| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | AA | |
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1 | id | name | CPX name | symbol | name_synonyms | symbol_synonyms | description | genes | refs | GO_CC | GO_BP | GO_MF | FB Checked difference ok? | Make Xref in FB for FB2022_05? | For FB_2022_06 | Make records for FB2023 release: template https://docs.google.com/spreadsheets/d/1TOU1cMEaW-I1jXKjgL5t0xxP09L8Hck1Hi2RYmRqi14/edit#gid=0 | FB2024_04 | ||||||||||
2 | FBgg0001641 | CPX-2830 | 7SK SMALL NUCLEAR RIBONUCLEOPROTEIN | 7SKRNP | - | 7SK snRNP | 7SK small nuclear ribonucleoprotein (7SK snRNP) plays a central role in RNA polymerase II elongation control by sequestering positive transcription elongation factor complex b (P-TEFb) and therefore regulating the availability of active P-TEFb. (Adapted from PMID:28431135.) | Q7K480,Q8INF6,Q9W362,URS00007F2EC7_7227 | 22379134,21262214 | 7SK snRNP ; GO:0120259 | negative regulation of transcription elongation from RNA polymerase II promoter ; GO:0034244 | P-TEFb complex binding ; GO:0106140 | Y | ||||||||||||||
3 | FBgg0000297 | CPX-2829 | ACF COMPLEX | ACF chromatin remodeling complex | ACF | Acf1-ISWI complex|ATP-dependent chromatin-assembly factor|ATP-utilizing chromatin assembly and remodeling factor | - | ACF is an ISWI-containing chromatin remodeling complex that optimizes nucleosome spacing to promote chromatin assembly. (Adapted from FBrf0228920). | Q9V9T4,Q24368 | 16821138,19355820,10385622 | ACF complex ; GO:0016590 | nucleosome mobilization ; GO:0042766 | ATP-dependent chromatin remodeler activity ; GO:0140658 | Y | |||||||||||||
4 | FBgg0001737 | CPX-2828 | F-ACTIN CAPPING PROTEIN COMPLEX | ACPC | - | - | The F-actin capping protein complex is a heterodimer which regulates actin polymerization. The complex binds to the plus (barbed) end of actin filaments and blocks the exchange of actin monomers. (Adapted from FBrf0213674 and FBrf0224864). | Q9W2N0,P48603 | 24788460,21525075 | F-actin capping protein complex ; GO:0008290 | barbed-end actin filament capping ; GO:0051016 | - | Y | ||||||||||||||
5 | FBgg0001747 | CPX-2824 | ADA COMPLEX | ADAC | Ada2/Gcn5/Ada3 transcription activator (ADA) complex | - | The Ada2/Gcn5/Ada3 transcription activator (ADA) complex is a Gcn5-containing histone acetyltransferase complex that regulates transcription by acetylating core histones, preferentially histone H3 and nucleosomal substrates. (Adapted from FBrf0242086, FBrf0247978 and FBrf0248705). | Q8I8V0-1,M9PHZ1,Q9VTZ1,Q9W2I4 | 32739556,30715476,32735945 | ADA complex ; GO:0140671 | histone acetylation ; GO:0016573 | histone acetyltransferase activity ; GO:0004402 | Y | Y | |||||||||||||
6 | FBgg0000145 | CPX-2510 | ADAPTOR PROTEIN COMPLEX 1 | Adaptor complex AP-1 | AP1 | Adaptin 1|AP-1 adaptor complex | AP-1 | Adaptor protein (AP) complexes select cargo for inclusion into clathrin coated vesicles in the late secretory and endocytic pathways. AP-1 is specific for trafficking between the trans-Golgi network and endosomes. (Adapted from PMID:10611976 and PMID:15066634). | Q24253,Q7KVR8,O62531,B8A403 | 11598180 | AP-1 adaptor complex ; GO:0030121 | vesicle-mediated transport ; GO:0016192 | clathrin adaptor activity ; GO:0035615 | Y | |||||||||||||
7 | FBgg0000161 | CPX-2725 | ADAPTOR PROTEIN COMPLEX 2 | Adaptor complex AP-2 | AP2 | Adaptin 2|AP-2 adaptor complex | AP-2 | Adaptor protein (AP) complexes select cargo for inclusion into clathrin coated vesicles in the late secretory and endocytic pathways. AP-2 is involved in plasma membrane to endosome traffic. (Adapted from PMID:10611976 and PMID:15066634). | Q24253,P91926,O62530,Q9VDC3 | 11598180 | AP-2 adaptor complex ; GO:0030122 | vesicle-mediated transport ; GO:0016192 | clathrin adaptor activity ; GO:0035615 | Y | |||||||||||||
8 | FBgg0000136 | CPX-2727 | ADAPTOR PROTEIN COMPLEX 3 | Adaptor complex AP-2 | AP3 | Adaptin 3|AP-3 adaptor complex | AP-3 | Adaptor protein (AP) complexes select cargo for inclusion into coated vesicles in the late secretory and endocytic pathways. AP complexes are heterotetramers. AP-3 is associated with endosomes and, to a less extent, the trans-Golgi network and appears to function independently of clathrin. Drosophila AP-3 genes were first linked to defects in the biogenesis of visual pigment granules. (Adapted from FBrf0129983 and PMID:15066634). | O76928,P54362,Q9W1E8,Q9W4K1 | 11598180 | AP-3 adaptor complex ; GO:0030123 | ommochrome biosynthetic process ; GO:0006727|vesicle-mediated transport ; GO:0016192 | - | Y | |||||||||||||
9 | FBgg0000074 | CPX-2728 | ANAPHASE-PROMOTING COMPLEX | APC | Anaphase-promoting complex/cyclosome|Anaphase promoting complex|APC-Cdc20 complex|Cyclosome | APC/C | Anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase. Active during mitosis and G1 phases of the cell cycle, it mediates the degradation of cyclins and other key cell cycle regulators triggering the metaphase to anaphase transition and the exit from mitosis. (Adapted from PMID:12208841). | Q9W395,Q9W3Y6,Q9V831,Q9VCN6,Q9I7L8,Q9VS37,Q9W4H9,Q24044,Q9VZL2,Q7KA43,Q9W1E5,Q9VXV3 | 12208841,17878237 | anaphase-promoting complex ; GO:0005680 | anaphase-promoting complex-dependent catabolic process ; GO:0031145|positive regulation of mitotic metaphase/anaphase transition ; GO:0045842 | ubiquitin protein ligase activity ; GO:0061630 | Y | ||||||||||||||
10 | FBgg0000129 | CPX-2729 | APOPTOSOME | APOP | - | - | The apoptosome is a ring-like multisubunit complex assembled upon receiving a pro-apoptotic signal. In Drosophila, Dark assembles into two stacked rings of eight subunits each. This scaffold binds ADP and an initiator caspase (Dronc in D.mel) which cleaves effector caspase(s). (Adapted from FBrf0212736). | Q7KLI1,Q9XYF4 | 23561633,21220123 | apoptosome ; GO:0043293 | activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ; GO:0097297 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway ; GO:0097199 | Y | ||||||||||||||
11 | FBgg0001553 | CPX-2732 | ALTERNATIVE siRNA RISC-LOADING COMPLEX | siRNA RISC-loading complex, loqs variant | aRLC | Alternative short interfering RNA-RNA-induced silencing complex loading complex | - | The alternative siRNA-RISC loading complex (aRLC) has been characterised in S2 cells. In the aRLC, loqs replaces r2d2 as the double-stranded RNA-binding domain-containing protein. siRNA RISC-loading complex binds small interfering RNAs (siRNAs) siRNA and loads it onto AGO2 to form RNA-induced silencing complexes (RISCs). (Adapted from FBrf0237457.) | Q9VUQ5,Q95YG3,Q9VJY9 | 29040648 | RISC-loading complex ; GO:0070578 | small RNA loading onto RISC ; GO:0070922 | - | Y | |||||||||||||
12 | FBgg0000158 | CPX-2739 | ACTIN-RELATED PROTEIN 2/3 COMPLEX ARPC3A VARIANT | ARPC3A | - | ARP-2/3 | The Actin-related protein 2/3 complex is involved in the organization of the actin cytoskeleton, in particular, the nucleation of branched actin filaments. (Adapted from FBrf0144947). | P45888,P32392,O97182,Q9VIM5,Q9VF28,Q9VX82,Q9VMH2,Q9VQD8 | 14757065,11854308 | Arp2/3 protein complex ; GO:0005885 | Arp2/3 complex-mediated actin nucleation ; GO:0034314 | actin binding ; GO:0003779|structural constituent of cytoskeleton ; GO:0005200 | made separate flavours of ARPC for FB; changed symbol to ARPC3A | N | Y | ||||||||||||
13 | FBgg0001796 | CPX-2589 | ACTIN-RELATED PROTEIN 2/3 COMPLEX ARPC3B VARIANT | ARPC3B | P45888,P32392,O97182,Q9VIM5,Q9VF28,Q9VX82,Q9VMH2,Q9VQD8 | made separate flavours of ARPC for FB | N | Y | |||||||||||||||||||
14 | FBgg0000138 | CPX-2742 | ATAC COMPLEX | ATAC histone acetyltransferase complex | ATAC | Ada2a-containing complex|Ada2/Gcn5/Ada3 transcription activator complex | - | The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126). | Q7KSD8,M9PHZ1,Q9VM59,Q9VJ73,M9NFF9,Q9V444,Q9VLL1,Q9VTZ1,Q9V4C8,Q9VBX2,Q9VJQ5,Q9W2I4,Q9V3J8 | 22426530,18327268,22345504 | ATAC complex ; GO:0140672 | histone acetylation ; GO:0016573 | histone acetyltransferase activity ; GO:0004402 | Y | |||||||||||||
15 | FBgg0000199 | CPX-2743 | ATG12-ATG5-ATG16 COMPLEX | ATG-C | - | - | The Atg12-Atg5-Atg16 complex is needed for autophagosome formation. It is composed of Atg16 interacting with covalently linked Atg12-Atg5. (Adapted from PMID:23321721 and PMID:23999079). | Q9W3R7,Q9VTU1,B7Z0R7 | 20798940 | Atg12-Atg5-Atg16 complex ; GO:0034274 | autophagy ; GO:0006914 | - | Y | ||||||||||||||
16 | FBgg0000217 | CPX-2744 | AUTOPHAGY-SPECIFIC PHOSPHATIDYLINOSITOL 3-KINASE COMPLEX | Phosphatidylinositol 3-kinase complex, class III, ATG14 variant | ATG-PI3K | Autophagy-specific PI 3-kinase complex|Class III phosphatidylinositol 3-kinase complex type I|PtdIns-3-kinase complex I | - | The autophagy-specific phosphatidylinositol 3-kinase complex generates PI3-phosphate (PI3P) at the PAS (phagophore assembly site/preautophagosomal structure). (Adapted from FBrf0219844 and PMID:23999079). | Q9VCE1,Q9VAP6,Q9W1M7,Q9VHH2 | 22562043 | phosphatidylinositol 3-kinase complex, class III, type I ; GO:0034271 | autophagy ; GO:0006914 | - | Y | |||||||||||||
17 | FBgg0000132 | CPX-2745 | ATG1 PROTEIN KINASE COMPLEX | ATG-PK | ATG1-ATG13 kinase complex|Atg1 complex|autophagy-related 1 complex|UKL1 complex | - | The Atg1 protein kinase complex, is an autophagy-specific complex of the Atg1 Ser/Thr kinase and regulatory subunits. It is required in the early biogenesis of the autophagosome. (Adapted from FBrf0219844 and PMID:23999079). | Q8MQJ7,Q9VHR6,Q7KTS2,Q9VWQ1 | 22562043 | Atg1/ULK1 kinase complex ; GO:1990316 | autophagy ; GO:0006914 | - | Y | ||||||||||||||
18 | FBgg0000281 | CPX-2746 | BRAHMA ASSOCIATED PROTEINS COMPLEX | Brahma SWI/SNF ATP-dependent chromatin remodeling complex | BAP | BAF complex|BRG1 associated factor | - | The Brahma associated proteins (BAP) complex is an ATP-dependent chromatin remodeling complex. (Adapted from FBrf0192510.) | P10987,(P02572),Q7K012,Q9VYG2,Q9W384,(Q9VLX2),P25439,Q7K3G5,Q9VF03,Q8IN94,Q24090,Q9W3G1,O76857 | 33232675,18299390,15060132 | brahma complex ; GO:0035060 | chromatin remodeling ; GO:0006338 | - | Y | Y | ||||||||||||
19 | FBgg0000094 | CPX-2747 | BBSOME | BBS | Bardet-Biedl Syndrome Proteins | BBSome | The BBSome is a complex of Bardet-Biedl Syndrome (BBS) proteins that are evolutionary related to coat protein complexes. It is involved in the trafficking of membrane proteins to primary cilia and interacts with IFT-A and IFT-B complexes in the intraflagella transport system. (Adapted from PMID:19575670 and FBrf0223369). | A1ZBK9,E1JIG6,Q9VS19,A1Z8E9,Q9I7P3,Q9VPP9,B7YZM8 | 15137945,23569277 | BBSome ; GO:0034464|cilium ; GO:0005929 | cilium assembly ; GO:0060271 | - | Y | ||||||||||||||
20 | FBgg0000185 | CPX-2753 | BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX-1 | BLOC-1 complex | BLOC1 | Biogenesis of lysosomal organelles complex-1 | BLOC-1 | The BLOC (biogenesis of lysosome-related organelles complex) complexes are required for the biogenesis of specialized organelles of the endosomal-lysosomal system. In mammalian cells, BLOC-1 localizes to early endosomes and facilitates protein trafficking to melanosomes in melanocytes. In D.mel, BLOC-1 has been shown to be involved in pigment granule biogenesis. (Adapted from FBrf0192474). | A1Z9S1,Q9VTE0,A8JNV4,Q9VTC2,Q9VVT5,Q0KI28,Q9VTM0,Q9VQF9 | 20102546,20015953,17156100,19083121 | BLOC-1 complex ; GO:0031083 | eye pigment granule organization ; GO:0008057 | - | Y | |||||||||||||
21 | FBgg0000110 | CPX-2755 | BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX-2 | BLOC-2 complex | BLOC2 | Biogenesis of lysosomal organelles complex-2 | BLOC-2 | The BLOC (biogenesis of lysosome-related organelles complex) complexes are required for the biogenesis of specialized organelles of the endosomal-lysosomal system. In mammalian cells, BLOC-2 localizes to early endosomes and facilitates protein trafficking to melanosomes in melanocytes. In D.mel, BLOC-2 has been shown to be involved in eye pigmentation. (Adapted from FBrf0192474). | Q9VNX0,Q9VHN9 | 20102546,17156100 | BLOC-2 complex ; GO:0031084 | compound eye pigmentation ; GO:0048072 | - | Y | |||||||||||||
22 | FBgg0000192 | CPX-2756 | BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX-3 | BLOC-3 complex | BLOC3 | Biogenesis of lysosomal organelles complex-3 | BLOC-3 | The BLOC (biogenesis of lysosome-related organelles complex) complexes are required for the biogenesis of specialized organelles of the endosomal-lysosomal system. BLOC-3 is proposed to regulate protein trafficking and organelle dynamics. (Adapted from FBrf0192474). | Q7K3N1,A1ZAX8 | 20102546,17156100 | BLOC-3 complex ; GO:0031085 | - | - | Y | |||||||||||||
23 | FBgg0001619 | CPX-2760 | BLOC1-RELATED COMPLEX | BORC complex | BORC | - | - | BLOC1-related complex (BORC) is a lysosome associated multi-subunit protein complex that promotes lysosome positioning through coupling to the small GTPase Arl8. This initiates a chain of interactions that promotes the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. (Adapted from PMID:25898167 and FBrf0241370). | A1Z9S1,Q9VTE0,Q9VYT1,Q9W0Q3,A1ZBV5,Q9VTY4,Q8IR45,Q9VQF9 | 30590083 | BORC complex ; GO:0099078 | lysosome localization ; GO:0032418 | - | Y | |||||||||||||
24 | FBgg0001765 | CPX-2761 | C/D SMALL NUCLEOLAR RIBONUCLEOPROTEIN COMPLEX | C-DRNP | - | C/D RNPs | The C/D small nucleolar ribonucleoprotein complex (C/D snoRNP) is a ribosome processing complex that catalyzes the site-specific 2'-O-methylation of ribosomal RNAs using box C/D snoRNAs as guides and assist the assembly of ribosomes. (Adapted from PMID:22065625 and FBrf0190937). | Q9W1V3,Q9VM69,Q95WY3,Q8MSW9 | 24394412,18776683,19285445 | box C/D RNP complex ; GO:0031428 | snoRNA guided rRNA 2'-O-methylation ; GO:0000452 | - | Y | ||||||||||||||
25 | FBgg0000295 | CPX-2763 | CHROMATIN ASSEMBLY FACTOR 1 | CAF-1 | - | CAF1 | Chromatin assembly factor 1 (CAF-1) is a highly conserved three-subunit histone chaperone in eukaryotes, which facilitates chromatin assembly by depositing histone H3 and H4 onto newly synthesized DNA. CAF-1 is also implicated in epigenetic regulation. (Adapted from FBrf0222414). | Q24572,A1Z898,Q9W3D1 | 11533245,23942516 | CAF-1 complex ; GO:0033186 | nucleosome assembly ; GO:0006334 | - | Y | ||||||||||||||
26 | FBgg0000356 | CPX-2764 | CDK-ACTIVATING KINASE COMPLEX | CAK | cyclin-dependent protein kinase-activating kinase | - | The cyclin-dependent kinase (CDK)-activating kinase (CAK) complex is a three-subunit kinase module present as a subcomplex of TFIIH, as free trimeric CAK or in complex with the ATP-dependent DNA helicase XPD (Xpd in D.mel). The TFIIH-associated CAK complex phosphorylates the C-terminal domain of RNA pol II. The free form of CAK activates the cell cycle CDKs. The CAK-XPD complex regulates the cell cycle progression in mitosis. (Adapted from FBrf0227236 and PMID:21592869). | Q24216,O76513,Q7KPG8 | 19008953,10908585,15354295,11447116,25431422 | carboxy-terminal domain protein kinase complex ; GO:0032806|transcription factor TFIIH holo complex ; GO:0005675 | regulation of cyclin-dependent protein serine/threonine kinase activity ; GO:0000079|transcription initiation from RNA polymerase II promoter ; GO:0006367 | cyclin-dependent protein serine/threonine kinase activity ; GO:0004693|RNA polymerase II CTD heptapeptide repeat kinase activity ; GO:0008353 | Y | ||||||||||||||
27 | FBgg0000354 | CDK-ACTIVATING KINASE-XERODERMA PIGMENTOSUM D COMPLEX | CAK-XPD | - | - | The cyclin-dependent kinase (CDK)-activating kinase-Xeroderma pigmentosum D (CAK-XPD) complex is a four-subunit kinase module. CAK-XPD has a role in the regulation of the cell cycle progression in mitosis, where XPD negatively regulates the cell cycle function of the CAK activity. (Adapted from FBrf0227236, FBrf0211947, FBrf0159708 and PMID:21592869). | Q24216,O76513,Q7KPG8,Q7KVP9 | 12853965,11447116,20300654,25431422 | nucleus ; GO:0005634 | regulation of cyclin-dependent protein serine/threonine kinase activity ; GO:0000079 | - | ||||||||||||||||
28 | FBgg0000773 | CPX-2767 | CBF DOMAIN TRANSCRIPTION FACTORS | CCAAT-binding factor complex | CBFTF | NF-Y complex|nuclear factor Y-box complex | - | The CCAAT motif-binding factor (CBF) transcription factor is a sequence specific DNA-binding protein complex that regulates transcription. The CBF factor consists of three different subunits, that interact with each other to form the nuclear factor Y-box (NF-Y) complex that recognizes the CCAAT-box DNA motifs. (Adapted from FBrf0220141). | Q9VSY9,Q8ST61,Q9W3V9 | 24359758,23470843,17216611 | CCAAT-binding factor complex ; GO:0016602 | regulation of transcription, DNA-templated ; GO:0006355 | DNA-binding transcription factor activity ; GO:0003700|transcription cis-regulatory region binding ; GO:0000976 | Y | |||||||||||||
29 | FBgg0000621 | CPX-2768 | CORE CLEAVAGE COMPLEX | Histone pre-RNA core cleavage complex | CCC | - | - | The core cleavage complex is a component of two distinct complexes, the cleavage/polyadenylation complex and the histone pre-mRNA cleavage complex that processes nonpolyadenylated histone pre-mRNAs. (Adapted from FBrf0229062 and FBrf0208078). | Q9VE51,Q9V3D6,Q8MSU4, Q9VE52 | 28415970,26081560,24145821,19450530 | mRNA cleavage factor complex ; GO:0005849 | mRNA 3'-end processing by stem-loop binding and cleavage ; GO:0006398 | mRNA binding ; GO:0003729 | FBgn0027841, CstF64 in CPX group; is FBgg0000615 (line 87) actually the equivalent to CPX group? Check this | |||||||||||||
30 | FBgg0000469 | CPX-2771 | CCR4-NOT COMPLEX | CCR4-NOT mRNA deadenylase complex | CCR4-NOT | - | - | The CCR4-NOT complex is a conserved multi-subunit complex implicated in various cellular processes to regulated gene expression. It is best characterised in its role as the main enzyme responsible for the deadenylation of mRNA. The conserved core of the complex is composed of two modules: the NOT module and a catalytic module comprising two deadenylases, twin and Pop2. (Adapted from FBrf0221179 and FBrf0231273). | A0A0B4LEZ3,Q7K126,Q9V3G6,Q8MLP8,X2JCC3,Q7JVP2,Q94547,Q8IMX1 | 23303381,15215893,20504953,24904643 | CCR4-NOT complex ; GO:0030014 | mRNA catabolic process ; GO:0006402|negative regulation of translation ; GO:0017148 | poly(A)-specific ribonuclease activity ; GO:0004535 | Y | |||||||||||||
31 | FBgg0000505 | CPX-2772 | CHAPERONIN CONTAINING TCP-1 COMPLEX | Chaperonin-containing T-complex | CCT | HEAT SHOCK PROTEIN 60 CHAPERONINS - GROUP II|Chaperonin Containing TCP-1 complex|TCP-1 Ring Complex | HSP60-II|TRiC | Group II Heat Shock Protein 60 chaperonins are paralogous subunits that assemble to form a multi-subunit ring complex, the TCP-1 Ring Complex (TRiC) or Chaperonin Containing TCP-1 (CCT) complex. Within the cytoplasm, TRiC/CCT catalyses the ATP-dependent folding of approximately 10% of of newly synthesized proteins. (Adapted from FBrf0210519, FBrf0232269 and PMID:11580267). | P12613,Q9W392,P48605,Q9VK69,Q7KKI0,Q9VXQ5,Q9VHL2,Q7K3J0 | 20122915 | chaperonin-containing T-complex ; GO:0005832 | protein folding ; GO:0006457 | ATP-dependent protein folding chaperone ; GO:0140662 | Y | |||||||||||||
32 | FBgg0000609 | CPX-2789 | CEP290 COMPLEX | CEP290C | CEP290 Module | - | The CEP290 complex or module is protein complex located at the ciliary transition zone. It is involved in the assembly of transition zone components. (Adapted from FBrf0233737 and FBrf0233580). | Q9W0M1,B7YZJ4 | 27646273 | ciliary transition zone ; GO:0035869 | cilium assembly ; GO:0060271 | - | Y | ||||||||||||||
33 | FBgg0001749 | CPX-2774 | CHAT COMPLEX | CHAT histone acetyltransferase complex | CHAT | Chiffon histone acetyltransferase (CHAT) complex | - | The chiffon histone acetyltransferase (CHAT) complex is a unique Gcn5 complex specific to insects that shows characteristic histone acetyltransferase activity towards histone H3. (Adapted from FBrf0241207, FBrf0247978 and FBrf0248705). | Q8I8V0-2,M9PHZ1,Q9NK54,Q9VTZ1,Q9W2I4 | 32739556,32735945,30559249 | - | histone acetylation ; GO:0016573 | histone acetyltransferase activity ; GO:0004402 | Y | Y | ||||||||||||
34 | FBgg0000299 | CPX-2775 | CHROMATIN ACCESSIBILITY COMPLEX | CHRAC chromatin remodeling complex | CHRAC | CHROMATIN ACCESSIBILITY COMPLEX (CHRAC)|Chromatin accessibility complex | - | CHRAC is an ISWI-containing chromatin remodeling complex that optimizes nucleosome spacing to promote chromatin assembly and the repression of transcription. (Adapted from FBrf0228920). | Q9V9T4,Q9V444,Q9V452,Q24368 | 16821138,19355820,11447119 | CHRAC ; GO:0008623 | nucleosome mobilization ; GO:0042766 | ATP-dependent chromatin remodeler activity ; GO:0140658 | Y | |||||||||||||
35 | FBgg0000123 | CPX-2792 | CLATHRIN COMPLEX | CLATH | Clathrin triskelion | - | Clathrin is the major component of coated vesicles. It is a heterohexamer formed from three clathrin light chains and three heavy chains adopting a three-legged triskelion structure. To form coated vesicles, clathrin assembles into a polygonal lattice around the invaginating membrane, interacting with adaptors proteins which in-turn interact with the membrane. After membrane scission, the clatherin cage is disassembled from the vesicle. (Adapted from PMID:17702618). | P29742,Q9VWA1 | 18364232 | clathrin complex ; GO:0071439|clathrin vesicle coat ; GO:0030125 | vesicle-mediated transport ; GO:0016192 | clathrin binding ; GO:0030276 | Y | ||||||||||||||
36 | FBgg0001612 | CPX-2671 | CMG COMPLEX | CMG | Cdc45-MCM-GINS complex|unwindosome | - | The CMG (Cdc45-MCM-GINS) complex is the eukaryotic replicative helicase, the enzyme that unwinds double-stranded DNA at replication forks. It is a macromolecular assembly of three replication factors: the Cdc45 protein, and the MCM and GINS complexes. All three components are essential for CMG function, with the MCM2-7 complex functioning as the molecular motor that harnesses the energy of ATP hydrolysis to catalyse strand separation. (Adapted from PMID:23412083.) | O96989,Q26454,P49735,Q9XYU1,Q9VGW6,Q9V461,Q9XYU0,Q9W0I7,Q9VQY9,Q9W2V7,Q9VBI1 | 21378962,25117490,20122406,16798881 | CMG complex ; GO:0071162 | DNA unwinding involved in DNA replication ; GO:0006268|pre-replicative complex assembly involved in nuclear cell cycle DNA replication ; GO:0006267 | double-stranded DNA helicase activity ; GO:0036121 | Y | ||||||||||||||
37 | FBgg0001066 | CPX-2337 | CSL-NOTCH-MASTERMIND TRANSCRIPTION FACTOR COMPLEX | CNM | CSL-NICD-MAM ternary complex | CSL-NICD-MAM | The CSL-Notch-Mastermind transcription factor complex consisting of the CSL protein, Su(H), and mastermind (mam) protein, in complex with Notch intracellular domain (generated by ligand-stimulated N-cleavage), up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0232880). | P21519,P07207,P28159 | 25650119,21737682,27404588 | CSL-Notch-Mastermind transcription factor complex ; GO:1990433 | Notch signaling pathway ; GO:0007219|positive regulation of transcription by RNA polymerase II ; GO:0045944 | DNA-binding transcription factor activity, RNA polymerase II-specific ; GO:0000981 | Y | ||||||||||||||
38 | FBgg0000467 | CPX-2794 | CONSERVED OLIGOMERIC GOLGI COMPLEX | COG | - | COC|GOC | The conserved oligomeric Golgi (COG) complex is a multi-subunit tethering complex of the CATCHR family that functions as a vesicular tether during retrograde intra-Golgi trafficking. (Adapted from PMID:23839779). | Q9VGC3,Q9VF78,Q961G1,Q95TN4,Q9V564,Q9VAD6,Q9VKH0,Q9VJD3 | 22946051,25453831,18353293 | Golgi transport complex ; GO:0017119 | Golgi organization ; GO:0007030|intra-Golgi vesicle-mediated transport ; GO:0006891 | - | Y | ||||||||||||||
39 | FBgg0000156 | CPX-2796 | MITOTIC COHESIN COMPLEX | Nuclear mitotic cohesin complex | COHSN | - | - | The cohesin complex forms a ring-like structure which encircles sister chromatids holding them together after DNA replication. Cohesin also has roles in the regulation of gene expression and DNA repair. (Adapted from FBrf0207490). | Q9VM62,Q9VCD8,Q9VXE9,O96689 | 19308700 | cohesin complex ; GO:0008278 | sister chromatid cohesion ; GO:0007062 | chromatin binding ; GO:0003682 | Y | |||||||||||||
40 | FBgg0001799 | CPX-2779 | MEIOTIC COHESIN COMPLEX SOLO-SUNN VARIANT | Nuclear meiotic cohesin complex, SOLO-SUNN variant | COHSN-SOLO-SUNN | Q9VTM9, Q9VCD8,Q9VXE9,B6JUP5 | 30479058, 27291057 | N | Y | ||||||||||||||||||
41 | FBgg0001800 | CPX-2780 | MEIOTIC COHESIN COMPLEX C2M-SA VARIANT | Nuclear meiotic cohesin complex, C2M-SA variant | COHSN-C2M-SA | Q9VM62,Q9VCD8,Q9VXE9, Q9VJL5 | 27291057 | N | Y | ||||||||||||||||||
42 | FBgg0000296 | CPX-2798 | COMPASS COMPLEX | COMP | Complex proteins associated with Set1 complex|SET1C complex|Set1/COMPASS | dSet1|Set1 | COMPASS is a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation in Drosophila. (Adapted from FBrf0216343). | Q94545,Q9W352,Q9VKQ9,Q9V4C8,Q9VPH8,Q5LJZ2,Q9VLN1,Q9V3J8 | 21875999,27257261,22108599,22663077 | Set1C/COMPASS complex ; GO:0048188 | histone H3-K4 methylation ; GO:0051568 | histone methyltransferase activity (H3-K4 specific) ; GO:0042800 | Y | ||||||||||||||
43 | FBgg0000173 | CPX-2813 | CONDENSIN I | COND-I | Canonical condensin complex | - | Condensin I is conserved from yeast to humans. Condensin I is involved in the condensation and segregation of chromosomes. Condensin complexes consist of five subunits: a Structural Maintenance of Chromosomes (SMC) 2/4 heterodimer and three regulatory, non-SMC subunits. (Adapted from FBrf0191647). | Q9VIP9,Q9VAJ1,A1Z987,Q9V3A7,Q7KK96 | 21923481,22855829,14532007 | condensin complex ; GO:0000796 | chromosome condensation ; GO:0030261|chromosome separation ; GO:0051304 | chromatin binding ; GO:0003682 | Y | ||||||||||||||
44 | FBgg0000108 | CPX-2814 | CONDENSIN II | COND-II | - | - | In D.mel, the existence of a condensin II complex is disputed as no CAP-G2 subunit or equivalent has been identified. However, the condensin II subunit orthologs have been implicated in various aspects of chromosome organisation. (Adapted from FBrf0191647 and FBrf0225011). | Q9VMQ4,Q8INL2,Q9V3A7,Q7KK96 | 22855829,14532007 | condensin complex ; GO:0000796 | chromosome condensation ; GO:0030261|chromosome separation ; GO:0051304 | chromatin binding ; GO:0003682 | Y | ||||||||||||||
45 | FBgg0000087 | CPX-2820 | COAT PROTEIN COMPLEX I | COPI vesicle coat complex | COPI | Coatomer | - | The Coat Protein Complex I (COPI or coatomer) is responsible for retrograde transport from the Golgi to ER. It is composed of seven subunits: the alpha, beta, delta and gamma subunits form the cargo adaptor and the beta', epsilon and zeta form the vesicle cage. The small Ras GTPase, Arf1 (Arf79F in D.mel) recruits the complex to Golgi membranes in its GTP-bound form. (Adapted from PMID:22160157). | P61209,Q9W0B8,O62621,P45437,Q8I0G5,Q9W555,Q9Y0Y5,Q9VV89 | 19067489,22553212 | COPI vesicle coat ; GO:0030126 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; GO:0006890 | - | Y | |||||||||||||
46 | FBgg0000116 | CPX-2400 | COAT PROTEIN COMPLEX II | COPII vesicle coat complex | COPII | - | - | The Coat Protein Complex II (COPII) mediates protein transport from the ER to Golgi (anterograde transport). COPII recruitment is initiated by the activation of the small GTPase Sar1. Sar1 recruits a heterodimeric complex comprising of Sec23/24, which interacts with cargo and the outer cage - a heterotetramer composed of Sec13/31. (Adapted from PMID:18060556). | Q9VD29,Q9V3J4,A0A0B4K5Z8,A1Z813,M9PC99,A0A0B4LEZ1 | 23902691 | COPII vesicle coat ; GO:0030127 | endoplasmic reticulum to Golgi vesicle-mediated transport ; GO:0006888 | - | Y | |||||||||||||
47 | FBgg0000592 | CPX-2402 | CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL SUBUNITS | CRAC | SOCE channels|Store-operated calcium entry channels | CRAC-C | Ca[2+] release-activated Ca[2+] (CRAC) channels function in store-operated Ca[2+] entry, a mechanism for Ca[2+] entry across the plasma membrane modulated by intracellular (mainly endoplasmic reticulum) Ca[2+] stores. CRAC channels are highly Ca[2+] selective and are composed of ORAI pore-forming subunits (olf186-F in D.mel) and the stromal interaction molecule (Stim), a Ca[2+] sensor. (Adapted from FBrf0214207 and PMID:27130253). | Q9U6B8,P83094 | 22100727,17293345,20807283,24213636,16751269 | - | store-operated calcium entry ; GO:0002115 | store-operated calcium channel activity ; GO:0015279 | Y | ||||||||||||||
48 | FBgg0001763 | CPX-2408 | CRUMBS COMPLEX | CRUMBS-PALS1-PATJ cell polarity complex | CRBC | CRB complex | - | The crumbs protein complex is one of the key regulators of apical cell polarity and cell shape, more specifically epithelial and photoreceptor cells. The core components of the crumbs complex are scaffolding proteins and recruit other polarity module proteins into close proximity. (Adapted from FBrf0239410 and FBrf0204878). | P10040,Q9NB04,E2QD98, (Q8IMT8) | 18177979,23136386,29651238 | - | establishment or maintenance of cell polarity ; GO:0007163 | - | Removed veli | N | Y | |||||||||||
49 | FBgg0001809 | CPX-2417 | BETA CATENIN DESTRUCTION COMPLEX APC2 VARIANT | Beta-catenin destruction complex, Apc2 variant | DES-C2 | Destruction complex; beta-catenin destruction complex | - | The beta-catenin destruction complex is a cytoplasmic protein complex that phosphorylates beta-catenin, targeting it for ubiquitin-mediated proteolysis. In the absence of Wnt signaling, the beta-catenin destruction complex constitutively suppresses the canonical Wnt signaling pathway by preventing the accumulation of cytoplasmic beta-catenin (arm). (Adapted from FBrf0217546). | Q9Y1T2,(Q9VAS9),Q9V407,P54367,P18431 | 22174073,24931405 | beta-catenin destruction complex ; GO:0030877 | negative regulation of canonical Wnt signaling pathway ; GO:0090090 | - | make separate flavours of beta cat for FB | N | Y | |||||||||||
50 | FBgg0000896 | CPX-2418 | BETA CATENIN DESTRUCTION COMPLEX APC VARIANT | Beta-catenin destruction complex, Apc variant | DES-C | Destruction complex; beta-catenin destruction complex | Q9VAS9,Q9V407,P54367,P18431 | 22174073,24931405 | beta-catenin destruction complex ; GO:0030877 | negative regulation of canonical Wnt signaling pathway ; GO:0090090 | - | make separate flavours of beta cat for FB | N | Y | |||||||||||||
51 | FBgg0000473 | CPX-2420 | DYSTROPHIN GLYCOPROTEIN COMPLEX | DGC | Dystrophin-associated protein complex|Dystrophin complex | DAPC|DC|DPC | The Dystrophin glycoprotein complex (DGC) is a plasma membrane transmembrane complex that links the actin cytoskeleton to the extracellular matrix. The DGC is important for maintaining the integrity of skeletal and cardiac muscle cells. It also functions as a scaffold for proteins involved in signaling and accumulates at the neuromuscular junction and at a variety of synapses in the peripheral and central nervous system. (Adapted from FBrf0212855 and FBrf0129834). | A0A0C4DHF6,A8DYB7,Q9VDW6,M9PF78,Q9VG77,O76892,Q9VNY2,A1ZAH3 | 15161095,11018515,19899002 | dystrophin-associated glycoprotein complex ; GO:0016010 | - | structural constituent of muscle ; GO:0008307 | Y | ||||||||||||||
52 | FBgg0001209 | CPX-2090 | DNA POLYMERASE ALPHA-PRIMASE | DNAPOLA | - | DNApolalpha|Polalpha | DNA polymerase alpha-primase synthesizes short RNA-DNA primers on the lagging strand during DNA synthesis. It is a heterotetramer composed of two polymerase subunits (DNApol-alpha180 and DNApol-alpha73) and two primase subunits (DNApol-alpha50 and DNApol-alpha60). DNApol-alpha180 and DNApol-alpha50 encode the DNA polymerase and RNA primase catalytic activities, respectively, while DNApol-alpha73 and DNApol-alpha60 encode the regulatory subunits. (Adapted from PMID:30005324.) | P26019,Q9VB62,Q24317,Q9VPH2 | 31933406 | alpha DNA polymerase:primase complex ; GO:0005658|nucleus ; GO:0005634 | lagging strand elongation ; GO:0006273 | DNA-directed DNA polymerase activity ; GO:0003887|DNA primase activity ; GO:0003896 | Y | ||||||||||||||
53 | FBgg0001211 | CPX-2421 | DNA POLYMERASE DELTA | DNAPOLD | - | - | DNA polymerase delta functions as a leading strand polymerase during nuclear DNA synthesis. It is a multi-subunit enzyme in which DNApol-delta encodes the catalytic subunit with polymerase and 3'-5' exonuclease proofreading activities. (Adapted from PMID:30005324.) | P54358,Q9W088,Q9Y118 | 31933406 | delta DNA polymerase complex ; GO:0043625|nucleus ; GO:0005634 | DNA replication proofreading ; GO:0045004|leading strand elongation ; GO:0006272 | 3'-5'-exodeoxyribonuclease activity ; GO:0008296|DNA-directed DNA polymerase activity ; GO:0003887 | Y | ||||||||||||||
54 | FBgg0001210 | CPX-2422 | DNA POLYMERASE EPSILON | DNAPOLE | - | - | DNA polymerase epsilon functions as a leading strand polymerase during nuclear DNA synthesis. It is a heterotetramer in which DNApol-epsilon255 encodes the catalytic subunit with polymerase and 3'-5' exonuclease proofreading activities. (Adapted from PMID:30005324.) | Q9V444,Q9VCN1,Q9VRQ7,Q9W256 | 31933406 | epsilon DNA polymerase complex ; GO:0008622|nucleus ; GO:0005634 | DNA replication proofreading ; GO:0045004|leading strand elongation ; GO:0006272 | 3'-5'-exodeoxyribonuclease activity ; GO:0008296|DNA-directed DNA polymerase activity ; GO:0003887 | Y | ||||||||||||||
55 | FBgg0001216 | CPX-2096 | DNA POLYMERASE GAMMA | DNAPOLG | - | - | DNA polymerase gamma is a high-fidelity mitochondrial polymerase responsible for the replication and repair of mitochondrial DNA. It is a heterodimer in which the catalytic subunit is encoded by tam. (Adapted from PMID:30005324.) | Q27607,Q9VJV8 | 31933406 | gamma DNA polymerase complex ; GO:0005760|mitochondrion ; GO:0005739 | mitochondrial DNA repair ; GO:0043504|mitochondrial DNA replication ; GO:0006264 | DNA-directed DNA polymerase activity ; GO:0003887 | Y | ||||||||||||||
56 | FBgg0001212 | CPX-2426 | DNA POLYMERASE ZETA | DNAPOLZ | - | - | DNA polymerase zeta is one of several translesion synthesis polymerases that act to promote replication through DNA lesions that would otherwise stall the replicative polymerases. It is a heterotetramer, in which the catalytic subunit is encoded by DNApol-zeta, and is specialized for the extension step of lesion bypass. (Adapted from PMID:30005324.) | Q9W088,Q9Y118,Q9GSR1,Q9VNE1 | 31933406 | nucleus ; GO:0005634|zeta DNA polymerase complex ; GO:0016035 | translesion synthesis ; GO:0019985 | DNA-directed DNA polymerase activity ; GO:0003887 | Y | ||||||||||||||
57 | FBgg0000298 | CPX-2427 | dRING-ASSOCIATED FACTORS | DRAF | - | dRAF | The Drosophila Polycomb group complex dRING-associated factors (dRAF) catalyzes histone H2A K119 ubiquitination and H3K36me2 removal. Therefore, dRAF removes an active mark from histone H3 and adds a repressive one to H2A. (Adapted from FBrf0215737). | Q9VHH9,P35820,Q9VB08 | 28778878,18923078,22994356 | PcG protein complex ; GO:0031519 | histone H2A ubiquitination ; GO:0033522|histone H3-K36 demethylation ; GO:0070544 | ubiquitin-protein transferase activity ; GO:0004842 | Y | ||||||||||||||
58 | FBgg0001728 | CPX-2429 | DRB SENSITIVITY-INDUCING FACTOR COMPLEX | DSIF | - | Spt4/5 | The DRB sensitivity-inducing factor (DSIF) complex is a heterodimer that acts as both a positive and negative transcription elongation factor. DSIF together with negative elongation factor (NELF) complex associates with RNA polymerase II and causes transcriptional pausing. Phosphorylation of DSIF-NELF complexes dissociates NELF from the elongation complex and transforms DSIF into a positive elongation factor. (Adapted from FBrf0235113, FBrf0211126 and FBrf0203142). | Q9TVQ5,Q9V460 | 20534440,28213523,15741180 | DSIF complex ; GO:0032044 | regulation of transcription elongation from RNA polymerase II promoter ; GO:0034243 | RNA polymerase II complex binding ; GO:0000993 | Y | ||||||||||||||
59 | FBgg0000376 | CPX-2434 | DYNACTIN COMPLEX | DYNA-C | Dynein activator complex | DCTN | Dynactin is a large 1.2 MDa multisubunit protein complex that associates with the cytoplasmic dynein complex to drive microtubule-based transport. (Adapted from PMID:15473859 and PMID:25751425). | P45889,Q9VWE8,Q7JQV2,Q9W2N0,P48603,P13496,Q7K2D2,Q9W1V8,Q7K130,Q9VJQ6,Q9VIZ1 | 25794683,12857853,22726940 | dynactin complex ; GO:0005869 | microtubule-based movement ; GO:0007018 | - | Y | ||||||||||||||
60 | FBgg0000720 | CPX-2439 | ELBA BOUNDARY FACTOR COMPLEX | ELBA | Early boundary activity|Elba factor | - | The heterotrimeric insulator complex ELBA is a chromatin boundary factor, which binds to specific DNA and confers insulator activity during early embryogenesis. (Adapted from FBrf0227658 and FBrf0221291). | Q9VR17,Q9VQD6,Q9VR19 | 23240086,24135698,25561495 | chromatin silencing complex ; GO:0005677 | negative regulation of transcription, DNA-templated ; GO:0045892 | chromatin insulator sequence binding ; GO:0043035 | Y | ||||||||||||||
61 | FBgg0000599 | CPX-2441 | ELG1 COMPLEX | Elg1-RFC-like complex | ELG1-C | Elg1 PCNA-unloader complex|Elg1 replication factor C-like complex | Elg1-RLC | The Elg1 complex (Elg1-C) is a pentameric replication factor C (RFC)-like complex. Elg1-C unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin. (Adapted from FBrf0232456). | Q9VX15,Q86BP6,Q9VKW3,P53034,Q9U9Q1 | 27198229 | Elg1 RFC-like complex ; GO:0031391 | - | - | Y | |||||||||||||
62 | FBgg0001733 | CPX-2444 | ELONGIN COMPLEX | Elongin transcription elongation complex | ELO | - | - | Elongin complex is a transcription elongation factor that increases RNA polymerase II elongation rate by suppressing transient pausing. Elongin complex is a heterotrimer composed of the large transcriptionally active subunit elongin A and two regulatory subunits elongin B and C, which form a stable subcomplex that binds to subunit A. (Adapted from FBrf0223250 and FBrf0180540). | Q9VCP0,O44226,Q7JWD6 | 19279664,24204884 | elongin complex ; GO:0070449 | positive regulation of transcription elongation from RNA polymerase II promoter ; GO:0032968 | - | Y | |||||||||||||
63 | FBgg0001289 | CPX-2445 | ER MEMBRANE PROTEIN COMPLEX EMC2A VARIANT | Endoplasmic reticulum membrane complex, EMC2A variant | EMC | ER membrane protein complex | - | The ER membrane protein complex (EMC) is a widely conserved and abundant complex found in the endoplasmic reticulum of eukaryotic cells. The mammalian EMC comprises ~10 subunits, in which EMC8 and EMC9 are ~40% identical and appear to be the result of a recent gene duplication. In D. melanogaster, there is a single gene encoding EMC8/9, whereas the EMC2 gene is duplicated (resulting in EMC2A and EMC2B). EMC can directly mediate the insertion of transmembrane domains (TMDs) into the lipid bilayer and may participate in the folding/assembly of other types of membrane proteins transiting through the ER by serving as a chaperone. EMC disruption has pleiotropic phenotypes, often impacting the abundance or localization of membrane proteins and affecting protein trafficking, organelle communication, ER stress, viral maturation and lipid homeostasis. (Adapted from PMID:30826214.) | Q9VHY6,Q9VEQ1,Q9VKR0,Q9VNQ3,Q9VJ25,Q9VBZ8,A1ZA83,Q9W1Y1,Q8IPT0 | 31263175 | EMC complex ; GO:0072546 | - | - | make separate flavours of EMC for FB | N | Y | |||||||||||
64 | New Group: FBgg0001812 | CPX-2451 | ER MEMBRANE PROTEIN COMPLEX EMC2B VARIANT | Endoplasmic reticulum membrane complex, EMC2B variant | EMC2B | Q9VHY6,Q9VEQ2,Q9VKR0,Q9VNQ3,Q9VJ25,Q9VBZ8,A1ZA83,Q9W1Y1,Q8IPT0 | make separate flavours of EMC for FB | N | Y | ||||||||||||||||||
65 | FBgg0000604 | CPX-2442 | ENOK COMPLEX | Enok histone acetyltransferase complex | ENOK-C | - | - | The Enok complex (Enok-C) is an histone lysine acetyltransferase 6 (KAT6) complex. The Enok-C preferentially acetylates histone H3 residues. KAT6 complexes are highly conserved in eukaryotes and are involved in cell cycle regulation. (Adapted from FBrf0232456). | Q7JVP4,Q9VRN3,Q9W1A9,Q9VJY8 | 27198229 | MOZ/MORF histone acetyltransferase complex ; GO:0070776 | histone H3 acetylation ; GO:0043966|regulation of cell cycle ; GO:0051726 | histone acetyltransferase activity (H3-K23 specific) ; GO:0043994 | Y | |||||||||||||
66 | FBgg0000052 | CPX-2452 | ESCRT-0 COMPLEX | ESCRT-0 | Endosomal Sorting Complex Required for Transport 0|Hrs-STAM complex | ESCRT 0 | The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-0 initiates mediates multivesicular body (MVB) formation, binding ubiquitinated membrane proteins destined for degradation and concentrating them in early endosome membranes. ESCRT-0 recruits ESCRT-I. (Adapted from PMID:22361144 and FBrf0209668). | Q960X8,Q9XTL2 | 25486452,20059450 | ESCRT-0 complex ; GO:0033565 | endosome transport via multivesicular body sorting pathway ; GO:0032509 | ubiquitin binding ; GO:0043130 | Y | ||||||||||||||
67 | New ID: FBgg0001813 | CPX-2457 | ESCRT-I COMPLEX ESCRT-I COMPLEX VPS37B VARIANT | ESCRT-I complex, Vps37B variant | ESCRT-I ESCRT-IB | Endosomal Sorting Complex Required for Transport I | ESCRT I | The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-I is constitutive heterotetrameric complex. It interacts with ESCRT-O, -II and ubiquitin. Together with ESCRT-II, it mediates the formation of the membrane bud and stabilizes the neck region. (Adapted from PMID:22361144 and FBrf0209668). | Q9VWY7,Q9VVA7,Q9VN88,O77259 | 25486452,20059450,19571114 | ESCRT I complex ; GO:0000813 | endosome transport via multivesicular body sorting pathway ; GO:0032509 | - | make separate flavours of ESCRT-1 for FB | N | Y | |||||||||||
68 | New Group: FBgg0001814 | CPX-2460 | ESCRT-I COMPLEX VPS37A VARIANT | ESCRT-I complex, Vps37A variant | ESCRT-IA | The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-I is constitutive heterotetrameric complex. It interacts with ESCRT-O, -II and ubiquitin. Together with ESCRT-II, it mediates the formation of the membrane bud and stabilizes the neck region. (Adapted from PMID:22361144 and FBrf0209668). | Q9VWY7,Q9VVA7,Q9V359,O77259 | 25486452,20059450,19571114 | ESCRT I complex ; GO:0000813 | endosome transport via multivesicular body sorting pathway ; GO:0032509 | - | make separate flavours of ESCRT-1 for FB | N | Y | |||||||||||||
69 | FBgg0000207 | CPX-2458 | ESCRT-II COMPLEX | ESCRT-II | Endosomal Sorting Complex Required for Transport II | ESCRT II | The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-II is a constitutive heterotetramer. It interacts with 3-phosphoinositides, ubiquitin and ESCRT-I, with which it mediates the formation of the membrane bud and stabilizes the neck region. It recruits ESCRT-III. (Adapted from PMID:22361144 and FBrf0209668). | Q9VD72,Q7JXV9,Q9VU87 | 25486452,20059450,19571114 | ESCRT II complex ; GO:0000814 | endosome transport via multivesicular body sorting pathway ; GO:0032509 | - | Y | ||||||||||||||
70 | FBgg0000057 | CPX-2459 | ESCRT-III COMPLEX | ESCRT-III | Charged Multivesicular Body Proteins|Endosomal Sorting Complex Required for Transport III | CHMPs|ESCRT III | The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-III is a dynamic complex, that assembles on endosomes. The components of the complex are less well defined, but it has four core subunits. It assembles into a filament around the neck of the budding vesicle. ESCRT-III mediates the recruitment of deubiquitinases and, together with the Vps4-Vta1 complex, which it recruits, mediates membrane scission. (Adapted from PMID:22361144 and FBrf0209668). | Q9Y124,Q95SH2,Q9VRJ5,Q8T0Q4,Q9VBI3,Q9W236,Q9VN02,Q9VVI9 | 22724069,25486452,20059450,19571114 | ESCRT III complex ; GO:0000815 | endosome transport via multivesicular body sorting pathway ; GO:0032509 | - | Y | ||||||||||||||
71 | FBgg0000107 | CPX-2465 | EXOCYST | EXOC | Exocyst complex|Sec6/8 complex | Exo | The exocyst complex is composed of eight proteins. It is involved tethering secretory vesicles to the plasma membrane and may regulate other aspects of intracellular trafficking such as SNARE assembly, cytokinesis and endocytic recycling. The exocyst complex is a member of the Complex Associated with Tethering Containing Helical Rods (CATCHR) family. (Adapted from FBrf0219543). | Q9VSJ8,Q7KRZ3,Q9VVG4,Q9VQQ9,Q9V8K2,Q9VNH6,Q9XTM1,Q9VDE6 | 25453831,22420621 | exocyst ; GO:0000145 | vesicle-mediated transport ; GO:0016192 | - | Y | ||||||||||||||
72 | FBgg0000282 | CPX-2466 | FACT COMPLEX | FACT | Facilitates chromatin transcription complex | - | FACT (facilitates chromatin transcription) is a heterodimer that destabilizes interactions between the H2A/H2B dimer and the H3/H4 tetramer of nucleosomes. FACT is involved in multiple processes such as transcription elongation, DNA replication and repair. (Adapted from FBrf0208591). | Q8IRG6,Q05344 | 14698615,12815073,19605348 | FACT complex ; GO:0035101 | regulation of chromatin assembly or disassembly ; GO:0001672 | nucleosome binding ; GO:0031491 | Y | ||||||||||||||
73 | FBgg0001771 | CPX-2801 | GAMMA-TUBULIN RING COMPLEX | G-TURC | Gamma-Tubulin large complex | gamma-TuRC | Gamma-tubulin ring complex (gamma-TuRC) is a multiprotein complex composed of the core subunit G-TUSC (gamma-TuSC) and additional Grip-motif proteins to form the ring-shaped complex. G-TURC localizes to the centrosome and catalyze the microtubule nucleation. (Adapted from FBrf0190946). | Q9VJ57,Q9VKU7,Q9XYP7,Q9XYP8,Q9VXU8,Q9VTS3,P23257,P42271 | 12631720,10037793 | gamma-tubulin large complex ; GO:0000931 | microtubule nucleation ; GO:0007020 | - | Y | ||||||||||||||
74 | FBgg0001768 | CPX-2776 | GAMMA-TUBULIN SMALL COMPLEX | G-TUSC | - | gamma-TuSC | Gamma-tubulin small complex (gamma-TuSC) is the core subunit of the G-TURC (gamma-TuRC), is a heterotetramer composed of two molecules of gamma-tubulin associated with two Grip-motif proteins. (Adapted from FBrf0191157). | Q9XYP7,Q9XYP8,P23257,P42271 | 12631720,10037793 | gamma-tubulin small complex ; GO:0008275 | microtubule nucleation ; GO:0007020 | - | Y | ||||||||||||||
75 | FBgg0000471 | CPX-2793 | GOLGI-ASSOCIATED RETROGRADE PROTEIN COMPLEX I | GARPI | - | - | GARP is a tethering complex, which is found on the Golgi and involved in retrograde traffic from endosomes. GARP complex has been shown to exist in two versions, called GARPI and GARPII, that differ in their composition. (Adapted from FBrf0226902). | Q9VLC0,Q8MSY4,Q9VMQ8,Q9VQY8 | 25453831,25486452,25795912 | GARP complex ; GO:0000938 | endocytic recycling ; GO:0032456 | - | Y | ||||||||||||||
76 | FBgg0000472 | CPX-2788 | GOLGI-ASSOCIATED RETROGRADE PROTEIN COMPLEX II | GARPII | Endosome-associated recycling protein | EARP | GARP is a tethering complex, which is found on the Golgi and involved in retrograde traffic from endosomes. GARP complex has been shown to exist in two versions, called GARPI and GARPII, that differ in their composition. GARPII can interact with Rab4. (Adapted from FBrf0226902). | A1ZAY8,Q8MSY4,Q9VMQ8,Q9VQY8 | 25453831 | GARP complex ; GO:0000938 | endocytic recycling ; GO:0032456 | - | Y | ||||||||||||||
77 | FBgg0000533 | CPX-2781 | GATOR1 COMPLEX | GAT1 | Iml1 complex|SEA subcomplex inhibiting TORC1|SEACIT/GATOR1 | SEACIT | GATOR1 is a subcomplex of the GATOR (SEA) complex. GATOR1 possesses Rag GTPase activating protein activity and inhibits TORC1 activity in response to amino acid starvation. (Adapted from FBrf0232362 and PMID:25934700). | Q9W0E3,Q9VXA0,Q9VUB4 | 27166823,21454883,27672113 | GATOR1 complex ; GO:1990130 | - | - | Y | ||||||||||||||
78 | FBgg0000534 | CPX-2664 | GATOR2 COMPLEX | GAT2 | SEA subcomplex activating TORC1|SEACAT/GATOR2 | SEACAT | GATOR2 is a subcomplex of the GATOR or SEA complex. It suppresses the Rag GTPase activating protein activity of the GATOR1 subcomplex, promoting TORC1 activity. (Adapted from FBrf0232362 and PMID:25934700). | Q9VQ89,Q7K2X8,Q9V3J4,Q9XZ25,Q9VKK2 | 27166823,21454883 | GATOR2 complex ; GO:0061700 | - | - | Y | ||||||||||||||
79 | FBgg0001613 | CPX-2670 | GINS COMPLEX | GINS | Go, Ichi, Ni and San complex | - | The heterotetrameric GINS complex is essential for the establishment of DNA replication forks and replisome progression in eukaryotes. GINS is one of the core components of the replicative helicase, the CMG (Cdc45-MCM-GINS) complex, activating the helicase activity of MCM to unwind duplex DNA ahead of the moving replication fork. Eukaryotic GINS also links with other key proteins at the fork to maintain an active replisome progression complex. (Adapted from PMID:22918584 and PMID:20070258.) | Q9W0I7,Q9VQY9,Q9W2V7,Q9VBI1 | 21378962,25117490,16798881 | GINS complex ; GO:0000811 | DNA strand elongation involved in mitotic DNA replication ; GO:1902983|pre-replicative complex assembly involved in nuclear cell cycle DNA replication ; GO:0006267 | - | Y | ||||||||||||||
80 | FBgg0000613 | CPX-2676 | GLYCOSYLPHOSPHATIDYLINOSITOL ETHANOLAMINE-PHOSPHATE TRANSFERASE II COMPLEX | GPI-ET-II | GLYCOSYLPHOSPHATIDYLINOSITOL ETHANOLAMINE-PHOSPHATE TRANSFERASE II|EtNP transferase II|GPI-ET II complex | - | In glycosylphosphatidylinositol (GPI)-anchor biosynthesis, the GPI-ethanolamine-phosphate transferase II complex catalyzes the conversion of ethanolamine-phosphate-mannose-mannose-(ethanolamine-phosphate)mannose-N-acetyl glucosamine-(acyl)phosphatidylinositol (EtNP-Man-Man-(EtNP)Man-GlcN-(acyl)PI) to EtNP-Man-(EtNP)Man-(EtNP)Man-GlcN-(acyl)PI. (Adapted from PMID:26563290). | Q9VW21,A1Z705 | 23250212 | - | GPI anchor biosynthetic process ; GO:0006506 | - | Y | ||||||||||||||
81 | FBgg0000620 | CPX-2695 | GLYCOSYLPHOSPHATIDYLINOSITOL ETHANOLAMINE-PHOSPHATE TRANSFERASE III COMPLEX | GPI-ET-III | GLYCOSYLPHOSPHATIDYLINOSITOL ETHANOLAMINE-PHOSPHATE TRANSFERASE III|EtNP transferase III|GPI-ET III complex|GPI-EtNP transferase 3 | - | In glycosylphosphatidylinositol (GPI)-anchor biosynthesis, the GPI-ethanolamine-phosphate transferase III complex catalyzes the addition of ethanolamine-phosphate (EtNP) to mannose-mannose-(EtNP)mannose-N-acetyl glucosamine-(acyl)phosphatidylinositol generating EtNP-Man-Man-(EtNP)Man-GlcN-(acyl)PI. (Adapted from PMID:26563290). | Q9VW21,A1ZB84 | 23250212 | - | GPI anchor biosynthetic process ; GO:0006506 | - | Y | ||||||||||||||
82 | FBgg0000629 | CPX-2685 | GLYCOSYLPHOSPHATIDYLINOSITOL-N-ACETYLGLUCOSAMINYLTRANSFERASE COMPLEX | GPI-GNT | GLYCOSYLPHOSPHATIDYLINOSITOL - N - ACETYLGLUCOSAMINYLTRANSFERASE|GLYCOSYLPHOSPHATIDYLINOSITOL-N-ACETYLGLUCOSAMINYLTRANSFERASE|GPI-GlcNAc transferase|GPI-GnT complex|GPI-N-acetylglucosaminyltransferase | - | In glycosylphosphatidylinositol (GPI)-anchor biosynthesis, the GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex catalyzes the transfer of N-acteylglucosamine (GlcNAc) to phosphatidylinositol (PI) generating GlcNAc-PI. The PIG-A gene encodes the catalytic subunit of the complex. (Adapted from PMID:11102867 and PMID:19883648). | Q7JUM3,A0A2U8U156,Q9VHX6,Q8MSE4,Q8IR17 | 23250212 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506 | GPI anchor biosynthetic process ; GO:0006506 | phosphatidylinositol N-acetylglucosaminyltransferase activity ; GO:0017176 | Y | ||||||||||||||
83 | FBgg0000622 | CPX-2686 | GLYCOSYLPHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE I COMPLEX | GPI-MT-I | GLYCOSYLPHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE I|a1-4mannosyltransferase I|GPI-MT-I complex | - | In glycosylphosphatidylinositol (GPI)-anchor biosynthesis, the GPI mannosyltransferase I complex transfers mannose to glucosamine-(acyl)phosphatidylinositol, generating mannose-N-acetyl glucosamine-(acyl)phosphatidylinositol. (Adapted from PMID:17519279). | Q9W2E4,A0A0B4LES9 | 23250212 | glycosylphosphatidylinositol-mannosyltransferase I complex ; GO:1990529 | GPI anchor biosynthetic process ; GO:0006506 | alpha-1,4-mannosyltransferase activity ; GO:0051751 | Y | ||||||||||||||
84 | FBgg0000616 | CPX-2687 | GLYCOSYLPHOSPHATIDYLINOSITOL TRANSAMIDASE COMPLEX | GPI-TA | GLYCOSYLPHOSPHATIDYLINOSITOL TRANSAMIDASE|GPI transamidase | - | In glycosylphosphatidylinositol (GPI)-anchor biosynthesis, the GPI transamidase complex mediates GPI anchoring in the endoplasmic reticulum by replacing the protein's C-terminal GPI-attachment signal peptide with a preassembled GPI. (Adapted from PMID:11483512 and PMID:19883648). | Q9W464,Q8T4E1,Q9VC10,Q9W3G0,Q9VLK0 | 33496978,23250212 | GPI-anchor transamidase complex ; GO:0042765 | attachment of GPI anchor to protein ; GO:0016255 | GPI-anchor transamidase activity ; GO:0003923 | Y | ||||||||||||||
85 | FBgg0001062 | CPX-2673 | GAMMA SECRETASE COMPLEX | GSC | Gamma secretase|Intramembrane aspartyl protease gamma-secretase|gamma-secretase | - | The gamma-secretase complex is an intramembrane aspartyl protease complex that cleaves transmembrane proteins. In particular, it is known for cleaving amyloid precursor protein (Appl) and Notch (N) receptor. It is essential for Notch signaling, performing the second ligand-simulated cleavage, which yields Notch intracellular domain. (Adapted from FBrf0211009). | Q9VQG2,Q9VC27,Q86BE9,O02194 | 20421416 | gamma-secretase complex ; GO:0070765 | Notch receptor processing ; GO:0007220|Notch signaling pathway ; GO:0007219 | aspartic-type endopeptidase activity ; GO:0004190 | Y | ||||||||||||||
86 | FBgg0001764 | CPX-2675 | H/ACA SMALL NUCLEOLAR RIBONUCLEOPROTEIN COMPLEX | Box H/ACA ribonucleoprotein complex | H-ACA | - | H/ACA RNPs | H/ACA small nucleolar ribonucleoprotein complex (H/ACA snoRNP) is a ribosome processing complex that catalyzes pseudouridylation of ribosomal RNA (rRNA) residues. The H/ACA sRNP complex is composed of four different core proteins that assemble onto a H/ACA guide RNA scaffold which identify target uridines in the rRNA for modification during ribosome synthesis. (Adapted from PMID:22065625, FBrf0239135 and FBrf0161482). | Q7KVQ0,Q9V5P6,Q9V3U2,O44081 | 26669894 | box H/ACA snoRNP complex ; GO:0031429 | snoRNA guided rRNA pseudouridine synthesis ; GO:0000454 | - | Y | |||||||||||||
87 | FBgg0000615 | HISTONE PRE-MRNA CLEAVAGE COMPLEX | pre-mRNA cleavage and polyadenylation specificity factor complex | HCC | HISTONE PRE - MRNA CLEAVAGE COMPLEX | - | Histone cleavage complex includes endonucleases and polyadenylation factors involved in processing of histone pre-mRNA. (Adapted from FBrf0223323 and PMID:23071092). | Q9VPT8,Q9VE51,Q9V3D6,Q9V726,Q9V9V0,Q9VE52,Q9VN31,P25991,Q8MSU4,Q9VNG2 | 26081560,24145821,28190776,19450530 | mRNA cleavage factor complex ; GO:0005849 | mRNA 3'-end processing by stem-loop binding and cleavage ; GO:0006398 | mRNA binding ; GO:0003729 | See notes: FBgg0000621, CPX-2768, CORE CLEAVAGE COMPLEX | ||||||||||||||
88 | FBgg0000902 | CPX-2691 | HYPOXIA-INDUCIBLE FACTOR | HIF | - | - | Hypoxia-inducible factor (HIF) mediates hypoxia-dependent transcription. It is a heterodimeric basic helix-loop-helix transcription factor complex composed of a constitutively expressed HIF-beta subunit and an oxygen-regulated HIF-alpha subunit. (Adapted from FBrf0190953). | Q24167,O15945 | 16278294 | RNA polymerase II transcription regulator complex ; GO:0090575 | positive regulation of transcription by RNA polymerase II ; GO:0045944 | DNA-binding transcription factor activity, RNA polymerase II-specific ; GO:0000981|transcription cis-regulatory region binding ; GO:0000976 | Y | ||||||||||||||
89 | FBgg0001342 | CPX-2700 | HEDGEHOG SIGNALING COMPLEX | HSC | - | - | The Hedgehog signaling complex (HSC) is involved in hedgehog signaling pathway. In the absence of hh, HSC promotes the proteolytic processing of the transcription factor and HSC component ci to its repressor form. hh activation of the pathway blocks the processing of ci, allowing the accumulation of the full-length activator protein. (Adapted from FBrf0174381.) | P19538,O16844,P23647 | 15104233,9244297,10825151 | Hedgehog signaling complex ; GO:0035301 | - | - | Y | ||||||||||||||
90 | FBgg0000075 | CPX-2702 | INTRAFLAGELLAR TRANSPORT SUBCOMPLEX-A | IFT-A | Intraciliary transport particle A|Intraflagellar transport complex A|Intraflagellar transport particle A | IFT A | Intraflagella Transport (IFT) complex proteins are evolutionary related to coat protein complexes. The IFT-A subcomplex mediates retrograde transport of large proteins/complexes within the intraflagella transport system. It interacts with the BBSome and IFT-B complexes. (Adapted from PMID:22118932, PMID:19575670 and FBrf0223369). | Q9VK67,Q9VSJ6,Q9W097,A1ZBM3,Q7KTZ4 | 15137945,16435301,23569277 | intraciliary transport particle A ; GO:0030991|non-motile cilium ; GO:0097730 | cilium assembly ; GO:0060271|intraciliary retrograde transport ; GO:0035721 | - | Y | ||||||||||||||
91 | FBgg0000140 | CPX-2704 | INTRAFLAGELLAR TRANSPORT SUBCOMPLEX-B | IFT-B | Intraciliary transport particle B|Intraflagellar transport complex B|intraflagellar transport particle B | IFT B | Intraflagella Transport (IFT) complex proteins are evolutionary related to coat protein complexes. The IFT-B subcomplex mediates anterograde transport of large proteins/complexes within the intraflagella transport system. It interacts with the BBSome and IFT-A complexes. (Adapted from PMID:22118932, PMID:19575670 and FBrf0223369). | Q9VR64,A1Z6F0,Q9VJ72,Q9VMC0,Q9VFL0,Q9VQS5,Q7KRS6,Q9W040,Q9VII8,Q9VF41,Q9VK41 | 15137945,16435301,23569277 | cilium ; GO:0005929|intraciliary transport particle B ; GO:0030992 | cilium assembly ; GO:0060271 | - | Y | ||||||||||||||
92 | FBgg0000291 | CPX-2693 | INO80 COMPLEX | INO80 chromatin remodeling complex | INO80 | INO80 remodelling complex|Inositol requiring 80 complex | Pho-dINO80|PHO-INO80 | The INO80 complex is an ATP-dependent chromatin remodeller that can mobilize nucleosomes. (Adapted from PMID:17316710). | P10987,Q9VEC3,Q9VX09,Q9VDY1,Q8ST83,Q9VH07,Q9V3K3, Q9VZJ3 | 19355820,16618800 | Ino80 complex ; GO:0031011 | chromatin remodeling ; GO:0006338 | ATP hydrolysis activity ; GO:0016887|DNA helicase activity ; GO:0003678 | Not sure if we should add Rcd5. No exp evidence, and no paper directly linked to this in FB. | |||||||||||||
93 | FBgg0000914 | CPX-2706 | KIBRA-EX-MER COMPLEX | KEM | KEM complex | - | The KEM complex is an apical protein complex that contains the proteins Kibra, Expanded and Merlin. It positively regulates the Hippo pathway, acting as a scaffolding complex. (Adapted from FBrf0210017). | Q07436,Q9VFG8,Q24564 | 20159600 | Kibra-Ex-Mer complex ; GO:0036375 | positive regulation of hippo signaling ; GO:0035332 | - | Y | ||||||||||||||
94 | FBgg0001735 | CPX-2708 | KIP1 UBIQUITINATION-PROMOTING COMPLEX | KPC | - | - | KIP1 ubiquitination-promoting complex (KPC) is a heterodimeric E3 ubiquitin ligase complex. In Drosophila, it is male-specific (FBrf0247735). | Q9VFC4,A0A0B4KFW5 | 33378371 | ubiquitin ligase complex ; GO:0000151 | protein ubiquitination ; GO:0016567 | ubiquitin protein ligase activity ; GO:0061630 | Y | ||||||||||||||
95 | FBgg0001685 | CPX-2709 | RAGULATOR COMPLEX | LAMTOR | - | - | The Ragulator complex is a lysosome associated pentameric complex which acts as a guanyl-nucleotide exchange factor for the Rag GTPases (Rags). It tethers the Rags to the lysosome membrane and interacts with the v-ATPase. In response to amino acid availability, this system jointly acts to regulate the translocation to the lysosomal surface, and thereby the activation, of TORC1. (Adapted from FBrf0225443 and FBrf0214985.) | Q9VW73,Q9V8I2Q9VJD2,,Q9VZL6,O96824 | 22980980,20381137 | Ragulator complex ; GO:0071986 | positive regulation of TORC1 signaling ; GO:1904263 | guanyl-nucleotide exchange factor activity ; GO:0005085 | Y | ||||||||||||||
96 | FBgg0001724 | CPX-2710 | LITTLE ELONGATION COMPLEX | LEC | - | - | The little elongation complex (LEC) is a distinct eleven_nineteen lysine_rich leukemia family RNAPII elongation factors (ELL)-containing complex that shares some structural and functional properties with super elongation complexes (SECs). This complex is required for the expression of RNA polymerase II-transcribed small nuclear RNA (snRNA) genes. (Adapted from FBrf0222548, FBrf0217100 and PMID:22895430). | Q7JRJ1,Q9W1R4,Q8SZZ8,Q9VW51 | 23932780,22195968 | - | positive regulation of snRNA transcription by RNA polymerase II ; GO:1905382 | - | Y | ||||||||||||||
97 | FBgg0000153 | CPX-2331 | MON1-CCZ1 COMPLEX | MCC | - | - | As endosomes mature, Rab5 is replaced with Rab7 in a process known as Rab conversion. The Mon1-Ccz1 complex is required for this process. It is recruited to endosomes by the CORVET complex and acts as a guanine nucleotide exchange factor (GEF) for Rab7. (Adapted from PMID:21683469). | Q9VRX1,Q9VZL5,Q9VR38 | 32499409,23418349 | Mon1-Ccz1 complex ; GO:0035658 | endosome to lysosome transport via multivesicular body sorting pathway ; GO:0032510 | guanyl-nucleotide exchange factor activity ; GO:0005085 | Y | ||||||||||||||
98 | FBgg0001614 | CPX-2942 | MCM2-7 COMPLEX | MCM2-7 | MCM complex|mini-chromosome maintenance complex | - | The heterohexameric MCM2-7 complex is the helicase motor of the CMG (Cdc45-MCM-GINS) replicative helicase of eukaryotes. The six MCM subunits are related to one another and are members of the AAA+ (ATPases associated with diverse cellular activities) superfamily. Hydrolysis of ATP by the individual MCM subunits catalyses the conformational changes that drive unwinding of the DNA duplex. However, the eukaryotic MCM complex alone has no or little helicase activity, requiring the other components of the CMG complex (Cdc45 and the GINS complex) for activation. (Adapted from PMID:23412083.) | Q26454,P49735,Q9XYU1,Q9VGW6,Q9V461,Q9XYU0 | 16189551,21378962,25117490,17786205,20122406,16798881 | MCM complex ; GO:0042555 | DNA unwinding involved in DNA replication ; GO:0006268 | 3'-5' DNA helicase activity ; GO:0043138 | Y | ||||||||||||||
99 | FBgg0000725 | CPX-2333 | MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX | MCUNI | Uniplex complex | MCU | The mitochondrial calcium uniporter complex is a Ca2[+]-activated channel that mediates the import of Ca2[+] ions from the cytosol into the mitochondrion. (Adapted from FBrf0233624). | Q7JX57,Q8IQ70,A2VEI2 | 27099988 | uniplex complex ; GO:1990246 | mitochondrial calcium ion transmembrane transport ; GO:0006851 | uniporter activity ; GO:0015292 | Y | ||||||||||||||
100 | FBgg0000359 | CPX-2308 | MEDIATOR COMPLEX | MED | Mediator | - | The Mediator (MED) complex serves as a hub for transcriptional signaling events. MED bridges transcriptional activators and repressors. This large multi-protein complex has a central core conserved from yeast to humans. The core is composed of three modules: head, middle, and tail. A separate module, the Cdk8 kinase module, composed of Cdk8, CycC, kto and skd, serves as a regulator. (Adapted from FBrf0226415 and FBrf0191850). | Q9VT57,P25008,Q7KBL8,Q9VW47,Q9VP05,Q9VS38,Q8MSX2,Q9GYV9,A1ZBT5,A1ZB42,Q9GYU7,Q9VVS4,Q9W0P8,Q9Y149,Q9W278,Q9VEC1,Q9XZT1,Q9VVL6,P91641,Q9W5P1,Q9V439,Q9W1X7,Q9VSF2,Q9VDR1,Q9V4F9,Q9VNG0,Q9VBQ9,Q9W0P3,Q8IH24,Q7KTX8 | 11090137,15175151,12021283,25126791,24820420,11511356,11259581 | mediator complex ; GO:0016592 | transcription by RNA polymerase II ; GO:0006366 | transcription coregulator activity ; GO:0003712 | Y | ||||||||||||||