Supplementary_table1.xlsx

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O
1	Group	Protein family	Cluster 0	Cluster 1	Cluster 2	Cluster 3	Cluster 4	Cluster 5	Cluster 6	Cluster 7	Cluster 8	Cluster 9	Cluster 10	Cluster 11	Total

2	Group 1	a) Affinity propagation clustering of the Lysozyme CGCh dataset (SC=0.30)
3
4		Lysozyme C	17	33	2	0	Not applicable (only 4 clusters)								52
5		Lysozyme G	0	1	0	16									17
6		Lysozyme Ch	0	0	51	3									54
7		Total	17	34	53	19									123
8		b) Affinity propagation clustering of the Xylanase dataset (SC=0.17)
9
10		GH10	60	138	109	41	0	1	0	3	0	Not applicable (only 9 clusters)			352
11		GH11	0	0	3	0	80	59	92	45	68				347
12		Total	60	138	112	41	80	60	92	48	68				699
13		c) Affinity propagation clustering of the Chitinase dataset (SC=0.15)
14
15		GH18	85	53	15	77	45	77	40	69	0	1	Not applicable (only 10 clusters)		462
16		GH19	6	10	0	9	2	0	0	0	94	73			194
17		Total	91	63	15	86	47	77	40	69	94	74			656
18	Group 2	d) Affinity propagation clustering of the Lysozyme CaLA dataset (SC=0.29)
19
20		Lysozyme C	8	11	33	0	Not applicable (only 4 clusters)								52
21		α-Lactalbumin	1	0	0	21									22
22		Total	9	11	33	21									74
23		e) Affinity propagation clustering of the Protease dataset (SC=0.23)
24
25		Trypsin	14	5	20	28	Not applicable (only 4 clusters)								67
26		Chymotrypsin	0	0	10	6									16
27		Total	14	5	30	34									83
28		f) Affinity propagation clustering of the Ferredoxin dataset (SC=0.20)
29
30		FDX1	9	0	Not applicable (only 2 clusters)										9
31		FDX2	2	5											7
32		Total	11	5											16
33	Group 3	g) Affinity propagation clustering of the β-Glucosidase dataset (SC=0.19)
34
35		GH1	61	58	53	73	17	81	0	1	3	1	Not applicable (only 10 clusters)		348
36		GH3	0	0	0	0	0	0	61	28	35	80			204
37		Total	61	58	53	73	17	81	61	29	38	81			552
38		h) Affinity propagation clustering of the Lysozyme dataset (SC=0.19)
39
40		GH22	19	36	26	42	12	0	Not applicable (only 6 clusters)						135
41		GH24	0	0	0	1	0	30							31
42		GH23	0	0	0	0	2	45							47
43		Total	19	36	26	43	14	75							213
44		i) Affinity propagation clustering of the β-Galactosidase dataset (SC=0.25)
45
46		GH2	22	25	3	1	0	0	0	7	9	25	25	Not applicable (only 11 clusters)	117
47		GH42	2	8	0	0	0	0	0	17	17	16	23		83
48		GH35	0	5	97	78	20	57	31	1	0	2	4		295
49		Total	24	38	100	79	20	57	31	25	26	43	52		495
50	Group 4	j) Affinity propagation clustering of the GH2 dataset (SC=0.20)
51
52		β-Galactosidase	8	15	43	23	11	17	Not applicable (only 6 clusters)						117
53		β-Glucuronidase	0	9	52	6	1	17							85
54		Total	8	24	95	29	12	34							202
55		k) Affinity propagation clustering of the GH3 dataset (SC=0.22)
56
57		β-Glucosidase	20	25	61	73	11	10	2	2	Not applicable (only 8 clusters)				204
58		1,4-β-Xylosidase	8	7	2	0	4	22	40	16					99
59		Total	28	32	63	73	15	32	42	18					303
60		l) Affinity propagation clustering of the GH5 dataset (SC=0.10)
61
62		Cellulase	49	55	68	54	37	11	68	Not applicable (only 7 clusters)					342
63		Endo-β-Mannanase	0	7	35	29	14	3	39						127
64		Total	49	62	103	83	51	14	107						469
65	Group 5	m) Affinity propagation clustering of the SNARE dataset (SC=0.06)
66
67		non-SNARE	28	28	5	Not applicable (only 3 clusters)									61
68		SNARE	0	20	37										57
69		Total	28	48	42										118
70		n) Affinity propagation clustering of the GPCR1 (SC=0.05)
71		n) Affinity propagation clustering of the GPCR1 (SC=0.05)
72		GPCR	497	206	194	208	332	93	23	57	0	55	0	32	1697
73		non-GPCR (TM)	138	54	202	41	71	105	257	445	62	99	176	257	1907
74		Total	635	260	396	249	403	198	280	502	62	154	176	289	3604
75		o) Affinity propagation clustering of the GPCR2 dataset (SC=0.11)
76
77		GPCR	242	668	746	15	26	Not applicable (only 5 clusters)							1697
78		non-GPCR (no TM)	41	77	8	811	924								1861
79		Total	283	745	754	826	950								3558
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