ABCDEFGHIJKLMNOPQRSTUVWX
1
Insecticide resistance adjustment including PBO netsUgandaTogoNigeriaChadDemocratic Republic of the CongoGuineaCameroonMadagascarMalawiSouth SudanZambia
2
Synergist bioassay results (IR Mapper data), 2015-2019
3
Number of synergist bioassays conducted (with matching bioassays with pyrethroid insecticide only)43420383242238906
4
Average mosquito mortality in bioassays with pyrethroid insecticide + PBO95%93%93%55%96%90%69%99%83%96%100%
5
Average mosquito mortality in same bioassays with pyrethroid insecticide only51%11%69%43%56%60%25%82%20%53%31%
6
Initial proportion of resistance that remains when using PBO (tested areas)9%8%24%80%9%26%40%3%21%9%0%
7
8
External validity adjustments for country representativeness
9
Number of test sites with confirmed pyrethroid insecticide resistance (IR Mapper data, 2015-2019)75192432512426912380058
10
Number of test sites without confirmed pyrethroid insecticide resistance (IR Mapper data, 2015-2019)10146030871689012
11
Proportion of test sites with confirmed pyrethroid insecticide resistance (IR Mapper data, 2015-2019)99%100%62%100%81%76%93%12%90%90%83%
12
Proportion of sites detected to have relevant resistance mechanism (WHO Malaria Threat Map data, 2010-2017)83%79%79%71%100%79%90%100%100%92%100%
13
Estimated proportion of country where PBO nets are more effective than standard LLINs82%79%49%71%81%61%84%12%90%81%83%
14
15
Estimated adjustment incorporating PBO net adjustment
16
Reduction in effectiveness due to insecticide resistance without PBO nets45%61%22%62%40%27%49%8%45%37%31%
17
Reduction in effectiveness due to insecticide resistance in areas where PBO nets are effective4%5%5%50%4%7%20%0%10%3%0%
18
Reduction in effectiveness due to insecticide resistance in areas covered by PBO nets, untargeted11%17%14%53%11%15%25%7%13%10%5%
19
Proportion of PBO nets purchased100%50%100%30%90%30%100%20%80%100%80%
20
Assumed scenario: perfect targeting of PBO nets11%33%14%59%11%21%25%7%17%10%6%
21
22
Final reduction in effectiveness due to insecticide resistance including PBO nets (entire country)11%33%14%59%11%21%25%7%17%10%6%
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100