MCR Labs - Cannabinoids
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CANNABINOIDSEFFECTS / TREATMENTS OFSOURCE (Study)QUOTE FROM STUDYWeight used in studyRATING
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CannabichromeneCBCAnti-Inflammatory
http://www.sciencedirect.com/science/article/pii/0024320580906311
It was not known if Cannabichromene (CBC), which is a major constituent of drug types of Cannabis, has anti-inflammatory properties as do other cannabinoids.NA5 STARS
3
Antifungal + antibacterial = antimicrobial
http://onlinelibrary.wiley.com/doi/10.1002/j.1552-4604.1981.tb02606.x/full
In both tests, CBC was superior to phenylbutazone. Antibacterial activity of CBC and its isomers and homologs was evaluated using gram-positive, gram-negative, and acid-fast bacteria. Antifungal activity was evaluated using yeastlike and filamentous fungi and a dermatophyte. Antibacterial activity was strong, and the antifungal activity was mild to moderate.NA
4
antiInflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417459/
CBC selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA110 mg·kg−
5
Antimicrobial
http://onlinelibrary.wiley.com/doi/10.1002/j.1552-4604.1981.tb02606.x/full
Antibacterial activity of CBC and its isomers and homologs was evaluated using gram-positive, gram-negative, and acid-fast bacteria. Antifungal activity was evaluated using yeastlike and filamentous fungi and a dermatophyte. Antibacterial activity was strong, and the antifungal activity was mild to moderate.NA
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Analgesic, antiinflammatory
http://onlinelibrary.wiley.com/doi/10.1111/bph.12120/full
Cannabichromene exerts anti-inflammatory actions in activated macrophages – with tonic CB1 cannabinoid signalling being negatively coupled to this effect – and ameliorates experimental murine colitis.NA
7
MRSA
http://pubs.acs.org/doi/pdf/10.1021/np8002673
All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ9-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.NA4 STARS
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CannabidiolCBD
anxiolytic
https://www.ncbi.nlm.nih.gov/pubmed/28553229
The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjects300 mg10 STARS
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Anxiety
https://www.nature.com/npp/journal/v36/n6/full/npp20116a.html
The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC.NA
10
Chronic Pain
http://www.sciencedirect.com/science/article/pii/S0149291807002949
THC/CBD was effective, with no evidence of tolerance, in these select patients with CNP and MS who completed ∼2 years of treatment (n = 28).NA
11
Multiple Sclerosis
http://www.sciencedirect.com/science/article/pii/S0149291807002949
THC/CBD was effective, with no evidence of tolerance, in these select patients with CNP and MS who completed ∼2 years of treatment (n = 28). NA
12
stress
https://www.nature.com/npp/journal/v36/n6/full/npp20116a.html
The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC.NA
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spasticity
http://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2006.01639.x/full
We conclude that this CBM may represent a useful new agent for treatment of the symptomatic relief of spasticity in MS.NA
14

Parkinson’s disease
http://journals.sagepub.com/doi/abs/10.1177/0269881114550355
Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities; however, studies with larger samples and specific objectives are required before definitive conclusions can be drawn.NA
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Epilepsy
https://www.ncbi.nlm.nih.gov/pubmed/25282526
Further data from well-designed studies are needed regarding short- and long-term efficacy and side effects of CBD or high-CBD/low-THC products for the treatment of seizures and epilepsy in children and adults.NA8 STARS
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antipsychotic potential
http://www.sciencedirect.com/science/article/pii/S0920996411002246
Although the observed effects are subtle, using high cannabidiol content cannabis was associated with significantly lower degrees of psychotic symptoms providing further support for the antipsychotic potential of cannabidioNA
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Insomnia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/
This case study offers evidence that CBD is effective as a safe alternative treatment to traditional psychiatric medications for reducing anxiety and insomnia.17NA
18
Anorexia
http://www.neurology.org/content/84/14_Supplement/P6.039.short
These patients illustrate the potential therapeutic use of cannabis in seizure disorders or anorexia. The route of administration (inhaled or buccal) avoids the first-pass effect associated with pill formulations and presents higher levels of cannabinoids such as cannabidiol (CBD) to the endocannabinoid system in the frontal and insular cortex. NA7 STARS
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anti-inflammatory
http://www.sciencedirect.com/science/article/pii/S0168365903004152
In conclusion, ethosomes enable CBD's skin permeation and its accumulation in a depot at levels that demonstrate the potential of transdermal CBD to be used as an anti-inflammatory treatment.NA5 STARS
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antioxidant
http://jpet.aspetjournals.org/content/314/2/780.short
This study provides the first demonstration of CBD as an in vivo neuroprotectant and shows the efficacy of lipophilic antioxidants in preventing binge ethanol-induced brain injury.300 mg
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neuroprotectant
https://www.researchgate.net/profile/Jose_Martinez-Orgado/publication/23148432_Neuroprotective_Effects_of_the_Nonpsychoactive_Cannabinoid_Cannabidiol_in_Hypoxic-Ischemic_Newborn_Piglets/links/00b7d538c6d0f32527000000.pdf
In conclusion, administration of CBD after a HI insult in newborn piglets reduced short-term brain damage, in a manner that can be attributed to a CBD-induced reduction of cerebral hemodynamic impairment, improvement of brain metabolic activity postinsult, reduction of brain edema, and reduction of seizures. These neuroprotective effects were not only free from side effects but also associated with some cardiac, hemodynamic, and ventilatory benefits.
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antidepressant
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00521.x/full
BD (30 mg·kg−1) treatment reduced immobility time in the forced swimming test, as did the prototype antidepressant imipramine, without changing exploratory behaviour in the open field arena.30 mg·kg−1
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analgesic
http://www.sciencedirect.com/science/article/pii/S0014299904012348
We conclude that centrally inactive (+)-cannabidiol analogues should be further developed as antidiarrheal, antiinflammatory and analgesic drugs for gastrointestinal and other peripheral conditions.NA
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anti-tumoral agent
http://jpet.aspetjournals.org/content/308/3/838.short
In conclusion, the nonpsychoactive CBD was able to produce a significant antitumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent.NA
25
Anti-emetic
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01621.x/full
These results suggest that CBD produced its anti-emetic/anti-nausea effects by indirect activation of the somatodendritic 5-HT1A autoreceptors in the DRN.NA
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Anti-bacterial
https://link.springer.com/article/10.1007%2FBF00399444?LI=true
The minimum inhibiting concentrations (MIC) of Ag-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1-5 pg/ml. In the same range, both compounds are also bactericidal. 50μg/ml).
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Anti-proliferative
https://link.springer.com/article/10.1007/s11626-013-9719-9
In addition, these cells were more sensitive to cannabidiol-induced antiproliferative actions through changes in cellular energetics: from a drop of oxygen consumption rate and loss of mitochondrial membrane integrity in cells treated under atmospheric conditions to an increase in reactive oxygen species in intact mitochondria in cells treated under low-oxygen conditions.NA
28
Immunosuppressive
http://www.sciencedirect.com/science/article/pii/S0014299912000052
cannabidiol has anti-inflammatory effects in a murine model of acute lung injury and that this effect is most likely associated with an increase in the extracellular adenosine offer and signaling through adenosine A2A receptor.20 mg/kg
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Depression
https://www.ncbi.nlm.nih.gov/pubmed/27010632
These results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.
15, 30 and 45 mg/kg
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antiiflammatory
http://iovs.arvojournals.org/article.aspx?articleid=2164704
These results suggest that the activated A2AAR in the retinal microglial cells plays a major anti-inflammatory role in the retina and that CBD’s anti-inflammatory effects are linked to the inhibition of adenosine uptake.NA
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gastrointestinal disorder
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2008.01114.x/full
Cannabidiol further reduced gastrointestinal motility in septic mice but did not affect gastrointestinal motility in control mice. NA
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anti-emetic/anti-nausea effects
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01621.x/full
These results suggest that CBD produced its anti-emetic/anti-nausea effects by indirect activation of the somatodendritic 5-HT1A autoreceptors in the DRN.NA
33
anti-convulsant
http://www.sciencedirect.com/science/article/pii/S105913111200057X
In the penicillin model, CBD (≥10 mg/kg) significantly decreased the percentage mortality as a result of seizures; CBD (all doses) also decreased the percentage of animals experiencing the most severe tonic–clonic seizures. ≥10 mg/kg
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Alzheimer's Disease
https://link.springer.com/article/10.1007/s00109-005-0025-1
These results provide new molecular insight regarding the neuroprotective effect of cannabidiol and suggest its possible role in the pharmacological management of AD, especially in view of its low toxicity in humans.NA
35
Osteoporosis
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589495
These results suggest that blocking GPR55 with small molecules such as CBD may be beneficial in bone diseases such as osteoporosis but not osteoarthritis.NA
36
spinal injury
https://link.springer.com/article/10.1007/s12640-011-9273-8
Cannabidiol improved locomotor functional recovery and reduced injury extent, suggesting that it could be useful in the treatment of spinal cord lesions.NA
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Arthritis
http://www.pnas.org/content/97/17/9561.short
Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.NA
38
Anti-psychotic
http://www.sciencedirect.com/science/article/pii/S0014299905002359
In conclusion, cannabidiol exhibits an antipsychotic-like profile without inducing extrapyramidal-like effects.NA
39
Cancer
http://onlinelibrary.wiley.com/doi/10.1016/j.molonc.2014.12.010/full
These results also indicate that CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC, which currently have limited therapeutic options and are associated with poor prognosis and low survival rates.NA
40
Inflammation
http://www.onlinejacc.org/content/56/25/2115
Collectively, these results coupled with the excellent safety and tolerability profile of CBD in humans, strongly suggest that it may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovascular disorders, by attenuating oxidative/nitrative stress, inflammation, cell death and fibrosis.NA
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MRSA
http://pubs.acs.org/doi/abs/10.1021/np8002673
All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ9-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.NA4 STARS
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CannabigerolCBGAnti-Tumor
https://link.springer.com/article/10.1007%2FBF02976895?LI=true
Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration (IC50)=31.3l μ/mL]in vitro assay.31.3l μ/mL5 STARS
43
Anti-Oxidant
https://www.ncbi.nlm.nih.gov/pubmed/28348416
Based on its antioxidant activities, CBG may hold great promise as an anti-oxidant agent and therefore used in clinical practice as a new approach in oxidative-stress related disorders.
NA
44
Anti-inflammatory
https://link.springer.com/article/10.1007/s11481-012-9399-3
As part of a study on the SAR of phytocannabinoids, we have investigated the effect of the oxidation modification in the resorcinol moiety of cannabigerol (CBG) on CB1, CB2 and PPARγ binding affinities, identifying cannabigerol quinone (VCE-003) as a potent anti-inflammatory agentNA
45
Huntington’s Disease
https://www.nature.com/articles/srep29789?WT.feed_name=subjects_neuroscience
a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease.NA
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glaucoma
http://online.liebertpub.com/doi/abs/10.1089/jop.1990.6.259
These results suggest that cannabigerol and related cannabinoids may have therapeutic potential for the treatment of glaucoma.NA
47
Cancer
https://link.springer.com/article/10.1007/BF02975301
Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.NA
48
Irritable bowel syndrome
http://www.sciencedirect.com/science/article/pii/S0006295213000543
In conclusion, CBG attenuated murine colitis, reduced nitric oxide production in macrophages (effect being modulated by the CB2 receptor) and reduced ROS formation in intestinal epithelial cells. CBG could be considered for clinical experimentation in IBD patients.NA
49
Inflammation
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094733
Phytocannabinoids (pCBs) that do not produce psychotropic effects, such as cannabidiol (CBD), cannabigerol (CBG), Δ9 tetrahydrocannabivarin (Δ9THCV) and cannabidivarin (CBDV) [7], are considered of special interest as novel therapeutic agents in CNS diseases. In the CNS, there is evidence that CB1 receptors play a fundamental role in neuroprotection [8], while CB2 receptors expressed primarily in microglia regulate microglial neurotoxicity [9]. Besides the classical membrane CB receptors, nuclear PPARγ receptors have also been shown to be activated by pCBs, and since they attenuate neuroinflammation, pCBs may be of therapeutic interest for the treatment of inflammatory diseases [10].NA
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Antibiotic
http://pubs.acs.org/doi/full/10.1021/np8002673?src=recsys
Evidence that pre-cannabidiol (1a) is a powerful plant antibiotic was, nevertheless, obtained,(4) and more recent investigations have demonstrated, to various degrees, antibacterial activity for the nonpsychotropic cannabinoids cannabichromene (CBC, 2),(5) cannabigerol (CBG, 3b),(6) and cannabidiol (1b),(7) as well as for the psychotropic agent Δ9-tetrahydrocannabinol (THC, 4b).NA4 STARS
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MRSA
http://pubs.acs.org/doi/abs/10.1021/np8002673
All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ9-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.NA
52
CannabinolCBNAppetite Stimulant
https://www.ncbi.nlm.nih.gov/pubmed/22543671
Cannabinol induced a CB(1)R-mediated increase in appetitive behaviors via significant reductions in the latency to feed and increases in consummatory behaviors via increases in meal 1 size and duration.NA5 STARS
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Antibiotic
https://www.ncbi.nlm.nih.gov/pubmed/18681481
Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.NA
54
Potential Medication for ALS
http://www.tandfonline.com/doi/full/10.1080/14660820510030149?scroll=top&needAccess=true
CBN was delivered via subcutaneously implanted osmotic mini‐pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non‐psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.NA
55
Analgesic
https://link.springer.com/article/10.1007/BF00421466
The results of this investigation seem to suggest that both THC and CME possess narcotic-like analgesic activity similar to morphine, while CBN appears to be a non-narcotic type analgesic like aspirin.NA
56
Anticonvulsant
http://www.sciencedirect.com/science/article/pii/0024320574900095
The four principal naturally occurring cannabinoids, Δ9-THC, Δ8-THC, cannabinol and cannabidiol, display anticonvulsant activity, as does the major, primary metabolite of Δ9-THC, 11-hydroxy-Δ9-THC. NA
57
ALS
http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.04346.x/full
Administration of the non-selective partial cannabinoid agonists Δ9-THC (Raman et al. 2004) or cannabinol (Weydt et al. 2005) are minimally successful in delaying motor impairment and prolonging survival in G93A mice after the onset of symptoms. Lastly, a recent study reported elevated levels of CB2 receptors in microglia isolated from post-mortem human spinal cords of ALS patients (Yiangou et al. 2006). Collectively, these studies suggest that cannabinoid receptors might serve as novel therapeutic targets for ALS drug development.NA
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MRSA
http://pubs.acs.org/doi/abs/10.1021/np8002673
All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Δ9-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.NA4 STARS
59
Tetrahydrocannabinol
THC
gastrointestinal disorder
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2036.1999.00441.x/full
It has been reported that THC inhibits gastrointestinal motility in mice.11, 12 Our present findings in humans would also suggest this and support the concept that one of THC’s peripheral effects is to inhibit gastrointestinal smooth muscle actioNA10 STARS
60
stress-relieving
http://www.sciencedirect.com/science/article/pii/S037687161730220X
Our findings suggest that a low dose of THC produces subjective stress-relieving effects in line with those commonly reported among cannabis users, but that higher doses may non-specifically increase negative mood.NA
61
Neuropathic Pain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/
A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep and was well tolerated.NA9 STARS
62
Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394820/
In a trial of a sublingual spray containing delta-9-THC alone or combined with cannabinol, Rog and colleagues reported a 41% reduction in pain, compared with a 22% reduction with placebo.18 Literature on cannabinoids for pain conditions other than multiple sclerosis is limited, although three recent randomized placebo-controlled trials of smoked cannabis found significant reductions in neuropathic pain.NA
63
Crohn's Disease
https://www.ncbi.nlm.nih.gov/pubmed/23648372
Although the primary end point of the study (induction of remission) was not achieved, a short course (8 weeks) of THC-rich cannabis produced significant clinical, steroid-free benefits to 10 of 11 patients with active Crohn's disease, compared with placebo, without side effectsNA
64
Cancer
https://www.ncbi.nlm.nih.gov/pubmed/6985702?dopt=Abstract
We conclude that THC is an effective antiemetic in many patients who receive chemotherapy for cancer and for whom other antiemetics are ineffective.NA8 STARS
65
increase appetite
http://psycnet.apa.org/record/1994-46417-001
Evaluated appetite-stimulating properties of delta-9-tetrahydrocannabinol (THC) in 18 patients (aged 52–81 yrs) with anorexia due to advanced cancer and who had a life expectancy greater than 4 wks. Ss were started on THC 2.5 mg orally 1 hr after meals for 4 wks. Evaluations for side effects, efficacy, acceptability, and satisfaction were conducted at 2 and 4 wks. 10 Ss completed the entire 28-day study; 4 experienced grade 1 toxicity and 3 withdrew at their request. 13 Ss reported an improved appetite. THC is an effective appetite stimulant in patients with advanced cancer. It is well tolerated at low doses. NA
66
Anorexia
http://psycnet.apa.org/record/1994-46417-001
THC is an effective appetite stimulant in patients with advanced cancerNA
67
ADHD
http://mcforadhd.free.fr/ARTICLE%20ADHD%20DRIVING%20GERMANY.pdf
Thus, it has to be considered, that in the case of ADHD, THC can have a typical effects and can even lead to an enhanced driving related performance.71 ng/mL7 STARS
68
anti-inflammatory
http://www.sciencedirect.com/science/article/pii/0014299973901076
The oral anti-inflammatory efficacy of Δ9-THC was compared to phenylbutazone and acetylsalicylic acid.NA5 STARS
69
increase appetite
http://psycnet.apa.org/record/1994-46417-001
Evaluated appetite-stimulating properties of delta-9-tetrahydrocannabinol (THC) in 18 patients (aged 52–81 yrs) with anorexia due to advanced cancer and who had a life expectancy greater than 4 wks. Ss were started on THC 2.5 mg orally 1 hr after meals for 4 wks. Evaluations for side effects, efficacy, acceptability, and satisfaction were conducted at 2 and 4 wks. 10 Ss completed the entire 28-day study; 4 experienced grade 1 toxicity and 3 withdrew at their request. 13 Ss reported an improved appetite. THC is an effective appetite stimulant in patients with advanced cancer. It is well tolerated at low doses. NA
70
reduce nausea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165951/
Cannabinoid agonists (Δ9-THC, HU-210) and the fatty acid amide hydrolase (FAAH) inhibitor, URB-597, suppress conditioned gaping reactions (nausea) in rats as they suppress vomiting in emetic species.NA
71
memory impairment
https://link.springer.com/article/10.1007/BF02246347
Moreover, these results suggest that scopolamine and Δ9-THC do not impair spatial memory in a common serial pathway, though they may converge on a third neurochemical system.2.4 mg/kg
72
antioxidant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20965/
Cannabidiol and THC also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system and neuronal cultures.NA
73
Analgesic
http://www.pnas.org/content/96/10/5780.short
In contrast, we still found Δ9-THC-induced analgesia in the tail-flick test and other behavioral (licking of the abdomen) and physiological (diarrhea) responses after Δ9-THC administration.NA
74
Antidepressant
http://www.sciencedirect.com/science/article/pii/S0091305710000730
Results of this study show that ∆9-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis. 2.5 mg/kg
75
antinociceptive
http://www.sciencedirect.com/science/article/pii/S0014299999006962
Our results indicate that the antinociceptive effects of Δ9-tetrahydrocannabinol are mediated by the concomitant activation of cannabinoid CB1 and dopamine D2 receptors and that dopamine D2 receptor agonists may be useful in improving the analgesic effects of cannabinoids.1 and 5 mg/kg
76
cachexia
http://europepmc.org/abstract/med/9208884
Use of progestogens (megesterol acetate, medroxyprogesterone), corticosteroids (decadron, prednisone), metoclopramide, tetrahydrocannabinol (dronabinol), and possibly anabolic steroids (nandrolone decanoate, oxandrolone), melatonin, and eicosapentaenoic acid, may yield therapeutic benefit.NA
77
Alzheimer's Disease
https://www.ncbi.nlm.nih.gov/pubmed/25024327
These sets of data strongly suggest that THC could be a potential therapeutic treatment option for Alzheimer's disease through multiple functions and pathwaysNA
78
TetrahydrocannabivarinTHCvantiepileptiform and anticonvulsant properties
http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2010.02523.x/full
These data demonstrate that Δ9-THCV exerts antiepileptiform and anticonvulsant properties, actions that are consistent with a CB1 receptor–mediated mechanism and suggest possible therapeutic application in the treatment of pathophysiologic hyperexcitability states.0.25 mg/kg 5 STARS
79
Promotes weightloss
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
THCV is a new potential treatment against obesity-associated glucose intolerance with pharmacology different from that of CB1 inverse agonists/antagonists.NA
80
Anti-Nausea
http://onlinelibrary.wiley.com/doi/10.1111/bph.12322/full
The pattern of findings indicates that neither THCV nor CBDV produced a behavioural profile characteristic of CB1 receptor inverse agonists. As well, these compounds may have therapeutic potential in reducing nausea.10 mg·kg−1
81
anti-acne agents
http://onlinelibrary.wiley.com/doi/10.1111/exd.13042/full
Our data suggest that CBG and CBGV may have potential in the treatment of dry-skin syndrome, whereas CBC, CBDV and especially THCV show promise to become highly efficient, novel anti-acne agentsNA
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SUPPLEMENTARY STUDIES
87
Arachidonoylethanolamine
Anandamide or AEAbiomarker of infertility
https://academic.oup.com/humupd/article/20/4/501/832531/Endocannabinoids-as-biomarkers-of-human
Among the various candidates, endocannabinoids (eCBs), and in particular anandamide (AEA), represent potential biomarkers of human fertility disturbances.
88
CannabichromeneCBCAnti-epileptic
https://www.researchgate.net/profile/Mariana_Babayeva2/publication/271443312_Marijuana_Compounds_A_Non-Conventional_Therapeutic_Approach_to_Epilepsy_in_Children/links/551c13e80cf2909047b9c14d/Marijuana-Compounds-A-Non-Conventional-Therapeutic-Approach-to-Epilepsy-in-Children.pdf
CBD has proven beneficial in experimental models of several neurologic disorders, including those of seizure and epilepsy [97], as have other cannabinoids such as Cannabichromene (CBC) and the propyl homologs of THC and CBD
89
Anti-proliferative
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full
Cannabigerol, cannabichromene, cannabidiol acid and THC acid (Ligresti et al., 2006) as well as desacetyllevonantradol (Ruh et al., 1997) also inhibit cell proliferation in different breast cancer cell lines
90
Anti-depressant
https://pdfs.semanticscholar.org/1304/e5288af80c99e2cae8e223c1536fb49165ef.pdf
Animal depression studies point to doses of THC 2.5 mg/kg, CBD 200 mg/kg, and cannabichromene (CBC) 20 mg/kg acting as an antidepressant in some animal models.
91
Depresion
https://pdfs.semanticscholar.org/1304/e5288af80c99e2cae8e223c1536fb49165ef.pdf
Animal depression studies point to doses of THC 2.5 mg/kg, CBD 200 mg/kg, and cannabichromene (CBC) 20 mg/kg acting as an antidepressant in some animal models
92
CannabidiolCBDAnti-spasmodic
http://www.mdpi.com/1424-8247/3/7/2197/htm
Moreover, CBD has anti-spasmodic, anxiolytic, antinausea and anti-rheumatoid arthritis properties [11].
93
Anti-psychotic
https://www.researchgate.net/profile/Francisco_Guimaraes2/publication/227707576_A_Critical_Review_of_the_Antipsychotic_Effects_of_Cannabidiol_30_Years_of_a_Translational_Investigation/links/543d11510cf20af5cfbfa362.pdf
The first evidence that cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, could have antipsychotic properties was published in 1982 [1]
94
Anti-psoriatichttp://scholarsarchive.jwu.edu/student_scholarship/8/CBD, in repeated studies, has been determined to exhibit a profound number of therapeutic effects acting as an antipsychotic, antiepileptic, neuroprotective, vasorelaxant, antispasmodic, anti-ischemic, anti-proliferative, antiemetic, antibacterial, antipsoriatic, intestinal anti-prokinetic, analgesic, bone stimulant, and anti-inflammatory (Bostwick 172).
95
Intestinal Anti-prokinetic
96
Bone stimulant
97
Cancer
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04298.x/full
On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.
98
stress
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04341.x/full
CBD has also been reported to be neuroprotective, to reduce signs of oxidative stress, to modulate cytokine release and to increase calcium release from neuronal and glial intracellular stores (reviewed in [44]), and at 15 µM to induce mRNA expression of several phosphatases in prostate and colon cancer cells
99
Hypertension
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04351.x/full
The potential ability of CBD treatment in humans to reduce the cardiovascular (as well as behavioural) response to stress could have significant effects on the development of atherosclerosis and hypertension, which are known to be accelerated by stress [51, 52].
100
spasticity
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-9-59
We found evidence that combined THC and CBD extracts may provide therapeutic benefit for MS spasticity symptoms.
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