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8/12/18All Life Science Standards
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HS-LS1-1: FROM MOLECULES TO ORGANISMS: STRUCTURES AND PROCESSES
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Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells.
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Clarification Statement
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Emphasis is on the conceptual understanding that DNA sequences determine the amino acid sequence and thus protein structure. Students can produce scientific writing, or presentations, and/or physical models that communicate constructed explanations.
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Science and Engineering PracticeDisciplinary Core Idea
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Constructing explanations and designing solutions:
Constructing explanations (science) and designing solutions (engineering) in 9–12 builds on K–8 experiences and progresses to explanations and designs that are supported by multiple and independent student-generated sources of evidence consistent with scientific ideas, principles, and theories.

• Construct and revise an explanation based on valid and reliable evidence obtained from a variety of sources (including students’ own investigations, models, theories, simulations, peer review) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future.
STRUCTURE AND FUNCTION
Systems of specialized cells within organisms help them perform the essential functions of life. (HS.LS1A.a)

All cells contain genetic information in the form of DNA molecules. Genes are regions in the DNA that contain the instructions that code for the formation of proteins which carry out the essential functions of life. (HS.LS1A.c)
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Caddo Science Symbaloo
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Crosscutting Concepts
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STRUCTURE AND FUNCTION
Investigating or designing new systems or structures requires a detailed examination of the properties of different materials, the structures of different components, and connections of components to reveal its function and/ or solve a problem.
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HS-LS1-2: FROM MOLECULES TO ORGANISMS: STRUCTURES AND PROCESSES
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Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.
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Clarification Statement
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Emphasis is on functions at the organism system level such as nutrient uptake, water delivery, or organism movement in response to neural stimuli. An example of an interacting system could be an artery depending on the proper function of elastic tissue and smooth muscle to regulate and deliver the proper amount of blood within the circulatory system.
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Science and Engineering PracticeDisciplinary Core Idea
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Developing and using models:
Modeling in 9-12 builds on K-8 experiences and progresses to using synthesizing and developing models to predict and show relationships among variables between systems and their components in the natural and designed world(s).

• Develop, revise, and/ or use a model based on evidence to illustrate and/ or predict the relationships between systems or between components of a system.
STRUCTURE AND FUNCTION
Multicellular organisms have a hierarchical structural organization, in which any one system is made up of numerous parts and is itself a component of the next level. (HS.LS1A.b)
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Caddo Science Symbaloo
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Crosscutting Concepts
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SYSTEMS AND SYSTEM MODELS
Models (e.g., physical, mathematical, computer models) can be used to simulate systems and interactions— including energy, matter, and information flows—within and between systems at different scales.
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HS-LS1-3: FROM MOLECULES TO ORGANISMS: STRUCTURES AND PROCESSES
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Plan and conduct an investigation to provide evidence that feedback mechanisms maintain homeostasis in living organisms.
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Clarification Statement
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Examples of investigations could include heart rate responses to exercise, stomatal responses to moisture and temperature, root development in response to water levels, or cell response to hypertonic and hypotonic environments.
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Science and Engineering PracticeDisciplinary Core Idea
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Planning and carrying out investigations:
Planning and carrying out investigations to answer questions or test solutions to problems in 9-12 builds on K-8 experiences and progresses to include investigations that provide evidence for and test conceptual, mathematical, physical, and empirical models.

• Plan and conduct an investigation individually and collaboratively to produce data to serve as the basis for evidence, and in the design: decide on types, how much, and accuracy of data needed to produce reliable measurements and consider limitations on the precision of the data (e.g., number of trials, cost, risk, time), and refine the design accordingly.
STRUCTURE AND FUNCTION
Feedback mechanisms maintain a living system’s internal conditions within certain limits and mediate behaviors, allowing the organism to remain alive and functional even as external conditions change within some range. Feedback mechanisms can promote (through positive feedback) or inhibit (negative feedback) activities within an organism to maintain homeostasis. (HS.LS1A.d)
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Caddo Science Symbaloo
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Crosscutting Concepts
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STABILITY AND CHANGE
Feedback (negative or positive) can stabilize or destabilize a system.
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HS-LS1-4: FROM MOLECULES TO ORGANISMS: STRUCTURES AND PROCESSES
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Use a model to illustrate the role of the cell cycle and differentiation in producing and maintaining complex organisms.
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Clarification Statement
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Emphasis is on conceptual understanding that mitosis passes on genetically identical materials via replication, not on the details of each phase in mitosis.
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Science and Engineering PracticeDisciplinary Core Idea
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Developing and using models:
Modeling in 9-12 builds on K-8 experiences and progresses to using synthesizing and developing models to predict and show relationships among variables between systems and their components in the natural and designed world(s).

• Develop, revise, and/ or use a model based on evidence to illustrate and/ or predict the relationships between systems or between components of a system.
GROWTH AND DEVELOPMENT OF ORGANISMS
In multicellular organisms the cell cycle is necessary for growth, maintenance and repair of multicellular organisms. Disruptions in the cell cycles of mitosis and meiosis can lead to disease such as cancer. (HS.LS1B.a)

The organism begins as a single cell (fertilized egg) that divides successively to produce many cells, with each parent cell passing identical genetic material (two variants of each chromosome pair) to both daughter cells. (HS.LS1B.b)

Cellular division and differentiation (stem cell) produce and maintain a complex organism, composed of systems of tissues and organs that work together to meet the needs of the whole organism. (HS.LS1B.c)
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