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Vendredi 12 décembre 2025 @13h00
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Jean-Francois Poulin
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McGill University, The Neuro
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emailj-francois.poulin@mcgill.ca
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Titre:Mapping molecular and functional diversity within the mouse dopaminergic system
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Résumé:The degeneration of dopamine neurons leads to the onset of the cardinal locomotor symptoms of Parkinson’s disease (PD). For reasons we currently ignore, some dopamine neurons are severely affected in PD, whereas others are relatively spared. Using single-nuclear RNA sequencing and spatial transcriptomic approaches, we established the molecular signature and location of distinct dopamine neuron subtypes in the mouse midbrain. Using intersectional genetic strategies to selectively inhibit or ablate dopamine neuron subpopulations, we identified distinct contributions to locomotion. Altogether, our work provides evidence of the molecular and functional diversity of the mouse dopaminergic system and has important implications for our understanding of PD as well as other neuropsychiatric disorders.
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Vendredi 12 décembre 2025
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13h00 - 14h00TalkF-1455
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14h30 - 15h00Christian EthierF6561-11
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15h00 - 15h30Vincent Breton Provencher F5577
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15h30 - 16h00Christophe
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16h00 - 16h30Marie-Eve PaquetF-7522
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Bolduc C, Oram C, Donovan S, Bach H, Talbot G, Liu M, Marier R, Sharpe M, Spencer D, Martin SA, Awatramani R, Poulin JF. (2025). Calbindin stratifies midbrain dopa-minergic neurons governing distinct aspects of locomotion. BioRxiv 2025.07.07.663227.
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Gaertner Z*, Oram C*, Schneeweis A, Schonfeld E, Bolduc C, Chen C, Dombeck D, Parisiadou L, Poulin JF*, Awatramani R* (2025) Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease. eLife, 13:RP101035.
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Poulin JF, Caronia G, Hofer C, Cui Q, Helm B, Ramakrishnan C, Chan CS, Dombeck DA, Deisseroth K, Awatramani RB (2018). Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches. Nat Neurosci, 21:1260–71.
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