Supplement 5 .xls

	A	B	C	D	E
1	© 2000-2020 QIAGEN. All rights reserved.
2	Categories	Diseases or Functions Annotation	p-value	Molecules	# Molecules
3	Cardiovascular Disease,Hereditary Disorder,Organismal Injury and Abnormalities	Short QT syndrome	0.000128	KCNJ2,KCNQ1,TRPM4	3
4	Connective Tissue Disorders,Developmental Disorder,Hematological Disease,Hereditary Disorder,Organismal Injury and Abnormalities	X-linked thrombocytopenia	0.000355	GATA1,WAS	2
5	Cancer,Hematological Disease,Immunological Disease,Organismal Injury and Abnormalities	Down syndrome related acute megakaryoblastic leukemia	0.00105	GATA1,mir-10	2
6	Cancer,Gastrointestinal Disease,Organismal Injury and Abnormalities	Metastatic salivary gland cancer	0.00105	AR,ERBB2	2
7	Cardiovascular Disease,Developmental Disorder,Hematological Disease,Organismal Injury and Abnormalities	Congenital anemia	0.0012	ANXA1,AR,GATA1,HK1,RPL5,RRM2,TXNRD1	7
8	Cancer,Organismal Injury and Abnormalities	Endometrioid carcinoma	0.00134	AR,ELF3,H3-5,KMT2B,MAP3K1,mir-10,RPL5,RRM2,SPINT2,TUBB3,VHL	11
9	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Metastatic hormone receptor negative breast cancer	0.00169	AR,ERBB2,mir-10,RRM2,TUBB3	5
10	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Relapsed metastatic breast cancer	0.00179	AR,ERBB2,RRM2,TUBB3	4
11	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Endometrial adenocarcinoma	0.00194	AR,CENPF,ELF3,ERBB2,H3-5,KMT2B,MAP3K1,MCM2,mir-10,RPL5,TP73,TUBB3,VHL	13
12	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Uterine endometrioid carcinoma	0.00232	AR,ELF3,H3-5,KMT2B,MAP3K1,mir-10,RPL5,TUBB3,VHL	9
13	Organismal Injury and Abnormalities	Damage of epithelial tissue	0.00293	CYTH2,FGF7,PTK2B,SPHK1,TRIM72,ZG16B	6
14	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Relapsed estrogen receptor negative HER2 positive progesterone receptor negative breast cancer	0.00311	ERBB2,RRM2,TUBB3	3
15	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Progressive estrogen receptor negative HER2 positive progesterone receptor negative breast cancer	0.00311	ERBB2,RRM2,TUBB3	3
16	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Refractory estrogen receptor negative HER2 positive progesterone receptor negative breast cancer	0.00311	ERBB2,RRM2,TUBB3	3
17	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Progressive HER2 positive metastatic breast cancer	0.00311	ERBB2,RRM2,TUBB3	3
18	Endocrine System Disorders,Hematological Disease,Organismal Injury and Abnormalities	Hypercalcemia	0.00373	ANXA1,RRM2,SLC34A1	3
19	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Metastatic HER2-negative breast cancer	0.00437	AR,ERBB2,mir-10,RRM2,TUBB3	5
20	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Metastatic estrogen receptor negative HER2 positive progesterone receptor negative breast cancer	0.00441	ERBB2,RRM2,TUBB3	3
21	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Recurrent metastatic breast cancer	0.00456	AR,ERBB2,RRM2,TUBB3	4
22	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Recurrent hormone receptor negative breast cancer	0.00456	AR,ERBB2,RRM2,TUBB3	4
23	Endocrine System Disorders,Inflammatory Disease,Inflammatory Response,Organismal Injury and Abnormalities,Reproductive System Disease	Hypophysitis	0.00507	ANXA1,AR	2
24	Cancer,Endocrine System Disorders,Gastrointestinal Disease,Organismal Injury and Abnormalities	Invasive pancreatic adenocarcinoma	0.00507	ERBB2,RRM2	2
25	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage II-III infiltrating ductal breast carcinoma	0.00516	ERBB2,RRM2,TUBB3	3
26	Cancer,Organismal Injury and Abnormalities	Pelvic adenocarcinoma	0.00525	AR,CENPF,ELF3,ERBB2,H3-5,ID1,KCNK2,KMT2B,MAP3K1,MCM2,mir-10,RPL5,RRM2,SPINT2,TP73,TUBB3,UPK3B,VHL	18
27	Cancer,Organismal Injury and Abnormalities	Adenosquamous carcinoma	0.00555	ERBB2,RRM2,SPHK1,TUBB3	4
28	Cardiovascular Disease,Hematological Disease,Organismal Injury and Abnormalities	Dyserythropoietic anemia or sideroblastic anemia	0.00584	ANXA1,GATA1,RRM2,SLC25A38,TRNT1	5
29	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Metastatic HER2 positive advanced breast cancer	0.00599	ERBB2,RRM2,TUBB3	3
30	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Recurrent metastatic triple negative breast cancer	0.00599	AR,RRM2,TUBB3	3
31	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage IIIC-IV breast adenocarcinoma	0.00689	ERBB2,RRM2,TUBB3	3
32	Cardiovascular Disease,Developmental Disorder,Hereditary Disorder,Organismal Injury and Abnormalities	Congenital long QT syndrome	0.00689	KCNJ2,KCNQ1,TRPM4	3
33	Cancer,Endocrine System Disorders,Organismal Injury and Abnormalities,Reproductive System Disease	Prostatic small cell neuroendocrine carcinoma	0.00689	AR,ERBB2,H3-5	3
34	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Skeletal and Muscular Disorders	Uterine leiomyosarcoma	0.00689	AR,RRM2,TUBB3	3
35	Cancer,Endocrine System Disorders,Gastrointestinal Disease,Organismal Injury and Abnormalities	Pancreatic head adenocarcinoma	0.00701	ERBB2,RRM2	2
36	Cardiovascular Disease,Developmental Disorder,Hematological Disease,Organismal Injury and Abnormalities	Congenital aplastic anemia	0.00715	ANXA1,AR,RPL5,RRM2,TXNRD1	5
37	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage II-IV invasive breast cancer	0.00729	AR,ERBB2,RRM2,TUBB3	4
38	Cancer,Endocrine System Disorders,Organismal Injury and Abnormalities,Reproductive System Disease	Refractory epithelial ovarian cancer	0.00787	ERBB2,RRM2,TUBB3	3
39	Cancer,Gastrointestinal Disease,Hepatic System Disease,Organismal Injury and Abnormalities	Advanced gallbladder cancer	0.00787	ERBB2,RRM2,TUBB3	3
40	Cardiovascular Disease,Organismal Injury and Abnormalities	Polymorphic ventricular tachycardia	0.00787	KCNJ2,KCNQ1,TRPM4	3
41	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	CD274 negative breast cancer	0.00787	ERBB2,RRM2,TUBB3	3
42	Developmental Disorder,Hereditary Disorder,Organismal Injury and Abnormalities,Renal and Urological Disease	Autosomal dominant polycystic kidney disease	0.00793	AR,COL14A1,CPE,FBLN1,ISLR,PRKG1	6
43	Cancer,Endocrine System Disorders,Organismal Injury and Abnormalities	Extrapulmonary small cell carcinoma	0.00794	AR,ERBB2,H3-5,TUBB3	4
44	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Metastatic HER2 negative hormone receptor negative breast cancer	0.00794	AR,mir-10,RRM2,TUBB3	4
45	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Prostatic intraepithelial tumor	0.00835	CACNG3,CX3CL1,ITGB4,KCNK2,NCOA7,PTGDS	6
46	Hereditary Disorder,Organismal Injury and Abnormalities,Renal and Urological Disease	Autosomal dominant kidney disease	0.00846	AR,CNNM2,COL14A1,CPE,FBLN1,ISLR,PRKG1	7
47	Cancer,Endocrine System Disorders,Gastrointestinal Disease,Organismal Injury and Abnormalities	Locally advanced pancreatic cancer	0.00893	ERBB2,RRM2,TUBB3	3
48	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Advanced EGFR mutation negative lung squamous cell carcinoma	0.00893	ERBB2,RRM2,TUBB3	3
49	Cancer,Hematological Disease,Immunological Disease,Organismal Injury and Abnormalities	Type M7 acute myeloid leukemia	0.00935	ANXA1,GATA1,mir-10,RRM2	4
50	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Lung squamous cell carcinoma	0.00953	AR,CENPF,ERBB2,H3-5,KMT2B,MAP3K1,MCM2,mir-10,PTK2B,RPL5,RRM2,SPHK1,TP73,TUBB3,VHL	15
51	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Locally advanced squamous cell lung cancer	0.0101	ERBB2,RRM2,TUBB3	3
52	Cancer,Gastrointestinal Disease,Organismal Injury and Abnormalities,Respiratory Disease	Hypopharyngeal squamous cell carcinoma	0.0101	ERBB2,mir-10,mir-199,RRM2,TUBB3	5
53	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage IV advanced breast cancer	0.0101	AR,ERBB2,RRM2,TUBB3	4
54	Cardiovascular Disease,Organismal Injury and Abnormalities	Long-QT syndrome	0.0101	AR,KCNJ2,KCNQ1,TRPM4	4
55	Cardiovascular Disease,Cardiovascular System Development and Function,Cell Morphology,Cellular Function and Maintenance,Organismal Injury and Abnormalities,Tissue Morphology	Permeability of endothelial cells	0.0109	CYTH2,PTK2B,SPHK1,ZG16B	4
56	Endocrine System Disorders,Organismal Injury and Abnormalities,Reproductive System Disease	Pituitary lesion	0.011	ANXA1,AR,ERBB2,HSD11B2,NCAM1	5
57	Developmental Disorder,Hereditary Disorder,Ophthalmic Disease,Organismal Injury and Abnormalities	Cone dystrophy	0.0113	CABP4,CDHR1,KCNV2	3
58	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Refractory metastatic breast cancer	0.0113	ERBB2,RRM2,TUBB3	3
59	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Stage IV recurrent squamous cell lung cancer	0.0113	ERBB2,RRM2,TUBB3	3
60	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Locally advanced invasive breast cancer	0.0113	ERBB2,RRM2,TUBB3	3
61	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Non-inflammatory breast adenocarcinoma	0.0113	ERBB2,RRM2,TUBB3	3
62	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Hormone-refractory malignant neoplasm of prostate	0.0113	ANXA1,AR,TUBB3	3
63	Cancer,Organismal Injury and Abnormalities	Stage IB squamous cell carcinoma	0.0113	ERBB2,RRM2,TUBB3	3
64	Cancer,Gastrointestinal Disease,Hepatic System Disease,Organismal Injury and Abnormalities	Unresectable advanced cholangiocarcinoma	0.0117	ERBB2,RRM2	2
65	Endocrine System Disorders,Organismal Injury and Abnormalities	Thyroid dyshormonogenesis	0.0117	FOXI1,SLC5A5	2
66	Cancer,Gastrointestinal Disease,Hepatic System Disease,Organismal Injury and Abnormalities	Metastatic gall bladder carcinoma	0.0117	ERBB2,RRM2	2
67	Cancer,Organismal Injury and Abnormalities,Renal and Urological Disease	Locally advanced bladder cancer	0.0117	ERBB2,RRM2	2
68	Cancer,Organismal Injury and Abnormalities	Growth of adenocarcinoma	0.0117	ID1,MAPKAPK3	2
69	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Stage I-III lung adenocarcinoma	0.0118	ERBB2,RRM2,TNRC6B,TUBB3	4
70	Cancer,Organismal Injury and Abnormalities	Metastatic head and neck tumor	0.0123	AR,ERBB2,NCAM1,RRM2,RUNX2,TUBB3	6
71	Cancer,Hereditary Disorder,Organismal Injury and Abnormalities,Reproductive System Disease	Hereditary breast and/or ovarian cancer	0.0123	AR,ERBB2,PMS1,RRM2,TUBB3	5
72	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage 4 invasive hormone receptor positive breast cancer	0.0126	AR,ERBB2,TUBB3	3
73	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage IV estrogen receptor positive progesterone receptor positive breast cancer	0.0126	AR,ERBB2,TUBB3	3
74	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Stage IV ALK and ROS1 rearrangement negative, BRAF and EGFR mutation negative squamous cell carcinoma of lung	0.0126	ERBB2,RRM2,TUBB3	3
75	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Recurrent invasive estrogen receptor positive breast cancer	0.0126	AR,ERBB2,TUBB3	3
76	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Hormone receptor negative invasive ductal breast cancer	0.0126	ERBB2,RRM2,TUBB3	3
77	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	Non-small cell lung adenosquamous carcinoma	0.0126	ERBB2,SPHK1,TUBB3	3
78	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage IV invasive estrogen receptor positive breast cancer	0.0126	AR,ERBB2,TUBB3	3
79	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage IV hormone receptor positive advanced breast cancer	0.0126	AR,ERBB2,TUBB3	3
80	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Invasive estrogen receptor positive progesterone receptor positive breast cancer	0.0126	AR,ERBB2,TUBB3	3
81	Cancer,Organismal Injury and Abnormalities	Recurrent primary peritoneal cancer	0.0126	ERBB2,RRM2,TUBB3	3
82	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Stage IV postmenopausal breast cancer	0.0126	AR,ERBB2,TUBB3	3
83	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Progesterone receptor-positive breast cancer	0.0126	AR,ERBB2,mir-10,mir-199,TUBB3	5
84	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Female genital tract adenocarcinoma	0.0128	AR,CENPF,ELF3,ERBB2,H3-5,KMT2B,MAP3K1,MCM2,mir-10,RPL5,RRM2,SPINT2,TP73,TUBB3,UPK3B,VHL	16
85	Cancer,Endocrine System Disorders,Organismal Injury and Abnormalities	Extrapulmonary neuroendocrine carcinoma	0.013	AR,ERBB2,H3-5,NCAM1,TUBB3	5
86	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Prostatic carcinoma	0.013	AR,CENPF,ERBB2,H3-5,ID1,KCNK2,RRM2,RUNX2,TP73,TUBB3	10
87	Cancer,Organismal Injury and Abnormalities,Tumor Morphology	Metastatic progressive carcinoma	0.0136	ERBB2,PTK2B,RRM2,TUBB3	4
88	Cancer,Gastrointestinal Disease,Hepatic System Disease,Organismal Injury and Abnormalities	Metastatic extrahepatic cholangiocarcinoma	0.0139	ERBB2,RRM2,TUBB3	3
89	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Recurrent estrogen receptor positive progesterone receptor positive breast cancer	0.0139	AR,ERBB2,TUBB3	3
90	Cancer,Gastrointestinal Disease,Hepatic System Disease,Organismal Injury and Abnormalities	Metastatic liver cholangiocarcinoma	0.0139	ERBB2,RRM2,TUBB3	3
91	Developmental Disorder,Neurological Disease,Organismal Injury and Abnormalities	Neuronal heterotopia	0.0145	NEDD4L,PAFAH1B1	2
92	Cardiovascular Disease,Organismal Injury and Abnormalities	Damage of endothelial tissue	0.0145	CYTH2,FGF7,PTK2B,SPHK1,ZG16B	5
93	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Uterine carcinoma	0.0154	AR,CENPF,ELF3,ERBB2,H3-5,KMT2B,MAP3K1,MCM2,mir-10,mir-199,RPL5,RRM2,TP73,TUBB3,VHL	15
94	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Invasive non-inflammatory breast cancer	0.0154	ERBB2,RRM2,TUBB3	3
95	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Unilateral breast adenocarcinoma	0.0154	ERBB2,RRM2,TUBB3	3
96	Cancer,Gastrointestinal Disease,Organismal Injury and Abnormalities	Metastatic oral lesion	0.0154	AR,ERBB2,TUBB3	3
97	Cancer,Organismal Injury and Abnormalities	Early stage squamous-cell carcinoma	0.0155	ERBB2,mir-10,mir-199,RRM2,TUBB3	5
98	Cancer,Organismal Injury and Abnormalities,Respiratory Disease	EGFR or ROS1 mutation positive non-small cell lung carcinoma	0.0166	ERBB2,PTK2B,RRM2,TUBB3	4
99	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease	Nonmetastatic hormone receptor negative breast cancer	0.017	ERBB2,RRM2,TUBB3	3
100	Cancer,Organismal Injury and Abnormalities,Reproductive System Disease,Tumor Morphology	Metastatic invasive breast cancer	0.017	ERBB2,RRM2,TUBB3	3