https://www.sciencedirect.com/science/article/abs/pii/S0960982200001779

Kodaki T, Woscholski R, Hallberg B,…Parker P

Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase

https://pubmed.ncbi.nlm.nih.gov/7929193/

Woscholski R, Dhand R, Fry MJ, Waterfield MD, Parker PJ

Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene

https://pubmed.ncbi.nlm.nih.gov/7713498/

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

https://pubmed.ncbi.nlm.nih.gov/8090789/

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

https://pubmed.ncbi.nlm.nih.gov/8749393/

Modulation of the substrate specificity of the mammalian phosphatidylinositol 3-kinase by cholesterol sulfate and sulfatide

CHOLESTEROL SULFATE / SULFATIDE

https://pubmed.ncbi.nlm.nih.gov/7547877/

Woscholski R, Kodaki T, Palmer RH, Waterfield MD, Parker PJ

Phosphatidylinositol 3-kinase is involved in TRE-dependent gene expression in response to arginine vasopressin

https://www.sciencedirect.com/science/article/abs/pii/S0006291X85725685

Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase

https://www.sciencedirect.com/science/article/pii/S0960982202707136

Didichenko SA, Tilton B, Hemmings BA, Ballmer-Hofer K, Thelen M

Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase

https://pubmed.ncbi.nlm.nih.gov/9043658/

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231743/

Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily

https://pubmed.ncbi.nlm.nih.gov/9196049/

Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes

https://pubmed.ncbi.nlm.nih.gov/9252478/

Ozanne SE, Nave BT, Wang CL, Shepherd PR, Prins J, Smith GD

Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110 alpha and WRN during fibroblast aging in vitro

https://pubmed.ncbi.nlm.nih.gov/9531977/

The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets

https://ashpublications.org/blood/article/91/3/930/261098/The-p85-and-p110-Subunits-of-Phosphatidylinositol

Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors

https://www.sciencedirect.com/science/article/abs/pii/S0009308499000201

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC306608/

Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor

https://pubmed.ncbi.nlm.nih.gov/10633084/

The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling

https://pubmed.ncbi.nlm.nih.gov/10633072/

Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270090/

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities

https://pubmed.ncbi.nlm.nih.gov/12145276/

Foukas LC, Daniele N, Ktori C, Anderson KE, Jensen J, Shepherd PR

https://pubmed.ncbi.nlm.nih.gov/12704201/

Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor

https://pubmed.ncbi.nlm.nih.gov/12882977/

Kaplan-Albuquerque N, Garat C, Desseva C, Jones PL, Nemenoff RA

Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321424/

Foukas LC, Beeton CA, Jensen J, Phillips WA, Shepherd PR

Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development.

https://pubmed.ncbi.nlm.nih.gov/15020683/

Lu DP, Chandrakanthan V, Cahana A, Ishii S, O'Neill C

Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways

https://pubmed.ncbi.nlm.nih.gov/16565309/

Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.20707

https://pubmed.ncbi.nlm.nih.gov/17561399/

Vogt PK, Kang S, Elsliger MA, Gymnopoulos M

Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins

https://pubmed.ncbi.nlm.nih.gov/17680774/

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

MST1 / RANBP2 / EIF4G BIOMARKERS

https://pubmed.ncbi.nlm.nih.gov/17372272/

Renner O, Fominaya J, Alonso S, Blanco-Aparicio C, Leal JF, Carnero A

Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients

https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.32023

Julie CS, Joyce TT, Jiddeke MvdK, Fleur SvD, Lowry RB, Leslie GB

Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern

https://pubmed.ncbi.nlm.nih.gov/17673550/

Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer

https://pubmed.ncbi.nlm.nih.gov/17377809/

Woenckhaus J, Steger K, Sturm K, Münstedt K, Franke FE, Fenic I

Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport

https://pubmed.ncbi.nlm.nih.gov/18653476/

Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D

https://pubmed.ncbi.nlm.nih.gov/18794883/

Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome: CNS malformations and seizures may be a component of this disorder

https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.32515

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720137/

Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM

https://pubmed.ncbi.nlm.nih.gov/18794885/

Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike

https://www.sciencedirect.com/science/article/pii/S1535610808002316

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

https://pubmed.ncbi.nlm.nih.gov/19029981/

Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose

https://pubmed.ncbi.nlm.nih.gov/18247380/

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations

NEED TO REVIEW

https://pubmed.ncbi.nlm.nih.gov/18829560/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398461/

PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences

https://pubmed.ncbi.nlm.nih.gov/18180098/

The regulation of selective and nonselective Na+ conductances in H441 human airway epithelial cells

https://pubmed.ncbi.nlm.nih.gov/18310228/

Brown SG, Gallacher M, Olver RE, Wilson SM

Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome

https://journals.lww.com/clindysmorphol/Abstract/2009/01000/Characterization_of_a_distinct_syndrome_that.1.aspx

Involvement of the p110 alpha isoform of PI3K in early development of mouse embryos

https://pubmed.ncbi.nlm.nih.gov/18932194/

Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction

CARDIAC / CONTRACTILE DYSFUNCTION

https://pubmed.ncbi.nlm.nih.gov/19597047/

The misnomer "macrocephaly-cutis marmorata telangiectatica congenita syndrome": report of 12 new cases and support for revising the name to macrocephaly-capillary malformations.

https://pubmed.ncbi.nlm.nih.gov/19289759/

Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes

https://pubmed.ncbi.nlm.nih.gov/19065634/

https://pubmed.ncbi.nlm.nih.gov/19380062/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724395/

VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway

https://pubmed.ncbi.nlm.nih.gov/19337377/

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1525-1470.2010.01149.x

CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism

https://europepmc.org/article/med/20537357

Ahmad IA, Burrows PE, Edward YL, Daniel H, John BM, Steven JF

https://pubmed.ncbi.nlm.nih.gov/20888465/

https://pubmed.ncbi.nlm.nih.gov/19931507/

https://pubmed.ncbi.nlm.nih.gov/20542174/

The group of epidermal nevus syndromes Part II. Less well defined phenotypes

https://pubmed.ncbi.nlm.nih.gov/20542175/

Hemihyperplasia-multiple lipomatosis syndrome: an underdiagnosed entity in children with asymmetric overgrowth

https://pubmed.ncbi.nlm.nih.gov/20105568/

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0004.2010.01479.x

Klippel-Trenaunay syndrome and spinal arteriovenous malformations: an erroneous association

https://pubmed.ncbi.nlm.nih.gov/20651014/

https://pubmed.ncbi.nlm.nih.gov/20155260/

Fernandez-Pineda I, Fajardo M, Chaudry G, Alomari AI.

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts

https://www.nature.com/articles/cdd2009150

PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA

https://pubmed.ncbi.nlm.nih.gov/20237330/

Progressive overgrowth of the cerebriform connective tissue nevus in patients with Proteus syndrome

PROTEUS SYNDROME / CEREBRIFORM

https://pubmed.ncbi.nlm.nih.gov/20709429/

Thomas MB, Julie CS, Leslie GB, Thomas D.

Syndromes with focal overgrowth in infancy: diagnostic approach and surgical treatment

https://pubmed.ncbi.nlm.nih.gov/21446802/

Ursula M, Silke A, Olivia L-S, Petra M, Wolfgang S

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292322/

Mohar Chattopadhyay, Elzbieta S. Selinger, Lisa M. Ballou, Richard Z. Lin

https://pubmed.ncbi.nlm.nih.gov/21504461/

Complex spinal-paraspinal fast-flow lesions in CLOVES syndrome: analysis of clinical and imaging findings in 6 patients

http://www.ajnr.org/content/32/10/1812.long

Diagnosis and management of extensive vascular malformations of the lower limb: part I. Clinical diagnosis

https://pubmed.ncbi.nlm.nih.gov/22000870/

Direct effects of rapid-acting insulin analogues on insulin signaling in human pancreatic islets in vitro

https://pubmed.ncbi.nlm.nih.gov/21354844/

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition

https://pubmed.ncbi.nlm.nih.gov/21778304/

Zheng Z, Amran SI, Thompson PE, Jennings IG

A proposal for classification of entities combining vascular malformations and deregulated growth

https://pubmed.ncbi.nlm.nih.gov/21356335/

Charlène EUO, Chantal MAMvdH, Smitt JHS, et al

https://pubmed.ncbi.nlm.nih.gov/22739355/

Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor

https://www.sciencedirect.com/science/article/abs/pii/S0928098712003673

Talekar M, Kendall J, Denny W, Jamieson S, Garg S

Isolated macrodystrophia lipomatosa of the foot in a neonate: a case report

https://pubmed.ncbi.nlm.nih.gov/21959860/

Guzoglu N, Gokmen T, Oguz SS, Fitoz S, Dilmen U

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854320/

Murat CB, Braga PB, Fortes MA, Bronstein MD, Corrêa-Giannella ML, Giorgi RR

The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645353/

https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.35383

Klein S, Stroberg A, Ghahremani S, Martinez-Agosto JA

https://www.cell.com/ajhg/fulltext/S0002-9297(12)00262-5

https://linkinghub.elsevier.com/retrieve/pii/S0363-5023(13)01188-X

Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy.

https://pubmed.ncbi.nlm.nih.gov/23632263/

Lymphatic vessel abnormalities arising from disorders of Ras signal transduction

https://pubmed.ncbi.nlm.nih.gov/24183794/

https://www.sciencedirect.com/science/article/abs/pii/S0733863512001714?via%3Dihub

PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition

https://pubmed.ncbi.nlm.nih.gov/23439433/

https://pubmed.ncbi.nlm.nih.gov/23946963/

Mirzaa G, Conway R, Graham JM, Jr., Dobyns WB

GeneReviews(®). Seattle (WA): University of Washington, Seattle

Reconstructive surgery in the management of a patient with CLOVES syndrome

https://pubmed.ncbi.nlm.nih.gov/23867238/

Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly

https://pubmed.ncbi.nlm.nih.gov/23100325/

Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer

https://pubmed.ncbi.nlm.nih.gov/23172887/

Activating PIK3CA somatic mutation in congenital unilateral isolated muscle overgrowth of the upper extremity

https://pubmed.ncbi.nlm.nih.gov/24975390/

Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum

https://pubmed.ncbi.nlm.nih.gov/24782230/

Keppler-Noreuil KM, Sapp JC, Lindhurst MJ, et al

https://pubmed.ncbi.nlm.nih.gov/25365848/

Puvabanditsin S, Memon N, Chekmareva M, Di Stefano V, Mehta R

CLOVES syndrome: a malformational syndrome closely resembling Proteus syndrome

https://pubmed.ncbi.nlm.nih.gov/25209813/

https://pubmed.ncbi.nlm.nih.gov/25184530/

https://pubmed.ncbi.nlm.nih.gov/25241101/

Megalencephaly syndromes: exome pipeline strategies for detecting low-level mosaic mutations

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908952/

https://www.hindawi.com/journals/cripe/2014/845074/

Sarici D, Akin MA, Kurtoglu S, Tubas F, Sarici SU

The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma

https://www.nature.com/articles/onc2012594

Munugalavadla V, Mariathasan S, Slaga D, et al.

PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2

https://pubmed.ncbi.nlm.nih.gov/24645666/