[NORC OpenData]-Nipah Virus Inhibitor Collection
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1
IDInhibitorName
PubChemID
Drug BAnk ID
SMILESMolWtTargetAssayType
Assay Description
AssaySourceAssay CellTypeOutcomeINactive
IC50 [uM]
IC50[nM]
EC50[uM]
EC[nM]
in vivo testing performed?
ReferencePMID/DOIAnnotatorEmail
2
NVIC0001GS-441524
RNA dependent RNA Polymerase
FIPV Replication assay
qRT-PCR
GS-441524 - provided by Gilead Sciences, Inc
Crandell-Rees Feline Kidney (CRFK) cells
suppression of viral RNA expression
0.49 to 1
https://www.sciencedirect.com/science/article/pii/S0378113518301603?via%3Dihub
29778200anshu@imtech.res.in
3
NVIC0002GS-5734121304016
CCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
602.585 g/mol0.49 to 128262699anshu@imtech.res.in
4
NVIC0003R1479457388
C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
284.232 g/mol4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954062/
29765101anshu@imtech.res.in
5
NVIC0004Favipiravir492405
C1=C(N=C(C(=O)N1)C(=O)N)F
157.104 g/mol
RNA dependent RNA Polymerase
Virus yield reduction assay
Plaque assay
Favipiravir provided by Toyama Chemical Company Ltd
Vero CCL81NiV-M44.24
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954062/
29765101anshu@imtech.res.in
6
NVIC0005Favipiravir492405
C1=C(N=C(C(=O)N1)C(=O)N)F
157.104 g/mol
RNA dependent RNA Polymerase
Virus yield reduction assay
Plaque assay
Favipiravir provided by Toyama Chemical Company Ltd
Vero CCL81NiV-B14.82
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954062/
29765101anshu@imtech.res.in
7
NVIC0006Favipiravir492405
C1=C(N=C(C(=O)N1)C(=O)N)F
157.104 g/mol
RNA dependent RNA Polymerase
Virus yield reduction assay
Plaque assay
Favipiravir provided by Toyama Chemical Company Ltd
Vero CCL81rNiV-Gluc-eGFP14.47
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954062/
29765101anshu@imtech.res.in
8
NVIC0007
ethyl 4-[3-[(2,4-dichlorophenyl)methylcarbamoyl]-1-ethyl-6-fluoro-4-oxoquinolin-7-yl]piperazine-1-carboxylate
44191025
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C(=O)OCC)F)C(=O)NCC4=C(C=C(C=C4)Cl)Cl
549.424 g/mol
glycoprotein G
NiV and measles virus (MV) envelope protein-based fusion assay
https://pubchem.ncbi.nlm.nih.gov/bioassay/420714#section=Source
4
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921anshu@imtech.res.in
9
NVIC0008
ethyl 1-[3-[(2,4-dichlorophenyl)methylcarbamoyl]-1-ethyl-6-fluoro-4-oxoquinolin-7-yl]piperidine-4-carboxylate
44191024
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCC(CC3)C(=O)OCC)F)C(=O)NCC4=C(C=C(C=C4)Cl)Cl
548.436 g/mol
glycoprotein G
NiV and measles virus (MV) envelope protein-based fusion assay
https://pubchem.ncbi.nlm.nih.gov/bioassay/420714#section=Source
3
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921anshu@imtech.res.in
10
NVIC0009
ethyl 4-[1-cyclopropyl-3-[(2,4-dichlorophenyl)methylcarbamoyl]-6-fluoro-4-oxoquinolin-7-yl]piperazine-1-carboxylate
44191117
CCOC(=O)N1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)NCC4=C(C=C(C=C4)Cl)Cl)C5CC5)F
561.435 g/mol
glycoprotein G
NiV and measles virus (MV) envelope protein-based fusion assay
https://pubchem.ncbi.nlm.nih.gov/bioassay/420714#section=Source
3
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921anshu@imtech.res.in
11
NVIC0010
7-(4-carbamoylpiperidin-1-yl)-1-cyclopropyl-N-[(2,4-dichlorophenyl)methyl]-6-fluoro-4-oxoquinoline-3-carboxamide
44191023
C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCC(CC4)C(=O)N)F)C(=O)NCC5=C(C=C(C=C5)Cl)Cl
531.409 g/mol
glycoprotein G
NiV and measles virus (MV) envelope protein-based fusion assay
https://pubchem.ncbi.nlm.nih.gov/bioassay/420714#section=Source
1.5
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921anshu@imtech.res.in
12
NVIC0011
N-(Cyclopropylmethyl)-1-ethyl-6-fluoro-4-oxo1,4- N-(4-Chlorobenzyl)-1-ethyl-4-oxo-7-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide
protein cavity in the F protein
CPE basedVero cells
preventing membrane fusion
>8
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921kanikatuteja@gmail.com
13
NVIC0012
4-oxo-1,4-Dihydroquinoline-3,5-dicarboxylic Acid
protein cavity in the F protein
CPE basedVero cells
preventing membrane fusion
8
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921kanikatuteja@gmail.com
14
NVIC0013
4-oxo-1,4-Dihydroquinoline-3,7-dicarboxylic Acid
protein cavity in the F protein
CPE basedVero cells
preventing membrane fusion
8
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921kanikatuteja@gmail.com
15
NVIC0014
diethyl (2R,6S)-1-allyl-4-hydroxy-2,6-bis(4-nitrophenyl)-1,2,3,6-tetrahydropyridine-3,5-dicarboxylate
protein cavity in the F protein
CPE basedVero cells
preventing membrane fusion
Inactive>20
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921kanikatuteja@gmail.com
16
NVIC0015
2-benzylbenzooxazol-5-yl-ammonium chloride
protein cavity in the F protein
CPE basedVero cells
preventing membrane fusion
Inactive>8
J Med Chem. 2009 Jul 23;52(14):4257-65
19499921kanikatuteja@gmail.com
17
NVIC0016Capped NiV FC2Peptide
cell-cell fusion assays
VeroNiV13.08
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
18
NVIC0017N-PEG NiV FC2 Peptide
cell-cell fusion assays
VeroNiV3.66
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
19
NVIC0018C-PEG NiV FC2 Peptide
cell-cell fusion assays
VeroNiV98.05
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
20
NVIC0019Capped NiV FC2Peptide
cell-cell fusion assays
U373NiV16.28
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
21
NVIC0020N-PEG NiV FC2 Peptide
cell-cell fusion assays
U373NiV4.85
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
22
NVIC0021C-PEG NiV FC2 Peptide
cell-cell fusion assays
U373NiV79.19
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
23
NVIC0022Capped NiV FC2Peptide
cell-cell fusion assays
PCI 13NiV17.79
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
24
NVIC0023N-PEG NiV FC2 Peptide
cell-cell fusion assays
PCI 13NiV5.04
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
25
NVIC0024C-PEG NiV FC2 Peptide
cell-cell fusion assays
PCI 13NiV93.32
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
26
NVIC0025Capped NiV FC2Peptide
virus infection assays
immunofluorescence infection assay
VeroNiV11.42
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
27
NVIC0026N-PEG NiV FC2Peptide
virus infection assays
immunofluorescence infection assay
VeroNiV1.36
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
28
NVIC0027C-PEG NiV FC2Peptide
virus infection assays
immunofluorescence infection assay
VeroNiV43.76
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
29
NVIC0028Capped NiV FC2Peptide
virus infection assays
immunofluorescence infection assay
PCI 13NiV2.7
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
30
NVIC0029N-PEG NiV FC2Peptide
virus infection assays
immunofluorescence infection assay
PCI 13NiV1.26
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
31
NVIC0030C-PEG NiV FC2Peptide
virus infection assays
immunofluorescence infection assay
PCI 13NiV55.75
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-57
16026621kanikatuteja@gmail.com
32
NVIC0031
VIKI-dPEG4-Chol and VIKI-dPEG4-Toco
Peptide
Plasma Membrane
Cell-Cell fusion
NiV glycoproteins
1
https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiy152/4939224?redirectedFrom=PDF
29566184kanikatuteja@gmail.com
33
NVIC0032VIKI-dPEG4Peptide
Plasma Membrane
Cell-Cell fusion
NiV glycoproteins
7
https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiy152/4939224?redirectedFrom=PDF
29566184kanikatuteja@gmail.com
34
NVIC0033Galectin-1ProteinNiV-F
NiV mediated endothelial cell fusion
NiV
http://www.jimmunol.org/content/182/1_Supplement/128.3
kanikatuteja@gmail.com
35
NVIC0034AB00991123
C1CC(=CC2=CC=CC=C21)S(=O)(=O)NC3=CC=C(C=C3)N4C=NN=N4
353.4 g/mol
CPE-based assays
Southern Research Institute
Vero CellsNiV3.9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994909/
24735442kanikatuteja@gmail.com
36
NVIC0035AB009923918189728
C1=CC(=CC=C1NS(=O)(=O)C2=CC(=C(C=C2)F)F)N3C=NN=N3
337.305 g/mol
CPE-based assays
Southern Research Institute
Vero CellsNiV11.7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994909/
24735442kanikatuteja@gmail.com
37
NVIC0036AB0099321025661567
CN(C)S(=O)(=O)C1=CC2=C(C=C1)N(CC2)S(=O)(=O)C3=CC(=CC=C3)Cl
400.892 g/mol
CPE-based assays
Southern Research Institute
Vero CellsNiV7.8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994909/
24735442kanikatuteja@gmail.com
38
NVIC0037 R1479 457388
C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
284.232 g/mol
RdRp complex
immunofluorescence assay
CPE inhibition assay
NCI-H358 cells NiV 2.63
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
28629988kanikatuteja@gmail.com
39
NVIC0038 R1479 457388
C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
284.232 g/mol
RdRp complex
Virus Titre Reduction assay
CPE inhibition assay
HeLaNiV 13.55
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
28629988kanikatuteja@gmail.com
40
NVIC0039R1479457388
C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
284.232 g/mol
RdRp complex
Virus titer reduction (VTR) assays
NCI-H358 cells. NiV 1.53
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648002/
28629988kanikatuteja@gmail.com
41
NVIC0040VIKI-PEG4-chol PeptidemembraneCell fusion
HPIV3 glycoproteins F and HN
NiV30
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001168
21060819kanikatuteja@gmail.com
42
NVIC0041 2'diF-4'N3-C
nucleoside analog of R1479
29601894kanikatuteja@gmail.com
43
NVIC00422'F-4'N3-C
nucleoside analog of R1479
29601894kanikatuteja@gmail.com
44
NVIC0043 Poly(I)-poly(C12U)16131547
C1CC(OC1CO)N2C=NC3=C2N=CNC3=O.C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)OP(=O)(O)OCC3C(C(C(O3)N4C=CC(=NC4=O)N)O)OP(=O)(O)OCC5C(C(C(O5)N6C=CC(=NC6=O)N)O)OP(=O)(O)OCC7C(C(C(O7)N8C=CC(=NC8=O)N)O)OP(=O)(O)OCC9C(C(C(O9)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=NC1=O)N)O)OP(=O)(O)OCC1C(C(C(O1)N1C=CC(=O)NC1=O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)OC4C(OC(C4O)N5C=NC6=C5N=CNC6=O)COP(=O)(O)OC7C(OC(C7O)N8C=NC9=C8N=CNC9=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)OC1C(OC(C1O)N1C=NC2=C1N=CNC2=O)COP(=O)(O)O)O)O
8533.127 g/mol
ReplicationCPE Assay
K. B. Chua and S. Kim Lam (Kuala Lumpur, Malaysia)
HeLa cells NiV6.25
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
45
NVIC0044C-c3 Ado72501
C1C(C(C(C1N2C=NC3=C2C=CN=C3N)O)O)CO
264.285 g/molReplicationCPE AssayVero E6 cellsNiVInactive>8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
46
NVIC0045(−)-5′ Noraristeromycin126704
C1C(C(C(C1O)O)O)N2C=NC3=C2N=CN=C3N
251.246 g/molReplicationCPE AssayVero E6 cellsNiVInactive>4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
47
NVIC0046DHCaA73651
C1CC(C(C1N2C=NC3=C2N=CN=C3N)O)O
235.247 g/molReplicationCPE AssayVero E6 cellsNiVInactive>4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
48
NVIC0047Ribavirin37542
C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
244.207 g/molCPE AssayVero E6 cellsNiV100
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
49
NVIC0048EICAR453180
C#CC1=C(N=CN1C2C(C(C(O2)CO)O)O)C(=O)N
267.241 g/molCPE AssayVero E6 cellsNiV1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
50
NVIC0049Pyrazofurin35595
C(C1C(C(C(O1)C2=C(C(=NN2)C(=O)N)O)O)O)O
259.218 g/molCPE AssayNiV0.125
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
51
NVIC0050Carbodine459903
C1C(C(C(C1N2C=CC(=NC2=O)N)O)O)CO
241.247 g/molCPE AssayVero E6 cellsNiVInactive>8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
52
NVIC00516-Aza-uridine5901
C1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
245.191 g/molCPE AssayVero E6 cellsNiV0.25
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472238/
16641448kanikatuteja@gmail.com
53
NVIC0052Gliotoxin6223
CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O
326.385 g/mol
Monolayer based Assay
Vero CellsNiV149
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781006/
19889218kanikatuteja@gmail.com
54
NVIC0053Gentian Violet11057
CN(C)C1=CC=C(C=C1)C(=C2C=CC(=[N+](C)C)C=C2)C3=CC=C(C=C3)N(C)C.[Cl-]
407.986 g/mol
Monolayer based Assay
Vero CellsNiV525
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781006/
19889218kanikatuteja@gmail.com
55
NVIC0054Brilliant Green12449
CCN(CC)C1=CC=C(C=C1)C(=C2C=CC(=[N+](CC)CC)C=C2)C3=CC=CC=C3.OS(=O)(=O)[O-]
482.639 g/mol
Monolayer based Assay
Vero CellsNiV218
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781006/
19889218kanikatuteja@gmail.com
56
NVIC0055Ribavirin37542
C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
244.207 g/mol
https://www.ncbi.nlm.nih.gov/pubmed/11409437
11409437kanikatuteja@gmail.com
57
NVIC0056m102.4Antibody
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000642
19888339kanikatuteja@gmail.com
58
NVIC0057 Galectin-1 Protein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325760/
25505064kanikatuteja@gmail.com
59
NVIC0058TetherinProteinNiV
https://www.ncbi.nlm.nih.gov/pubmed/23077864
23077864kanikatuteja@gmail.com
60
NVIC0059bortezomib387447
B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
384.243 g/mol
NiV-M nuclear export
2.7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978725/
21085610kanikatuteja@gmail.com
61
NVIC0060MG132462382
CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
475.63 g/mol
NiV-M nuclear export
0.47
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978725/
21085610kanikatuteja@gmail.com
62
NVIC0061HPIVP3
cholesterol tagged monomer
plaque reduction assays
NiV 8.02
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353973/
22666328kanikatuteja@gmail.com
63
NVIC0062 HPIV-P4
cholesterol tagged dimer
plaque reduction assays
NiV 4.36
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353973/
22666328kanikatuteja@gmail.com
64
NVIC0063A2318740486
CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
523.63 g/molNiV0.07
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910441/
20668647kanikatuteja@gmail.com
65
NVIC0064 HPIV3-derived peptidepeptide
plaque enlargement assay
NiV0.25
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045485/
17652384kanikatuteja@gmail.com
66
NVIC0065FC2peptidepeptide
plaque enlargement assay
NiV11.4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045485/
17652384kanikatuteja@gmail.com
67
NVIC0066IFN-λ InterferonPolymeraseNiV28984239kanikatuteja@gmail.com
68
NVIC0067GYY413746937262
COC1=CC=C(C=C1)P(=S)(N2CCOCC2)S
289.348 g/molSAE cells
inhibited syncytium formation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442521/
25740991
nishisharmacool14@gmail.com
69
NVIC0068
20-deoxy-20-fluorocytidine
Minigenome screen assay
Selleckchem (Houston, TX, USA) or Sigma-Aldrich (Saint Louis, MO, USA)
Huh7 cells
NiV and other paramyxoviruses
1.48
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862516/
29522528kanikatuteja@gmail.com
70
NVIC0069Mycophenolic acid446541
CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)O)OC
320.341 g/mol
Minigenome screen assay
Selleckchem (Houston, TX, USA) or Sigma-Aldrich (Saint Louis, MO, USA)
Huh7 cells
NiV and other paramyxoviruses
0.33
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862516/
29522528kanikatuteja@gmail.com
71
NVIC00706-azauridine5901
C1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
245.191 g/mol
Minigenome screen assay
Selleckchem (Houston, TX, USA) or Sigma-Aldrich (Saint Louis, MO, USA)
Huh7 cells
NiV and other paramyxoviruses
7.99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862516/
29522528kanikatuteja@gmail.com
72
NVIC007191679167
C1=CC=C2C=C3C=C4C5=CC=CC=C5C6=CC=CC=C6C4=CC3=CC2=C1
328.414 g/mol
(Vitas-M Laboratory, Champaign, IL, USA
0.67
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862516/
29522528kanikatuteja@gmail.com
73
NVIC0072OSU-0301210027278
C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F
460.46 g/molLuc reporter293TNiV-Luc0.4
https://www.sciencedirect.com/science/article/pii/S0166354215001126?via%3Dihub
25986249kanikatuteja@gmail.com
74
NVIC00736-Azauridine acetate
pyrimidine biosynthesis
CPE-based assay
293T cellsNiV-LUC2AM0.274
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
75
NVIC00746-Azauridine acetate
pyrimidine biosynthesis
CPE-based assay
293T cellsNiV-GFP2AM0.553
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
76
NVIC00756-Azauridine acetate
pyrimidine biosynthesis
CPE-based assay
293T cellsNiV-MY-990.12
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
77
NVIC0076Pyrazofurin35595
C(C1C(C(C(O1)C2=C(C(=NN2)C(=O)N)O)O)O)O
259.218 g/mol
pyrimidine biosynthesis
CPE-based assay
293T cellsNiV-LUC2AM0.432
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
78
NVIC0077Pyrazofurin35595
C(C1C(C(C(O1)C2=C(C(=NN2)C(=O)N)O)O)O)O
259.218 g/mol
pyrimidine biosynthesis
CPE-based assay
293T cellsNiV-GFP2AM0.281
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
79
NVIC007891679167
C1=CC=C2C=C3C=C4C5=CC=CC=C5C6=CC=CC=C6C4=CC3=CC2=C1
328.414 g/molNiV-LUC2AM0.0723
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
80
NVIC007991679167
C1=CC=C2C=C3C=C4C5=CC=CC=C5C6=CC=CC=C6C4=CC3=CC2=C1
328.414 g/molNiV-GFP2AM0.254
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
81
NVIC008091679167
C1=CC=C2C=C3C=C4C5=CC=CC=C5C6=CC=CC=C6C4=CC3=CC2=C1
328.414 g/molNiV-MY-990.0289
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100748/
24680955kanikatuteja@gmail.com
82
NVIC0081NiV-Fc2peptide
HR1 or HR2 domains of a viral fusion protein
blocking 6 HB formation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315217/
22470837
nishisharmacool14@gmail.com
83
NVIC0082mAb (m102.4) antibody
F & G glycoprotein
ferret model yes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315217/
22470837
nishisharmacool14@gmail.com
84
NVIC00835705213cathepsin L293FT cells
https://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+a+Broad-Spectrum+Antiviral+Small+Molecule+against+Severe+Acute+Respiratory+Syndrome+Coronavirus+and+Ebola%2C+Hendra%2C+and+Nipah+Viruses+by+Using+a+Novel+High-Throughput+Screening+Assay
24501399
nishisharmacool14@gmail.com
85
NVIC008474026837402683
COC1=CC=C(C=C1)NC(=O)NC2CC3CCC(C2)[NH+]3CC4=CC=CO4
356.446 g/molcathepsin L293FT cells
https://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+a+Broad-Spectrum+Antiviral+Small+Molecule+against+Severe+Acute+Respiratory+Syndrome+Coronavirus+and+Ebola%2C+Hendra%2C+and+Nipah+Viruses+by+Using+a+Novel+High-Throughput+Screening+Assay
24501399
nishisharmacool14@gmail.com
86
NVIC0085ribavirin37542
C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
244.207 g/mol
RNA-dependent RNA polymerase complex
block virus replication through error catastrophe
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428208/
26029193
nishisharmacool14@gmail.com
87
NVIC0086RSV604 5279172
C1=CC=C(C=C1)C2=NC(C(=O)NC3=CC=CC=C32)NC(=O)NC4=CC=CC=C4F
388.402 g/mol
targeting protein interfaces such as those between N and P, P and L, P and P, or L and L
block paramyxovirus RdRp
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428208/
26029193
nishisharmacool14@gmail.com
88
NVIC0087
Quinacrinedihydrochloridedihydrate
508.93.08
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
89
NVIC0088clemastine4604.78
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
90
NVIC0089CER0144654315.41.33
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
91
NVIC009032290951391.41.51
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
92
NVIC009184801158480115
C1CCC(CC1)NC(=S)N2CCN(CC2)C(=O)C3=CC=CC=C3Cl
349.3
365.92 g/mol
1.64
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
93
NVIC00921926228119262281
CCN1C=CC(=N1)C(=O)NC2=CN(N=C2C(=O)N)CC
383.4
276.3 g/mol
1.7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
94
NVIC00931013040610130406
[Li+].[F-].[F-].[F-].[Ba+2]
376.4
201.262 g/mol
1.73
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
95
NVIC009432290947446.52.05
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
96
NVIC0095
CHLOROQUINE DIPHOSPHATE
515.92.65
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
97
NVIC009616114804514.43.1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
98
NVIC009715930009414.54.58
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
99
NVIC00989290114250.35.56
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
19264786
nishisharmacool14@gmail.com
100
NVIC0099AAHL7
NOVEL compound
HTS Immunolabeling assay
non-linear regression analysis
HeLa cells6612
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744099/
19428741
nishisharmacool14@gmail.com
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