Booking - Nicolas Tritsch - 2026-06-26

	A	B	C	E	F	G
1		Nicolas Tritsch
2		nicolas.tritsch@mcgill.ca
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4	Affiliation	Douglas Research Center, McGill University
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6	Title	Defining dopamine's role in movement
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8	Summary	Ever since the discovery that the degeneration of midbrain DA neurons (mDANs) projecting to the striatum underlies bradykinesia (i.e., slowness of movement) in Parkinson’s disease (PD), DA has become synonymous with motor vigor. However, the mechanisms through which DA contributes to the speed and amplitude of individual voluntary movements are still debated. Initial investigations suggested a somewhat slow or permissive role for DA, but recent experiments in rodents proposed a stronger and faster role for DA in the dynamic control of the gain of motor commands. In this presentation, I will describe our attempts at better understanding how dopamine contributes to motor vigor through the study of release patterns, lesions, and optogenetic and pharmacological manipulations under physiological conditions and in mouse models of PD. Our findings call into question the widely-held view that phasic fluctuations in extracellular dopamine control the vigor of ongoing movements, constraining the kinds of mechanisms and timescales that dopamine likely acts on to modify behavior.
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10		Vendredi 26 juin		Students & Postdocs lunch
11	10h30 - 11h00			Name	Lab	Restriction alimentaire
12	11h00 - 12h00	Talk	F-1455	Mia Miao	CE	Sans restriction
13	12h00 - 13h00	Lunch with students	F-5471	Emmeraude Tanguay	Vbp	Sans restriction
14	13h00 - 13h30	Martin Parent	F-6561-4	Laurie-Shan Verville	MP	Sans restriction
15	13h30 - 14h00	Benoit Labonté	F4561	Talha Khan	MP	Halal, pescatarian
16	14h00 - 14h30			Rouhollah	MP	Sans restriction
17	14h30 - 15h00	Martin Lévesque	F-6561-3	Lydia Saidi	MP	Halal, pescatarian
18	15h00 - 15h30	Vincent Breton-Provencher	F5577	Deepshikha Sen	CE	Végé
19	15h30 - 16h00	Caroline Menard	F4539	Pujitha Kurukuri	MP	Végé
20				Zohreh Vaziri	CE	Sans restriction
21	Liu...Tritsch, Nat Neuroscience, 2025			Marina Ihidoype	CP	Own lunch
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