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Study numberRankTitleJournalAuthorsYearVolumeIssueBeginning pageDOI
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11A coding-independent function of gene and pseudogene mRNAs regulates tumour biologyNaturePoliseno L., Salmena L., Zhang J., Carver B., Haveman W.J., Pandolfi P.P.20104657301103310.1038/nature09144
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22A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell SubpopulationsCellJSharma S.V., Lee D.Y., Li B., Quinlan M.P., Takahashi F., Maheswaran S., McDermott U., Azizian N., Zou L., Fischbach M.A., Wong K.-K., Brandstetter K., Wittner B., Ramaswamy S., Classon M., Settleman J.201014116910.1016/j.cell.2010.02.027
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33Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasisNatureGupta R.A., Shah N., Wang K.C., Kim J., Horlings H.M., Wong D.J., Tsai M.-C., Hung T., Argani P., Rinn J.L., Wang Y., Brzoska P., Kong B., Li R., West R.B., Van De Vijver M.J., Sukumar S., Chang H.Y.20104647291107110.1038/nature08975
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44Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic DifferentiationCancer CellFigueroa M.E., Abdel-Wahab O., Lu C., Ward P.S., Patel J., Shih A., Li Y., Bhagwat N., Vasanthakumar A., Fernandez H.F., Tallman M.S., Sun Z., Wolniak K., Peeters J.K., Liu W., Choe S.E., Fantin V.R., Paietta E., Lowenberg B., Licht J.D., Godley L.A., Delwel R., Valk P.J.M., Thompson C.B., Levine R.L., Melnick A.201018655310.1016/j.ccr.2010.11.015
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55Tumour vascularization via endothelial differentiation of glioblastoma stem-like cellsNatureRicci-Vitiani L., Pallini R., Biffoni M., Todaro M., Invernici G., Cenci T., Maira G., Parati E.A., Stassi G., Larocca L.M., De Maria R.2010468732582410.1038/nature09557
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66Diverse somatic mutation patterns and pathway alterations in human cancersNatureKan Z., Jaiswal B.S., Stinson J., Janakiraman V., Bhatt D., Stern H.M., Yue P., Haverty P.M., Bourgon R., Zheng J., Moorhead M., Chaudhuri S., Tomsho L.P., Peters B.A., Pujara K., Cordes S., Davis D.P., Carlton V.E.H., Yuan W., Li L., Wang W., Eigenbrot C., Kaminker J.S., Eberhard D.A., Waring P., Schuster S.C., Modrusan Z., Zhang Z., Stokoe D., De Sauvage F.J., Faham M., Seshagiri S.2010466730886910.1038/nature09208
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77Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAFCellHeidorn S.J., Milagre C., Whittaker S., Nourry A., Niculescu-Duvas I., Dhomen N., Hussain J., Reis-Filho J.S., Springer C.J., Pritchard C., Marais R.2010140220910.1016/j.cell.2009.12.040
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88RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthNatureHatzivassiliou G., Song K., Yen I., Brandhuber B.J., Anderson D.J., Alvarado R., Ludlam M.J.C., Stokoe D., Gloor S.L., Vigers G., Morales T., Aliagas I., Liu B., Sideris S., Hoeflich K.P., Jaiswal B.S., Seshagiri S., Koeppen H., Belvin M., Friedman L.S., Malek S.2010464728743110.1038/nature08833
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99Wnt activity defines colon cancer stem cells and is regulated by the microenvironmentNature Cell BiologyVermeulen L., De Sousa E Melo F., Van Der Heijden M., Cameron K., De Jong J.H., Borovski T., Tuynman J.B., Todaro M., Merz C., Rodermond H., Sprick M.R., Kemper K., Richel D.J., Stassi G., Medema J.P.201012546810.1038/ncb2048
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1010The transcriptional network for mesenchymal transformation of brain tumoursNatureCarro M.S., Lim W.K., Alvarez M.J., Bollo R.J., Zhao X., Snyder E.Y., Sulman E.P., Anne S.L., Doetsch F., Colman H., Lasorella A., Aldape K., Califano A., Iavarone A.2010463727931810.1038/nature08712
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1111Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationNatureNazarian R., Shi H., Wang Q., Kong X., Koya R.C., Lee H., Chen Z., Lee M.-K., Attar N., Sazegar H., Chodon T., Nelson S.F., McArthur G., Sosman J.A., Ribas A., Lo R.S.2010468732697310.1038/nature09626
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1212COT drives resistance to RAF inhibition through MAP kinase pathway reactivationNatureJohannessen C.M., Boehm J.S., Kim S.Y., Thomas S.R., Wardwell L., Johnson L.A., Emery C.M., Stransky N., Cogdill A.P., Barretina J., Caponigro G., Hieronymus H., Murray R.R., Salehi-Ashtiani K., Hill D.E., Vidal M., Zhao J.J., Yang X.P., Alkan O., Kim S., Harris J.L., Wilson C.J., Myer V.E., Finan P.M., Root D.E., Roberts T.M., Golub T., Flaherty K.T., Dummer R., Weber B.L., Sellers W.R., Schlegel R., Wargo J.A., Hahn W.C., Garraway L.A.2010468732696810.1038/nature09627
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1313A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription ProgramsCellKim J., Woo A.J., Chu J., Snow J.W., Fujiwara Y., Kim C.G., Cantor A.B., Orkin S.H.2010143231310.1016/j.cell.2010.09.010
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1414RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFNaturePoulikakos P.I., Zhang C., Bollag G., Shokat K.M., Rosen N.2010464728742710.1038/nature08902
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1515Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer DrugsScienceSugahara K.N., Teesalu T., Prakash Karmali P., Ramana Kotamraju V., Agemy L., Greenwald D.R., Ruoslahti E.20103285981103110.1126/science.1183057
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1616The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting alpha-Ketoglutarate to 2-HydroxyglutarateCancer CellWard P.S., Patel J., Wise D.R., Abdel-Wahab O., Bennett B.D., Coller H.A., Cross J.R., Fantin V.R., Hedvat C.V., Perl A.E., Rabinowitz J.D., Carroll M., Su S.M., Sharp K.A., Levine R.L., Thompson C.B.201017322510.1016/j.ccr.2010.01.020
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1717Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2NatureKo M., Huang Y., Jankowska A.M., Pape U.J., Tahiliani M., Bandukwala H.S., An J., Lamperti E.D., Koh K.P., Ganetzky R., Liu X.S., Aravind L., Agarwal S., MacIejewski J.P., Rao A.2010468732583910.1038/nature09586
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181RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaNatureZuber J., Shi J., Wang E., Rappaport A.R., Herrmann H., Sison E.A., Magoon D., Qi J., Blatt K., Wunderlich M., Taylor M.J., Johns C., Chicas A., Mulloy J.C., Kogan S.C., Brown P., Valent P., Bradner J.E., Lowe S.W., Vakoc C.R.2011478737052410.1038/nature10334
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192BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-MycCellDelmore J.E., Issa G.C., Lemieux M.E., Rahl P.B., Shi J., Jacobs H.M., Kastritis E., Gilpatrick T., Paranal R.M., Qi J., Chesi M., Schinzel A.C., McKeown M.R., Heffernan T.P., Vakoc C.R., Bergsagel P.L., Ghobrial I.M., Richardson P.G., Young R.A., Hahn W.C., Anderson K.C., Kung A.L., Bradner J.E., Mitsiades C.S.2011146690310.1016/j.cell.2011.08.017
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203Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and MetastasisCellGoetz J.G., Minguet S., Navarro-Lerida I., Lazcano J.J., Samaniego R., Calvo E., Tello M., Osteso-Ibanez T., Pellinen T., Echarri A., Cerezo A., Klein-Szanto A.J.P., Garcia R., Keely P.J., Sanchez-Mateos P., Cukierman E., Del Pozo M.A.2011146114810.1016/j.cell.2011.05.040
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214Discovery and preclinical validation of drug indications using compendia of public gene expression dataScience Translational MedicineSirota M., Dudley J.T., Kim J., Chiang A.P., Morgan A.A., Sweet-Cordero A., Sage J., Butte A.J.201139696ra7710.1126/scitranslmed.3001318
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225Selective killing of cancer cells by a small molecule targeting the stress response to ROSNatureRaj L., Ide T., Gurkar A.U., Foley M., Schenone M., Li X., Tolliday N.J., Golub T.R., Carr S.A., Shamji A.F., Stern A.M., Mandinova A., Schreiber S.L., Lee S.W.2011475735523110.1038/nature10167
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236Functional genomics reveal that the serine synthesis pathway is essential in breast cancerNaturePossemato R., Marks K.M., Shaul Y.D., Pacold M.E., Kim D., Birsoy K., Sethumadhavan S., Woo H.-K., Jang H.G., Jha A.K., Chen W.W., Barrett F.G., Stransky N., Tsun Z.-Y., Cowley G.S., Barretina J., Kalaany N.Y., Hsu P.P., Ottina K., Chan A.M., Yuan B., Garraway L.A., Root D.E., Mino-Kenudson M., Brachtel E.F., Driggers E.M., Sabatini D.M.2011476736034610.1038/nature10350
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247Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAsCellTay Y., Kats L., Salmena L., Weiss D., Tan S.M., Ala U., Karreth F., Poliseno L., Provero P., Di Cunto F., Lieberman J., Rigoutsos I., Pandolfi P.P.2011147234410.1016/j.cell.2011.09.029
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258Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of alpha-Ketoglutarate-Dependent DioxygenasesCancer CellXu W., Yang H., Liu Y., Yang Y., Wang P., Kim S.-H., Ito S., Yang C., Wang P., Xiao M.-T., Liu L.-X., Jiang W.-Q., Liu J., Zhang J.-Y., Wang B., Frye S., Zhang Y., Xu Y.-H., Lei Q.-Y., Guan K.-L., Zhao S.-M., Xiong Y.20111911710.1016/j.ccr.2010.12.014
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269Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisNatureDeNicola G.M., Karreth F.A., Humpton T.J., Gopinathan A., Wei C., Frese K., Mangal D., Yu K.H., Yeo C.J., Calhoun E.S., Scrimieri F., Winter J.M., Hruban R.H., Iacobuzio-Donahue C., Kern S.E., Blair I.A., Tuveson D.A.2011475735410610.1038/nature10189
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2710BRCA1 tumour suppression occurs via heterochromatin-mediated silencingNatureZhu Q., Pao G.M., Huynh A.M., Suh H., Tonnu N., Nederlof P.M., Gage F.H., Verma I.M.2011477736317910.1038/nature10371
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2811The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44Nature MedicineLiu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., Patrawala L., Yan H., Jeter C., Honorio S., Wiggins J.F., Bader A.G., Fagin R., Brown D., Tang D.G.201117221110.1038/nm.2284
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2912Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNatureDawson M.A., Prinjha R.K., Dittmann A., Giotopoulos G., Bantscheff M., Chan W.-I., Robson S.C., Chung C.-W., Hopf C., Savitski M.M., Huthmacher C., Gudgin E., Lugo D., Beinke S., Chapman T.D., Roberts E.J., Soden P.E., Auger K.R., Mirguet O., Doehner K., Delwel R., Burnett A.K., Jeffrey P., Drewes G., Lee K., Huntly B.J.P., Kouzarides T.2011478737052910.1038/nature10509
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3013CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisNatureQian B.-Z., Li J., Zhang H., Kitamura T., Zhang J., Campion L.R., Kaiser E.A., Snyder L.A., Pollard J.W.2011475735522210.1038/nature10138
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3114An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in GlioblastomaCellSumazin P., Yang X., Chiu H.-S., Chung W.-J., Iyer A., Llobet-Navas D., Rajbhandari P., Bansal M., Guarnieri P., Silva J., Califano A.2011147237010.1016/j.cell.2011.09.041
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3215Normal and neoplastic nonstem cells can spontaneously convert to a stem-like statePNASChaffer C.L., Brueckmann I., Scheel C., Kaestli A.J., Wiggins P.A., Rodrigues L.O., Brooks M., Reinhardt F., Suc Y., Polyak K., Arendt L.M., Kuperwasser C., Bierie B., Weinberg R.A.201110819795010.1073/pnas.1102454108
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3316An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptorNatureOpitz C.A., Litzenburger U.M., Sahm F., Ott M., Tritschler I., Trump S., Schumacher T., Jestaedt L., Schrenk D., Weller M., Jugold M., Guillemin G.J., Miller C.L., Lutz C., Radlwimmer B., Lehmann I., von Deimling A., Wick W., Platten M.2011478736819710.1038/nature10491
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3417Senescence surveillance of pre-malignant hepatocytes limits liver cancer developmentNatureKang T.W., Yevsa T., Woller N., Hoenicke L., Wuestefeld T., Dauch D., Hohmeyer A., Gereke M., Rudalska R., Potapova A., Iken M., Vucur M., Weiss S., Heikenwalder M., Khan S., Gil J., Bruder D., Manns M., Schirmacher P., Tacke F., Ott M., Luedde T., Longerich T., Kubicka S., Zender L.2011479737454710.1038/nature10599
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351A restricted cell population propagates glioblastoma growth after chemotherapyNatureChen J., Li Y., Yu T.-S., McKay R.M., Burns D.K., Kernie S.G., Parada L.F.2012488741252210.1038/nature11287
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362Defining the mode of tumour growth by clonal analysisNatureDriessens G., Beck B., Caauwe A., Simons B.D., Blanpain C.2012488741252710.1038/nature11344
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373Systematic identification of genomic markers of drug sensitivity in cancer cellsNatureGarnett M.J., Edelman E.J., Heidorn S.J., Greenman C.D., Dastur A., Lau K.W., Greninger P., Thompson I.R., Luo X., Soares J., Liu Q., Iorio F., Surdez D., Chen L., Milano R.J., Bignell G.R., Tam A.T., Davies H., Stevenson J.A., Barthorpe S., Lutz S.R., Kogera F., Lawrence K., McLaren-Douglas A., Mitropoulos X., Mironenko T., Thi H., Richardson L., Zhou W., Jewitt F., Zhang T., O'Brien P., Boisvert J.L., Price S., Hur W., Yang W., Deng X., Butler A., Choi H.G., Chang J.W., Baselga J., Stamenkovic I., Engelman J.A., Sharma S.V., Delattre O., Saez-Rodriguez J., Gray N.S., Settleman J., Futreal P.A., Haber D.A., Stratton M.R., Ramaswamy S., McDermott U., Benes C.H.2012483739157010.1038/nature11005
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384Lineage Tracing Reveals Lgr5(+) Stem Cell Activity in Mouse Intestinal AdenomasScienceSchepers A.G., Snippert H.J., Stange D.E., Van Den Born M., Van Es J.H., Van De Wetering M., Clevers H.2012337609573010.1126/science.1224676
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395The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsPNASWillingham S.B., Volkmer J.-P., Gentles A.J., Sahoo D., Dalerba P., Mitra S.S., Wang J., Contreras-Trujillo H., Martin R., Cohen J.D., Lovelace P., Scheeren F.A., Chao M.P., Weiskopf K., Tang C., Volkmer A.K., Naik T.J., Storm T.A., Mosley A.R., Edris B., Schmid S.M., Sun C.K., Chua M.-S., Murillo O., Rajendran P., Cha A.C., Chin R.K., Kim D., Adorno M., Raveh T., Tseng D., Jaiswal S., Enger P.O., Steinberg G.K., Li G., So S.K., Majeti R., Harsh G.R., Van Rijn M.D., Teng N.N.H., Sunwoo J.B., Alizadeh A.A., Clarke M.F., Weissman I.L.201210917666210.1073/pnas.1121623109
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406Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretionNatureStraussman R., Morikawa T., Shee K., Barzily-Rokni M., Qian Z.R., Du J., Davis A., Mongare M.M., Gould J., Frederick D.T., Cooper Z.A., Chapman P.B., Solit D.B., Ribas A., Lo R.S., Flaherty K.T., Ogino S., Wargo J.A., Golub T.R.2012487740850010.1038/nature11183
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417Intestinal Inflammation Targets Cancer-Inducing Activity of the MicrobiotaScienceArthur J.C., Perez-Chanona E., Muhlbauer M., Tomkovich S., Uronis J.M., Fan T.-J., Campbell B.J., Abujamel T., Dogan B., Rogers A.B., Rhodes J.M., Stintzi A., Simpson K.W., Hansen J.J., Keku T.O., Fodor A.A., Jobin C.2012338610312010.1126/science.1224820
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428Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METNature MedicinePeinado H., Aleckovic M., Lavotshkin S., Matei I., Costa-Silva B., Moreno-Bueno G., Hergueta-Redondo M., Williams C., Garcia-Santos G., Ghajar C.M., Nitadori-Hoshino A., Hoffman C., Badal K., Garcia B.A., Callahan M.K., Yuan J., Martins V.R., Skog J., Kaplan R.N., Brady M.S., Wolchok J.D., Chapman P.B., Kang Y., Bromberg J., Lyden D.201218688310.1038/nm.2753
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439Interactions between cancer stem cells and their niche govern metastatic colonizationNatureMalanchi I., Santamaria-Martinez A., Susanto E., Peng H., Lehr H.A., Delaloye J.F., Huelsken J.201248173798510.1038/nature10694
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4410Melanoma genome sequencing reveals frequent PREX2 mutationsNatureBerger M.F., Hodis E., Heffernan T.P., Deribe Y.L., Lawrence M.S., Protopopov A., Ivanova E., Watson I.R., Nickerson E., Ghosh P., Zhang H., Zeid R., Ren X., Cibulskis K., Sivachenko A.Y., Wagle N., Sucker A., Sougnez C., Onofrio R., Ambrogio L., Auclair D., Fennell T., Carter S.L., Drier Y., Stojanov P., Singer M.A., Voet D., Jing R., Saksena G., Barretina J., Ramos A.H., Pugh T.J., Stransky N., Parkin M., Winckler W., Mahan S., Ardlie K., Baldwin J., Wargo J., Schadendorf D., Meyerson M., Gabriel S.B., Golub T.R., Wagner S.N., Lander E.S., Getz G., Chin L., Garraway L.A.2012485739950210.1038/nature11071
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4511Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFRNaturePrahallad A., Sun C., Huang S., Di Nicolantonio F., Salazar R., Zecchin D., Beijersbergen R.L., Bardelli A., Bernards R.2012483738710010.1038/nature10868
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4612Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureWilson T.R., Fridlyand J., Yan Y., Penuel E., Burton L., Chan E., Peng J., Lin E., Wang Y., Sosman J., Ribas A., Li J., Moffat J., Sutherlin D.P., Koeppen H., Merchant M., Neve R., Settleman J.2012487740850510.1038/nature11249
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4713IDH mutation impairs histone demethylation and results in a block to cell differentiationNatureLu C., Ward P.S., Kapoor G.S., Rohle D., Turcan S., Abdel-Wahab O., Edwards C.R., Khanin R., Figueroa M.E., Melnick A., Wellen K.E., Ogrourke D.M., Berger S.L., Chan T.A., Levine R.L., Mellinghoff I.K., Thompson C.B.2012483739047410.1038/nature10860
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4814Transcriptional Amplification in Tumor Cells with Elevated c-MycCellLin C.Y., Loven J., Rahl P.B., Paranal R.M., Burge C.B., Bradner J.E., Lee T.I., Young R.A.201215115610.1016/j.cell.2012.08.026
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4915Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling NetworksCellLee M.J., Ye A.S., Gardino A.K., Heijink A.M., Sorger P.K., MacBeath G., Yaffe M.B.2012149478010.1016/j.cell.2012.03.031
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5016Fusobacterium nucleatum infection is prevalent in human colorectal carcinomaGenome ResearchCastellarin M., Warren R.L., Freeman J.D., Dreolini L., Krzywinski M., Strauss J., Barnes R., Watson P., Allen-Vercoe E., Moore R.A., Holt R.A.201222229910.1101/gr.126516.111
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5117DNA breaks and chromosome pulverization from errors in mitosisNatureCrasta K., Ganem N.J., Dagher R., Lantermann A.B., Ivanova E.V., Pan Y., Nezi L., Protopopov A., Chowdhury D., Pellman D.201248273835310.1038/nature10802
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5218A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cellsNaturePng K.J., Halber N., Yoshida M., Tavazoie S.F.2012481738019010.1038/nature10661
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5319Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxiaNatureMetallo C.M., Gameiro P.A., Bell E.L., Mattaini K.R., Yang J., Hiller K., Jewell C.M., Johnson Z.R., Irvine D.J., Guarente L., Kelleher J.K., Vander Heiden M.G., Iliopoulos O., Stephanopoulos G.2012481738138010.1038/nature10602
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5418Somatic mutations altering EZH2 (Y641) in follicular and diffuse large B-cell lymphomas of germinal-center originNature GeneticsMorin R.D., Johnson N.A., Severson T.M., Mungall A.J., An J, Goya R., Paul J.E., Boyle M., Woolcock B.W., Kuchenbauer F., Yap D., Humphries R.K., Griffith O.L., Shah S., Zhu H., Kimbara M., Shashkin P., Charlot J.F., Tcherpakov M., Corbett R., Tam A., Varhol R., Smailus D., Moksa M., Zhao Y., Delaney A., Qian H., Birol I., Schein J., Moore R., Holt R., Horsman D.E., Connors J.M., Jones S., Aparicio S., Hirst M., Gascoyne R.D., Marra M.A.201052518110.1038/ng.518
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