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Carbamazepine
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PLEASE INSERT THE YELLOW TEXT
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THERAPEUTIC RANGE : 4 -12 mg/L
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Usual dosageAdults :
5 - 10 mg/kg/day
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Patient's details5.19
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Dose 100mg every 12hours (T)
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Weight 41kg
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Constant 0.064L/kg/Hr
Monotherapy = 0.064 , Polytherapy = 0.1
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CLpopulation2.624L/hr
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Cpss measured3.75mg/L
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Cdesired7mg/L12intended frequency (Tnew)#NAME?
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 mn
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1. To predict Cpss based on population clearance:
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Cpss ave2.54mg/LS X F X Dose
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T X Clpopulation
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2. To determine NEW DOSE
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Patient's Clearance, CLpt1.78S X F X Dose
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T X Cpss measured
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New Dose186.67CLpt x C desired x Tnew
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S X F
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3. To determine Cpss expected if NEW DOSE is suggested
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Dosesuggested200.0mg
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Tnew12.0hr
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Cpss desired7.5mg/LDosesuggested X S X F
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CLpt X Tnew
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Carbamazepine
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Adults
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Usual dosageanticonvulsant 5 - 10 mg/kg/d
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Usual dosing intervalbd,tds,qid depending pt tolerance
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t ½ 6 - 25 H (chronic dosing)
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Formula :
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Salt factor, S = 1.0
Bioavailability, F = 0.8
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Clearance L/H = 0.064 x BW (kg) [monotherapy]
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 0.1 x BW (kg) [polytherapy]
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t ½ H = 15 [monotherapy]
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 10 [polytherapy]
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MD mg = Ctarget x CL x T
T = dosing interval
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