Nonredundant Annotated Kidney Stone Matrix Proteome Database May 2016.xlsx
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ABCDEFGHIJKLMNOPQRSTUVWXYZ
1
HUMAN KIDNEY STONE MATRIX PROTEOME DATABASE
Bold Red - highly expressed in kidney
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BOLD entries in columns 1-3 are common to one or more additional studies; # detected only in our CaOx/Brushite comparison study (unpublished)Red - moderately expressed in kidney
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Gray shading for proteins detected only in other studies [1-14]
Black - low expression level in kidney
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Bold Green - Not expressed in kidney
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Gene SymbolProtein NameFound in other studiesIsoelectric Pointnegatively charged residues (Asp + Glu)positively charged residues (Arg + Lys)Neg/Pos RatioAliphatic indexGRAVYMolecular ClassBiological ProcessCellular componentFunction
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GBE11,4-alpha-glucan-branching enzyme#6.1081671.2176.87-0.385Enzyme: GlycosyltransferaseMetabolism; Energy pathwaysCytoplasm; Extracellular vesicular exosomeRequired for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.
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HSPE110 kDa heat shock protein, mitochondrial#4.47961.50101.28-0.117Heat shock proteinProtein metabolismMitochondrion; NucleolusEukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
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EFTUD2116 kDa U5 small nuclear ribonucleoprotein component4.841561001.5690.39-0.245UnclassifiedProtein metabolismNucleus; Nucleolus; Cytoplasm; ChromosomeComponent of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP
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PHPT114 kDa phosphohistidine phosphatase5.6618141.2973.23-0.484Enzyme: PhosphataseUnknownCytoplasmExhibits phosphohistidine phosphatase activity.
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YWHAB14-3-3 protein beta/alpha[14]4.7644301.4775.71-0.740Adapter moleculeSignal transductionCytoplasm; MitochondrionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Negative regulator of osteogenesis.
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YWHAE14-3-3 protein epsilon4.6351321.5985.76-0.540Adapter moleculeCell communication; Signal transductionCytoplasm; Nucleus; Golgi apparatus; Nucleolus; MitochondrionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.
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YWHAH14-3-3 protein eta4.7645321.4182.49-0.629Adapter moleculeCell communication; Signal transductionCytoplasm; NucleusAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Negatively regulates the kinase activity of PDPK1.
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YWHAG14-3-3 protein gamma4.8045301.5080.93-0.691Adapter moleculeCell communication; Signal transductionCytoplasm; Endoplasmic reticulum; Golgi apparatus; NucleusAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.
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SFN14-3-3 protein sigma4.6848301.6077.98-0.599Adapter moleculeCell communication; Signal transductionCytoplasmAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
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YWHAQ14-3-3 protein theta4.6844301.4783.71-0.512Adapter moleculeCell communication; Signal transductionCytoplasm; NucleusAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Negatively regulates the kinase activity of PDPK1.
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YWHAZ14-3-3 protein zeta/delta[14]4.4832181.7883.15-0.497Adapter moleculeRegulation of cell cycleCytoplasm; Cytosol; Plasma membraneAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
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HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)]5.5628231.2299.77-0.009Enzyme: DehydrogenaseMetabolism; Energy pathwaysCytoplasmProstaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4.
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PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2#6.121871721.0975.13-0.604Enzyme: PhospholipaseMetabolism; Energy pathways; Signal transductionCytoplasm; Perinuclear regionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
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DECR12,4-dienoyl-CoA reductase, mitochondrial#8.7928320.8887.54-0.042Enzyme: ReductaseMetabolism; Energy pathwaysMitochondrion; Endoplasmic reticulum;PeroxisomeAuxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
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OAS12'-5'-oligoadenylate synthase 1#8.5147520.9077.78-0.492Enzyme: LigaseImmune responseCytoplasm; NucleusInterferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation.
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OAS32'-5'-oligoadenylate synthase 3#8.731051210.8785.89-0.249Enzyme: LigaseImmune responseCytoplasm; Endoplasmic reticulum;Extracellular; NucleusInterferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation.
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PSMC626S protease regulatory subunit 10B7.0960601.0093.98-0.437Ubiquitin proteasome systemProtein metabolismCytoplasmThe 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
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PSMC126S protease regulatory subunit 45.8774671.1088.79-0.548Ubiquitin proteasome systemProtein metabolismNucleus; CytoplasmThe 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
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PSMC326S protease regulatory subunit 6A4.9466511.2991.66-0.396Ubiquitin proteasome systemProtein metabolismNucleusThe 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
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PSMC526S protease regulatory subunit 87.2760601.0099.14-0.327Ubiquitin proteasome systemProtein metabolismNucleus; CytoplasmThe 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
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PSMD126S proteasome non-ATPase regulatory subunit 15.241331011.3291.41-0.229Ubiquitin proteasome systemProtein metabolism; Proteolysis and peptidolysisNucleus; CytoplasmActs as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
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PSMD1126S proteasome non-ATPase regulatory subunit 116.0960561.07105.30-0.187Ubiquitin proteasome systemProtein metabolism; Proteolysis & peptidolysisNucleus; CytoplasmComponent of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly.
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PSMD1226S proteasome non-ATPase regulatory subunit 127.6868690.9997.69-0.389Ubiquitin proteasome systemProtein metabolismCytoplasmActs as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
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OGDH2-oxoglutarate dehydrogenase, mitochondrial, splice variant or isoform#6.1522191.1688.86-0.177Enzyme: DehydrogenaseMetabolism; Energy pathwaysMitochondrionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
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ITIH435 kDa inter-alpha-trypsin inhibitor heavy chain H4[1-2]6.51101971.0484.49-0.315Protease inhibitorProtein metabolismExtracellularType II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
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MRPL1239S ribosomal protein L12, mitochondrial[1, 14]5.3322191.16118.630.008Ribosomal subunitRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolismMitochondrion; NucleolusPositive regulation of transcription
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MRPL2839S ribosomal protein L28, mitochondrial#5.2235301.1790.25-0.591Structural proteinProtein metabolism; RNA metabolismMitochondrionMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.
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HSD17B103-hydroxyacyl-CoA dehydrogenase type-2#7.8721220.95101.350.227Enzyme: DehydrogenaseMetabolism; Energy pathwaysMitochondrion; Endoplasmic reticulum; Plasma membraneFunctions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids.
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BDH23-hydroxybutyrate dehydrogenase type 27.5627280.9693.96-0.022Enzyme: OxidoreductaseMetabolism; Energy pathwaysUnknownDehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport.
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HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial, splice variant or isoform#6.3047441.0790.93-0.214Enzyme: HydrolaseMetabolism; Energy pathwaysMitochondrionHydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
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ACAA23-ketoacyl-CoA thiolase, mitochondrial#8.3239420.9391.91-0.009Enzyme: AcyltransferaseMetabolism; Energy pathwaysMitochondrionAbolishes BNIP3-mediated apoptosis and mitochondrial damage.
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ACAA13-ketoacyl-CoA thiolase, peroxisomal#8.6838430.8891.230.010Enzyme: AcyltransferaseMetabolism; Energy pathwaysPeroxisome; Cytoplasm; MitochondrionAn enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. 
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MPST3-mercaptopyruvate sulfurtransferase6.1439341.1575.54-0.433Enzyme: SulphotransferaseMetabolism; Energy pathwaysMitochondrionTransfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant.
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RPS1040S ribosomal protein S10[1]9.9219310.6172.62-0.662Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.
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RPS1140S ribosomal protein S11#10.329270.3373.47-0.753Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.
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RPS15A40S ribosomal protein S15a#9.1810140.71104.410.015Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.
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RPS1840S ribosomal protein S18#10.9916360.4492.91-0.727Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.
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RPS240S ribosomal protein S210.8715370.4175.28-0.352Ribosomal subunitProtein metabolismRibosome; Nucleolus; Mitochondrion; CytoplasmComponent of the 40S ribosomal subunit.
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RPS2340S ribosomal protein S2310.2311270.4175.67-0.516Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPS340S ribosomal protein S39.1315180.8385.57-0.324Ribosomal subunitProtein metabolismCytoplasm; Nucleus; RibosomeComponent of the 40S ribosomal subunit.
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RPS3A40S ribosomal protein S3a9.4629400.7378.06-0.554Ribosomal subunitProtein metabolismCytoplasm; Nucleus; Nucleolus; Cytosol; RibosomeMay play a role during erythropoiesis through regulation of transcription factor DDIT3
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RPS4X40S ribosomal protein S4, X isoform10.1625490.5190.42-0.338Ribosomal subunitProtein metabolismRibosome; Nucleolus; CytosolComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPS540S ribosomal protein S58.6617190.8993.28-0.358Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPS640S ribosomal protein S611.1321610.3478.26-0.976Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPS740S ribosomal protein S710.0923380.6194.90-0.459Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPS840S ribosomal protein S810.3220540.3772.56-1.034Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPS940S ribosomal protein S9#11.0616350.46105.18-0.525Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 40S ribosomal subunit.; poly(A) RNA binding
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RPSA40S ribosomal protein SA4.7940261.5479.08-0.317Cell surface receptor, Ribosomal subunitCell communication; Signal transduction; Cell adhesionCytoplasm; Ribosome; Nucleolus; CytosolRequired for the assembly and/or stability of the 40S ribosomal subunit. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways.
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ALDH9A14-trimethylaminobutyraldehyde dehydrogenase5.6956511.1082.88-0.048Enzyme: DehydrogenaseMetabolism; Energy pathwaysCytoplasmConverts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
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ALAS15-aminolevulinate synthase, nonspecific, mitochondrial[1]8.1664670.9677.96-0.326Enzyme: SynthaseAmino acid and derivative metabolismMitochondrial matrix; CytoplasmMitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin)
biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the
enzyme that is specific for erythroid tissue.
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PRKAB25'-AMP-activated protein kinase subunit beta-2[3]5.9935291.2176.29-0.494Regulatory/other subunitCell communication; Signal transductionCytoplasmNon-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.
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HSPD160 kDa heat shock protein, mitochondrial5.2480791.01100.71-0.081Heat shock proteinProtein metabolism; Protein folding; Apoptosis; Regulation of immune response; Signal transductionMitochondrion; Cytoplasm; Plasma membrane; Mitochondrial matrix; Endoplasmic reticulum; Peroxisomal matrix; Secretory granule; Extracellular; Golgi apparatus; Nucleolus; CytosolImplicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
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RPLP060S acidic ribosomal protein P05.7036321.1395.140.040Ribosomal subunitProtein metabolismNucleus; Ribosome; Nucleolus; Cytoplasm; Cytosol; MitochondrionComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPLP160S acidic ribosomal protein P14.211872.5788.320.094Ribosomal subunitProtein metabolismRibosome; Cytoplasm; Mitochondrion; NucleusPlays an important role in the elongation step of protein synthesis.
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RPLP260S acidic ribosomal protein P24.3821121.7585.91-0.237Ribosomal subunitProtein metabolismCytoplasm; NucleolusPlays an important role in the elongation step of protein synthesis.
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RPL1060S ribosomal protein L10#10.5312390.3170.17-0.521Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL1160S ribosomal protein L11#9.6422330.6782.09-0.547Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL1460S ribosomal protein L1410.2112250.4867.66-0.544Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL1560S ribosomal protein L1511.6211500.2267.89-0.930Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL1860S ribosomal protein L1811.5911390.2887.87-0.546Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL18A60S ribosomal protein L18a#10.6710320.3158.39-0.842Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
67
RPL2260S ribosomal protein L2210.16590.5679.06-0.377Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
68
RPL23A60S ribosomal protein L23a10.4914430.3397.06-0.401Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL2460S ribosomal protein L24#10.7910380.2663.27-0.763Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
70
RPL2960S ribosomal protein L29[1]11.667470.1560.82-1.108Ribosomal subunitProtein metabolismPlasma membrane; Nucleus; Cytoplasm; Nucleolus; MitochondrionThe protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin.
71
RPL360S ribosomal protein L310.1939860.4574.13-0.653Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL3060S ribosomal protein L30#9.659190.4790.78-0.295Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL3260S ribosomal protein L3210.6012350.3481.57-0.680Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL460S ribosomal protein L4#11.0322850.2683.90-0.650Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL560S ribosomal protein L59.7335590.5966.93-0.752Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
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RPL660S ribosomal protein L6#11.652130.15108.25-0.210Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
77
RPL760S ribosomal protein L7#10.6715460.3390.05-0.493Ribosomal subunitProtein metabolismCytoplasm; Nucleus; Ribosome; Nucleolus;Cytosol; MitochondrionComponent of the 60S ribosomal subunit.; poly(A) RNA binding
78
RPL7A60S ribosomal protein L7a10.6121620.3491.28-0.556Ribosomal subunitProtein metabolismRibosome; NucleolusComponent of the 60S ribosomal subunit.; poly(A) RNA binding
79
RPL860S ribosomal protein L8[1]11.0417540.3176.95-0.537Ribosomal subunitProtein metabolismNucleolus; MitochondrionComponent of the 60S ribosomal subunit.; poly(A) RNA binding
80
RPL960S ribosomal protein L9#9.9620330.6199.38-0.354Ribosomal subunitProtein metabolismRibosome; Nucleolus; MitochondrionComponent of the 60S ribosomal subunit.; poly(A) RNA binding
81
PGD6-phosphogluconate dehydrogenase, decarboxylating6.8856551.0286.06-0.155Enzyme: DehydrogenaseMetabolism; Energy pathwaysCytoplasmCatalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
82
PGLS6-phosphogluconolactonase[2]5.7127221.23104.510.152Enzyme: HydrolaseMetabolism; Energy pathwaysCytoplasm; Extracellular vesicular exosome Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
83
HSPA578 kDa glucose-regulated protein[14]5.01111871.2883.21-0.547ChaperoneProtein metabolismEndoplasmic reticulum; Plasma membrane; Cytoplasm; Nucleolus; Endoplasmic reticulum lumen; Mitochondrion; Cell surfaceFacilitates the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10
84
ABI1Abl interactor 16.6149471.0469.47-0.627Adapter moleculeRegulation of cell growth; Signal transductionCytosolInvolved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac.Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
85
ASPMAbnormal spindle-like microcephaly-associated protein[1]10.452356840.3489.29-0.482UnclassifiedUnknownNucleus; MicrotubuleProbable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis.
86
ACAT1Acetyl-CoA acetyltransferase, mitochondrial#8.1637390.9596.070.097Enzyme: AcyltransferaseMetabolism; Energy pathwaysMitochondrion; CytoplasmPlays a major role in ketone body metabolism.
87
ACACAAcetyl-CoA carboxylase 1#5.952922531.1589.81-0.246Enzyme: CarboxylaseMetabolism; Energy pathwaysCytoplasm; NucleusCatalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
88
ASAH1Acid ceramidase[1, 3]5.6313111.1890.99-0.099Enzyme: HydrolaseMetabolism; Energy pathwaysLysosomeHydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
89
ANP32AAcidic leucine-rich nuclear phosphoprotein 32 family member A[3, 4]4.4740221.8294.69-0.711MHC complex proteinImmune responseCytoplasm; Nucleus; Plasma membraneImplicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.
90
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B[1, 4]3.9394273.4875.70-1.164ChaperoneNegative regulation of cell differentiationNucleus; Nucleolus; CytoplasmMultifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity By similarity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome
91
ANP32EAcidic leucine-rich nuclear phosphoprotein 32 family member E3.76102224.6474.22-1.176ChaperoneHistone exchangeNucleus; Nucleolus; Cytoplasm; cytoplasmic membrane-bounded vesicleHistone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions.
92
ACO2Aconitate hydratase, mitochondrial#6.9792901.0285.93-0.346Enzyme: HydrataseMetabolism; Energy pathwaysMitochondrionCatalyzes the isomerization of citrate to isocitrate via cis-aconitate.
93
ACPPACPP protein[2]9.2429360.8190.38-0.327Enzyme: Acid phosphataseMetabolism; Energy pathwaysExtracellular; Cytoplasm; Lysosome; NucleusA non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
94
ACTA1Actin, alpha[3, 4]5.2350371.3582.21-0.245Structural proteinCell growth and/or maintenanceCytoplasm; Kinetochore; ExtracellularActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
95
ACTC1Actin, alpha cardiac muscle 1#5.2350371.3583.25-0.241Cytoskeletal proteinCell growth and/or maintenanceCytoplasm; NucleusActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
96
ACTA2Actin, aortic smooth muscle#5.2450371.3582.48-0.246Cytoskeletal proteinCell growth and/or maintenanceCytoplasm; NucleusActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
97
ACTBActin, cytoplasmic 1[1, 4-6, 11, 14]5.2949371.3282.17-0.205Cytoskeletal proteinCell growth and/or maintenanceCytoplasm; Golgi apparatus; Plasma membrane; Nucleolus; Cytosol; Extracellular; Cytoskeleton; MitochondrionActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
98
ACTR2Actin-related protein 26.2953501.0696.14-0.185Cytoskeletal proteinCell motility; Cell growth and/or maintenanceCytoplasm; Actin cytoskeletonFunctions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.
99
ARPC1BActin-related protein 2/3 complex subunit 1B#8.8813170.7675.00-0.521Cytoskeletal associated proteinCell growth and/or maintenancePlasma membrane; Nucleolus; CytoplasmFunctions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
100
ARPC2Actin-related protein 2/3 complex subunit 2#6.8443421.0279.93-0.439Cytoskeletal associated proteinCell growth and/or maintenance; Cytoskeleton organization and biogenesisActin cytoskeleton; NucleolusFunctions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
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