Cell-Based Meat Genes and Proteins
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The following list of gene / proteins and technologies can be used as a reference for what current cell-based meat companies have discussed in patents / patent applications. It should not be used to understand where companies have protectability. For that, consult an IP lawyer.

"Experimentally validated" means that the company describes an experiment involving the gene / protein in question.

Cell Type, How Used, Product Application, and Species are noted if:
1) The technology described in the patent or patent application is targeted at a specific use case,
2) The experiments described specify any of these data
Keep in mind that often the IP attempts to cover use cases much broader than what is described in the experiments.
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This community resource is being kept up to date (last update 09/02/19). For suggestions, additions, or corrections, contact robert.e.yaman@gmail.com
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Gene / Protein Name
Patent / Application
CompanyFunction
Experimentally validated?
Cell Type (if specified)How Used (if specified)
Product Application (if specified)
Species (if specified)Notes
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MyoD1WO2018011805A9Future MeatMyogenesisYES
Spontaneously Immortalized Fibroblast
Dox-inducible. In Google patents, notated as "myoDl". Sequence here: https://patentscope.wipo.int/search/docs2/pct/WO2018011805/file/WgrRpwlpTJzsJvmC38gBRNjiGwEAW4KkwOAUWzxJ38hazEYk4XeiGo5aQPB6YHptlSn6cXE7Ox-bao5QpVoVtZxrdktzAEWPYQKNj-0KnF1KFrinnRA-g4z_puq632maWWgIA28R7UMhJc81pxdg4Q-GfhhLyTPPoNryRPfRf5U?docId=id00000040900805&psAuth=74OixcPs-tXHCdY4kFhTL0wmgIXaa3rgI3librw1Xf8
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MyogeninWO2018011805A9Future MeatMyogenesisYES
Spontaneously Immortalized Fibroblast
Sequence here: https://patentscope.wipo.int/search/docs2/pct/WO2018011805/file/WgrRpwlpTJzsJvmC38gBRNjiGwEAW4KkwOAUWzxJ38hazEYk4XeiGo5aQPB6YHptlSn6cXE7Ox-bao5QpVoVtZxrdktzAEWPYQKNj-0KnF1KFrinnRA-g4z_puq632maWWgIA28R7UMhJc81pxdg4Q-GfhhLyTPPoNryRPfRf5U?docId=id00000040900805&psAuth=74OixcPs-tXHCdY4kFhTL0wmgIXaa3rgI3librw1Xf8
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HPVE6/E7LOWWO2018011805A9Future MeatImmortalizationNO
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TelomeraseWO2018011805A9Future MeatImmortalizationNO
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SV40WO2018011805A9Future MeatImmortalizationNOVirus
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PPARyWO2018011805A9Future MeatAdipogenesisYES
Spontaneously Immortalized Fibroblast
Ectopically expressed then activated via small molecule
Example 8 includes Dox-inducible vector. PPARg is a transcription factor that can influence genes related to adipogenesis (e.g., ADIPOQ, LPL, NR1H3, and UCP1); genes related to fatty Acid Metabolism (e.g., ACADL, AC ADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, GK, and SCD); genes related to lipid transport (e.g., ADIPOQ, ANGPTL4, APOE, DGAT1, LPL, NR1H3, and OLR1); genes related to cell proliferation (e.g., CLU, ELN, HSPD1, and TXNIP); genes related to insulin signaling (e.g., CPT1A, DGAT1, PCK1, and SORBS 1) and other genes such as MMP9 and PCK1.
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MYOD1US20160227830A1Memphis MeatsMyogenesisYESPorcine iPSC (O2K)
Fused with ESR1 ligand binding domain for E2 induction
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MYOGUS20160227830A1Memphis MeatsMyogenesisNO
Not experimentally validated in the patent application
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MYF5US20160227830A1Memphis MeatsMyogenesisNO
Not experimentally validated in the patent application
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MYF6US20160227830A1Memphis MeatsMyogenesisNO
Not experimentally validated in the patent application
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PAX3US20160227830A1Memphis MeatsMyogenesisNO
Not experimentally validated in the patent application
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PAX7US20160227830A1Memphis MeatsMyogenesisNO
Not experimentally validated in the patent application
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GSK3-beta / CTNNB1US20160227830A1Memphis MeatsMyogenesisYESPorcine iPSC (O2K)See Note
CTNNB1 is usually a phosphorylation target of GSK3-beta. When GSK3-beta is inhibited, CTNNB1 remains active. An alternative to inhibiting GSK3-beta is modying CTNNB1 directly to be constitutively active.
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POU5F1US20160227830A1Memphis MeatsPluripotencyYESPorcine iPSC (O2K)
Transfected with construct allowing for Tet-on induction
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KLF4US20160227830A1Memphis MeatsPluripotencyYESPorcine iPSC (O2K)
Transfected with construct allowing for Tet-on induction
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TERTWO2017124100A1Memphis MeatsImmortalizationYESPrimary myoblast
Direct expression with genetic construct
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CDKN2A / p16 (INK4A)WO2017124100A1Memphis MeatsImmortalizationYESPrimary myoblast
CRISPR Indel mutations knock out CGK2NA gene, which normally inhibits p16
Chicken
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CDKN2B / p15 (INK4B)WO2017124100A1Memphis MeatsImmortalizationYESPrimary myoblast
CRISPR Indel mutations knock out CGK2NB gene, which normally inhibits p15
Cow
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CDK4WO2017124100A1Memphis MeatsImmortalizationYESPrimary myoblast
Direct expression with genetic construct
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YAP1WO2018208628A1Memphis MeatsHIPPO inhibitionYES
Fibroblasts (primary or cell lines)
Plasmid transductionChicken or bovine
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TAZWO2018208628A1Memphis MeatsHIPPO inhibitionYES
Fibroblasts (primary or cell lines)
Plasmid transductionChicken or bovine
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MOB1WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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LATS1WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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LATS2WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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WW45WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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MST1WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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MST2WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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WWTR1WO2018208628A1Memphis MeatsHIPPO inhibitionNO
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Glutamine SynthetaseWO2019014652A1Memphis MeatsGlutamine metabolismYES
Primary fibroblasts and myoblasts
Plasmid transductionDuck
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IGF1WO2019014652A1Memphis MeatsProliferationYES
Primary fibroblasts and myoblasts
Plasmid transductionDuck
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IGF2WO2019014652A1Memphis MeatsProliferationNO
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AlbuminWO2019014652A1Memphis MeatsProliferationYES
Primary fibroblasts and myoblasts
Plasmid transductionDuck
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TERTWO2019014652A1Memphis MeatsImmortalizationNO
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CDKN2A / p16 / INK4AWO2019014652A1Memphis Meats
Inhibition for Immortalization
NO
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CDKN2B / p15 / INK4BWO2019014652A1Memphis Meats
Inhibition for Immortalization
NO
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MYOD1WO2019014652A1Memphis MeatsMyogenesisNO
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MYOGWO2019014652A1Memphis MeatsMyogenesisNO
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MYF5WO2019014652A1Memphis MeatsMyogenesisNO
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MYF6WO2019014652A1Memphis MeatsMyogenesisNO
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PAX3WO2019014652A1Memphis MeatsMyogenesisNO
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PAX7WO2019014652A1Memphis MeatsMyogenesisNO
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YAP1WO2019014652A1Memphis MeatsHIPPO inhibitionNO
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TAZWO2019014652A1Memphis MeatsHIPPO inhibitionNO
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Hepatocyte Nuclear Factor 1 Alpha (HNF1 A)
WO2018227016A1Wild TypeHepatogenesisNO
See Table 1 for an organized list of genes and their purpose
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Hepatocyte Nuclear Factor 4 Alpha (HNF4A)
WO2018227016A1Wild TypeHepatogenesisNO
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FINF1AWO2018227016A1Wild TypeHepatogenesisNO
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FINF4AWO2018227016A1Wild TypeHepatogenesisNO
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Forkhead Box A2 (FOXA2)
WO2018227016A1Wild TypeHepatogenesisNO
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Myogenin (MyoG)WO2018227016A1Wild TypeMyogenesisNO
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Myogenic Differentiation 1 (MyoD)
WO2018227016A1Wild TypeMyogenesisNO
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Myogenic Factor 6 (MRF4)
WO2018227016A1Wild TypeMyogenesisNO
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Myogenic Factor 5 (MYF5)
WO2018227016A1Wild TypeMyogenesisNO
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Fatty Acid Binding Protein 4 (FABP4)
WO2018227016A1Wild TypeAdipogenesisNO
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Insulin- Responsive Glucose Transporter Type 4 (GLUT4)
WO2018227016A1Wild TypeAdipogenesisNO
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AdiponectinWO2018227016A1Wild TypeAdipogenesisNO
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C1Q And Collagen Domain Containing (ADIPOQ)
WO2018227016A1Wild TypeAdipogenesisNO
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l-Acylglycerol-3 -Phosphate O-Acyltransferase 2 (AGPAT2)
WO2018227016A1Wild TypeAdipogenesisNO
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Perilipin 1 (PLIN1)WO2018227016A1Wild TypeAdipogenesisNO
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Leptin (LEP)WO2018227016A1Wild TypeAdipogenesisNO
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Lipoprotein Lipase (LPL)
WO2018227016A1Wild TypeAdipogenesisNO
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ATF4WO2018227016A1Wild TypeSteatosisNO
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ZFP423WO2018227016A1Wild TypeSteatosisNO
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LP EST 1WO2018227016A1Wild TypeSteatosisNO
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PPARG/D/AWO2018227016A1Wild TypeSteatosisNO
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APOC3WO2018227016A1Wild TypeSteatosisNO
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APOEWO2018227016A1Wild TypeSteatosisNO
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ORL1WO2018227016A1Wild TypeSteatosisNO
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PEMTWO2018227016A1Wild TypeSteatosisNO
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MTTPWO2018227016A1Wild TypeSteatosisNO
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SREBPF1WO2018227016A1Wild TypeSteatosisNO
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SREBPF2WO2018227016A1Wild TypeSteatosisNO
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STAT3WO2018227016A1Wild TypeSteatosisNO
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KLF6WO2018227016A1Wild TypeSteatosisNO
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LPIN!WO2018227016A1Wild TypeSteatosisNO
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Oct3/4, WO2018227016A1Wild TypeReprogramming / iPSCsNO
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Sox2WO2018227016A1Wild TypeReprogramming / iPSCsNO
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Klf4WO2018227016A1Wild TypeReprogramming / iPSCsNO
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L- MycWO2018227016A1Wild TypeReprogramming / iPSCsNO
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C-MycWO2018227016A1Wild TypeReprogramming / iPSCsNO
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N-MycWO2018227016A1Wild TypeReprogramming / iPSCsNO
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Lin28WO2018227016A1Wild TypeReprogramming / iPSCsNO
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NanogWO2018227016A1Wild TypeReprogramming / iPSCsNO
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GLIS1WO2018227016A1Wild TypeReprogramming / iPSCsNO
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Lin4WO2018227016A1Wild TypeReprogramming / iPSCsNO
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bFGFWO2018227016A1Wild TypeESC IsolationNO
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IGF-1WO2018227016A1Wild TypeESC IsolationNO
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mSCFWO2018227016A1Wild TypeESC IsolationNO
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IL-6WO2018227016A1Wild TypeESC IsolationNO
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OSMWO2018227016A1Wild TypeESC IsolationNO
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LIFWO2018227016A1Wild TypeESC IsolationNO
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IL-6WO2018227016A1Wild TypeESC IsolationNO
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IL-11WO2018227016A1Wild TypeESC IsolationNO
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LIFWO2018227016A1Wild TypePluripotencyNO
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p53WO2018227016A1Wild TypeImmortalizationNO
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SV40 Large T AntigenWO2018227016A1Wild TypeImmortalizationNO
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hTERTWO2018227016A1Wild TypeImmortalizationNO
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UPV E6/E7WO2018227016A1Wild TypeImmortalizationNO
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