生化所107-1專題討論
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A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers.
Nat Commun. 2018 Mar 15;9(1):1097
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A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.
Nat Commun. 2018 Jul 18;9(1):2794.
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A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Nat Biotechnol. 2018 Mar;36(3):258-264.
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A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies.
Nat Biotechnol. 2018 Sep;36(8):726-737.
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A molecular signature for anastasis, recovery from the brink of apoptotic cell death. J Cell Biol. 2017 Aug 2. pii: jcb.201706134.106-1
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A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Nat Cell Biol. 2017 Sep;19(9):1105-1115.
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A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease.
J Am Chem Soc. 2017 Oct 18;139(41):14783-14791.
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A thiol probe for measuring unfolded protein load and proteostasis in cells.
Nat Commun. 2017 Sep 7;8(1):474.
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A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Nat Cell Biol. 2017 Oct;19(10):1260-1273.
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Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria.
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1895-1900.
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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Cell Metab. 2017 Sep 5;26(3):576.
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Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.
Nat Commun. 2017 Jul 24;8:16013.
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Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.
Cell Metab. 2017 Feb 7;25(2):448-462.
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AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.
EMBO J. 2017 Apr 13;36(8):995-1010.
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
Nature. 2017 Dec 14;552(7684):194-199.
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AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species.
Cell Rep. 2017 Oct 3;21(1):1-9.
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An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.
Structure. 2017 Jul 5;25(7):967-977.e5.
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Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.
J Clin Invest. 2018 Aug 1;128(8):3630-3641.
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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.
Science. 2017 May 5;356(6337):513-519.
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Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth.
ACS Chem Biol. 2017 Aug 18;12(8):2085-2096.
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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.
Nat Nanotechnol. 2017 Sep;12(9):877-882.
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Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.
Mol Cell. 2017 Jul 6;67(1):55-70.e4.
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Autophagy maintains the metabolism and function of young and old stem cells.
Nature. 2017 Mar 9;543(7644):205-210.
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Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells.
J Cell Biol. 2018 Jun 4;217(6):2103-2119.
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Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.
Cell Metab. 2018 Aug 7;28(2):268-281.e4.
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Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Cell Host Microbe. 2018 Mar 14;23(3):421.
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Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.
Cell Host Microbe. 2018 Jan 10;23(1):27-40.e7.
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Bioengineering Bacterially Derived Immunomodulants: A Therapeutic Approach to Inflammatory Bowel Disease.
ACS Nano. 2017 Sep 5.
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Biotechnological mass production of DNA origami.
Nature. 2017 Dec 6;552(7683):84-87
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Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.
Mol Cell. 2017 Aug 3;67(3):433-446.e4.
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Mol Cell. 2017 May 18;66(4):517-532.e9.
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C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation.
Nat Commun. 2018 Jan 4;9(1):51.
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Caloric Restriction Promotes Structural and Metabolic Changes in the Skin.
Cell Rep. 2017 Sep 12;20(11):2678-2692.
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CaMKK2 Regulates Mechanosensitive Assembly of Contractile Actin Stress Fibers.
Cell Rep. 2018 Jul 3;24(1):11-19.
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CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Deliver Toxins to B-Lymphoma Cells.
J Am Chem Soc. 2017 Sep 13;139(36):12450-12458.
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Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules.
Nat Nanotechnol. 2017 Aug 21.
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Codon-specific translation reprogramming promotes resistance to targeted therapy.
Nature. 2018 Jun;558(7711):605-609.
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Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics.
Mol Cell. 2017 Nov 16;68(4):758-772.e4.
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Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.
Cell Metab. 2017 Mar 7;25(3):622-634.
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CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing.
Nat Commun. 2018 Jun 8;9(1):2231
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CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.
Cell Metab. 2017 Jul 5;26(1):243-255.e6.
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Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.
Elife. 2018 Jan 16;7.
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Deferoxamine suppresses esophageal squamous cell carcinoma cell growth via ERK1/2 mediated mitochondrial dysfunction.
Cancer Lett. 2018 Sep 28;432:132-143.
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Development of DNA Nanostructures for High-Affinity Binding to Human Serum Albumin.
J Am Chem Soc. 2017 May 31;139(21):7355-7362.
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DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
Cell Metab. 2018 Jun 5;27(6):1236-1248.e6.
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat Chem Biol. 2017 Jun;13(6):624-632.
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Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Cancer Cell. 2017 Apr 10;31(4):516-531.e10.
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
Cell Metab. 2017 May 2;25(5):1135-1146.e7.
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Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Cell. 2017 Jan 12;168(1-2):264-279.e15.
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Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.
Cancer Cell. 2017 Feb 13;31(2):256-269.
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Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy.
Nat Nanotechnol. 2017 Jul 17.
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Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide.
Oncogene. 2018 Feb 20.
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell. 2017 Aug 24;170(5):875-888.e20.
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EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.
Nature. 2017 Feb 16;542(7641):357-361.
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Evolution of a designed protein assembly encapsulating its own RNA genome.
Nature. 2017 Dec 21;552(7685):415-420.
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Extreme disorder in an ultrahigh-affinity protein complex.
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Nature. 2018 Mar 1;555(7694):61-66.
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Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1698-E1706.
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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Cell Metab. 2017 Oct 3;26(4):693.
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Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5592-7.
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GRID-seq reveals the global RNA-chromatin interactome.
Nat Biotechnol. 2017 Sep 18.
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Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer.
Nat Commun. 2018 Aug 27;9(1):3473.
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Guided self-organization and cortical plate formation in human brain organoids.
Nat Biotechnol. 2017 Jul;35(7):659-666.
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Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
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Science. 2018 Jan 5;359(6371):91-97.
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HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
Nat Commun. 2017 Jul 21;8(1):93.
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Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
J Biol Chem. 2017 Oct 20;292(42):17216-17224.
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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.
Nature. 2018 Mar 29;555(7698):673-677
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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide.
Mol Cell. 2017 Jul 6;67(1):71-83.e7.
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Histidine catabolism is a major determinant of methotrexate sensitivity.
Nature. 2018 Jul;559(7715):632-636.
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IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.
Cell. 2018 Jan 11;172(1-2):218-233.e17.
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IL-23 secreted by myeloid cells drives castration-resistant prostate cancer.
Nature. 2018 Jul;559(7714):363-369.
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Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.
J Cell Biol. 2017 Aug 7. pii: jcb.201612148.
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Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
EMBO J. 2017 Oct 10. pii: e201796797.
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Induction of innate immune memory via microRNA targeting of chromatin remodelling factors.
Nature. 2018 Jul;559(7712):114-119.
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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.
Mol Metab. 2018 Mar;9:141-155
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Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice.
Mucosal Immunol. 2018 Jan 24.
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Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration.
Cell Rep. 2017 Aug 1;20(5):1050-1060.
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Lactate dehydrogenase activity drives hair follicle stem cell activation.
Nat Cell Biol. 2017 Sep;19(9):1017-1026.
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LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
Nature. 2017 Mar 30;543(7647):681-686.
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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.
Nature. 2017 Jul 13;547(7662):236-240.
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Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.
ACS Nano. 2017 Sep 26;11(9):9223-9230.
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Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis.
Nat Commun. 2018; 9: 2986.
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Long-Term High-Resolution Imaging of Developing C. elegans Larvae with Microfluidics.
Dev Cell. 2017 Jan 23;40(2):202-214.
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Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota.
Diabetologia. 2018 Mar 3.
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Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.
J Cell Biol. 2018 Jan 2;217(1):195-209
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance.
Cell Metab. 2018 Apr 3;27(4):828-842.e7.
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Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling.
Nat Commun. 2018 Jan 17;9(1):257.
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Metabolic Induction of Trained Immunity through the Mevalonate Pathway.
Cell. 2018 Jan 11;172(1-2):135-146.e9.
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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.
Nat Cell Biol. 2017 Sep;19(9):1116-1129.
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Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Nature. 2017 Jul 31.
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MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer Cell. 2017 Jun 12;31(6):755-770.e6.
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature. 2017 Oct 26;550(7677):481-486.
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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
Cell. 2017 Oct 19;171(3):642-654.e12.
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mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
Mol Cell. 2017 Oct 19;68(2):323-335.e6.
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Mol Cell. 2017 Jul 6;67(1):128-138.e7.
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Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Neuron. 2017 Apr 5;94(1):93-107.e6.
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Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Cell. 2017 Nov 30;171(6):1301-1315.e14.
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Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma.
ACS Nano. 2018 Feb 27;12(2):1250-1261.
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Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction.
Nat Cell Biol. 2018 Mar;20(3):262-271.
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Near-infrared remotely triggered drug-release strategies for cancer treatment.
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12419-12424.
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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.
Nat Commun. 2018 Jan 18;9(1):291.
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