discriminable)-
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2013Brigman, J. L.Holmes, A.23831965Nat Neurosci. 2013 Aug;16(8):1101-10. GluN2B in corticostriatal circuits governs choice learning and choice shifting.OriginalMouseMaleC57BL/6JNone. Trained to one of the 5 stages (see comments), then c-Fos expression in 13 forebrain regions was quantified immunocytochemically----5 stage analysis: first/last acquisition session, first/middle/last reversal session. Comparison of these for WT mice. NoYesVDR onlyn/an/aLow DS (dlS, dmS) activation relative to late acquisition. Low PFC (OFC, prelimbic) activationHigh DS (dlS, dmS) activation relative to early acquisition. PFC activation remains low. High PFC activation relative to acquisition phases. Very low DS activation (inhibited?)PFC activation high but lower than early reversal (decreasing). DS activation higher than early reversal (increasing). Low PFC activation. High DS activation relative to all phasesAssume marbles/fan
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None. In vivo dorsal striatum neuronal recordings-----NoYesVDR onlyn/an/aDS neuronal population shows inhibition just after a correct choice is madeDS neurons show inhibition just after a correct choice is made, then excitation after reward is collectedAs in mid phase, but stronger inhibition/excitationAssume marbles/fan
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None. Ex vivo dorsal striatum slice recordings - LTD-----NoYesVDR onlyn/an/aDS LTD impaired (but seen after 3 stimulations)DS LTD impaired (but seen after 2 stimulations)LTD absent i.e. loss of plasticity (perseverating)LTD mildly impaired i.e. some recovery of plastivityLTD absent i.e. loss of plasticity (highly trained)Assume marbles/fan
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Excitotoxic bilateral NMDA lesion of dorsolateral striatum-----NoYesVD onlyn/aNo effectImpairedAssume marbles/fan
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Corticostriatal Grin2b gene deletion (affecting cortex, striatum, CA1; not thalamus or BLA). Grin2b(CxStNull) mutants
Glutamatergic----NoYesSeparate naive cohorts on VDR and extinctionNo effectNo effectImpairedImpairedAssume marbles/fanNo effectNo effect
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Striatal Grin2b gene deletion (affecting striatum only). Grin2b(StNull) mutantsGlutamatergic----NoYesVDR onlyNo effectNo effectImpairedImpairedAssume marbles/fan
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Cortical Grin2b gene deletion (affecting cortex, CA1). Grin2b(CxNull) mutantsGlutamatergic----NoYesVDR onlyNo effectNo effectNo effectImpaired (CTs not errors)
Impaired (CTs not errors)
No effectAssume marbles/fan
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Dorsolateral striatum GluN2B (NMDAR subunit) antagonism with Ro 25-6981 performed in separate cohorts at early/mid/late reversalGlutamatergic----NoYesVDR onlyn/aNo effectNo effect (so DS not required)Impaired (so DS GluN2Bs required)No effectAssume marbles/fan
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OFC GluN2B antagonism with Ro 25-6981 performed in separate cohorts at early/mid/late reversalGlutamatergic----NoYesVDR onlyn/aNo effect
Impaired (CTs not errors)
No effectAssume marbles/fan
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2010Brigman, J. L.Holmes, A.20032063Cereb Cortex. 2010 Aug;20(8):1955-63Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in miceOriginalMouseMaleC57BL/6J5-HTT null (KO and het)SerotonergicDepression, OCD--They note poor WT performance perhaps related to BGNoYesn/aNo effectNo effectHet and KO mildly facilitated (ns)-Het and KO facilitatedNo effectNo effectNo effect---Assume marbles/fan-----------------------------------------------
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MouseMaleC57BL/6JChronic fluoxetine, oral (drinking water)SerotonergicDepression, OCD---NoYesn/an/aNo effectNo effect-No effectFacilitatedNo effectNo effect---Assume marbles/fan-----------------------------------------------
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MouseBothC57BL/6JPet-1 null (KO and het)SerotonergicDepression, OCD---NoYesn/aNo effectNo effectHet mildly facilitated (ns)-No effectNo effectNo effectNo effect---Assume marbles/fan-----------------------------------------------
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MouseMaleC57BL/6JPara-chlorophenylalanine (PCPA; 5-HT synthesis inhibitor), systemic (i.p.)SerotonergicDepression, OCD---NoYesn/an/aNo effectn/a-No effectNot statedNot statedNo effect---Assume marbles/fan-----------------------------------------------
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MouseMaleC57BL/6JDSP-4 (noradrenaline depletion), systemic (i.p.)Serotonergic----NoYesn/an/aNo effectn/a-No effectNot statedNot statedNo effect---Assume marbles/fan-----------------------------------------------
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2009Brigman, J. L.Holmes, A.19255630Front Behav Neurosci. 2009;3:2.Ežffects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.OriginalMouseMaleC57BL/6JSubchronic PCP (NMDA R antagonist)GlutamatergicSchizophrenia---NoYesn/aNo effectNo effectNo effect-No effectNot statedNot statedNo effect---Assume marbles/fan-----------------------------------------------
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2008Brigman, J. L.Holmes, A.18230672Learn Mem. 2008 Jan 28;15(2):50-4.Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit.OriginalMouseBothC57BL/6JNR2A NMDA R subunit null (KO and het)GlutamatergicSchizophrenia---Yes?YesSeparate naive cohortsNo effectNo effectKO impaired-KO impairedNo effectKO impairedNo effect---Assume marbles/fan---No effectNo effect------------------------------------------
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2008bBrigman, J. L.Rothblat, L. A.18022704Behav Brain Res. 2008 Mar 5;187(2):405-10.Stimulus specific deficit on visual reversal learning after lesions of medial prefrontal cortex in the mouse.OriginalMouseMaleC57BL/6JExcitotoxic NMDA lesion of mPFC (ACC pre- and post-genu of CC, PL, some IL)-----NoYesn/aNot stated
No effect (luminance and pattern)
-No effect (luminance), impaired (pattern)No effect (luminance and pattern)-----Pair of line stimuli (varying "pattern"), pair of chequer-board stimuli (varying "luminance"); equidifficult-----------------------------------------------
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2006Brigman, J. L.Rothblat, L. A.16893304Behav Neurosci. 2006 Aug;120(4):984-8.Executive functions in the heterozygous reeler mouse model of schizophrenia.OriginalMouseMaleB6C3FHeterozygous reeler (+/rl) miceGABAergicSchizophrenia---NoYesn/aNot statedNot stated-----------------------------------------------Impaired (late) reversal only---------
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2005Brigman, J. L.Rothblat, L. A.15998206Behav Neurosci. 2005 Jun;119(3):839-42.Discrimination of multidimensional visual stimuli by mice: Intra- and extradimensional shifts.OriginalMouseMaleC57BL/6None-None---YesYesn/an/an/a-----------------------------------------------WTs only---------
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2013Brooks, D. I.
Wasserman, E. A.
23316977J Exp Psychol Anim Behav Process. 2013 Jan;39(1):85-92Categorization of photographic images by rats using shape-based image dimensions.OriginalRatMaleLong-EvansNone-----YesNon/an/an/aSuccessfully learned; generalised
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2013Bussey, T. J.Baxter, M. G. 23792049Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2141-8. Testing long-term memory in animal models of schizophrenia: Suggestions from CNTRICS.ReviewBothn/an/a
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2012Bussey, T. J.Saksida, L. M.21530550Neuropharmacology. 2012 Mar;62(3):1191-203.New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats.ReviewBothn/an/a
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2008Bussey, T. J.Saksida, L. M.18612068Learn Mem. 2008 Jul 8;15(7):516-23.The touchscreen cognitive testing method for rodents: How to get the best out of your rat.ReviewRatn/an/a
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2001Bussey, T. J.Rothblat, L. A.11508736Behav Neurosci. 2001 Aug;115(4):957-60.Discrimination of computer-graphic stimuli by mice: a method for the behavioral characterization of transgenic and gene-knockout models.OriginalMouseMaleC57BL/6None-None---YesYesVD then 3pcTested in WTn/aWT onlyWT only-----WT onlyVarious including marbles/fan-------------------------------------------
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2001bBussey, T. J.Aggleton, J. P.11508717Behav Neurosci. 2001 Aug;115(4):776-85.Perirhinal cortex and place-object conditional learning in the rat.OriginalRatMalePigmented DAExcitotoxic NMDA lesion of perirhinal cortex-Alzheimer---YesYesn/an/aNot stated------No effect
No effect (acquisition and retention)
-------------------------------------------------
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2000Bussey, T. J.Aggleton, J. P.10840144Behav Brain Res. 2000 Jun 15;111(1-2):187-202.Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat.OriginalRatMalePigmented DAExcitotoxic NMDA lesion of perirhinal/postrhinal cortex-Alzheimer---NoYesHand tests, auto, VD, VMCLNot statedNo effect (auto)No effect--------Cross/rectangle----------------------------No effect---Facilitated--------------
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RatMalePigmented DARadiofrequency fornix lesion-Alzheimer---NoYesHand tests, auto, VD, VMCLNot statedFaster general approach latencies (auto)No effect--------Cross/rectangle----------------------------No effect---No effect--------------
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1998Bussey, T. J.Muir, J. L.9454867J Neurosci. 1998 Feb 15;18(4):1622-31.Fornix lesions can facilitate acquisition of the transverse patterning task: a challenge for "configural" theories of hippocampal functionOriginalRatMalePigmented DARadiofrequency fornix lesion-Alzheimer---YesYesn/aNot statedFacilitated RT, normal mag---------------------------------------------------Facilitated-----
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1997bBussey, T. J.Robbins, T. W.9383513Behav Neurosci. 1997 Oct;111(5):908-19.Dissociable ežffects of cingulate and medial frontal cortex lesions on stimulus-reward learning using a novel Pavlovian autoshaping procedure for the rat: Implications for the neurobiology of emotion.OriginalRatMaleLister hoodedQuinolinic acid anterior cingulate cortex lesion (post-genu ACC only)-----YesYesn/aNot statedNo general effect------------------------------------------Impaired (high CS- approaches, no latency difference)-No effect------------
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RatMaleLister hoodedQuinolinic acid posterior cingulate cortex lesion-----YesYesn/aNot statedHigh general approach latency (trend)------------------------------------------No effect-No effect------------
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RatMaleLister hoodedQuinolinic acid medial frontal cortex lesion (pre-genu ACC and some anterior PL and IL)-----YesYesn/aNot statedHigh general approach latency------------------------------------------No effect-No effect------------
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RatMaleLister hoodedPost-training intra-Nac infusion of sulpiride (D2 R antagonist), with delayed and vehicle controlsDopaminergic----NoYesn/aNot statedNot stated------------------------------------------No effectNo effectNo effect------------
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1997Bussey, T. J.Robbins, T. W.9383514Behav Neurosci. 1997 Oct;111(5):920-36.Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat.OriginalRatMaleLister hoodedQuinolinic acid anterior cingulate cortex lesion (post-genu ACC only)-----YesYesCohort 1: VMCL, 8PrC, Cohort 2: VDR (hard), Cohort 3: VDR (easy)Not statedIncreased mag lat (VMCL, easy VDR)No effect-No effectNo effectNo effect-Impaired--Easy: unknown. Hard: blue/green.----------------------------No effect------------------
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RatMaleLister hoodedQuinolinic acid posterior cingulate cortex lesion-----YesAs aboveNot statedIncreased RT (easy VDR rev), decreased mag lat (easy VDR)No effect-No effectNo effectNo effect-Facilitated--Easy: unknown. Hard: blue/green.----------------------------Impaired (70-85%)------------------
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RatMaleLister hoodedQuinolinic acid medial frontal cortex lesion (pre-genu ACC and some anterior PL and IL)-----YesAs aboveNot statedDecreased RT (VMCL)No effect-Easy: no effect. Hard: impairedNo effectImpaired (39-85%)-No effect--Easy: unknown. Hard: blue/green.----------------------------No effect------------------
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1994Bussey, T.J.Robbins, T. W.-Neuroscience Research Communications. 1994; 15(2):103-10A Novel Automated Touchscreen Procedure for Assessing Learning in the Rat Using Computer Graphic StimuliOriginalRatMalen/aNone-----YesYesn/an/a-------2 rats only-------------------------------2 rats only---------3 rats only--------
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2003Cardinal, R. N.Everitt, B. J.12802885Behav Neurosci. 2003 Jun;117(3):566-87.Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats.OriginalRatMaleLister hoodedQuinolinic acid anterior cingulate cortex lesion (pre- and post- genu of CC)-----NoYesOther Pav conditioning tasks firstNot statedNo general effect------------------------------------------Impaired (approaches)--Impaired (mild, trend)-----------
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2002Cardinal, R. N.Everitt, B. J.12148923Behav Neurosci. 2002 Aug;116(4):553-67.Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.OriginalRatMaleLister hoodedQuinolinic acid nucleus accumbens core (AcbC) lesion-----NoYesn/an/aNo general effect-------------------------------------------
Impaired (reduced CS+ approaches)
-------------
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RatMaleLister hoodedQuinolinic acid anterior cingulate cortex (ACC) lesion (pre- and post- genu of CC)-----Yesn/aGeneral slower approaches, but normal locomotor test-------------------------------------------
Impaired (reduced CS+ approaches)
-Impaired relative to controls, but discrimination evident-----------
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RatMaleLister hoodedQuinolinic acid central nucleus of the amygdala (CeA) lesion-----Yesn/aNo effect-------------------------------------------No effect-No effect-----------
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2009Chen, W.Pemberton, D. J.19654507Behav Pharmacol. 2009 Oct;20(7):653-6.Effect of donepezil on reversal learning in a touch screen-based operant task.OriginalRatMaleLister hoodedSystemic donepezil (0.5mg/kg/day)CholinergicAlzheimer--They falsely call it "probabilistic"YesYesn/an/aNot statedNo effect-Facilitated-
Facilitated (approx. >50%)
----Triangles and diamond-----------------------------------------------
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2005Christakou, A.Everitt, B. J.15733096Eur J Neurosci. 2005 Feb;21(3):782-92.Prolonged neglect following unilateral disruption of a prefrontal cortical-dorsal striatal system.OriginalRatMaleLister hoodedCombined unilateral (ipsi) quinolinic acid lesion of mPFC and mCPu (medial caudate-putamen)-Parkinson's---NoYes9-hole box 5CSRT, autoshapingn/aNo general effect------------------------------------------Mildly impaired (high CS- approaches on ipsi side)--------------
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2001Christakou, A.Everitt, B. J.11508720Behav Neurosci. 2001 Aug;115(4):812-25Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function.OriginalRatMaleLister hoodedQuinolinic acid contralateral disconnection lesion of mPFC and mCPu-Parkinson's---NoYesNaïve cohortsNot statedNo effect------------------------------------------No effect--------------
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2003Chudasama, Y.Robbins, T. W.14507977J Neurosci. 2003 Sep 24;23(25):8771-80.Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex.OriginalRatMaleLister hoodedQuinolinic acid orbitofrontal cortex (OFC) lesion (mainly OFC, some PL and IL)-----NoYesNaïve cohortsNot statedAutoshaping acquisition: longer RT and maglat. VD acquisition: longer RTNo effect-ImpairedImpairedNo effect----Rectangle and cross--------------------------------Impaired (reduced CS+ approaches), similar pattern in first omission probeMildly impaired (first block only). See "omission probe" for second probeFewer overall approaches (p = 0.051)------------
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RatMaleLister hoodedQuinolinic acid infralimbic cortex (ILC) lesion-----NoYesVD acquisition: faster RT and maglat. Reversal similar but NS.No effect-ImpairedNo effectMildly impaired (trend)----Rectangle and cross-------No effect-
Impaired (p = 0.053)
-----
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2001Chudasama, Y.Muir, J. L.11595039Eur J Neurosci. 2001 Sep;14(6):1009-20.Ežffects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning.OriginalRatMaleLister hoodedNMDA lesion of anterior thalamic nuclei-----NoYes1: VDR, VMCL. 2: VMCL+RNot statedNo effectNo effect-No effectNo effectNo effectImpaired---Rectangle and cross----------------------------No effectNo effectNo effect----------------
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RatMaleLister hoodedNMDA lesion of mediodorsal thalamic nuclei-----NoYesNo effectNo effect-ImpairedNo effectImpairedImpaired---Rectangle and cross----------------------------No effectImpaired (overall)No effect----------------
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RatMaleLister hoodedNMDA lesion of prelimbic cortex (mainly PL, some OFC and IL)-----NoYesFirst rev: slower RTNo effect-No effectNo effectNo effectImpaired---Rectangle and cross----------------------------No effectNo effectNo effect----------------
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2011Clark, R. E.Squire, L. R.21482362Neuron. 2011 Apr 14;70(1):132-40.Intact performance on feature-ambiguous discriminations in rats with lesions of the perirhinal cortex.OriginalRatFemaleLong-EvansIbotenate acid lesion of bilateral perirhinal cortex-Alzheimer--Not exactly a touchscreen... images displayed, detects licksNoNoVD training, then performance with interpolated morph probesn/aNot statedNo effectNo effect (incl. morph)-------Photographic b/w paint brush and torch, with incremental morphs
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2009Clelland, C. D.Bussey, T. J.19590004Science. 2009 Jul 10;325(5937):210-3.A functional role for adult hippocampal neurogenesis in spatial pattern separation.OriginalMouseFemaleC57BL/6X-irradiation focal ablation of hippocampal neurogenesis-Alzheimer, schizophrenia---NoYesPAL, LDNot statedNot stated----------No effect-----------------No effectImpaired-No effect-------------------------
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2012Coba, M. P.Grant, S. G. N.23035106J Neurosci. 2012 Oct 3;32(40):13987-13999.TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive FunctionOriginalMouseMaleC57BL/6 x 129S5 (ratio unclear)Global TNiK KOGlutamatergicSchizophreia---NoYesLD, PALNot statedNo effect----------Impaired-----------------Not statedImpaired-No effectNot stated------------------------
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2004Cook, R. G.Gowda, R.15190705Behav Res Methods Instrum Comput. 2004 Feb;36(1):101-6.Touchscreen-enhanced visual learning in rats.OriginalRatNot statedLong-EvansNone-----NoNOn/aWT onlyWT onlyWT only--------Vertical and horizontal stripes-----------------------------------------------
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2010Creer, D.J.Bussey, T. J.20133882Proc Natl Acad Sci U S A. 2010 February 2; 107(5): 2367–2372.Running enhances spatial pattern separation in mice.OriginalMouseMaleC57BL/6Voluntary wheel running in adult mice (increased neurogenesis)-----NoYesn/aNo effectNot stated----------------------------No effectFacilitated-No effect
Mild facilitation (small only)
------------------------
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MouseMaleC57BL/7Voluntary wheel running in aged mice (no effect on neurogenesis)-Alzheimer---NoYesn/aNo effectNot stated----------------------------Mild facilitation---No effect------------------------
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2005Dalley, J. W.Robbins, T. W.15833811Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6189-94.Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbensOriginalRatMaleLister hoodedPost-training intra-Nac infusion of SCH 23390 (D1 R antagonist), with delayed and vehicle controlsDopaminergic----NoYesn/aNot statedNot stated------------------------------------------ImpairedImpairedImpaired------------
77
RatMaleLister hoodedPost-training intra-Nac infusion of D-amphetamine, with delayed and vehicle controlsDopaminergic----NoYesn/aNot statedNot stated------------------------------------------No effectNo effectNo effect------------
78
RatMaleLister hoodedPost-training intra-Nac infusion of AP-5 (NMDA R antagonist), with delayed and vehicle controlsGlutamatergic----NoYesn/aNot statedNot stated------------------------------------------ImpairedNo effectImpaired------------
79
2002Dalley, J. W.Robbins, T. W.12073171Psychopharmacology (Berl). 2002 Jun;161(4):425-33.Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration.OriginalRatMaleLister hooded6-hydroxydopamine lesion of nucleus accumbens + pre-training vehicle-Parkinson's---NoYesn/aNot statedNo effect------------------------------------------No effect (discriminated approach), although decreased approach freq-Impaired------------
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RatMaleLister hooded6-hydroxydopamine lesion of nucleus accumbens + pre-training 30ug/kg apomorphineDopaminergicParkinson's---NoYesn/aNot statedLonger approach latencies------------------------------------------Impaired (discriminated approach), but decreased approach frequency--------------
81
RatMaleLister hooded6-hydroxydopamine lesion of nucleus accumbens + pre-training 100ug/kg apomorphineDopaminergicParkinson's---NoYesn/aNot statedLonger approach latencies------------------------------------------Impaired (discriminated approach), no effect on approach freq-No effect------------
82
RatMaleLister hoodedSham lesion + pre-training 30ug/kg apomorphineDopaminergic----NoYesn/aNot statedLonger approach latencies------------------------------------------Impaired (discriminated approach), but decreased approach frequency--------------
83
RatMaleLister hoodedSham lesion + pre-training 100ug/kg apomorphineDopaminergic----NoYesn/aNot statedLonger approach latencies------------------------------------------Transient facilitation (discriminated approach), decreased appr freq-No effect------------
84
2013Depoy, L.Holmes, A.23959891Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14783-8.Chronic alcohol produces neuroadaptations to prime dorsal striatal learning.OriginalMouseMaleC57BL/6JChronic intermittent ethanol exposure. Given prior to phase of interest (acquisition/reversal/autoshaping/extinction/reinforcer devaluation)CannabinoidSubstance abuse---NoYesNaïve cohortsn/aNo effectFacilitated (fewer CTs)No effectFacilitated (errors and CTs)No effect of devaluation or CIE (i.e. habitual)Assume marbles/fann/aFacilitatedNo effectFacilitated
85
CIE before reversal; in vivo dorsal striatum neuronal recordingsCannabinoidSubstance abuse---NoYesNaïve cohortsn/an/aNo effectDelayed activation of DS neuronal population when correct response madeReduced inhibition of DS neuronal population 3-6s after correct responseAssume marbles/fan
86
2013Dickson, P. E.Mittleman, G.23747611Behav Brain Res. 2013 Sep 1;252:126-35Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndromeOriginalMouseMaleFVB.129P2-Pde6b+ Tyrc-chFmr1 KO mice (specifically, Fmr1(tm1Cgr) hemizygous targeted mutation)-Fragile X--Series of 4 reversalsYesSimilarn/aNot statedNo effect. Fmr1s made more erroneous attempts to collect rewards after incorrect choices in rev 1No effectNo effect (except 2nd of 4 reversals when low salience stim correct)No effect (2nd rev low salience group only; <=40%)Impaired (2nd rev low salience group only; 41-80%)Black and white + (low salience) and x (high salence)
87
2012Foley, A. G.Regan, C. M.22683514Neuropharmacology. 2012 Sep;63(4):750-60Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder.OriginalRatMaleWistarIn utero VPA model of Austism Spectrum Disorders + veh-ASDNoKinked tail-YesYesn/aNot statedNot statedImpairment
88
In utero VPA model of Austism Spectrum Disorders + pan-specific HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) i.p.-ASDNoKinked tail-YesYesn/aNot statedNot statedMilder impairment (ameliorated but not rescued)
89
2009Galizio, M.Pitts, R. C.19772870Pharmacol Biochem Behav. 2009 Dec;94(2):305-11Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats.OriginalRatMaleHoltzman Sprague–DawleySystemic methylenedioxymethamphetamine (MDMA, 0.3–10 mg/kg, i.p.)-Substance abuse - psychomotor stimulant--10mg/kg often caused complete suppression of responding, so excluded from analysesNoNon/an/aSlow RT during acquisition (3 mg/kg i.e. max dose)Impaired accuracy (3 mg/kg); no effect at lower dosesNo effect
90
Systemic methamphetamine (MA, 0.1–3 mg/kg, i.p.)-Substance abuse - psychomotor stimulant--3mg/kg often caused complete suppression of responding, so excluded from analysesNoNon/an/aNo significant effectImpaired accuracy (particularly at 1mg/kg i.e. max dose)Impaired accuracy (particularly at 1mg/kg i.e. max dose)
91
Systemic methylphenidate (MPD,1–17 mg/kg, i.p.)-Substance abuse - psychomotor stimulant--17mg/kg often caused complete suppression of responding, so excluded from analysesNoNon/an/aSlow RT during performance and acquisition (10mg/kg i.e. max dose)Impaired accuracy (particularly at 10mg/kg i.e. max dose)Impaired accuracy (particularly at 10mg/kg i.e. max dose)
92
2011Graybeal, C.Holmes, A.22057192Nat Neurosci. 2011 Nov 6;14(12):1507-9.Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF.OriginalMouseMaleC57BL/6JStress (3x forced swim)-----NoYesNaïve cohortsNot statedSlow RT (late rev)No effect-FacilitatedNo effectFacilitated (≥50%)----Assume marbles/fan---No effect-------------------------------------------
93
MouseMaleC57BL/6JStress (3x forced swim, plus additional swims throughout reversal training)-----NoYesn/an/aNo effect--No effectNo effectFacilitated (≥50%)----Assume marbles/fan-----------------------------------------------
94
MouseMaleC57BL/6JStress (1x forced swim)-----NoYesn/an/aNo effect--No effectNo effectNo effect----Assume marbles/fan-----------------------------------------------
95
MouseMaleC57BL/6JStress (3x forced swim) + vmPFC infusion of BDNF-----NoYesn/an/aNo effect--No effectNo effectNo effect----Assume marbles/fan-----------------------------------------------
96
MouseMaleC57BL/6JNMDA lesion of vmPFC (mainly prelimbic, with infralimbic in some animals)-----NoYesn/an/aNo effect--FacilitatedNo effectFacilitated (≥50%)----Assume marbles/fan-----------------------------------------------
97
MouseMaleC57BL/6JNMDA lesion of OFC-----NoYesn/an/aNo effect--Impaired------Assume marbles/fan-----------------------------------------------
98
MouseMaleC57BL/6JNMDA lesion of dorsolateral striatum-----NoYesn/an/aNo effect--Impaired------Assume marbles/fan-----------------------------------------------
99
MouseMaleC57BL/6JNone or stress (3x forced swim). Trained to chance reversal performance, then reward was devalued (or not)-----YesYesn/an/aNo effectNo effect of stress or devaluation (i.e. habitual)---Assume marbles/fan
100
2008Hefner, K.Holmes, A.18685032J Neurosci. 2008 Aug 6;28(32):8074-85.Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain.OriginalMouseMale129S1/SvImJ, C57BL/6JNone - background comparison-----NoYesn/aNot statedNot stated129S1 faster than BL/6JNo effect
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