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SolvingMS.org Regenerative Trials Database Click Links for Enrollment Info Proposed ModalityCountryMS Type For TrialEBV RxTrial PhasePhase StatusYears Until ApprovalFDA Approval (est.)Pipeline Also in Trial For Phase Score Most Weight Effective- nessFDA Acceler- ation Overall Score = Phase Score^2 xEffectiveness +AccelerationStart dateTrial Readout Estimate
https://www.facebook.com/groups/solvingms/
http://bit.ly/SolvingMS_Database
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SolvingMS.org MS Research Database
Curative & Regenerative Clinical Trials
As of:9/14/2026Total=92Overall Score
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Trial Finder
Enroll in Recruiting Trials!
Copyright © 2026 Solving MS - All Rights Reserved
Ph 3=14Ph 2=44Ph 1=34
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# of trials: PPMS 32 SPMS 38 RRMS 30 ALL MS Types 17
https://clinicaltrials.gov/study/NCT05201638
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Special Reports and Resources
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Accelerate Regenerative Medicine Agenda (ARMA) by Solving MSWhitepaper: Agenda to Address the National Emergency of Infection-Associated Chronic Conditions & Autoimmune Disease.
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2026 Antiviral Trials for EBV in MSThree phase 3 clinical trials are starting in 2025 to test the repurposed drugs Spironolactone, Tenofovir Alafenamide and Famciclovir for antiviral effect against Epstein-Barr virus (EBV) in MS.
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History of Antivirals & Other Treatments for EBV in MSHistory of research on EBV as the cause of MS and conclusive proof published Jan. 2022. Includes clinical trials of antivirals and other approaches for EBV. Also see Should I Get an EBV Test If I Have MS?
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Paxlovid: Epstein-Barr Virus Antiviral Effect?Patient Reported Outcomes: Paxlovid cor Covid-19 also improved symptoms for Long Covid, MS, ME/CFS and primary EBV. Did Paxlovid reduce EBV?
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Supplements for Mitochondria and MyelinAn Evidence-Based Analysis of Nutritional, Lifestyle, and Cellular Interventions To Improve Mitochondrial Function and Support Myelin in MS.
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Brain-Regeneration for MS AI Search Engine for all MS research studies and clinical trials.
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Collaborate with SolvingMS!Join our Research Study Group! Over 2000 members tracking the research! All disease types welcome. See Pipeline column below - many theraoies treat multiple diseases. We can win this battle faster together!
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MS Clinical Trials
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1Sanofi, BTKi Tolebrutinib↓ Microglia Slow disability Modulate B-cells EBV-AntiviralManynrSPTreat3FDA refused approval Jan 20260.752026.75MS 32.5Break- through Therapy 32611312020-09-242024-08-292024-08-29
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2Immunic, IMU-838 Vidofludimus_Calcium↓ Microglia Astrocyte Stop progression Anti-inflammatory EBV-↓Pyrimidine ManyRR ENSURE-1 ENSURE-2Treat3Recruiting22028MS UC CD32.752510502021-11-182024-092024-092032-09
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3AB Sciences, Tyrosine Kinase inhibitor TKi Masitinib (MAXIMS) Trial Info May2025 ↓Microglia ↓Mast cells Slow progression FrancenaSP PP3Recruiting22028MS ALS AD C19 Asthma32.75258002022-06-282025-12
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4BTKi Fenebrutinib↓ Microglia Stop disability Modulate B-cells EBV-AntiviralManyRR PPTreat3Active, Not Recruiting22028MS 32.75252023-12-132027-05-062027-05-06
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5Sanofi, Frexalimab FREVIVA Trial Info 2026Remyelination Immune-tolerance Slow-disabilityUSA QUEBEC nrSPTreat3Active, Not Recruiting32029MS 32.75252023-12-272028-03-242028-03-24
Late 2028 or early 2029
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6Sanofi, Frexalimab FREXALT Trial Info 2026Remyelination Immune-tolerance Slow-disabilityUSA QUEBEC RRTreat3Active, Not Recruiting2.52028.5MS 32.75252023-12-272027-05-062027-05-06
Late 2027 or early 2028
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7Sanofi, Frexalimab Subcutaneous FREXCITE Trial Info 2026Remyelination Immune-tolerance Slow-disabilityManyRR nrSPTreat3Recruiting 12 month trial32029MS 32.75251602026-01-142027-07-152028-11-30Mid 2029
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8FIRMS EBV - Spironolactone vs Tenofovir Alafenamide Info & TrialsEBV Antiviral AustrailiaRRTreat3Not yet recruiting Planned 202532029MS 32.7525
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8Griffith University, Spironolactone & Famciclovir for EBV Info & TrialsEBV Antiviral Australia All StatesSP PPTreat3Recruiting32028MS32.7525
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9Novartis, Remibrutinib BTKi Info 5 Trials↓Mast cells Slow progression EBV-AntiviralManyRR PPTreat3Recruiting32029MS CSU MG Sjögren's32.75258002021-12-132026-04-302030-10-30
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10TKI MastinibRemyelination Slow-disabilityEuropeSP PP3Active, Not Recruiting22028MS 32.5238002022-06-282028-122028-12
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11Clemastine for Remyelinating Internuclear Ophthalmoparesis in MSRemyelinationAmsterdamALL3Recruiting or Off-label precription2.52028.5MS3218802022-08-302024-52026-11
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12Octopus MS: Metformin, Clemastine, Alpha Lipoic Acid TrialRemyelinationUKSP PP3Recruiting or Off-label precription32029MS3218
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13Nervgen, NVG-291 Axonal regeneration Neurogenesis Remyelination NeuroplasticityUSASCI3SCI Q2 202562032SCI MS AD ALS STROKE23Fast Track 315402023-08-082026-032026-04
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Sanofi, Frexalimab Trial Info 2024Remyelination Immune-tolerance Slow-disabilityManyRRTreat2Completed Published 202432029MS 32.7525
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14Immunic, IMU-838 Vidofludimus_CalciumAnti-inflammatory immunomodulator Neuroprotective EBV-↓Pyrimidine ManySP PP CALLIPER Treat2Active, Not Recruiting42030MS UC 2.752.75214502021-09-302025-01-072025-01-07
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15Clene, CNM-Au8 Nanogold Remyelination Neuroregenerative Mitochondria repairUSARR2Completed32029MS ALS PD2.752.7521
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16Tisch MS Center, Stem Cells Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSASP PP2Completed Published3.52029.5MS2.752.5Fast Track322
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17Hope Biosciences, Stem Cells Neuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingUSARR2Completed 2024 Topline Results32029MS C19 LCoviD SCI PD...2.752.5RMAT423
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18Brainstorm, NurOwn Stem Cells Neuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingUSASP PP2Completed Published3.52029.5MS ALS2.752.5Priority Review1202023-06-01
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19Hadassah, Stem Cells Video Info Trial Neuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingIsraelSP PP2Ph 2 Published Ph 3 Planned3.52029.5MS2.752.519
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20Clene, CNM-Au8 Nanogold Non-immunomodulatory Remyelination Neuroregenerative Mitochondria repairUSASP PP2Active, Not Recruiting32029MS ALS PD2.52.7517
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20 Imcyse, Imotopes Info TrialMBP-tolerizing MoldovaRRTreat1/2Unknown Status42030MS24Priority Review1171502022-04-122025-05-232025-12-31
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Tiziana, Foralumab Info 5/25 Trial
↓Microglial Activity ↑T-cell balance→ ↓Glial Inflammation USASP2Recruiting32029MS MSA ALS AD LC T1DM SCI22.75Fast Track314542023-11-152025-112025-11
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22NeuOrphan, Diaprotectome (DITPA)Remyelination Neuroregenerative Mitochondria repairGreece AustraliaSP PP2Planned Q3 20255.52031.5MS 22.75114002025
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23SMART-MS Stem Cells Neuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingNorwaySP PP2Active, Not Recruiting3.52029.5MS22.510182021
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24TestOsterone TreatmEnt on Neuroprotection and Myelin Repair in RRMS (TOTEM-RRMS) TrialRemyelination Neuroregenerative FranceRR2Recruiting42030MS228402019-10-292027-12-012027-12-01
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25Biogen, BTKi BIIB091 Trial InfoModulate B-cells Slow progression EBV-AntiviralUSARR2Completed 42030MS22.5102702023-07-252025-07-102026-11-09
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26Metformin & AMPK - 7 TrialsRemyelinationManyRR2Recruiting or Off-label precription32029MS LCovid ME/CFS22Fast Track311362020-09-222027-02-222027-05-31
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27Combination Therapies: Pioglitazone, Clemastine, Dantrolene, Pirfenidone (TRAP-MS) TrialCombination therapies to target pathogenic processes in MS.USA MDSP PP2Recruiting42030MS21.562502017-08-112026-01-012029-01-01
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28Clemastine Fumarate as a Myelin Repair Therapy (ReVIVE) TrialRemyelinationUSA UCSFRR1/2Recruiting42030MS21.56742023-08-012025-06-012025-06-01
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29BALANCE-MSS-1 for Spasticity Info TrialSpasticity reliefManyALL2Recruiting52031MS21.562002025-06-052026-11-182027-01-27
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30Urolithin A (Mitopure) on Cognitive Function Trial Mitochpndria Cognitive decline Brain FogUSAALLPilotRecruitingAvailable Now OTCAging11.516502025-07-292025-122026-12
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31UCSF, NAC (N-Acetyl Cysteine) Glucose regulation Anti-inflammatory MitochondriaUSARR2Active, Not Recruiting1.5Available Now OTCMS21.56982022-02-162027-022027-02
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32Alpha Lipoic Acid InfoNeuroprotective Slows brain atrophyUSASP2Completed Published 2017.3Available Now OTCMS21.56
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33TUDCA Bile acid supplement Info.Neuroprotective Anti-inflammatory USASP1/2Completed Published 2024.5.5Available Now OTCMS21.562018-06-192022-04-282022-07-05
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34AndrographisRemyelinationRR2Completed Published3Available Now OTCMS21.56362020-09-222027-02-222027-05-31
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35GeNeuro, Temelimab Neuroregenerative Immunomodulator ManyTreat2Completed Oct 2023 Published42030MS ALS LCovid228
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The TAF-MS study: Tenofovir alafenamide fumarate (TAF) for EBV in MS Info & TrialsEBV Antiviral NorwayRRTreatPilotRecruiting32029MS22.510
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36Harvard, Antivirals for EBV in MSEBV Antiviral USA HarvardRRTreatPilotCompleted 42030MS22.510502023-06-052025-06-042025-12-31
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37Haukeland Univ. Intrathecal Stem Cells TrialNeuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingNorwaySP1/2Active, Not Recruiting42030MS22.510182021-08-092024-10-042025-01-04
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38Umbilical Cord Stem Cells IV & Intrathecal (UMSC01) TrialNeuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingTaiwanRR1/2Recruiting52031MS22.5104109/08/202312/31/20262026-12-31
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39Intrathecal Amniotic Fluid Stem Cells for Progressive MS TrialNeuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingUSA NCSP PP1/2Withdrawn52031MS22.510202026-02-012026-08-012026-11-01
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40Extracorporeal Photopheresis (ECP) Info1 Info2 Trial. Neuroregenerative Anti-inflammatory Immunomodulator UAESP1/2Active, Not Recruiting3.52029.5MS22.510152022-03-262025-032025-06
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41Oculis, OCS-05 Info Trial Neuroregenerative Anti-inflammatoryFranceOptic Neuritis2aRecruiting52031MS ON PD Glaucoma Epilepsy22Orphan drug designation192022-12-192024-09-162024-09-16
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42Dendritic Cells Therapy Combined With Immunomodulatory Treatment Trial MBP-tolerizingSpainRRTreat2Active, Not Recruiting42030MS228452020-01-272025-062025-06
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43Alumis Inc., A-005 Info 2026TYK2 Inhibitor fully CNS-penetrant ↓ Microglial Activity Anti-inflammatory USAMS2Starts 1st half 202652031MS PD228
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44Sudo Bio, SUDO-550 InfoTYK2 Inhibitor fully CNS-penetrant ↓ Microglial Activity Anti-inflammatory USAMS1Starts 2nd half 202642030PMS2282023-11-062025-082025-09
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45Ifenprodil TrialRemyelinationFranceRR2Not Yet Recruiting52031MS22Orphan drug designation19602024-03-012027-03-012027-06-01
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46Low Dose Naltrexone Trial Info on LDN & Prescribers Anti-inflammatoryManyALL2Recruiting or Off-label prescription32029MS LCovid ME/CFS21.5Orphan drug designation16
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47MediciNova, Ibudilast MN-166 Neuroprotective Anti-inflammatory Slow-brain-atrophyUSASP PP2Completed Published. 2018 2024.32029MS 21.56
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48Hydroxychloroquine HCQ↓ Microglial Activity Delays progressionCanadaPP2Off-label Published 2022 2023.42030MS RA21.56
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49RapamycinInhibits mTOR Less plaques, Improve EDSS, Regulatory T-cells Anti-inflammatoryUSARRTreatPilotCompleted Published 2018MS LCovid ME/CFS11.522018-06-192022-04-282022-07-0559
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50Spinal Cord Neuromodulator (SCONE™) for Neurogenic Bladder Info TrialSpinal cord neuromodulationUSA Canada IndiaALL2Recruiting32029MS SCI Stroke21.5Orphan drug designation17
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51TAURUS2 Magnetic Stim Myelin Info TrialRemyelinationAustraliaALL2Recruiting32029MS21.561082024-11-222024-08-2024
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52Transcranial Magnetic Stimulation There are 10 trials .DepressionALLRecruitingTrials or Avilable Now 21.56
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53SetPoint System Vagus Nerve Stimulation for Remyelination Info Trial RemyelinationUSARRPilotRecruiting Q4 202582034MS RA02.57
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54Noninvasive Vagal Nerve Stimulation (VANISH-MS) Info Trial Neuroplasticity Motor FunctionUSA NYALLPilotRecruiting52031026302025-02-052025-02-052026-05-05
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55Vagus Nerve Stimulation for Functional Recovery Info TrialNeuroplasticity Motor FunctionUSA COALLPilotRecruiting52031Long Covid ME/CFS02Breakthrough Device26552025-01-052025-06-05
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56Acute Intermittent Hypoxia TrialNeuroplasticity Motor FunctionUSA ChicagoRR2Completed Published 2024.32029MS21.56212024-04-302026-01-012027-01-01
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57New Gadolinium-Free MRI Contrast Agent - RVP-001A safey trial to test an alternative to gadolinium-based contrast agentUSA CT MAAll2Recruiting2
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58TG Therapeutics Azer-cel Anti-CD19 CAR-T Cell Info Trial What is CAR-T Cell Allogeneic CAR-T Cell Therapy - Immune System ResetUSA La Jolla CASP PPTreat1Recruiting62032MS1.5318325/6/202506/01/20272026-122029-01-01
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59Kyverna, KYV-101 CAR-T Cell Trial Early ResultsAutologus CAR-T Cell Therapy - Immune System ResetUSA StanfordSP PPTreat1Recruiting62032MS1.5318124/10/202406/01/20272027-06
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60KernalBio, KR-402 CAR-T therapy w/ NO chemoAutologus CAR-T Cell Therapy - Immune System Reset - No chemoUSA StanfordPMSTreat1Planned72033MS1.537
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61Kyverna, KYV-101 CAR-T Cell Trial Early ResultsAutologus CAR-T Cell Therapy - Immune System ResetUSA UCLASP PPTreat1Active, Not Recruiting62032MS1.537106/20/202406/01/20262027-06
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62Novartis, YTB323 CAR-T Cell RRMS Trial TrialAutologus CAR-T Cell Therapy - Immune System ResetAustralia Europe RRTreat1/2Recruiting62032MS1.537282/24/202510/01/203010/01/2030
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63AstraZeneca, AZD0120 (ZENITH) CAR-T Cell Trial Autologus CAR-T Cell Therapy - Immune System ResetAustralia USA CanadaALLTreat1bRecruiting62032MS1.5372412/9/202512/07/202812/07/2028
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64Bristol Myers, (CC-97540) CAR-T Trial Autologus CAR-T Cell Therapy - Immune System ResetUSASP PPTreat1Recruiting62032MS MG1.53712003/28/20242027-07-152027-07-15
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65University College London Hospital, AUTO1-MS1 Obe-cel CAR-T Info Trial Autologus CAR-T Cell Therapy - Immune System ResetUK LondonSP PPTreat1Recruiting62032MS MG1.537182025-08-042029-08-152029-08-15
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Cabaletta Bio, CABA-201 (RESET-MS) CAR-T Cell TrialAutologus CAR-T Cell Therapy - Immune System ResetTBDRR SP PPTreat1/2Not Yet Recruiting#VALUE!#VALUE!MS MG SLE23Fast Track12122026-06-012028-09-012029-10
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66Iaso, Eque-cel CAR-T Interim Results TrialAutologus CAR-T Cell Therapy - Immune System ResetChinaSP PPTreat1Recruiting 62032MS1.537362020-09-222027-02-22292Total
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68Abata, ABA-101 Info TrialRegulatory T-cells (Tregs) RemyelinationUSASP PP1Completed 202462032MS13Fast Track36
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69Anokion, ANK-700 Inverse Vaccine Trial Results Immune-tolerance USARRTreat1Completed Published.52031MS CD T1D1.52.5Break- through Therapy 39
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70Lapix, LPX-TI641 Info TrialIimmune-tolerance USA, JordanALL1Completed Nov 202452031MS NMOSD MOGAD RA PsA1.5252023-10-302024-04-152024-08-01
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71Fibrobiologics CYMS101 InfoRemyelinationUSARR1Completed 04/05/202562032MS DDD DWC SLE1.52.56
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72FSD Pharma, Lucid-MS Info Trial Non-immunomodulatory RemyelinationCanadaRR1Completed 12/23/202562032MS1.525162024-09-282025-01-242025-01-24
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73Sudo Biosciences, SUDO-550 TYK2 Inhibitor Trial ↓ Microglial Activity Neurovascular Anti-inflammatoryRR SP PP1Completed Nov 2025 Ph 2 planned Q2 202662032MS1.52.56
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74Alumis, A-005 TYK2 Inhibitor Trial ↓ Microglial Activity Neurovascular Anti-inflammatory1Completed 12/19/202462032MS1.52.56
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75Brenig, BT-409 InfoBlocks NLRP3 inflammasome Anti-inflammatoryHealthy volunteers1Planned82034MS1.52.56
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76Neuron23, NEU-627 TYK2 Inhibitor Info Trial ↓ Microglial Activity Neurovascular Anti-inflammatoryNew ZealandHealthy volunteers1Recruiting72033MS PD 1222025-06-022025-112025-11
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77Allogenic Adipose MSC Stem Cells Intrathecal for PPMS (MAESTRO-4MS) TrialNeuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingFrancePP1Recruiting62032MS12.53102025-03-062029-12-012029-12-01
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78ImStem, Stem Cells Info Trial Neuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingUSA GeorgiaRR SP1Recruiting62032MS12.53302021-08-312027-04-012027-04-01
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79Neural Stem Cells Brain Injections Info1 Info2 Trial.Neuroregenerative Anti-inflammatory Immunomodulator MBP-tolerizingUSA CO ItalySP1Completed Published 202352031MS12.53152017-09-092021-05-292021-05-29
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80Duke Univ, Stem Cells TrialNeuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingUSAPP1Recruiting62032MS22.510202021-01-242025-08-302025-08-30
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81Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration MS & ALS (CONTRASTOME) Trial Neuroregenerative Anti-inflammatory ↓Microglial Activity MBP-tolerizingItalyALL MS & ALSPilotRecruiting72033MS ALS12.53602025-01-172026-03-312026-09-30
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82Ixazomib SIZOMUS Trial InfoImmunomodulatorUK LondonALL1Recruiting52031MS Cancer122722020-08-202026-07-312026-07-31
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83Indapta, IDP-023 (natural killer cells) + Ocrevus Trial InfoRemove pathogenic immnue cells that cause inflammationUSASP PPTreat1Suspended 2025 May resume62032MS Cancer122342026-06-302026-12-312028-12-31