EHC treatment- by-cohort data set.xlsx

	A	B	C	D	E	F	G	H	I	J	K	L	M	N	O	P	Q	R	S	T	U	V	W	X	Y	Z	AA	AB	AC	AD	AE	AF	AG	AH	AI	AJ	AK	AL	AM	AN	AO	AP	AQ	AR	AS	AT	AU	AV	AW	AX	AY	AZ	BA	BB	BC	BD	BE
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2	* This table is last updated on 21 May, 2026. Please note that the information will be periodically reviewed and updated according to the latest changes in the treatment ladscape. The information for this table was provided by the EHC NMOs and the industry. The EHC also wishes to thank the EHC MAG members for their input. * Treatment-by-cohort table is for educational purposes only, does not endorse or promote any specific pharmaceutical organisation, drug or other medical intervention. It is developed, created, and delivered by the EHC independently from the industry. If you find any inaccuracies, please report them at education@ehc.eu.							In this table, EHC covers only the markets of its 49 members. EU countries are marked in green for convenience, they include: Austria, Belgium, Bulgaria, Croatia, Republic of Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain and Sweden.								treatment options marked in yellow were reported by the industry or indicated by EMA as licensed in the relevant EU countries but are not included in the treatment option lists provided by the EHC NMOs.
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7	Bleeding Disorder	Type of Product	Recombinant	Plasma- derived	SHL/EHL/UHL	Molecule	Brand name	License	Albania	Armenia	Austria	Azerbaijan	Belarus	Belgium	Bosnia and Herzegovina	Bulgaria	Croatia	Republic of Cyprus	Czech Republic	Denmark	Estonia	Finland	France	Georgia	Germany	Greece	Hungary	Iceland	Ireland	Israel	Italy	Kazakhstan	Kyrgyz Republic	Latvia	Lithuania	Luxembourg	Malta	North Macedonia	Moldova	Montenegro	the Netherlands	Norway	Poland	Portugal	Romania	Russia	Serbia	Slovakia	Slovenia	Spain	Sweden	Switzerland	Tajikistan	Turkiye	Ukraine	UK	Uzbekistan
8	von Willebrand Disease (VWD)	VWF concentrate	x			vonicog alfa	Veyvondi/Vonvendi	Licensed in Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, UK						Veyvondi		Veyvondi	Veyvondi	Veyvondi	Veyvondi	Veyvondi	Veyvondi	Veyvondi	Veyvondi		Veyvondi 650, 1300	Veyvondi	Veyvondi	Veyvondi	Veyvondi		Veyvondi			Veyvondi 650, 1300	Veyvondi	Veyvondi	Veyvondi				Veyvondi	Veyvondi	Veyvondi	Veyvondi	Veyvondi			Veyvondi	Veyvondi	Veyvondi	Veyvondi	Veyvondi				Veyvondi
9				x		VWF	Wilfactin							Wilfactin 1000											Willfact 1000						Willfact
10		VWF/FVIII concentrate		x		VWF/FVIII	Voncento	Licensed in all EU countries, Switzerland, UK			Voncento			Voncento		Voncento	Voncento	Voncento	Voncento	Voncento	Voncento	Voncento	Voncento		Voncento 500/1200, 1000/2400	Voncento	Voncento		Voncento		Voncento			Voncento 250/600, 500/1200, 1000/2400	Voncento	Voncento	Voncento				Voncento		Voncento	Voncento	Voncento			Voncento	Voncento	Voncento	Voncento	Voncento				Voncento
11		VWF/FVIII concentrate		x		VWF/FVIII	Haemate-P/Humate-P	Licensed in Austria, Azerbaijan, Belarus, Belgium, Cyprus, Czechia, Denmark, Estonia, Finland, Germany, Greece, Hungary, Croatia, Israel, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Moldova, The Netherlands, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovenia, Slovakia, Spain, Sweden, Switzerland, Turkiye, Uzbekistan			Haemate-P	Haemate-P	Haemate-P	Haemate-P 500/1200, 1000/2400			Haemate 500/1200	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P			Haemate 250/600, 500/1200, 1000/2400	Haemate-P	Haemate-P			Haemate-P	Haemate-P	Haemate-P		Haemate-P	Haemate-P	Haemate-P			Haemate-P		Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P		Haemate-P	Haemate-P		Haemate-P
12				x		VWF/FVIII	Fanhdi/Alphanate																								Fanhdi and Alphanate
13				x		VWF/FVIII	Wilate						Wilate	Wilate 500/500, 1000/1000			Wilate 500/500			Wilnativ					Wilate 500/500, 1000/1000						Wilate			Wilate 500/500, 1000/1000
14				x		VWF/FVIII	Immunate/Immunate Stim Plus	Licensed in Albania, Austria, Belarus, Bulgaria, Crotia, Czechia, Estonia, Germany, Hungary, Italy, Kazakhstan, Latvia, Lithuania, Malta, North Macedonia, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Switzerland, Turkiye, Ukraine	Immunate		Immunate		Immunate			Immunate	Immunate		Immunate	Immunate Stim Plus	Immunate				Immunate Stim Plus - 500 I.E., 1000 I.E. : Nach Auflösen mit 5 ml (500 I.E. Packungsgröße) oder 10 ml (1000 I.E. Packungsgröße) sterilisiertem Wasser für Injektionszwecke enthält das Produkt 100 I.E./ml (500 I.E. und 1000 I.E. Packungsgröße) an Blutgerinnungsfaktor VIII vom Menschen und 60 I.E./ml (500 I.E. und 1000 I.E. Packungsgröße) an von-Willebrand-Faktor vom Menschen.		Immunate				Immunate	Immunate		Immunate 500SV/375SV Immunate 1000SV/750SV	Immunate		Immunate	Immunate					Immunate	Immunate	Immunate	Immunate	Immunate	Immunate	Immunate			Immunate		Immunate	Immunate
15		Desmopressin				Desmopressin	Octostim/Emosint/Minirin/Stimate/Octim							Desmopressine Ferring Cp 0,2mg Desmopressine Teva Cp 0,2mg Minirin amp 10ml i.v. 4 µg/ml Minirin spray nas 10 µg/dose Nocturna lyophilisat sub.ling. 25 µg 50µg			Minirin spray nas 5 ml (0,1 mg/mL) Minirin melt 120 mcg			Minirin			Octim (nasal spray)								Emosint and Minirin			Octostim 15mcg/ml
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17	Haemophilia A without inhibitors	FVIII concentrate	x		SHL	octocog alfa	Advate	Licensed in Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Malta, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Spain, Switzerland, Turkiye, Ukraine, UK			Advate			Advate 250, 500, 1000, 1500, 2000, 3000		Advate	Advate 500, 1000	Advate	Advate	Advate	Advate	Advate	Advate		Advate 250, 500, 1000, 1500, 2000, 3000	Advate	Advate	Advate	Advate		Advate	Advate		Advate 250, 500, 1000	Advate	Advate	Advate	Advate			Advate	Advate	Advate	Advate	Advate	Advate	Advate	Advate	Advate	Advate		Advate		Advate	Advate	Advate
18			x		EHL	rurioctocog alfa pegol	Adynovi / Adynovate	Licensed in Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Russia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkiye			Adynovi			Adynovi 500, 1000, 2000		Adynovi	Adynovi 500, 1000	Adynovi	Adynovi	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi 250, 500, 1000, 2000	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi			Adynovi 500, 1000, 2000	Adynovi	Adynovi	Adynovi				Adynovi	Adynovi	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi
19			x		SHL	lonoctocog alfa	Afstyla	Licensed in all EU countries, Switzerland, UK, Azerbaijan, Kazakhstan, Russia, Serbia, Turkiye, Uzbekistan			x	x		Afstyla 500, 1000, 2000		x	Afstyla 250, 500, 1000	x	x	Afstyla	x	x	x		Afstyla 250, 500, 1000, 1500, 2000, 3000	x	x		x		Afstyla	x		Afstyla 250, 500, 1000, 1500, 2000, 2500, 3000	x	x	x				x		x	x	x	x	x	x	x	x	x	x		x		x	x
20			x		EHL	efmoroctocog alfa	Elocta/Eloctate	All EU countries, UK, Switzerland, Russia, Turkiye, Israel, Bosnia and Herzegovina, North Macedonia, Serbia			x			Elocta 250, 500, 750, 1000, 1500, 2000, 3000	x	x	Elocta 250, 500, 750, 1000, 1500, 2000, 3000	x	x	Elocta	x	x	x		Elocta 250, 500, 750, 1000, 1500, 2000, 4000	x	x		x	x	Elocta			Elocta 250, 500, 750, 1000, 1500, 2000, 3000, 4000, 5000, 6000	x	x	x	x			x		x	x	x	x	x	x	x	x	x	x		x		x
21			x		EHL	turoctocog alfa pegol	Esperoct							Esperoct 500, 1000, 1500, 2000, 3000			Esperoct 500, 1000, 3000			Esperoct					Esperoct 500, 1000, 1500, 2000, 3000						Esperoct			Esperoct 500, 1000
22			x		EHL	damoctocog alfa pegol	Jivi	Licensed in all EU countries, B&H, Iceland, Norway, Switzerland,Turkiye, UK			Jivi 500, 1000, 2000, 3000			Jivi 500, 1000, 2000, 3000	Jivi 1000, 2000, 3000	Jivi 500, 1000	Jivi 500, 1000, 2000, 3000	x	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000, 4000	Jivi 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	x		Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000	x	Jivi 500, 1000, 2000, 3000	x		Jivi 500, 1000, 2000, 3000			Jivi 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	x				Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000, 4000	x	Jivi 1000, 2000	x			x	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000, 4000	Jivi 1000, 2000, 3000		x		x
23			x		SHL	octocog alfa	Kogenate FS												x															Kogenate 250, 500, 1000, 2000, 3000
24			x		SHL	octocog alfa	Kogenate Bayer/Helixate NexGen/Iblias
25			x		SHL	octocog alfa	Kovaltry	Licensed in all EU countries, UK, Switzerland, Norway, Israel, Iceland			Kovaltry 250, 500, 1000, 2000, 3000			Kovaltry 500, 1000, 2000, 3000		Kovaltry 500, 1000	x	Kovaltry 1000, 2000	Kovaltry 1000, 2000	Kovaltry 250, 500, 1000, 2000, 3000	x	Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 250, 500, 1000, 2000, 3000		Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 250, 1000, 2000, 3000	x	x	x	Kovaltry 1000, 2000	Kovaltry 250, 500, 1000, 2000, 3000			Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 500, 1000	Kovaltry 500, 1000, 2000, 3000	x				Kovaltry 1000	Kovaltry 250, 500, 1000, 2000, 3000	x	Kovaltry 250, 500, 1000	Kovaltry 250, 500, 100			x	x	Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 500, 1000, 2000				x
26			x		SHL	turoctocog alfa	Novoeight	Licensed in all EU countries			x			NovoEight 250, 500, 1000, 1500, 2000, 3000		x	NovoEight 250, 1000, 1500, 2000, 3000	x	x	NovoEight	x	x	x		NovoEight 250, 500, 1000, 1500, 3000	x	x		x		NovoEight			NovoEight 500, 1000	x	x	x				x		x	x	x			x	x	x	x
27			x		SHL	simoctocog alfa	Nuwiq/Vihuma						Nuwiq	Nuwiq 250, 500, 1000, 2000			Nuwiq 250, 500, 100, 2000			Nuwiq					Nuwiq 250, 500, 1000, 2000, 3000, 4000 Vihuma 250, 500, 1000, 2000, 3000, 4000						Nuwiq			Nuwiq 250, 500, 1000, 2000 Vihuma 250, 500, 1000, 2000, 2500, 3000, 4000
28			x		SHL	moroctocog alfa	Refacto AF	Licensed in Albania, Austria, Belgium, Bosnia-Hersegovina, Bulgaria, Croatia, Cyprus, Czeck Republik, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Latvia, Lithuania, Luxembourg, North Macedonia, Malta, the Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Turkiye, Ukraine, United Kingdom and Uzbekistan	x		x			Refacto AF 250, 500, 1000, 2000, 3000	x	x	Refacto AF 250, 500, 1000, 2000	x	x	Refacto AF	x	x	x		Refacto AF 250, 500, 1000, 2000, 3000	x	x	x	x	x	Refacto AF			Refacto AF 250, 500, 1000, 2000, 3000	x	x	x	x			x	x	x	x	x		x	x	x	x	x			x	x	x	x
29			x		SHL	octocog alfa	Recombinate	Licensed in Belgium, Germany, Italy, Lithuania, Netherlands						Recombinate											Recombinate 1000						Recombinate				Recombinate						Recombinate
30				x			Octanate/Octanate kons/Octanate LV						Octanate	Octanate 250, 500, 1000			Octanate 500, 1000			Octanate LV					Octanate 250, 500, 1000						Octanate			Octanate 500 SV, 1000 SV
31				x			Aafact
32				x			Amofil
33				x			Emoclot/Klott/Emowil						Emoclot				Emoclot 500, 1000														x
34				x			Beriate	Licensed in Azerbaijan, Germany, Austria, Italy, Portugal, Spain, Bulgaria, Croatia, Czechia, Hungary, Poland, Romania, Slovakia, Slovenia, Estonia, Latvia, Lithuania, Malta, Belarus, Kazakhstan, Moldova, North Macedonia, Russia, Serbia, Turkiye, Ukraine, Uzbekistan			Beriate	Beriate	Beriate			Beriate	Beriate		Beriate		Beriate				Beriate 250 IU, 500 IU, 1000 IU, 2000 IU		Beriate				Beriate	Beriate		Beriate	Beriate		Beriate	Beriate	Beriate				Beriate	Beriate	Beriate	Beriate	Beriate	Beriate	Beriate	Beriate				Beriate	Beriate		Beriate
35				x		VWF/FVIII	Immunate/Immunate Stim Plus/Immunate SD	Licensed in Albania, Austria, Belarus, Bulgaria, Croatia, Czechia, Estonia, Germany, Hungary, Italy, Kazakhstan, Latvia, Lithuania, Malta, North Macedonia, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Switzerland, Turkiye, Ukraine	Immunate		Immunate		Immunate			Immunate	Immunate		Immunate		Immunate				Immunate Stim Plus - 500 I.E., 1000 I.E. : Nach Auflösen mit 5 ml (500 I.E. Packungsgröße) oder 10 ml (1000 I.E. Packungsgröße) sterilisiertem Wasser für Injektionszwecke enthält das Produkt 100 I.E./ml (500 I.E. und 1000 I.E. Packungsgröße) an Blutgerinnungsfaktor VIII vom Menschen und 60 I.E./ml (500 I.E. und 1000 I.E. Packungsgröße) an von-Willebrand-Faktor vom Menschen.		Immunate				Immunate	Immunate		Immunate 500SV/375SV Immunate 1000SV/750SV	Immunate		Immunate	Immunate					Immunate	Immunate	Immunate	Immunate	Immunate	Immunate	Immunate			Immunate		Immunate	Immunate
36				x			Alphanate/Fanhdi																		Fanhdi 250 I.E., 500 I.E., 1000 I.E., 1500 I.E., 300 I.E. vWF, 600 I.E. vWF, 1200 I.E. vWF, 1800 I.E. vWF						Alphanate®/Fanhdi
37				x			Talate																								Talate
38				x			8Y
39				x			Factane
40				x			Haemoctin/Haemoctin Sdh																		Haemoctin 250, 500, 1000						Haemoctin
41				x			Humaclot/Humafactor-8
42				x			Koate DVI
43				x		VWF/FVIII	Voncento	Licensed in all EU countries, Switzerland, UK			Voncento			Voncento		Voncento	Voncento	Voncento	Voncento	Voncento	Voncento	Voncento	Voncento		Voncento 500/1200, 1000/2400	Voncento	Voncento		Voncento		Voncento			Voncento 250/600, 500/1200, 1000/2400	Voncento	Voncento	Voncento				Voncento		Voncento	Voncento	Voncento			Voncento	Voncento	Voncento	Voncento	Voncento				Voncento
44		VWF/FVIII concentrate		x		VWF/FVIII	Haemate-P/Humate-P/Haemate	Licensed in Austria, Azerbaijan, Belarus, Belgium, Cyprus, Czechia, Denmark, Estonia, Finland, Germany, Greece, Hungary, Croatia, Israel, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Moldova, The Netherlands, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovenia, Slovakia, Spain, Sweden, Switzerland, Turkiye, Uzbekistan			Haemate-P	Haemate-P	Haemate-P	Haemate-P 500/1200, 1000/2400			Haemate 500/1200	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P			Haemate 250/600, 500/1200, 1000/2400	Haemate-P	Haemate-P			Haemate-P	Haemate-P	Haemate-P		Haemate-P	Haemate-P	Haemate-P			Haemate-P		Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P		Haemate-P	Haemate-P		Haemate-P
45				x			Wilate/Wilnativ						Wilate	Wilate 500/500, 1000/1000																	Wilate
46				x			Optivate/Optiwate																		Optivate 250 IU, 500 IU, 1000 IU, 430 IU vWF , 860 IU vWF , 1760 IU vWF
47				x			Octafil/Octafil LV
48				x			Faktor VIII SDH INTERSERO																		Faktor VIII 250,500, 1000
49			x		UHL	efanesoctocog alfa	Altuvoct	Licensed in all EU countries, UK, Israel, Switzerland			Altuvoct			Altuvoct		Altuvoct	Altuvoct	Altuvoct	Altuvoct	Altuvoct	Altuvoct	Altuvoct	Altuvoct		Altuvoct 250, 500, 1000, 2000, 3000, 4000	Altuvoct	Altuvoct		Altuvoct	Altuvoct	Altuvoct			Altuvoct	Altuvoct	Altuvoct	Altuvoct				Altuvoct		Altuvoct	Altuvoct	Altuvoct			Altuvoct	Altuvoct	Altuvoct	Altuvoct	Altuvoct				Altuvoct
50		FVIII mimetic/ Bispecific antibody				emicizumab	Hemlibra	Licensed in all EU countries (for severe and moderate), Georgia, Israel, Albania, Turkiye, Serbia, Russia, Moldova, Belarus, Bosnia and Herzegovina, Azerbaijan, Kyrgyzstan, Ukraine, Kazakhstan, Uzbekistan, North Macedonia, Montenegro, Switzerland	x (for severe)		x	x (for severe and moderate)	x (for children / for severe and moderate)	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x (for severe and moderate)	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	Hemlibra	x	x	x	x (for severe and moderate)	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x		x	x (for severe, moderate and mild)	x	x (for severe and moderate)	x (for severe and moderate)	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	x	x (for severe and moderate)	x (severe and moderate)	x (for severe and moderate)	x		x	x	x	x (severe and moderate)	x (for severe)	x	x	x	x	x (for severe, mild and moderate)		x (for severe)	x		x (for severe and moderate)
51		anti-tissue factor pathway inhibitor (anti-TFPI)				marstacimab	HYMPAVZI	Licensed in all EU countries, Iceland and Norway. Officially commercialised in Germany.			HYMPAVZI			HYMPAVZI		HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI		HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI		HYMPAVZI			HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI				HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI			HYMPAVZI	HYMPAVZI	HYMPAVZI	HYMPAVZI
52		Desmopressin					Octostim/Emosint/Minirin/Octim																Octim								Emosint and Minirin
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54	Haemophilia A with Inhibitors	Bypassing agent	x			eptacog beta	Cevenfacta												x						Cevenfacta 1 mg, 2 mg, 5 mg						Cevenfacta			Cevenfacta 1mg, 2mg, 5mg
55			x			eptacog alfa	NovoSeven / NovoSeven RT/Coagil-VII						NovoSeven/ Coagil-VII	NovoSeven 1mg, 2mg, 5 mg indispo -> 2026			NovoSeven 1mg, 2mg, 5 mg			NovoSeven					NovoSeven 1mg, 2mg, 5 mg, 8 mg						NovoSeven			NovoSeven 1mg (50KSV), 2mg (100KSV)
56				x		activated prothrombin complex concentrate (APPC)	FEIBA	Licensed in Austria, Azerbaijan, Belarus, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Kazakhstan, Latvia, Lithuania, Malta, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkiye, UK, Ukraine			FEIBA	FEIBA	FEIBA	FEIBA 1000		FEIBA	FEIBA 500	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA		FEIBA 500, 1000	FEIBA	FEIBA		FEIBA	FEIBA	FEIBA	FEIBA		FEIBA 500V, 1000V	FEIBA		FEIBA	FEIBA			FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA		FEIBA	FEIBA	FEIBA
57		FVIII mimetic/ Bispecific antibody				emicizumab	Hemlibra	Licensed in all EU countries, Norway, Iceland, Georgia, Moldova, Ukraine, Russia, Albania, Israel, North Macedonia, Bosnia and Herzegovina, Serbia, Montenegro, Turkiye, Azerbaijan, Belarus, Kyrgyzstan, Switzerland, Kazakhstan, Uzbekistan	x		x	x	x (for children)	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	Hemlibra	x	x	x	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	x	x	x	Hemlibra	x	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		Hemlibra 30mg/ml Hemlibra 150mg/ml	x		x
58		anti-tissue factor pathway inhibitor (anti-TFPI)				concizumab	Alhemo	Licensed in all EU countries												Alhemo					Alhemo
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60	Acquired Haemophlia A (AHA)*	Bypassing agents		x		activated prothrombin complex concentrate (APPC)	FEIBA	Licensed in Austria, Azerbaijan, Belarus, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Latvia, Lithuania, Malta, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkiye, UK, Ukraine			FEIBA	FEIBA	FEIBA	FEIBA 1000		FEIBA	FEIBA 500	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA		FEIBA 500, 1000	FEIBA	FEIBA		FEIBA	FEIBA	FEIBA			FEIBA 500V, 1000V	FEIBA		FEIBA	FEIBA			FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA	FEIBA		FEIBA	FEIBA	FEIBA
61			x			rFVIIa (eptacog alfa)	NovoSeven													NovoSeven
62		Porcine FVIII Concentrate	x		SHL	rpFVIII (susoctocog alfa)	Obizur (in adults)	Licensed in Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, UK			Obizur			Obizur		Obizur	Obizur	Obizur	Obizur	Obizur	Obizur	Obizur	Obizur		Obizur 500	Obizur	Obizur	Obizur	Obizur		Obizur			Obizur	Obizur	Obizur	Obizur				Obizur	Obizur	Obizur	Obizur	Obizur			Obizur	Obizur	Obizur	Obizur					Obizur
63		Human FVIII Concentrates (only in cases of low inhibitor titer <5 BU and if bypassing agents are not available)		x		FVIII concentrate	Octanate/Octanate kons/Octanate LV						Octanate	Octanate 250, 500, 1000			Octanate 500, 1000			Octanate LV					Octanate 250, 500, 1000						Octanate			Octanate 500 SV, 1000 SV
64				x			Aafact
65				x			Amofil
66				x			Emoclot/Klott/Emowil						Emoclot				Emoclot 500, 1000														x
67				x			Beriate	Licensed in Azerbaijan, Germany, Austria, Italy, Portugal, Spain, Bulgaria, Croatia, Czechia, Hungary, Poland, Romania, Slovakia, Slovenia, Estonia, Latvia, Lithuania, Malta, Belarus, Kazakhstan, Moldova, North Macedonia, Russia, Serbia, Turkiye, Ukraine, Uzbekistan			Beriate	Beriate	Beriate			Beriate	Beriate		Beriate		Beriate				Beriate 250 IU, 500 IU, 1000 IU, 2000 IU		Beriate				Beriate	Beriate		Beriate	Beriate		Beriate	Beriate	Beriate				Beriate	Beriate	Beriate	Beriate	Beriate	Beriate	Beriate	Beriate				Beriate	Beriate		Beriate
68				x		VWF/FVIII	Immunate/Immunate SD	Licensed in Albania, Austria, Belarus, Bulgaria, Crotia, Czechia, Estonia, Germany, Hungary, Italy, Kazakhstan, Latvia, Lithuania, Malta, North Macedonia, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Switzerland, Turkiye, Urkaine	Immunate		Immunate		Immunate			Immunate	Immunate		Immunate		Immunate				Immunate Stim Plus - 500 I.E., 1000 I.E. : Nach Auflösen mit 5 ml (500 I.E. Packungsgröße) oder 10 ml (1000 I.E. Packungsgröße) sterilisiertem Wasser für Injektionszwecke enthält das Produkt 100 I.E./ml (500 I.E. und 1000 I.E. Packungsgröße) an Blutgerinnungsfaktor VIII vom Menschen und 60 I.E./ml (500 I.E. und 1000 I.E. Packungsgröße) an von-Willebrand-Faktor vom Menschen.		Immunate				Immunate	Immunate		Immunate 500SV/375SV Immunate 1000SV/750SV	Immunate		Immunate	Immunate					Immunate	Immunate	Immunate	Immunate	Immunate	Immunate	Immunate			Immunate		Immunate	Immunate
69				x			Alphanate/Fanhdi																		Fanhdi 250 I.E., 500 I.E., 1000 I.E., 1500 I.E., 300 I.E. vWF, 600 I.E. vWF, 1200 I.E. vWF, 1800 I.E. vWF						Alphanate®/Fanhdi
70				x			Talate																								Talate
71				x			8Y
72				x			Factane							Factane 1000, 2000
73				x			Haemoctin/Haemoctin Sdh																		Haemoctin 250, 500, 1000						Haemoctin
74				x			Humaclot/Humafactor-8
75				x			Koate DVI
76				x		VWF/FVIII	Voncento	Licensed in all EU countries, Switzerland, UK			Voncento			Voncento		Voncento	Voncento	Voncento	Voncento	Voncento	Voncento	Voncento	Voncento		Voncento 500/1200, 1000/2400	Voncento	Voncento		Voncento		Voncento			Voncento 250/600, 500/1200, 1000/2400	Voncento	Voncento	Voncento				Voncento		Voncento	Voncento	Voncento			Voncento	Voncento	Voncento	Voncento	Voncento				Voncento
77		VWF/FVIII concentrate		x		VWF/FVIII	Haemate-P/Humate-P	Licensed in Austria, Azerbaijan, Belarus, Belgium, Cyprus, Czechia, Denmark, Estonia, Finland, Germany, Greece, Hungary, Croatia, Israel, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Moldova, The Netherlands, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovenia, Slovakia, Spain, Sweden, Switzerland, Turkiye, Uzbekistan			Haemate-P	Haemate-P	Haemate-P	Haemate-P 500/1200, 1000/2400			Haemate 500/1200	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P			Haemate 250/600, 500/1200, 1000/2400	Haemate-P	Haemate-P			Haemate-P	Haemate-P	Haemate-P		Haemate-P	Haemate-P	Haemate-P			Haemate-P		Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P	Haemate-P		Haemate-P	Haemate-P		Haemate-P
78				x			Wilate/Wilnativ						Wilate	Wilate 500/500, 1000/1000						Wilnativ											Wilate
79				x			Optivate/Optiwate																		Optivate 250 IU, 500 IU, 1000 IU, 430 IU vWF , 860 IU vWF , 1760 IU vWF
80				x			Octafil/Octafil LV
81				x			Faktor VIII SDH INTERSERO																		Faktor VIII 250,500, 1000
82		FVIII concentrate	x		SHL	octocog alfa	Advate	Licensed in Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Kazakhstan, Latvia, Lithuania, Luxembourg, Malta, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Spain, Switzerland, Turkiye, Ukraine, UK			Advate			Advate 250, 500, 1000, 1500, 2000, 3000		Advate	Advate 500, 1000	Advate	Advate	Advate	Advate	Advate	Advate		Advate 250, 500, 1000, 1500, 2000, 3000	Advate	Advate	Advate	Advate		Advate	Advate		Advate 250, 500, 1000	Advate	Advate	Advate	Advate			Advate	Advate	Advate	Advate	Advate	Advate	Advate	Advate	Advate	Advate		Advate		Advate	Advate	Advate
83			x		EHL	rurioctocog alfa pegol	Adynovi / Adynovate	Licensed in Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Russia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkiye			Adynovi			Adynovi 500, 1000, 2000		Adynovi	Adynovi 500, 1000	Adynovi	Adynovi	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi 250, 500, 1000, 2000	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi			Adynovi 500, 1000, 2000	Adynovi	Adynovi	Adynovi				Adynovi	Adynovi	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi	Adynovi	Adynovi	Adynovi	Adynovi		Adynovi
84			x		SHL	lonoctocog alfa	Afstyla	Licensed in all EU countries, Switzerland, UK, Azerbaijan, Kazakhstan, Russia, Serbia, Turkiye, Uzbekistan			x	x		Afstyla 500, 1000, 2000		x	Afstyla 250, 500, 1000	x	x	Afstyla	x	x	x		Afstyla 250, 500, 1000, 1500, 2000, 3000	x	x		x		Afstyla	x		Afstyla 250, 500, 1000, 1500, 2000, 2500, 3000	x	x	x				x		x	x	x	x	x	x	x	x	x	x		x		x	x
85			x		EHL	efmoroctocog alfa	Elocta/Eloctate	Licensed in all EU, UK, Switzerland, Russia, Turkiye, Israel, Bosnia and Herzegovina, North Macedonia, Serbia			x			Elocta 250, 500, 750, 1000, 1500, 2000, 3000	x	x	Elocta 250, 500, 750, 1000, 1500, 2000, 3000	x	x	x	x	x	x		Elocta 250, 500, 750, 1000, 1500, 2000, 4000	x	x		x	x	Elocta			Elocta 250, 500, 750, 1000, 1500, 2000, 3000, 4000, 5000, 6000	x	x	x	x			x		x	x	x	x	x	x	x	x	x	x		x		x
86			x		EHL	turoctocog alfa pegol	Esperoct							Esperoct 500, 1000, 1500, 2000, 3000			Esperoct 500, 1000, 3000								Esperoct 500, 1000, 1500, 2000, 3000						Esperoct			Esperoct 500, 1000
87			x		EHL	damoctocog alfa pegol	Jivi	Licensed in all EU countries, Bosnia and Herzegovina, Iceland, Norway, Switzerland,Turkiye, UK			Jivi 500, 1000, 2000, 3000			Jivi 500, 1000, 2000, 3000	Jivi 1000, 2000, 3000	Jivi 500, 1000	Jivi 500, 1000, 2000, 3000	x	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000, 4000	Jivi 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	x		Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000	x	Jivi 500, 1000, 2000, 3000	x		Jivi 500, 1000, 2000, 3000			Jivi 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	x				Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000, 4000	x	Jivi 1000, 2000	x			x	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000	Jivi 500, 1000, 2000, 3000, 4000	Jivi 1000, 2000, 3000		x		x
88			x		SHL	octocog alfa	Kogenate FS												x															Kogenate 250, 500, 1000, 2000, 3000
89			x		SHL	octocog alfa	Kogenate Bayer/Helixate NexGen/Iblias
90			x		SHL	octocog alfa	Kovaltry	Licensed in all EU countries, UK, Switzerland, Norway, Israel, Iceland			Kovaltry 250, 500, 1000, 2000, 3000			Kovaltry 500, 1000, 2000, 3000		Kovaltry 500, 1000	x	Kovaltry 1000, 2000	Kovaltry 1000, 2000	Kovaltry 250, 500, 1000, 2000, 3000	x	Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 250, 500, 1000, 2000, 3000		Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 250, 1000, 2000, 3000	x	x	x	Kovaltry 1000, 2000	Kovaltry 250, 500, 1000, 2000, 3000			Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 500, 1000	Kovaltry 500, 1000, 2000, 3000	x				Kovaltry 1000	Kovaltry 250, 500, 1000, 2000, 3000	x	Kovaltry 250, 500, 1000	Kovaltry 250, 500, 100			x	x	Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 250, 500, 1000, 2000, 3000	Kovaltry 500, 1000, 2000				x
91			x		SHL	turoctocog alfa	Novoeight	Licensed in all EU countries			x			NovoEight 250, 500, 1000, 1500, 2000, 3000		x	NovoEight 250, 1000, 1500, 2000, 3000	x	x	NovoEight	x	x	x		NovoEight 250, 500, 1000, 1500, 3000	x	x		x		NovoEight			NovoEight 500, 1000	x	x	x				x		x	x	x			x	x	x	x
92			x		SHL	simoctocog alfa	Nuwiq/Vihuma						Nuwiq	Nuwiq 250, 500, 1000, 2000			Nuwiq 250, 500, 100, 2000			Nuwiq					Nuwiq 250, 500, 1000, 2000, 3000, 4000 Vihuma 250, 500, 1000, 2000, 3000, 4000						Nuwiq			Nuwiq 250, 500, 1000, 2000 Vihuma 250, 500, 1000, 2000, 2500, 3000, 4000
93			x		SHL	moroctocog alfa	Refacto AF	Licensed in Albania, Austria, Belgium, Bosnia-Hersegovina, Bulgaria, Croatia, Cyprus, Czeck Republik, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Latvia, Lithuania, Luxembourg, North Macedonia, Malta, the Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Turkiye, Ukraine, United Kingdom and Uzbekistan	x		x			Refacto AF 250, 500, 1000, 2000, 3000	x	x	Refacto AF 250, 500, 1000, 2000	x	x	Refacto AF	x	x	x		Refacto AF 250, 500, 1000, 2000, 3000	x	x	x	x	x	Refacto AF			Refacto AF 250, 500, 1000, 2000, 3000	x	x	x	x			x	x	x	x	x		x	x	x	x	x			x	x	x	x
94			x		SHL	octocog alfa	Recombinate	Licensed in Belgium, Germany, Italy, Lithuania, Netherlands						Recombinate											Recombinate 1000						Recombinate				Recombinate						Recombinate
95		Desmopressin (only in cases of low inhibitor titer <5 BU and if bypassing agents are not available)				desmopressin	Octostim/Emosint/Minirin/Octim													Minirin			Octim								Emosint and Minirin
96		FVIII mimetic/ Bispecific antibody				emicizumab	Hemlibra	Licensed in all EU countries, Norway, Iceland, Georgia, Moldova, Ukraine, Russia, Albania, Israel, North Macedonia, Bosnia and Herzegovina, Serbia, Montenegro, Turkiye, Azerbaijan, Belarus, Kyrgyzstan, Switzerland, Kazakhstan, Uzbekistan	x		x	x	x (for children)	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	Hemlibra	x	x	x	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	x	x	x	Hemlibra	x	x	Hemlibra 30mg/ml Hemlibra 60mg/0,4ml Hemlibra 105mg/0,7ml Hemlibra 150mg/ml	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		Hemlibra 30mg/ml Hemlibra 150mg/ml	x		x
97
98	* In AHA, Immunosuppressive Therapies (ISTs) - such as corticosteroids, cyclophosphamide, or rituximab - should be started ASAP to eradicate inhibitors.
99
100	Haemophilia B without inhibitors	FIX concentrate	x		EHL	eftrenonacog alfa	Alprolix	Licensed in all EU countries, UK, Switzerland,Turkiye, Israel, Bosnia and Herzegovina, Serbia, North Macedonia			x			Alprolix 250, 500, 1000, 2000, 3000	x	x	Alprolix 250, 500, 1000, 2000, 3000	x	x	Alprolix	x	x	x		Alprolix 250, 500, 1000, 2000, 3000	x	x		x	x	Alprolix			Alprolix 250, 500, 1000, 2000, 3000	x	x	x	x			x		x	x	x		x	x	x	x	x	x		x		x