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COZYME webinars: Complete List of Talks (2023-2026)
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COMPLETE LIST of TALKS
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DateWebinar #
WG1. Computational optimization of global enzyme properties
WG2. Computational optimization of catalytic properties
WG3. Experimental evaluation and characterization
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02/03/20231Bettina Nestl (AT)Identification and optimization of novel enzymes by 3D point cloud CatalophoresTMJeppe Kari (DK)The Sabatier principle as a tool for in-silico driven discovery and engineering of industrial enzymes: Relating sequence and kinetics Dirk Tischler (DE)Flavin-dependent oxidases: from lignin to valuable products
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04/05/20232Mehmet Özbil (TR)Exploiting enzyme mutations for biotechnological purposesJordi Villà-Freixa (ES)Primer on Empirical Valence Bond CalculationsBuse Çaloğlu / Barış Binay (TR)Production of Lachancea thermotolerans L-Asparaginase in Pichia pastoris
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06/07/20233Vladimir Sladek (SK)Quantifying Residue Roles in Biomolecular Complexes by Combining Dynamics, Quantum Chemistry and Residue Interaction NetworksMaria Bzówka / Artur Góra (PL)Water molecules as a key for enzymes interior understanding and reshapingCarlos Acevedo-Rocha (DK)Engineering cofactor specificity in formate dehydrogenase
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14/09/20234Gustav Oberdorfer (AT)Ideal is pretty, but irregular more interesting - functionalization of parametrically designed helix bundles by deviating from ideal geometries.Guillem Casadevall / Silvia Osuna (ES)Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient EsteraseMax Haeussler / Juergen Pleiss (DE)EnzymeML: Seamless data flow from raw data to kinetic parameters
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23/11/20235Mehdi Davari (DE)Design of Enzymes Towards Organic Solvent ResistanceMarc van der Kamp (UK)Simulation-guided redesign of terpene synthase product outcomeBekir Engin Eser (DK)Engineering of Fatty Acid Modifying Enzymes for Substrate Specificity and Regioselectivity
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01/02/20246Giulia Morra (IT)Energy based mapping as a computational prediction tool for protein stability, folding and allosteryNatalia Kulik (CZ)In silico modulation of beta-N-acetylhexosaminidase substrate affinities by mutationsMarco Fraaije (NL)Structure-based redesign of flavoproteins
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21/03/2024Demo- webinar #1Milos Musil (CZ)Computational Design of Stable Proteins: FireProtASR, FireProt, and FireProtDB
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06/06/20247Alfonso Gautieri (IT)Rational design of a fructosyl peptide oxidase enzyme to widen its active site access tunnelTomica Hrenar (HR)Quantum-chemical multiple ligands simultaneous docking to cholinesterases: a case study in inhibitor developmentZvjezdana Findrik Blazevic (HR)Application of kinetic models in the optimization of complex enzymatic systems
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25/07/20248Lukas Pluska (DE)Exazyme: AI-Powered Protein EngineeringUwe Bornscheuer (DE)Enzyme engineering using directed evolution, rational design and machine learning for biocatalytic applicationsCancelled
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19/09/20249Martin Havlasek (CZ)AggreProt: Analysis (and Design) of Protein Aggregation Prone RegionsLynn Kamerlin (USA)Conformational Dynamics and Enzyme EvolutionLígia Martins (PT)New Engineered Laccases for Lignin Valorization
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21/11/2024Demo- webinar #2Innophore (AT) - Katharina Rauchenwald-KöchlSearch & optimization of novel proteins by 3D point-cloud CatalophoresTM // CavitOmix Pro: the protein and drug discovery platformInnophore (AT) - Lena PariggerCavitOmiX Copilot: Precision off-target screening across the human cavitome // CavitOmiX Copilot: Hands-on demo
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23/01/202510Francesca Paradisi (CH)Enzymes in Hybrid Catalytic SystemsLaura Masgrau Fontanet (ES)Structural, energetic and dynamical features behind the improved stability of computationally designed DyP peroxidasesEvangelos Topakas (GR)Discovery of novel enzymes for the bioconversion of plastic waste
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20/03/202511Jinbei Li (DK)A Method for Massive, High-Diversity, and Full-Length Enzyme Sequence-Fitness Data Collection for Machine Learning-Aided Enzyme EngineeringJoan Planas-Iglesias (CZ)LoopGrafter: a Web Tool for Transplanting Dynamical Protein Loops for Protein EngineeringMarlène Martinho (FR)Protein dynamics studied by Site-Directed Spin Labeling and Electron Paramagnetic Spectroscopy (SDLS-EPR) : example of P450 reductase
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22/05/202512Per-Olof Syren (SE)Conformational selection in enzymatic depolymerization of plastics Ioana Ilie (NL)Computational design of Bax-inhibiting peptidesFernando López (ES)Region-directed immobilization of enzymes through structure-guided surface engineering
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24/07/2025Demo- webinar #3Max Haeussler (DE)Streamlined handling and modeling of plate reader data using the EnzymeML frameworkMax Haeussler (DE)MTPHandler: managing plate reader data in Jupyter NotebooksMax Haeussler (DE)Chromatopy: managing chromatographic data in Jupyter Notebooks
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25/09/202513Peter Fojan (DK)New scaffolds for de novo designed enzymesDaniel Platero-Rochart (AT)SmarTSzyme: computational tool to manipulate enzyme activityAndrás Telek (HU)Accessible biocatalyst development by Rapid In vitro Sem-rational Engineering (RISE) of enzymes
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20/11/202514Jonathan Funk (DK)ProteusAI: An Open-Source and User-Friendly Platform for Machine Learning-Guided Protein EngineeringOscar Romero Ormazábal (ES)Biocatalyst-driven CO2 conversion: Upcycling industrial feedstocks into high-value productsAbdulkadir Yayci (DE)Structure prediction-guided design of P450 assemblies
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22/01/202615Rebecca Buller (CH)Improving Enzyme Fitness with Machine LearningRomas Kazlauskas (USA)Why engineering faster enzymes is hardTom Desmet (BE)Evolving a glycosyl transferase into a phosphorylase through ancestral sequence reconstruction
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19/03/2026Demo- webiar #4Hein Wijma (NL)
Enzyme stabilization with FRESCOKerlen Korbeld (NL)Enriching stabilizing mutations using BoostMutHein Wijma / Kerlen Korbeld(NL)Setting up FRESCO and BoostMut
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21/05/202616Jan Brezovsky (PL)Exposing unseen passages for ligand transport through proteins with high-throughput simulationsJulia Reisenbauer (AUT)A unified computational and experimental pipeline for discovering unknown enzyme activitiesGemma Kinsella (IRL)Novel alcohol dehydrogenase activation by the choline component of deep eutectic solvents
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23/07/202617Brian Wiley / Carmen Domene (UK)Deep Geometric Learning for Enhanced Probing of Gas-Dependent EnzymesAgata Raczynska (PL)Unraveling the Molecular Basis of Polyester-Polyurethane Hydrolysis: Structural Insights and Engineering of TfCut2Cancelled
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24/09/202618Ioana Ilie (NL)Computational design of peptides to inhibit protein aggregation: a multiscale viewFrancesco Colizzi (ES)Decoding PET Depolymerization with Molecular Dynamics SimulationsJose L. Munoz (UK)Experimental validation of extremophilic CAZYmes using AI-assisted microfluidics
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