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Asker NameQuestionAnswer(s)
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Dr. Malak Abed AlThagafiAuthors in Nature paper and arising matters are same?live answered
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Julian WillettWas there a causal relationship with hemoglobin in addition to RBC?We do not include hemoglobin in this analysisUnderstood, thank you
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Emma Duncanare you able to parse T1Dm vs. T2DM?live answered
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Jenny HuffmanAre there any plans to make "leave one out" analyses available again for R6?live answered* leave one out by cohortThank you!!
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Renato PolimantiHow is the liability-scale heritabilities of the COVID-19 phenotypes in R6?These were observed heritability, which is what was also reported in R5
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Minoli PereraWAs the RBC measure taken at the time of infection?some groups may have taken these - but we have not collected any phenotypic information of this nature centrally
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Val PrisecaruFrom what I remember, variants in the HBB gene gave a protective effect. Would Thalassemia variants now be considered even more important, in light of the fact that they start out with significantly lower hemoglobin levels?
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Emma DuncanTo extend question from julian Hb vs. red blood cell count are not synonymous and relationship with CAL/COAD and smoking
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Andres MorenoIs the plan to update the paper with each data freeze?live answered
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Tim Behrenslooked like there may be weak associations of lupus, ms, ra (i.e. autoimmune disease) with susceptibility. which direction?Lupus - protective; MS - risk; RA - protective; but no significant assocations after multiple testing etc.thanks! appreciate
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Antonella RivaHi! Would You be eventually interested in pediatric patients with long-covid symptoms?live answered
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Ricardo Alejandro Verdugo SalgadoWhat is the minimun sample size for a study to participate in the Long Covid initiative?live answered
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Robin WaltersFor the recessive option did you include compound heterozygotes (at the given mask)?live answered
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Jamal Nasirseems like rare variants are going to be rea;;y hard to find. And if you have one or two of them yhrry wony be statistica;;y significant. Guillaumr?Yes, incredibly difficult to find. I skipped the statistical adjustments that were made in order to account for this, but it's all explained in the protocol here: https://docs.google.com/document/d/1QrwktjejSH7A1Srzdkyfg4gJi8u4HAFrXPn8XrdX7wo/edit?usp=sharing
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Jamal Nasirsorry was typing in the dark. If you have just one or two allele counts it will be hard to proove statistical sig?Agree, I've answered in the previous question.
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Marta AlarconComment: In SLE, the risk in men is increased because many appear to have Klinefelter´s syndrome which is believed to “duplicate” TLR7 and the possibility to develop SLE.yes. ineed overexpression of TLR7 is also dangerous. This gene excapes X-inactivation and mutations in heterozygous females are extracted as protectve feature in female sex (a sort of balanced polymorphism)
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David van Heelwe have Y chr (GSA chip). do you have Ola's email pleaseole.bernt.lenning@randaberg.kommune.nothanks. have emailed you
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