Dad diagnostics
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DiagnosticsCJDHashimoto's encephalopathyDementia with Lewy bodies (DLB)Hyperparathyroidism (hypercalcemia)Progressive supranuclear palsy (PSP) paraneoplastic syndromeDad
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14-3-3highhigh/normalhigh/normalnormalhigh
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total tauhighnormal/mildly highhighnormal
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MRIdiagnosticnormalnormalnormal
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EEGdiagnostic or slowslowslowslow
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dementiarapidrapidcan be rapidyesrapid?
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trembling (parkinsonism)yesyesyesyesyes
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muscle jerks (myoclonus)yesyesyesyes, when provoked
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hallucinationsyesyesyesnono
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thyroid microsomal antibodiesnoyesnoyes
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trouble swallowing (aphagia)yesnoyesyes?
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trouble speaking (aphasia)yesyesyesyes
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uncoordination (ataxia)yesyesyesyesyes
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memory loss/confusionyesyesyesyes
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previous post-op hallucinationnonoyesyes
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fluctuating cognitionnopossibleyesyesyesyes
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impaired attention spanyesyesyesyesyesyes
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muscle fatigueyesyesyesyesyes
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sleepinesspossibleyesyesyesyes
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blood pressurepossible changeshighhigh
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serum calciumnormalnormalnormalhighnormalmildly high
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ionized calciumnormalnormalnormalvariesnormal
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PTHnormalnormalnormalhighnormalhigh
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responds to steroidsnoyesnononono
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weakness on one sidenoyesyesyes?
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insomniayesnoyesno
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thrashing sleep/REM disordernonoyesno
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tiny writing (micrographia)yespossibleyes
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epileptic seizuresrareyesnono
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drooling (sialorrhea)yesyes
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low speech volumeyesyes
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arrhythmiasnononoyesnoyes, but note cardiac history
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FREQUENCY (per million)1 / 1,000,00021 / 1,000,000underdiagnosed and fairly common1,000 / 1,000,00060 / 1,000,000
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Note that none of the diagnostics is ever 100% certain, either positive or negative.Steroids failed to help, so not this.Symptoms persisted when serum calcium brought to normal with drugs.
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