生化所106-2專題討論
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A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.
Cell. 2016 Nov 17;167(5):1339-1353.e21.
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A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Nat Biotechnol. 2018 Mar;36(3):258-264.
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A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Mol Cell. 2017 Jan 19;65(2):347-360.
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A molecular signature for anastasis, recovery from the brink of apoptotic cell death. J Cell Biol. 2017 Aug 2. pii: jcb.201706134.106-1
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A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Nat Cell Biol. 2017 Sep;19(9):1105-1115.
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A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Nat Cell Biol. 2017 Sep;19(9):1105-1115.
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A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease.
J Am Chem Soc. 2017 Oct 18;139(41):14783-14791.
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A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Nat Cell Biol. 2017 Oct;19(10):1260-1273.
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Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria.
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1895-1900.
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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Cell Metab. 2017 Sep 5;26(3):576.
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Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.
Cell Metab. 2016 Aug 9;24(2):311-23.
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12
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
Neuron. 2016 Jul 6;91(1):41-55.
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Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.
Nat Commun. 2017 Jul 24;8:16013.
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Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.
Cell Metab. 2017 Feb 7;25(2):448-462.
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AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.
EMBO J. 2017 Apr 13;36(8):995-1010.
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.
Nature. 2017 Dec 14;552(7684):194-199.
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17
An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.
Structure. 2017 Jul 5;25(7):967-977.e5.
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An ID2-dependent mechanism for VHL inactivation in cancer.
Nature. 2016 Jan 14;529(7585):172-7.
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19
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.
Science. 2017 May 5;356(6337):513-519.
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Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth.
ACS Chem Biol. 2017 Aug 18;12(8):2085-2096.
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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.
Nat Nanotechnol. 2017 Sep;12(9):877-882.
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Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.
Mol Cell. 2017 Jul 6;67(1):55-70.e4.
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Autophagy maintains the metabolism and function of young and old stem cells.
Nature. 2017 Mar 9;543(7644):205-210.
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Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.
Cell Host Microbe. 2018 Jan 10;23(1):27-40.e7.
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Bioengineering Bacterially Derived Immunomodulants: A Therapeutic Approach to Inflammatory Bowel Disease.
ACS Nano. 2017 Sep 5.
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Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.
Mol Cell. 2017 Aug 3;67(3):433-446.e4.
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Mol Cell. 2017 May 18;66(4):517-532.e9.
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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
Science. 2016 Aug 5;353(6299):aaf5573.
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C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation.
Nat Commun. 2018 Jan 4;9(1):51.
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Caloric Restriction Promotes Structural and Metabolic Changes in the Skin.
Cell Rep. 2017 Sep 12;20(11):2678-2692.
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Carbohydrate-Neuroactive Hybrid Strategy for Metabolic Glycan Engineering of the Central Nervous System in Vivo.
J Am Chem Soc. 2017 Jan 18;139(2):693-700.
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CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Deliver Toxins to B-Lymphoma Cells.
J Am Chem Soc. 2017 Sep 13;139(36):12450-12458.
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Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules.
Nat Nanotechnol. 2017 Aug 21.
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34
Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.
Dev Cell. 2017 Feb 6;40(3):313-322.e5.
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Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.
Mol Cell. 2016 Oct 20;64(2):347-361.
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Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics.
Mol Cell. 2017 Nov 16;68(4):758-772.e4.
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Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.
Cell Metab. 2017 Mar 7;25(3):622-634.
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CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity.
Cell Metab. 2017 Jul 5;26(1):243-255.e6.
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Development of DNA Nanostructures for High-Affinity Binding to Human Serum Albumin.
J Am Chem Soc. 2017 May 31;139(21):7355-7362.
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat Chem Biol. 2017 Jun;13(6):624-632.
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Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Cancer Cell. 2017 Apr 10;31(4):516-531.e10.
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Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism.
J Am Chem Soc. 2017 Mar 8;139(9):3465-3472.
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
Cell Metab. 2017 May 2;25(5):1135-1146.e7.
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Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nat Biotechnol. 2016 Nov;34(11):1161-1167.
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Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.
Nat Commun. 2017 Feb 15;8:14228.
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Dynein Binding of Competitive Regulators Dynactin and NudE Involves Novel Interplay Between Phosphorylation Site and Disordered Spliced Linkers.
Structure. 2017 Jan 31.
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Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.
Cancer Cell. 2017 Feb 13;31(2):256-269.
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EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
EMBO J. 2015 Dec 2;34(23):2953-70.
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Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy.
Nat Nanotechnol. 2017 Jul 17.
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Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide.
Oncogene. 2018 Feb 20.
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Cell. 2017 Aug 24;170(5):875-888.e20.
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Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7260-E7267.
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EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.
Nature. 2017 Feb 16;542(7641):357-361.
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Evolution of a designed protein assembly encapsulating its own RNA genome.
Nature. 2017 Dec 21;552(7685):415-420.
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Extreme disorder in an ultrahigh-affinity protein complex.
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Nature. 2018 Mar 1;555(7694):61-66.
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Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Nature. 2016 Nov 10;539(7628):294-298.
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Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis.
J Am Chem Soc. 2015 Aug 5;137(30):9685-93.
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Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1698-E1706.
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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Cell Metab. 2017 Oct 3;26(4):693.
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Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5592-7.
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GRID-seq reveals the global RNA-chromatin interactome.
Nat Biotechnol. 2017 Sep 18.
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Guided self-organization and cortical plate formation in human brain organoids.
Nat Biotechnol. 2017 Jul;35(7):659-666.
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Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
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Science. 2018 Jan 5;359(6371):91-97.
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HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
Nat Commun. 2017 Jul 21;8(1):93.
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Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
J Biol Chem. 2017 Oct 20;292(42):17216-17224.
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Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors.
J Hepatol. 2016 Dec;65(6):1188-1197.
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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide.
Mol Cell. 2017 Jul 6;67(1):71-83.e7.
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High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.
Cell Metab. 2017 Jan 10;25(1):197-207.
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Histone Degradation in Response to DNA Damage Enhances Chromatin Dynamics and Recombination Rates.
Nat Struct Mol Biol 24 (2), 99-107. 2017 Jan 09.
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IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.
Cell. 2018 Jan 11;172(1-2):218-233.e17.
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Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.
J Cell Biol. 2017 Aug 7. pii: jcb.201612148.
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In vivo formation of vacuolated multi-phase compartments lacking membranes.
Cell Rep. 2016 Aug 2; 16(5): 1228–1236.
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Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
EMBO J. 2017 Oct 10. pii: e201796797.
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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.
Mol Metab. 2018 Mar;9:141-155
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Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Cell. 2016 Jan 14;164(1-2):128-40.
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Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction.
PLoS Genet. 2016 Jul 14;12(7):e1006135.
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Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice.
Mucosal Immunol. 2018 Jan 24.
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Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration.
Cell Rep. 2017 Aug 1;20(5):1050-1060.
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Lactate dehydrogenase activity drives hair follicle stem cell activation.
Nat Cell Biol. 2017 Sep;19(9):1017-1026.
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LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
Nature. 2017 Mar 30;543(7647):681-686.
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LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.
Structure. 2016 Jul 6;24(7):1130-41.
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LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.
Nat Cell Biol. 2017 Jan;19(1):60-67.
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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.
Nature. 2017 Jul 13;547(7662):236-240.
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Local regulation of gene expression by lncRNA promoters, transcription and splicing.
Nature. 2016 Nov 17;539(7629):452-455.
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Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.
ACS Nano. 2017 Sep 26;11(9):9223-9230.
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Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota.
Diabetologia. 2018 Mar 3.
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Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.
J Cell Biol. 2018 Jan 2;217(1):195-209
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Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.
Nat Cell Biol. 2017 Sep;19(9):1116-1129.
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Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Nature. 2017 Jul 31.
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MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer Cell. 2017 Jun 12;31(6):755-770.e6.
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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature. 2017 Oct 26;550(7677):481-486.
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Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis.
Sci Rep. 2016; 6: 29038.
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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
Cell. 2017 Oct 19;171(3):642-654.e12.
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mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.
Nature. 2017 Jan 12;541(7636):228-232.
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mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
Mol Cell. 2017 Oct 19;68(2):323-335.e6.
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Mol Cell. 2017 Jul 6;67(1):128-138.e7.
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Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Neuron. 2017 Apr 5;94(1):93-107.e6.
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Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Cell. 2017 Nov 30;171(6):1301-1315.e14.
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Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction.
Nat Cell Biol. 2018 Mar;20(3):262-271.
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Nanoscale architecture of cadherin-based cell adhesions.
Nat Cell Biol. 2017 Jan;19(1):28-37.
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