Tau phosphorylation sites

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S	T	U	V	W	X	Y	Z	AA	AB	AC	AD	AE	AF	AG	AH	AI	AJ	AK	AL	AM	AN	AO	AP	AQ	AR
1	Tau phosphorylation sites					Diane Hanger - Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, UK
2	*Please refer to notes below*					Protein kinase
3	Residue number	Alzheimer PHF-tau	Control brain tau	Foetal rat tau	PSP-tau	c-Abl (Tyr kinase)	5' adenosine monophosphate-activated protein kinase (AMPK)	Brain-specific kinase 1/2 (BRSK)	Calcium-calmodulin kinase II	Cyclin-dependent kinase-5 (cdk5)	Casein kinase 1 (CK1)	Casein kinase 2 (CK2)	Cyclic AMP-dependent protein kinase (PKA)	Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)	Fyn (Tyr kinase)	Glycogen synthase kinase-3 (GSK-3)	JNK	LRRK2	Met (Tyr kinase)	Microtubule affinity-regulating kinase (MARK)	MSK1	p35/41	p42/p44 mitogen-activated protein kinases (ERKs1/2)	p38 mitogen-activated kinase (p38MAPK)	p70S6 kinase	Phosphorylase kinase	PKB/AKT	Protein kinase C (PKC)	Protein kinase N (PKN)	Prostate-derived sterile 20-like kinase 1 alpha/beta (PSK1/TAOK2)	Prostate-derived sterile 20-like kinase 2 (PSK2/TAOK1)	Rho kinase	90 kDa Ribosomal S6 kinase (RSK1/2)	Stress-activated protein kinase (SAPK) 1gamma	SAPK2a	SAPK2b	SAPK3	SAPK4	SGK1	SRPK2	Syk (Tyr kinase)	Tau-tubulin kinase 1/2 (TTBK1/2)	Alzheimer PHF-tau	Residue number

4	T17										*																			*	*													T17
5	Y18	A													*																										*		A	Y18
6	Y29																																											Y29
7	T30																	*												*	*											*		T30
8	T39											*																																T39
9	S46	A	*		*						*					*							*	*											*	*	*						A	S46
10	T50										*					*							*																					T50
11	T52											*																																T52
12	S56											*																																S56
13	S61																														*													S61
14	T63																													*														T63
15	S64																																											S64
16	S68	*																																									*	S68
17	T69	*														*							*	*																			*	T69
18	T71	*					*																																				*	T71
19	T76																													*	*													T76
20	T95										*																																	T95
21	T101										*																																	T101
22	T102										*																																	T102
23	T111																																											T111
24	S113	*									*																																*	S113
25	T123	A																												*													A	T123
26	S129																																											S129
27	S131			*					*		*																																	S131
28	T135								*									*																										T135
29	S137																	*																										S137
30	T149	A			A						*					*		*													*												A	T149
31	T153	A								*						*		*					*											*	*	*	*	*					A	T153
32	T169						*				*							*												*	*													T169
33	T175	*														*	*	*					*	*							*			*	*	*	*						*	T175
34	T181	*	*	*	*					*						*	*	*					*	*										*	*	*	*	*					*	T181
35	S184	*									*					*														*	*				*	*	*						*	S184
36	S185	*																						*						*	*												*	S185
37	S191	*																												*	*											*	*	S191
38	S195						*			*			*			*														*	*													S195
39	Y197	*																	*																								*	Y197
40	S198	*	*								*		*			*														*												*	*	S198
41	S199	*	*	*						*		*	*			*							*								*											*	*	S199
42	S202	*	*		*					*			*	*		*	*						*	*										*	*	*	*	*				*	*	S202
43	T205	*	*		A					*			*			*	*	*					*	*						*	*			*	*	*	*	*					*	T205
44	S208	*					*				*																															*	*	S208
45	S210	*		*							*		*			*		*																								*	*	S210
46	T212	*	*		A				*	*	*		*	*		*	*	*					*	*	*					*				*	*	*	*	*					*	T212
47	S214	*		*	A		*		*	*	*		*			*					*				*		*	*	*	*	*		*						*	*		*	*	S214
48	T217	*	*	*	*								*			*	*	*					*	*										*	*	*	*	*					*	T217
49	T220												*			*														*														T220
50	T231	*	*	*	*		*			*			*			*	*	*					*	*						*	*			*			*	*					*	T231
51	S235	*	*	*	*		*			*			*			*	*						*	*		*								*	*	*	*	*					*	S235
52	S237	*									*					*		*								*				*	*												*	S237
53	S238	*		S239 in rat							*																				*												*	S238
54	S241						*				*					*														*	*													S241
55	T245						*						*			*		*						*						*	*	*			*	*	*	*						T245
56	S258	*					*				*		*			*		*										*	*	*	*												*	S258
57	S262	*			A		*	*	*		*		*			*		*		*	*	*			*	*		*		*	*	*											*	S262
58	T263	*									*							*												*	*												*	T263
59	S285								*		*					*										*				*	*											*		S285
60	S289	*					*				*					*														*	*											*	*	S289
61	S293						*						*							*		*						*																S293
62	S305	*					*				*		*			*				*				*		*		*		*	*											*	*	S305
63	Y310																																											Y310
64	S316																																											S316
65	T319																														*													T319
66	S320												*							*				*					*															S320
67	S324	*					*						*			*		*		*		*						*	*	*	*											*	*	S324
68	S341										*																																	S341
69	S352										*		*			*										*		*	*		*													S352
70	S356	*		*			*		*		*		*			*	*	*		*			*	*		*				*	*			*	*	*	*	*				*	*	S356
71	T361										*							*												*	*													T361
72	T373						*				*					*		*												*	*													T373
73	T377																	*										*		*	*	*												T377
74	T386						*				*	*						*												*	*													T386
75	Y394	*				*												*																									*	Y394
76	S396	*	*	*	*					*	*	*				*	*						*	*										*	*	*	*	*					*	S396
77	S400	*	*	*	*		*					*				*														*	*												*	S400
78	T403	*		*	*		*											*												*	*												*	T403
79	S404	*	*	*	*					*	*	*		*		*							*	*																			*	S404
80	S409	*			A				*				*			*						*		*						*	*	*					*	*					*	S409
81	S412	*	*								*	*	*																		*												*	S412
82	S413	*	*		A						*	*	*			*														*	*												*	S413
83	T414	*	*								*	*																		*	*												*	T414
84	S416	A *	*	*					*		*	*	*																	*	*												A *	S416
85	S422	*		*	A				*				*				*						*	*						*	*											*	*	S422
86	T427	*																												*	*												*	T427
87	S433	*									*																			*	*												*	S433
88	S435	*									*		*					*												*	*												*	S435
89
90	NOTES						To cite this page, please use: https://bit.ly/2JyZTbS
91	Numbering refers to 2N4R human tau isoform						This page is updated occasionally, please send any comments or amendments by clicking on the link below:
92							Diane Hanger, Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience
93	"A" indicates sites identified using phospho-specific tau antibodies (see comments)						This page can be viewed or printed by exporting to MS Excel: File_Export_.xls
94
95	"*" indicates sites identified by direct means
96
97	Residues indicated in yellow are those for which no kinase has been identified						Updates
98							Date (YMD)	Notes		References
99	Hover over top corner of cells to see notes						20200714	TBK1 sites added		https://www.biorxiv.org/content/10.1101/2020.06.17.157552v1	Abreha et al, 2020
100							20200820	PHF-tau sites added		https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaa223/5893817	Drummond et al 2020