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curation_datecohortage_minage_maxage_unitsnumber_subjectstissue_typetissue_type_term_idmethodresponse_componentis_modelresponse_behavior_typeresponse_behaviorcomparisonbaseline_time_eventtime_pointtime_point_unitsexposure_materialexposure_material_idexposure_processdisease_namedisease_stagepublication_reference_idpublication_datepublication_reference_urlsignature_sourcecommentscurator_comments
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subjectcell_subset(will be added by processing script)pathogen
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evidencelabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabellabelurllabellabellabel
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rolebackgroundobservedobservedobservedobservedobservedbackgroundtissuebackground(will be added by processing script)backgroundbackgroundmeasuredbackgroundbackgroundobservedobservedbackgroundpathogenbackgroundbackgroundobservedbackgroundbackgroundreferencebackgroundbackgroundobserved
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mime_type
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numeric_units
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Descriptioncuration date YYYY-MM-DDA short description of the population where the immune signature is measured.age_min - age of youngest subject including both cases and controlsage_max - age of oldest subject including both case and controlsage unitsnumber of subjects - count of case plus control subjects used in the measurement.tissue typetissue (Cell Ontology)method - primary experimental method used to measure the responseresponse componentsignature was derived from a computational modelresponse behavior typeresponse behavior (direction, correlation type etc.)Description of the comparison which gives rise to the response behavior reported in the immune signature.baseline time eventtime point relative to baseline event at which response was measuredtime point unitsexposure material (NCBI pathogen name)exposure material (NCBI taxid)exposure process - method by which immune exposure  occurreddisease namedisease stage - reported disease stage(s) of affected subjectsPublication identifier (PMID).Print publication date or posted date.Publication URLIdentifier of the publication section where the signature is reported.Curator comments to accompany the released immune signature.Curator comments directed to the HIPC Dashboard team.
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vocabulary, separatorYYYY-MM-DDfree textnumbernumberchoose from listnumberFree text. Multiple entries must be separated with a semicolonChoose from list or lookup Cell Ontology code. Multiple entries must be separated by a semicolon, e.g. CL:0000576 (monocyte); CL:0000235 (macrophage). Just the code is also acceptable, e.g. CL:0000576Choose from list. Only one entry expected. You can add new methods.Gene or protein symbols can be separted with commas, spaces, or semicolons. Cell types or other names must be separated using semicolons.Y/NChoose from list. Only one entry allowed. Choose from list. Only one entry allowed. Add new behaviors if required.Free text. Use "vs" rather than a dash to separate comparison terms (A vs B). When a reported response behavior with identical response components has been observed across multiple comparisons, they may be combined in one row; separate individual comparison entries with semicolons (A vs C; B vs C).Free textNumber or free textChoose from list. Lowercase onlyfree textChoose from list or use format ncbi_taxid:2697049Choose from list. Enter new process if needed.free textfree textnumberYYYY-MM-DDURLfree textfree text
free text
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Additional information for curatorsDate curation completedConstruct using relevant characteristics of the studied population(s), as reported in the publication. Indicate if the result is relevant to a subgroup of the overall cohort, e.g.
• subjects suffering adverse events
• particular threshold levels of antibody titer
• based on a receiving a particular treatment

Example: “COVID-19 patients and healthy controls (Hong Kong, China)”, “Vaccine non-responders with mild/moderate disease (Atlanta, Georgia)”.		Include both case/affected and control subjectsInclude both case/affected and control subjectshours, days, months, yearsOften differs by signature within a publication. If number of subjects for a particular signature is not clear in text, use total for cohort.As reported. The parent tissue of the response components. For cell-type results, the tissue is often PBMCs, but can also be a specific base cell type. For gene expression, the tissue might be a specific base cell typeCell Ontology IDs for tissues in column “tissue_type”. If there is no matching cell type in the pulldown list, the curator can try to look up a matching term in the Cell Ontology. If there is no appropriate Cell Ontology term, UBERON codes can also be used.The primary experimental method used to measure the response, e.g. RNA-seq, CyTOF, CITE-seq. The entities whose response is being measured. Please copy symbols and names exactly as reported in the publication - except spell out greek letters. For cell types, this includes all markers.
Examples for a signature with three cell types:
T cells CD3+/CD4+/Ki67+; T cells CD3+/CD8+/Ki67+
CD86+ myeloid dendritic cell (DC); CD86+ monocyte		Were the response components chosen using a classification or other model-building strategy?The type of change being measured, e.g. gene expression, cell-type frequency.Common values in the pulldown list:
- up, down
- positively correlated, negatively correlated, correlated
- positively predictive, negatively predictive, predictive		Comparisons are typically between two groups, or may reflect a correlation of the response component with some other measured variable. Only report significant results. Examples:
- severe COVID-19 cases (N=24) vs healthy (N=28)
- moderate COVID-19 cases vs healthy; severe COVID-19 cases vs healthy
- interferon-stimulated genes in COVID-19 vs healthy
- bacterial DNA levels across COVID-19 and healthy subjects

If known, include the number of subjects in each comparison group using (N=<num>) notation. Include time comparison if relevant, e.g. 7d vs 0d, where the times are relative to the baseline reference event time (0d). Times before baseline event can be entered as negative numbers, e.g. days before vaccination (7d vs -1d).
**Please be concise.**		The reference event from which the time of the experimental response is measured, e.g. hospital admission, onset of symptomsTime point when response was measured, e.g. “7”, “various”, “0 to 8”days, months etc.Enter the pathogen underlying the immune exposure as reported in the publication or use the NCBI Taxonomy term nameNCBI Taxonomy ID of pathogen causing diseaseMethod by which exposure to pathogen occurredE.g. COVID-19Reported disease stage(s) of affected subjects in all comparisons entered in row (not including control subjects). We will not attempt to match these directly with the comparisons. Examples include moderate, severe, ICU etc. Pooled can also be added.
Enter the PMID for the article curated, e.g. 32788292. If no PMID is available (i.e., because the publication is not listed in Pubmed), leave empty.Partial dates are OK, e.g. YYYY-MM or YYYYUse when no PMID is available. Otherwise leave empty.Enter the figure number, table number, section heading or number, etc., where the signature was found within the source publication. Multiple entries, separated by semicolons, are allowed. This may be necessary if the signature is reported in multiple locations, e.g., in a table within the main article as well as in the supplementary materials.Additional details related to the signature, not captured in other fields, that the curator deems necessary context for properly parsing the signature. This text will be available in the HIPC Dashboard, as part of the immune signature.

Limit of 250 characters		Questions or notes for further examination from the curator. Will not appear in Dashboard.
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2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 32Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)Q-PCRSARS-CoV-2Ngene expressiondownchildren with allergic asthma vs healthy nonsensitized controlsinfectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig. 1A
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2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 10Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)ELISAACE2Ncytokine/protein leveldownchildren with allergic asthma with and without IL-13 treatmentinfectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig. 1D
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2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 10Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)ELISAACE2Ncytokine/protein leveldownhealthy nonsensitized controls with and without IL-13 treatmentinfectionSevere acute respiratory syndrome coronavirus 2ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig 1F
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bulk2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 9Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seqCST1,SERPINB4,VSIG2,CEACAM5,CD55,OBFC1,ST3GAL4,PTHLH,SPDEF,SLC39A8,LOXL4,LRRC31,CDC42EP5,SERPINB2,CTSC,NABP1,ANXA3,RAI14,SERPINB6,SLC17A5,SLC26A4,HS3ST1,SLC9A3,SDCBP2,LRRC8D,SYNGR2,TMC1,BCL2L15,ELOVL5,POSTN,NEK6,FAM177A1,CDH26,ADAM28,C1QTNF1,GCNT2,LBH,CAV1,SLC5A8,DHRS7,GNE,PPARG,FCGBP,SSFA2,TRPV6,GALNT5,CCBL1,HPGD,ARNTL2,GSN,MME,B3GNT6,C1orf64,ATOH8,SLC6A14,SLC5A5,MGAT1,RUSC1,ID3,SNCA,ATP13A5,PYCR1,PARM1,SLC12A2,GALNT7,FOLH1,SCIN,GCNT3,DPP4,CST3,TIMP1,GJB2,MAOA,DLG1,TSPAN13,ST6GAL1,CYTIP,TCN1,IL1A,CD36,DUOX2,TSPAN8,C3orf52,BCAT1,WSB2,CD274,SDC2,VAT1,ADRA2A,TMPRSS2,CMYA5,PIP,SGK1,PTPRQ,PPP1R14A,KRT16,KLF4,CLASP1,UAP1,TENM2,KDELR3,FZD5,TRIM16,ADAM9,TNFSF10,PIK3C2G,CST2,MREG,UTP20,USP54,MFSD4,ME1,PROCR,PRKCH,FAM46B,PLS1,FAM109B,SLC9B2,CPQ,PTAFR,TLR4,RNF39,KCNK3,SLC31A1,ITLN1,ALOX15,ALPL,GALNT6,PDZK1IP1,S100P,AIM1,CA2,TRABD2A,MAP1B,BEAN1,CST4,PITRM1,CD44,SH2D1B,CD9,MAPKAPK3,FA2H,CST5,CAMK1D,FAM177B,KANK3,KCNK6,SH3RF2,ABHD17C,LIPH,BLVRB,CDH6,PYROXD2,CD320,KCND2,HAS2,FAM26E,DEFB1,ERMN,KRT23,PLD2,AHCYL2,LGR5,LRRC8A,GPX2,ARL4C,KCNE3,PFKP,SERPINB11,DEAF1,SNPH,MMP12,PDLIM4,PLA2R1,PLEKHG6,ADAMTSL3,FAM134B,ANKRD22,CISH,CDC42EP2,MARVELD3,CREB3L1,MMP28,CBR3,RAET1L,PSTPIP1,GNPNAT1,FAM26D,BDNF,NTRK1,CCDC68,KRT6A,TRIM16L,CLCA1,PCSK6,PPP1R16B,FGF13,IL20RB,TESK1,SLC16A9,SLC5A1,NIPA1,ADA,HSD3B1,KCNJ15,CYP27B1,NFE2,DUOXA2,FOXA3,TMEM171,CLLU1OS,MAFF,OSBPL7,COL23A1,MMP19,THBD,SUSD2,DOK1,TNIP3,EMILIN2,ARHGEF37,CRAT,CPA4,HAS3,ANXA6,TRPM4,EPHX4,DKK3,ATRNL1,DAB2,TMEM92,FBP1,NPDC1,HPDL,DUSP7,TTYH2,KIF1C,HOMER2,MYO1C,SLC7A4,GALNT10,FER1L6,CH25H,ALOX15B,RASL11B,VSIG1,LTBR,SPRR3,TANGO6,KAZALD1,HRH1,SLC30A4,IMPDH1,STAC,F3,SYNC,GOLGA7B,RELB,CEACAM21,CDK18,DISP1,BICD1,TFPI2,ANGEL1,C8orf4,TMBIM1,AMOT,TPK1,ANO1,PHLDA2,SERPINB13,HMHA1,IL36RN,VCAM1,FAM83D,ADAM8,PCBP4,EIF4E3,CLDN5,SCARB1,LGALS4,SPHK1,SHROOM1,KCNMB4,ZBED2,HMGCS2,RUNX2,RXFP1,PHLDB2,TMC8,PPP2R5B,MMP7,DGKA,DHX35,NTN4,MAP1LC3B2,TREML2,ADCY6,PPM1M,TRPM6,SUGCT,SLC27A4,FAM198A,PFKFB4,IL19,TRNP1,SIDT1,KLK1,CAPN14,SLC5A3,FLG,CCDC9,DQX1,ULBP2,PCED1B,SLC2A6,SLC7A11,ZNF331,CSTA,SLC12A8,GSTM3,MMP1,OTUB2,KLHDC7A,ICAM2,SERPINB10,FJX1,FKBP1B,NNMT,RHOH,SLC29A4,SLC5A12,EDNRA,CCL26,ST18,DNAJC12,NOTCH4,TM4SF1,CPNE4,CXCL14,STON1,CCND2,ZNF467,ATP7B,NAGPA,TNIK,FBXL6,SOX9,SEMA3B,SLCO4A1,LOXL3,SH3BP1,PTCHD4,LRP3,HMCN1,IER3,GCNT4,SLC35G1,SELP,SYNM,MYO16,MEGF6,DAPK2,SGSH,TNC,NAV1,PDCD1LG2,HKDC1,OSBPL5,BVES,PLEKHO1,PRB2,MLKL,KRT75,VWF,LYZ,PSG5,AGPAT9,CABLES2,TPCN2,EHD3,NALCN,PLCB4,PTPRN2,SGTB,PRKCQ,LHFP,NPPC,PGF,ATP12A,TCAF2,PANX2,NTRK2,ALDH1A3,GJB1,PADI3,GDPGP1,SLC7A1,FETUB,IGSF3,TNFRSF9,ADCY4,IL12RB2,SLC26A11,SECTM1,GJB6,ARHGAP40,ANKRD29,OGDHL,CYP2C9,TG,NRBP2,BCL2A1,FIGN,IL1RL1,HAAO,PRB1,APOE,FAM65A,LBX2,UGT2A1,RTN4R,CHODL,ADAP2,SH3TC1,FAM101A,THBS1,FZD9,GADD45G,ALDOB,FAM222A,CPB1,ZPLD1,HS3ST2,TMEM106A,RASD2,KCTD14,FAIM2,FZD10,UAP1L1,GPR68,TAT,IL18R1,CDH4,GALNT4,DIO2,HEG1,IL17RB,HYAL1,NDRG4,PNPLA7,ELOVL7,MTCL1,RGS13,HSD11B2,CERCAM,IGIP,SMTN,HTT,HSD17B14,MAP3K14,ZMAT4,NACAD,SOCS1,RPTN,KLF2,HS3ST4,NOS2,C2orf88,ANO7,FAM132A,ESAM,ITGB6,MARCH9,TSPAN7,C6orf15,C10orf55,COL27A1,GPR157,FAM101B,GGT1,HSD11B1,HSD17B6,NEDD9,RASAL1,CALD1,HSPB8,SLC25A21,CDA,AZGP1,FOSL1,SSC4D,CLCN5,KLF8,PELI3,ANGPTL4,SMOX,SLC15A1,MROH6,PRR4,MGRN1,LRRC17,LRRC75B,KLK7,FOXD1,SULF2,PTPN22,SLC24A3,PPP1R3C,SULF1,TBXAS1,ARHGAP10,CCK,B4GALNT3,SLC4A3,RHD,GPRASP1,POLE,QPRT,DGKD,ECHDC3,ZNF365,GPR146,FAM150A,ZNF503,WFDC5,S100A3,EGFL7,ROR2,KCNJ5,COL5A2,AADAC,ELOVL4,FAM3BNgene expressiondifferentially expressedGenes up-regulated by IL-13 stimulation after infection in allergic asthmainfectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig. 2BTable E1, sheet 1
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bulk2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 9Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seqSCGB3A1,SCGB1A1,SYT5,CCNO,CYP2F1,CD19,WDR54,TMEM231,SUSD4,CCDC80,BBOX1,MYCL,CCP110,INHBB,TMEM45A,SAMD15,PROM1,SCG3,LRRC23,DNALI1,C15orf26,CCDC74A,ODC1,SAXO2,HES6,C1orf168,CC2D2A,PTGFR,UBXN11,PTH2R,KIAA1211L,C22orf15,CDC20B,TSGA10,C9orf116,AZU1,SPEF1,C11orf49,CROCC2,BPIFA1,KRT15,IDH2,WDR38,CCDC33,FAM92B,NPHP1,GAS7,C1orf194,ERICH5,LDLRAD1,CCDC42B,FBXO15,RAB36,HSPBP1,CD38,MCIDAS,SAMHD1,CFAP43,LRRC46,TTC26,ZMYND10,SPATA18,RSPH9,TEKT2,LRRC10B,RUVBL1,CXXC4,CYP39A1,CCDC65,C9orf9,WDR63,BAIAP3,LRRC48,ARMC4,CCDC113,RUVBL2,STAR,DNAAF1,NEK10,RAB37,SLC51B,ROPN1L,DOC2A,DNAI1,STK33,EVL,C11orf70,TUBB4B,GRAMD2,PNMA1,FAM181A,ODF3B,MUC12,GLUL,IQCD,CFAP45,HYDIN,CCDC78,DRC1,WDR49,C2orf50,PSIP1,TCTEX1D4,ERCC1,ENO4,TTC30A,ENKUR,SMIM6,IFT172,P4HTM,VWA3B,TMEM212,ANKRD32,CCDC176,NBEA,SPAG17,PRKAR2B,C7orf57,TUBA4B,CCDC17,RSPH1,VNN2,MAP3K19,PDK4,DNAH3,EFHC1,RSPH4A,RIBC2,FBXW9,RIBC1,GAS2L2,CCDC170,CYP4X1,FAM183A,SPAG8,EFCAB1,DNAH12,TCTN1,GGT7,TMEM190,PHTF1,CAPS,C11orf16,MDH1B,FGFR3,CFAP221,TTC16,LRRIQ1,GLB1L,CEP41,C10orf107,MNS1,MKX,CFAP52,KIF27,C6orf118,CCDC114,SPATA17,C5orf49,AK8,LRRC49,WDR78,TNNC2,AKAP14,CASC1,MORN3,CAPSL,C9orf171,KIF19,ANKMY1,TTC29,APOBEC4,RFX3,IFT57,TNFAIP8L1,IQCG,USP13,TNNT3,RERG,ARMC3,B9D2,OSCP1,NEK2,KIF9,ACSS1,EFHC2,B9D1,ADGB,LXN,AGBL2,MORN5,CEP120,C5AR1,C11orf88,PPIL6,TTLL10,CCDC146,CDHR4,EFHB,FOXJ1,FAM46C,SPEF2,DNAAF3,LRRC71,C2orf70,RPGR,ZMYND12,C20orf85,TTC25,FAM81B,KIAA1407,TCTEX1D1,RPGRIP1L,GPR162,C9orf24,KLHDC9,STOX1,AK7,TLCD1,FAM86B1,C1orf87,M1AP,CATIP,TRIM55,NR5A2,SNTN,CCDC74B,HHLA2,C1orf158,DNAH6,TTLL9,TTC21A,DYNLRB2,ZBBX,C12orf75,CSPP1,AK9,IFT22,DNAH9,HIST3H2BB,PKIG,TTC30B,PLK4,WDR34,DYRK3,CCDC151,CNIH2,PIH1D3,CERKL,SPAG6,IFT81,C4orf47,GAS8,CLMN,SPATA4,THNSL1,C1orf189,RSPH14,ABCC4,CFAP44,C1orf228,ULK4,LRWD1,C16orf71,TPPP3,DAW1,BSCL2,DYNC2H1,CFAP57,MYB,TSNAXIP1,DERL3,ACSS3,FAM216B,CLU,CFAP70,CDHR3,CCDC89,NIPSNAP3B,APH1B,CDK20,TEX9,ZNF688,TMC5,TNFAIP8L3,EFCAB10,ELN,KIAA0895,DZIP1L,C21orf58,PHOSPHO2,DEPTOR,IQCH,ST8SIA4,DNAL4,FILIP1,KIAA2012,DNAI2,DEGS2,ZCWPW1,PROS1,CFAP36,LRRC6,STEAP4,CLDN3,IFT46,KLK11,TEKT1,C11orf74,METTL7A,SLC22A4,CFAP58,LCA5L,MAP6,HLA-DOA,TTC12,DENND6B,GK,TMEM232,KIAA1257,PPP1R32,RABL2A,DNAL1,CCDC18,KATNAL2,STOML3,IL5RA,CFAP20,MORN2,CP,PPP1R42,MARCH10,CFAP61,STMND1,C14orf79,YPEL1,PPOX,MROH9,MAATS1,ANKRD54,CCDC60,LRRC18,CFAP69,C3orf67,SPTSSB,SPSB2,LRRC56,SPATA7,CFAP47,WRAP53,ARL6,CCDC13,C10orf67,C9orf72,PIFO,CCDC39,BAALC,ACBD7,NME7,TMEM67,SLC25A14,DTHD1,MLF1,BBS12,KIFAP3,LEKR1,CBY1,C16orf89,CD164L2,TGFBR3,IQUB,LRGUK,C14orf142,LMO2,KNDC1,RP1,IFT88,MYCBPAP,CNTF,SRD5A2,PCM1,SPATA6L,MAD2L1,C9orf117,HIST1H2BC,DZIP3,AQP3,FAM229B,RRAD,CEP95,FAM179A,C2orf73,CCDC108,CFAP53,WDR35,TTC5,DPCD,FAM166B,PIH1D2,NHLRC4,DNAH10,ANXA10,SPA17,PPP1R16A,CDNF,CCDC173,UBXN10,NME9,BEND5,CCDC181,MAK,CCDC121,SPON2,HYLS1,RASGEF1B,DMD,FHAD1,CETN2,DYDC2,KCNH3,CCDC34,LRRC34,EFCAB11,KIF3A,CFAP46,TMCO5A,MOK,TCEAL1,GALNS,LMO4,KCNRG,SCLT1,RABL2B,FANK1,AKNA,DYDC1,NF1,SMPD2,OMG,NME5,RIIAD1,CWH43,SCGB2A1,PHF7,FAM92A1,C16orf93,ABCA6,IQCK,LRTOMT,AKR1C2,CCDC37,TCTE1,MT1E,LRRC27,CDS1,EFCAB12,NUP62CL,COCH,ANLN,MS4A8,CCDC69,LRRC61,CCDC138,DNAH7,ELK3,ZDHHC1,IGFBP6,FAM65B,WDPCP,CEP97,GSTA1,KLHL6,LRMP,CCDC153,TUBA1A,ECT2L,KLK14,RNF32,IFT52,ODF2L,IFT27,CEP128,HACD4,NAT14,ACSL5,HIST4H4,PLCH1,KCNE1,BRCA1,LRP2BP,CHI3L1,C1R,DRC7,TNFRSF19,PACRG,AKR1C1,CLUAP1,BPIFB2,WDR90,GSTA4,IFT74,ARHGAP18,CDT1,CEP83,CEP78,DCDC1,ZNF474,DNAH5,STPG1,ARMC9,GSTA3,CRISP2,CYP4F3,CCDC30,TNFRSF11B,CDC20,CALB2,ERICH3,BMP15,NUDC,E2F7,DDO,ALDH3B1,COPRS,TMPRSS3,ANKRD42,SLC24A1,SCNN1G,LEF1,LZTFL1,B3GNT5,C11orf65,ZNF214,IL33,PLEK,C1orf141,ADAM32,CAPS2,DLEC1,KLK12,PEX12,CFAP54,NEK11,BUB1,LTF,C1orf110,CHST9,ZC2HC1C,ITGB2,SMYD2,LRRC74B,LRRCC1,TSPAN19,GLIPR2,FBXO36,COL21A1,CFAP74,EFCAB7,LMNTD1,MYLK,BZRAP1,IFT43,FAM81A,STIL,SSBP4,C5orf45,MEIG1,TEKT4,ABCC6,BST1,PLA1A,BMPR1B,THRA,SLAIN2,TMEM107,MX2,SPAG16,MCTP1,MAP7D2,GRAMD1C,ANKRD66,CNTD1,PLEKHG7,TENM4,SPATS1,FAM182B,HIST1H2BJ,EFCAB6,CES4A,PLIN5,SPATA6,FRMPD2,TULP3,ASTN2,GUCA1A,FAM161A,MAPK15,CNGA4,IK,WDR93,CDK1,RFX2,CD4,WDR66,ODF2,ERICH6,ZNF273,MRLN,C12orf74,MB,IQCB1,PNLDC1,WDR19,ZNF487,PIM2,MAP1A,MOBP,C20orf195,TTC21B,MPHOSPH9,MIPEP,SFTPD,IFT122,PSENEN,ARMC2,CCDC96,FAIM,KIF24,CENPK,IRAK1BP1,NUF2,KIF6,C11orf71,C9orf135,FIBIN,TEX26,DCDC2B,DNAH2,PACRGL,STXBP6,DYNC2LI1,BBS9,DZIP1,SYT8,ABHD12B,HRK,TCTEX1D2,LKAAEAR1,RGS22,ZFP3,FOXP2,FBLN2,RARRES1,TBC1D8,TRAF3IP1,CLDN8,TRIT1,TTC23L,DIO1,C11orf63,OIP5,MYBL1,C11orf85,ARHGEF4,CCDC40,AGBL4,ORC1,LCA5,HIST1H3H,CHRNA9,SLC38A4,DNAJB13,C20orf96,RHEBL1,CATSPERD,HLA-DQA1,MCMDC2,PECR,IL3RA,ATG9B,C21orf59,SMKR1,CHL1,ZSCAN1,SPTBN4,FAM179B,PRR29,ERICH2,HLA-DPB1,CTXN1,ANKRD37,LAG3,ZNF627,ESM1,MTFR2,MESP1,ADH6,WDR92,CLGN,FAM221A,RBKS,GPR135,CA8,MKS1,ADPRHL1,FSD1L,GJB7,BCO2,TRIP13,RGS17,MAP9,RHPN1,MAPRE3,PRKCE,DALRD3,FHL1,LRRC43,RPL39L,MDM1,ENKD1,HIST3H2A,PRDM8,UNC119B,C17orf97,RSPH10B2,SCNN1B,ARL3,FRY,ABLIM2,NPR2,ANKFN1,CYP4V2,EFCAB2,ADGRE5,AQP7,VWA7,IP6K3,LRRC73,ZNF608,NRG2,CCDC81,WFDC6,WBSCR28,ZNF440,STX2,OCA2,ZBTB18,IFT140,HMGN5,FAM47E,BBS4,IFT80,RAD9A,HLA-DPA1,TCF7,HRASLS2,SLIT1,DEPDC1,TCP11,CLDN9,HIST1H1C,C8orf48,ASF1B,STK36,ADAMTS8,GPM6B,MAPK10,MORN1,C6orf163,ARHGAP24,ALMS1,UFC1,FAM227A,GATM,DLGAP5,CCDC171,STAG3,GLB1L2,ZNF239,NPM2,CEP19,VWA3A,FAM175A,SHISA2,USP51,SETD6,PDE6B,UBE3D,ZNF396,PPP4R4,HIST1H4B,PTGER2,FAM184A,C4orf22,MRPS31,KLHL13,RASAL3,HBB,NCBP2L,REEP1,DCDC2,IPO11,NSUN7,C22orf23,RAD52,ZNF486,KIF20A,FAM228B,SPAG5,ZNF788,POLI,CCDC148,VRK1,ALS2CR12,PSMC3IP,XK,GNA14,CCNA1,MTL5,RFX8,TOP2A,NEK5,SGOL2,MUC16,SPATA33,KHDRBS3,ZFP37,SVOPL,MT3,TMEM150C,MUC15,MFSD6L,HS3ST6,WBSCR27,ARHGAP4,ALG1L,MYCBP,CYP4F12,RIMKLB,APOBEC3B,IRF2BPL,CEP162,PLEKHB1,SLFN13,COL4A4,TRMT10A,DPYSL2,FTO,RSG1,NGEF,RASL11A,PLAC8,DUSP18,CMPK2,C12orf60,ROPN1B,NAT1,LRRIQ3,TLL1,MAPK8IP1,CRIP1,TMEM213,KCNK15,LY6H,DYX1C1,STXBP4,C8orf44,NR2F1,SYTL3,TGM1,TIMP4,KIAA2022,POLR2I,CCNB2,IDNK,CIITA,DNER,WDR60,CTGF,DSCAML1,HEY1,FAM104B,FBLN5,CCDC157,CHRNA1,C8orf34,CENPU,PRR18,C5,TP73,GNMT,EPPIN,DTX3,MACROD2,AXIN2,TIGD4,CNNM2,CCDC67,MT1F,PAM16,GPC3,HLA-DQB2,HNF1B,TXLNB,SDK1,GIMAP2,FBXO11,PAQR5,HOGA1,CKAP2L,TBC1D31,SGOL1,CCL15,ABCC2,SLC28A2,ASB9,NLRC3,SPATA24,ZNF599,PRR7,MEP1A,MYLK3,IMPG2,FUZ,ALDH3A1,TSLP,KLHL15,CLCNKB,WRB,UFSP1,ANPEP,CDCA3,FAM188B,PHGDH,ACAP1,C6orf165,VNN3,CNTD2,NUMBL,ACKR4,IFITM10,BTG4,CDC25C,CCDC122,NWD1,C1orf233,CNTN1,AOX1,XKRX,NLRP1,AQP5,AKAP3,FAXDC2,SYNE1,LDLRAD4,APITD1,NPW,LPAR3,HIST1H4D,ZNF300,IFIT1,RASA3,ARHGEF33,PFN4,ERCC6L,SLC39A2,CDKL2,ZNF784,RARRES2,CCDC66,SCARF2,RAPGEFL1,WNT16,FSIP1,RAD51AP1,EEPD1,TNFSF15,DNAH11,KLK13,SNX29,POC1A,KPNA5,CEP112,ZBTB16,USH2A,FGFR1OP,MYRFL,INTU,WDR31,ZNF233,NPIPA5,ABCD2,ECM2,RBM24,CDKL1,BDH1,ANKS1B,TROAP,MYEF2,HIST1H3G,KNCN,C2orf81,FAM149A,TSACC,ADCY2,FABP6,PIP5K1B,NGB,TNFSF13B,TTLL7,C18orf54,LTB4R,STK32C,DMRT2,C12orf76,CENPF,FBXL13,ASCL3,AKAP6,WNT11,MAOB,BBS5,BLM,SVEP1,JPH3,TMEM121,HIST1H2BN,ST8SIA1,HIST1H2AE,CEP126,FAM216A,GIPC2,PHACTR3,CDCA2,PLXNC1,S100A9,MAT1A,FAM227B,LYPD5,NPR3,HMMR,PCYT1B,ARHGAP44,GRM4,METTL12,CES3,ARMCX4,TPPP,TMPRSS7,PLEKHH1,GBP5,ANKRD18B,YEATS2,NECAB1,NR4A2,FANCA,RAET1E,NAF1,ANKRD18A,SH3GL3,AGR3,RAB19,TAGLN3,CILP,ANGPTL5,CDKL3,DOK7,STK31,GIPR,CENPH,PAIP2B,C2orf15,MXD3,IFI44L,WNT8B,FGFBP3,ANKRD45,SLC35F3,PSAPL1,CAPN13,C9orf66,FOXN4,HSF2BP,FGF14,KIAA0101,DMGDH,LMNB1,FAM120C,KIT,C6orf52,XAF1,CNTNAP3,SKA3,CLEC19A,DNM3,SLFN11,HMGB2,STX11,FAM102B,FOXI1,CASC5,MTBP,CEP85,TTK,CAPNS2,SP140,TP53AIP1,RIMS1,DKKL1,ZBTB26,PECAM1,SERPINI2,NCALD,C1orf101,TGM3,RECQL4,CHRNA3,PATL2,GPR156,ZFHX2,HIST2H2BF,BCL11A,PTPRT,KIAA0319,DFNB31,SLC26A8,ZNF19,SYT1,RAD9B,ASCL2,CACNG4,NHS,SERPING1,SEPT5,ZNF497,C6,AGBL3,MTTP,DOCK8,LRRC36,CNTN5,E2F8,SFRP2,CCDC15,MUC5B,RAB6B,HDC,PZP,NMU,GP6,ODF3L1,KIAA0825,C8orf89,SV2C,MT1G,HLA-DQB1,PRRT1,F5,DPEP2,THAP10,ESRRG,B3GNTL1,CDKL4,EML1,CEP135,HSPA2,SCG5,ACSM3,FAM218A,RASSF2,CYP4Z1,PLEKHA4,RHBDL3,PLXND1,FBXW10,HIST1H2AI,CYGB,CXorf57,ATF3,HUNK,HAGHL,CRB1,DZANK1,CSRNP3,CDCA7L,OSBPL6,DLX4,KDR,ESR1,EPM2A,BARX2,CDC14A,CHRNB4,TF,ADGRG3,SEC14L4,SLC7A2,SYNE3,IQGAP3,ZNF711,CXCL10,CCT6B,CLHC1,CXCR2,TRIM36,SAG,LAT2,PRMT8,KLHL32,ATP6V1B1,TPRXL,BSND,APBB1,MAGI2,RPS6KA6,PSD,NOXRED1,ZSCAN5A,PPP1R36,C2orf40,PDE6A,CD226Ngene expressiondifferentially expressedGenes down-regulated by IL-13 stimulation aster infection in allergic asthmainfectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig. 2BTable E1, sheet 2
15
bulk2023-10-20Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 9Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seq
WDR54,TMEM231,CCDC80,CCP110,SAMD15,PROM1,SCG3,LRRC23,DNALI1,C15orf26,CCDC74A,ODC1,SAXO2,C1orf168,CC2D2A,PTGFR,UBXN11,PTH2R,KIAA1211L,C22orf15,CDC20B,TSGA10,C9orf116,SPEF1,C11orf49,CROCC2,WDR38,CCDC33,FAM92B,NPHP1,GAS7,C1orf194,ERICH5,LDLRAD1,CCDC42B,FBXO15,RAB36,HSPBP1,CD38,SAMHD1,CFAP43,LRRC46,TTC26,ZMYND10,SPATA18,RSPH9,TEKT2,LRRC10B,RUVBL1,CYP39A1,CCDC65,C9orf9,WDR63,LRRC48,ARMC4,CCDC113,RUVBL2,STAR,DNAAF1,NEK10,SLC51B,ROPN1L,DNAI1,STK33,C11orf70,TUBB4B,GRAMD2,ODF3B,IQCD,CFAP45,HYDIN,CCDC78,DRC1,WDR49,C2orf50,PSIP1,TCTEX1D4,ENO4,TTC30A,ENKUR,SMIM6,IFT172,P4HTM,VWA3B,TMEM212,ANKRD32,CCDC176,NBEA,SPAG17,C7orf57,TUBA4B,CCDC17,RSPH1,VNN2,MAP3K19,PDK4,DNAH3,EFHC1,RSPH4A,RIBC2,FBXW9,RIBC1,GAS2L2,CCDC170,FAM183A,SPAG8,EFCAB1,DNAH12,TCTN1,TMEM190,PHTF1,CAPS,C11orf16,MDH1B,CFAP221,TTC16,LRRIQ1,GLB1L,CEP41,C10orf107,MNS1,CFAP52,KIF27,C6orf118,CCDC114,SPATA17,C5orf49,AK8,LRRC49,WDR78,TNNC2,AKAP14,CASC1,MORN3,CAPSL,C9orf171,KIF19,ANKMY1,TTC29,APOBEC4,RFX3,IFT57,TNFAIP8L1,IQCG,TNNT3,ARMC3,B9D2,OSCP1,KIF9,EFHC2,B9D1,ADGB,LXN,AGBL2,MORN5,C5AR1,C11orf88,PPIL6,TTLL10,CCDC146,CDHR4,EFHB,FOXJ1,SPEF2,DNAAF3,LRRC71,RPGR,ZMYND12,C20orf85,TTC25,FAM81B,KIAA1407,TCTEX1D1,RPGRIP1L,GPR162,C9orf24,KLHDC9,STOX1,AK7,FAM86B1,C1orf87,M1AP,CATIP,TRIM55,SNTN,CCDC74B,HHLA2,C1orf158,DNAH6,TTLL9,TTC21A,DYNLRB2,ZBBX,C12orf75,CSPP1,AK9,IFT22,DNAH9,HIST3H2BB,PKIG,TTC30B,WDR34,DYRK3,CCDC151,PIH1D3,CERKL,SPAG6,IFT81,C4orf47,GAS8,CLMN,SPATA4,THNSL1,C1orf189,RSPH14,CFAP44,C1orf228,ULK4,LRWD1,C16orf71,TPPP3,DAW1,BSCL2,DYNC2H1,CFAP57,MYB,TSNAXIP1,ACSS3,FAM216B,CLU,CFAP70,CDHR3,CCDC89,NIPSNAP3B,CDK20,TEX9,ZNF688,TMC5,TNFAIP8L3,EFCAB10,KIAA0895,DZIP1L,C21orf58,PHOSPHO2,IQCH,ST8SIA4,DNAL4,FILIP1,KIAA2012,DNAI2,DEGS2,ZCWPW1,PROS1,CFAP36,LRRC6,CLDN3,IFT46,TEKT1,C11orf74,METTL7A,SLC22A4,CFAP58,LCA5L,MAP6,TTC12,DENND6B,GK,TMEM232,KIAA1257,PPP1R32,RABL2A,DNAL1,KATNAL2,STOML3,IL5RA,CFAP20,MORN2,PPP1R42,MARCH10,CFAP61,STMND1,C14orf79,PPOX,MROH9,MAATS1,ANKRD54,CCDC60,LRRC18,CFAP69,C3orf67,SPSB2,LRRC56,SPATA7,CFAP47,WRAP53,ARL6,CCDC13,C10orf67,C9orf72,PIFO,CCDC39,BAALC,ACBD7,NME7,TMEM67,SLC25A14,DTHD1,MLF1,BBS12,KIFAP3,LEKR1,CBY1,C16orf89,CD164L2,IQUB,LRGUK,C14orf142,LMO2,KNDC1,RP1,IFT88,MYCBPAP,CNTF,SRD5A2,PCM1,SPATA6L,MAD2L1,C9orf117,HIST1H2BC,DZIP3,FAM229B,RRAD,CEP95,FAM179A,C2orf73,CCDC108,CFAP53,WDR35,TTC5,DPCD,FAM166B,PIH1D2,NHLRC4,DNAH10,SPA17,PPP1R16A,CDNF,CCDC173,UBXN10,NME9,BEND5,CCDC181,MAK,CCDC121,RASGEF1B,FHAD1,CETN2,DYDC2,KCNH3,CCDC34,LRRC34,EFCAB11,KIF3A,CFAP46,TMCO5A,MOK,TCEAL1,KCNRG,SCLT1,RABL2B,FANK1,AKNA,DYDC1,NF1,SMPD2,OMG,NME5,RIIAD1,CWH43,SCGB2A1,PHF7,FAM92A1,C16orf93,IQCK,LRTOMT,CCDC37,TCTE1,MT1E,LRRC27,CDS1,EFCAB12,NUP62CL,MS4A8,CCDC69,CCDC138,DNAH7,ELK3,ZDHHC1,FAM65B,WDPCP,CEP97,GSTA1,KLHL6,LRMP,CCDC153,TUBA1A,ECT2L,RNF32,IFT52,ODF2L,IFT27,CEP128,HACD4,NAT14,PLCH1,KCNE1,LRP2BP,DRC7,TNFRSF19,PACRG,CLUAP1,WDR90,IFT74,ARHGAP18,CEP83,DCDC1,ZNF474,DNAH5,STPG1,ARMC9,GSTA3,CRISP2,CCDC30,ERICH3,NUDC,DDO,ALDH3B1,COPRS,TMPRSS3,ANKRD42,SLC24A1,LZTFL1,B3GNT5,C11orf65,ZNF214,IL33,C1orf141,ADAM32,CAPS2,DLEC1,CFAP54,NEK11,C1orf110,ZC2HC1C,SMYD2,LRRC74B,TSPAN19,GLIPR2,FBXO36,COL21A1,CFAP74,EFCAB7,LMNTD1,BZRAP1,IFT43,SSBP4,C5orf45,MEIG1,TEKT4,ABCC6,BST1,PLA1A,THRA
Ngene expressionpositively correlated
Genes positively correlated with SARS-CoV-2 viral levels and down-regulated by IL-13 stimulation in allergic asthma
infectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig. 2CTable E2, sheet 1
16
bulk2023-10-20Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 9Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seq
LOXL4,NABP1,RAI14,SLC17A5,SLC26A4,SYNGR2,NEK6,ADAM28,C1QTNF1,CAV1,DHRS7,GNE,PPARG,FCGBP,SSFA2,HPGD,MME,C1orf64,SLC5A5,MGAT1,RUSC1,ID3,SNCA,PARM1,SLC12A2,GALNT7,GCNT3,CST3,TIMP1,DLG1,BCAT1,WSB2,SDC2,VAT1,PTPRQ,TENM2,TRIM16,ADAM9,CST2,UTP20,ME1,PRKCH,FAM46B,TLR4,RNF39,PDZK1IP1,AIM1,MAP1B,BEAN1,PITRM1,CD44,MAPKAPK3,CAMK1D,KCNK6,SH3RF2,PYROXD2,CD320,FAM26E,PLD2,LRRC8A,ARL4C,SNPH,MMP12,PLEKHG6,ADAMTSL3,CDC42EP2,MARVELD3,MMP28,TRIM16L,PPP1R16B,ADA,KCNJ15,CYP27B1,FOXA3
Ngene expressionnegatively correlated
Genes negatively correlated with SARS-CoV-2 viral levels and up-regulated by IL-13 stimulation in allergic asthma
infectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)
occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig 2G, Fig 2H, Fig 2ITable E2, sheet 1
17
sc2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 4Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seqC20orf85,CCDC170,DNAH5,C9orf24,TMEM190,CFAP43,C1orf194,LRRIQ1,FAM216B,SPAG17,CCDC146,MORN2,SAXO2,IGFBP7,C5orf49,CDHR3,WDR78,AGR3,DTHD1,RP1,DNAH7,CAPSL,SNTN,SPA17,CETN2,ARMC3,DYNC2H1,OMG,RSPH4A,AC007906.2,FAM183A,CCDC113,DNAH10,SPEF2,ROPN1L,DNAH3,ODF3B,IFT57,ZMYND10,CASC1,HSPH1,MAP3K19,SPAG6,SPATA18,DYNLRB2,MORN5,EFCAB1,CFAP53,CFAP45,CFAP54,RFX3,CEP126,FOXJ1,ANKUB1,LRRC6,FAM81B,WDR63,IQCG,CFAP44,TSPAN19,C9orf116,ANKRD66,LRRC23,VWA3B,ECT2L,RGS22,EFHC1,LRRC46,PPIL6,ADGB,STK33,CCDC78,DNAH6,CTXN1,DZIP3,TTC29,CCDC173,MAP1A,TEKT1,TMEM232,CFAP57,FAM92B,RSPH9,NEK5,NME5,C11orf88,SSB,CCDC17,C11orf97,CCDC65,WDR49,TMF1,CC2D2A,CFAP52,CFAP70,LDLRAD1,KIF21A,PRKAR1A,IQUB,MLF1,LRRC10B,KIF9,FILIP1,DRC3,DNALI1,TUBA4B,RRAD,AKAP14,C12orf75,HIPK1,FAM229B,PPP4R3B,STOML3,SAMHD1,RIPOR2,NPHP1,TFF3,C20orf85,RSPH1,C9orf24,TUBB4B,CAPS,HSP90AA1,MORN2,C9orf116,PIFO,ROPN1L,FAM183A,TUBA1A,SNTN,C1orf194,TPPP3,CAPSL,C5orf49,CETN2,MORN5,CFAP126,TMEM190,DNALI1,DYNLRB2,C9orf135,OMG,AC007906.2,DYNLT1,TCTEX1D2,NME5,EFCAB1,ZMYND10,CFAP53,IFT57,ODF3B,FAM92B,RSPH9,FAM229B,AKAP14,KIF9,FAM81B,C12orf75,C11orf97,FAM216B,UFC1,ENKUR,C11orf70,MNS1,CCDC74A,CCDC78,AGR3,TCTEX1D4,WDR86-AS1,DYDC2,PSENEN,SRGAP3-AS2,IFT22,MLF1,RRAD,CCDC113,PPIL6,CKB,C22orf15,DPCD,BASP1,CCDC170,WDR38,NUDC,LDLRAD1,CCDC146,TEKT1,WDR54,AC013264.1,RIBC2,CCDC173,LRRC23,EFCAB10,SAXO2,GON7,TUBA4B,IQCG,AC084033.3,LRRIQ1,CFAP73,CARS,IQCD,LRRC46,IK,DTHD1,ARHGAP18,CTXN1,WDR78,SPAG6,SPACA9,ANKRD66,BBOF1,AC004832.1,CCDC39,FANK1,FAM166B,LINC01765,PPP1R42,RIIAD1,PIH1D2,DNAH12,C2orf73,RUVBL1,CCDC153,CABCOCO1,DPY30,SPEF1,TEX26,AK7,CFAP52,PSMA5,TEKT2,CATSPERD,DAW1,PIH1D3,CASC1,IQUB,STOML3,WDR63,TAGLN2,EFCAB2,LRTOMT,MGST3,CCDC65,STMND1,NQO1,NPHP1,LRRC34,LRRC10B,BUD31,SPAG17,ACBD3-AS1,NAA20,C21orf59,SPATA17,C21orf58,ARMC3,FOXJ1,C1orf141,LRRC6,TSPAN19,DYNLRB1,CCDC34,B9D1,CDC20,BRCA2,RNASEH2A,DLGAP5,CENPW,CCNB1,MUC12,HIST1H2BJ,EZH2,PSMC3,RPL39L,CFAP126,ZMYND10,CCDC96,DNALI1,KIF20B,CKS1B,C7orf57,IFT22,RPGR,MOK,B9D2,RUVBL1,PITPNM1,LZTFL1,CFAP36,CCT2,RUVBL2,CCT6A,DPCD,COPRS,HSPH1,NDUFAF3,ANKRD54,AC084033.3,CCP110,HSP90AA1,CAPRIN1,REPIN1,FAM183A,HSPD1,TAF9,SNRPC,EFCAB1,VDAC3,ODF2L,TRAF3IP1,CCT5,SPACA9,PPP1R2,C20orf85,PTMA,CDHR3,DCDC1,DNAH10,ZNF273,AGBL2,GOLGA2P5,CROCC,USP43,ARSEP1,AC234582.1,AC092683.1,DNAI1,SPATA6L,AKNA,SLFN13,SPAG8,WDR19,HMGB1P16,MARCH10,ANKRD36,LINC00893,AC009502.1,MDH1B,CAPS2,ARMC4,VWA3B,CCDC191,ANKRD26,NSUN7,C1orf132,AC013470.2,RRAD,CFAP57,AC004836.1,BCO2,EFCAB1,TSNAXIP1,DZIP3,C5AR1,SPPL2B,SPATA17,KIAA1841,KNDC1,SNTN,ANKMY1,GIPR,SAMD15,CFAP58,ZFHX2,PLCH1,LMLN,TEKT2,PZP,SLC23A1,CCDC57,AC005154.1,IQCD,ZMYND10,FOCAD,LEKR1,BBS9,RAB36,CABIN1
Ngene expressionpositively correlated
Genes positively correlated with SARS-CoV-2 viral levels and down-regulated by IL-13 stimulation in allergic asthma among ciliated cell clusters
infectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig E5, FigE6Table E2, sheet 2

" C4, C8, C13, and C12 had significantly lower expression of ciliated cell–specific marker genes than of C6 ( Fig E5 ) and further that these marker genes were significantly decreased by IL-13"

Ciliated cells (C4, C8, C13); deutersomal cells (C12)
how to curate information for signatures relating to mulitple cells in a cluster? 1 row per cell type of the same DEGs?
18
bulk2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 5Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seqDPP4,POSTN,CST1,SERPINB4,PDCD1LG2,SLC39A8,CEACAM5,ST3GAL4,NTRK1,SLC26A4,CD274,HS3ST1,CFTR,ANO1,FAM26E,SDCBP2,ARNTL2,CDH26,VSIG2,LBH,SLC12A2,GSN,SOCS1,SGK1,RNF39,CASP6,SH2D1B,LRRC8D,CD44,LGALS4,SLC30A4,SSFA2,CDC42EP5,CISH,MAP1B,SERPINB2,MGAT1,ADCY4,ATOH8,B3GNT6,GNE,SPDEF,FCGBP,ME1,DHRS7,MUM1L1,SLC17A5,RAI14,NABP1,CCL26,VAT1,HPGD,FAM177A1,DEAF1,SLC1A5,GCNT4,CMYA5,SECTM1,LOXL4,CLDN5,ARHGAP42,SLC5A8,CD36,CAPN14,TREML2,C8orf4,DSE,FAM46B,LRRC31,SDC2,ETFDH,SLC16A9,ADM2,GCNT3,UAP1,SCIN,SLC7A11,FUT3,ANXA6,RUSC1,GALE,ALPL,SLC6A14,OBFC1,VWF,FZD5,SLC9B2,HOMER2,SYNGR2,CHAC1,CAMK1D,GSTM3,USP54,SLC7A1,CHMP3,CLTB,ST6GAL1,KLF4,AHCYL2,FAM49B,FLT1,ELOVL5,BCL2L15,TRPM4,NFE2,ANKRD9,ANXA3,ALDH1L2,TSPAN3,PCSK6,CYP27B1,HK2,CYTIP,SLC31A1,FETUB,HSBP1L1,PTCHD4,CANT1,PCK2,GALNT5,GPX2,MARVELD3,IDO2,C1QTNF1,HSD17B14,CAP1,KCNK6,TNIP3,DLG1,FAM109B,CTSC,KMO,TMEM30B,CREB3L1,DUOX2,P2RX4,FAM110C,BCAP29,FCHO2,ESAM,SGSH,SERINC1,BLVRB,ATF4,TMSB10,GNPNAT1,NEDD4,PYCR1,LIPH,PDIA5,SLK,SHROOM1,LRRC8A,ABHD17C,SRSF12,SLC39A11,PRKCI,MAOA,EIF4E3,ACER3,PANX2,RTN4R,TRPV6,SPNS2,RNPEPL1,ID3,ORAI1,MAFF,DENND4A,NAPG,STOM,CEACAM21,ANO7,CHRM1,NPDC1,RGS13,FAM26D,CSTA,HPCAL1,ANKRD22,RAB27A,NAMPT,TMEM92,ASPHD2,ADCY7,C12orf49,EDEM3,CA6,GARS,HEXB,CD9,TNFSF10,GFPT1,ASAP3,DUOXA2,PSTPIP1,EPS8L1,MTHFD2,TESK1,SLC9A3,SBDS,SDR16C5,WNT3,PARM1,HPS1,GALNT7,STAC,TIMP1,KRT23,PRB2,TRIM16,YIPF1,INO80D,SUSD2,ORAI3,FOLH1,ZBED2,DNPEP,CHDH,CCBL1,EIF4EBP1,SLC7A4,TSPAN13,LDLRAD3,SLC2A6,BCAT1,OGDHL,MOAP1,RYR2,PSAT1,AK4,EMC3,TRIM7,CYP1B1,IL1A,PRB1,DOK1,FA2H,LOXL3,GRK6,PLS1,NIPAL2,TMC1,STAG1,ADAM9,SERPINB7,CPE,TLR4,RASGRP1,SLC9A4,TRABD2A,CDC42EP2,KLK1,LRRC74A,HES4,KIF1C,TM4SF1,TPD52,CCDC109B,ITSN2,DDX58,GALNT10,TMEM71,HERPUD1,TSEN15,A4GALT,EDNRA,RCN1,CBLC,RAET1L,KRT81,PDLIM4,HYAL1,ITGA10,ERGIC1,CA2,DGKD,OTOGL,ADAM8,LTBR,FNDC4,PFKP,CLCA1,NOS2,MIA3,SLC35G1,PRB4,RNLS,PACSIN3,CD55,NEK6,IL1RL2,NAV1,LONRF1,FZD10,RINL,FAM177B,SLC29A4,TOM1L1,SPRR3,KDELR3,RNF103,PIGR,PQLC2,AIM1,TSPAN8,FAM134B,LATS2,SLCO4A1,C6orf15,ITGB7,TRIM16L,AMOT,RHOC,SLC35D2,VPS37B,CST4,CABLES1,HS3ST2,CH25H,RASL11B,DHX35,MROH6,ALOX15,ATP13A5,RAP1GAP,DDX60,RPP25,KLF8,CST2,KLK7,FER1L6,DOC2B,TCEA3,ERO1L,IL20RB,PTPRO,COG5,S100P,MYO1C,HAS3,IDH1,MLPH,SLC5A3,GXYLT1,MAN2A1,TMPRSS2,DIO2,KRT16,CSRNP1,SLC3A2,HBEGF,FAM173A,ATP12A,GALNT1,ITLN1,MFSD4,HKDC1,C9orf114,MAPKAPK3,ZNF436,GLS,TUBA1C,RAB27B,MGAT3,IDO1,NTRK2,DAB2,ITGB6,SERPINA9,ACPP,RELB,TMPRSS4,CLEC12A,EPHA4,PTS,COMP,TMEM184B,PODXL,HTATIP2,TWF2,RUNX2,SERPINB9,GADD45G,CLLU1OS,HPSE,SERPINB8,UTP20,MET,TRIM62,SHISA4,ARHGAP40,TMEM80,CCDC68,SMOC2,FOXD1,ITGA5,CTSE,CD320,SIDT1,GGH,FCHSD1,SLC35E4,COLGALT2,PON3,VTCN1,SERPINB10,ANKRD28,SOWAHB,DEFB1,S100A16,LDLR,VSIG1,CDK18,FAM83F,STK38L,ZNF467,C1orf64,GOLGA7B,NSMF,LEPR,PEA15,SLC52A2,CREB3L4,TMEM139,AGAP4,CCRL2,LIMK1,SNCA,TARS,AP5B1,OSBPL5,PRDM1,SVIP,TMC6,SLMO2,DNAJB9,TMTC3,LYZ,SREK1IP1,LRP3,HAS2,ATG4D,KCNE3,PLAUR,HS3ST4,BMX,IL37,SLC39A14,TRIB3,F12,ADAMTSL1,PLEKHN1,NIPA1,SLC22A3,SULT1C2,PPAPDC2,PADI3,HPDL,DNAJC10,AZGP1,TNNC1,DISP1,BCL2L14,KAZALD1,P2RY1,ELF4,CCPG1,MMP28,PTHLH,FUT6,GAREML,SLC16A1,ADRA2A,LY6K,PPM1M,GALNT6,CAMTA2,LIFR,SAPCD2,C9orf40,SERPINB13,SEMA3B,TCN1,NRIP3,ESYT3,BACE2,RPTN,MXD1,RBSN,CYP2C18,SLC16A7,CCK,OSGIN1,HMGCS2,SLC30A7,CALU,ARRDC2,RGS20,SRGN,SH3RF2,KRT86,SEC11C,PRSS36,SCEL,FOXA3,DNAJC12,ETV4,CAMSAP3,ZFYVE9,SPHK1,C3orf52,UPK1B,SUCNR1,ANGPTL4,FGF13,BICD1,LHFPL2,KRT40,AFF1,OVGP1,ITPRIPL2,WARS,PDE4C,PRR4,GALNT4,PNPLA7,TUBA4A,ANKRD29,ADAMTSL3,FAM83E,S100A14,ZNF525,RGS2,FAM150A,EVI5L,RRAGD,EPS8L3,GPR153,RAB29,TMBIM1,SLC10A6,TGFBRAP1,CPA4,ADIPOR2,COL13A1,PRSS8,RRAS,GRB10,VCAM1,REG4,ATRNL1,NFKB2Ngene expressiondifferentially expressedGenes up-regulated by IL-13 stimulation after infection in healthy nonsensitized controlsinfectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig 4A, Fig4B
19
bulk2023-10-19Adolescent children with allergic asthma and healthy nonsensitized control (Seattle, Washington)618yearsn = 5Bronchial airway epithelial cells cultured at air-liquid interfaceCL:1001573 (nasopharyngeal epithelial cell)RNA-seqSCGB3A1,GLUL,GRAMD2,CCNO,SCGB1A1,TMEM173,PROM1,POC1A,RERG,CCNA1,ERCC1,SLC13A2,ERICH5,REC8,DYRK3,RUVBL1,IDH2,TDP1,CHL1,CEP78,TTLL5,HES6,TMC5,PFKM,PIM2,SPICE1,CCDC14,KIAA0753,FOCAD,RUVBL2,DNAH5,CEP41,ZNF3,CAPN13,TMEM63C,HSPBP1,NXF3,EXOC3L4,CYP4X1,LRP8,ANKRD54,LPAR3,WDR66,KIFAP3,BPIFA1,PLK4,IQCA1,ISYNA1,HEY1,SCNN1G,POLI,PGBD1,ADGRE5,MYCL,CLMN,STK36,KLHL7,HLA-DOA,TTC30A,CFAP20,KCNH3,FHL1,TP53BP1,CP,SHISA2,RASSF2,ERGIC3,LAG3,SUSD4,ABHD6,SLAIN2,ALMS1,FMO2,IFT122,NEK4,GLA,SLC18B1,HIST1H2BJ,DMXL2,NUDT4,SLC38A4,TRMT12,RPS6KA5,PTH2R,USP10,SAMHD1,E2F7,NECAB1,GPR83,C16orf89,C19orf44,LTF,PLA1A,CAMSAP1,IL33,COPRS,CCDC171,FAM92A1,ACOX2,DNAAF2,RHOBTB1,RAB44,KRT15,TSPAN2,CPOX,EXTL2,B3GNT5,BDH1,NUDC,ZNF300,NLRP1,SLC28A3,EVL,SSRP1,GALM,TST,HIPK1,FLRT3,PNMA1,TCTN1,LRRC61,NOXRED1,FBXO11,KCTD17,TRAF3IP1,AZU1,FOXN4,DMKN,TP53I11,PHTF1,TTC12,CPEB1,ZNF449,HIST1H2BC,CCDC57,TJP3,BBS12,ANKRD42,CACNA1A,CD38,FIBIN,DNALI1,POLN,EID3,ALS2CR11,AKR1C4,CHRM4,PRKAR2B,VAV1,LRRC69,CCDC138,TLL1,IFT46,ANKRD36B,DLX4,ZNF584,INHBB,TMEM45A,AP3M2,RPGRIP1L,ANKMY1,AKR7A2,C2CD2L,TUBB4B,TLR5,CD74,EML6,C11orf63,PCNT,DHX57,HIST1H2AE,CEP95,PNMAL1,C12orf74,PYCRL,FAM19A2,GPR156,KLHDC9,CCDC113,TTC8,AGPAT4,TBC1D31,CYP39A1,YPEL1,LMLN,UNK,EPB41L2,ZNF599,TUBA1A,EBF4,FAM8A1,DNAL4,DALRD3,AKAP3,PHC1,NF1,ZNF550,MYLIP,NPIPB6,CEP89,HCN4,NSUN7,PROS1,TMEM218,OTUD4,IRX6,WRAP53,CC2D2A,ARHGDIB,FAM181B,DOC2A,ZNF440,TUSC3,ANKZF1,FAIM,TTC30B,TRIM66,CKB,IKZF4,TARBP1,KDELC2,SPATA18,PITPNM1,SETD6,ZNF473,SYT5,WDPCP,RSPH10B,TRIM55,THNSL1,WDR77,PRMT8,TNFAIP8L3,HSPH1,TGFBR3,MCAT,KATNAL2,ABCB11,USP13,NFAM1,ODF3B,GP6,RNASEH2A,B9D2,PKIG,GALR2,PLEKHG7,MKS1,CCDC24,GATM,FAM227A,MYLK3,ARNT2,LIN9,PCM1,HRK,LRWD1,IQCD,DNAL1,TSPYL4,BBOX1,GYG2,ASTN2,TNNC2,NAT14,TULP3,KPNA7,SPATS1,C7orf31,CD19,DMD,KIAA1211L,C9orf43,ITIH6,MYL5,C20orf96,ARHGAP30,GDPD2,MTL5,ZFHX2,ABLIM2,OSBPL6,KIF21A,C2orf70,DTNA,CCP110,ODF2,TTC5,PPOX,LXN,FBXW10,KBTBD4,ARMC9,DHX40,ATP8A1,HOGA1,MT3,ZNF491,GPR20,TCEANC2,TMEM231,CCNB1,SMPD2,TBC1D8,DLGAP1,C17orf53,WDR54,PDE7A,EFCAB5,HIST1H2BG,BAG2,PTGER2,PDK4,ZIK1,SHBG,SLC22A17,SMIM10L2A,SLFN13,THRA,IFT52,IFT81,MALL,ZNF607,LGSN,FILIP1,XK,ZNF214,WDR35,ZNF391,CLGN,TMEM17,CERS4,PACRGL,SLC6A16,KIF27,CAPNS2,HELLS,LY6H,GLB1L,FTO,DNAJA4,ORAI2,ULK4,PSIP1,ELK3,GPR135,HIST2H2BF,CES4A,ARHGAP6,C14orf79,ARHGAP24,ECEL1,MAP7D3,INTU,MKL2,FDXR,TTLL6,DDIAS,CHSY3,PRKACB,KIAA1841,EFCAB2,ADGRA1,CNIH2,MDM1,ITGAL,RITA1,KIAA1328,UBXN11,PGBD4,ANAPC4,SAMD15,CXorf58,GP5,FBXO36,LZTFL1,LRRC23,XPNPEP3,CCDC80,DYNC2H1,GLRB,SYTL3,NPM2,ZNF660,PPP1R16A,CNTD2,UBE2U,CRIP1,IFT140,HIST1H2BN,C11orf49,IL16,PSENEN,LMO2,STIL,TRAIP,ARX,TCTN2,HNF4A,SPIN4,NRF1,GJB7,SLC22A4,LRRC37B,PECAM1,FER1L5,MUC16,BARX2,IPO11,WFDC6,BPI,NME7,WDR31,ERICH6,RHPN1,RIN3,TIGD7,ZNF529,EML1,ACSL5,ODF2L,HUNK,UMODL1,KIF6,CAP2,BMPR1B,BTBD3,NCBP2L,CCDC121,SLC6A15,ERCC6L,ABCC2,DTX3,SLC4A8,TP53AIP1,ZNF579,LCA5L,RSPH9,ZNF852,NEMP1,CNTRL,HDC,MAPK8IP1,HAGHL,ABCC4,TMPRSS3,RFX2,DLEU1,CYP2F1,EPPIN,SCG3,C12orf56,SDK1,DERL3,STX2,UBE3D,HEATR5A,HABP2,SLC16A5,GALNS,C9orf72,CEP83,ACAT1,TMEM150C,P4HTM,CFAP36,AKNA,FGFR1OP,IFT172,IRX3,CNTNAP3,DPH7,TMEM200C,PTN,BLMH,HIST1H4D,SCNN1B,RFX3,LY6G5C,NXPE3,SLC43A2,MCIDAS,ARL13B,MOK,RASGEF1B,GRIK2,TEX30,FAM227B,CHP2,ZNF788,ABCD2,MAD2L1,TTC21B,IQCB1,PAQR4,GPM6B,TCTE3,B9D1,UBAC1,SH3TC2,LMCD1,MZF1,FUZ,RTTN,C5AR1,CATSPERG,STK11IP,FAM71E1,PTCD1,TNFRSF11B,TCF7,GSTA1,SNAPC1,SPATA7,WBSCR28,ZNF157,ZC3HAV1L,CCDC67,KLRG2,ACACB,KIF3A,COX6B2,PHF7,CERKL,RMI1,ZC2HC1C,SYNE1,CCDC69,CD34,MUC12,PPP3CB,S100A9,IQCH,C11orf74,NBEA,EFCAB11,BBS5,FAM179B,APH1B,CBY1,VNN2,ACSS1,FAM50B,C5,LRMP,OR13A1,STXBP4,CDS1,LYRM7,C6orf165,NUDT1,FBXW9,RRAD,PPP4R4,CCDC158,C22orf23,GPC3,NAALADL2,ZFP3,PBX1,SMYD2,IFT57,LRRC49,UPK2,CHST9,RARRES1,SKP2,FBF1,DYX1C1,FGGY,ARHGEF4,MT1G,E2F5,IFT27,LRRC26,TBCEL,SKA3,CDC20B,TMEM67,PLAT,FAM47E,C22orf42,CDK20,C12orf60,CSAD,ADPRHL1,ACKR3,TMEM107,TTC26,PAK3,LBHD1,PSD,CDADC1,TAF1B,SPATA6L,FSIP1,PCDHB5,CCDC74A,ATG9B,C16orf93,RGS17,CD96,STK32A,MEX3A,SNCAIP,TLE4,PPP1R32,CYP4Z1,CCDC65,RFC3,CASC10,MCTP1,RBKS,MOBP,CDKL1,MAP6,BBS9,EFCAB7,CD6,BAALC,TTC9B,PAN2,ACBD7,SGOL2,NPHP1,TSGA10Ngene expressiondifferentially expressedGenes down-regulated by IL-13 stimulation after infection in healthy nonsensitized controlsinfectionSevere acute respiratory syndrome coronavirus 2
ncbi_taxid:2697049 (Severe acute respiratory syndrome coronavirus 2)occurrence of infectious diseaseCOVID-19PMID: 370016492023-03-29https://pubmed.ncbi.nlm.nih.gov/37001649/Fig4B
20