DrugAge - Rodent Data
 Share
The version of the browser you are using is no longer supported. Please upgrade to a supported browser.Dismiss

 
View only
 
 
ABCDEFGHIJKLMNOPQRSTUVWXYZ
1
Compound NameSpecies
Avg/Med Lifespan Change (%)
Max Lifespan Change (%)
SynonymsStrainDosageGenderSignificant?
Reference (Note: DrugAge web site has all references; I have only transcribed a few)
2
2,4-dinitrophenolmouse7DNP
Swiss Webster
1 mg/LFemaleY
3
Acarbosemouse2211ACAUM-HET31000mg/kgdietMaleY
4
Acarbosemouse59ACAUM-HET31000mg/kgdietFemaleY
5
Acticoa powderrat11
Cocoa polyphenolic extract
Wistar-Unilever
24 mg/5 ml/kgY
6
Alpha-lipoic acidrat0
DL-thioctic acid
BN/SsNOlaHSD
1.5 g/kgMaleN
7
Aspirinmouse80UM-HET32.5g /kg foodMaleY
8
Branched-Chain Amino Acids
mouse120
BCAAs; Branched-Chain Amino Acids
B6.129S2
1.5 mg/g body weight
Y
9
Buforminrat76LIO5 mg/dayFemaleY
10
Butylated hydroxytoluenemouse16BaLB/cFemaleY
11
Butylated hydroxytoluenemouse19BaLB/cMaleY
12
C60rat90Fullerene
1.7 mg/kg of body weight
Y
13
Creatinemouse84C57BL/6J0.01FemaleY
14
Curcuminmouse3UM-HET3
300 mg/ kg of food
MaleN
15
Curcuminmouse5UM-HET3
300 mg/ kg of food
FemaleN
16
D-glucosaminemouse66C57BL/6NRj10 g/kgY
17
Echinacea purpurea rootmouse28BALB/cByJ2 mg/dayMaleY
18
Epigallocatechin-3-gallaterat13EGCGWistarMaleY
19
Epithalaminmouse31
Pineal peptide Preparation
C3H/SnNAY
20
Epithalaminrat25
Pineal peptide Preparation
NAY
21
Ethoxyquinmouse18C3H0.5% w/wMaleY
1971 https://www.ncbi.nlm.nih.gov/pubmed/4927196
22
Ethoxyquinmouse20C3H0.5% w/wFemaleY
1971 https://www.ncbi.nlm.nih.gov/pubmed/4927196
23
Ginkgo biloba extractrat17EGb 761Fischer 34450 mg/kgMaleY
24
Green tea extractmouse5UM-HET3
2000 mg/kg of food
MaleN
25
Green tea extractmouse7UM-HET3
2000 mg/kg of food
FemaleN
26
Green tea polyphenolsmouse60C57BL/6J(80 mg/lY
27
Green tea polyphenolsmouse6
Sprague-Dawley
80 mg/LMaleY
28
Icariinmouse86C57BL/6J0.06% in foodMaleY
2015 https://www.ncbi.nlm.nih.gov/pubmed/26145038
29
Icariinmouse43C57BL/6J0.02% in foodMaleY
2015 https://www.ncbi.nlm.nih.gov/pubmed/26145038
30
Ivabradinemouse6C57BL/6J50 mg/kg/dayMaleY
31
L-deprenylmouse431SelegilineB6CBAF1
0.25 mg/kg 3x/week
FemaleN
32
L-deprenylmouse315SelegilineB6D2F1
0.25 mg/kg 3x/week
MaleN
33
L-deprenylmouse78SelegilineB6CBAF1
0.25 mg/kg 3x/week
MaleN
34
L-deprenylmouse0-1SelegilineB6D2F1
0.25 mg/kg 3x/week
FemaleN
35
L-deprenylrat1717SelegilineFischer 3440.0025Y
36
L-deprenylrat61SelegilineF344/DuCrj
0.5 mg/kg. 3 times a week
MaleY
37
L-deprenylrat7SelegilineF344/DuCrj
0.25 mg/kg. 3 times a week
FemaleY
38
L-deprenylrat8SelegilineF344/DuCrj
0.25 mg/kg. 3 times a week
MaleY
39
L-deprenylrat15SelegilineF344/DuCrj
0.5 mg/kg. 3 times a week
MaleY
40
L-Glu-L-Trp dipeptiderat010
5 µg/rat. 5 times a week
FemaleY
41
Marine collagen peptidesrat1113MCPs
Sprague-Dawley
0.09Y
42
Medium-chain triglyceride oilmouse-1UM-HET3
60000mg/kg of diet
MaleN
43
Medium-chain triglyceride oilmouse2UM-HET3
60000mg/kg of diet
FemaleN
44
Melatoninmouse58CBA20mg/lFemaleY
45
Melatoninmouse18BALB/cNAFemaleY
46
Metforminmouse6C57BL/6J0.001Y
47
Metforminrat22Fischer 344300 mg/kg/dayN
48
Methylene bluemouse06MBUM-HET327mg/kg dietFemaleY
49
Metoprololmouse10C3B6F11.1 g/kg dietMaleY
50
N-acetyl-L-cysteinemouse2445NACUM-HET310 g/L of waterMaleY
51
N-tert-butyl-alpha-phenylnitrone
mouse45
PBN; alpha phenyl-N-tert butyl nitrone
C57BL/6J
0.25 mg/ml of water
MaleY
52
Nebivololmouse6C3B6F10.27 g/kg dietMaleY
53
Nordihydroguaiaretic acidmouse120NDGAUM-HET32.5 g/kg foodMaleY
54
Nordihydroguaiaretic acidmouse
Mesonordihydroguaiaretic acid
B6C3F1æ1.5 g/kg dietMaleN
55
Nordihydroguaiaretic acidmouse
Mesonordihydroguaiaretic acid
B6C3F1æ2.5 g/kg dietMaleN
56
Nordihydroguaiaretic acidmouse
Mesonordihydroguaiaretic acid
B6C3F1æ4.5 g/kg dietMaleN
57
Nordihydroguaiaretic acidmouse12
Mesonordihydroguaiaretic acid
B6C3F1æ3.5 g/kg dietMaleY
58
Olive Oilrat18Y
59
Oxaloacetatemouse3
Oxaloacetic acid
UM-HET3
2200 mg/Kg of food
FemaleN
60
Oxaloacetatemouse4
Oxaloacetic acid
UM-HET3
2200 mg/Kg of food
MaleN
61
Phenforminmouse2126C3H/Sn
2 mg, 5 times a week
FemaleY
62
Polypeptide Bovine Thymus extract
mouse2811C3H/Sn0.5 mgFemaleY
1982 https://www.ncbi.nlm.nih.gov/pubmed/6752596
63
Polypeptide Pineal extractmouse3114PPEC3H/Sn0.5 mgFemaleY
1982 https://www.ncbi.nlm.nih.gov/pubmed/6752596
64
Polypeptide Pineal extractrat25PPE
0.5 mg, 5 times a week
FemaleY
65
Polyphenolsmouse6C57BL/6JMaleY
66
Rapamycinmouse1314
Hybrid of CB6F1(F)& C3D2F1(M)
2.24 mg/kg/dayFemaleY
67
Rapamycinmouse109129/Sv1.5 mg/kgFemaleY
68
RapamycinmouseC57BL/6JMaleY
69
RapamycinmouseC57BL/6J4 mg/kgMaleY
70
Rapamycinmouse0UM-HET3
42 mg of drug per kg of food
MaleY
71
Rapamycinmouse0UM-HET3
42 mg of drug per kg of food
FemaleY
72
Rapamycinmouse5C57BL/6æ14 ppmFemaleY
73
Rapamycinmouse11C57BL/6J14 ppmMaleY
74
Rapamycinmouse16C57BL/6J14 ppmFemaleY
75
Resveratrolmouse3UM-HET3
300 mg/ kg of food
MaleN
76
Resveratrolmouse5UM-HET3
300 mg/ kg of food
FemaleN
77
Royal Jellymouse24C3H/HeJ
500 ppm ad libitum in diet
MaleY
2003 https://www.ncbi.nlm.nih.gov/pubmed/12954483
78
Sodium boratemouse-3C57BL/6J0.1 mMMaleN
79
Sodium boratemouse1C57BL/6J0.5mMMaleN
80
SperminemouseSPMCrj:CD-13 mg.kg-1.dose-1FemaleY
81
SRT1720mouse90C57BL/6J
100 mg/kg body weight
Y
82
Tetrahydrocurcuminmouse127C57BL/6J0.002Y
83
Tetrahydrocurcuminmouse12
Sprague-Dawley
0.002MaleY
84
Thyroxinrat-4T4Wistar
0.5 µg/g bodyweight
FemaleY
85
Thyroxinrat7T4Wistar
0.5 µg/g bodyweight
MaleY
86
Thyroxinrat8T4Wistar
1 µg/g bodyweight
FemaleY
87
Thyroxinrat11T4Wistar
2 µg/g bodyweight
MaleY
88
Thyroxinrat12T4Wistar
2 µg/g bodyweight
FemaleY
89
Thyroxinrat16T4Wistar
1 µg/g bodyweight
MaleY
90
VI-28mouse7C57BL/6J0.005FemaleN
2010 https://www.ncbi.nlm.nih.gov/pubmed/20370440
91
VI-28mouse9C57BL/6J0.0005FemaleY
2010 https://www.ncbi.nlm.nih.gov/pubmed/20370440
92
VI-28mouse14C57BL/6J0.005MaleY
2010 https://www.ncbi.nlm.nih.gov/pubmed/20370440
93
VI-28mouse14C57BL/6J0.0005MaleY
2010 https://www.ncbi.nlm.nih.gov/pubmed/20370440
94
Vitamin Emouse15
Alpha-tocopherol
C57BL/6J550 mg/kgY
2008 https://www.ncbi.nlm.nih.gov/pubmed/18257658
95
96
97
98
99
100
Loading...
 
 
 
Sheet1