Longevity Interventions and Biological Pathways
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InsulinmTOR
Inflammation
Immune/ thymus
EpigeneticMitochondriaAutophagyCatabolismTelomere
ROS damage
Brain aging
P53/Apoptosis
OtherComment
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RapamycinXXX
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AspirinX
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MetforminXX
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MelatoninX
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DeprenylX
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ALK5 inhibitors
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Epitalon/EpithalaminX
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MitoQ/SkQXX
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Beta Lapachone (Pao d’Arco)
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Spermidine
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BerberineXXX
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Dinh lang (Policias fruticosum)
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Pterostilbene/Resveratrol
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Gynostemma pentaphyllum (jiao-gu-lan)X
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N-Acetyl Cysteine (NAC) / GlutathioneX
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Ashwagandhaweakanti-cortizol
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Turmeric / curcuminX
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C60 / C60OOXXX
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Oxytocin (not oral)
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J147 (a promising new Alzheimer’s drug)XX
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NR, NMN and NAD precursors
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Polyphenols from tea
tea blocks telomerase activation
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Polyphenols from olive and olive leafXX
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Flavinoids from blueberriesX
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Angiotensin inhibitorsX
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NLRP3 antibodies
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Acetyl L-CarnitineX
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PiracetamX
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DHEA
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Statin drugs
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Cardarine / GW501516 / PPAR agonists
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Dasatinib / Quercetin
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FOXO4-DRI
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AstaxanthinXXXX
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Momordica charantia (bitter melon)
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Gotu kolaXXX
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BacopaX
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Veronica officinalisX
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Reishi mushroom
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AstragalusXanti-allergy
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Astragalus extractsX
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Pine bark extract
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Ginseng
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ExerciseX
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Caloric restrictionXXX
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Intermittent fasting (various schedules)XXX
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Plasma transfusions from younger individuals
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Platelet-rich plasma
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Transplanted young thymus
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Transplanted young suprachiasmatic nucleus
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Comarum palustreXX
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Scuttelaria baicalensisX?XXanti-stress
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PQQXXX
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rosmarinus officinalisX
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FisetinXX
effectively removes senescent cells at doses of 30mg/per 1kg of body weight or higher (effect starts at about 15-20mg/1kg but is very weak at these doses), at doses of 30mg/1kg the effect is visible after 4 three-daily repetitions of 30x100mg per 100 kg of weight, spaced for every twoo weeks (ie. after 2 months)
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