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FULL TITLETOPICReviewed:KEY WORDSLinkDISORDERType of docPDF?YearAuthorsPublished in
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The activation of phosphatidylinositol 3-kinase by RasPI3KNOBASIC RESEARCH
https://www.sciencedirect.com/science/article/abs/pii/S0960982200001779
NEITHERRESEARCHYES1994
Kodaki T, Woscholski R, Hallberg B,…Parker P
Curr Biol.
3
Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase
PI3KNOBIOCHEMISTRY
https://pubmed.ncbi.nlm.nih.gov/7929193/
NEITHERRESEARCHYES1994
Woscholski R, Dhand R, Fry MJ, Waterfield MD, Parker PJ
J Biol ChemPI3K
4
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene
PI3KNOCLONING / IDENTIFICATION
https://pubmed.ncbi.nlm.nih.gov/7713498/
NEITHERRESEARCHYES1994Volinia S, Hiles I, Ormondroyd E, et alGenomics
5
The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors
PI3KNODNA SYNTHESIS
https://pubmed.ncbi.nlm.nih.gov/8090789/
NEITHERREVIEWYES1994Roche S, Koegl M, Courtneidge SAProc Natl Acad Sci U S A
6
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
PI3KNOBASIC RESEARCH
https://pubmed.ncbi.nlm.nih.gov/8749393/
NEITHERRESEARCHYES1995
MacDougall LK, Domin J, Waterfield MD
Curr Biol.
7
Modulation of the substrate specificity of the mammalian phosphatidylinositol 3-kinase by cholesterol sulfate and sulfatide
PI3KNO
CHOLESTEROL SULFATE / SULFATIDE
https://pubmed.ncbi.nlm.nih.gov/7547877/
NEITHERRESEARCHYES1995
Woscholski R, Kodaki T, Palmer RH, Waterfield MD, Parker PJ
Biochemistry
8
Phosphatidylinositol 3-kinase is involved in TRE-dependent gene expression in response to arginine vasopressin
PI3KNOPI3K
https://www.sciencedirect.com/science/article/abs/pii/S0006291X85725685
NEITHERRESEARCHYES1995Nishioka N, Akimoto K, Moriya S, et alBiochem Biophys Res Commun
9
Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase
PI3KNOBASIC RESEARCH
https://www.sciencedirect.com/science/article/pii/S0960982202707136
NEITHERRESEARCHYES1996
Didichenko SA, Tilton B, Hemmings BA, Ballmer-Hofer K, Thelen M
Curr Biol.
10
Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase
PI3KNOBASIC RESEARCH
https://pubmed.ncbi.nlm.nih.gov/9043658/
NEITHERRESEARCHYES1997
Stirdivant SM, Ahern J, Conroy RR, et al
Bioorg Med Chem
11
Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
PI3KNOADIPOCYTES
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231743/
NEITHERREVIEWYES1997Frevert EU, Kahn BBMol Cell Biol
12
Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily
PI3KNONOVEL PI3K ISOFORMS
https://pubmed.ncbi.nlm.nih.gov/9196049/
NEITHERRESEARCHYES1997
Ho LK, Liu D, Rozycka M, Brown RA, Fry MJ
Biochem Biophys Res Commun
13
Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes
PI3KNOINSULIN
https://pubmed.ncbi.nlm.nih.gov/9252478/
NEITHERRESEARCHYES1997
Ozanne SE, Nave BT, Wang CL, Shepherd PR, Prins J, Smith GD
Am J Physiol
14
Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110 alpha and WRN during fibroblast aging in vitro
PI3KNOSIGNALING
https://pubmed.ncbi.nlm.nih.gov/9531977/
NEITHERRESEARCHYES1998Matuoka K, Takenawa TBiochim Biophys Acta
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The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets
PI3KNOPLATELETS
https://ashpublications.org/blood/article/91/3/930/261098/The-p85-and-p110-Subunits-of-Phosphatidylinositol
NEITHERRESEARCHYES1998Geltz NR, Augustine JABlood
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Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors
PI3KNOGPCR
https://www.sciencedirect.com/science/article/abs/pii/S0009308499000201
NEITHERRESEARCHYES1999Katada T, Kurosu H, Okada T, et alChem Phys Lipids
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Negative regulation of PI 3-kinase by Ruk, a novel adaptor proteinPI3KNORUK PROTEIN
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC306608/
NEITHERRESEARCHYES2000Gout I, Middleton G, Adu J, et alEmbo j
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Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor
PI3KNOVESICLE FORMATION
https://pubmed.ncbi.nlm.nih.gov/10633084/
NEITHERRESEARCHYES2000Murray J, Wilson L, Kellie S J Cell Sci
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The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling
PI3KNOISOFORMS
https://pubmed.ncbi.nlm.nih.gov/10633072/
NEITHERRESEARCHYES2000
Hooshmand-Rad R, Hájková L, Klint P, et al
J Cell Sci
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Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway
PI3KNOBIOCHEMISTRY
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270090/
NEITHERRESEARCHYES2000Fitzgerald EMJ Physiol
21
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities
PI3KNOCAFFEINE / THEOPHYLLINE
https://pubmed.ncbi.nlm.nih.gov/12145276/
NEITHERRESEARCHYES2002
Foukas LC, Daniele N, Ktori C, Anderson KE, Jensen J, Shepherd PR
J Biol Chem
22
Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt
PI3KNOBASIC RESEARCH
https://pubmed.ncbi.nlm.nih.gov/12704201/
NEITHERRESEARCHYES2003
Ballou L, Lin H-Y, Fan G, Jiang Y-P, Lin RZ
J Biol Chem
23
Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor
PI3KNOAKT
https://pubmed.ncbi.nlm.nih.gov/12882977/
NEITHERRESEARCHYES2003
Kaplan-Albuquerque N, Garat C, Desseva C, Jones PL, Nemenoff RA
J Biol Chem
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Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo
PI3KNOREGULATION
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321424/
NEITHERRESEARCHYES2004
Foukas LC, Beeton CA, Jensen J, Phillips WA, Shepherd PR
Mol Cell Biol
25
Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development.
PI3KNODEVELOPMENT
https://pubmed.ncbi.nlm.nih.gov/15020683/
NEITHERRESEARCHYES2004
Lu DP, Chandrakanthan V, Cahana A, Ishii S, O'Neill C
J Cell Sci
26
Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways
PI3KNOHYPERINSULINEMIA
https://pubmed.ncbi.nlm.nih.gov/16565309/
PROSRESEARCHYES2006
Samuelsson AM, Bollano E, Mobini R, et al
Am J Physiol Heart Circ Physiol
27
Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression
PI3KNOANGIOGENESIS
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.20707
NEITHERRESEARCHYES2006Xia C, Meng Q, Cao Z, Shi X, Jiang BHJ Cell Physiol
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Cancer-specific mutations in phosphatidylinositol 3-kinasePI3KNOCANCER
https://pubmed.ncbi.nlm.nih.gov/17561399/
NEITHERREVIEWYES2007
Vogt PK, Kang S, Elsliger MA, Gymnopoulos M
Trends Biochem Sci
29
Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins
PI3KNOREGULATION
https://pubmed.ncbi.nlm.nih.gov/17680774/
NEITHERREVIEWYES2007Wang P, Kumar P, Wang C, Defea KABiochem J
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Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.
PI3KNO
MST1 / RANBP2 / EIF4G BIOMARKERS
https://pubmed.ncbi.nlm.nih.gov/17372272/
NEITHERRESEARCHYES2007
Renner O, Fominaya J, Alonso S, Blanco-Aparicio C, Leal JF, Carnero A
Carcinogenesis
31
Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients
PHENOTYPEYESLIPOMATOSIS
https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.32023
CLOVESCASE REPORTYES2007
Julie CS, Joyce TT, Jiddeke MvdK, Fleur SvD, Lowry RB, Leslie GB
Am J Med Genet A
32
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
PI3KNOEPIDERMAL DEVI
https://pubmed.ncbi.nlm.nih.gov/17673550/
NEITHERRESEARCHYES2007
Hafner C, López-Knowles E, Luis NM, et al
Proc Natl Acad Sci U S A
33
Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer
PI3KNOOVARIAN CANCER
https://pubmed.ncbi.nlm.nih.gov/17377809/
NEITHERRESEARCHYES2007
Woenckhaus J, Steger K, Sturm K, Münstedt K, Franke FE, Fenic I
Virchows Arch
34
Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport
PI3KNOBASIC RESEARCH
https://pubmed.ncbi.nlm.nih.gov/18653476/
NEITHERRESEARCHYES2008
Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D
Am J Physiol Renal Physiol
35
Class I PI3K in oncogenic cellular transformationPI3KNOCANCER
https://pubmed.ncbi.nlm.nih.gov/18794883/
NEITHERRESEARCHYES2008Zhao L, Vogt PKOncogene
36
Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome: CNS malformations and seizures may be a component of this disorder
PHENOTYPEYESSEIZURES
https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.32515
CLOVESCASE REPORTYES2008
Zoran SG, Velibor T, Aleksandra J, et al
Am J Med Genet A
37
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha
PI3KNODRUG RESISTANCE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720137/
NEITHERRESEARCHYES2008
Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM
Cancer Cell
38
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
PI3KNOTREATMENT / CANCER
https://pubmed.ncbi.nlm.nih.gov/18794885/
NEITHERREVIEWYES2008Garcia-Echeverria C, Sellers WROncogene
39
Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike
PI3KNODRUG RESISTANCE
https://www.sciencedirect.com/science/article/pii/S1535610808002316
NEITHERRESEARCHYES2008Vogt PKCancer Cell
40
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
PI3KNO
PIK3CA H1047R / PI3K INHIBITOR
https://pubmed.ncbi.nlm.nih.gov/19029981/
NEITHERRESEARCHYES2008Engelman JA, Chen L, Tan X, et alNat Med
41
Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose
PI3KNO2-DEOXYGLUCOSE
https://pubmed.ncbi.nlm.nih.gov/18247380/
NEITHERRESEARCHYES2008Jiang W, Zhu Z, Thompson HJMol Carcinog
42
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
PI3K
NEED TO REVIEW
NVP-BEZ235 / CANCER
https://pubmed.ncbi.nlm.nih.gov/18829560/
NEITHERRESEARCHYES2008Serra V, Markman B, Scaltriti M, et alCancer Res.
43
PI3K pathway alterations in cancer: variations on a themePI3KNOCANCER
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398461/
NEITHERREVIEWYES2008Yuan TL, Cantley LCOncogene
44
PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences
PI3KNOUTERINE CANCERS
https://pubmed.ncbi.nlm.nih.gov/18180098/
NEITHERCASE REPORTYES2008Miyake T, Yoshino K, Enomoto T, et alCancer Lett
45
The regulation of selective and nonselective Na+ conductances in H441 human airway epithelial cells
PI3KNOBIOCHEMISTRY
https://pubmed.ncbi.nlm.nih.gov/18310228/
NEITHERRESEARCHYES2008
Brown SG, Gallacher M, Olver RE, Wilson SM
Am J Physiol Lung Cell Mol Physiol
46
Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome
PHENOTYPEYESSTUDY OF 18 CLOVES
https://journals.lww.com/clindysmorphol/Abstract/2009/01000/Characterization_of_a_distinct_syndrome_that.1.aspx
CLOVESCASE REPORTYES2009Ahmad IAClin Dysmorphol
47
Involvement of the p110 alpha isoform of PI3K in early development of mouse embryos
PI3KNOMOUSE
https://pubmed.ncbi.nlm.nih.gov/18932194/
NEITHERRESEARCHYES2009Xu XY, Zhang Z, Su WH, et alMol Reprod Dev
48
Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction
PI3KNO
CARDIAC / CONTRACTILE DYSFUNCTION
https://pubmed.ncbi.nlm.nih.gov/19597047/
NEITHERRESEARCHYES2009Lu Z, Jiang YP, Wang W, et alCirculation
49
The misnomer "macrocephaly-cutis marmorata telangiectatica congenita syndrome": report of 12 new cases and support for revising the name to macrocephaly-capillary malformations.
PHENOTYPEYESMACROCEPHALY
https://pubmed.ncbi.nlm.nih.gov/19289759/
PROSCASE REPORTYES2009
Dakara Rucker W, Ilona JF, Seth JO, et al
JAMA Dermatol
50
Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes
PI3KNOCELL SURVIVAL
https://pubmed.ncbi.nlm.nih.gov/19065634/
NEITHERRESEARCHYES2009
Espada J, Galaz S, Sanz-Rodríguez F, et al
J Cell Physiol
51
Overgrowth conditions: a diagnostic and therapeutic conundrumDIAGNOSISYESPERSPECTIVE
https://pubmed.ncbi.nlm.nih.gov/19380062/
PROSREVIEWYES2009Matthew JC, Amir T, Joseph UHand Clinics
52
PIK3CA alterations in Middle Eastern ovarian cancersPI3KNOOVARIAN CANCER
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724395/
NEITHERREVIEWYES2009Abubaker J, Bavi P, Al-Haqawi W, et alMol Cancer.
53
VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway
PI3KNOVEGF / CANCER
https://pubmed.ncbi.nlm.nih.gov/19337377/
NEITHERRESEARCHYES2009Chen CH, Lai JM, Chou TY, et alPLoS One
54
CLOVE syndrome with nevus unis lateris: report of a casePHENOTYPEYESNEVUS UNIS LATERIS
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1525-1470.2010.01149.x
CLOVESCASE REPORTYES2010Deepika H, Anju APediatr Dermatol
55
CLOVES syndrome with thoracic and central phlebectasia: increased risk of pulmonary embolism
PHENOTYPEYESPHLEBECTASIA
https://europepmc.org/article/med/20537357
CLOVESCASE REPORTYES2010
Ahmad IA, Burrows PE, Edward YL, Daniel H, John BM, Steven JF
J Thoracis Cardiovascular Surgery
56
Epidermal neviPHENOTYPEYESEpidermal nevi
https://pubmed.ncbi.nlm.nih.gov/20888465/
PROSREVIEWYES2010Heather AB-B, Kimberly DMPediatr Clinics NA
57
Evidence for a role for the p110-alpha isoform of PI3K in skeletal function
PI3KNOSKELETAL FUNCTION
https://pubmed.ncbi.nlm.nih.gov/19931507/
NEITHERRESEARCHYES2010
Grey A, Chaussade C, Empson V, et al
Biochem Biophys Res Commun
58
The group of epidermal nevus syndromes Part I. Well defined phenotypes
PHENOTYPEYESEPIDERMAL NEVUS SYNDROMES
https://pubmed.ncbi.nlm.nih.gov/20542174/
PROSREVIEWYES2010Rudolf HJ Am Acad Dermatol
59
The group of epidermal nevus syndromes Part II. Less well defined phenotypes
PHENOTYPEYESEPIDERMAL NEVUS SYNDROMES
https://pubmed.ncbi.nlm.nih.gov/20542175/
PROSREVIEWYES2010Rudolf HJ Am Acad Dermatol
60
Hemihyperplasia-multiple lipomatosis syndrome: an underdiagnosed entity in children with asymmetric overgrowth
PHENOTYPEYESLIPOMATOSIS
https://pubmed.ncbi.nlm.nih.gov/20105568/
PROSREVIEWYES2010
Ozlem B, Yasemin A, Aycan K, Ibrahim K
J Pediatr Surg
61
Hermann Friedberg's case report: an early description of CLOVES syndrome
PHENOTYPEYESFRIEDBERG
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0004.2010.01479.x
CLOVESCASE REPORTYES2010Ahmad IA, Thiex R, John BMClin Genet
62
Klippel-Trenaunay syndrome and spinal arteriovenous malformations: an erroneous association
PHENOTYPEYESKLIPPEL-TRENAUNAY
https://pubmed.ncbi.nlm.nih.gov/20651014/
PROSCASE REPORTYES2010Ahmad IA, Orbach DB, John BM, et alAm J Neuroradiology
63
Perinatal clinical and imaging features of CLOVES syndromeDIAGNOSISYESIMAGING
https://pubmed.ncbi.nlm.nih.gov/20155260/
CLOVESREVIEWYES2010
Fernandez-Pineda I, Fajardo M, Chaudry G, Alomari AI.
Pediatr Radiol
64
PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts
PI3KNOISOFORMS
https://www.nature.com/articles/cdd2009150
NEITHERRESEARCHYES2010Matheny RW, Jr., Adamo MLCell Death Differ
65
PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA
PI3KNOREGULATION
https://pubmed.ncbi.nlm.nih.gov/20237330/
NEITHERRESEARCHYES2010Lin RC, Weeks KL, Gao XM, et alArterioscler Thromb Vasc Biol
66
Progressive overgrowth of the cerebriform connective tissue nevus in patients with Proteus syndrome
PHENOTYPEYES
PROTEUS SYNDROME / CEREBRIFORM
https://pubmed.ncbi.nlm.nih.gov/20709429/
PROSCASE REPORTYES2010
Thomas MB, Julie CS, Leslie GB, Thomas D.
J Am Acad Dermatol
67
Syndromes with focal overgrowth in infancy: diagnostic approach and surgical treatment
DIAGNOSISYESDIAGNOSTIC APPROACH
https://pubmed.ncbi.nlm.nih.gov/21446802/
CLOVESCASE REPORTYES2010
Ursula M, Silke A, Olivia L-S, Petra M, Wolfgang S
J Plast Surg Hand Surg
68
Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis
PI3KNOBASIC RESEARCH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292322/
NEITHERRESEARCHYES2011
Mohar Chattopadhyay, Elzbieta S. Selinger, Lisa M. Ballou, Richard Z. Lin
DIABETES
69
Comments on the diagnosis and management of CLOVES syndrome
DIAGNOSISYESPERSPECTIVE
https://pubmed.ncbi.nlm.nih.gov/21504461/
CLOVESREVIEWYES2011Ahmad IAPediatr Dermatol
70
Complex spinal-paraspinal fast-flow lesions in CLOVES syndrome: analysis of clinical and imaging findings in 6 patients
PHENOTYPEYESIMAGING STUDY
http://www.ajnr.org/content/32/10/1812.long
CLOVESCASE REPORTYES2011Ahmad IA, Gulraiz C, Rodesch G, et alAm J Neuroradiology
71
Diagnosis and management of extensive vascular malformations of the lower limb: part I. Clinical diagnosis
DIAGNOSISYESLOWER LIMB
https://pubmed.ncbi.nlm.nih.gov/22000870/
PROSREVIEWYES2011Pedro R, Leyre A, Antonio M-CJ Am Acad Dermatol
72
Direct effects of rapid-acting insulin analogues on insulin signaling in human pancreatic islets in vitro
PI3KNOINSULIN
https://pubmed.ncbi.nlm.nih.gov/21354844/
NEITHERRESEARCHYES2011
D'Aleo V, Mancarella R, Del Guerra S, et al
Diabetes Metab
73
Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition
PI3KNOISOFORMS
https://pubmed.ncbi.nlm.nih.gov/21778304/
NEITHERRESEARCHYES2011
Zheng Z, Amran SI, Thompson PE, Jennings IG
Mol Pharmacol
74
A proposal for classification of entities combining vascular malformations and deregulated growth
DIAGNOSISYESPROS CLASSIFICATION
https://pubmed.ncbi.nlm.nih.gov/21356335/
PROSREVIEWYES2011
Charlène EUO, Chantal MAMvdH, Smitt JHS, et al
Embo j
75
Connective tissue nevi in children: institutional experience and review
PHENOTYPEYESCONNECTIVE TISSUE NEVI
https://pubmed.ncbi.nlm.nih.gov/22739355/
PROSCASE REPORTYES2012
Catherine CM, Caridad V, Victor K, et al
J Am Acad Dermatol
76
Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor
PI3KNOPI3K INHIBITOR
https://www.sciencedirect.com/science/article/abs/pii/S0928098712003673
NEITHERRESEARCHYES2012
Talekar M, Kendall J, Denny W, Jamieson S, Garg S
Eur J Pharm Sci.
77
Isolated macrodystrophia lipomatosa of the foot in a neonate: a case report
PHENOTYPEYESLIPOMATOSIS
https://pubmed.ncbi.nlm.nih.gov/21959860/
PROSCASE REPORTYES2012
Guzoglu N, Gokmen T, Oguz SS, Fitoz S, Dilmen U
Clin Dysmorphol
78
Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas
PI3KNOADENOCARCINOMA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854320/
NEITHERREVIEWYES2012
Murat CB, Braga PB, Fortes MA, Bronstein MD, Corrêa-Giannella ML, Giorgi RR
Braz J Med Biol Res
79
The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells
PI3KNO
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645353/
NEITHERRESEARCHYES2012Johnson AJ, Yeh YY, Smith LL, et alLeukemia
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Phenotypic progression of skeletal anomalies in CLOVES syndromePHENOTYPEYESSKELETAL ANOMALIES
https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.35383
CLOVESCASE REPORTYES2012
Klein S, Stroberg A, Ghahremani S, Martinez-Agosto JA
Am J Med Genet A
81
Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome
PHENOTYPEYESMOSAIC MUTATIONS
https://www.cell.com/ajhg/fulltext/S0002-9297(12)00262-5
CLOVESCASE REPORTYES2012Kurek KC, Luks VL, Ayturk UM, et alAm J Hum Genet
82
CLOVES syndromePHENOTYPEYESCLINICAL PHENOTYPES
https://linkinghub.elsevier.com/retrieve/pii/S0363-5023(13)01188-X
CLOVESREVIEWYES2013Jacob B, Joseph UJ Hand Surg
83
Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy.
PI3KNOPI3K INHIBITOR
https://pubmed.ncbi.nlm.nih.gov/23632263/
NEITHERRESEARCHYES2013Talekar M, Ganta S, Amiji M, et alInt J Pharm
84
Lymphatic vessel abnormalities arising from disorders of Ras signal transduction
PHENOTYPEYESRAS
https://pubmed.ncbi.nlm.nih.gov/24183794/
PROSREVIEWYES2013Eva MS-M, Philip DKTrends Cardiovasc Med
85
New findings in genodermatosesPHENOTYPEYESGENODERMATOSES
https://www.sciencedirect.com/science/article/abs/pii/S0733863512001714?via%3Dihub
CLOVESREVIEWYES2013Jonathan ADDermatol Clin
86
PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition
PI3KNOINHIBITOR
https://pubmed.ncbi.nlm.nih.gov/23439433/
NEITHERRESEARCHYES2013Conte E, Gili E, Fruciano M, et alLab Invest.
87
PIK3CA-Related Segmental OvergrowthPHENOTYPEYESOVERVIEW
https://pubmed.ncbi.nlm.nih.gov/23946963/
PROSREVIEWYES2013
Mirzaa G, Conway R, Graham JM, Jr., Dobyns WB
GeneReviews(®). Seattle (WA): University of Washington, Seattle
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Reconstructive surgery in the management of a patient with CLOVES syndrome
TREATMENTYESRECONSTRUCTIVE SURGERY
https://pubmed.ncbi.nlm.nih.gov/23867238/
CLOVESCASE REPORTYES2013
Ballieux F, Modarressi A, Hammer F, et al
J Plast Reconstr Aesthet Surg
89
Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly
PHENOTYPEYESMACRODACTYLY
https://pubmed.ncbi.nlm.nih.gov/23100325/
PROSCASE REPORTYES2013Rios JJ, Paria N, Burns DK, et alHum Mol Genet.
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Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer
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NEITHERRESEARCHYES2013
Wojtalla A, Fischer B, Kotelevets N, et al.
Clin Cancer Res
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Activating PIK3CA somatic mutation in congenital unilateral isolated muscle overgrowth of the upper extremity
PI3KNOBASIC RESEARCH
https://pubmed.ncbi.nlm.nih.gov/24975390/
NEITHERRESEARCHYES2014Castiglioni C, Bertini E, … Alvarez KAm J Hum Genet
92
Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum
PHENOTYPEYESDELINIATION OF PROS
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PROSRESEARCHYES2014
Keppler-Noreuil KM, Sapp JC, Lindhurst MJ, et al
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Cloves syndrome: a case report and perinatal diagnostic findingsDIAGNOSISYESPERINATAL
https://pubmed.ncbi.nlm.nih.gov/25365848/
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Puvabanditsin S, Memon N, Chekmareva M, Di Stefano V, Mehta R
Genet Couns
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CLOVES syndrome: a malformational syndrome closely resembling Proteus syndrome
PHENOTYPEYESCLOVES OVERVIEW
https://pubmed.ncbi.nlm.nih.gov/25209813/
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The diverse genetic landscape of neurodevelopmental disordersPHENOTYPEYESNEURODEVELOPMENT
https://pubmed.ncbi.nlm.nih.gov/25184530/
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Management of visceral vascular anomaliesTREATMENTYESVASCULAR MALFORMATIONS
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Megalencephaly syndromes: exome pipeline strategies for detecting low-level mosaic mutations
DIAGNOSISYESEXOME SEQUENCING
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908952/
CLOVESRESEARCHYES2014
William JT, Nicola F, Nicholas CPC, et al
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A Neonate with CLOVES SyndromePHENOTYPEYESNEONATE
https://www.hindawi.com/journals/cripe/2014/845074/
CLOVESCASE REPORTYES2014
Sarici D, Akin MA, Kurtoglu S, Tubas F, Sarici SU
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The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma
PI3KNOMULTIPLE MYELOMA
https://www.nature.com/articles/onc2012594
NEITHERRESEARCHYES2014
Munugalavadla V, Mariathasan S, Slaga D, et al.
Oncogene
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PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2
PI3KNOCELL SURVIVAL
https://pubmed.ncbi.nlm.nih.gov/24645666/
NEITHERRESEARCHYES2014
Wahane SD, Hellbach N, Prentzell MT, et al
J Neurochem