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dat.onderzoek octamethylcyclotetrasiloxane D4concl.
onderzoekers
kort/lang termijn studie
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1995Induction of type II collagen arthritis in the DA rat using silicone gels and oils as adjuvant.
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1995The effect of molecular weight and gel preparation on humoral adjuvancy of silicone oils and silicone gels.
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1996The adjuvancy of silicones: dependency on compartmentalization.Dow CorningIn short (10 day) and long (180 day) term gel implant studies,
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1996Silicone gel and octamethylcyclotetrasiloxane potentiate antibody production to bovine serum albumin in mice.
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1996Cytotoxicity and membrane damage in vitro by inclusion complexes between gamma-cyclodextrin and siloxanes.
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1996Silicone gel and octamethylcyclotetrasiloxane (D4) enhances antibody production to bovine serum albumin in mice.
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1997Protein denaturation induced by cyclic silicone.
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1998Extraction of octamethylcyclotetrasiloxane and its metabolites from biological matrices.Dow Corning
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1998Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.at 9, 12, and 15 weeks
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1998
Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study.
Dow Corningexposure days 3, 7, 14, 21, and 28
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1998Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor.10, 20, and 10 min 10ppm inhalation
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1998Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects.10 ppm D4 or air for 1 h via a mouthpiece
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1999Cyclosiloxanes produce fatal liver and lung damage in mice.all the mice injected with 35 g/kg died within 5-8 days.
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1999Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine.Dow Corning
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1999Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats.Dow Corning
28 day whole body vapor inhalation study 6 hours/day, 5 days/week
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2000Genetic toxicity evaluation of octamethylcyclotetrasiloxane.
Union Carbide
6 hr daily for 5 days ,in vitro
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2001
Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.
Dow Corning0 ppm D4, 700 ppm D4 vapors (6 h/day; 5 days/week)
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2001
Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay.
Dow Corningonce a day for 4 consecutive days
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2001The transport of octamethylcyclotetrasiloxane (D4) and polydimethylsiloxane (PDMS) in lightly cross-linked silicone rubber.
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2001Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.
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2002Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats.6 h/day, 5 days/week for 3 months
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2002The effect of cyclic swelling (octamethylcyclotetrasiloxane) on the physical properties of silicone breast implant shells.
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2002Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.6 h/day, 5-day inhalation exposure
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2002Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model.24 hr
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2002Bioavailability of D4 after inhalation and implantation exposure to silicones.Dow Corning
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2002Further comments on the bioavailability of D4.
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2003Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models.
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2003Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.
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2003PBPK modeling advances understanding of D4 pharmacokinetics.
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2003Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.
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2003Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.
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2007In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes.Dow Corning
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2007A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation.
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2007An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens.Dow Corning
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2007
Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats.
Dow Corning
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2008Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humans.
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2008In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).Dow Corning
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2008Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.
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2008Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
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2013Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).personal care
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in totaal 110 onderzoeken te vinden op NBCI/pubmed de rest van de onderzoeken heeft betrekking op milieu en chemie etc
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gezocht op decamethylcyclopentasiloxane (D5)
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1998Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.3, 6, or 9 weeks organs.. harvested at 9, 12, and 15 weeks
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1998Toxicology and humoral immunity assessment of decamethylcyclopentasiloxane (D5) following a 1-month whole body inhalation exposure in Fischer 344 rats.Dow Corninginhalation to 0, 10, 25, 75, or 160 ppm D5 6 h/day, 7 days/week for 28 days
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1998Inhalation toxicology of decamethylcyclopentasiloxane (D5) following a 3-month nose-only exposure in Fischer 344 rats.Dow Corning6 h/day, 5 days/week for 3 months
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1999Cyclosiloxanes produce fatal liver and lung damage in mice.injected with 35 g/kg died within 5-8 days
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1999Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5).Dow Corning6 h/day, 7 days/week, for 28 days)
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1999Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats.Dow Corning
28 day 7, 20, 60, 180 and 540 ppm for 6 hours/day, 5 days/week
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2000Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes.
1, 5, 20, or 100 mg/kg D4 or D5 in corn oil daily by gavage for 4 days
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2001Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.breast implants
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2003Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in Fischer 344 rat urine--a comparison of a linear and a cyclic siloxane.Dow Corning
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2003Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.breast implants
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2003The measurement of conformational stability of proteins adsorbed on siloxanes.24-h incubation with siloxanes
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2003Highly activated, silicone entrapped, lipase.
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2003Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.
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2007A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation.Dow Corning
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2007In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes.Dow Corning
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2007Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).through axilla skin
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2007In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).Dow Corningskin absorption
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2008Disposition of decamethylcyclopentasiloxane in Fischer 344 rats following single or repeated inhalation exposure to 14C-decamethylcyclopentasiloxane (14C-D5).Dow Corninginhalation
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2008Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products.
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2008Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
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2008Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.
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2009Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.personal care
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2013Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).personal care
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In totaal 73 onderzoeken D5 waarvan bovenstaande betrekking hadden aan blootstelling de rest was o.a. milieu gevolgen
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