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SAR443820 Info Trial (Europe)
SAR443820 Info Trial (Europe)
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SolvingMS.org MS Research Database
https://SolvingMS.orgAs of:6/5/2023
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MS Trial Finder - Enroll in Recruiting Trials!
Calculations for Overall Score
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Scroll down for heading definitions
Copyright © 2023 Solving MS - All Rights Reserved
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1Trial Name234567891011
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#Overall ScoreClick for Research Profile & Trial Enrollment InfoMS Type For TrialEBV RxFDA Trial PhasePhase StatusYears to Phase 4 Prescribe Phase 4 Phase Score Most Weight Effective- nessFDA Acceler- ation Phase Score^2 xEffectiveness +Fast TrackTrial StartTrial End
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125Immunic, Vidofludimus CalciumRRTreat3Recruiting3202632.7524.75
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225Immunic, Vidofludimus CalciumSP PPTreat2Recruiting3202632.7524.75RR 23 Trials
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324Atara, ATA188SP PPTreat3Planned520282.753123.6875
SP
12 Trials
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423BTKi TolebrutinibALL3Partial Hold Jun 20222202532.522.5
PP
12 Trials
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523BTKi MastinibSP PP3Recruiting2202532.522.5EBV10 Trials
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623BTKi FenebrutinibRR PP3Recruiting2202532.522.55MSC Stem Cell Trials
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723BTKI Evobrutinib * TrialsRR3Recruiting4202732.522.55EBV Vaccine Trials
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823BTKI Remibrutinib * TrialsRR3Recruiting4202732.522.5130
See All Therapies tab
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919Tisch MS Center, Stem Cells SP PP3Planned520282.52.5318.62537Selected to profile
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1023Sanofi, Frexalimab * InfoRRTreat2Published520282.75322.6875
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1019Clene, CNM-Au8 nanogold * InfoRR2Completed520282.5318.75
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1112Clene, CNM-Au8 nanogold * InfoSP PP2Recruiting720302312
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1216BTKI Orelabrutinib * TrialsRR2Pattal Hold Dec 26 2022520282.52.515.62515Profiles completed
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1316Brainstorm, Nurown Stem Cells SP PP2Published5.520292.52.515.625
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1414Octopus MS UK, Metformin, ALA TrialSP3Recruiting5202831.513.5
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1513Geneuro, Temelimab RR2Published5.520292.5212.5
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1612Nervgen, NVG-291RR2Q1 20247.520312312
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1710Antivirals for EBV in MSALLTreat2PendingPending funding22.510
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1810Famciclovir for EBV in MS * TrialALLTreat2Recruiting or Off-label4202722.510
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1910Hope Biosciences, Stem Cells RR2Recruiting or RightToTry6.5203022.510
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2010Duke Univ, MSC Stem Cells * TrialPP2Recruiting7203022.510
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2111Tiziana, Foralumab * InfoSP PP2Q4 20237.5203122.5111
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226TAURUS2 Magnetic Stim Myelin Info TrialALL2Recruiting7203021.56
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236Metformin & AMPKRR2Recruiting or Off-label7203021.56
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246Clemastine-Myelin Repair * TrialRR2Recruiting or Off-label7203021.56
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256NAC (N-Acetyl Cysteine) RR2Recruiting or OTC7203021.56
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268SAR443820 Info Trial (Europe)RR SP2Recruiting7203222812/19/202208/27/2025
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276Pipeline, PIPE-307 Clemastine * InfoTreat2Recruits '227.5203121.56
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285MPB Tolerizing Vaccine * Trial Spain ALLTreat2Recruiting620291.524.520202024
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294 Imcyse, IMCY-0141 * Info TrialRRTreat1Recruiting82031144
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303ImStem, Stem Cells * Info TrialRR SP1Recruiting8203112.52.5
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313Synaptogenix, Bryostatin-1 * InfoRR1Planned8.52032133
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322Anokion MS Vaccine * Trial InfoRRTreat1Recruiting7.52031122
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332Moderna EBV 1195 Vaccine * InfoALLTreat1Recruiting82031122
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342NIH, EBV MS Vaccine * Info TrialSP PPPrevent1Recruiting82031122
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352LPX-TI641 InfoALL1Planned July 20231122
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362Pasithea, MS Vaccine * InfoALLTreat0Published1020330.5211.5
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Best viewed on a screen larger than a mobile phone.
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* Profiles coming soon! Link to ClinicalTrials page provided if available.
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Click any trial name for the Research Profile with full details on the therapy and links to trial enrollment.
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Before you discuss a trial with your doctor, contact the trial coordinator to see if you meet inclusion/exclusion criteria.
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Click All Therapies tab at bottom of screen for all 100+ therapies in the database.
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Click HERE to join the Solving MS research study group. Members are discussing and joining these trials!
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Column Heading Definitions
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Overall Score - most weight given to therapies closest to FDA approval.
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Overall Score formula = Phase Score^2 xEffectiveness +FDA Acceleration
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MS Type
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RRTrial is for Relapsing Remitting MS
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SPTrial is for Secondary Progressive MS
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PPTrial is for Primary Progressive MS
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EBV Rx - Therapy targets Epstein Barr virus, the probable cause of MS
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4FDA Trial PhasePhase TypeYears to Ph 4 from start- Years to complete phase= Years to Phase 4 from complete
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0Pre Clinical - Cell and animal studies123.58.5
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1Phase 1 - Test safety in 20-100 humans8.517.5
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Phase 2 - Test effectiveness in 100-300 humans
7.525.5
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Phase 3 - Safety & effectiveness in 1000+ humans.
5.532.5
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4
Review - FDA review of Phase 3 to approve Phase 4
2.52.50
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N/A
Phase 4 - Can now be prescribed & paid for by insurance
Varies
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Note: Average times for trial completion. Issues such as funding delays can prolong the timeline.
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Phase Status
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Complete - Trial phase is finished, awaiting review, publication of results, and funding for next phase
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Planned - Trial announced but recruiting has not started and there is no page yet at ClinicalTrials.org.
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Recruiting - Trial is actively enrolling, click trial name for full profile with links to contact information.
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Note: If Complete, you can contact trial coordinator to see when next phase starts.
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Years to Phase 4 from today
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Phase 4 by - The year it is estimated to become available.
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"When can I get it?" Phase 4 is when it can be prescribed
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Very important for progressed patients who don't meet inclusion criteria for trials.
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Phase Score Most Weight
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If phase = complete then add +0.5 to phase score
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9Scorefor Effectiveness
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1Remission, allowing innate repair.
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2Cure, allowing innate repair.
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3Remission, plus extra repair mechanism.
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4Cure, plus extra repair mechanism.
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Note: These are estimates, as actual effects may not be determined yet.
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10Score
FDA Acceleration Program - can accelerate trial completion
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FDA Fast Track - Associated with animal data
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Breakthrough Therapy - Associated with clinical trial data.
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Expanded Access Program - Patients who don't meet inclusion criteria can join phase 3 trials.