Genomewide Association Studies of Pharmacogenomics
 Share
The version of the browser you are using is no longer supported. Please upgrade to a supported browser.Dismiss

 
View only
 
 
ABCDEFGHIJKLMNOPQRSTUVWXYZ
1
DATE ADDED TO CATALOG
PUBMEDID
FIRST AUTHOR
DATEJOURNALLINKSTUDY
DISEASE/TRAIT
INITIAL SAMPLE SIZE
REPLICATION SAMPLE SIZE
PLATFORM [SNPS PASSING QC]
ASSOCIATION COUNT
MAPPED_TRAIT
MAPPED_TRAIT_URI
STUDY ACCESSION
Updated_date
2
6/16/0817505501Kindmark A5/15/07
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/17505501
Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis.
Response to ximelagatran treatment (increased serum alanine aminotransferase levels)
74 European ancestry cases, 130 European ancestry treated controls
10 European ancestry cases, 16 European ancestry treated controls
Perlegen [~ 266722]
0
serum alanine aminotransferase measurement, response to ximelagatran
http://www.ebi.ac.uk/efo/EFO_0004735, http://purl.obolibrary.org/obo/GO_0036288
GCST000034
7/10/2017
3
9/28/0918195134Byun E1/14/08Arch Neurol
www.ncbi.nlm.nih.gov/pubmed/18195134
Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.
Response to interferon beta therapy
99 European ancestry responders, 107 European ancestry non-responders
81 European ancestry individuals
Affymetrix [~ 100000]
0
response to interferon beta
http://purl.obolibrary.org/obo/GO_0035456
GCST000140
7/10/2017
4
6/22/0818521090Lavedan C6/3/08
Mol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/18521090
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.
Response to iloperidone treatment (PANSS-T score)
106 Asian, African American, European, or other ancestry individuals
104 Asian, African American, European, or other ancestry individuals
Affymetrix [334563]
0
response to iloperidone
http://purl.obolibrary.org/obo/GO_0036287
GCST000200
7/10/2017
5
6/22/0818521091Volpi S6/3/08
Mol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/18521091
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
Response to iloperidone treatment (QT prolongation)
91 African American Schizophrenia cases, 69 European ancestry Schizophrenia cases, 16 Asian ancestry Schizophrenia cases, 7 Schizophrenia cases
NA
Affymetrix [339272]
6
response to iloperidone
http://purl.obolibrary.org/obo/GO_0036287
GCST000201
7/10/2017
6
6/26/0818535201Cooper GM6/5/08Blood
www.ncbi.nlm.nih.gov/pubmed/18535201
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
Warfarin maintenance dose
181 European ancestry individuals
374 European ancestry individuals
Illumina [538629]
3
response to anticoagulant
http://purl.obolibrary.org/obo/GO_0061476
GCST000204
7/10/2017
7
9/3/0818591461Turner ST6/30/08Hypertension
www.ncbi.nlm.nih.gov/pubmed/18591461
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
Response to diuretic therapy
97 African American good response individuals, 97 African American poor response individuals, 98 European ancestry good response individuals, 97 European ancestry poor response individuals
NA
Affymetrix [up to 102334]
1
response to diruetic
http://purl.obolibrary.org/obo/GO_0036270
GCST000208
7/10/2017
8
8/7/0818615156Liu C7/10/08Mol Med
www.ncbi.nlm.nih.gov/pubmed/18615156
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
Response to TNF antagonist treatment
89 European ancestry cases
NA
Illumina [283348]
8
response to TNF antagonist
http://www.ebi.ac.uk/efo/EFO_0004653
GCST000211
7/10/2017
9
8/7/0818650507Link E7/23/08N Engl J Med
www.ncbi.nlm.nih.gov/pubmed/18650507
SLCO1B1 variants and statin-induced myopathy--a genomewide study.
Response to statin therapy
85 European ancestry cases, 90 European ancestry controls
21 European ancestry cases, 16,643 European ancestry controls
Illumina [316184]
1
response to statin
http://purl.obolibrary.org/obo/GO_0036273
GCST000213
7/10/2017
10
2/26/0919176441Yang JJ1/28/09JAMA
www.ncbi.nlm.nih.gov/pubmed/19176441
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
Response to treatment for acute lymphoblastic leukemia
356 European ancestry cases, 53 Black cases, 78 cases
NA
Affymetrix [476796]
12
acute lymphoblastic leukemia, response to antineoplastic agent
http://www.ebi.ac.uk/efo/EFO_0000220, http://purl.obolibrary.org/obo/GO_0097327
GCST000323
7/10/2017
11
3/30/0919300499Takeuchi F3/20/09PLoS Genet
www.ncbi.nlm.nih.gov/pubmed/19300499
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.
Warfarin maintenance dose
1,053 European ancestry individuals
588 European ancestry individuals
Illumina [325997]
4
response to anticoagulant
http://purl.obolibrary.org/obo/GO_0061476
GCST000360
7/10/2017
12
6/1/0919448189Perlis RH5/15/09
Am J Psychiatry
www.ncbi.nlm.nih.gov/pubmed/19448189
A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.
Response to lithium treatment in bipolar disorder
458 lithium-treated cases, 719 non-lithium treated cases
359 European ancestry lithium-treated cases
Affymetrix [~ 1400000] (imputed)
0
response to lithium ion
http://purl.obolibrary.org/obo/GO_0010226
GCST000402
7/10/2017
13
6/15/0919483685Daly AK5/31/09Nat Genet
www.ncbi.nlm.nih.gov/pubmed/19483685
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
Drug-induced liver injury (flucloxacillin)
58 European ancestry cases, 282 European ancestry controls
NA
Illumina [866399]
6
drug-induced liver injury
http://www.ebi.ac.uk/efo/EFO_0004228
GCST000415
7/10/2017
14
7/24/0919578179Teichert M7/4/09
Hum Mol Genet
www.ncbi.nlm.nih.gov/pubmed/19578179
A genome-wide association study of acenocoumarol maintenance dosage.
Acenocoumarol maintenance dosage
1,451 European ancestry individuals
287 individuals
Illumina [~ 550000]
4
response to anticoagulant
http://purl.obolibrary.org/obo/GO_0061476
GCST000436
7/10/2017
15
9/4/0919667218Comabella M8/1/09Arch Neurol
www.ncbi.nlm.nih.gov/pubmed/19667218
Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.
Response to interferon beta therapy
53 responders, 53 non-responders
49 responders, 45 non-responders
Affymetrix [428867]
0
response to interferon beta
http://purl.obolibrary.org/obo/GO_0035456
GCST000453
7/10/2017
16
9/4/0919680635Alkelai A8/13/09
Psychopharmacology (Berl)
www.ncbi.nlm.nih.gov/pubmed/19680635
Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients.
Response to antipsychotic treatment
140 European ancestry cases, 117 European ancestry controls, 57 African American cases, 72 African American controls, 2 cases, 9 controls
NA
Affymetrix, Perlegen [495172]
1
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST000462
7/10/2017
17
9/9/0919706858Shuldiner AR8/26/09JAMA
www.ncbi.nlm.nih.gov/pubmed/19706858
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
Response to clopidogrel therapy
429 Amish individuals
140 European ancestry individuals, 83 African American individuals, 4 individuals
Affymetrix [400230]
1
response to platelet aggregation inhibitor
http://purl.obolibrary.org/obo/GO_0061478
GCST000467
7/10/2017
18
9/28/0919721433McClay JL9/1/09
Mol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/19721433
Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.
Response to antipsychotic treatment
494 European ancestry cases, 244 African American and other ancestry cases
NA
Affymetrix, Perlegen [492900]
9
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST000473
7/10/2017
19
9/9/0919724244Laje G8/31/09
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/19724244
Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
Response to antidepressant treatment
90 Hispanic and European ancestry cases, 90 Hispanic and European ancestry controls
30 Hispanic and European ancestry cases, 1,652 Hispanic and European ancestry controls
Illumina [100864]
0
response to antidepressant
http://purl.obolibrary.org/obo/GO_0036276
GCST000470
7/10/2017
20
9/29/0919736353Ising M9/1/09
Arch Gen Psychiatry
www.ncbi.nlm.nih.gov/pubmed/19736353
A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.
Response to antidepressant treatment
700 European ancestry cases
832 European ancestry cases, 366 European ancestry controls
Illumina [389251]
0
response to antidepressant
http://purl.obolibrary.org/obo/GO_0036276
GCST000471
7/10/2017
21
11/25/0919846067Garriock HA10/19/09
Biol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/19846067
A genomewide association study of citalopram response in major depressive disorder.
Response to citalopram treatment
Up to 659 European ancestry responders, up to 121 African American responders, up to 103 Hispanic responders, 408 European ancestry non-responders, 120 African American non-responders, 80 Hispanic non-responders
NA
Affymetrix [430198]
7
response to antidepressant
http://purl.obolibrary.org/obo/GO_0036276
GCST000509
7/10/2017
22
11/30/0919875103Aberg K10/27/09
Biol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/19875103
Genomewide association study of movement-related adverse antipsychotic effects.
Response to antipsychotic therapy (extrapyramidal side effects)
421 European ancestry schizophrenia cases, 214 African American schizophrenia cases, 103 schizophrenia cases
NA
Affymetrix [492000]
17
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST000514
7/10/2017
23
9/24/1319901119Trevino LR11/9/09J Clin Oncol
www.ncbi.nlm.nih.gov/pubmed/19901119
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
Methotrexate phramacokinetics (acute lymphoblastic leukemia)
315 European ancestry cases, 73 African American cases, 5 Asian ancestry cases, 247 cases
NA
Affymetrix [398699]
21
response to antineoplastic agent
http://purl.obolibrary.org/obo/GO_0097327
GCST000523
7/10/2017
24
8/16/1320014019Dubinsky MC8/1/10
Inflamm Bowel Dis
www.ncbi.nlm.nih.gov/pubmed/20014019
Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.
Response to anti-TNF alpha therapy in inflammatory bowel disease
94 pediatric cases
NA
Illumina [301742]
4
response to TNF antagonist
http://www.ebi.ac.uk/efo/EFO_0004653
GCST000748
7/10/2017
25
12/29/0920031582Thompson JF4/1/09
Circ Cardiovasc Genet
www.ncbi.nlm.nih.gov/pubmed/20031582
Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.
Response to statin therapy
1,984 European ancestry individuals
3,761 European ancestry individuals, 1,248 individuals
Perlegen [291998]
0
response to statin
http://purl.obolibrary.org/obo/GO_0036273
GCST000369
7/10/2017
26
4/6/1020195266Adkins DE3/2/10
Mol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/20195266
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
Response to antipsychotic treatment
421 European ancestry, 214 African American, and 103 cases
NA
Affymetrix [492900]
37
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST000618
7/10/2017
27
3/29/1020235792Uhl GR3/1/10
Pharmacogenomics
www.ncbi.nlm.nih.gov/pubmed/20235792
Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement.
Smoking cessation
108 Abstinent individuals , 216 Non-abstinent individuals
NA
Affymetrix [NR]
0
smoking cessation
http://www.ebi.ac.uk/efo/EFO_0004319
GCST000616
7/10/2017
28
4/14/1020339536Barber MJ3/22/10PLoS One
www.ncbi.nlm.nih.gov/pubmed/20339536
Genome-wide association of lipid-lowering response to statins in combined study populations.
Response to statin therapy
3,928 European ancestry individuals
NA
Illumina [~ 2500000] (imputed)
36
response to statin
http://purl.obolibrary.org/obo/GO_0036273
GCST000635
7/10/2017
29
5/3/1020360315Uher R4/1/10
Am J Psychiatry
www.ncbi.nlm.nih.gov/pubmed/20360315
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
Response to antidepressants
706 European ancestry individuals
NA
Illumina [539391]
8
response to antidepressant
http://purl.obolibrary.org/obo/GO_0036276
GCST000643
7/10/2017
30
6/14/1020463552Wu C6/1/10
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/20463552
Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy in patients with small-cell lung cancer.
Response to platinum-based chemotherapy in small-cell lung cancer
245 Han Chinese ancestry cases
183 Han Chinese ancestry cases
Affymetrix [265996]
0
response to platinum based chemotherapy
http://www.ebi.ac.uk/efo/EFO_0004647
GCST000688
7/10/2017
31
11/9/1320592726Chen SH6/30/10
Clin Pharmacol Ther
www.ncbi.nlm.nih.gov/pubmed/20592726
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
Asparaginase hypersensitivity in acute lymphoblastic leukemia
211 European ancestry child cases, 40 Black child cases, 46 Hispanic child cases, 4 Asian ancestry child cases, 21 child cases
99 European ancestry child cases, 33 Black child cases, 24 Hispanic child cases, 2 Asian ancestry child cases, 5 child cases
Affymetrix [364033]
1
asparaginase hypersensitivity
http://www.ebi.ac.uk/efo/EFO_0004881
GCST000715
7/10/2017
32
9/1/1020637204Ochi H7/13/10
Gastroenterology
www.ncbi.nlm.nih.gov/pubmed/20637204
ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.
Ribavirin-induced anemia
453 Japanese ancestry individuals
470 Japanese ancestry individuals
Illumina [510537]
1
anemia, response to ribavirin
http://www.ebi.ac.uk/efo/EFO_0004272, http://purl.obolibrary.org/obo/GO_1901559
GCST000729
7/10/2017
33
9/2/1020639878Singer JB7/18/10Nat Genet
www.ncbi.nlm.nih.gov/pubmed/20639878
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.
Lumiracoxib-related liver injury
31 European ancestry cases, 3 Hispanic cases, 1 case, 176 European, Hispanic and other ancestry controls
79 European ancestry cases, 16 Hispanic ancestry cases, 1 case, 405 European, Hispanic and other ancestry controls
Affymetrix [682386]
1
drug-induced liver injury
http://www.ebi.ac.uk/efo/EFO_0004228
GCST000735
7/10/2017
34
9/24/1020811658Uhl GR8/24/10Mol Med
www.ncbi.nlm.nih.gov/pubmed/20811658
Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.
Smoking cessation
369 European ancestry individuals
NA
Affymetrix [905273]
1
smoking cessation
http://www.ebi.ac.uk/efo/EFO_0004319
GCST000778
7/10/2017
35
10/5/1020833655Cha PC9/10/10
Hum Mol Genet
www.ncbi.nlm.nih.gov/pubmed/20833655
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
Warfarin maintenance dose
807 Japanese ancestry low dose individuals, 701 Japanese ancestry high dose individuals
444 Japanese ancestry individuals
Illumina [485227]
5
response to anticoagulant
http://purl.obolibrary.org/obo/GO_0061476
GCST000792
7/10/2017
36
10/15/1020876420Ingle JN9/27/10J Clin Oncol
www.ncbi.nlm.nih.gov/pubmed/20876420
Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.
Adverse response to aromatase inhibitors
293 cases, 585 controls
NA
Illumina [551395]
1
response to aromatase inhibitor
http://purl.obolibrary.org/obo/GO_0061477
GCST000813
7/10/2017
37
11/5/1020921969Aberg K10/5/10
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/20921969
Genome-wide association study of antipsychotic-induced QTc interval prolongation.
Antipsychotic-induced QTc interval prolongation
738 European, African American, Hispanic, and other ancestry Schizophrenia cases
NA
Affymetrix [492000]
3
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST000822
7/10/2017
38
11/23/1020923822Niu N10/5/10Genome Res
www.ncbi.nlm.nih.gov/pubmed/20923822
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
Radiation response
93 African American human lymphoblastoid cell lines, 89 European ancestry human lymphoblastoid cell lines, 95 Han Chinese ancestry human lymphoblastoid cell lines
NA
Affymetrix, Illumina [1348798]
12
response to radiation
http://purl.obolibrary.org/obo/GO_0009314
GCST000823
7/10/2017
39
11/15/1020932654Kerns SL10/5/10
Int J Radiat Oncol Biol Phys
www.ncbi.nlm.nih.gov/pubmed/20932654
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
Erectile dysfunction and prostate cancer treatment
27 African American cases, 52 African American controls
NA
Affymetrix [512497]
23
response to radiation, prostate carcinoma, erectile dysfunction
http://purl.obolibrary.org/obo/GO_0009314, http://www.ebi.ac.uk/efo/EFO_0001663, http://www.ebi.ac.uk/efo/EFO_0004234
GCST000824
7/10/2017
40
1/4/1121061259Plant D11/8/10
Arthritis Rheum
www.ncbi.nlm.nih.gov/pubmed/21061259
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.
Response to anti-TNF therapy in rheumatoid arthritis
566 European ancestry individuals
720 European ancestry individuals
Affymetrix [459446]
0
response to TNF antagonist
http://www.ebi.ac.uk/efo/EFO_0004653
GCST000865
7/10/2017
41
1/12/1121106707Gu J11/24/10
Hum Mol Genet
www.ncbi.nlm.nih.gov/pubmed/21106707
A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.
Response to bleomycin (chromatid breaks)
673 European ancestry individuals
834 European ancestry individuals
Illumina [539437]
3
response to bleomycin, chromatid break measurement, response to antibiotic
http://www.ebi.ac.uk/efo/EFO_0007592, http://www.ebi.ac.uk/efo/EFO_0007593, http://purl.obolibrary.org/obo/GO_0046677
GCST000882
7/10/2017
42
1/8/1121107309McClay JL11/24/10
Neuropsychopharmacology
www.ncbi.nlm.nih.gov/pubmed/21107309
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
Response to antipsychotic treatment
738 European ancestry, African American, and other ancestry cases
NA
Affymetrix [492900]
2
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST000884
7/10/2017
43
7/1/1421130132Mick E12/1/10
Prog Neuropsychopharmacol Biol Psychiatry
www.ncbi.nlm.nih.gov/pubmed/21130132
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure)
140 child cases
NA
Affymetrix [316934]
7
response to methylphenidate
http://purl.obolibrary.org/obo/GO_0036271
GCST000903
7/10/2017
44
1/10/1121149285Ozeki T12/10/10
Hum Mol Genet
www.ncbi.nlm.nih.gov/pubmed/21149285
Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.
Adverse response to carbamapezine
53 Japanese ancestry cases, 881 Japanese ancestry controls
23 Japanese ancestry cases, 44 Japanese ancestry controls
Illumina [444823]
1
response to anticonvulsant
http://purl.obolibrary.org/obo/GO_0036277
GCST000912
7/10/2017
45
1/18/1121177773Moyer AM12/22/10Toxicol Sci
www.ncbi.nlm.nih.gov/pubmed/21177773
Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
Response to acetaminophen (hepatotoxicity)
60 European ancestry lymphoblastoid cell lines, 56 African American lymphoblastoid cell lines, 60 Han Chinese American lymphoblastoid cell lines
NA
Affymetrix, Illumina [1348864]
5
response to acetaminophen
http://purl.obolibrary.org/obo/GO_1901554
GCST000924
7/10/2017
46
1/16/1121186350Zhou K12/26/10Nat Genet
www.ncbi.nlm.nih.gov/pubmed/21186350
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Response to metformin in type 2 diabetes (glycemic)
1,024 European ancestry cases
2,896 European ancestry cases
Affymetrix [705125]
1
response to metformin
http://purl.obolibrary.org/obo/GO_1901558
GCST000927
7/10/2017
47
5/20/1521221126Shen Y1/11/11
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/21221126
Genome-wide association study of serious blistering skin rash caused by drugs.
Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN)
up to 72 European ancestry cases, up to 4,251 European ancestry controls
NA
Illumina [up to 1000000]
4
Stevens-Johnson syndrome, toxic epidermal necrolysis
http://www.ebi.ac.uk/efo/EFO_0004276, http://www.ebi.ac.uk/efo/EFO_0004775
GCST000942
7/10/2017
48
3/1/1121245432Spraggs CF1/24/11J Clin Oncol
www.ncbi.nlm.nih.gov/pubmed/21245432
HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.
Lapatinib-induced hepatotoxicity in breast cancer
26 European ancestry cases, 11 cases, 196 European ancestry controls, 90 controls
21 European ancestry cases, 3 cases, 123 European ancestry controls, 32 controls
Illumina [1111203]
0
response to lapatinib
http://purl.obolibrary.org/obo/GO_0036274
GCST000953
7/10/2017
49
5/21/1521386754Marciante KD3/6/11
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/21386754
Cerivastatin, genetic variants, and the risk of rhabdomyolysis.
Cerivastatin-induced rhabdomyolysis
168 European ancestry cases, 636 European ancestry controls, 17 cases, 96 controls
NA
Illumina [292461]
1
response to statin, rhabdomyolysis
http://purl.obolibrary.org/obo/GO_0036273, http://www.ebi.ac.uk/efo/EFO_0003867
GCST001002
7/10/2017
50
4/13/1121396408Miller EK3/25/11Vaccine
www.ncbi.nlm.nih.gov/pubmed/21396408
Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age.
Vaccine-related adverse events
6 European ancestry cases,55 European ancestry controls
NA
Illumina [468458]
2
response to vaccine
http://www.ebi.ac.uk/efo/EFO_0004645
GCST001016
7/10/2017
51
4/13/1121428769
McCormack M
3/24/11N Engl J Med
www.ncbi.nlm.nih.gov/pubmed/21428769
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
Adverse response to carbamapezine
65 European ancestry cases, 3,987 European ancestry controls
80 European ancestry cases, 257 European ancestry controls
Illumina [~ 1200000] (imputed)
1
response to anticonvulsant
http://purl.obolibrary.org/obo/GO_0036277
GCST001014
7/10/2017
52
5/11/1121483023Wu X4/11/11
J Natl Cancer Inst
www.ncbi.nlm.nih.gov/pubmed/21483023
Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.
Response to platinum-based chemotherapy in non-small-cell lung cancer
327 European ancestry individuals
735 European ancestry individuals
Illumina [307260]
1
response to platinum based chemotherapy, non-small cell lung carcinoma
http://www.ebi.ac.uk/efo/EFO_0004647, http://www.ebi.ac.uk/efo/EFO_0003060
GCST001035
7/10/2017
53
4/25/1321497773Ziliak D2/8/11Transl Res
www.ncbi.nlm.nih.gov/pubmed/21497773
Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers.
Response to platinum-based chemotherapy in head and neck cancers
90 European ancestry Lymphoblastoid cell lines
NA
NR [~ 2000000]
0
response to platinum based chemotherapy
http://www.ebi.ac.uk/efo/EFO_0004647
GCST000967
7/10/2017
54
4/24/1321497773Ziliak D2/8/11Transl Res
www.ncbi.nlm.nih.gov/pubmed/21497773
Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers.
Response to platinum-based chemotherapy in head and neck cancers
90 East Asian ancestry lymphoblastoid cell lines
90 European ancestry lymphoblastoid cell lines, 59 Yoruban ancestry lymphoblastoid cell lines
NR [~ 2000000]
0
response to platinum based chemotherapy
http://www.ebi.ac.uk/efo/EFO_0004647
GCST000968
7/10/2017
55
5/25/1121502966Weber F4/19/11
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/21502966
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
Response to interferon beta therapy
178 European ancestry antibody-positive individuals, 184 European ancestry antibody-negative individuals
350 European ancestry antibody-positive individuals, 468 European ancestry antibody-negative individuals
Illumina [~ 317000]
2
response to interferon beta
http://purl.obolibrary.org/obo/GO_0035456
GCST001043
7/10/2017
56
5/27/1121570397Lucena MI4/12/11
Gastroenterology
www.ncbi.nlm.nih.gov/pubmed/21570397
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.
Drug-induced liver injury (amoxicillin-clavulanate)
201 European ancestry cases, 532 European ancestry controls
NA
Illumina [822927]
2
drug-induced liver injury
http://www.ebi.ac.uk/efo/EFO_0004228
GCST001036
7/10/2017
57
6/25/1121659360Wade R6/9/11
Haematologica
www.ncbi.nlm.nih.gov/pubmed/21659360
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
Response to antineoplastic agents
356 European ancestry cases
380 European ancestry cases
Illumina [326385]
9
response to antineoplastic agent
http://purl.obolibrary.org/obo/GO_0097327
GCST001095
7/10/2017
58
4/24/1321705454Huang RS6/24/11
Clin Cancer Res
www.ncbi.nlm.nih.gov/pubmed/21705454
Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
Response to platinum-based agents
87 European ancestry lymphoblastoid cell lines
52 European ancestry lymphoblastoid cell lines
NR [2286186]
0
response to platinum based chemotherapy
http://www.ebi.ac.uk/efo/EFO_0004647
GCST001127
7/10/2017
59
7/29/1121755009Wheeler HE7/6/11PLoS One
www.ncbi.nlm.nih.gov/pubmed/21755009
Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
Chemotherapeutic susceptibility
83 African American lymphoblastoid cell lines, 176 African ancestry lymphoblastoid cell lines
NA
NR [2217232] (imputed)
0
response to antineoplastic agent
http://purl.obolibrary.org/obo/GO_0097327
GCST001145
7/10/2017
60
8/6/1121764829Png E7/15/11
Hum Mol Genet
www.ncbi.nlm.nih.gov/pubmed/21764829
A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.
Hepatitis B vaccine response
1,683 Indonesian ancestry individuals
1,931 Indonesian ancestry individuals
Illumina [455508]
3
response to vaccine
http://www.ebi.ac.uk/efo/EFO_0004645
GCST001162
7/10/2017
61
10/1/1121775533Tan XL7/20/11
Clin Cancer Res
www.ncbi.nlm.nih.gov/pubmed/21775533
Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy.
Response to platinum-based chemotherapy in small cell and non-small cell lung cancers
91 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese ancestry lymphoblastoid cell lines
222 European ancestry small cell lung cancer cases, 961 European ancestry non-small cell lung cancer cases
Affymetrix, Illumina [1348798]
0
response to platinum based chemotherapy
http://www.ebi.ac.uk/efo/EFO_0004647
GCST001169
7/10/2017
62
9/8/1121799462Srinivasan Y7/27/11
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/21799462
Genome-wide association study of epirubicin-induced leukopenia in Japanese patients.
Epirubicin-induced leukopenia
67 Japanese ancestry cases, 203 Japanese ancestry controls
48 Japanese ancestry cases
Illumina [478359]
2leukopenia
http://www.ebi.ac.uk/efo/EFO_0004233
GCST001175
7/10/2017
63
5/20/1521801394Genin E7/29/11
Orphanet J Rare Dis
www.ncbi.nlm.nih.gov/pubmed/21801394
Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.
Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN)
424 European ancestry cases, 1,881 European ancestry controls
NA
Illumina [268914]
6
Stevens-Johnson syndrome, toxic epidermal necrolysis
http://www.ebi.ac.uk/efo/EFO_0004276, http://www.ebi.ac.uk/efo/EFO_0004775
GCST001181
7/10/2017
64
9/6/1121810746
Chantarangsu S
8/1/11Clin Infect Dis
www.ncbi.nlm.nih.gov/pubmed/21810746
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
Nevirapine-induced rash
72 Thai ancestry nevirapine-induced rash HIV cases, 77 Thai ancestry nevirapine-tolerant rash HIV cases
88 Thai ancestry nevirapine-induced rash HIV cases, 145 Thai ancestry nevirapine-tolerant HIV cases
Illumina [499730]
3
response to reverse transcriptase inhibitor
http://purl.obolibrary.org/obo/GO_0061479
GCST001186
7/10/2017
65
9/15/1121826682Isackson PJ8/8/11Muscle Nerve
www.ncbi.nlm.nih.gov/pubmed/21826682
Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS.
Response to statin therapy
39 European ancestry severe statin myopathy cases, 40 European ancestry controls
67 European ancestry severe statin myopathy cases, 42 European ancestry controls
Affymetrix [NR]
0
response to statin
http://purl.obolibrary.org/obo/GO_0036273
GCST001192
7/10/2017
66
4/16/1521844884Wheeler8/16/11
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/21844884
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
Response to platinum-based chemotherapy (carboplatin)
176 Sub-Saharan African ancestry lymphoblastoid cell lines, 83 African ancestry lymphoblastoid cell lines, 175 East Asian ancestry lymphoblastoid cell lines, 174 European ancestry lymphoblastoid cell lines
NA
NR [~ 3000000] (imputed)
18
response to carboplatin
http://purl.obolibrary.org/obo/GO_0097328
GCST001204
7/10/2017
67
4/16/1521844884Wheeler8/16/11
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/21844884
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
Response to platinum-based chemotherapy (cisplatin)
176 Sub-Saharan African ancestry lymphoblastoid cell lines, 83 African ancestry lymphoblastoid cell lines, 175 East Asian ancestry lymphoblastoid cell lines, 174 European ancestry lymphoblastoid cell lines
NA
NR [~ 3000000] (imputed)
21
response to cisplatin
http://purl.obolibrary.org/obo/GO_0072718
GCST001201
7/10/2017
68
9/17/1121845381Florez JC8/16/11
Curr Diab Rep
www.ncbi.nlm.nih.gov/pubmed/21845381
Does metformin work for everyone? A genome-wide association study for metformin response.
Response to metformin
1,014 European ancestry individuals, 10 individuals
2,896 European ancestry individuals
Affymetrix [705125]
1
response to metformin
http://purl.obolibrary.org/obo/GO_1901558
GCST001202
7/10/2017
69
10/29/1121961650Squassina A10/3/11
Pharmacogenomics
www.ncbi.nlm.nih.gov/pubmed/21961650
Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder.
Response to lithium treatment in bipolar disorder
26 European ancestry lithium treatment responders, 26 European ancestry lithium treatment non-responders
34 European ancestry lithium treatment responders, 118 European ancestry lithium treatment non-responders
Affymetrix [645148]
0
response to lithium ion
http://purl.obolibrary.org/obo/GO_0010226
GCST001259
7/10/2017
70
11/4/1121990027Drago A10/11/11
Am J Med Genet B Neuropsychiatr Genet
www.ncbi.nlm.nih.gov/pubmed/21990027
The genetics of antipsychotic induced tremors: a genome-wide pathway analysis on the STEP-BD SCP sample.
Response to antipsychotic therapy (extrapyramidal side effects)
409 European and other ancestry bipolar cases
NA
Affymetrix [NR]
1
response to antipsychotic drug
http://purl.obolibrary.org/obo/GO_0097332
GCST001271
7/10/2017
71
11/16/1121991891Tantisira KG9/26/11N Engl J Med
www.ncbi.nlm.nih.gov/pubmed/21991891
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
Asthma treatment response
1,169 European ancestry child and parent asthmatic cases
935 European ancestry adult asthmatic cases
Illumina [534290]
0
response to glucocorticoid
http://purl.obolibrary.org/obo/GO_0051384
GCST001252
7/10/2017
72
11/24/1122020760Won HH10/21/11Cancer
www.ncbi.nlm.nih.gov/pubmed/22020760
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.
Response to platinum-based agents
96 colon cancer cases
247 colon cancer cases
Affymetrix [656843]
3
response to platinum based chemotherapy
http://www.ebi.ac.uk/efo/EFO_0004647
GCST001291
7/10/2017
73
5/14/1522041458Clark SL11/1/11Psychol Med
www.ncbi.nlm.nih.gov/pubmed/22041458
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
Response to anti-depressant treatment in major depressive disorder
1,151 European ancestry cases, 288 African American cases
NA
Affymetrix [421789]
22
response to antidepressant
http://purl.obolibrary.org/obo/GO_0036276
GCST001308
7/10/2017
74
1/6/1222142827Innocenti F12/5/11
Clin Cancer Res
www.ncbi.nlm.nih.gov/pubmed/22142827
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
Response to gemcitabine in pancreatic cancer
294 European ancestry cases
NA
Illumina [330690]
3
response to gemcitabine, pancreatic carcinoma
http://purl.obolibrary.org/obo/GO_0036272, http://www.ebi.ac.uk/efo/EFO_0002618
GCST001346
7/10/2017
75
1/14/1222180457Kiyotani K12/16/11
Hum Mol Genet
www.ncbi.nlm.nih.gov/pubmed/22180457
A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese.
Response to tamoxifen in breast cancer
240 Japanese ancestry female cases
222 Japanese ancestry female cases
Illumina [470796]
1
response to antineoplastic agent
http://purl.obolibrary.org/obo/GO_0097327
GCST001357
7/10/2017
76
3/10/1222228203Aslibekyan S1/5/12
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/22228203
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
Inflammatory biomarkers
1,092 European ancestry individuals
NA
Affymetrix [2543887] (imputed)
19
response to fenofibrate
http://purl.obolibrary.org/obo/GO_1901557
GCST001371
7/10/2017
77
3/23/1222293537Kiyotani K1/29/12
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/22293537
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
Response to gemcitabine in pancreatic cancer
21 Japanese ancestry adverse reaction cases, 58 Japanese ancestry non-adverse reaction individuals
33 Japanese ancestry adverse reaction cases, 62 Japanese ancestry non-adverse reaction individuals
Illumina [470064]
2
response to gemcitabine, pancreatic carcinoma
http://purl.obolibrary.org/obo/GO_0036272, http://www.ebi.ac.uk/efo/EFO_0002618
GCST001390
7/10/2017
78
3/9/1222310351
Fernandez-Rozadilla C
2/7/12
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/22310351
Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration.
Fluorouracil treatment response in colorectal cancer
203 European ancestry cases
791 European ancestry cases
Affymetrix [497366]
0
response to 5' fluorouracil
http://purl.obolibrary.org/obo/GO_0036275
GCST001403
7/10/2017
79
3/13/1222310353Man M2/7/12
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/22310353
Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.
Treatment response for severe sepsis
1,446 individuals
NA
Illumina [856627]
8
response to drug
http://purl.obolibrary.org/obo/GO_0042493
GCST001402
7/10/2017
80
3/14/1222331829Chasman DI2/13/12
Circ Cardiovasc Genet
www.ncbi.nlm.nih.gov/pubmed/22331829
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
Response to statins (LDL cholesterol change)
6,989 European ancestry individuals
NA
Illumina [814418]
8
response to statin, LDL cholesterol change measurement
http://purl.obolibrary.org/obo/GO_0036273, http://www.ebi.ac.uk/efo/EFO_0007804
GCST001408
7/10/2017
81
3/17/1222368281
Deshmukh HA
2/24/12J Lipid Res
www.ncbi.nlm.nih.gov/pubmed/22368281
Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).
Response to statin therapy
2,702 European ancestry individuals
2,550 European ancestry individuals
Illumina, Perlegen [NR] (imputed)
1
response to statin
http://purl.obolibrary.org/obo/GO_0036273
GCST001425
7/10/2017
82
4/3/1222379998
McCormack M
3/1/12
Pharmacogenomics
www.ncbi.nlm.nih.gov/pubmed/22379998
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
Adverse response to lamotrigine and phenytoin
34 European ancestry lamotrigine-induced hypersensitivity cases, 42 European ancestry phenytoin-induced hypersensitivity cases, 1,296 European ancestry controls
NAIllumina [NR]12
response to anticonvulsant
http://purl.obolibrary.org/obo/GO_0036277
GCST001431
7/10/2017
83
4/6/1222417934Athanasiu L3/12/12
Psychiatry Res
www.ncbi.nlm.nih.gov/pubmed/22417934
Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study.
Body mass index and cholesterol (psychopharmacological treatment)
283 European ancestry schizophrenia cases, 213 European ancestry bipolar disorder cases, 98 European ancestry psychosis cases
NA
Affymetrix [608239]
2
total cholesterol measurement, response to drug, body mass index
http://www.ebi.ac.uk/efo/EFO_0004574, http://purl.obolibrary.org/obo/GO_0042493, http://www.ebi.ac.uk/efo/EFO_0004340
GCST001440
7/10/2017
84
6/18/1222437554Major JM3/21/12J Nutr
www.ncbi.nlm.nih.gov/pubmed/22437554
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
Response to Vitamin E supplementation
2,112 European ancestry individuals
NA
Illumina [549989]
8
response to vitamin
http://purl.obolibrary.org/obo/GO_0033273
GCST001450
7/10/2017
85
6/19/1222491018Wang J4/10/12
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/22491018
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
Response to tocilizumab in rheumatoid arthritis
1,157 European and other ancestry rheumatoid arthritis cases
526 European and other ancestry rheumatoid arthritis cases
Illumina [534053]
31
rheumatoid arthritis, response to drug
http://www.ebi.ac.uk/efo/EFO_0000685, http://purl.obolibrary.org/obo/GO_0042493
GCST001476
7/10/2017
86
7/4/1222542470
Ovsyannikova IG
4/25/12Vaccine
www.ncbi.nlm.nih.gov/pubmed/22542470
Genome-wide association study of antibody response to smallpox vaccine.
Immune response to smallpox vaccine (IL-6)
217 African American individuals, 580 European ancestry individuals, 217 Hispanic individuals
NAIllumina [NR]37
response to vaccine
http://www.ebi.ac.uk/efo/EFO_0004645
GCST001491
7/10/2017
87
7/21/1222566498Turner ST5/7/12Hypertension
www.ncbi.nlm.nih.gov/pubmed/22566498
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
Response to angiotensin II receptor blocker therapy
198 European ancestry hypertensive individuals, 193 African American hypertensive individuals
NA
Affymetrix [~ 2300000] (imputed)
20
response to candesartan, hypertension
http://purl.obolibrary.org/obo/GO_1901556, http://www.ebi.ac.uk/efo/EFO_0000537
GCST001520
7/10/2017
88
7/21/1222566498Turner ST5/7/12Hypertension
www.ncbi.nlm.nih.gov/pubmed/22566498
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy)
394 European ancestry hypertensive individuals, 193 African American hypertensive individuals
NA
Affymetrix [~ 2300000] (imputed)
5
response to candesartan, hypertension
http://purl.obolibrary.org/obo/GO_1901556, http://www.ebi.ac.uk/efo/EFO_0000537
GCST001518
7/10/2017
89
8/9/1222566560Malhotra AK5/7/12
Arch Gen Psychiatry
www.ncbi.nlm.nih.gov/pubmed/22566560
Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.
Antipsychotic drug-induced weight gain
77 European ancestry individuals, 32 African American individuals, 30 individuals
183 European ancestry individuals, 22 African American individuals
Illumina [803582]
1
antipsychotic drug related weight gain
http://www.ebi.ac.uk/efo/EFO_0004567
GCST001517
7/10/2017
90
7/10/1222569225Krintel SB5/6/12
Pharmacogenet Genomics
www.ncbi.nlm.nih.gov/pubmed/22569225
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
Response to TNF-alpha inhibitors in rheumatoid arthritis
196 European ancestry cases
NA
Illumina [486450]
8
rheumatoid arthritis, response to TNF antagonist
http://www.ebi.ac.uk/efo/EFO_0000685, http://www.ebi.ac.uk/efo/EFO_0004653
GCST001510
7/10/2017
91
7/11/1222584459Sasayama D5/15/12
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/22584459
Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder.
Response to antidepressants
92 Japanese ancestry cases
136 Japanese ancestry cases
Illumina [291512]
1
response to antidepressant
http://purl.obolibrary.org/obo/GO_0036276
GCST001528
7/10/2017
92
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune reponse to smallpox (secreted IL-12p40)
Up to 512 European ancestry individuals, up to 199 African American individuals
NAIllumina [NR]10
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001537
7/10/2017
93
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune reponse to smallpox (secreted IFN-alpha)
Up to 512 European ancestry individuals, up to 199 African American individuals
NAIllumina [NR]32
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001538
7/10/2017
94
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune reponse to smallpox (secreted TNF-alpha)
Up to 512 European ancestry individuals, up to 199 African American individuals
NAIllumina [NR]6
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001536
7/10/2017
95
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune response to smallpox vaccine (IL-6)
Up to 512 European ancestry individuals, 199 African American individuals
NAIllumina [NR]9
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001532
7/10/2017
96
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune reponse to smallpox (secreted IL-1beta)
Up to 512 European ancestry individuals, up to 199 African American individuals
NAIllumina [NR]13
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001533
7/10/2017
97
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune reponse to smallpox (secreted IL-10)
Up to 512 European ancestry individuals, up to 199 African American individuals
NAIllumina [NR]6
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001534
7/10/2017
98
8/7/1222610502Kennedy RB5/19/12Hum Genet
www.ncbi.nlm.nih.gov/pubmed/22610502
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Immune reponse to smallpox (secreted IL-2)
Up to 512 European ancestry individuals, up to 199 African American individuals
NAIllumina [NR]17
response to vaccine, cytokine measurement
http://www.ebi.ac.uk/efo/EFO_0004645, http://www.ebi.ac.uk/efo/EFO_0004873
GCST001535
7/10/2017
99
7/17/1222658931Pajewski NM5/30/12Vaccine
www.ncbi.nlm.nih.gov/pubmed/22658931
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
Immune response to anthrax vaccine
726 European ancestry individuals
NA
Affymetrix [736996]
8
response to vaccine
http://www.ebi.ac.uk/efo/EFO_0004645
GCST001547
7/10/2017
100
7/19/1222664479Han JY6/5/12
Pharmacogenomics J
www.ncbi.nlm.nih.gov/pubmed/22664479
A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer.
Response to irinotecan in non-small-cell lung cancer
101 non-small-cell lung cancer cases
146 non-small-cell lung cancer cases
Affymetrix [312230]
2
response to irinotecan, non-small cell lung carcinoma
http://www.ebi.ac.uk/efo/EFO_0004829, http://www.ebi.ac.uk/efo/EFO_0003060
GCST001558
7/10/2017
Loading...
 
 
 
Sheet1