iGEM 2010: Project Ideas Poll
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NameChoice 1 (Copy and paste)Choice 2 (Copy and paste)Choice 3 (Copy and paste)CommentsPlease choose three ideas from rows 2- 8.List of Ideas: Oil DegradationList of Ideas: Vesicle FormationList of Ideas: Pre-Term LaborList of Ideas: Plastic DegradationList of Ideas: Wound Healing
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Drew EndyList of Ideas: Pre-Term LaborList of Ideas: Vesicle Formationpre-term seems to have interesting sensing and control issues at a foundational level; need to understand what is being detected, can it be detected genetically, and is there a real need or competing technology. vesicle formation needs a crisper "why" (i.e., is the some specific need or reason?). would also recommend not just focusing on mammallian/euko. systems. Oil: Heterologous transfection/expression of metabolic genes.Vesicle: Formation of clathrin-dependent eukaryotic vesicles w/ cargo loading (mammalian or yeast cells).Pre-term: Detection of steroidal compounds (hormones) from the vaginal region (readings directly from the vagina or from secretions).Plastic: Create metabolic oxygenases to oxidize plastic monomers.Healing: Engineer bacteria to promote healing.
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Ryan BloomList of Ideas: Pre-Term LaborList of Ideas: Wound HealingList of Ideas: Plastic DegradationOil: Metabolic simplification (remove anything non-oil related).Vesicle: Formation of clathrin-dependent eukaryotic vesicles w/o cargo loading (mammalian or yeast cells).Pre-term: Integration of multiple signal inputs for one output.Plastic: Trash odor control.Healing: Bacterial immune cloaking.
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IsisList of Ideas: Pre-Term LaborList of Ideas: Plastic DegradationI think the plastic degradation and vesicle formation could be sort of combined through the design of a reliable and flexible protein export system in E. coli.Oil: Integration of multiple metabolic pathways into one organism.Vesicle: Modular domain trans-membrane protein design.Pre-term: instantaneous input sensing vs. inputs over time.Plastic: Regulation of bacterial growth (cyclical pattern).Healing: Bacterial healing stage indicator.
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FranciscoList of Ideas: Pre-Term Labor pre-term labor because i think the sub-goals have potential to be very foundational contributions, such as integrating multiple inputs (and being able to weight the inputs differently), integrating input over time, mix-n-matching two component systems. i'm also interested in exploring how we can exploit different strains of bacteria working in conjunction to accomplish these goals, as well if it is possible to differentially affect the division rate of bacteria.Oil: Optimization of metabolic pathways.Vesicle: Heterologous transfection/expression of clathrin and/or AP-2 complex genes (prokaryote or yeast).Pre-term: Ratiometric gene circuit.Plastic: Regulation of multi-species growth (cyclical-heat pattern).Healing: Formation of collagen matrix.
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Christina SmolkeList of Ideas: Pre-Term LaborList of Ideas: Wound Healing / Concrete SealingList of Ideas: Oil / Trash DegradationPre-term labor is the most exciting in terms of interesting foundational challenges of sensing (time integral, ratiometric) and feasible implementation. Need to look at what would sense, need for this technology, etc and also consider if application should be altered or shifted at all. Oil / Trash seems most risky in terms of intermediate accomplishments that can be recognized if enzymes don't work. Oil: Other.Vesicle: Regulation of vesicle formation (i.e. receptor production or inhibition, etc.).Pre-term: Incoherent feed forward gene loop.Plastic: Other.Healing: Concrete mixed with spores and nutrients to repair cracks.
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Greg OwenPre-Term LaborConcreteI think preterm labor (or another story using the same information processing ideas) has the best chance of winning the prize. Not only does it have a compelling story and foundational advances, it can readily be broken into sub-projects. I think the concrete idea is also cool, less because of its winning potential and more because I find it interestingVesicle: Cargo loading into empty vesicles (i.e. mutated melittin peptide tag).Pre-term: Development of sensors for specific inputs in suitable organism (yeast?), and design of durable and controllable chassis (i.e. removal). Can combine with another project.
Healing: Other.
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YingList of Ideas: Pre-Term LaborList of Ideas: Oil/Plastic DegradationHealing: Concrete mixed with spores and nutrients to repair cracks.Pre-term labor provides a basis for great foundational work, and could be broken up to provide modules and milestones. We'd need to look into which signals are present in the vagina, and what information processing is most appropriate for processing those signals. Other applications could also be found for the information processing. Oil/plastic degradation and self-healing concrete are both really exciting ideas. With oil/plastic degradation, the challenge is that a lot of work has been done; we'd need to find a novel approach. With self-healing concrete, the challenge is that little work has been done; we'd have to make sure it's feasible. (Also, there are currently non-biological methods for making self-healing materials. How could synthetic biology provide a better solution?)Vesicle: Other.
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Chris BrunsonPre-term: Ratiometric gene circuit.Oil: Integration of multiple metabolic pathways into one organism.Vesicle: Cargo loading into empty vesicles (i.e. mutated melittin peptide tag).The ratiometric sensor is my main motivation for this; I'll be honest: I'm not comfortable with the whole pre-term labor; the whole principle is alien to me. However, I really do want to innovate a ratiometric sensor, so I'll go along with this. I think oil/plastic degradation has many applications, especially in industry; it would be cheaper, and much more environmentally friendly. Vesicles are another great idea; I think that if we can implement control of vesicles (both time and contents), then it would have immediate application in gene therapy
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Karina PadillaList of Ideas: Pre-Term LaborList of Ideas: Wound HealingDesalinating Bacteria
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Alejandro VirruetaPre-term: Ratiometric gene circuit.Vesicle transportConcrete healing
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