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aSolvingMS.org Regenerative Trials Database Click Links for Enrollment Info Proposed ModalityCountryMS Type For TrialEBV RxTrial PhasePhase StatusYears Until ApprovalFDA Approval (est.)Pipeline Also in Trial For Phase Score Most Weight Effective- nessFDA Acceler- ation Overall Score = Phase Score^2 xEffectiveness +AccelerationStart date27 PPMS 15 SPMS 23 RRMS 12 ALL TYPES
https://www.facebook.com/groups/solvingms/
http://bit.ly/SolvingMS_Database
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SolvingMS.org MS Research Database
Curative & Regenerative Clinical Trials
As of:2/11/2025Overall Score
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Trial Finder
Enroll in Recruiting Trials!
Copyright © 2025 Solving MS - All Rights Reserved
Ph 3=10Ph 2=39Ph 1=19
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PPMS 16 SPMS 15 RRMS 23
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Policy and Research Papers
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Accelerate Regenerative Medicine Act (ARMA) by Solving MSWhitepaper: Legislation to Address the National Emergency of Infection-Associated Chronic Conditions & Autoimmune Disease.
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Antivirals & Other Treatments for EBV in MSHistory of research on EBV as the cause of MS and conclusive proof published Jan. 2022. Includes clinical trials of antivirals and other approaches for EBV. Also see Should I Get an EBV Test If I Have MS?
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Paxlovid: Epstein-Barr Virus Antiviral Effect?Patient Reported Outcomes of Paxlovid benefits for: Long Covid, MS, ME/CFS and primary EBV.
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Gregory-MS AI Search Engine for all MS papers and clinical trialsStart with the Observatory to see all MS therapy research over time.
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Collaborate with SolvingMS!Join our Research Study Group! 1.6k members tracking the research! All disease types welcome. See Pipeline column. We can win this battle faster together.
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MS Clinical Trials
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1Sanofi, BTKi TolebrutinibRemyelination Slow-disability EBV-AntiviralManynrSPTreat3Recruiting12026MS 32.5Break- through Therapy 326
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2Immunic, IMU-838 Vidofludimus_Calcium↓ Microglial Astrocyte Neuroprotective Anti-inflammatory EBV-AntiviralManyRR ENSURE-1 ENSURE-2Treat3Recruiting12026MS UC CD32.7525
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3Sanofi, Frexalimab Trial InfoRemyelination Immune-tolerance Slow-disabilityUSA QUEBEC SPTreat3Recruiting22027MS 32.7525
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4Sanofi, Frexalimab Trial InfoRemyelination Immune-tolerance Slow-disabilityUSA QUEBEC RRTreat3Recruiting22027MS 32.75252023-12-272026-12-232028-03-24
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5BTKi FenebrutinibRemyelination Slow-disability EBV-AntiviralManyRR PPTreat3Active, Not Recruiting1.52026.5MS 32.5232023-12-132027-05-062027-05-06
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6FIRMS EBV - Spironolactone vs Tenofovir Alafenamide Info TrialEBV Antiviral AustrailiaRRTreat3Not yet recruiting Planned 202532028MS 32.523
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7Griffith University, Spironolactone & Famciclovir for EBV Info STOP-MS TrialEBV Antiviral Australia All StatesSP PPTreat3Not yet recruiting Planned 202532028MS32.523
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8Novartis, BTKi Remibrutinib TrialsRemyelination Slow-disabilityManyRRTreat3Recruiting22027MS 32.523
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10Clemastine for Remyelinating Internuclear Ophthalmoparesis in MSRemyelinationAmsterdamALL3Recruiting or Off-label precription22027MS3218802022-08-302024-052026-11
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11Octopus MS: Metformin, Clemastine, Alpha Lipoic Acid TrialRemyelinationUKSP PP3Recruiting or Off-label precription32028MS3218
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12Nervgen, NVG-291 Axonal regeneration Neurogenesis Remyelination NeuroplasticityUSARR2SCI Q2 2025 5.52030.5SCI MS AD ALS STROKE23Priority Review315
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13Immunic, IMU-838 Vidofludimus_CalciumAnti-inflammatory immunomodulator Neuroprotective AntiviralManySP PP CALLIPER Treat2Recruiting42029MS UC 2.752.7521
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14Clene, CNM-Au8 Nanogold Remyelination Neuroregenerative Mitochondria repairUSARR2Completed32028MS ALS PD2.752.7521
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15Tisch MS Center, Stem Cells Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSASP PP2Completed Published32028MS2.752.5Priority Review322
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16Hope Biosciences, Stem Cells Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSARR2Completed 2024 Publication Pending32028MS C19 LCoviD SCI PD...2.752.519
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17Brainstorm, NurOwn Stem Cells Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSASP PP2Completed Published32028MS ALS2.752.5192023-06-01
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18Hadassah, Stem Cells Video Info Trial Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingIsraelSP PP2Ph 2 Published Ph 3 Planned32028MS2.752.519
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19Clene, CNM-Au8 Nanogold Remyelination Neuroregenerative Mitochondria repairUSASP PP2Active, Not Recruiting42029MS ALS PD2.52.7517
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20 Imcyse, Imotopes Info TrialMBP-tolerizing MoldovaRRTreat1/2Active, Not Recruiting42029MS24161502022-04-122025-05-232025-12-31
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21Tiziana, Foralumab Info Trial↓ Microglial Activity T-cell balance Neuroprotective Anti-inflammatoryUSASP2Recruiting32028MS AD ALS Crohn's C-1922.75Fast Track213542023-11-152024-112024-11
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22Diaprotectome (DITPA)Remyelination Neuroregenerative Mitochondria repairGreece AustraliaSP PP2Planned 20255.52030.5MS 22.75114002025
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22SMART-MS Stem Cells Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingNorwaySP PP2Active, Not Recruiting3.52028.5MS22.510182021
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24The TAF-MS study: Tenofovir alafenamide fumarate (TAF) for EBV in MS – a proof of concept studyEBV Antiviral NorwayRRTreatPilotAnnounced 202432028MS22.510
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25Biogen, BTKi BIIB091 Trial InfoRemyelination Slow-disability EBV-AntiviralUSARR2Recruiting42029MS22.5102702023-07-252025-07-102026-11-09
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26Metformin & AMPK - 7 TrialsRemyelinationManyRR2Recruiting or Off-label precription32028MS LCovid ME/CFS228362020-09-222027-02-222027-05-31
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26UCSF, NAC (N-Acetyl Cysteine) Glucose regulation Anti-inflammatory MitochondriaUSARR2Recruiting3Avilable Now OTCMS21.56982022-02-162026-022026-02
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27Alpha Lipoic Acid InfoNeuroprotective Slows brain atrophyUSASP2Completed Published 2017.3Avilable Now OTCMS21.56
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28TUDCA Bile acid supplement Info.Neuroprotective Anti-inflammatory USASP1/2Completed Published 2024.5.5Avilable Now OTCMS21.562018-06-192022-04-282022-07-05
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29AndrographisRemyelinationRR2Completed Published3Avilable Now OTCMS228362020-09-222027-02-222027-05-31
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31GeNeuro, Temelimab Neuroregenerative Immunomodulator ManyTreat2Completed Published42029MS ALS LCovid228
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32Harvard, Antivirals for EBV in MSEBV Antiviral USA HarvardRRTreatPilotRecruiting by Invitation42029MS22.510
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33Haukeland Univ. Stem Cells TrialNeuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingNorwaySP2Recruiting42029MS22.5102021-08-092024-10-042025-01-04
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34Umbilical Cord Stem Cells IV & Intrathecal (UMSC01) TrialNeuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingTaiwanRR1/2Recruiting42029MS22.5104109/08/202312/31/20262026-12-31
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35Duke Univ, Stem Cells TrialNeuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSAPP1Recruiting5.22030.2MS22.510202021-01-242025-08-302025-08-30
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36Extracorporeal Photopheresis (ECP) Info1 Info2 Trial. Neuroregenerative Anti-inflammatory Immunomodulator UAESP1/2Active, Not Recruiting3.52028.5MS22.510152022-03-262025-032025-06
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37Oculis, OCS-05 Info Trial Neuroregenerative Anti-inflammatoryFranceOptic Neuritis2aRecruiting52030MS ON PD Glaucoma Epilepsy22Orphan drug designation192022-12-192025-08-272024-09-16
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38MBP Tolerizing Vaccine * Trial MBP-tolerizingSpainALLTreat2Recruiting52030MS228
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39Denali/Sanofi, SAR443820 Info Trial ManyRR SP2Recruiting52030MS228
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40Contineum, PIPE-307 Muscarinic M1 Antagonist VISTA Trial InfoRemyelinationUSARR2Active, Not Recruiting32028PMS2282023-11-062025-082025-09
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41Ifenprodil TrialRemyelinationFranceRR2No Yet Recruiting52030MS228602024-03-012027-03-012027-06-01
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42Low Dose Naltrexone Trial Info on LDN & Prescribers Anti-inflammatoryManyALL2Recruiting or Off-label precription32028MS LCovid ME/CFS21.56
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43MediciNova, Ibudilast MN-166 Neuroprotective Anti-inflammatory Slow-brain-atrophyUSASP PP2Completed Published. 2018 2024.32028MS 21.56
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44Hydroxychloroquine HCQ↓ Microglial Activity Delays progressionCanadaPP2Off-label Published 2022 2023.42029MS RA21.56
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45RapamycinInhibits mTOR Less plaques, Improve EDSS, T-Cell reg Anti-inflammatoryUSARRTreatPilotCompleted Published 2018MS LCovid ME/CFS2018-06-192022-04-282022-07-0559
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46Spinal Cord Neuromodulator (SCONE™) for Neurogenic Bladder Info TrialSpinal cord neuromodulationUSA Canada IndiaALL2Recruiting32028MS SCI Stroke21.5Breakthrough Device17
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47TAURUS2 Magnetic Stim Myelin Info TrialRemyelinationAustraliaALL2Recruiting32028MS2281082024-11-222024-08-2024
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48Transcranial Magnetic Stimulation There are 10 trials .ALLRecruitingAvilable Now
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49Acute Intermittent Hypoxia TrialNeuroplasticity Motor FunctionRR2Completed Published 2024.32028MS21.5trial
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50Kyverna, KYV-101 CAR-T Cell Trial InfoB cell depletorUSA StanfordSP PPTreat2Recruiting52030MS Lupus23Break- through Therapy 113
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51Btristol Myers, CC-97540 CAR-T Cell Info TrialB cell depletorTreat52030MS2312
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52New Gadolinium-Free MRI Contrast Agent - RVP-001A safey trial to test an alternative to gadolinium-based contrast agentUSA CT MAAll2Recruiting2
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53Iaso, Eque-cel CAR-T Info TrialB cell depletorChinaSP PPTreat1Recruiting62031MS133362020-09-222027-02-22
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54Anokion, ANK-700 Inverse Vaccine Trial Results Immune-tolerance USARRTreat1Completed Published.52030MS CD T1D1.52.56
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55FibroBiologics, CYMS101 Info Trial RemyelinationUSARR1Completed52030MS DDD DWC SLE1.52.56
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56FSD Pharma, Lucid-MS Info Trial RemyelinationCanadaRR1Completed 03/2024.52030MS1.525
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57Synaptogenix, Bryostatin-1 Info TrialAxonal regeneration Remyelination Synaptogenesis Prevent nerve death Anti-inflammatoryUSA OhioALL1Recruiting62031MS AD Autism Fragile-X133202024-06-262026-04-012026-08-01
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58Allogenic Adipose MSC Stem Cells Intrathecal for PPMS (MAESTRO-4MS) TrialNeuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingFrance1Not Yet Recruiting Start Q4 202452030MS12.53102024-10-012028-06-012028-12-01
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59ImStem, Stem Cells Info Trial Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSA GeorgiaRR SP1Active, Not Recruiting52030MS12.532021-08-312027-04-012027-04-01
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60Neural Stem Cells Brain Injections Info1 Info2 Trial.Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSA CO ItalySP1Completed Published 202352030MS12.53152017-09-092021-05-292021-05-29
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61Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration MS & ALS (CONTRASTOME) Trial Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingItalyALL MS & ALSPilotPlanned 4th Qtr 202472032MS ALS12.53602024-09-012026-03-312026-09-30
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62Ixazomib SIZOMUS Trial InfoImmunomodulatorUK LondonALL1Active, Not Recruiting52030MS Cancer122722020-08-202020-08-202023-08-20
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63Indapta, IDP-023 (natural killer cells) + Ocrevus InfoAntiviralSP PPTreat1Planned Q4 202462031MS Cancer122
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64Lapix, LPX-TI641 Info TrialIimmune-tolerance USA, JordanALL1Completed Nov 202452030MS NMOSD MOGAD1222023-10-302024-04-152024-08-01
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65Moderna EBV Vaccine • 1195 Treat • 1189 Prevent InfoAntiviralUSAALLTreat Prevent1Completed52030MS1222022-04-012025-12-31
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66NIH, EBV MS Vaccine * Info TrialAntiviralUSASP PPPrevent1Recruiting62031MS122
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ModeX, MDX2201 EBV Vaccine Info Trial AntiviralUSASP PPPrevent1Recruiting62031MS122
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67USCF, Bazedoxifene Info TrialRemyelinationUSA CA RR1a/2bRecruiting 42029MS122
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69Contineum, PIPE-791 LPA1R Antagonist Trial InfoRemyelinationUSAHealthy volunteer1Recruiting62031PMS IPF122
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70Investigating the effect of Cerebral Venous Vasculature on Venous Pressure in Multiple Sclerosis InfoNeurovascularAsutraliaSP1Pending funding72030MS CD T1D122
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71UTI: Phage Therapy, UTI Vaccines, Antibiotics (Orlynvah)UTIs are a leading cause of death for PwMS. New antibiotic approved 12/12/2024ManyAll Recruiting Completed ApprovedVaries802022-08-302024-052026-11
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Pasithea, PAS-002 MS Vaccine - Info
AntiviralUSAALLTreat0Pending82033NF1 ALS MS 0.52Breakthrough Therapy 12
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73Simvastatin Trial 2 (MS-STAT2) Info Trial Neuroprotective Neuroregenerative Anti-inflammatory Slow-brain-atrophyUKSP3Did not meet endpoints 20241MS32189642018-03-282024-08-312024-08-31
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74Biogen, BTKI Orelabrutinib * TrialsManyRRTreat2Partial Hold Dec 2022 then Cancelled 5MS2.52.5162019-12-192024-06-01
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75Famciclovir for EBV in MS * TrialAntiviralUKALLTreat2Completed Report4MS200
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Merck, BTKi Evobrutinib Info Trials
ManyRRTreat3Did not meet endpoints Dec 20232MS32.523
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77UCSF, Clemastine Info TrialUSARR203/2024 Halted Adverse Event4MS21.56
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78Atara, ATA188USASP PPTreat2Terminated5MS2.753Breakthrough Therapy 124
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Best viewed on a screen larger than a mobile phone.
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Scroll down for colmn heading explanations.
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Tap Trial Name link for a Research Profile page, or use Info and Trial links.
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Before you discuss a trial with your doctor, contact the trial coordinator to see if you meet inclusion/exclusion criteria.
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Click All Therapies tab at bottom of screen for all 130+ therapies in the database.
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Click HERE to join the Solving MS research study group. Members are discussing and joining these trials!
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